MCID: NCR002
MIFTS: 38

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

MalaCards integrated aliases for Necrobiosis Lipoidica:

Name: Necrobiosis Lipoidica 12 20 58 44 15 17 70
Oppenheim-Urbach Disease 20 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:3486
MeSH 44 D009335
NCIt 50 C34840
SNOMED-CT 67 201319007
ICD10 32 L92.1
ICD10 via Orphanet 33 L92.1
Orphanet 58 ORPHA542592
UMLS 70 C0027538

Summaries for Necrobiosis Lipoidica

GARD : 20 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring.

MalaCards based summary : Necrobiosis Lipoidica, also known as oppenheim-urbach disease, is related to skin sarcoidosis and skin disease. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Tight junction and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, eye and thymus, and related phenotype is no phenotypic analysis.

Wikipedia : 73 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 skin sarcoidosis 30.9 TNF CD1B
2 skin disease 30.4 TNF INS CD1A CD163
3 cellulitis 30.1 TNF INS
4 tuberculoid leprosy 30.1 TNF CD1B
5 granulomatous dermatitis 29.7 TNF CD68 CD1E CD1B CD163
6 langerhans cell histiocytosis 29.7 CD68 CD1A CD163
7 histiocytosis 29.7 TNF CD1A CD163
8 granuloma annulare 29.7 TNF GLI1 CD68 CD1E CD1B CD1A
9 leprosy 3 28.7 TNF CD68 CD1E CD1B CD1A
10 sarcoidosis 1 10.8
11 type 1 diabetes mellitus 10.5
12 venous insufficiency 10.4
13 vasculitis 10.4
14 panniculitis 10.4
15 squamous cell carcinoma 10.4
16 chronic granulomatous disease 10.4
17 localized scleroderma 10.4
18 necrobiotic xanthogranuloma 10.4
19 exanthem 10.3
20 erythema elevatum diutinum 10.3
21 rheumatoid arthritis 10.3
22 dowling-degos disease 1 10.3
23 hashimoto thyroiditis 10.3
24 telangiectasis 10.3
25 balanitis 10.3
26 skin atrophy 10.3
27 systemic scleroderma 10.3
28 pustulosis of palm and sole 10.3
29 thyroiditis 10.3
30 psoriasis 10.3
31 histiocytic sarcoma 10.2 CD68 CD163
32 glucose intolerance 10.2
33 pulmonary sarcoidosis 10.2
34 hypothyroidism 10.2
35 lipid metabolism disorder 10.2
36 syphilis 10.2
37 pyoderma 10.2
38 angiokeratoma 10.2
39 arthritis 10.2
40 diabetes mellitus 10.2
41 esophageal tuberculosis 10.2 CD68 CD163
42 nodular tenosynovitis 10.2 CD68 CD163
43 ischemic fasciitis 10.2 CD68 CD163
44 tenosynovial giant cell tumor 10.2 CD68 CD163
45 spondylarthropathy 10.2 TNF CD163
46 lymphoproliferative syndrome 1 10.2 CD68 CD163
47 retroperitoneal hemangiopericytoma 10.2 INS CD68
48 macrophage activation syndrome 10.1 TNF CD163
49 type 1 diabetes mellitus 23 10.1 TNF INS
50 renal glucosuria 10.1 SLC2A1 INS

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 CD68 GLI1 INS SLC2A1 TNF

Drugs & Therapeutics for Necrobiosis Lipoidica

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica Completed NCT03698864 Phase 2 PCS499
2 Ruxolitinib Cream in the Treatment of Cutaneous Necrobiosis Lipoidica Recruiting NCT04492618 Phase 2 Ruxolitinib
3 An Open-label Proof of Concept Study Regarding the Use of Secukinumab (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD) Recruiting NCT03791060 Phase 2 Secukinumab
4 A Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of PCS499 in Treating Ulcerations in Patients Who Have Necrobiosis Lipoidica Not yet recruiting NCT04800562 Phase 2 PCS499

Search NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

40
Skin, Eye, Thymus, Pancreas, Endothelial, Tongue, Neutrophil

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 776)
# Title Authors PMID Year
1
Laser and light therapies for the treatment of necrobiosis lipoidica. 61
32970197 2021
2
Comorbidities and diabetic complications in patients with necrobiosis lipoidica. 61
33722550 2021
3
Necrobiosis lipoidica: A case report with dermoscopic review. 61
33768804 2021
4
Atypical Ulcerative Necrobiosis Lipoidica Diabeticorum: A Case Study. 61
33745343 2021
5
Features of necrobiosis lipoidica in reflectance confocal microscopy. 61
33729541 2021
6
Sarcoidosis with necrobiosis-lipoidica-like skin lesions: A challenge for the dermatologist. 61
33364439 2021
7
Abatacept-Induced Panniculitis With Necrobiosis Lipoidica-Like Features in a Patient With Rheumatoid Arthritis. 61
33777549 2021
8
Layer Cake Granulomas: A Case of Calciphylaxis Coexisting With Necrobiosis Lipoidica. 61
33622630 2021
9
Use of fractionated microneedle radiofrequency for necrobiosis lipoidica. 61
33389307 2021
10
High Glucose Causes Distinct Expression Patterns of Primary Human Skin Cells by RNA Sequencing. 61
33763026 2021
11
Necrobiosis lipoidica-like lesions in a nondiabetic patient with systemic sarcoidosis: A case report and review of the literature. 61
33363822 2020
12
Ulcerative necrobiosis lipoidica with granulomatous vasculitis mimicking sclerosing panniculitis in a patient with sarcoidosis. 61
32614071 2020
13
Diabetes-associated dermatological manifestations in primary care and their association with vascular complications. 61
33520817 2020
14
Images of the month: A painful nodule arising within chronic necrobiosis lipoidica. 61
33199336 2020
15
Treatment of Necrobiosis Lipoidica With Pulsed Dye Laser. 61
31449080 2020
16
Squamous cell carcinoma superimposed on necrobiosis lipoidica: a rare complication. 61
32893038 2020
17
Conventional Photodynamic Therapy for Necrobiosis Lipoidica: Successful Treatment in a Series of 4 Cases. 61
32574711 2020
18
[Necrobiosis lipoidica: A complication of diabetes mellitus]. 61
32444254 2020
19
Necrobiosis lipoidica with rapid response to doxycycline. 61
32681529 2020
20
Necrobiosis Lipoidica Affecting the Leg: What Is the Best Treatment in a Patient with Very High Aesthetic Demand? 61
32802684 2020
21
Successful treatment of ulcerative necrobiosis lipoidica with janus kinase inhibitor. 61
32058637 2020
22
Pancreas-kidney transplantation resolves chronic necrobiosis lipoidica: A case report. 61
32358835 2020
23
A case of disseminated perforating necrobiosis lipoidica. 61
32477522 2020
24
Berardinelli-Seip Syndrome and Essential Thrombocytosis: An Unusual Association. 61
32647589 2020
25
Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature. 61
32605400 2020
26
Sarcoidosis With Cutaneous Manifestations of Necrobiosis Lipoidica. 61
31313692 2020
27
Granulomatous Phlebitis in Necrobiosis Lipoidica. 61
31124881 2020
28
Necrobiosis Lipoidica. 61
31520619 2020
29
The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature. 61
32226347 2020
30
Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid. 61
32021895 2020
31
Remission of necrobiosis lipoidica diabeticorum with a JAK1/2 inhibitor: A case report. 61
31981714 2020
32
Unilateral necrobiosis lipoidica of the flexor aspect of the lower leg. 61
31932340 2020
33
Clinical Significance of Diabetic Dermatopathy. 61
33324080 2020
34
Truncal necrobiosis lipoidica diabeticorum: A first case report. 61
33197774 2020
35
Necrobiosis Lipoidica Mimicking Cutaneous Sarcoidosis Finally Treated With an Intralesional Injection of Corticosteroid: A Case Report 61
32023016 2020
36
An Exuberant Case of Necrobiotic Xanthogranuloma. 61
32055516 2020
37
[Progressive necrosis of lipid: A case report]. 61
31848527 2019
38
The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science. 61
30659650 2019
39
Necrobiosis lipoidica in a Nigerian woman - Report of a case. 61
31719288 2019
40
Perforating necrobiosis lipoidica: good response to adalimumab. 61
31789246 2019
41
Necrobiosis lipoidica in a patient with monoclonal gammopathy of underdetermined significance. 61
31155702 2019
42
Ulcerative necrobiosis lipoidica diabeticorum successfully treated with topical sevoflurane and punch grafting. 61
31412426 2019
43
Necrobiosis lipoidica with bone involvement successfully treated with infliximab. 61
30877774 2019
44
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? 61
30506562 2019
45
Treatment-resistant ulcerative necrobiosis lipoidica in a diabetic patient responsive to ustekinumab. 61
31553866 2019
46
[Rare skin condition in a child with diabetes mellitus]. 61
31386312 2019
47
Penile necrobiosis lipoidica: case report and literature review. 61
30280413 2019
48
Papular spreading necrobiosis lipoidica: a rare clinical presentation of this pathology. 61
30739338 2019
49
Non-infectious granulomatous dermatoses. 61
31115996 2019
50
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. 61
30785603 2019

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.84 CD1E CD1B CD1A
2 11.56 TNF CD68 CD163
3
Show member pathways
11.47 TNF SLC2A1 INS
4 11.27 TNF CD1E CD1B CD1A
5 11.2 TNF CD1A CD163
6 10.92 TNF CD1E CD1B CD1A
7 10.61 TNF CD68
8 10.57 SLC2A1 INS

GO Terms for Necrobiosis Lipoidica

Cellular components related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 9.5 CD68 CD1B CD1A
2 endosome GO:0005768 9.46 CD68 CD1E CD1B CD1A
3 membrane raft GO:0045121 9.43 TNF SLC2A1 CD1A
4 integral component of plasma membrane GO:0005887 9.35 TNF SLC2A1 CD1E CD1A CD163
5 external side of plasma membrane GO:0009897 9.02 TNF CD1E CD1B CD1A CD163

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 TNF CD1E CD1B CD1A
2 acute-phase response GO:0006953 9.43 INS CD163
3 positive regulation of nitric-oxide synthase activity GO:0051000 9.4 TNF INS
4 negative regulation of lipid catabolic process GO:0050995 9.37 TNF INS
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 CD1E CD1B CD1A
6 regulation of protein secretion GO:0050708 9.26 TNF INS
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.13 CD1E CD1B CD1A
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.8 CD1E CD1B CD1A

Molecular functions related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.33 CD1E CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.13 CD1E CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.8 CD1E CD1B CD1A

Sources for Necrobiosis Lipoidica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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