MCID: NCR002
MIFTS: 39

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

MalaCards integrated aliases for Necrobiosis Lipoidica:

Name: Necrobiosis Lipoidica 12 54 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3486
MeSH 45 D009335
NCIt 51 C34840
SNOMED-CT 69 9418005
ICD10 34 L92.1
UMLS 74 C0027538

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 54 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring.

MalaCards based summary : Necrobiosis Lipoidica is related to granuloma annulare and diabetes mellitus. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Insulin resistance and HIF-1 signaling pathway. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and neutrophil, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 77 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

GenomeRNAi Phenotypes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.53 CD163 SCARB2
2 Decreased viability GR00381-A-2 9.53 CD163 SCARB2
3 Decreased viability GR00381-A-3 9.53 CD163 SCARB2
4 Decreased viability GR00402-S-2 9.53 CD163 SCARB2

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 GLI1 INS SCARB2 SLC2A1 TNFRSF1B
2 cellular MP:0005384 9.55 CD163 GLI1 INS SLC2A1 TNFRSF1B
3 nervous system MP:0003631 9.35 GLI1 INS SCARB2 SLC2A1 TNFRSF1B
4 renal/urinary system MP:0005367 8.92 GLI1 INS SCARB2 TNFRSF1B

Drugs & Therapeutics for Necrobiosis Lipoidica

Drugs for Necrobiosis Lipoidica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3 insulin Phase 4
4 Hypoglycemic Agents Phase 4
5 Insulin, Globin Zinc Phase 4
6 Antibodies, Monoclonal Phase 2
7 Immunologic Factors Phase 2
8 Immunoglobulins Phase 2
9 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 Secukinumab for NLD (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD) Recruiting NCT03791060 Phase 2 Secukinumab
3 A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica Recruiting NCT03698864 Phase 2 PCS499

Search NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

42
Skin, Thyroid, Neutrophil, Pancreas, Kidney, Tongue, Endothelial

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 431)
# Title Authors Year
1
The long-term effect of pulsed dye laser on Necrobiosis Lipoidica: A case study. ( 29461125 )
2019
2
Unconventional use of fractional ablative CO2 laser in necrobiosis lipoidica. ( 29737892 )
2019
3
Penile necrobiosis lipoidica: case report and literature review. ( 30280413 )
2019
4
Atypical presentation of necrobiosis lipoidica in a pediatric patient. ( 30506892 )
2019
5
Papular spreading necrobiosis lipoidica: a rare clinical presentation of this pathology. ( 30739338 )
2019
6
Necrobiosis lipoidica with superimposed pyoderma vegetans. ( 30758332 )
2019
7
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. ( 30785603 )
2019
8
Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient. ( 30870808 )
2019
9
Necrobiosis lipoidica with bone involvement successfully treated with infliximab. ( 30877774 )
2019
10
Concomitant necrobiosis lipoidica and splenic abscess. ( 30949338 )
2019
11
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? ( 30506562 )
2018
12
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. ( 29411412 )
2018
13
Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study. ( 29733914 )
2018
14
Ulcerated necrobiosis lipoidica: A cutaneous granulomatous reaction associated with systemic B-cell lymphoma. ( 29770790 )
2018
15
Improvement in Ulcerative Necrobiosis Lipoidica After Janus Kinase-Inhibitor Therapy for Polycythemia Vera. ( 29800055 )
2018
16
Necrobiosis lipoidica: a rare complication of diabetes. ( 30100968 )
2018
17
Ulcerated Necrobiosis Lipoidica. ( 30189174 )
2018
18
Necrobiosis lipoidica associated with sarcoidosis. ( 30216487 )
2018
19
An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis. ( 30246132 )
2018
20
Necrobiosis lipoidica. ( 30677798 )
2018
21
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism. ( 29469709 )
2017
22
Pentoxifylline: An effective therapy for necrobiosis lipoidica. ( 26559761 )
2017
23
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. ( 27101431 )
2017
24
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? ( 28071608 )
2017
25
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
26
Update: Therapie der Necrobiosis lipoidica. ( 28214306 )
2017
27
Update: Treatment of necrobiosis lipoidica. ( 28214312 )
2017
28
Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-α and hydroxychloroquine treatment for rheumatoid arthritis. ( 28331899 )
2017
29
Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp. ( 28560219 )
2017
30
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. ( 28650076 )
2017
31
Necrobiosis lipoidica following Q-switched laser tattoo removal. ( 28660728 )
2017
32
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
33
A case of annular elastolytic giant cell granuloma on unusual sites requiring the differential diagnosis of necrobiosis lipoidica. ( 28698165 )
2017
34
Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. ( 28914682 )
2017
35
Granulomatous skin disease with a histological pattern of palisading granuloma - an atypical facial necrobiosis lipoidica or more? ( 29422829 )
2017
36
Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. ( 25353715 )
2016
37
Pediatric-onset necrobiosis lipoidica. ( 26865027 )
2016
38
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. ( 26889139 )
2016
39
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. ( 26951036 )
2016
40
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. ( 26972191 )
2016
41
Anti-TNFα treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. ( 26975548 )
2016
42
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. ( 27001349 )
2016
43
Necrobiosis Lipoidica. ( 27686584 )
2016
44
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit Literaturüberblick. ( 27767276 )
2016
45
Necrobiosis lipoidica of the glans penis: a case report and literature review. ( 27767287 )
2016
46
Necrobiosis Lipoidica. ( 27771664 )
2016
47
Adipophilin expression in necrobiosis lipoidica, granuloma annulare, and sarcoidosis. ( 25357017 )
2015
48
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
49
Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. ( 25266162 )
2015
50
Necrobiosis lipoidica: a descriptive study of 35 cases. ( 25728565 )
2015

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 INS SLC2A1
2 11.26 INS SLC2A1
3 10.99 SLC2A1 TNFRSF1B
4
Show member pathways
10.65 SLC2A1 TNFRSF1B
5 9.83 INS SLC2A1

GO Terms for Necrobiosis Lipoidica

Cellular components related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 INS SCARB2 SLC2A1

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 CD163 INS

Molecular functions related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scavenger receptor activity GO:0005044 8.62 CD163 SCARB2

Sources for Necrobiosis Lipoidica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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