MCID: NCR002
MIFTS: 34

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

MalaCards integrated aliases for Necrobiosis Lipoidica:

Name: Necrobiosis Lipoidica 12 53 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3486
MeSH 44 D009335
NCIt 50 C34840
SNOMED-CT 68 9418005
ICD10 33 L92.1
UMLS 73 C0027538

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 53 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring.

MalaCards based summary : Necrobiosis Lipoidica is related to granuloma annulare and diabetes mellitus. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Insulin resistance and HIF-1 signaling pathway. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and thyroid, and related phenotypes are cellular and vision/eye

Wikipedia : 76 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 CD163 GLI1 INS SLC2A1 TNFRSF1B
2 vision/eye MP:0005391 8.92 CD163 INS RDH11 TNFRSF1B

Drugs & Therapeutics for Necrobiosis Lipoidica

Drugs for Necrobiosis Lipoidica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6
3 Hypoglycemic Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin
2 A Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica Recruiting NCT03698864 Phase 2 PCS499
3 Secukinumab for NLD (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD) Not yet recruiting NCT03791060 Phase 2 Secukinumab

Search NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

41
Skin, Pancreas, Thyroid, Kidney, Endothelial, Neutrophil, B Cells

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 426)
# Title Authors Year
1
Ulcerated necrobiosis lipoidica: A cutaneous granulomatous reaction associated with systemic B-cell lymphoma. ( 29770790 )
2018
2
The long-term effect of pulsed dye laser on Necrobiosis Lipoidica: A case study. ( 29461125 )
2018
3
Unconventional use of fractional ablative CO<sub>2</sub> laser in necrobiosis lipoidica. ( 29737892 )
2018
4
Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study. ( 29733914 )
2018
5
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. ( 29411412 )
2018
6
Improvement in Ulcerative Necrobiosis Lipoidica After Janus Kinase-Inhibitor Therapy for Polycythemia Vera. ( 29800055 )
2018
7
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? ( 30506562 )
2018
8
Necrobiosis lipoidica: a rare complication of diabetes. ( 30100968 )
2018
9
Ulcerated Necrobiosis Lipoidica. ( 30189174 )
2018
10
Necrobiosis lipoidica associated with sarcoidosis. ( 30216487 )
2018
11
An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis. ( 30246132 )
2018
12
Penile necrobiosis lipoidica: case report and literature review. ( 30280413 )
2018
13
Atypical presentation of necrobiosis lipoidica in a pediatric patient. ( 30506892 )
2018
14
Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-I+ and hydroxychloroquine treatment for rheumatoid arthritis. ( 28331899 )
2017
15
Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp. ( 28560219 )
2017
16
Update: Treatment of necrobiosis lipoidica. ( 28214312 )
2017
17
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. ( 28650076 )
2017
18
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? ( 28071608 )
2017
19
Necrobiosis Lipoidica ( 29083569 )
2017
20
Update: Therapie der Necrobiosis lipoidica. ( 28214306 )
2017
21
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
22
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism. ( 29469709 )
2017
23
Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. ( 28914682 )
2017
24
Necrobiosis lipoidica following Q-switched laser tattoo removal. ( 28660728 )
2017
25
Granulomatous skin disease with a histological pattern of palisading granuloma - an atypical facial necrobiosis lipoidica or more? ( 29422829 )
2017
26
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
27
A case of annular elastolytic giant cell granuloma on unusual sites requiring the differential diagnosis of necrobiosis lipoidica. ( 28698165 )
2017
28
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. ( 26951036 )
2016
29
Necrobiosis Lipoidica. ( 27686584 )
2016
30
Necrobiosis lipoidica of the glans penis: a case report and literature review. ( 27767287 )
2016
31
Necrobiosis Lipoidica. ( 27771664 )
2016
32
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. ( 26975548 )
2016
33
Pediatric-onset necrobiosis lipoidica. ( 26865027 )
2016
34
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit LiteraturA1berblick. ( 27767276 )
2016
35
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. ( 26889139 )
2016
36
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. ( 27101431 )
2016
37
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. ( 26972191 )
2016
38
Kofaktoren und KomorbiditAoten bei Necrobiosis lipoidica - Analyse der deutschen DRG-Daten von 2012. ( 26972192 )
2016
39
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. ( 27001349 )
2016
40
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
41
Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. ( 26236446 )
2015
42
Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies. ( 26273437 )
2015
43
Necrobiosis Lipoidica. ( 26143418 )
2015
44
Necrobiosis Lipoidica: A Descriptive Study of 35 Cases. ( 25728565 )
2015
45
Necrobiosis lipoidica diabeticorum. ( 26057508 )
2015
46
Pentoxifylline: An effective therapy for necrobiosis lipoidica. ( 26559761 )
2015
47
Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. ( 26575980 )
2015
48
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. ( 25611281 )
2014
49
Necrobiosis lipoidica with elastophagocytosis on an unusual location. ( 24786578 )
2014
50
Adipophilin Expression in Necrobiosis Lipoidica, Granuloma Annulare, and Sarcoidosis. ( 25357017 )
2014

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 INS SLC2A1
2 11.26 INS SLC2A1
3 10.99 SLC2A1 TNFRSF1B
4
Show member pathways
10.65 SLC2A1 TNFRSF1B
5 9.83 INS SLC2A1

GO Terms for Necrobiosis Lipoidica

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 CD163 INS

Sources for Necrobiosis Lipoidica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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