MCID: NCR002
MIFTS: 38

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 53 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring.

MalaCards based summary : Necrobiosis Lipoidica is related to granuloma annulare and diabetes mellitus. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Insulin resistance and HIF-1 signaling pathway. The drugs Insulin glulisine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and thyroid, and related phenotypes are cellular and vision/eye

Wikipedia : 76 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 granuloma annulare 30.5 GLI1 TNFRSF1B
2 diabetes mellitus 10.6
3 squamous cell carcinoma 10.4
4 venous insufficiency 10.3
5 rheumatoid arthritis 10.2
6 arthritis 10.2
7 skin sarcoidosis 10.2
8 thyroiditis 10.2
9 balanitis 10.1
10 dermatitis 10.1
11 angiokeratoma 10.1
12 psoriasis 10.1
13 type i 10.1
14 endotheliitis 10.1
15 neutrophil migration 10.0
16 ataxia-telangiectasia 10.0
17 polycythemia vera 10.0
18 maturity-onset diabetes of the young 10.0
19 b-cell lymphomas 10.0
20 common variable immunodeficiency 10.0
21 cutaneous leishmaniasis 10.0
22 lymphomatoid granulomatosis 10.0
23 skin disease 10.0
24 lymphoma 10.0
25 hypothyroidism 10.0
26 histiocytosis 10.0
27 cellulitis 10.0
28 retinitis 10.0
29 syphilis 10.0
30 pyoderma 10.0
31 granulomatous dermatitis 10.0
32 retinal disease 10.0
33 tertiary syphilis 10.0
34 polycythemia 10.0
35 lupus erythematosus 10.0
36 leishmaniasis 10.0
37 necrobiotic xanthogranuloma 10.0
38 discoid lupus erythematosus 10.0
39 central nervous system tuberculosis 9.8 CD163 GLI1
40 chronic salpingitis 9.3 SLC2A1 TNFRSF1B
41 hyperglycemia 9.2 INS SLC2A1

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 CD163 GLI1 INS SLC2A1 TNFRSF1B
2 vision/eye MP:0005391 8.92 RDH11 TNFRSF1B CD163 INS

Drugs & Therapeutics for Necrobiosis Lipoidica

Drugs for Necrobiosis Lipoidica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin glulisine Approved Phase 4 207748-29-6
2
Zinc Approved, Investigational Phase 4 7440-66-6 23994
3 Hypoglycemic Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Beneficial Effect of Insulin Glulisine by Lipoatrophy and Type 1 Diabetes (LAS) Enrolling by invitation NCT02914886 Phase 4 Apidra;current insulin

Search NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

41
Skin, Pancreas, Thyroid, Neutrophil, Kidney, Endothelial, Eye

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 410)
# Title Authors Year
1
Ulcerated necrobiosis lipoidica: A cutaneous granulomatous reaction associated with systemic B-cell lymphoma. ( 29770790 )
2018
2
The long-term effect of pulsed dye laser on Necrobiosis Lipoidica: A case study. ( 29461125 )
2018
3
Unconventional use of fractional ablative CO<sub>2</sub> laser in necrobiosis lipoidica. ( 29737892 )
2018
4
Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study. ( 29733914 )
2018
5
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. ( 29411412 )
2018
6
Improvement in Ulcerative Necrobiosis Lipoidica After Janus Kinase-Inhibitor Therapy for Polycythemia Vera. ( 29800055 )
2018
7
Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-I+ and hydroxychloroquine treatment for rheumatoid arthritis. ( 28331899 )
2017
8
Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp. ( 28560219 )
2017
9
Update: Treatment of necrobiosis lipoidica. ( 28214312 )
2017
10
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. ( 28650076 )
2017
11
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? ( 28071608 )
2017
12
Necrobiosis Lipoidica ( 29083569 )
2017
13
Update: Therapie der Necrobiosis lipoidica. ( 28214306 )
2017
14
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
15
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism. ( 29469709 )
2017
16
Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. ( 28914682 )
2017
17
Necrobiosis lipoidica following Q-switched laser tattoo removal. ( 28660728 )
2017
18
Granulomatous skin disease with a histological pattern of palisading granuloma - an atypical facial necrobiosis lipoidica or more? ( 29422829 )
2017
19
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
20
A case of annular elastolytic giant cell granuloma on unusual sites requiring the differential diagnosis of necrobiosis lipoidica. ( 28698165 )
2017
21
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. ( 26951036 )
2016
22
Necrobiosis Lipoidica. ( 27686584 )
2016
23
Necrobiosis lipoidica of the glans penis: a case report and literature review. ( 27767287 )
2016
24
Necrobiosis Lipoidica. ( 27771664 )
2016
25
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. ( 26975548 )
2016
26
Pediatric-onset necrobiosis lipoidica. ( 26865027 )
2016
27
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit LiteraturA1berblick. ( 27767276 )
2016
28
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. ( 26889139 )
2016
29
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. ( 27101431 )
2016
30
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. ( 26972191 )
2016
31
Kofaktoren und KomorbiditAoten bei Necrobiosis lipoidica - Analyse der deutschen DRG-Daten von 2012. ( 26972192 )
2016
32
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. ( 27001349 )
2016
33
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
34
Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. ( 26236446 )
2015
35
Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies. ( 26273437 )
2015
36
Necrobiosis Lipoidica. ( 26143418 )
2015
37
Necrobiosis Lipoidica: A Descriptive Study of 35 Cases. ( 25728565 )
2015
38
Necrobiosis lipoidica diabeticorum. ( 26057508 )
2015
39
Pentoxifylline: An effective therapy for necrobiosis lipoidica. ( 26559761 )
2015
40
Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. ( 26575980 )
2015
41
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. ( 25611281 )
2014
42
Necrobiosis lipoidica with elastophagocytosis on an unusual location. ( 24786578 )
2014
43
Adipophilin Expression in Necrobiosis Lipoidica, Granuloma Annulare, and Sarcoidosis. ( 25357017 )
2014
44
Residents'corner February 2014. DeRmpath &amp;amp; Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. ( 24691245 )
2014
45
Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: Case report and literature review. ( 25150669 )
2014
46
Ulcerated necrobiosis lipoidica to a teenager with diabetes mellitus and obesity. ( 24715184 )
2014
47
Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. ( 25353715 )
2014
48
Necrobiosis lipoidica-like cutaneous leishmaniasis. ( 25368717 )
2014
49
Selective case study describing the use of Apligraf on necrobiosis lipoidica associated with diabetes. ( 24600755 )
2014
50
Palmoplantar pustulosis associated with necrobiosis lipoidica: a possible role of tumor necrosis factor-I+ and interleukin-17. ( 24628381 )
2014

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 INS SLC2A1
2 11.26 INS SLC2A1
3 10.99 SLC2A1 TNFRSF1B
4
Show member pathways
10.65 SLC2A1 TNFRSF1B
5 9.83 INS SLC2A1

GO Terms for Necrobiosis Lipoidica

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.26 INS TNFRSF1B
2 response to insulin GO:0032868 9.16 INS SLC2A1
3 positive regulation of DNA replication GO:0045740 8.96 GLI1 INS
4 acute-phase response GO:0006953 8.62 CD163 INS

Sources for Necrobiosis Lipoidica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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