MCID: NCR002
MIFTS: 38

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

MalaCards integrated aliases for Necrobiosis Lipoidica:

Name: Necrobiosis Lipoidica 12 52 58 43 15 17 71
Oppenheim-Urbach Disease 52 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:3486
MeSH 43 D009335
NCIt 49 C34840
SNOMED-CT 67 9418005
ICD10 32 L92.1
Orphanet 58 ORPHA542592
UMLS 71 C0027538

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 52 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes , in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring.

MalaCards based summary : Necrobiosis Lipoidica, also known as oppenheim-urbach disease, is related to pustulosis of palm and sole and skin disease. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Insulin resistance. Affiliated tissues include skin, pancreas and breast, and related phenotype is no phenotypic analysis.

Wikipedia : 74 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.8 TNFRSF1B TNF
2 skin disease 30.7 TNFRSF1B TNF CD1A CD163
3 skin sarcoidosis 30.4 TNFRSF1B TNF CD1E
4 granulomatous dermatitis 30.4 TNFRSF1B TNF CD68 CD163
5 langerhans cell histiocytosis 30.1 CD68 CD1A CD163
6 histiocytosis 30.1 TNF CD1A CD163
7 autoimmune disease 29.7 TNFRSF1B TNF INS CD163
8 granuloma annulare 29.5 TNFRSF1B TNF GLI1 CD68 CD1E CD1A
9 leprosy 3 29.4 TNF CD1E CD1A
10 diabetes mellitus 10.9
11 sarcoidosis 1 10.9
12 squamous cell carcinoma 10.6
13 venous insufficiency 10.5
14 diabetes mellitus, type i 10.5
15 chronic granulomatous disease 10.5
16 localized scleroderma 10.5
17 vasculitis 10.5
18 necrobiotic xanthogranuloma 10.5
19 hashimoto thyroiditis 10.4
20 erythema elevatum diutinum 10.4
21 telangiectasis 10.4
22 balanitis 10.4
23 skin atrophy 10.4
24 systemic scleroderma 10.4
25 thyroiditis 10.4
26 psoriasis 10.4
27 diabetes mellitus, noninsulin-dependent 10.3
28 dowling-degos disease 1 10.3
29 exanthem 10.3
30 glucose intolerance 10.3
31 allergic hypersensitivity disease 10.3
32 pulmonary sarcoidosis 10.3
33 panniculitis 10.3
34 vascular disease 10.3
35 dermatitis 10.3
36 lipid metabolism disorder 10.3
37 syphilis 10.3
38 pyoderma 10.3
39 angiokeratoma 10.3
40 histiocytic sarcoma 10.3 CD68 CD163
41 tenosynovial giant cell tumor 10.2 CD68 CD163
42 spondylarthropathy 10.2 TNF CD163
43 retroperitoneal hemangiopericytoma 10.2 INS CD68
44 juvenile ankylosing spondylitis 10.2 TNFRSF1B TNF
45 rheumatoid arthritis interstitial lung disease 10.2 TNFRSF1B TNF
46 chromophil adenoma of the kidney 10.2 TNFRSF1B TNF
47 opportunistic bacterial infectious disease 10.2 TNFRSF1B TNF
48 neurofibromatosis, type ii 10.2
49 hypercholesterolemia, familial, 1 10.2
50 hypertension, essential 10.2

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 CD68 GLI1 INS SLC2A1 TNF

Drugs & Therapeutics for Necrobiosis Lipoidica

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label Study to Evaluate the Safety and Tolerability of PCS499 for the Treatment of Necrobiosis Lipoidica Completed NCT03698864 Phase 2 PCS499
2 An Open-label Proof of Concept Study Regarding the Use of Secukinumab (Cosentyx) in Patients With Necrobiosis Lipoidica Diabeticorum (NLD) Suspended NCT03791060 Phase 2 Secukinumab

Search NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

40
Skin, Pancreas, Breast, Kidney, Thyroid, Neutrophil, Testes

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 743)
# Title Authors PMID Year
1
Conventional Photodynamic Therapy for Necrobiosis Lipoidica: Successful Treatment in a Series of 4 Cases. 61
32574711 2020
2
A case of disseminated perforating necrobiosis lipoidica. 61
32477522 2020
3
[Necrobiosis lipoidica: A complication of diabetes mellitus]. 61
32444254 2020
4
Pancreas-kidney transplantation resolves chronic necrobiosis lipoidica: A case report. 61
32358835 2020
5
Granulomatous Phlebitis in Necrobiosis Lipoidica. 61
31124881 2020
6
Sarcoidosis With Cutaneous Manifestations of Necrobiosis Lipoidica. 61
31313692 2020
7
The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature. 61
32226347 2020
8
Necrobiosis Lipoidica. 61
31520619 2020
9
Successful treatment of ulcerative necrobiosis lipoidica with janus kinase inhibitor. 61
32058637 2020
10
Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid. 61
32021895 2020
11
Unilateral necrobiosis lipoidica of the flexor aspect of the lower leg. 61
31932340 2020
12
Remission of necrobiosis lipoidica diabeticorum with a JAK1/2 inhibitor: A case report. 61
31981714 2020
13
Necrobiosis Lipoidica Mimicking Cutaneous Sarcoidosis Finally Treated With an Intralesional Injection of Corticosteroid: A Case Report 61
32023016 2020
14
An Exuberant Case of Necrobiotic Xanthogranuloma. 61
32055516 2020
15
[Progressive necrosis of lipid: A case report]. 61
31848527 2019
16
The 2017 Banting Memorial Lecture The diabetic lower limb - a forty year journey: from clinical observation to clinical science. 61
30659650 2019
17
Necrobiosis lipoidica in a patient with monoclonal gammopathy of underdetermined significance. 61
31155702 2019
18
Necrobiosis lipoidica in a Nigerian woman - Report of a case. 61
31719288 2019
19
Perforating necrobiosis lipoidica: good response to adalimumab. 61
31789246 2019
20
Ulcerative necrobiosis lipoidica diabeticorum successfully treated with topical sevoflurane and punch grafting. 61
31412426 2019
21
Necrobiosis lipoidica with bone involvement successfully treated with infliximab. 61
30877774 2019
22
Treatment of Necrobiosis Lipoidica With Pulsed Dye Laser. 61
31449080 2019
23
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? 61
30506562 2019
24
Treatment-resistant ulcerative necrobiosis lipoidica in a diabetic patient responsive to ustekinumab. 61
31553866 2019
25
[Rare skin condition in a child with diabetes mellitus]. 61
31386312 2019
26
Papular spreading necrobiosis lipoidica: a rare clinical presentation of this pathology. 61
30739338 2019
27
Penile necrobiosis lipoidica: case report and literature review. 61
30280413 2019
28
Non-infectious granulomatous dermatoses. 61
31115996 2019
29
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes. 61
30785603 2019
30
Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient. 61
30870808 2019
31
Concomitant necrobiosis lipoidica and splenic abscess. 61
30949338 2019
32
The role of anti-tumour necrosis factor in wound healing: A case report of refractory ulcerated necrobiosis lipoidica treated with adalimumab and review of the literature. 61
31666953 2019
33
Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study. 61
30463069 2019
34
Advances in Inflammatory Granulomatous Skin Diseases. 61
30466688 2019
35
Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises. 61
31096219 2019
36
Atypical presentation of necrobiosis lipoidica in a pediatric patient. 61
30506892 2019
37
Unconventional use of fractional ablative CO2 laser in necrobiosis lipoidica. 61
29737892 2019
38
The long-term effect of pulsed dye laser on Necrobiosis Lipoidica: A case study. 61
29461125 2019
39
Necrobiosis lipoidica with superimposed pyoderma vegetans. 61
30758332 2019
40
Necrobiosis lipoidica associated with sarcoidosis. 61
30216487 2018
41
Necrobiosis lipoidica. 61
30677798 2018
42
Dermatoscopy of Granulomatous Disorders. 61
30201146 2018
43
Keratoacanthomatous Changes: Unifying the Histologic Spectrum of Actinic Granuloma. 61
29697422 2018
44
An atypical case of papular necrobiosis lipoidica masquerading as sarcoidosis. 61
30246132 2018
45
Ulcerated Necrobiosis Lipoidica. 61
30189174 2018
46
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. 61
29411412 2018
47
Systemic therapies for leg ulcers. 61
29989361 2018
48
Ulcerated necrobiosis lipoidica: A cutaneous granulomatous reaction associated with systemic B-cell lymphoma. 61
29770790 2018
49
Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study. 61
29733914 2018
50
Improvement in Ulcerative Necrobiosis Lipoidica After Janus Kinase-Inhibitor Therapy for Polycythemia Vera. 61
29800055 2018

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

GO Terms for Necrobiosis Lipoidica

Cellular components related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 TNF SLC2A1 CD1E CD1A CD163
2 external side of plasma membrane GO:0009897 9.26 TNF CD1E CD1A CD163
3 membrane raft GO:0045121 8.92 TNFRSF1B TNF SLC2A1 CD1A

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 TNFRSF1B TNF CD1E CD1A
2 cellular response to lipopolysaccharide GO:0071222 9.61 TNFRSF1B TNF CD68
3 acute-phase response GO:0006953 9.49 INS CD163
4 positive regulation of cytokine secretion GO:0050715 9.48 TNF INS
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1A
6 positive regulation of nitric-oxide synthase activity GO:0051000 9.4 TNF INS
7 negative regulation of lipid catabolic process GO:0050995 9.32 TNF INS
8 regulation of protein secretion GO:0050708 9.26 TNF INS
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.16 TNFRSF1B TNF
10 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.96 CD1E CD1A
11 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.62 CD1E CD1A

Molecular functions related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.16 CD1E CD1A
2 exogenous lipid antigen binding GO:0030884 8.96 CD1E CD1A
3 endogenous lipid antigen binding GO:0030883 8.62 CD1E CD1A

Sources for Necrobiosis Lipoidica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....