MCID: NCR008
MIFTS: 26

Necrotic Uveal Melanoma

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Necrotic Uveal Melanoma

MalaCards integrated aliases for Necrotic Uveal Melanoma:

Name: Necrotic Uveal Melanoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7808
NCIt 50 C7990
UMLS 70 C0279695 C1334931

Summaries for Necrotic Uveal Melanoma

Disease Ontology : 12 An uveal melanoma characterized by the presence of tumor cell necrosis.

MalaCards based summary : Necrotic Uveal Melanoma is related to cellulitis and melanoma, uveal. An important gene associated with Necrotic Uveal Melanoma is IFNG (Interferon Gamma), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include bone, lung and skin.

Related Diseases for Necrotic Uveal Melanoma

Diseases related to Necrotic Uveal Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.2 CD8A CD4
2 melanoma, uveal 10.3
3 orbital cellulitis 10.2
4 melanoma 10.2
5 allergic contact dermatitis 10.1 IFNG CD4
6 contact dermatitis 10.1 IFNG CD4
7 bacterial infectious disease 10.1 IFNG CD4
8 panophthalmitis 10.1 IFNG CD4
9 ocular tuberculosis 10.1 IFNG CD4
10 pericardial tuberculosis 10.1 IFNG CD4
11 penicilliosis 10.1 IFNG CD4
12 suppurative lymphadenitis 10.1 IFNG CD4
13 lymphadenitis 10.1 IFNG CD4
14 opportunistic bacterial infectious disease 10.1 IFNG CD4
15 nocardiosis 10.1 IFNG CD4
16 gastrointestinal tuberculosis 10.1 IFNG CD4
17 intestinal tuberculosis 10.1 IFNG CD4
18 lymph node tuberculosis 10.1 IFNG CD4
19 stomatitis 10.1 IFNG CD4
20 lung abscess 10.1 IFNG CD4
21 abdominal tuberculosis 10.1 IFNG CD4
22 tungiasis 10.0 IFNG CD4
23 retinal detachment 10.0
24 posterior uveal melanoma 10.0
25 exophthalmos 10.0
26 sporotrichosis 10.0 IFNG CD4
27 choroiditis 10.0 IFNG CD4
28 mucormycosis 10.0 IFNG CD4
29 strongyloidiasis 10.0 IFNG CD4
30 tuberculoid leprosy 10.0 IFNG CD4
31 hepatic tuberculosis 10.0 IFNG CD4
32 multidrug-resistant tuberculosis 10.0 IFNG CD4
33 phagocyte bactericidal dysfunction 10.0 IFNG CD4
34 pleural tuberculosis 10.0 IFNG CD4
35 multicentric castleman disease 10.0 IFNG CD4
36 castleman disease 10.0 IFNG CD4
37 autoimmune gastritis 10.0 IFNG CD4
38 cryptococcal meningitis 10.0 IFNG CD4
39 hypersplenism 10.0 IFNG CD4
40 folliculitis 10.0 IFNG CD4
41 nasal cavity disease 10.0 IFNG CD4
42 hepatitis a 10.0 IFNG CD4
43 cork-handlers' disease 10.0 CD8A CD4
44 early yaws 10.0 CD8A CD4
45 ventilation pneumonitis 10.0 CD8A CD4
46 diffuse infiltrative lymphocytosis syndrome 10.0 CD8A CD4
47 latent syphilis 10.0 CD8A CD4
48 type 1 diabetes mellitus 23 10.0 CD8A CD4
49 autoimmune lymphoproliferative syndrome 10.0 CD8A CD4
50 autoimmune lymphoproliferative syndrome, type iia 10.0 CD8A CD4

Graphical network of the top 20 diseases related to Necrotic Uveal Melanoma:



Diseases related to Necrotic Uveal Melanoma

Symptoms & Phenotypes for Necrotic Uveal Melanoma

Drugs & Therapeutics for Necrotic Uveal Melanoma

Search Clinical Trials , NIH Clinical Center for Necrotic Uveal Melanoma

Genetic Tests for Necrotic Uveal Melanoma

Anatomical Context for Necrotic Uveal Melanoma

MalaCards organs/tissues related to Necrotic Uveal Melanoma:

40
Bone, Lung, Skin, Lymph Node, Thymus, Bone Marrow, Eye

Publications for Necrotic Uveal Melanoma

Articles related to Necrotic Uveal Melanoma:

# Title Authors PMID Year
1
Necrotic uveal melanoma presenting as orbital cellulitis with intraocular hemorrhage: A case report. 61
31650085 2019
2
DIAGNOSTIC CHALLENGES IN NECROTIC UVEAL MELANOMA. 61
31425450 2019
3
Uveal Melanoma Mimicking Advanced Coats' Disease in a Young Patient. 61
27239453 2016
4
Necrotic uveal melanoma with orbital inflammation. 61
16952114 2006
5
Early-onset scleral necrosis after iodine I 125 plaque radiotherapy for ciliochoroidal melanoma. 61
10037576 1999
6
Massive infarction of ocular tissues complicating a necrotic uveal melanoma. 61
9683967 1998
7
Lipid crystals in malignant melanoma of the choroid. 61
2343196 1990

Variations for Necrotic Uveal Melanoma

Expression for Necrotic Uveal Melanoma

Search GEO for disease gene expression data for Necrotic Uveal Melanoma.

Pathways for Necrotic Uveal Melanoma

Pathways related to Necrotic Uveal Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 IFNG CD8A CD4
2
Show member pathways
12.04 IFNG CD8A CD4
3 11.75 CD8A CD4
4 11.7 CD8A CD4
5
Show member pathways
11.59 CD8A CD4
6 11.54 CD8A CD4
7
Show member pathways
11.5 IFNG CD4
8 11.5 IFNG CD8A CD4
9
Show member pathways
11.4 IFNG CD4
10
Show member pathways
11.38 IFNG CD8A CD4
11 11.36 CD8A CD4
12
Show member pathways
11.28 IFNG CD8A
13 11.14 IFNG CD4
14 11.03 IFNG CD8A CD4
15 11.01 CD8A CD4
16 10.87 IFNG CD4
17 10.82 IFNG CD4
18 10.67 IFNG CD8A CD4

GO Terms for Necrotic Uveal Melanoma

Cellular components related to Necrotic Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor complex GO:0042101 8.62 CD8A CD4

Biological processes related to Necrotic Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 IFNG CD8A CD4
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.37 CD8A CD4
3 adaptive immune response GO:0002250 9.33 IFNG CD8A CD4
4 T cell activation GO:0042110 9.32 CD8A CD4
5 macrophage differentiation GO:0030225 8.96 IFNG CD4
6 cell surface receptor signaling pathway GO:0007166 8.8 IFNG CD8A CD4

Molecular functions related to Necrotic Uveal Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Necrotic Uveal Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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