MCID: NCR007
MIFTS: 51

Necrotizing Fasciitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrotizing Fasciitis

MalaCards integrated aliases for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 76 53 3 15 73
Fasciitis, Necrotizing 44

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD10 33 M72.6
ICD9CM 35 728.86
MeSH 44 D019115
NCIt 50 C84916
SNOMED-CT 68 52486002
UMLS 73 C0238124

Summaries for Necrotizing Fasciitis

NIH Rare Diseases : 53 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue.

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fasciitis and noma, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vancomycin and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotype is cardiovascular system.

CDC : 3 Bacteria called group A Streptococcus (group A strep) can cause many different infections. Some of these are common, relatively minor infections, like strep throat. Others are less common, but very serious and even deadly. People can easily spread group A strep to other people. Practicing good hygiene, like washing your hands often, is the best way to protect yourself from group A strep infections.

Wikipedia : 76 Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 283)
# Related Disease Score Top Affiliating Genes
1 fasciitis 31.7 CD46 CXCL8 IL18 IL6 RPS17
2 noma 30.4 CXCL8 IL18
3 osteomyelitis 30.3 CXCL8 IL1RN IL6
4 toxic shock syndrome 30.2 CXCL8 IL2 IL6 LTA MYOM2
5 systemic lupus erythematosus 30.2 CXCL8 IL18 IL2 IL6 LTA
6 arthritis 30.1 CXCL8 IL18 IL1RN IL6 LTA
7 colitis 30.1 CXCL8 IL2 IL6
8 orbital cellulitis 30.0 IL1RN LTA
9 rheumatoid arthritis 30.0 CXCL8 IL18 IL1RN IL2 IL6
10 streptococcal toxic-shock syndrome 30.0 CXCL8 IL2 IL6 LTA MYOM2
11 crohn's colitis 30.0 CXCL8 IL2
12 tonsillitis 29.9 CXCL8 IL2 IL6 LTA
13 conjunctivitis 29.9 CXCL8 IL2 IL6
14 adult-onset still's disease 29.8 IL18 IL1RN IL6
15 ulcerative colitis 29.8 CXCL8 IL2 IL6
16 spondylitis 29.8 IL1RN IL6 LTA
17 diabetes mellitus 29.7 IL1RN IL2 IL6 LTA
18 aplastic anemia 29.5 IL2 IL6 LTA RPS17
19 psoriasis 29.5 CXCL8 IL18 IL2 IL6 LTA
20 myeloma, multiple 29.4 CXCL8 IL2 IL6 MYOM2
21 fournier gangrene 11.6
22 necrotizing soft tissue infection 10.4
23 gas gangrene 10.3
24 mediastinitis 10.3
25 diverticulitis 10.3
26 lupus erythematosus 10.3
27 cellulitis 10.3
28 pyoderma 10.3
29 pyoderma gangrenosum 10.3
30 myositis 10.3
31 sapho syndrome 10.2 CXCL8 IL18
32 peritonitis 10.2
33 haemophilus influenzae 10.2
34 recurrent corneal erosion 10.2 CXCL8 IL6
35 bagassosis 10.2 CXCL8 IL6
36 acute transverse myelitis 10.2 CXCL8 IL6
37 transverse myelitis 10.2 CXCL8 IL6
38 toxicodendron dermatitis 10.2 CXCL8 IL2
39 denture stomatitis 10.2 CXCL8 IL6
40 papillary conjunctivitis 10.2 CXCL8 IL6
41 funisitis 10.2 CXCL8 IL6
42 stachybotrys chartarum 10.2 IL18 IL6
43 acute monoblastic leukemia 10.2 CXCL8 IL6
44 trichomoniasis 10.2 CXCL8 IL2
45 cysticercosis 10.2 IL18 IL6
46 meconium aspiration syndrome 10.2 CXCL8 IL6
47 clonorchiasis 10.2 CXCL8 IL2
48 pyelonephritis 10.2
49 appendicitis 10.2
50 chickenpox 10.2

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


generalized muscle weakness, spasm

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CCNF CD46 IL18 IL1RN IL2 IL6

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 2 1404-90-6 14969 441141
2
Tobramycin Approved, Investigational Phase 2 32986-56-4 36294 5496
3 Immunologic Factors Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Immunoglobulins Phase 2
6 gamma-Globulins Phase 2
7 Immunoglobulin G Phase 2
8 Rho(D) Immune Globulin Phase 2
9 Antibodies Phase 2
10 Anti-Infective Agents Phase 2,Not Applicable
11 Anti-Bacterial Agents Phase 2,Not Applicable
12
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
13 Pharmaceutical Solutions Phase 1,Not Applicable
14 Vaccines Phase 1
15
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
16
Azithromycin Approved Not Applicable 83905-01-5 55185 447043
17
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
18
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
19
Protein C Approved
20 Antibiotics, Antitubercular Not Applicable
21 Clindamycin palmitate Not Applicable
22 Clindamycin phosphate Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
2 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation Recruiting NCT03721328 Phase 2
5 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT02968459 Phase 2
6 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
7 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
8 Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT03181087 Phase 1
9 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
10 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
11 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
12 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
13 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
14 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
15 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Completed NCT01790698
16 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
17 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
18 Health-related Quality of Life After Massive Burn Injury Completed NCT03660150
19 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
20 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
21 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care
22 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
23 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
24 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
25 Genetic Susceptibility to Severe Streptococcal Infections Active, not recruiting NCT01911572
26 Hyperglycemia in Surgical Infections Terminated NCT00353275 Not Applicable Strict Glycemic control;Conventional Glycemic Control
27 Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) Withdrawn NCT00896402 Not Applicable Skin antisepsis with chlorhexidine;povidone-iodine

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

41
Skin, Breast, Liver, Colon, Bone, Heart, B Cells

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 1082)
# Title Authors Year
1
A successful treatment of necrotizing fasciitis following the surgery of distal radius plate removal: A case report and literature review. ( 29642157 )
2018
2
Necrotizing fasciitis following abdominal gunshot wound. ( 29766139 )
2018
3
Necrotizing fasciitis after scrotum skin injury in an infant: A case report. ( 29561416 )
2018
4
Cervical necrotizing fasciitis: Systematic review and analysis of 1235 reported cases from the literature. ( 29934952 )
2018
5
Rapid progression and mortality of necrotizing fasciitis caused by Aeromonas hydrophila in a patient with type I open tibial fracture. ( 29699639 )
2018
6
Genomic insights of reduced teicoplanin susceptible community acquired methicillin resistant Staphylococcus aureus MRSA: Case of necrotizing fasciitis. ( 29775787 )
2018
7
Necrotizing fasciitis following minor skin surgery in a patient receiving treatment with infliximab and prednisolone. ( 29400281 )
2018
8
Monomicrobial Klebsiella pneumoniae necrotizing fasciitis: an emerging life-threatening entity. ( 29787886 )
2018
9
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
10
Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review. ( 29424798 )
2018
11
The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study. ( 29369913 )
2018
12
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases. ( 29629889 )
2018
13
Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. ( 29684366 )
2018
14
Bicipital Tendinopathy and Carpal Valgus Following a Distant Direct Thoracoabdominal Skin Flap in a German Shepherd with Necrotizing Fasciitis. ( 29757663 )
2018
15
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
16
Cervicofacial Necrotizing Fasciitis and Drugs. ( 29916971 )
2018
17
A case of periorbital necrotizing fasciitis rapidly progressing to severe multiorgan failure. ( 29765591 )
2018
18
Two fatal cases of Aeromonas dhakensis bacteremia and necrotizing fasciitis in severe dengue patients. ( 29859782 )
2018
19
Necrotizing fasciitis after a watercraft accident. ( 29883311 )
2018
20
Bilateral periorbital necrotizing fasciitis: case report. ( 29924201 )
2018
21
Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis. ( 29099935 )
2018
22
Atypical Presentation of Escherichia coli Monomicrobial Necrotizing Fasciitis in a Renal Transplant Patient: A Case Report. ( 29588065 )
2018
23
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
24
Necrotizing fasciitis following spinal anesthesia: A rare and devastating complication. ( 29416475 )
2018
25
Necrotizing fasciitis: case series and review of the literature on clinical and medico-legal diagnostic challenges. ( 29627916 )
2018
26
Scrotal Reconstruction with Integra Following Necrotizing Fasciitis. ( 29628671 )
2018
27
Necrotizing fasciitis of chest and right abdominal wall caused by acute perforated appendicitis: Case report. ( 30368121 )
2018
28
Community-acquired Disseminated Exophiala dermatitidis Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease. ( 30449799 )
2018
29
Necrotizing fasciitis following colonoscopy in the setting of ulcerative colitis. ( 30548148 )
2018
30
Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report. ( 30478748 )
2018
31
A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus. ( 30555141 )
2018
32
Necrotizing fasciitis of the lower extremity caused by perforated sigmoid diverticulitis-a case report. ( 30093996 )
2018
33
Diagnostic Performance of Initial Serum Albumin Level for Predicting In-Hospital Mortality among Necrotizing Fasciitis Patients. ( 30423847 )
2018
34
Necrotizing Fasciitis of the Breast: Case Report with Literature Review. ( 30425875 )
2018
35
Primitive necrotizing fasciitis of the thoracic wall: Fatal complication of diabetic patient. ( 30430532 )
2018
36
Necrotizing fasciitis caused by Kocuria rosea in an immunocompromised patient. ( 30443312 )
2018
37
Fungal Necrotizing Fasciitis after Penetrating Trauma. ( 30454456 )
2018
38
A New Bacterium, Lactobacillus acidophilus, Causing Necrotizing Fasciitis. ( 30454480 )
2018
39
Diagnostic pitfalls in the differentiation between pyoderma gangrenosum and necrotizing fasciitis. ( 30457495 )
2018
40
Fatal orbital necrotizing fasciitis secondary to stenotrophomonas maltophilia associated stomatitis. ( 30465891 )
2018
41
Fatal Streptoccocus canis Necrotizing Fasciitis and Myositis in a Free-Ranging Iberian Lynx ( Lynx pardinus). ( 30507336 )
2018
42
Cervicofacial Necrotizing Fasciitis in Patients with No Underlying Medical Conditions: A Review of Four Cases Seen in Twelve Months at a Nigerian Tertiary Hospital. ( 30510342 )
2018
43
Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis. ( 30510834 )
2018
44
High mortality of non-Fournier necrotizing fasciitis with Enterobacteriales: time to rethink classification? ( 30534983 )
2018
45
Periorbital Necrotizing Fasciitis Induced by Streptococcus pyogenes: A Case Report and Clarification. ( 28972883 )
2018
46
Graft healing after extensive necrotizing fasciitis of the leg in an 85-year-old man. ( 29461012 )
2018
47
Factors predicting health-related quality of life following necrotizing fasciitis. ( 29503165 )
2018
48
Necrotizing fasciitis of the lower extremity: imaging pearls and pitfalls. ( 29537292 )
2018
49
Necrotizing Fasciitis of Thoracic and Abdominal Wall with Emphysematous Pyelonephritis and Retroperitoneal Abscess. ( 29541493 )
2018
50
Successfully treated necrotizing fasciitis using extracorporeal life support combined with hemoadsorption device and continuous renal replacement therapy. ( 29546811 )
2018

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CCNF CD46 CXCL8 IL18 IL1RN IL2
2
Show member pathways
13.14 CXCL8 IL18 IL1RN IL2 IL6 LTA
3
Show member pathways
13.1 CXCL8 IL18 IL2 IL6 LTA
4
Show member pathways
12.65 CXCL8 IL18 IL2 IL6 LTA
5
Show member pathways
12.42 CD46 CXCL8 IL18 IL2 IL6 LTA
6 12.01 CXCL8 IL1RN IL6
7
Show member pathways
11.95 CXCL8 IL18 IL1RN IL6
8
Show member pathways
11.93 CXCL8 IL18 IL2 IL6 LTA
9
Show member pathways
11.91 CXCL8 IL18 IL2 IL6
10 11.86 CXCL8 IL2 IL6
11 11.83 CXCL8 IL18 IL6
12
Show member pathways
11.78 IL18 IL2 IL6 LTA
13 11.73 CXCL8 IL18 IL2
14 11.71 CXCL8 IL18 IL6
15 11.68 CXCL8 IL18 IL6
16
Show member pathways
11.64 CXCL8 IL2 LTA
17 11.63 CXCL8 IL2 IL6
18 11.6 IL18 IL2 LTA
19
Show member pathways
11.47 CXCL8 IL2 IL6
20 11.37 CXCL8 IL18 IL6
21 11.31 IL18 IL1RN IL2 IL6
22 11.3 CXCL8 IL18 IL6
23 11.2 IL18 IL6
24 11.18 CXCL8 IL6
25 11.15 IL18 IL6
26 11.1 IL2 IL6
27 11.08 IL18 IL2
28 11.04 IL2 LTA
29 10.89 CXCL8 IL6
30 10.78 CXCL8 IL18 IL2 IL6 LTA
31 10.61 CXCL8 IL18 IL1RN IL6
32 10.58 CXCL8 IL18 IL2 IL6 LTA

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.84 CXCL8 IL18 IL1RN IL6
2 cell-cell signaling GO:0007267 9.76 IL18 IL2 LTA
3 cellular response to lipopolysaccharide GO:0071222 9.73 CXCL8 IL1RN IL6
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 IL18 IL2 IL6
5 natural killer cell activation GO:0030101 9.58 IL18 IL2
6 positive regulation of activated T cell proliferation GO:0042104 9.57 IL18 IL2
7 positive regulation of glial cell proliferation GO:0060252 9.55 IL6 LTA
8 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL18 IL1RN IL2 IL6
9 positive regulation of T cell proliferation GO:0042102 9.54 CD46 IL2 IL6
10 positive regulation of interleukin-17 production GO:0032740 9.52 IL18 IL2
11 positive regulation of immunoglobulin secretion GO:0051024 9.51 IL2 IL6
12 positive regulation of regulatory T cell differentiation GO:0045591 9.49 CD46 IL2
13 neutrophil activation GO:0042119 9.48 CXCL8 IL18
14 positive regulation of neuroinflammatory response GO:0150078 9.43 IL18 IL6
15 positive regulation of interferon-gamma production GO:0032729 9.43 IL18 IL2 LTA
16 immune response GO:0006955 9.43 CXCL8 IL18 IL1RN IL2 IL6 LTA
17 positive regulation of tissue remodeling GO:0034105 9.4 IL18 IL2
18 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
19 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....