MCID: NCR007
MIFTS: 48

Necrotizing Fasciitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrotizing Fasciitis

MalaCards integrated aliases for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 73 20 15 70 32
Fasciitis, Necrotizing 44

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD9CM 34 728.86
MeSH 44 D019115
NCIt 50 C84916
SNOMED-CT 67 186428007
ICD10 32 M72.6
UMLS 70 C0238124

Summaries for Necrotizing Fasciitis

GARD : 20 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue.

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fasciitis and cellulitis, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Necrotizing Fasciitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and colon, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 73 Necrotizing fasciitis (NF), also known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 841)
# Related Disease Score Top Affiliating Genes
1 fasciitis 32.0 MYOM2 LTA IL6 IL2 IL1RN IL18
2 cellulitis 31.4 MYOM2 IL6 CRP CAMP ALB
3 gas gangrene 31.4 PRF1 IL6 CRP
4 streptococcal toxic-shock syndrome 31.2 MYOM2 LTA IL6 IL2 CXCL8
5 diverticulitis 31.1 IL6 CRP ALB
6 chickenpox 31.0 PRF1 IL6 IL2 CRP ALB
7 enterocolitis 31.0 IL6 CXCL8 CD46
8 noma 30.8 IL18 CXCL8 ALB
9 myositis 30.7 IL6 IL2 IL1B CXCL8
10 peripheral vascular disease 30.7 IL6 IL18 H2AC18 CRP ALB
11 pyomyositis 30.7 TST MYOM2 CRP
12 toxic shock syndrome 30.7 MYOM2 LTA IL6 IL2 IL1RN IL1B
13 compartment syndrome 30.7 PLG IL6 CRP ALB
14 disseminated intravascular coagulation 30.6 PLG IL6 FN1 CRP
15 intestinal perforation 30.6 IL6 CRP ALB
16 pyoderma 30.6 MYOM2 IL1B CXCL8 CRP
17 pleural empyema 30.6 PLG IL6 CRP ALB
18 varicose veins 30.6 IL6 FN1 CXCL8
19 aspiration pneumonia 30.5 IL6 CRP ALB
20 thrombophlebitis 30.5 PLG CRP ALB
21 pericardial effusion 30.5 IL6 CRP ALB
22 erysipelas 30.5 MYOM2 IL6 IL2 IL1B CRP
23 substance abuse 30.4 IL6 H2AC18 CRP ALB
24 macrophage activation syndrome 30.4 PRF1 IL18 CRP
25 cystitis 30.4 IL6 IL2 IL18 CXCL8 CRP
26 pancytopenia 30.3 PRF1 IL6 H2AC18 CRP
27 osteomyelitis 30.3 IL6 IL1RN IL1B CXCL8 CRP
28 intestinal obstruction 30.3 IL6 CRP ALB
29 conjunctivitis 30.3 PLG IL6 IL2 CXCL8
30 systemic autoimmune disease 30.3 IL6 CRP
31 pulmonary tuberculosis 30.3 IL6 IL2 IL18 ALB
32 sclerosing cholangitis 30.3 IL6 IL2 CXCL8 ALB
33 viral pneumonia 30.3 IL6 CXCL8 CRP
34 peritonitis 30.3 IL6 IL1B IL18 CXCL8 CRP ALB
35 rheumatic fever 30.3 MYOM2 IL6 IL2 ALB
36 pustulosis of palm and sole 30.3 IL1RN CXCL8 CRP
37 endocarditis 30.3 IL6 CXCL8 CRP ALB
38 breast abscess 30.3 ETV5 CRP
39 appendicitis 30.2 IL6 IL2 IL1B CXCL8 CRP ALB
40 acute kidney tubular necrosis 30.2 IL6 IL18 ALB
41 ecthyma 30.2 MYOM2 CRP
42 liver cirrhosis 30.2 IL6 IL2 IL1B CXCL8 CRP ALB
43 aspiration pneumonitis 30.2 CXCL8 CRP ALB
44 epidural abscess 30.2 CRP ALB
45 pyelonephritis 30.2 IL6 IL1B CXCL8 CRP ALB
46 hemopericardium 30.1 PLG CRP
47 dengue hemorrhagic fever 30.1 IL6 CXCL8 ALB
48 cholangitis 30.1 IL6 IL2 CXCL8 CRP ALB
49 intermittent claudication 30.1 IL6 CRP ALB
50 retinal artery occlusion 30.1 PLG IL6 CXCL8 CRP

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


generalized muscle weakness; spasm

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.24 ALB CD46 CRP FN1 IL18 IL1B
2 hematopoietic system MP:0005397 10.1 CAMP FN1 IL18 IL1B IL1RN IL2
3 immune system MP:0005387 10.1 ALB CAMP CRP FN1 IL18 IL1B
4 mortality/aging MP:0010768 9.8 ALB CAMP ETV5 FN1 IL18 IL1B
5 liver/biliary system MP:0005370 9.76 ALB FN1 IL2 IL6 LTA PLG
6 neoplasm MP:0002006 9.17 ALB FN1 IL1B IL2 IL6 PLG

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 2
2 Antibodies Phase 2
3 Immunologic Factors Phase 2
4 gamma-Globulins Phase 2
5 Immunoglobulin G Phase 2
6 Immunoglobulins, Intravenous Phase 2
7 Rho(D) Immune Globulin Phase 2
8
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10
Protein C Approved
11 Anti-Bacterial Agents
12 Anti-Infective Agents
13 Sodium hypochlorite
14 Eusol

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study of AB103 as Compared to Placebo in Patients With Necrotizing Soft Tissue Infections. ACCUTE (AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections) Completed NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 A Prospective, Non-Randomized, Open-Label Study on the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
4 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
5 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Unknown status NCT02169128
6 Genetic Susceptibility to Invasive Streptococcal Disease Unknown status NCT01911572
7 Raised Serum Lactate as a Marker of Necrotizing Fasciitis; a Consecutive Prospective Review. Completed NCT01739959
8 Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures That Dictate Severity of Tissue Infection Completed NCT01790698
9 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
10 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
11 Open Label, Single Center Study to Evaluate Higher Doses of Daptomycin in the Treatment of Patients With Severe Necrotizing Skin and Soft Tissue Infections. Completed NCT00261807 Daptomycin 6mg/kg/day
12 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
13 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
14 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
15 A Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of the RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction Recruiting NCT04091672
16 A Comparative Study Between the Use of Topical Honey and EUSOL Dressing in Necrotizing Fascitis Wounds Recruiting NCT04831112 Honey
17 Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis (DHBN-FN) Mono- or Multi-microbial Streptococcus Beta-haemolytic: Study of Carriage in Patients and Their Entourage Not yet recruiting NCT03976024
18 Studies on Hyperglycemia in Surgical Infections Terminated NCT00353275 Strict Glycemic control;Conventional Glycemic Control

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

40
Skin, Neutrophil, Colon, Myeloid, Bone Marrow, Spinal Cord, Eye

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 3740)
# Title Authors PMID Year
1
A thigh urinary fistula following radical prostatectomy and external beam radiation therapy for prostate cancer: a case report. 61
33511034 2021
2
Assessment of Outcomes After Limberg Flap Reconstruction for Scrotal Defects in Patients With Fournier's Gangrene. 61
33793411 2021
3
Atypical Presentation of Severe Fungal Necrotizing Fasciitis in a Patient with X-Linked Agammaglobulinemia. 61
33713249 2021
4
Healing of Chronic Wounds by Copper Oxide-Impregnated Wound Dressings-Case Series. 61
33809898 2021
5
The combined score of quick SOFA and the charlson comorbidity index could be a poor prognostic indicator for in-hospital mortality among patients with necrotizing fasciitis. 61
33678549 2021
6
Huge carbuncle leading to necrotizing fasciitis in the COVID-19 pandemic era. 61
33768893 2021
7
A case of cervical fasciitis complicated by mediastinitis and pre-peritoneal abscess: the role of video-assisted thoracoscopic surgery. 61
33642717 2021
8
Necrotizing Fasciitis Shock Syndrome by Group A Hemolytic Streptococcus: Report of 6 Cases and Clinical Management. 61
33739051 2021
9
Necrotizing fasciitis of the upper extremity: a retrospective analysis of 19 cases. 61
33812083 2021
10
Aeromonas sobria necrotizing fasciitis complicating neonatal sclerosing cholangitis. 61
33810916 2021
11
High-throughput 16S rDNA sequencing assisting in the detection of bacterial pathogen candidates: a fatal case of necrotizing fasciitis in a child. 61
32895762 2021
12
Negative pressure wound therapy with instillation and dwell time in the wound management of necrotizing fasciitis. 61
33707160 2021
13
Post-partum necrotizing fasciitis of the breast: a case study. 61
33755296 2021
14
Necrotizing fasciitis secondary to lake water inoculation with Aeromonas sobria: A case report. 61
33725868 2021
15
Early and aggressive surgical debridement and negative pressure wound therapy to treat necrotizing fasciitis in three dogs. 61
33724500 2021
16
Elevated methaemoglobin in a critically ill patient as a result of hydrogen peroxide exposure: A case study. 61
33626185 2021
17
Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential. 61
33541265 2021
18
Retrograde nailing, trabecular metal implant and use of bone marrow aspirate concentrate after failed ankle joint replacement. 61
32273230 2021
19
Necrotizing Fasciitis of the Right Lower Extremity from Ruptured Appendicitis: Case Report. 61
33587485 2021
20
Risk factors associated with necrotizing fasciitis of the lower limbs: A multicenter case-control study. 61
33558036 2021
21
Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. 61
33598888 2021
22
Cervical Necrotizing Fasciitis, Diagnosis and Treatment of a Rare Life-Threatening Infection. 61
33570428 2021
23
Near-fatal poisoning after ricin injection. 61
32475181 2021
24
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
25
Fournier's gangrene as a rare complication in patient with uncontrolled type 2 diabetes treated with surgical debridement: A case report and literature review. 61
33757263 2021
26
Necrotizing fasciitis caused by diabetic foot. 61
33207273 2021
27
Early detecting cervical necrotizing fasciitis from deep neck infections: a study of 550 patients. 61
33559743 2021
28
Utility of the Laboratory Risk Indicator for Necrotizing Fasciitis Score: Comorbid Conditions Do Matter. 61
33544051 2021
29
Catastrophic appendicitis operation, successful repair in tertiary limited resources hospital: A case report. 61
33489109 2021
30
Orchidopexy and Split-thickness Skin Graft for Scrotal Defects After Necrotizing Fasciitis. 61
33581235 2021
31
Different types of bullae of limbs with necrotizing fasciitis predict different outcome: a prospective study. 61
33389697 2021
32
Management protocol for Fournier's gangrene in sanitary regime caused by SARS-CoV-2 pandemic: A case report. 61
33644187 2021
33
Pyoderma gangrenosum underrepresentation in non-dermatological literature. 61
31913849 2021
34
An extensive pyoderma gangrenosum mimicking necrotizing fasciitis: An unusual case report. 61
33691271 2021
35
Predictive ability of LRINEC score in the prediction of limb loss and mortality in diabetic foot infection. 61
33556651 2021
36
Photobiomodulation to Treat Necrotizing Fasciitis. 61
33464777 2021
37
Abdominoperineal Resection with Absorbable Mesh Repair of Perineal Defect for Fournier's Gangrene: A Case Report. 61
33664599 2021
38
Surgical Strategies: Necrotizing Fasciitis of the Foot and Ankle Treated With Dermal Regeneration Matrix for Limb Salvage. 61
32975443 2021
39
The Association Between Body Mass Index and the Risk of Hospitalization and Mortality due to Infection: A Prospective Cohort Study. 61
33511222 2021
40
Challenging Treatment of a Female Patient with Extensive Fournier's Gangrene - Case Report. 61
33646941 2021
41
Non-Necrotizing Bullous Cellulitis and Bacteremia: A Rare Presentation of the Shewanella Algae Infection. 61
33628648 2021
42
A Case of Subacute Necrotizing Fasciitis due to Serratia marcescens. 61
33584969 2021
43
Usefulness of serum procalcitonin for necrotizing fasciitis as an early diagnostic tool. 61
33454216 2021
44
Catastrophic complications from filler injection on external genitalia. 61
33503739 2021
45
Acute Perforated Appendicitis Complicated by Necrotizing Fasciitis and Bladder Perforation. 61
33489640 2021
46
Management of a Complex Peristomal Fistula: A Case Study. 61
33427814 2021
47
Analyzing Outcomes Among Older Adults With Necrotizing Soft-Tissue Infections in the United States. 61
32818779 2021
48
Evaluation of Linezolid Pharmacokinetics in Critically Ill Obese Patients with Severe Skin and Soft Tissue Infections. 61
33257446 2021
49
Evaluation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for detecting necrotizing soft tissue infections in patients with diabetes and lower extremity infection. 61
33096188 2021
50
Noma and Necrotizing Fasciitis of the Face and Neck. 61
33517575 2021

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 LTA IL6 IL2 IL1RN IL1B IL18
2
Show member pathways
13.34 LTA IL6 IL2 IL1RN IL1B IL18
3
Show member pathways
12.84 PRF1 LTA IL6 IL2 IL1B CXCL8
4
Show member pathways
12.71 PLG IL6 IL2 IL1B IL18 CXCL8
5
Show member pathways
12.7 IL6 IL1RN IL1B IL18 CXCL8
6
Show member pathways
12.53 PLG IL6 IL2 IL1B IL18 FN1
7
Show member pathways
12.3 LTA IL6 IL2 IL18 CXCL8
8
Show member pathways
12.22 LTA IL6 IL2 IL1B IL18 CXCL8
9 12.21 IL6 IL1B IL18 CAMP
10 12.2 IL6 IL1B IL18 CXCL8 CAMP
11
Show member pathways
12.18 PLG IL6 IL2 IL1B CRP ALB
12
Show member pathways
12.17 IL6 IL1B FN1 CXCL8
13 12.15 IL6 IL1RN IL1B CXCL8
14 12 IL6 IL2 IL1B CXCL8
15
Show member pathways
11.97 IL2 IL1B IL18 ETV5
16 11.92 IL6 IL1B FN1 CXCL8
17 11.9 IL6 IL1B FN1 CXCL8
18 11.88 IL6 IL1B FN1 CXCL8
19 11.86 IL6 IL1B IL18 FN1 CXCL8
20 11.85 IL6 IL1B IL18 CXCL8
21
Show member pathways
11.78 LTA IL2 CXCL8
22 11.77 IL6 IL2 CXCL8
23 11.76 LTA IL2 IL1B IL18
24 11.74 IL6 IL1B CXCL8
25 11.72 IL6 IL2 IL1B
26
Show member pathways
11.67 PRF1 LTA IL2
27 11.64 IL6 IL1B CXCL8
28 11.62 PLG FN1 CXCL8
29
Show member pathways
11.61 IL6 IL2 IL1B CXCL8
30 11.57 IL6 IL2 IL1B IL18 FN1 CXCL8
31
Show member pathways
11.54 LTA IL6 IL2 IL1B IL18
32 11.53 IL6 IL1B IL18 CXCL8
33 11.5 PLG IL6 FN1
34 11.43 IL6 IL1B IL18 CXCL8
35 11.38 IL6 IL1B IL18
36 11.31 IL6 IL1B IL18
37 11.24 IL6 IL2 IL1B
38 11.07 PRF1 IL2 IL18 ETV5
39 10.94 LTA IL6 IL2 IL1B IL18 FN1
40 10.74 IL6 FN1 CXCL8 CRP
41 10.71 IL6 IL1RN IL1B IL18 CXCL8
42 10.5 IL1B IL18

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 PRF1 PLG LTA IL6 IL2 IL1RN
2 extracellular space GO:0005615 9.44 TST PLG LTA IL6 IL2 IL1RN
3 platelet alpha granule lumen GO:0031093 9.33 PLG FN1 ALB

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 SPEG PLG IL6 IL1B CXCL8
2 cell-cell signaling GO:0007267 9.91 LTA IL2 IL1B IL18
3 positive regulation of gene expression GO:0010628 9.91 IL6 IL1B IL18 FN1 CXCL8 CRP
4 cellular protein metabolic process GO:0044267 9.9 PLG IL6 FN1 ALB
5 immune response GO:0006955 9.87 LTA IL6 IL2 IL1RN IL1B IL18
6 cellular response to lipopolysaccharide GO:0071222 9.84 IL6 IL1B CXCL8 CAMP
7 defense response to Gram-positive bacterium GO:0050830 9.8 LTA IL6 CRP CAMP
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IL6 IL2 IL18
9 positive regulation of interferon-gamma production GO:0032729 9.76 LTA IL2 IL1B IL18
10 positive regulation of T cell proliferation GO:0042102 9.73 IL6 IL2 IL1B CD46
11 inflammatory response GO:0006954 9.7 LIAS IL6 IL1RN IL1B IL18 CXCL8
12 positive regulation of interleukin-17 production GO:0032740 9.65 IL6 IL2 IL18
13 negative regulation of lipid storage GO:0010888 9.58 IL6 CRP
14 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 IL1B IL18
15 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.57 IL6 IL1RN
16 vascular endothelial growth factor production GO:0010573 9.56 IL6 IL1B
17 acute-phase response GO:0006953 9.56 IL6 IL1RN FN1 CRP
18 positive regulation of tissue remodeling GO:0034105 9.55 IL2 IL18
19 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.52 IL1B IL18
20 interaction with symbiont GO:0051702 9.51 PLG FN1
21 cytokine-mediated signaling pathway GO:0019221 9.5 IL6 IL2 IL1RN IL1B IL18 FN1
22 positive regulation of glial cell proliferation GO:0060252 8.92 LTA IL6 IL1B ETV5

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 LTA IL6 IL2 IL1RN IL1B IL18

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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