Aliases & Classifications for Necrotizing Fasciitis

MalaCards integrated aliases for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 76 53 3 15 73
Fasciitis, Necrotizing 44

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD10 33 M72.6
ICD9CM 35 728.86
MeSH 44 D019115
NCIt 50 C84916
SNOMED-CT 68 186428007 52486002
UMLS 73 C0238124

Summaries for Necrotizing Fasciitis

NIH Rare Diseases : 53 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue.

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to noma and fasciitis, and has symptoms including spasm and generalized muscle weakness. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and colon, and related phenotype is cardiovascular system.

CDC : 3 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Wikipedia : 76 Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 noma 30.9 CXCL8 IL18
2 fasciitis 30.9 CD46 CXCL8 IL18 IL6 RPS17
3 perinatal necrotizing enterocolitis 30.1 CXCL8 IL6
4 prostatitis 29.9 CXCL8 IL2 IL6
5 adult-onset still's disease 29.9 IL18 IL1RN IL6
6 conjunctivitis 29.9 CXCL8 IL2 IL6
7 colitis 29.8 CXCL8 IL2 IL6
8 spondylitis 29.7 IL1RN IL6 LTA
9 tonsillitis 29.5 CXCL8 IL2 IL6 LTA
10 pharyngitis 29.4 CXCL8 MYOM2
11 arthritis 29.3 CXCL8 IL18 IL1RN IL6 LTA
12 rheumatoid arthritis 29.0 CXCL8 IL18 IL1RN IL2 IL6
13 systemic lupus erythematosus 28.9 IL18 IL2 IL6 LTA
14 aplastic anemia 28.9 IL2 IL6 RPS17
15 toxic shock syndrome 28.8 CXCL8 IL2 IL6 LTA MYOM2
16 psoriasis 28.8 CXCL8 IL18 IL2 IL6 LTA
17 streptococcal toxic-shock syndrome 28.6 CXCL8 IL2 IL6 LTA MYOM2
18 diabetes mellitus 28.0 IL1RN IL2 IL6 LTA
19 fournier gangrene 11.5
20 sapho syndrome 10.8 CXCL8 IL18
21 recurrent corneal erosion 10.7 CXCL8 IL6
22 bagassosis 10.7 CXCL8 IL6
23 acute transverse myelitis 10.7 CXCL8 IL6
24 denture stomatitis 10.7 CXCL8 IL6
25 papillary conjunctivitis 10.7 CXCL8 IL6
26 funisitis 10.7 CXCL8 IL6
27 stachybotrys chartarum 10.7 IL18 IL6
28 listeria meningitis 10.7 IL18 LTA
29 acute monoblastic leukemia 10.7 CXCL8 IL6
30 meconium aspiration syndrome 10.7 CXCL8 IL6
31 cysticercosis 10.7 IL18 IL6
32 toxicodendron dermatitis 10.7 CXCL8 IL2
33 null-cell leukemia 10.6 IL6 LTA
34 vaginal disease 10.6 CXCL8 IL6
35 louse-borne relapsing fever 10.6 CXCL8 IL6
36 preterm premature rupture of the membranes 10.6 CXCL8 IL6
37 endometrial disease 10.6 CXCL8 IL6
38 transverse myelitis 10.6 CXCL8 IL6
39 trichomoniasis 10.6 CXCL8 IL2
40 schnitzler syndrome 10.6 IL18 IL1RN
41 juvenile spondyloarthropathy 10.6 IL2 LTA
42 vaginitis 10.6 CXCL8 IL6
43 clonorchiasis 10.6 CXCL8 IL2
44 pleural tuberculosis 10.6 CXCL8 IL18
45 crohn's colitis 10.6 CXCL8 IL2
46 pouchitis 10.6 CXCL8 IL1RN
47 bacteriuria 10.6 CXCL8 IL6
48 radiculopathy 10.6 CXCL8 IL6
49 microscopic colitis 10.6 IL2 IL6
50 cervicitis 10.6

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


spasm, generalized muscle weakness

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 IL1RN IL2 IL6 LTA CCNF CD46

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulin G Phase 2
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Immunoglobulins, Intravenous Phase 2
7
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
8 Vaccines Phase 1
9 Pharmaceutical Solutions Phase 1,Not Applicable
10
Azithromycin Approved Not Applicable 83905-01-5 55185 447043
11
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
12
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
13
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
14
Protein C Approved
15 Clindamycin palmitate Not Applicable
16 Clindamycin phosphate Not Applicable
17 Anti-Bacterial Agents Not Applicable
18 Antibiotics, Antitubercular Not Applicable
19 Anti-Infective Agents Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
2 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT02968459 Phase 2
5 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
6 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
7 Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT03181087 Phase 1
8 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
9 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
10 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
11 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
12 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
13 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
14 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Completed NCT01790698
15 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
16 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
17 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
18 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
19 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care
20 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
21 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
22 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
23 Genetic Susceptibility to Severe Streptococcal Infections Active, not recruiting NCT01911572
24 Hyperglycemia in Surgical Infections Terminated NCT00353275 Not Applicable Strict Glycemic control;Conventional Glycemic Control
25 Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) Withdrawn NCT00896402 Not Applicable Skin antisepsis with chlorhexidine;povidone-iodine

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

41
Skin, Eye, Colon, Liver, Kidney, Tonsil, Spinal Cord

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 745)
# Title Authors Year
1
A successful treatment of necrotizing fasciitis following the surgery of distal radius plate removal: A case report and literature review. ( 29642157 )
2018
2
Necrotizing fasciitis following abdominal gunshot wound. ( 29766139 )
2018
3
Necrotizing fasciitis after scrotum skin injury in an infant: A case report. ( 29561416 )
2018
4
Cervical necrotizing fasciitis: Systematic review and analysis of 1235 reported cases from the literature. ( 29934952 )
2018
5
Rapid progression and mortality of necrotizing fasciitis caused by Aeromonas hydrophila in a patient with type I open tibial fracture. ( 29699639 )
2018
6
Genomic insights of reduced teicoplanin susceptible community acquired methicillin resistant Staphylococcus aureus MRSA: Case of necrotizing fasciitis. ( 29775787 )
2018
7
Necrotizing fasciitis following minor skin surgery in a patient receiving treatment with infliximab and prednisolone. ( 29400281 )
2018
8
Monomicrobial Klebsiella pneumoniae necrotizing fasciitis: an emerging life-threatening entity. ( 29787886 )
2018
9
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
10
Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review. ( 29424798 )
2018
11
The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study. ( 29369913 )
2018
12
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases. ( 29629889 )
2018
13
Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. ( 29684366 )
2018
14
Bicipital Tendinopathy and Carpal Valgus Following a Distant Direct Thoracoabdominal Skin Flap in a German Shepherd with Necrotizing Fasciitis. ( 29757663 )
2018
15
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
16
Cervicofacial Necrotizing Fasciitis and Drugs. ( 29916971 )
2018
17
A case of periorbital necrotizing fasciitis rapidly progressing to severe multiorgan failure. ( 29765591 )
2018
18
Two fatal cases of Aeromonas dhakensis bacteremia and necrotizing fasciitis in severe dengue patients. ( 29859782 )
2018
19
Necrotizing fasciitis after a watercraft accident. ( 29883311 )
2018
20
Bilateral periorbital necrotizing fasciitis: case report. ( 29924201 )
2018
21
Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis. ( 29099935 )
2018
22
Atypical Presentation of Escherichia coli Monomicrobial Necrotizing Fasciitis in a Renal Transplant Patient: A Case Report. ( 29588065 )
2018
23
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
24
Necrotizing fasciitis following spinal anesthesia: A rare and devastating complication. ( 29416475 )
2018
25
Necrotizing fasciitis: case series and review of the literature on clinical and medico-legal diagnostic challenges. ( 29627916 )
2018
26
Scrotal Reconstruction with Integra Following Necrotizing Fasciitis. ( 29628671 )
2018
27
Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. ( 29854478 )
2018
28
A case of disseminated cryptococcosis with necrotizing fasciitis in a non-HIV patient. ( 29123908 )
2017
29
Necrotizing Fasciitis: A Rare Complication of Acute Necrotizing Pancreatitis. ( 28764243 )
2017
30
Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report. ( 29179775 )
2017
31
Negative Pressure Wound Therapy for a Giant Wound Secondary to Malignancy-induced Necrotizing Fasciitis: Case Report and Review of the Literature. ( 28862979 )
2017
32
Rapid identification of pathogens responsible for necrotizing fasciitis on an integrated microfluidic system. ( 29282420 )
2017
33
Hyperbaric oxygen may only be optional in head and neck necrotizing fasciitis: a retrospective analysis of 43 cases and review of the literature. ( 28644692 )
2017
34
Pasteurella multocida ecthyma complicated by necrotizing fasciitis. ( 28541874 )
2017
35
Re: Laboratory Risk Indicator for Necrotizing Fasciitis score for early diagnosis of necrotizing fasciitis in Darwin. ( 29205823 )
2017
36
Clostridium perfringens necrotizing fasciitis with massive hemolysis. ( 28782816 )
2017
37
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases. ( 29311423 )
2017
38
Retroperitoneal Necrotizing Fasciitis from Fournier's Gangrene in an Immunocompromised Patient. ( 29333313 )
2017
39
Cervical-thoracic necrotizing fasciitis of odontogenic origin in a diabetic patient: a case report. ( 28682278 )
2017
40
Antimicrobial treatment of necrotizing fasciitis and septic polyarthritis in a cat associated with Streptococcus canis infection. ( 28776781 )
2017
41
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
42
Presenting features of extremity necrotizing fasciitis in the pediatric patient: a case-control analysis. ( 28877051 )
2017
43
Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. ( 28084021 )
2017
44
Cervical Necrotizing Fasciitis of Odontogenic Origin and Hyperbaric Oxygen Therapy. ( 28857997 )
2017
45
Chest Necrotizing Fasciitis with Mediastinitis. ( 28674375 )
2017
46
Cervical necrotizing fasciitis: an overlooked diagnosis of a fatal disease. ( 29105542 )
2017
47
Necrotizing fasciitis associated with primary cutaneous B-cell lymphoma. A case report. ( 29205142 )
2017
48
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
49
First Necrotizing Fasciitis Caused by<i>Haemophilus influenza</i>Serotype a. ( 29124073 )
2017
50
Response to Re: Laboratory Risk Indicator for Necrotizing Fasciitis score for early diagnosis of necrotizing fasciitis in Darwin. ( 29205831 )
2017

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCNF CD46 CXCL8 IL18 IL1RN IL2
2
Show member pathways
13.12 CXCL8 IL18 IL1RN IL2 IL6 LTA
3
Show member pathways
13.09 CXCL8 IL18 IL2 IL6 LTA
4
Show member pathways
12.6 CXCL8 IL18 IL2 IL6 LTA
5
Show member pathways
12.15 CXCL8 IL18 IL2 IL6 LTA
6
Show member pathways
12.12 CD46 CXCL8 IL18 IL2 IL6 LTA
7 11.99 CXCL8 IL1RN IL6
8
Show member pathways
11.9 IL18 IL2 IL6 LTA
9
Show member pathways
11.89 CXCL8 IL18 IL2 IL6
10 11.84 CXCL8 IL2 IL6
11 11.8 CXCL8 IL18 IL6
12
Show member pathways
11.8 CXCL8 IL18 IL1RN IL6
13 11.7 CXCL8 IL18 IL2
14 11.68 CXCL8 IL18 IL6
15 11.63 CXCL8 IL18 IL6
16
Show member pathways
11.61 CXCL8 IL2 LTA
17 11.58 CXCL8 IL2 IL6
18 11.56 IL18 IL2 LTA
19
Show member pathways
11.41 CXCL8 IL2 IL6
20 11.32 CXCL8 IL18 IL6
21 11.23 CXCL8 IL18 IL6
22 11.19 IL18 IL6
23 11.17 CXCL8 IL6
24 11.14 IL18 IL6
25 11.1 IL2 IL6
26 11.06 IL18 IL2
27 11.03 IL2 LTA
28 10.87 CXCL8 IL6
29 10.61 CXCL8 IL18 IL1RN IL6

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.83 CXCL8 IL18 IL1RN IL6
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL18 IL2 IL6
3 positive regulation of activated T cell proliferation GO:0042104 9.56 IL18 IL2
4 positive regulation of leukocyte chemotaxis GO:0002690 9.55 CXCL8 IL6
5 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL18 IL1RN IL2 IL6
6 natural killer cell activation GO:0030101 9.54 IL18 IL2
7 positive regulation of T cell proliferation GO:0042102 9.54 CD46 IL2 IL6
8 positive regulation of interleukin-17 production GO:0032740 9.51 IL18 IL2
9 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL2 IL6
10 neutrophil activation GO:0042119 9.48 CXCL8 IL18
11 positive regulation of regulatory T cell differentiation GO:0045591 9.46 CD46 IL2
12 positive regulation of tissue remodeling GO:0034105 9.43 IL18 IL2
13 positive regulation of interferon-gamma production GO:0032729 9.43 IL18 IL2 LTA
14 immune response GO:0006955 9.43 CXCL8 IL18 IL1RN IL2 IL6 LTA
15 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.32 IL1RN IL6
16 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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