MCID: NCR007
MIFTS: 51

Necrotizing Fasciitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrotizing Fasciitis

MalaCards integrated aliases for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 77 54 15 74 3
Fasciitis, Necrotizing 45 3

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD9CM 36 728.86
MeSH 45 D019115
NCIt 51 C84916
SNOMED-CT 69 52486002
ICD10 34 M72.6
UMLS 74 C0238124

Summaries for Necrotizing Fasciitis

NIH Rare Diseases : 54 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue.

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fasciitis and noma, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon, and related phenotype is cardiovascular system.

CDC : 3 Bacteria called group A Streptococcus (group A strep) can cause many different infections. Some of these are common, relatively minor infections, like strep throat. Others are less common, but very serious and even deadly. People can easily spread group A strep to other people. Practicing good hygiene, like washing your hands often, is the best way to protect yourself from group A strep infections.

Wikipedia : 77 Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 fasciitis 32.2 CD46 CXCL8 IL18 IL6
2 noma 30.5 CXCL8 IL18
3 osteomyelitis 30.5 CXCL8 IL1RN IL6
4 toxic shock syndrome 30.2 CXCL8 IL2 IL6 LTA MYOM2
5 orbital cellulitis 30.1 IL1RN LTA
6 crohn's colitis 30.1 CXCL8 IL2
7 arthritis 30.1 CXCL8 IL18 IL1RN IL6 LTA
8 colitis 30.1 CXCL8 IL2 IL6
9 streptococcal toxic-shock syndrome 30.0 CXCL8 IL2 IL6 LTA MYOM2
10 rheumatoid arthritis 29.9 CXCL8 IL18 IL1RN IL2 IL6
11 adult-onset still's disease 29.9 IL18 IL1RN IL6
12 conjunctivitis 29.9 CXCL8 IL2 IL6
13 ulcerative colitis 29.9 CXCL8 IL2 IL6
14 tonsillitis 29.8 CXCL8 IL2 IL6 LTA
15 spondylitis 29.8 IL1RN IL6 LTA
16 diabetes mellitus 29.5 IL1RN IL2 IL6 LTA
17 myeloma, multiple 29.5 CXCL8 IL2 IL6 MYOM2
18 aplastic anemia 29.3 IL2 IL6 LTA
19 fournier gangrene 11.6
20 cellulitis 10.4
21 necrotizing soft tissue infection 10.4
22 diverticulitis 10.4
23 mediastinitis 10.4
24 lupus erythematosus 10.4
25 sapho syndrome 10.4 CXCL8 IL18
26 systemic lupus erythematosus 10.4
27 myositis 10.4
28 gas gangrene 10.4
29 pyoderma 10.4
30 recurrent corneal erosion 10.3 CXCL8 IL6
31 bagassosis 10.3 CXCL8 IL6
32 acute transverse myelitis 10.3 CXCL8 IL6
33 transverse myelitis 10.3 CXCL8 IL6
34 appendicitis 10.3
35 pyoderma gangrenosum 10.3
36 denture stomatitis 10.3 CXCL8 IL6
37 papillary conjunctivitis 10.3 CXCL8 IL6
38 funisitis 10.3 CXCL8 IL6
39 stachybotrys chartarum 10.3 IL18 IL6
40 listeria meningitis 10.3 IL18 LTA
41 acute monoblastic leukemia 10.3 CXCL8 IL6
42 toxicodendron dermatitis 10.3 CXCL8 IL2
43 meconium aspiration syndrome 10.3 CXCL8 IL6
44 null-cell leukemia 10.3 IL6 LTA
45 cysticercosis 10.3 IL18 IL6
46 louse-borne relapsing fever 10.3 CXCL8 IL6
47 juvenile spondyloarthropathy 10.3 IL2 LTA
48 crohn's disease 10.3
49 haemophilus influenzae 10.3
50 endometrial disease 10.3 CXCL8 IL6

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


generalized muscle weakness, spasm

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.23 CCNF CD46 IL18 IL1RN IL2 IL6

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
2 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
3 Anti-Infective Agents, Local Phase 4,Not Applicable
4 Disinfectants Phase 4,Not Applicable
5
Azithromycin Approved Phase 3,Not Applicable 83905-01-5 55185 447043
6
Vancomycin Approved Phase 2 1404-90-6 441141 14969
7
Tobramycin Approved, Investigational Phase 2 32986-56-4 5496 36294
8 Antibodies Phase 2
9 Immunologic Factors Phase 2
10 gamma-Globulins Phase 2
11 Immunoglobulin G Phase 2
12 Immunoglobulins, Intravenous Phase 2
13 Rho(D) Immune Globulin Phase 2
14 Immunoglobulins Phase 2
15
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
16 Pharmaceutical Solutions Phase 1,Not Applicable
17 Vaccines Phase 1
18
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
19
Cefazolin Approved Not Applicable 25953-19-9 656510 33255
20
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
21
Protein C Approved
22 Clindamycin phosphate Not Applicable
23 Clindamycin palmitate Not Applicable
24 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
2 Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery Not yet recruiting NCT03887299 Phase 4
3 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
4 Azithromycin-Prevention in Labor Use Study (A-PLUS) Not yet recruiting NCT03871491 Phase 3 Azithromycin;Placebo
5 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
6 Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation Recruiting NCT03721328 Phase 2
7 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT02968459 Phase 2
8 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
9 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
10 Safety of Umbilical Cord Mesenchymal Stem Cell Local Intramuscular Injection for Treatment of Uterine Scars Recruiting NCT03181087 Phase 1
11 Factors Associated With Complications of Cervical Necrotizing Fasciitis Unknown status NCT02847234
12 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
13 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
14 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
15 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
16 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
17 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Completed NCT01790698
18 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
19 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
20 Health-related Quality of Life After Massive Burn Injury Completed NCT03660150
21 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
22 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
23 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care
24 Evaluation of a New Device "Orthèse Diabète" in the Healing of Foot Ulcers in Diabetic Patients Completed NCT01956162 Not Applicable
25 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
26 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
27 Genetic Susceptibility to Severe Streptococcal Infections Active, not recruiting NCT01911572
28 Hyperglycemia in Surgical Infections Terminated NCT00353275 Not Applicable Strict Glycemic control;Conventional Glycemic Control
29 Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) Withdrawn NCT00896402 Not Applicable Skin antisepsis with chlorhexidine;povidone-iodine

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

42
Skin, Breast, Colon, Liver, Bone, Kidney, Bone Marrow

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 1787)
# Title Authors Year
1
Predisposing factors of necrotizing fasciitis with comparison to cellulitis in Taiwan: A nationwide population-based case-control study. ( 30738634 )
2019
2
A case report of successful treatment of necrotizing fasciitis using negative pressure wound therapy. ( 30633151 )
2019
3
Fitness genes of group A streptococci in necrotizing fasciitis and myositis. ( 30667379 )
2019
4
Necrotizing fasciitis with mediastinitis following snakebite envenomation. ( 30671248 )
2019
5
A Rare Presentation of Escherichia coli Necrotizing Fasciitis in Renal Transplantation. ( 30674239 )
2019
6
A Multiplex PCR assay for Detection of Vibrio vulnificus, Aeromonas hydrophila, Methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus agalactiae from the Isolates of Patients with Necrotizing Fasciitis. ( 30690211 )
2019
7
A case report of successful treatment of necrotizing fasciitis using negative pressure wound therapy: Erratum. ( 30702636 )
2019
8
Monomicrobial gram-negative necrotizing fasciitis: An uncommon but fatal syndrome. ( 30713116 )
2019
9
Fasciotomy wound secondary to necrotizing fasciitis closure using combination of negative pressure wound therapy and progressive primary closure. ( 30756498 )
2019
10
Ultrasonography for early detection of non-infectious necrotizing fasciitis secondary to cutaneous loxoscelism. ( 30768820 )
2019
11
Surgical management of a perforated caecal carcinoma presenting as abdominal wall necrotizing fasciitis. ( 30790418 )
2019
12
Necrotizing Fasciitis Following Herpes Zoster Ophthalmicus in an Immunocompromised Patient. ( 30805235 )
2019
13
Lactate on emergency department arrival as a predictor of in-hospital mortality in necrotizing fasciitis: a retrospective study. ( 30841912 )
2019
14
A Patient With Periorbital Necrotizing Fasciitis by Klebsiella pneumoniae. ( 30845085 )
2019
15
Internal Jugular Vein Thrombosis with Serious Cervical Necrotizing Fasciitis. ( 30865123 )
2019
16
Distinguishing necrotizing from non-necrotizing fasciitis: a new predictive scoring integrating MRI in the LRINEC score. ( 30887193 )
2019
17
Exhaustion of the immune system by Group A Streptococcus necrotizing fasciitis: the occurrence of late secondary infections in a retrospective study. ( 30899798 )
2019
18
Necrotizing Fasciitis Involving Spine: Unusual Medical Emergency for Spine Surgeon. ( 30321674 )
2019
19
A successful treatment of necrotizing fasciitis following the surgery of distal radius plate removal: A case report and literature review. ( 29642157 )
2018
20
Necrotizing fasciitis following abdominal gunshot wound. ( 29766139 )
2018
21
Necrotizing fasciitis after scrotum skin injury in an infant: A case report. ( 29561416 )
2018
22
Cervical necrotizing fasciitis: Systematic review and analysis of 1235 reported cases from the literature. ( 29934952 )
2018
23
Rapid progression and mortality of necrotizing fasciitis caused by Aeromonas hydrophila in a patient with type I open tibial fracture. ( 29699639 )
2018
24
Genomic insights of reduced teicoplanin susceptible community acquired methicillin resistant Staphylococcus aureus MRSA: Case of necrotizing fasciitis. ( 29775787 )
2018
25
Necrotizing fasciitis following minor skin surgery in a patient receiving treatment with infliximab and prednisolone. ( 29400281 )
2018
26
Monomicrobial Klebsiella pneumoniae necrotizing fasciitis: an emerging life-threatening entity. ( 29787886 )
2018
27
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
28
Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review. ( 29424798 )
2018
29
The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study. ( 29369913 )
2018
30
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases. ( 29629889 )
2018
31
Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model. ( 29684366 )
2018
32
Bicipital Tendinopathy and Carpal Valgus Following a Distant Direct Thoracoabdominal Skin Flap in a German Shepherd with Necrotizing Fasciitis. ( 29757663 )
2018
33
Periocular Necrotizing Fasciitis with Toxic Shock Syndrome. ( 29928226 )
2018
34
Cervicofacial Necrotizing Fasciitis and Drugs. ( 29916971 )
2018
35
A case of periorbital necrotizing fasciitis rapidly progressing to severe multiorgan failure. ( 29765591 )
2018
36
Two fatal cases of Aeromonas dhakensis bacteremia and necrotizing fasciitis in severe dengue patients. ( 29859782 )
2018
37
Necrotizing fasciitis after a watercraft accident. ( 29883311 )
2018
38
Bilateral periorbital necrotizing fasciitis: case report. ( 29924201 )
2018
39
Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis. ( 29099935 )
2018
40
Atypical Presentation of Escherichia coli Monomicrobial Necrotizing Fasciitis in a Renal Transplant Patient: A Case Report. ( 29588065 )
2018
41
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
42
Necrotizing fasciitis following spinal anesthesia: A rare and devastating complication. ( 29416475 )
2018
43
Necrotizing fasciitis: case series and review of the literature on clinical and medico-legal diagnostic challenges. ( 29627916 )
2018
44
Scrotal Reconstruction with Integra Following Necrotizing Fasciitis. ( 29628671 )
2018
45
Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. ( 29854478 )
2018
46
Necrotizing fasciitis of chest and right abdominal wall caused by acute perforated appendicitis: Case report. ( 30368121 )
2018
47
Community-acquired Disseminated Exophiala dermatitidis Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease. ( 30449799 )
2018
48
Necrotizing fasciitis following colonoscopy in the setting of ulcerative colitis. ( 30548148 )
2018
49
Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report. ( 30478748 )
2018
50
A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus. ( 30555141 )
2018

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCNF CD46 CXCL8 ICOSLG IL18 IL1RN
2
Show member pathways
13.15 CXCL8 IL18 IL1RN IL2 IL6 LTA
3
Show member pathways
13.1 CXCL8 IL18 IL2 IL6 LTA
4
Show member pathways
12.54 CXCL8 ICOSLG IL18 IL2 IL6 LTA
5
Show member pathways
12.22 CD46 CXCL8 IL18 IL2 IL6 LTA
6 12.01 CXCL8 IL1RN IL6
7
Show member pathways
11.98 CXCL8 IL18 IL1RN IL6
8
Show member pathways
11.98 CXCL8 IL18 IL2 IL6 LTA
9
Show member pathways
11.91 CXCL8 IL18 IL2 IL6
10 11.87 CXCL8 IL2 IL6
11 11.84 CXCL8 IL18 IL6
12
Show member pathways
11.82 IL18 IL2 IL6 LTA
13 11.74 CXCL8 IL18 IL2
14 11.72 CXCL8 IL18 IL6
15 11.69 CXCL8 IL18 IL6
16
Show member pathways
11.65 CXCL8 IL2 LTA
17 11.64 CXCL8 IL2 IL6
18 11.62 IL18 IL2 LTA
19
Show member pathways
11.5 CXCL8 IL2 IL6
20 11.39 CXCL8 IL18 IL6
21 11.32 CXCL8 IL18 IL6
22 11.31 IL18 IL1RN IL2 IL6
23 11.22 IL18 IL6
24 11.18 CXCL8 IL6
25 11.15 IL18 IL6
26 11.1 IL2 IL6
27 11.08 IL18 IL2
28 11.04 IL2 LTA
29 10.9 CXCL8 IL6
30 10.81 CXCL8 IL18 IL2 IL6 LTA
31 10.61 CXCL8 IL18 IL1RN IL6
32 10.58 CXCL8 IL18 IL2 IL6 LTA

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CXCL8 IL18 IL1RN IL6
2 cell-cell signaling GO:0007267 9.76 IL18 IL2 LTA
3 cellular response to lipopolysaccharide GO:0071222 9.74 CXCL8 IL1RN IL6
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IL18 IL2 IL6
5 natural killer cell activation GO:0030101 9.58 IL18 IL2
6 positive regulation of T cell proliferation GO:0042102 9.58 CD46 IL2 IL6
7 positive regulation of glial cell proliferation GO:0060252 9.56 IL6 LTA
8 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL18 IL1RN IL2 IL6
9 positive regulation of interleukin-17 production GO:0032740 9.54 IL18 IL2
10 positive regulation of immunoglobulin secretion GO:0051024 9.52 IL2 IL6
11 positive regulation of regulatory T cell differentiation GO:0045591 9.51 CD46 IL2
12 positive regulation of interferon-gamma production GO:0032729 9.5 IL18 IL2 LTA
13 neutrophil activation GO:0042119 9.49 CXCL8 IL18
14 positive regulation of neuroinflammatory response GO:0150078 9.46 IL18 IL6
15 positive regulation of tissue remodeling GO:0034105 9.43 IL18 IL2
16 positive regulation of activated T cell proliferation GO:0042104 9.43 ICOSLG IL18 IL2
17 immune response GO:0006955 9.43 CXCL8 IL18 IL1RN IL2 IL6 LTA
18 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.37 IL1RN IL6
19 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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