MCID: NCR003
MIFTS: 37

Necrotizing Sialometaplasia

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

MalaCards integrated aliases for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 15
Sialometaplasia, Necrotizing 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
ICD10 33 K11.8
MeSH 44 D012797
UMLS 73 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to squamous cell carcinoma and adenosquamous carcinoma. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways/superpathways are DNA Damage and Activation of BH3-only proteins. Affiliated tissues include salivary gland, t cells and lung, and related phenotypes are growth/size/body region and digestive/alimentary

Wikipedia : 76 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.3 CDKN2A MKI67 TP53 TP63
2 adenosquamous carcinoma 29.9 KIT KRT5 KRT7 TP53 TP63
3 warthin tumor 29.8 CRTC1 KIT KRT7 MAML2
4 adenoid cystic carcinoma 29.5 ACTC1 KIT KRT5 KRT7 MKI67 TP53
5 peritoneum cancer 10.3 KRT5 KRT7
6 malignant biphasic mesothelioma 10.3 KRT5 KRT7
7 gastric squamous cell carcinoma 10.3 KRT5 KRT7
8 breast squamous cell carcinoma 10.3 KRT5 TP53
9 papillary serous adenocarcinoma 10.3 KRT7 TP53
10 female reproductive endometrioid cancer 10.3 KRT7 TP53
11 pleomorphic carcinoma 10.3 KRT7 TP53
12 bowen's disease 10.3 KRT7 MKI67
13 balloon cell malignant melanoma 10.3 KRT5 KRT7
14 benign breast adenomyoepithelioma 10.3 KRT5 KRT7
15 benign mesothelioma 10.3 KRT5 KRT7
16 cystic basal cell carcinoma 10.3 KRT7 TP63
17 brain ependymoma 10.3 MKI67 TP53
18 vulvar intraepithelial neoplasia 10.3 KRT7 TP53
19 sensory organ benign neoplasm 10.2 KRT5 KRT7
20 medulloepithelioma 10.2 GFAP KRT7
21 glioma susceptibility 1 10.2 GFAP TP53
22 benign glioma 10.2 GFAP TP53
23 bile duct mucoepidermoid carcinoma 10.2 KRT5 KRT7
24 cerebral ventricle cancer 10.2 GFAP TP53
25 chordoid glioma 10.2 GFAP TP53
26 ependymoblastoma 10.2 GFAP TP53
27 malignant ependymoma 10.2 GFAP TP53
28 middle ear adenoma 10.2 KRT5 KRT7
29 malignant giant cell tumor 10.2 ACTC1 TP53
30 fibrillary astrocytoma 10.2 GFAP TP53
31 angiocentric glioma 10.2 ACTC1 GFAP
32 syringoma 10.2 GFAP TP63
33 epidural neoplasm 10.2 CD5 KRT5
34 large cell acanthoma 10.2 KRT5 KRT7
35 bladder lymphoma 10.2 CD5 KRT7
36 thymus adenocarcinoma 10.2 CD5 KRT7
37 natural killer cell leukemia 10.2 GZMB TIA1
38 malignant spiradenoma 10.2 KRT5 KRT7 TP53
39 lymphomatoid papulosis 10.2 GZMB TIA1
40 hidradenoma 10.2 KRT7 MAML2
41 cll/sll 10.2 CD5 TP53
42 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
43 b cell prolymphocytic leukemia 10.2 CD5 TP53
44 lichen sclerosus 10.2 GZMB TP53
45 frontal convexity meningioma 10.2 GFAP TP53
46 prostate squamous cell carcinoma 10.2 KRT5 KRT7 TP53
47 eccrine sweat gland neoplasm 10.2 KRT5 KRT7 TP53
48 gliofibroma 10.2 GFAP TP53
49 apocrine sweat gland neoplasm 10.2 KRT5 KRT7
50 pleomorphic adenoma carcinoma 10.2 MAML2 TP53

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 ACTC1 CDKN2A CRTC1 GFAP KIT KRT5
2 digestive/alimentary MP:0005381 9.8 CDKN2A GFAP KIT KRT5 TP53 TP63
3 muscle MP:0005369 9.63 ACTC1 CDKN2A GFAP KIT TP53 TP63
4 no phenotypic analysis MP:0003012 9.5 CD5 CDKN2A KIT KRT5 MKI67 TP53
5 normal MP:0002873 9.17 ACTC1 CD5 GFAP KIT MKI67 TP53

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

41
Salivary Gland, T Cells, Lung, Ovary, Prostate, B Cells, Thymus

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 164)
# Title Authors Year
1
Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis. ( 28330578 )
2017
2
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. ( 27166051 )
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. ( 26634609 )
2016
4
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. ( 27833767 )
2016
5
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. ( 25564889 )
2015
6
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. ( 26734562 )
2015
7
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. ( 26816899 )
2015
8
Review of the literature on necrotizing sialometaplasia and case presentation. ( 25191669 )
2015
9
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. ( 26504909 )
2015
10
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. ( 26441480 )
2015
11
Surgical management of necrotizing sialometaplasia of palate. ( 26672431 )
2015
12
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. ( 25531850 )
2014
13
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. ( 24634907 )
2014
14
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. ( 24667056 )
2014
15
Necrotizing sialometaplasia: a diagnostic dilemma. ( 25284537 )
2014
16
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. ( 24850145 )
2014
17
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. ( 24820724 )
2014
18
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. ( 24863247 )
2014
19
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. ( 24837912 )
2014
20
Early references to necrotizing sialometaplasia. ( 24439923 )
2014
21
Necrotizing sialometaplasia: A diagnostic dilemma! ( 25948999 )
2014
22
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. ( 24353777 )
2013
23
Mandibular fracture and necrotizing sialometaplasia in a rabbit. ( 23561940 )
2013
24
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. ( 24217688 )
2013
25
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. ( 23375898 )
2013
26
A case of necrotizing sialometaplasia involving bilateral parotid glands. ( 23159016 )
2013
27
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. ( 23837804 )
2013
28
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. ( 23930450 )
2013
29
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. ( 22921832 )
2012
30
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. ( 22200659 )
2012
31
CT findings of necrotizing sialometaplasia. ( 22074871 )
2012
32
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. ( 22197541 )
2012
33
Necrotizing sialometaplasia of palate: a case report. ( 22957289 )
2012
34
Case report of necrotizing sialometaplasia. ( 21217621 )
2011
35
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. ( 21861916 )
2011
36
Necrotizing sialometaplasia of palate: a case report. ( 21977472 )
2011
37
Necrotizing sialometaplasia of the parotid gland in a dog. ( 21088187 )
2010
38
Necrotizing sialometaplasia-a practical approach to the diagnosis. ( 20073597 )
2010
39
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. ( 20842082 )
2010
40
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. ( 20403036 )
2010
41
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. ( 20618783 )
2010
42
Necrotizing sialometaplasia of bronchial mucosa. ( 19948640 )
2010
43
Necrotizing sialometaplasia of tongue. ( 21886996 )
2009
44
Bilateral localization of necrotizing sialometaplasia: a case report. ( 20184708 )
2009
45
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. ( 19434292 )
2009
46
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. ( 19118785 )
2009
47
Necrotizing sialometaplasia: a practical approach to the diagnosis. ( 19415943 )
2009
48
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. ( 19482450 )
2009
49
Case of the month. Necrotizing sialometaplasia. ( 18567189 )
2008
50
Case report. MRI findings of necrotizing sialometaplasia. ( 18487385 )
2008

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

GO Terms for Necrotizing Sialometaplasia

Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 ACTC1 CDKN2A CRTC1 GFAP GZMB KIT
2 cytosol GO:0005829 9.32 ACTC1 CDKN2A CRTC1 GFAP GZMB KRT5

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.77 CDKN2A GZMB TIA1 TP53 TP63
2 positive regulation of gene expression GO:0010628 9.76 ACTC1 CDKN2A KIT TP53
3 cell proliferation GO:0008283 9.71 CD5 MKI67 TP53 TP63
4 entrainment of circadian clock by photoperiod GO:0043153 9.43 CRTC1 TP53
5 protein homotetramerization GO:0051289 9.33 CRTC1 TP53 TP63
6 replicative senescence GO:0090399 9.32 CDKN2A TP53
7 somatic stem cell division GO:0048103 9.26 CDKN2A KIT
8 positive regulation of Notch signaling pathway GO:0045747 9.13 KIT MAML2 TP63
9 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.8 GZMB TP53 TP63

Sources for Necrotizing Sialometaplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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49 NCI
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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