MCID: NCR003
MIFTS: 36

Necrotizing Sialometaplasia

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

MalaCards integrated aliases for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 15
Sialometaplasia, Necrotizing 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
ICD10 33 K11.8
MeSH 44 D012797
SNOMED-CT 68 109769000
UMLS 73 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to adenosquamous carcinoma and warthin tumor. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways/superpathways are DNA Damage and Activation of BH3-only proteins. Affiliated tissues include salivary gland, trachea and tongue, and related phenotypes are growth/size/body region and digestive/alimentary

Wikipedia : 76 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 30.4 KRT5 KRT7 TP53 TP63
2 warthin tumor 29.6 CRTC1 KIT MAML2
3 squamous cell carcinoma 29.5 CDKN2A MKI67 TP53 TP63
4 adenoid cystic carcinoma 28.6 ACTC1 KIT KRT7 MKI67 TP53 TP63
5 balloon cell malignant melanoma 11.0 KRT5 KRT7
6 benign breast adenomyoepithelioma 11.0 KRT5 KRT7
7 sensory organ benign neoplasm 11.0 KRT5 KRT7
8 bile duct mucoepidermoid carcinoma 10.9 KRT5 KRT7
9 middle ear adenoma 10.9 KRT5 KRT7
10 vulvar intraepithelial neoplasia 10.9 KRT5 TP53
11 large cell acanthoma 10.9 KRT5 KRT7
12 cystic basal cell carcinoma 10.9 KRT7 TP63
13 papillary adenoma 10.9 KRT5 KRT7
14 female reproductive endometrioid cancer 10.9 KRT7 TP53
15 apocrine sweat gland neoplasm 10.9 KRT5 KRT7
16 eccrine sweat gland neoplasm 10.9 KRT7 TP53
17 apocrine adenocarcinoma 10.9 KRT5 KRT7
18 brain ependymoma 10.9 MKI67 TP53
19 malignant giant cell tumor 10.9 ACTC1 TP53
20 benign metastasizing leiomyoma 10.8 ACTC1 KRT7
21 papillary serous adenocarcinoma 10.8 KRT7 TP53
22 spiradenoma 10.8 KRT7 TP53
23 bowen's disease 10.8 KRT7 MKI67
24 breast squamous cell carcinoma 10.7 KRT5 TP53
25 frontal convexity meningioma 10.7 GFAP TP53
26 gliofibroma 10.7 GFAP TP53
27 malignant spiradenoma 10.7 KRT5 KRT7 TP53
28 prostate squamous cell carcinoma 10.7 KRT5 KRT7 TP53
29 cerebral convexity meningioma 10.7 GFAP TP53
30 protoplasmic astrocytoma 10.7 GFAP TP53
31 sweat gland cancer 10.7 KRT5 KRT7 TP53
32 cellular ependymoma 10.7 GFAP TP53
33 anaplastic ganglioglioma 10.7 ACTC1 GFAP
34 large cell carcinoma 10.7 KRT5 KRT7 TP63
35 central nervous system primitive neuroectodermal neoplasm 10.6 GFAP TP53
36 cutaneous leiomyosarcoma 10.6 ACTC1 GFAP
37 orbit lymphoma 10.6 GZMB TIA1
38 lichen sclerosus et atrophicus 10.6 GZMB TIA1
39 lymphomatoid granulomatosis 10.6 GZMB TIA1
40 cerebral neuroblastoma 10.6 GFAP TP53
41 granulosa cell tumor of the ovary 10.6 ACTC1 KRT7 TP53
42 mixed glioma 10.6 GFAP TP53
43 spinal cancer 10.6 GFAP TP53
44 viral esophagitis 10.6 GZMB TIA1
45 lichen sclerosus 10.6 GZMB TP53
46 syringocystadenoma papilliferum 10.6 ACTC1 GFAP
47 ependymoblastoma 10.6 GFAP TP53
48 lymphocytic gastritis 10.6 GZMB TIA1
49 subcutaneous panniculitis-like t-cell lymphoma 10.6 GZMB TIA1
50 primary cutaneous anaplastic large cell lymphoma 10.6 GZMB TIA1

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 TP63 ACTC1 CDKN2A CRTC1 GFAP KIT
2 digestive/alimentary MP:0005381 9.73 TP63 CDKN2A GFAP KIT KRT5 TP53
3 no phenotypic analysis MP:0003012 9.5 CD5 CDKN2A KIT KRT5 MKI67 TP53
4 normal MP:0002873 9.17 ACTC1 CD5 GFAP KIT MKI67 TP53

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

41
Salivary Gland, Trachea, Tongue, T Cells, Testes

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 162)
# Title Authors Year
1
Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis. ( 28330578 )
2017
2
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. ( 27166051 )
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. ( 26634609 )
2016
4
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. ( 27833767 )
2016
5
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. ( 25564889 )
2015
6
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. ( 26734562 )
2015
7
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. ( 26816899 )
2015
8
Review of the literature on necrotizing sialometaplasia and case presentation. ( 25191669 )
2015
9
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. ( 26504909 )
2015
10
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. ( 26441480 )
2015
11
Surgical management of necrotizing sialometaplasia of palate. ( 26672431 )
2015
12
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. ( 25531850 )
2014
13
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. ( 24634907 )
2014
14
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. ( 24667056 )
2014
15
Necrotizing sialometaplasia: a diagnostic dilemma. ( 25284537 )
2014
16
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. ( 24850145 )
2014
17
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. ( 24820724 )
2014
18
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. ( 24863247 )
2014
19
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. ( 24837912 )
2014
20
Necrotizing sialometaplasia: A diagnostic dilemma! ( 25948999 )
2014
21
Early references to necrotizing sialometaplasia. ( 24439923 )
2014
22
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. ( 24353777 )
2013
23
Mandibular fracture and necrotizing sialometaplasia in a rabbit. ( 23561940 )
2013
24
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. ( 24217688 )
2013
25
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. ( 23375898 )
2013
26
A case of necrotizing sialometaplasia involving bilateral parotid glands. ( 23159016 )
2013
27
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. ( 23837804 )
2013
28
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. ( 23930450 )
2013
29
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. ( 22921832 )
2012
30
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. ( 22200659 )
2012
31
CT findings of necrotizing sialometaplasia. ( 22074871 )
2012
32
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. ( 22197541 )
2012
33
Necrotizing sialometaplasia of palate: a case report. ( 22957289 )
2012
34
Case report of necrotizing sialometaplasia. ( 21217621 )
2011
35
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. ( 21861916 )
2011
36
Necrotizing sialometaplasia of palate: a case report. ( 21977472 )
2011
37
Necrotizing sialometaplasia of the parotid gland in a dog. ( 21088187 )
2010
38
Necrotizing sialometaplasia-a practical approach to the diagnosis. ( 20073597 )
2010
39
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. ( 20842082 )
2010
40
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. ( 20403036 )
2010
41
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. ( 20618783 )
2010
42
Necrotizing sialometaplasia of bronchial mucosa. ( 19948640 )
2010
43
Necrotizing sialometaplasia of tongue. ( 21886996 )
2009
44
Bilateral localization of necrotizing sialometaplasia: a case report. ( 20184708 )
2009
45
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. ( 19434292 )
2009
46
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. ( 19118785 )
2009
47
Necrotizing sialometaplasia: a practical approach to the diagnosis. ( 19415943 )
2009
48
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. ( 19482450 )
2009
49
Case of the month. Necrotizing sialometaplasia. ( 18567189 )
2008
50
Case report. MRI findings of necrotizing sialometaplasia. ( 18487385 )
2008

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

GO Terms for Necrotizing Sialometaplasia

Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.32 ACTC1 CDKN2A CRTC1 GFAP GZMB KRT5

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.8 CDKN2A GZMB TIA1 TP53 TP63
2 positive regulation of gene expression GO:0010628 9.78 ACTC1 CDKN2A KIT TP53
3 cell proliferation GO:0008283 9.76 CD5 MKI67 TP53 TP63
4 response to X-ray GO:0010165 9.51 TP53 TP63
5 entrainment of circadian clock by photoperiod GO:0043153 9.49 CRTC1 TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 TP53 TP63
7 replicative senescence GO:0090399 9.37 CDKN2A TP53
8 protein homotetramerization GO:0051289 9.33 CRTC1 TP53 TP63
9 somatic stem cell division GO:0048103 9.32 CDKN2A KIT
10 mitotic G1 DNA damage checkpoint GO:0031571 9.26 TP53 TP63
11 positive regulation of Notch signaling pathway GO:0045747 9.13 KIT MAML2 TP63
12 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.8 GZMB TP53 TP63

Sources for Necrotizing Sialometaplasia

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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44 MeSH
45 MESH via Orphanet
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49 NCI
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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