MCID: NCR003
MIFTS: 29

Necrotizing Sialometaplasia

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

MalaCards integrated aliases for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 15 17
Sialometaplasia, Necrotizing 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
MeSH 44 D012797
SNOMED-CT 67 109769000
ICD10 32 K11.8
UMLS 70 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to salivary gland disease and in situ carcinoma. An important gene associated with Necrotizing Sialometaplasia is KRT7 (Keratin 7), and among its related pathways/superpathways are Cytoskeletal Signaling and DNA Damage. Affiliated tissues include breast, salivary gland and lung.

Wikipedia : 73 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 salivary gland disease 30.1 TP53 KRT7 KRT5
2 in situ carcinoma 29.9 TP53 KRT5
3 mucoepidermoid carcinoma 29.8 TP63 TP53 MKI67 KRT7 KRT5
4 epithelial-myoepithelial carcinoma 29.7 TP53 KRT7 ACTC1
5 myoepithelial carcinoma 29.7 TP53 KRT7 ACTC1
6 barrett esophagus 29.6 TP53 MKI67 KRT7
7 pleomorphic adenoma 29.6 TP63 TP53 KRT7 ACTC1
8 breast fibroadenoma 29.5 TP63 TP53 MKI67
9 adenosquamous carcinoma 29.5 TP63 TP53 KRT7 KRT5
10 adenoid cystic carcinoma 29.4 TP63 TP53 KRT7 KRT5 ACTC1
11 squamous cell carcinoma 29.4 TP63 TP53 MKI67 KRT7
12 basal cell carcinoma 29.0 TP63 TP53 MKI67 KRT7 KRT5
13 breast ductal carcinoma 28.8 TP63 TP53 MKI67 KRT7 KRT5
14 eating disorder 10.3
15 dysphagia 10.2
16 ureter squamous cell carcinoma 10.2 KRT7 KRT5
17 inverted transitional papilloma 10.2 KRT7 KRT5
18 ceruminoma 10.2 KRT7 KRT5
19 ureter adenocarcinoma 10.2 KRT7 KRT5
20 subareolar duct papillomatosis 10.2 KRT7 KRT5
21 malignant acrospiroma 10.2 KRT7 KRT5
22 nipple benign neoplasm 10.2 KRT7 KRT5
23 auditory system benign neoplasm 10.2 KRT7 KRT5
24 microinvasive cervical squamous cell carcinoma 10.2 KRT7 KRT5
25 ceruminous adenocarcinoma 10.2 KRT7 KRT5
26 cutaneous mucoepidermoid carcinoma 10.2 KRT7 KRT5
27 external ear carcinoma 10.2 KRT7 KRT5
28 benign breast adenomyoepithelioma 10.2 KRT7 KRT5
29 eccrine adenocarcinoma 10.2 KRT7 KRT5
30 lung clear cell carcinoma 10.2 KRT7 KRT5
31 vulvar apocrine adenocarcinoma 10.2 KRT7 KRT5
32 apocrine adenocarcinoma 10.2 KRT7 KRT5
33 papillary squamous carcinoma 10.2 KRT7 KRT5
34 sensory organ benign neoplasm 10.2 KRT7 KRT5
35 malignant syringoma 10.2 KRT7 KRT5
36 gastric squamous cell carcinoma 10.2 KRT7 KRT5
37 bile duct mucoepidermoid carcinoma 10.2 KRT7 KRT5
38 squamous cell bile duct carcinoma 10.2 KRT7 KRT5
39 middle ear adenocarcinoma 10.2 KRT7 KRT5
40 breast metaplastic carcinoma 10.2 KRT7 KRT5
41 breast mucinous carcinoma 10.2 KRT7 KRT5
42 pericardium cancer 10.2 KRT7 KRT5
43 balloon cell malignant melanoma 10.2 KRT7 KRT5
44 clear cell hidradenoma 10.2 KRT7 KRT5
45 hidradenoma 10.2 KRT7 KRT5
46 nephrogenic adenoma of the urethra 10.2 KRT7 KRT5
47 eccrine papillary adenocarcinoma 10.2 KRT7 KRT5
48 eccrine acrospiroma 10.2 KRT7 KRT5
49 trachea carcinoma 10.2 KRT7 KRT5
50 mucinous stomach adenocarcinoma 10.2 KRT7 KRT5

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

40
Breast, Salivary Gland, Lung, Thymus, Tongue, Trachea, Kidney

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 256)
# Title Authors PMID Year
1
Necrotizing sialometaplasia of the tonsillar pillar. An unusual case. 61
33575007 2021
2
Necrotizing sialometaplasia: a case report of a non-ulcerated histopathological presentation. 61
33423426 2020
3
A case of necrotizing sialometaplasia. 61
31582173 2020
4
Necrotizing sialometaplasia - Case report. 61
32952899 2020
5
Necrotizing sialometaplasia: a malignant masquerade but questionable precancerous lesion, report of four cases. 61
32664899 2020
6
A retrospective study of salivary gland diseases in 179 dogs (2010-2018). 61
32687011 2020
7
Necrotizing Sialometaplasia and Bulimia: A Case Report. 61
32325833 2020
8
[Immunohistochemical diagnosis of necrotizing sialometaplasia]. 61
33034184 2020
9
Necrotizing sialometaplasia of the palate in a young bodybuilder with anabolic androgenic steroids abuse. 61
32080687 2020
10
Low-Level Laser Therapy Approach of Bilateral Necrotizing Sialometaplasia of the Hard and Soft Palates. 61
32802297 2020
11
Necrotizing Sialometaplasia of the Hypopharynx. 61
30966809 2019
12
Soft Palate Subacute Necrotising Sialadenitis: A Case Report. 61
31741964 2019
13
Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series. 61
30776173 2019
14
Imaging of Minor Salivary Glands. 61
29622120 2018
15
Unusual Presentation of Castleman Disease in the Oral Cavity. 61
28468192 2017
16
Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis. 61
28330578 2017
17
Morphological and Histological Effects of Radiofrequency and Laser (KTP and Nd:YAG) Treatment of the Inferior Turbinates in Animals. 61
27733711 2017
18
Histological reclassification of parotid gland carcinomas: importance for clinicians. 61
27101824 2016
19
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. 61
27166051 2016
20
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. 61
26504909 2016
21
[Aphthous ulcers and oral ulcerations]. 61
26880080 2016
22
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. 61
27833767 2016
23
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. 61
26634609 2016
24
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. 61
26734562 2015
25
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. 61
26816899 2015
26
Surgical management of necrotizing sialometaplasia of palate. 61
26672431 2015
27
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. 61
26441480 2015
28
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. 61
25564889 2015
29
Review of the literature on necrotizing sialometaplasia and case presentation. 61
25191669 2015
30
An unusual presentation of NK/T-cell lymphoma, nasal-type in the United States. 61
25304998 2015
31
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. 61
25531850 2014
32
Necrotizing sialometaplasia: a diagnostic dilemma. 61
25284537 2014
33
Necrotizing sialometaplasia: A diagnostic dilemma! 61
25948999 2014
34
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. 61
24863247 2014
35
HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. 61
23837804 2014
36
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. 61
24837912 2014
37
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. 61
24820724 2014
38
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. 61
24667056 2014
39
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. 61
24634907 2014
40
Early references to necrotizing sialometaplasia. 61
24439923 2014
41
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. 61
24850145 2014
42
[Necrotizing sialometaplasia--diagnostic difficulties--literature review]. 61
25248245 2014
43
[Necrotizing sialometaplasia]. 61
24881145 2014
44
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. 61
24217688 2013
45
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. 61
23375898 2013
46
A case of necrotizing sialometaplasia involving bilateral parotid glands. 61
23159016 2013
47
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. 61
23930450 2013
48
Mandibular fracture and necrotizing sialometaplasia in a rabbit. 61
23561940 2013
49
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. 61
24353777 2013
50
[A woman with an abnormality of the palate]. 61
23965242 2013

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

Pathways related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.82 KRT7 KRT5 ACTC1
2 11.6 TP63 TP53 MKI67
3
Show member pathways
9.97 TP63 TP53

GO Terms for Necrotizing Sialometaplasia

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron apoptotic process GO:0051402 9.32 TP63 TP53
2 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.26 TP63 TP53
3 cell aging GO:0007569 9.16 TP63 TP53
4 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.96 TP63 TP53
5 protein tetramerization GO:0051262 8.62 TP63 TP53

Molecular functions related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 8.96 TP63 TP53
2 MDM2/MDM4 family protein binding GO:0097371 8.62 TP63 TP53

Sources for Necrotizing Sialometaplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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