NSTI
MCID: NCR014
MIFTS: 24

Necrotizing Soft Tissue Infection (NSTI)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Necrotizing Soft Tissue Infection

MalaCards integrated aliases for Necrotizing Soft Tissue Infection:

Name: Necrotizing Soft Tissue Infection 58
Nsti 58

Characteristics:

Orphanet epidemiological data:

58
necrotizing soft tissue infection
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 M72.6
Orphanet 58 ORPHA440368

Summaries for Necrotizing Soft Tissue Infection

MalaCards based summary : Necrotizing Soft Tissue Infection, also known as nsti, is related to fasciitis and toxic shock syndrome. An important gene associated with Necrotizing Soft Tissue Infection is FCN2 (Ficolin 2). The drugs Immunologic Factors and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include colon, spinal cord and skin.

Related Diseases for Necrotizing Soft Tissue Infection

Diseases related to Necrotizing Soft Tissue Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 fasciitis 10.7
2 toxic shock syndrome 10.7
3 necrotizing fasciitis 10.7
4 cellulitis 10.5
5 myositis 10.4
6 gas gangrene 10.3
7 streptococcal toxic-shock syndrome 10.3
8 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.3
9 fournier gangrene 10.3
10 osteomyelitis 10.2
11 neutropenia 10.2
12 diverticulitis 10.2
13 mucormycosis 10.2
14 vasculitis 10.2
15 decubitus ulcer 10.2
16 spinal cord injury 10.2
17 colorectal cancer 10.0
18 esophageal cancer 10.0
19 cyclic neutropenia 10.0
20 type 1 diabetes mellitus 10.0
21 myeloma, multiple 10.0
22 body mass index quantitative trait locus 11 10.0
23 gallbladder disease 1 10.0
24 body mass index quantitative trait locus 9 10.0
25 body mass index quantitative trait locus 8 10.0
26 pulmonary disease, chronic obstructive 10.0
27 body mass index quantitative trait locus 4 10.0
28 body mass index quantitative trait locus 10 10.0
29 neutrophilic dermatosis, acute febrile 10.0
30 body mass index quantitative trait locus 7 10.0
31 diabetes mellitus, ketosis-prone 10.0
32 fontaine progeroid syndrome 10.0
33 body mass index quantitative trait locus 12 10.0
34 body mass index quantitative trait locus 14 10.0
35 leukemia, acute lymphoblastic 10.0
36 body mass index quantitative trait locus 18 10.0
37 body mass index quantitative trait locus 19 10.0
38 disease by infectious agent 10.0
39 inflammatory bowel disease 10.0
40 metabolic acidosis 10.0
41 inguinal hernia 10.0
42 urinary tract infection 10.0
43 portal vein thrombosis 10.0
44 cryptococcosis 10.0
45 paronychia 10.0
46 panniculitis 10.0
47 alcohol use disorder 10.0
48 squamous cell carcinoma 10.0
49 dysostosis 10.0
50 intestinal perforation 10.0

Graphical network of the top 20 diseases related to Necrotizing Soft Tissue Infection:



Diseases related to Necrotizing Soft Tissue Infection

Symptoms & Phenotypes for Necrotizing Soft Tissue Infection

Drugs & Therapeutics for Necrotizing Soft Tissue Infection

Drugs for Necrotizing Soft Tissue Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Immunoglobulin G Phase 2
3 Immunoglobulins Phase 2
4 Rho(D) Immune Globulin Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 gamma-Globulins Phase 2
7 Antibodies Phase 2
8
Glycerol Approved, Investigational 56-81-5 753
9
Protein C Approved
10 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study of AB103 as Compared to Placebo in Patients With Necrotizing Soft Tissue Infections. ACCUTE (AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections) Completed NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Evaluation of Safety, Pharmacokinetics and Immunomodulatory Effects of AB103, a CD28 Co-stimulatory Receptor Antagonist, in Patients Diagnosed With Necrotizing Soft Tissue Infections Completed NCT01417780 Phase 2 AB103 0.25 mg/kg;AB103 0.5 mg/kg;NaCl 0.9%
4 Comparative Study of Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed Preparation in Necrotising Soft Tissue Infections Unknown status NCT02314468
5 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
6 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
7 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
8 RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections Completed NCT02025816
9 Demographic Characteristics, Symptoms, Treatment and Mortality of Patients With Necrotizing Soft Tissue Infections Recruiting NCT04801615

Search NIH Clinical Center for Necrotizing Soft Tissue Infection

Genetic Tests for Necrotizing Soft Tissue Infection

Anatomical Context for Necrotizing Soft Tissue Infection

MalaCards organs/tissues related to Necrotizing Soft Tissue Infection:

40
Colon, Spinal Cord, Skin, Appendix, Kidney, Liver

Publications for Necrotizing Soft Tissue Infection

Articles related to Necrotizing Soft Tissue Infection:

(show top 50) (show all 477)
# Title Authors PMID Year
1
Current management of necrotizing soft-tissue infections. 61
33278180 2021
2
Adjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: A systematic review and meta-analysis. 61
33761539 2021
3
Group B streptococcal necrotizing soft-tissue infection: role of pharyngeal and perineal carriage. 61
32931041 2021
4
Factors Associated with Mortality Following Burns Complicated by Necrotizing Skin and Soft Tissue Infections: A Systematic Review and Meta-analysis of Individual Participant Data. 61
33682000 2021
5
Rapidly fatal tropical pyomyositis in an elderly diabetic woman. 61
33540127 2021
6
Obesity Is Not an Independent Predictor of Necrotizing Soft Tissue Infection Outcomes. 61
32320347 2021
7
Abdominal Extension of Fournier Gangrene From Undiagnosed Crohn's Disease: A Case Report. 61
33742649 2021
8
Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft-tissue infection. 61
33719215 2021
9
Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection. 61
33444122 2021
10
The Burden of Readmission After Discharge From Necrotizing Soft Tissue Infection. 61
33755642 2021
11
Resolution of Organ Dysfunction as a Predictor of Long-Term Survival in Necrotizing Soft Tissue Infections: Analysis of the ACCUTE Trial and a Retrospective Claims-Linked Database Study. 61
33797490 2021
12
Cervical Necrotizing Fasciitis, Diagnosis and Treatment of a Rare Life-Threatening Infection. 61
33570428 2021
13
Gap of knowledge in diagnosis of pyoderma gangrenosum in clinical specialties education. 61
33645932 2021
14
Streptococcus pyogenes necrotizing soft tissue infection following glucose monitoring with FreeStyle Libre device. 61
32277817 2021
15
Pyoderma gangrenosum underrepresentation in non-dermatological literature. 61
31913849 2021
16
Utility of the Laboratory Risk Indicator for Necrotizing Fasciitis Score: Comorbid Conditions Do Matter. 61
33544051 2021
17
Evaluation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for detecting necrotizing soft tissue infections in patients with diabetes and lower extremity infection. 61
33096188 2021
18
Getting it Right the First Time: Frozen Sections for Diagnosing Necrotizing Soft Tissue Infections. 61
32995933 2021
19
Analyzing Outcomes Among Older Adults With Necrotizing Soft-Tissue Infections in the United States. 61
32818779 2021
20
Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic. 61
33514404 2021
21
Squamous cell carcinoma arising from an ischial pressure ulcer initially suspected to be necrotizing soft tissue infection: A case report. 61
33461827 2021
22
Abdominoperineal Resection with Absorbable Mesh Repair of Perineal Defect for Fournier's Gangrene: A Case Report. 61
33664599 2021
23
Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study. 61
31923305 2021
24
Factors associated with mortality among patients with necrotizing soft tissue infections: An analysis of 4597 cases using the Diagnosis Procedure Combination Database. 61
33065296 2021
25
Health-related quality of life in necrotising soft tissue infection survivors: perspective from an Australian tertiary referral centre. 61
33438334 2021
26
[Necrotising soft-tissue infections]. 61
33491620 2021
27
Fulminant Necrotizing Soft-tissue Infection in an Extremely Low Gestational Age Infant. 61
33480664 2021
28
Antifungal Therapy in Fungal Necrotizing Soft Tissue Infections. 61
32711174 2020
29
Upper extremity necrotizing soft tissue infection: a complication of intravenous methamphetamine use. 61
33320421 2020
30
A case of a superficial circumflex iliac perforator-intercostal artery perforator (SCIP-ICAP) compound flap for necrotizing soft tissue infection. 61
33363848 2020
31
Chemotactic invasion in deep soft tissue by Vibrio vulnificus is essential for the progression of necrotic lesions. 61
32543985 2020
32
Clostridial Gas Gangrene - A Rare but Deadly Infection: Case series and Comparison to Other Necrotizing Soft Tissue Infections. 61
33015993 2020
33
Spontaneous Necrotizing Fasciitis. 61
33415033 2020
34
Necrotizing Soft Tissue Infection: Time is Crucial, and the Admitting Service Matters. 61
32240059 2020
35
Scrotal emphysema with characteristics of Fournier's gangrene in a community setting. 61
33102046 2020
36
Outcomes of β-Hemolytic Streptococcal Necrotizing Skin and Soft-tissue Infections and the Impact of Clindamycin Resistance. 61
33151283 2020
37
Retiform Purpura as a Sign of Necrotizing Cellulitis in an Immunocompetent Boy. 61
32970024 2020
38
Non-necrotizing and necrotizing soft tissue infections in South America: A retrospective cohort study. 61
32983444 2020
39
Pediatric necrotizing soft tissue infection after elective surgery: A case report and literature review. 61
32705989 2020
40
Rapidly fatal necrotizing soft tissue infection due to Clostridium sordellii in an injection drug user. 61
33189511 2020
41
Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study. 61
33067303 2020
42
Limitations of a Rapid Antigen Detection Test in the Early Diagnosis of Group A Streptococcal Necrotizing Soft Tissue Infection. 61
33133959 2020
43
Necrotizing Soft Tissue Infection of the Retroperitoneum From a Rectal Abscess. 61
32902329 2020
44
Necrotizing soft tissue infection of the perineum with intra-abdominal extension: presentation of two cases and literature review. 61
31898854 2020
45
Necrotizing Soft Tissue Infection After Intravenous Drug Injection: A Multidisciplinary Approach to Surgical Management at a Community Hospital. 61
32683915 2020
46
Leclercia adecarboxylata causing necrotising soft tissue infection in an immunocompetent adult. 61
32994267 2020
47
Management of carbapenem-resistant Klebsiella pneumoniae infection in a patient with diabetic foot ulcer and necrotizing soft tissue infection, bacteremia and lung infection: A case report. 61
32527579 2020
48
Updating the Burn Center Referral Criteria: Results From the 2018 eDelphi Consensus Study. 61
32123911 2020
49
Stage IV colorectal cancer presenting after necrotizing soft tissue infection. 61
33456176 2020
50
Necrotizing soft tissue infection of the upper extremities in patients with diabetes mellitus in a tertiary care center-a retrospective study. 61
32650278 2020

Variations for Necrotizing Soft Tissue Infection

Expression for Necrotizing Soft Tissue Infection

Search GEO for disease gene expression data for Necrotizing Soft Tissue Infection.

Pathways for Necrotizing Soft Tissue Infection

GO Terms for Necrotizing Soft Tissue Infection

Sources for Necrotizing Soft Tissue Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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