MCID: NCR014
MIFTS: 23

Necrotizing Soft Tissue Infection

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Necrotizing Soft Tissue Infection

MalaCards integrated aliases for Necrotizing Soft Tissue Infection:

Name: Necrotizing Soft Tissue Infection 59
Nsti 59

Characteristics:

Orphanet epidemiological data:

59
necrotizing soft tissue infection
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA440368
ICD10 via Orphanet 34 M72.6

Summaries for Necrotizing Soft Tissue Infection

MalaCards based summary : Necrotizing Soft Tissue Infection, also known as nsti, is related to acute pancreatitis and pancreatitis. An important gene associated with Necrotizing Soft Tissue Infection is FCN2 (Ficolin 2). The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, appendix and liver.

Related Diseases for Necrotizing Soft Tissue Infection

Diseases related to Necrotizing Soft Tissue Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 9.8
2 pancreatitis 9.8
3 decubitus ulcer 9.8
4 epiglottitis 9.8
5 fasciitis 9.8
6 candida glabrata 9.8
7 cyclic neutropenia 9.8
8 mycobacterium marinum 9.8
9 neutrophilic dermatosis, acute febrile 9.8
10 streptococcal toxic-shock syndrome 9.8
11 fontaine progeroid syndrome 9.8
12 burns 9.8
13 neutropenia 9.8
14 spinal cord injury 9.8
15 osteomyelitis 9.8
16 paronychia 9.8
17 toxic shock syndrome 9.8
18 ascending colon cancer 9.8

Graphical network of the top 20 diseases related to Necrotizing Soft Tissue Infection:



Diseases related to Necrotizing Soft Tissue Infection

Symptoms & Phenotypes for Necrotizing Soft Tissue Infection

Drugs & Therapeutics for Necrotizing Soft Tissue Infection

Drugs for Necrotizing Soft Tissue Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulin G Phase 2
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Immunoglobulins, Intravenous Phase 2
7
Glycerol Approved, Investigational Not Applicable 56-81-5 753
8
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
9
Protein C Approved
10 Protective Agents Not Applicable
11 Anti-Bacterial Agents Not Applicable
12 Anti-Infective Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Evaluation of Safety, PK and Immunomodulatory Effects of AB103 in Necrotizing Soft Tissue Infections Patients Completed NCT01417780 Phase 2 AB103 0.25 mg/kg;AB103 0.5 mg/kg;NaCl 0.9%
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed Preparation Unknown status NCT02314468 Not Applicable
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Completed NCT01790698
7 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
8 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
9 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
10 RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections Recruiting NCT02025816
11 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
12 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Not Applicable Hyperbaric oxygen
13 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
14 Hyperglycemia in Surgical Infections Terminated NCT00353275 Not Applicable Strict Glycemic control;Conventional Glycemic Control

Search NIH Clinical Center for Necrotizing Soft Tissue Infection

Genetic Tests for Necrotizing Soft Tissue Infection

Anatomical Context for Necrotizing Soft Tissue Infection

MalaCards organs/tissues related to Necrotizing Soft Tissue Infection:

41
Skin, Appendix, Liver, Colon, Spinal Cord

Publications for Necrotizing Soft Tissue Infection

Articles related to Necrotizing Soft Tissue Infection:

(show top 50) (show all 68)
# Title Authors Year
1
Bowel Perforation Resulting in Necrotizing Soft-Tissue Infection of the Abdomen, Flank, and Lower Extremities. ( 29893614 )
2018
2
Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis. ( 29672405 )
2018
3
Can necrotizing soft tissue infection be reliably diagnosed in the emergency department? ( 29766136 )
2018
4
Retroperitoneal Necrotizing Soft Tissue Infection Presenting as a Concern for Missed Hollow Viscus Injury. ( 29559069 )
2018
5
A Case of Severe Lumbar Necrotizing Soft Tissue Infection from an Ileal Pouch Fistula. ( 29957139 )
2018
6
Optimal timing of initial debridement for necrotizing soft tissue infection: A Practice Management Guideline from the Eastern Association for the Surgery of Trauma. ( 29485428 )
2018
7
Open-to-Air Is a Viable Option for Initial Wound Care in Necrotizing Soft Tissue Infection that Allows Early Detection of Recurrence without Need for Painful Dressing Changes or Return to Operating Room. ( 29211657 )
2018
8
<i>Stenotrophomonas maltophilia</i> Necrotizing Soft Tissue Infection in an Immunocompromised Patient. ( 29805813 )
2018
9
Necrotizing soft tissue infection following femoral venous catheter infection. ( 29387911 )
2018
10
Unusual complication of bladder prolapse with subsequent diagnosis of urothelial carcinoma leading to a necrotizing soft tissue infection after radical cystectomy. ( 29977515 )
2018
11
Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province. ( 29281989 )
2017
12
Necrotizing soft tissue infection of the thigh associated with retroperitoneal abscess in a patient with locally advanced ascending colon cancer: A case report. ( 29124012 )
2017
13
Effect of transfer status on outcomes for necrotizing soft tissue infections. ( 29180205 )
2017
14
Fistulating Richter's Hernia of Groin with Necrotizing Soft Tissue Infection: A Lethal Combination. ( 28892969 )
2017
15
A Woman with a Necrotizing Soft-Tissue Infection. ( 29190840 )
2017
16
Retroperitoneal Necrotizing Soft Tissue Infection in a Healthy Adult Masquerading as Acute Pancreatitis. ( 28188947 )
2017
17
Necrotizing Soft Tissue Infection or Sweet Syndrome: Surgery Versus No Surgery?: A Case Report. ( 28151765 )
2017
18
Ureaplasma urealyticum necrotizing soft tissue infection. ( 28803865 )
2017
19
Calculated decisions: LRINEC Score for necrotizing soft-tissue infection ( 29068632 )
2017
20
Successful treatment of a rare extended retroperitoneal necrotizing soft tissue infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: A case report. ( 27930570 )
2016
21
Pentraxin-3 to better delineate necrotizing soft tissue infection: not really! ( 27311489 )
2016
22
Necrotizing Soft Tissue Infection Caused by Spilled Gallstones. ( 27144208 )
2016
23
Failure to decolonize mupirocin and linezolid resistant MRSA from a patient with necrotizing soft tissue infection. ( 26837722 )
2016
24
Necrotizing soft tissue infection: analysis of the factors related to mortality in 30 cases of a single institution for 5 years. ( 27433464 )
2016
25
Necrotizing soft tissue infection caused by Serratia marcescens: A case report and literature review. ( 26778253 )
2016
26
Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study. ( 26880104 )
2016
27
The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection. ( 27355483 )
2016
28
Necrotizing Soft-Tissue Infection of the Thumb: A Case Report. ( 29252576 )
2015
29
Necrotizing soft tissue infection of the right anterolateral abdominal wall caused by a ruptured gangrenous appendix in an elderly diabetic patient. ( 26110301 )
2015
30
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report. ( 25880377 )
2015
31
Necrotizing soft tissue infections after injection therapy: Higher mortality and worse outcome compared to other entry mechanisms. ( 26048202 )
2015
32
Necrotizing soft tissue infection following a peripheral bypass. ( 25733218 )
2015
33
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
34
Fatal Necrotizing Soft Tissue Infection by Aeromonas hydrophila. ( 24959446 )
2014
35
Necrotizing Soft Tissue Infection Occurring after Exposure to Mycobacterium marinum. ( 25506004 )
2014
36
Predictors of mortality in necrotizing soft tissue infection. ( 25264645 )
2014
37
Necrotizing soft-tissue infection: laboratory risk indicator for necrotizing soft tissue infections score. ( 24696561 )
2014
38
Trends in the incidence and treatment of necrotizing soft tissue infections: an analysis of the National Hospital Discharge Survey. ( 25144805 )
2014
39
Necrotizing soft-tissue infection in an adult. ( 24642044 )
2014
40
Necrotizing soft tissue infection with gas formation caused by Vibrio vulnificus and misdiagnosed as Pseudomonas aeruginosa. ( 23158593 )
2013
41
Predictors of mortality and limb loss in necrotizing soft tissue infections. ( 24160808 )
2013
42
Timing of redAcbridement after initial source control impacts survival in necrotizing soft tissue infection. ( 24160803 )
2013
43
Immunocompromised status in patients with necrotizing soft-tissue infection. ( 23677405 )
2013
44
Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes. ( 23163625 )
2013
45
Procalcitonin ratio as a predictor of successful surgical treatment of severe necrotizing soft tissue infections. ( 23806825 )
2013
46
Use of Methylnaltrexone to Induce Laxation in Acutely Injured Patients With Burns and Necrotizing Soft-Tissue Infections. ( 23877147 )
2013
47
A case of Apophysomyces trapeziformis necrotizing soft tissue infection. ( 23891642 )
2013
48
Vulvar necrotizing soft tissue infection: A review of a multi-disciplinary surgical emergency and management in the modern era. ( 24371682 )
2013
49
Development and validation of a necrotizing soft-tissue infection mortality risk calculator using NSQIP. ( 23628224 )
2013
50
A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes. ( 23493729 )
2013

Variations for Necrotizing Soft Tissue Infection

Expression for Necrotizing Soft Tissue Infection

Search GEO for disease gene expression data for Necrotizing Soft Tissue Infection.

Pathways for Necrotizing Soft Tissue Infection

GO Terms for Necrotizing Soft Tissue Infection

Sources for Necrotizing Soft Tissue Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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