ANUG
MCID: NCR001
MIFTS: 40

Necrotizing Ulcerative Gingivitis (ANUG)

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Necrotizing Ulcerative Gingivitis

MalaCards integrated aliases for Necrotizing Ulcerative Gingivitis:

Name: Necrotizing Ulcerative Gingivitis 12 15 17 74
Acute Necrotizing Ulcerative Gingivitis 12 77 54
Vincent's Disease 12 74
Vincent Angina 12 74
Anug 12 54
Acute Necrotising Ulcerative Gingivostomatitis 12
Acute Necrotizing Ulcerative Gingivostomatitis 12
Acute Necrotising Ulcerative Gingivitis 12
Early Acute Necrotising Gingivitis 12
Gingivitis, Necrotizing Ulcerative 45
Acute Ulceromembranous Gingivitis 12
Vincent's Angina - Pharyngitis 12
Vincent's Infection, Any Site 12
Acute Membranous Gingivitis 54
Fusospirillary Gingivitis 54
Phagedenic Gingivitis 54
Vincent's Gingivitis 54
Vincent's Stomatitis 54
Vincent's Infection 54
Angina - Vincents 12
Vincent's Angina 12
Fusospirillosis 54
Trench Mouth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13924
ICD9CM 36 101
MeSH 45 D005892
NCIt 51 C34637
SNOMED-CT 69 30896000
ICD10 34 A69.1

Summaries for Necrotizing Ulcerative Gingivitis

MalaCards based summary : Necrotizing Ulcerative Gingivitis, also known as acute necrotizing ulcerative gingivitis, is related to gingivitis and aphthous stomatitis. An important gene associated with Necrotizing Ulcerative Gingivitis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Th17 cell differentiation and Immune response IL-23 signaling pathway. Affiliated tissues include bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Acute necrotizing ulcerative gingivitis (ANUG; colloquially known as trench mouth) is a common,... more...

Related Diseases for Necrotizing Ulcerative Gingivitis

Diseases related to Necrotizing Ulcerative Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 gingivitis 31.5 GUSB IL1B
2 aphthous stomatitis 29.7 IL10 IL1B
3 systemic lupus erythematosus 28.9 CFB IL10 IL18 IL1B
4 periodontitis 10.3
5 multifocal choroiditis 10.1 CFB IL10
6 choroiditis 10.1 CFB IL10
7 gingival disease 10.1
8 leukemia 10.1
9 noma 10.1
10 tonsillitis 10.1
11 hypoascorbemia 10.0
12 ulcerative stomatitis 10.0
13 mycoplasma pneumoniae pneumonia 10.0 IL10 IL18
14 genital herpes 10.0 IL10 IL18
15 acute graft versus host disease 10.0 IL10 IL18
16 melioidosis 10.0 IL10 IL18
17 brucellosis 10.0 IL10 IL18
18 balanitis 10.0
19 pellagra 10.0
20 alcoholic gastritis 9.9 IL18 IL1B
21 schnitzler syndrome 9.9 IL18 IL1B
22 uremic pruritus 9.9 IL18 IL1B
23 periodontitis, chronic 9.9
24 acute lymphocytic leukemia 9.9
25 lymphocytic leukemia 9.9
26 von willebrand's disease 9.9
27 bruxism 9.9
28 lupus erythematosus 9.9
29 stomatitis 9.9
30 periodontosis 9.9
31 stachybotrys chartarum 9.9 IL18 IL1B
32 cysticercosis 9.9 IL18 IL1B
33 adult-onset still's disease 9.9 IL18 IL1B
34 familial cold autoinflammatory syndrome 9.9 IL18 IL1B
35 funisitis 9.9 IL10 IL1B
36 autoimmune gastritis 9.9 IL10 IL1B
37 fascioliasis 9.9 IL10 IL1B
38 primary systemic mycosis 9.9 IL10 IL1B
39 eales disease 9.9 IL10 IL1B
40 acute disseminated encephalomyelitis 9.9 IL10 IL1B
41 aseptic meningitis 9.9 IL10 IL1B
42 scrub typhus 9.9 IL10 IL1B
43 lacrimal apparatus disease 9.9 IL10 IL1B
44 salmonellosis 9.9 IL18 IL1B
45 commensal bacterial infectious disease 9.9 IL10 IL1B
46 extrapulmonary tuberculosis 9.9 IL10 IL1B
47 q fever 9.9 IL10 IL1B
48 complex regional pain syndrome 9.9 IL10 IL1B
49 viral encephalitis 9.8 IL10 IL1B
50 keratoconjunctivitis sicca 9.8 IL10 IL1B

Graphical network of the top 20 diseases related to Necrotizing Ulcerative Gingivitis:



Diseases related to Necrotizing Ulcerative Gingivitis

Symptoms & Phenotypes for Necrotizing Ulcerative Gingivitis

MGI Mouse Phenotypes related to Necrotizing Ulcerative Gingivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 BSG CFB GUSB IL10 IL18 IL1B
2 homeostasis/metabolism MP:0005376 9.7 CFB GLA GUSB IL10 IL18 IL1B
3 immune system MP:0005387 9.5 BSG CFB GLA IL10 IL18 IL1B
4 integument MP:0010771 9.02 GUSB IL10 IL18 IL1B PTGES

Drugs & Therapeutics for Necrotizing Ulcerative Gingivitis

Search Clinical Trials , NIH Clinical Center for Necrotizing Ulcerative Gingivitis

Cochrane evidence based reviews: gingivitis, necrotizing ulcerative

Genetic Tests for Necrotizing Ulcerative Gingivitis

Anatomical Context for Necrotizing Ulcerative Gingivitis

MalaCards organs/tissues related to Necrotizing Ulcerative Gingivitis:

42
Bone

Publications for Necrotizing Ulcerative Gingivitis

Articles related to Necrotizing Ulcerative Gingivitis:

(show top 50) (show all 107)
# Title Authors Year
1
Adjunct Use of Low-Level Laser Therapy on the Treatment of Necrotizing Ulcerative Gingivitis: A Case Report. ( 29399316 )
2018
2
Unexpected Acute Necrotizing Ulcerative Gingivitis in a Well-controlled HIV-infected Case. ( 28781315 )
2017
3
Necrotizing Ulcerative Gingivitis. ( 29042743 )
2017
4
Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study. ( 27830369 )
2016
5
Complete Genome Sequence for Treponema sp. OMZ 838 (ATCC 700772, DSM 16789), Isolated from a Necrotizing Ulcerative Gingivitis Lesion. ( 25540346 )
2014
6
Managing patients with necrotizing ulcerative gingivitis. ( 23763733 )
2013
7
Necrotizing ulcerative gingivitis and the orthodontic patient: a case series. ( 23524550 )
2013
8
The phylum Synergistetes in gingivitis and necrotizing ulcerative gingivitis. ( 22878253 )
2012
9
Prevalence of necrotizing ulcerative gingivitis and associated factors in Koranic boarding schools in Senegal. ( 22779382 )
2012
10
Necrotizing ulcerative gingivitis: a discussion of four dissimilar presentations. ( 22206178 )
2011
11
Images in emergency medicine. Acute necrotizing ulcerative gingivitis. ( 16492485 )
2006
12
Inflammatory cytokine profile and circulating cortisol levels in malnourished children with necrotizing ulcerative gingivitis. ( 16266866 )
2005
13
Acute necrotizing ulcerative gingivitis and bacteremia caused by Stenotrophomonas maltophilia in an immunocompromised host. ( 15702051 )
2005
14
Gingival crevice microbiota from Chinese patients with gingivitis or necrotizing ulcerative gingivitis. ( 14871191 )
2004
15
Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. ( 15280279 )
2004
16
The epidemiology, etiology, and pathophysiology of acute necrotizing ulcerative gingivitis associated with malnutrition. ( 15318254 )
2004
17
Acute myelogenous leukemia complicated by acute necrotizing ulcerative gingivitis due to Aspergillus terreus. ( 12769350 )
2003
18
Oral pemphigoid masquerading as necrotizing ulcerative gingivitis in a child. ( 12083540 )
2002
19
Treponema parvum sp. nov., a small, glucoronic or galacturonic acid-dependent oral spirochaete from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. ( 11411720 )
2001
20
Necrotizing ulcerative gingivitis. ( 10863376 )
1999
21
Acute necrotizing ulcerative gingivitis-periodontitis: a literature review. ( 9597852 )
1998
22
Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. ( 9467378 )
1997
23
Severity of necrotizing ulcerative gingivitis in Nigerian children. ( 9055679 )
1995
24
Case #1. Acute necrotizing ulcerative gingivitis. ( 8619074 )
1995
25
Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors. ( 8558402 )
1995
26
Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. ( 9673175 )
1994
27
Oral hygiene status and necrotizing ulcerative gingivitis in Nigerian children. ( 8295093 )
1993
28
Serum IgG and IgM levels to bacterial antigens in necrotizing ulcerative gingivitis. ( 8463942 )
1993
29
Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. ( 1713299 )
1991
30
The treatment of acute necrotizing ulcerative gingivitis. ( 2068255 )
1991
31
Acute necrotizing ulcerative gingivitis is associated with attachment loss. ( 1753002 )
1991
32
Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis. ( 1855985 )
1991
33
The problem of the taxonomy of the fusiform bacillus of acute necrotizing ulcerative gingivitis (Vincent's gingivitis). ( 2196849 )
1990
34
Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles. ( 2087354 )
1990
35
Acute necrotizing ulcerative gingivitis associated with von Willebrand's disease: a case report. ( 2150929 )
1990
36
Necrotizing ulcerative gingivitis and cancrum oris (noma) in Ibadan, Nigeria. ( 2269918 )
1990
37
Allelic variants for complement factors C3, C4, and B in acute necrotizing ulcerative gingivitis. ( 3163352 )
1988
38
A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis. ( 3163353 )
1988
39
Epidemiology of acute necrotizing ulcerative gingivitis. ( 3066627 )
1988
40
Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment. ( 3514841 )
1986
41
Peripheral blood phagocyte function in acute necrotizing ulcerative gingivitis. ( 2941561 )
1986
42
Acute necrotizing ulcerative gingivitis: etiology and stress relationships. ( 3462166 )
1986
43
Necrotizing ulcerative gingivitis in the military from ancient to modern times. ( 3935959 )
1985
44
ABC's periodontics. "N" is for necrotizing ulcerative gingivitis. ( 3866022 )
1985
45
Necrotizing ulcerative gingivitis in beagle dogs. III. Distribution of spirochetes in interdental gingival tissue. ( 2934537 )
1985
46
Acute necrotizing ulcerative gingivitis in a case of systemic lupus erythematosus. ( 3855317 )
1985
47
Necrotizing ulcerative gingivitis in beagle dogs. I. Attempts at unilateral induction and intraoral transmission of NUG, a microbiological and clinical study. ( 6232371 )
1984
48
Necrotizing ulcerative gingivitis in beagle dogs. II. Histologic characteristics of NUG in relation to interproximal contacts. ( 6232372 )
1984
49
Acute necrotizing ulcerative gingivitis: a review. ( 6594833 )
1984
50
Acute necrotizing ulcerative gingivitis: clinical features, etiology and treatment. ( 6585327 )
1984

Variations for Necrotizing Ulcerative Gingivitis

Expression for Necrotizing Ulcerative Gingivitis

Search GEO for disease gene expression data for Necrotizing Ulcerative Gingivitis.

Pathways for Necrotizing Ulcerative Gingivitis

Pathways related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 IL10 IL18 IL1B
2
Show member pathways
12.28 IL10 IL18 IL1B
3
Show member pathways
11.97 IL10 IL18 IL1B
4 11.89 IL10 IL18 IL1B
5
Show member pathways
11.8 IL10 IL18 IL1B
6
Show member pathways
11.72 IL10 IL18 IL1B
7 11.64 IL10 IL18 IL1B
8 11.44 CFB IL10
9 11.4 IL10 IL18 IL1B
10 11.33 IL18 IL1B
11 11.28 IL10 IL18 IL1B
12 11.25 IL18 IL1B
13 11.17 IL18 IL1B
14 11.09 IL10 IL1B
15 11.04 IL18 IL1B
16 11.02 IL10 IL18 IL1B
17 10.99 IL10 IL1B
18 10.91 IL18 IL1B
19 10.88 IL10 IL18 IL1B
20 10.84 IL18 IL1B
21 10.82 IL10 IL18 IL1B
22 10.37 IL10 IL18 IL1B
23 10.21 IL18 IL1B

GO Terms for Necrotizing Ulcerative Gingivitis

Cellular components related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.65 BSG CFB GLA GUSB IL1B
2 extracellular space GO:0005615 9.35 CFB GUSB IL10 IL18 IL1B
3 lysosome GO:0005764 9.33 GLA GUSB IL1B
4 extracellular region GO:0005576 9.1 CFB GLA GUSB IL10 IL18 IL1B

Biological processes related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.72 IL10 IL18 IL1B
2 cytokine-mediated signaling pathway GO:0019221 9.67 IL10 IL18 IL1B
3 response to lipopolysaccharide GO:0032496 9.61 IL10 IL1B PTGES
4 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.52 IL18 IL1B
5 positive regulation of interferon-gamma production GO:0032729 9.51 IL18 IL1B
6 embryo implantation GO:0007566 9.48 BSG IL1B
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 IL18 IL1B
8 negative regulation of nitric oxide biosynthetic process GO:0045019 9.4 GLA IL10
9 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 IL10 IL1B
10 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.32 IL18 IL1B
11 interleukin-6 production GO:0032635 9.26 IL18 IL1B
12 response to peptide hormone GO:0043434 9.24 BSG
13 positive regulation of neuroinflammatory response GO:0150078 9.16 IL18 IL1B
14 positive regulation of T-helper 1 cell cytokine production GO:2000556 8.96 IL18 IL1B
15 type 2 immune response GO:0042092 8.62 IL10 IL18

Molecular functions related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL10 IL18 IL1B

Sources for Necrotizing Ulcerative Gingivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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