Nelson Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A rare, acquired, endocrine disease characterized by the triad of diffuse skin and mucosa hyperpigmentation, markedly elevated serum adrenocorticotropin (ACTH) levels and an enlarging corticotroph adenoma, which manifest following total bilateral adrenalectomy performed for the treatment of Cushing's disease. Additionally, patients may present with headaches, visual field defects, cranial nerve palsy, pituitary apoplexy, diabetes insipidus, panhypopituitarism, and, occasionally, paraovarian or paratesticular tumors.

MalaCards based summary: Nelson Syndrome, also known as nelson's syndrome, is related to central diabetes insipidus and diabetes insipidus. An important gene associated with Nelson Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Signal Transduction and Transcriptional Regulation by MECP2. The drugs Pasireotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, skin and adrenal cortex, and related phenotypes are adrenocorticotropic hormone excess and secondary hypercortisolism

GARD: ¹⁹ A rare, acquired, endocrine disease characterized by the triad of diffuse skin and mucosa hyperpigmentation, markedly elevated serum adrenocorticotropin (ACTH) levels and an enlarging corticotroph adenoma, which manifest following total bilateral adrenalectomy performed for the treatment of Cushing's disease. Additionally, patients may present with headaches, visual field defects, cranial nerve palsy, pituitary apoplexy, diabetes inspidus, panhypopituitarism, and, occasionally, paraovarian or paratesticular tumors.

Wikipedia: ⁷⁵ Nelson's syndrome is a disorder that occurs in about one in four patients who have had both adrenal... more...

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Related Diseases for Nelson Syndrome

Diseases related to Nelson Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)

#	Related Disease	Score	Top Affiliating Genes
1	central diabetes insipidus	30.6	PRL POMC
2	diabetes insipidus	30.6	PRL POMC CRH
3	empty sella syndrome	30.4	PRL POMC
4	premature ovarian failure 7	30.2	POMC CRH
5	amenorrhea	30.2	PRL POMC CRH
6	chromophobe adenoma	30.2	PRL POMC
7	abducens palsy	30.2	PRL POMC
8	cranial nerve palsy	30.1	PRL POMC
9	personality disorder	30.0	PRL NR3C1 CRH
10	pituitary tumors	30.0	SSTR5 SST PRL
11	pituitary apoplexy	30.0	SST PRL POMC
12	hyperprolactinemia	30.0	SST PRL POMC
13	adrenal carcinoma	30.0	SST POMC CRH
14	hypopituitarism	29.9	TBX19 PRL POMC CRH
15	pituitary hormone deficiency, combined, 2	29.8	PRL POMC
16	hypoglycemia	29.7	SST PRL POMC NR3C1 CRH
17	lipoid congenital adrenal hyperplasia	29.7	PRL POMC NR3C1 CRH
18	mccune-albright syndrome	29.7	USP8 SST PRL POMC
19	acromegaly	29.6	SSTR5 SST PRL POMC CRH
20	pituitary-dependent cushing's disease	29.5	USP8 USP48 SST PRL POMC NR3C1
21	adenoma	29.4	USP8 SSTR5 SST PRL POMC MGMT
22	pituitary adenoma	29.2	USP8 SSTR5 SST PRL POMC NR3C1
23	pituitary infarct	29.2	TBX19 SST PRL POMC CRH
24	conn's syndrome	28.7	USP8 USP48 TBX19 SST PRL PPARG
25	pituitary gland disease	28.4	USP8 TBX19 SSTR5 SST PRL POMC
26	pituitary cancer	27.9	USP8 USP48 TBX19 SSTR5 SST PRL
27	functioning pituitary adenoma	27.9	USP8 USP48 TBX19 SSTR5 SST PRL
28	acth-secreting pituitary adenoma	27.7	USP8 USP48 TBX19 SSTR5 SST PRL
29	dermal ridges-off-the-end	11.7
30	hand and foot deformity with flat facies	11.5
31	hypohidrosis with abnormal palmar dermal ridges	11.4
32	dubin-johnson syndrome	11.2
33	dermal ridges, nelson syndrome	11.1
34	pituitary adenoma 4, acth-secreting	10.3
35	bronchial adenomas/carcinoids childhood	10.3	SST POMC
36	functionless pituitary adenoma	10.3	SST POMC
37	waterhouse-friderichsen syndrome	10.3	POMC CRH
38	thyroid dyshormonogenesis 2a	10.2	SST POMC
39	tuberculum sellae meningioma	10.2	PRL POMC
40	somatization disorder	10.2	POMC CRH
41	sella turcica neoplasm	10.2	PRL POMC
42	alzheimer disease 16	10.2	POMC NR3C1
43	melanotic neurilemmoma	10.2	PRL POMC
44	neurotic disorder	10.2	POMC CRH
45	retrograde amnesia	10.2	POMC CRH
46	cranial nerve malignant neoplasm	10.2	SST POMC
47	pancreatic endocrine carcinoma	10.2	SST POMC
48	partial third-nerve palsy	10.2	PRL POMC
49	adjustment disorder	10.2	POMC CRH
50	ovarian serous adenofibroma	10.2	POMC NR3C1

Graphical network of the top 20 diseases related to Nelson Syndrome:

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Symptoms & Phenotypes for Nelson Syndrome

Human phenotypes related to Nelson Syndrome:

⁵⁸ ³⁰ (show all 28)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	adrenocorticotropic hormone excess ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0011749
2	secondary hypercortisolism ³⁰	Obligate (100%)		HP:0011744
3	increased urinary cortisol level ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0012030
4	pituitary corticotropic cell adenoma ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0008291
5	hypertension ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000822
6	type ii diabetes mellitus ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005978
7	hypokalemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002900
8	striae distensae ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001065
9	generalized hyperpigmentation ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007440
10	bitemporal hemianopia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030521
11	slow decrease in visual acuity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007924
12	lower limb muscle weakness ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0007340
13	abnormal kinetic perimetry test ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030591
14	increased intracranial pressure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002516
15	anterior hypopituitarism ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000830
16	oculomotor nerve palsy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0012246
17	optic nerve compression ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0007807
18	quadriceps muscle atrophy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0009050
19	diabetes insipidus ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000873
20	intracranial hemorrhage ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002170
21	testicular neoplasm ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0010788
22	pituitary carcinoma ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0011763
23	increased circulating prolactin concentration ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000870
24	ocular pain ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0200026
25	abnormality of the sphenoid sinus ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0430022
26	visual impairment ⁵⁸		Frequent (79-30%)
27	increased circulating cortisol level ⁵⁸		Very frequent (99-80%)
28	secondary hypercorticolism ⁵⁸		Obligate (100%)

MGI Mouse Phenotypes related to Nelson Syndrome:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.91	CABLES1 CRH MGMT NR3C1 POMC PPARG
2	no phenotypic analysis	MP:0003012	9.8	CRH MGMT NR3C1 POMC PPARG SST
3	neoplasm	MP:0002006	9.77	CABLES1 MGMT POMC PPARG PRL
4	homeostasis/metabolism	MP:0005376	9.65	CRH MGMT NR3C1 POMC PPARG PRL
5	liver/biliary system	MP:0005370	9.63	CRH NR3C1 POMC PPARG PRL USP8
6	endocrine/exocrine gland	MP:0005379	9.28	CABLES1 CRH MGMT NR3C1 POMC PPARG

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Drugs & Therapeutics for Nelson Syndrome

Drugs for Nelson Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pasireotide

Approved

Phase 2

396091-73-9

56841596 9941444

2

Hormones

Phase 2

3

Hormone Antagonists

Phase 2

4

Adrenocorticotropic Hormone

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Multicenter, Single Arm Study of Pasireotide LAR in Patients With Rare Tumors of Neuroendocrine Origin	Terminated	NCT00958841	Phase 2	pasireotide LAR
2	An Open Label, Longitudinal Study of the Effects of Subcutaneous Acute and Chronic Pasireotide (som230) Therapy on Adrenocorticotrophic Hormone and Tumour Volume in Patients With Nelson's Syndrome	Terminated	NCT01617733	Phase 2	Pasireotide

Search NIH Clinical Center for Nelson Syndrome

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Cyproheptadine

Cyproheptadine hydrochloride

CYPROHEPTADINE HYDROCHLORIDE MONOHYDRATE

Cochrane evidence based reviews: nelson syndrome

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Genetic Tests for Nelson Syndrome

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Anatomical Context for Nelson Syndrome

Organs/tissues related to Nelson Syndrome:

MalaCards : Pituitary, Skin, Adrenal Cortex, Adrenal Gland, Kidney, Tongue, Brain

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Publications for Nelson Syndrome

Articles related to Nelson Syndrome:

(show top 50) (show all 599)

#	Title	Authors	PMID	Year
1	No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo. ⁵³ ⁶²	Kreutzer J...Buslei R	19919817	2009
2	Plasma galanin, vasopressin, and oxytocin in patients with Addison's disease. ⁵³ ⁶²	Grenback E...Petersson M	17712724	2007
3	ACTH responses to somatostatin, valproic acid and dexamethasone in Nelson's syndrome. ⁵³ ⁶²	Kasperlik-Zaluska AA...Zdunowski P	16380696	2005
4	Adrenocorticotropin hypersecretion and pituitary microadenoma following bilateral adrenalectomy in a patient with classic 21-hydroxylase deficiency. ⁵³ ⁶²	Charmandari E...Merke DP	15679075	2005
5	The role of somatostatin analogs in Cushing's disease. ⁵³ ⁶²	van der Hoek J...Hofland LJ	16132202	2004
6	Corticosteroid resistance and disease. ⁵³ ⁶²	DeRijk R...Sternberg EM	9073327	1997
7	Is there a role for somatostatin and its analogs in Cushing's syndrome? ⁵³ ⁶²	de Herder WW...Lamberts SW	8769391	1996
8	Somatostatin analogue treatment of neuroendocrine tumours. ⁵³ ⁶²	de Herder WW...Lamberts SW	8935599	1996
9	Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene. ⁵³ ⁶²	Karl M...Schulte HM	8550738	1996
10	Clinical and analytical evaluation of an immunoradiometric assay for corticotropin. ⁵³ ⁶²	Rosano TG...Leinung M	7600682	1995
11	Glucocorticosteroid resistance in humans. Elucidation of the molecular mechanisms and implications for pathophysiology. ⁵³ ⁶²	Stratakis CA...Chrousos GP	7825890	1994
12	Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors. ⁵³ ⁶²	Vieau D...Bertagna X	7962350	1994
13	Long-term treatment of Nelson's syndrome by octreotide: a case report. ⁵³ ⁶²	Petrini L...Martino E	8006335	1994
14	Multiple forms of bioactive and immunoreactive adrenocorticotropin in human pituitary and blood of patients with Nelson's syndrome. ⁵³ ⁶²	Goverde HJ...Smals AG	8393886	1993
15	Demonstration of pro-opiomelanocortin mRNA in pituitary adenomas and para-adenomatous gland in Cushing's disease and Nelson's syndrome. ⁵³ ⁶²	Fehn M...McNicol AM	8492226	1993
16	Structure of the POMC promoter region in pituitary and extrapituitary ACTH producing tumors. ⁵³ ⁶²	Monig H...Schulte HM	8386673	1993
17	Radiation therapy of pituitary tumors: results in 95 cases. ⁵³ ⁶²	Tran LM...Parker RG	1987733	1991
18	Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN. ⁶²	Valassi E...Reincke M	36197784	2022
19	Management of Nelson's Syndrome. ⁶²	Fountas A...Karavitaki N	36363537	2022
20	The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas. ⁶²	Andonegui-Elguera S...Mercado M	35563252	2022
21	Stereotactic radiosurgery for Nelson's syndrome: A meta-analysis and systematic review of clinical outcomes. ⁶²	Wu Y...Wang W	35031183	2022
22	Defining Wound Healing Progression in Cetacean Skin: Characteristics of Full-Thickness Wound Healing in Fraser's Dolphins (Lagenodelphis hosei). ⁶²	Su CY...Yang WC	35268108	2022
23	The Dermal Ridges as the Infallible Signature of Skin: An Overview. ⁶²	Sudha PI...Sodhi GS	35283510	2021
24	Gamma knife radiosurgery in patients with Nelson's syndrome. ⁶²	Losa M...Mortini P	33611756	2021
25	Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis. ⁶²	Papakokkinou E...Ragnarsson O	34036460	2021
26	Multivariable analysis of 63 contemporary patients diagnosed with nelson's syndrome: A nationwide readmission database study. ⁶²	Shahrestani S...Zada G	34509260	2021
27	Exceptional Response of Nelson's Syndrome to Pasireotide LAR in the Long-Term Follow-up of 9 Years. ⁶²	Fill SM...Athanasoulia-Kaspar AP	33184804	2021
28	A new species of Leptobrachella (Anura, Megophryidae) from Mount Pu Ta Leng, northwest Vietnam. ⁶²	Nguyen LT...Rowley JJL	34810445	2021
29	Association between Dermatoglyphics and Early Childhood Caries among Preschool Children: A Pilot Study. ⁶²	Uma E...Kyaw Soe HH	34458116	2021
30	Stereotactic radiosurgery before bilateral adrenalectomy is associated with lowered risk of Nelson's syndrome in refractory Cushing's disease patients. ⁶²	Bunevicius A...Sheehan J	33759014	2021
31	Corticotroph tumor progression during long-term therapy with osilodrostat in a patient with persistent Cushing's disease. ⁶²	Fontaine-Sylvestre C...Lacroix A	33074401	2021
32	Updates in the outcomes of radiation therapy for Cushing's disease. ⁶²	Gheorghiu ML	33814300	2021
33	High Prevalence of Adrenal Remnant Tissue in Patients Undergoing Bilateral Adrenalectomy for Cushing's Disease. ⁶²	Wilson JB...Friedman TC	33091942	2021
34	Nelson Syndrome: Clival Invasion of Corticotroph Pituitary Adenoma Resulting in Alternating Sixth Nerve Palsies. ⁶²	Douglas VP...Chwalisz BK	33394640	2021
35	Nelson Syndrome: A Case Report and Literature Review. ⁶²	Esparza-Salazar FJ...Gomez-Samano MA	34095473	2021
36	Corticotroph tumor progression after bilateral adrenalectomy (Nelson's syndrome): systematic review and expert consensus recommendations. ⁶²	Reincke M...Ritzel K	33444221	2021
37	Dermatoglyphics: A Noninvasive Diagnostic Tool in Predicting Class III Skeletal Malocclusion in Children. ⁶²	Belludi AC...Noojadi SR	34326586	2021
38	Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ⁶²	Yamamoto M...Fukuoka H	34220707	2021
39	Aggressive Pituitary Macroadenoma Treated With Capecitabine and Temozolomide Chemotherapy Combination in a Patient With Nelson's Syndrome: A Case Report. ⁶²	Mirallas O...Capdevila J	34858324	2021
40	Rapid response of Nelson's syndrome to pasireotide in radiotherapy-naive patient. ⁶²	He X...Spencer-Segal JL	33292741	2020
41	ACTH increment post total bilateral adrenalectomy for Cushing's disease: a consistent biosignature for predicting Nelson's syndrome. ⁶²	Das L...Walia R	32449103	2020
42	Nelson's Syndrome: An Update. ⁶²	Fountas A...Karavitaki N	32741480	2020
43	A new species of Leptobrachella (Anura: Megophryidae) Smith, 1925 from Wuling Mountains in Hunan Province, China. ⁶²	Qian TY...Yang DD	33055685	2020
44	Metastatic Pituitary Carcinoma Causing Cord Compression. ⁶²	Soon WC...Dhir J	32289505	2020
45	Letting in Some Light on Nelson's Syndrome. ⁶²	Grossman A	31853553	2020
46	Outcomes of Patients with Nelson's Syndrome after Primary Treatment: A Multicenter Study from 13 UK Pituitary Centers. ⁶²	Fountas A...Karavitaki N	31735971	2020
47	The importance of landmarks in endoscopic endonasal reinterventions: the transpterygoid transcavernous approach. ⁶²	Martinez-Perez R...Prevedello DM	31912353	2020
48	Cushing's syndrome - Disease monitoring: Recurrence, surveillance with biomarkers or imaging studies. ⁶²	Ragnarsson O	32139169	2020
49	THE NOVEL USE OF STEREOTACTIC RADIOTHERAPY FOR REMNANT ADRENAL TISSUE IN NELSON SYNDROME. ⁶²	Martirossian AN...Vaughan TB	33163624	2020
50	Pituitary Adenoma Deposit in the Nasolabial Region Following Sublabial Transsphenoidal Surgery in the Setting of Nelson Syndrome. ⁶²	Wallace A...Portugal L	31633667	2020

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Genes for Nelson Syndrome

Genes related to Nelson Syndrome (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	POMC	Proopiomelanocortin	Protein Coding	17.98	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17712724 8769391 15679075 (more) 7962350 8492226 8393886 8386673
2	SST	Somatostatin	Protein Coding	13.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8769391 16380696 8935599 (more) 16132202 8006335
3	CRH	Corticotropin Releasing Hormone	Protein Coding	13.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7600682
4	PRL	Prolactin	Protein Coding	12.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1987733
5	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	12.35	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	10.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8550738 9073327 7825890
7	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	8.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19919817
8	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	6.56	DISEASES inferred ¹⁴
9	SSTR5	Somatostatin Receptor 5	Protein Coding	6.22	DISEASES inferred ¹⁴
10	USP48	Ubiquitin Specific Peptidase 48	Protein Coding	5.92	DISEASES inferred ¹⁴
11	TBX19	T-Box Transcription Factor 19	Protein Coding	5.52	DISEASES inferred ¹⁴
12	CABLES1	Cdk5 And Abl Enzyme Substrate 1	Protein Coding	5.52	DISEASES inferred ¹⁴

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Variations for Nelson Syndrome

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Expression for Nelson Syndrome

Search GEO for disease gene expression data for Nelson Syndrome.

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Pathways for Nelson Syndrome

Pathways related to Nelson Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.21	USP8 SSTR5 SST PPARG POMC NR3C1
2	Transcriptional Regulation by MECP2 ⁶⁶ Show member pathways Competing endogenous RNAs (ceRNAs) regulate PTEN translation ⁶⁶ Disorders of Developmental Biology ⁶⁶ Disorders of Nervous System Development ⁶⁶ Loss of function of MECP2 in Rett syndrome ⁶⁶ Loss of MECP2 binding ability to 5hmC-DNA ⁶⁶ Loss of MECP2 binding ability to 5mC-DNA ⁶⁶ Loss of MECP2 binding ability to the NCoR/SMRT complex ⁶⁶ Loss of phosphorylation of MECP2 at T308 ⁶⁶ MECP2 regulates neuronal receptors and channels ⁶⁶ MECP2 regulates transcription factors ⁶⁶ MECP2 regulates transcription of genes involved in GABA signaling ⁶⁶ MECP2 regulates transcription of neuronal ligands ⁶⁶ Pervasive developmental disorders ⁶⁶ Post-transcriptional silencing by small RNAs ⁶⁶ PTEN Loss of Function in Cancer ⁶⁶ Regulation of MECP2 expression and activity ⁶⁶ Regulation of PTEN mRNA translation ⁶⁶	11.99	SST PPARG CRH
3	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.29	TBX19 POMC CRH
4	Glucocorticoid receptor regulatory network ⁶¹	11.02	PRL POMC NR3C1
5	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	10.94	PRL NR3C1
6	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	10.87	POMC CRH
7	Transcription factor regulation in adipogenesis ⁷⁴	10.71	PPARG NR3C1
8	Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics ⁶⁰	10.62	PRL POMC
9	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	9.47	POMC CRH

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GO Terms for Nelson Syndrome

Biological processes related to Nelson Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose homeostasis	GO:0042593	9.35	SSTR5 PPARG POMC
2	positive regulation of miRNA transcription	GO:1902895	9.1	PRL PPARG NR3C1

Molecular functions related to Nelson Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.23	SST PRL POMC CRH

Sources

Sources for Nelson Syndrome

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: NLS001 MIFTS: 46	Nelson Syndrome Categories: Endocrine diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Nelson Syndrome

Aliases & Classifications for Nelson Syndrome

MalaCards integrated aliases for Nelson Syndrome:

Classifications:

External Ids:

Summaries for Nelson Syndrome

Related Diseases for Nelson Syndrome

Diseases related to Nelson Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Nelson Syndrome:

Symptoms & Phenotypes for Nelson Syndrome

Human phenotypes related to Nelson Syndrome:

MGI Mouse Phenotypes related to Nelson Syndrome:

Drugs & Therapeutics for Nelson Syndrome

Drugs for Nelson Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: nelson syndrome

Genetic Tests for Nelson Syndrome

Anatomical Context for Nelson Syndrome

Organs/tissues related to Nelson Syndrome:

Publications for Nelson Syndrome

Articles related to Nelson Syndrome:

Genes for Nelson Syndrome

Genes related to Nelson Syndrome (0 elite genes):

Variations for Nelson Syndrome

Expression for Nelson Syndrome

Pathways for Nelson Syndrome

Pathways related to Nelson Syndrome according to GeneCards Suite gene sharing:

GO Terms for Nelson Syndrome

Biological processes related to Nelson Syndrome according to GeneCards Suite gene sharing:

Molecular functions related to Nelson Syndrome according to GeneCards Suite gene sharing:

Sources for Nelson Syndrome

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :