MCID: NNT054
MIFTS: 15

Neonatal Alloimmune Neutropenia

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Neonatal Alloimmune Neutropenia

MalaCards integrated aliases for Neonatal Alloimmune Neutropenia:

Name: Neonatal Alloimmune Neutropenia 58

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

ICD10 via Orphanet 33 P61.5
Orphanet 58 ORPHA464370

Summaries for Neonatal Alloimmune Neutropenia

MalaCards based summary : Neonatal Alloimmune Neutropenia is related to neutropenia and bacterial infectious disease. An important gene associated with Neonatal Alloimmune Neutropenia is FCGR3B (Fc Fragment Of IgG Receptor IIIb). Affiliated tissues include neutrophil and myeloid.

Related Diseases for Neonatal Alloimmune Neutropenia

Diseases related to Neonatal Alloimmune Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neutropenia 30.1 FCGR3B CD177
2 bacterial infectious disease 10.2
3 thrombocytopenia 10.2
4 severe congenital neutropenia 10.1
5 mucositis 10.1
6 acute cystitis 10.1
7 thrombocytosis 10.1
8 hemolytic disease due to fetomaternal alloimmunization 10.1
9 leukemia, chronic myeloid 9.2 FCGR3B CD177

Graphical network of the top 20 diseases related to Neonatal Alloimmune Neutropenia:



Diseases related to Neonatal Alloimmune Neutropenia

Symptoms & Phenotypes for Neonatal Alloimmune Neutropenia

Drugs & Therapeutics for Neonatal Alloimmune Neutropenia

Search Clinical Trials , NIH Clinical Center for Neonatal Alloimmune Neutropenia

Genetic Tests for Neonatal Alloimmune Neutropenia

Anatomical Context for Neonatal Alloimmune Neutropenia

MalaCards organs/tissues related to Neonatal Alloimmune Neutropenia:

40
Neutrophil, Myeloid

Publications for Neonatal Alloimmune Neutropenia

Articles related to Neonatal Alloimmune Neutropenia:

(show all 38)
# Title Authors PMID Year
1
Genotyping of human neutrophil antigens 1, 3, 4 and 5 using a novel multiplex polymerase chain reaction. 61
30974499 2019
2
Implication of antibodies against human leukocyte antigen in simultaneous presentation of fetal and neonatal alloimmune thrombocytopenia and neutropenia. 61
30318177 2018
3
Molecular Genetics of the Human Neutrophil Antigens. 61
30498408 2018
4
Neonatal Alloimmune Neutropenia. 61
31049048 2018
5
Flow-Cytometric Analysis of HNA-2 Expression and Phenotypes Among Thai Blood Donors. 61
29611387 2018
6
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia. 61
29451309 2018
7
Anti-human neutrophil antigen-1a, -1b, and -2 antibodies in neonates and children with immune neutropenias analyzed by extracted granulocyte antigen immunofluorescence assay. 61
28833244 2017
8
Antibodies to human neutrophil antigen HNA-4b implicated in a case of neonatal alloimmune neutropenia. 61
26749553 2016
9
Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion. 61
27227454 2016
10
Human neutrophil antigen profiles in Banjar, Bugis, Champa, Jawa and Kelantan Malays in Peninsular Malaysia. 61
26057487 2015
11
Management and outcome of 35 cases with foetal/neonatal alloimmune neutropenia. 61
25039288 2014
12
HNA-3 gene frequencies in Brazilians and a new polymerase chain reaction-restriction fragment length polymorphism method for HNA-3a/3b genotyping. 61
24236643 2014
13
Alloimmune neonatal neutropenia in Croatia during the 1998-2008 period. 61
24548251 2014
14
Molecular typing of human platelet and neutrophil antigens (HPA and HNA). 61
24685245 2014
15
Neonatal alloimmune neutropenia: still a diagnostic and therapeutical challenge. 61
22995923 2012
16
Intravenous immunoglobulins for neonatal alloimmune neutropenia refractory to recombinant human granulocyte colony-stimulating factor. 61
21136350 2011
17
[Neonatal alloimmune neutropenia is a frequently overlooked diagnosis in neonates]. 61
21586250 2011
18
Neonatal alloimmune neutropenia due to immunoglobulin G antibodies against human neutrophil antigen-5a. 61
20735765 2011
19
Granulocyte colony stimulating factor in neonatal alloimmune neutropenia: a possible association with induced thrombocytopenia. 61
20135695 2010
20
Dizygotic twins with neonatal alloimmune neutropenia associated with maternal anti-human neutrophil antigen-1B antibody. 61
19379263 2009
21
Establishment of cell lines stably expressing HNA-1a, -1b, and -2a antigen with low background reactivity in flow cytometric analysis. 61
17319829 2007
22
Granulocyte antibodies in Korean neonates with neutropenia. 61
16891804 2006
23
A case of neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-1a (HNA-1a) antibody. 61
16614528 2006
24
Sex-dependent up regulation of CD 177-specific mRNA expression in cord blood due to different stimuli. 61
16398742 2006
25
Neonatal alloimmune neutropenia attributed to maternal immunoglobulin G antibodies against the neutrophil alloantigen HNA-1c (SH): a report of five cases. 61
16078917 2005
26
Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion. 61
15073035 2004
27
Frequency of neutrophil alloantigens by polymerase chain reaction. 61
12070579 2002
28
Neonatal alloimmune neutropenia due to anti-HNA-1b. 61
17159404 2002
29
Resistance to recombinant human granulocyte colony-stimulating factor in neonatal alloimmune neutropenia associated with anti-human neutrophil antigen-2a (NB1) antibodies. 61
11927737 2002
30
Neutrophil alloantigens. 61
11788931 2002
31
[Thrombocyte and leukocyte antigens]. 61
11905185 2001
32
Neonatal alloimmune neutropenia in premature monozygous twins. 61
10920162 2000
33
Neutrophil antigen 5b is carried by a protein, migrating from 70 to 95 kDa, and may be involved in neonatal alloimmune neutropenia. 61
10686007 2000
34
Platelet and neutrophil alloantigen genotyping in clinical practice. 61
9577876 1998
35
Identification of a new white cell antigen. 61
8073489 1994
36
Delayed umbilical cord separation in alloimmune neutropenia. 61
7679889 1993
37
Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia. 61
1532916 1992
38
[Antibodies, clinical and hematologic findings in immunoneutropenias]. 61
2918853 1989

Variations for Neonatal Alloimmune Neutropenia

Expression for Neonatal Alloimmune Neutropenia

Search GEO for disease gene expression data for Neonatal Alloimmune Neutropenia.

Pathways for Neonatal Alloimmune Neutropenia

GO Terms for Neonatal Alloimmune Neutropenia

Cellular components related to Neonatal Alloimmune Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.96 FCGR3B CD177
2 secretory granule membrane GO:0030667 8.62 FCGR3B CD177

Biological processes related to Neonatal Alloimmune Neutropenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 8.62 FCGR3B CD177

Sources for Neonatal Alloimmune Neutropenia

3 CDC
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11 DGIdb
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19 FMA
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32 ICD10
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35 IUPHAR
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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