MCID: NNT011
MIFTS: 33

Neonatal Anemia

Categories: Blood diseases

Aliases & Classifications for Neonatal Anemia

MalaCards integrated aliases for Neonatal Anemia:

Name: Neonatal Anemia 12 15
Anemia, Neonatal 44 73
Anemia Neonatal 12 55

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 44 D000751
SNOMED-CT 68 33130007
UMLS 73 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to thalassemia and beta-thalassemia. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation and Paxillin-dependent events mediated by a4b1. The drugs Heparin and Tinzaparin have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and placenta.

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 thalassemia 29.8 EPO HBA2 HBG1
2 beta-thalassemia 29.5 EPO HBA2 HBG1 KLF1
3 sickle cell anemia 29.4 EPO HBA2 HBG1
4 diamond-blackfan anemia 29.4 EPO EPOR KLF1
5 alpha-thalassemia 29.2 EPO HBA2 HBG1 KLF1
6 elliptocytosis 3 11.1
7 neonatal autoimmune hemolytic anemia 11.1
8 diabetic autonomic neuropathy 10.2 EPO HBA2
9 splenomegaly 10.2 EPO HBA2
10 tubulinopathy-associated dysgyria 10.1 TUBB2B TUBB3
11 acquired polycythemia 10.1 EPO EPOR
12 erythrocytosis, familial, 2 10.1 EPO EPOR
13 ewing's family of tumors 10.1 EPO EPOR
14 tukel syndrome 10.1 TUBB2B TUBB3
15 anemia of prematurity 10.1 EPO EPOR
16 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.1 HBG1 KLF1
17 hemoglobin h disease 10.1 EPO HBA2
18 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 10.1 HBG1 KLF1
19 erythrocytosis, familial, 1 10.1 EPO EPOR
20 paralytic squint 10.1 TUBB2B TUBB3
21 microcytic anemia 10.1 EPO HBA2
22 primary polycythemia 10.1 EPO EPOR
23 tubulin, beta 10.1 TUBB2B TUBB3
24 deficiency anemia 10.0 EPO EPOR HBA2
25 sickle cell disease 10.0 EPO HBA2 HBG1
26 congenital nervous system abnormality 10.0 TUBB2B TUBB3
27 hemangioblastoma 9.9 EPO EPOR
28 hemoglobinopathy 9.9 EPO HBA2 HBG1 KLF1
29 congenital hemolytic anemia 9.9 EPO HBA2 HBG1 KLF1
30 erythroleukemia, familial 9.8 EPO EPOR HBG1 KLF1
31 fetal hemoglobin quantitative trait locus 1 9.8
32 ovalocytosis, southeast asian 9.6
33 pernicious anemia 9.6
34 hydrops fetalis, nonimmune, and/or atrial septal defect 9.6
35 hemolytic anemia 9.6
36 thrombocytopenia 9.6
37 hemosiderosis 9.6
38 megaloblastic anemia 9.6
39 choriocarcinoma 9.6
40 myofibroma 9.6
41 placenta disease 9.6
42 meningitis 9.6
43 fetal edema 9.6
44 hydrops fetalis 9.6

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
2
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
3
Dalteparin Approved Phase 3 9005-49-6
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
5
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
6
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
7 Chelating Agents Phase 3
8 Calcium, Dietary Phase 3
9 Anticoagulants Phase 3,Phase 2
10 Sildenafil Citrate Phase 3 171599-83-0
11 Phosphodiesterase Inhibitors Phase 3
12 Citrate Phase 3
13 Vasodilator Agents Phase 3
14 Phosphodiesterase 5 Inhibitors Phase 3
15 Heparin, Low-Molecular-Weight Phase 3
16 calcium heparin Phase 3
17 Fibrinolytic Agents Phase 3
18 Antimalarials Phase 3
19 Artemisinins Phase 3
20 Artemisinine Phase 3
21 Antiparasitic Agents Phase 3
22 Anti-Infective Agents Phase 3
23 Antiprotozoal Agents Phase 3
24 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
26
Biotin Approved, Investigational, Nutraceutical Phase 2 58-85-5 171548
27 Vitamin B7 Phase 2
28 Vitamins Phase 2
29 Vitamin B9 Phase 2
30 Micronutrients Phase 2
31 Folate Phase 2
32 Trace Elements Phase 2
33 Vitamin B Complex Phase 2
34 Hematinics Phase 2
35 Epoetin alfa Phase 2 113427-24-0
36
Iron Approved Not Applicable 7439-89-6 23925
37
Histidine Approved, Nutraceutical 71-00-1 6274

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
2 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Recruiting NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
3 Improving Maternal heAlth by Reducing Malaria in African HIV Women Not yet recruiting NCT03671109 Phase 3 Dihydroartemisinin-piperaquine (DHA-PPQ);Placebo Oral Tablet
4 Immediate VS Delayed Cord Clamping on Newborns Unknown status NCT01029496 Phase 1, Phase 2
5 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
6 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
7 Optimized Erythropoietin (EPO) Treatment Active, not recruiting NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
8 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
9 Research of Systemic Management for Late Preterm Infants Nutrition in China Unknown status NCT02605577 Not Applicable
10 Milking Versus Delayed Cord Clamping in Full Term Neonates Completed NCT02454101 Not Applicable
11 Identification of Early Predictors of Fetomaternal Hemorrhage Completed NCT01232387
12 Influence of Umbilical Cord Clamping Time in the Newborn Completed NCT03624335 Not Applicable
13 Determinants of Neonatal Anemia in Women Carrying Multiples Active, not recruiting NCT01582802
14 Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea Not yet recruiting NCT03462615

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

41
Testes, Pituitary, Placenta

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show top 50) (show all 53)
# Title Authors Year
1
Epsilon gamma delta beta thalassemia: A rare cause of fetal and neonatal anemia. ( 29162270 )
2018
2
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. ( 28143845 )
2017
3
A Solitary Intestinal Myofibroma: A Rare Cause of Neonatal Anemia. ( 29279689 )
2017
4
Neonatal anemia: Revisiting the enigmatic pyknocyte. ( 28335086 )
2017
5
Management and prevention of neonatal anemia: current evidence and guidelines. ( 24524256 )
2014
6
Severe neonatal anemia from fetomaternal hemorrhage: report from a multihospital health-care system. ( 23196720 )
2013
7
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. ( 23033916 )
2013
8
Imaging diagnosis of neonatal anemia: report of two unusual etiologies. ( 24605254 )
2013
9
A novel epsilon gamma delta beta thalassemia presenting with pregnancy complications and severe neonatal anemia. ( 23206178 )
2013
10
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. ( 22818543 )
2012
11
Clinical and research issues in neonatal anemia and thrombocytopenia. ( 22227780 )
2012
12
Doppler middle cerebral artery peak systolic velocity for diagnosis of neonatal anemia. ( 22922618 )
2012
13
Risk factors of neonatal anemia in placenta previa. ( 21960747 )
2011
14
Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. ( 21481087 )
2011
15
Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia. ( 21388342 )
2011
16
Infantile pyknocytosis: a rare form of neonatal anemia. ( 20684190 )
2010
17
Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). ( 19409822 )
2009
18
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. ( 19371274 )
2009
19
Neonatal anemia. ( 18411074 )
2008
20
Treatment and Prevention of Neonatal Anemia. ( 20209037 )
2008
21
Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. ( 17180133 )
2007
22
Assessment of neonatal anemia. ( 17453046 )
2007
23
Neonatal anemia associated with Southeast Asian ovalocytosis. ( 16207591 )
2005
24
Profound early-onset neonatal anemia: a case study. ( 12943209 )
2002
25
Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1. ( 11791870 )
2001
26
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. ( 11147059 )
2000
27
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. ( 10612190 )
1999
28
[Recombinant erythropoietin and early preterm neonatal anemia]. ( 10476641 )
1999
29
Management of severe neonatal anemia due to fetomaternal transfusion. ( 10458533 )
1999
30
The nonreactive nonstress test: predictive value for neonatal anemia in the isoimmunized pregnancy. ( 8752240 )
1996
31
Erythropoietin in the pathogenesis and treatment of neonatal anemia. ( 7998075 )
1995
32
Recombinant human erythropoietin in neonatal anemia. ( 8521685 )
1995
33
Neonatal anemia: pathophysiology and treatment. ( 7713595 )
1995
34
Erythropoietin and neonatal anemia. ( 8139633 )
1994
35
Unusual clinical features of neonatal anemia due to fetomaternal transfusion. ( 8333290 )
1993
36
Fetal hemoglobin in neonatal anemia. ( 1702888 )
1991
37
The changing pattern of maternal and neonatal anemia at Udaipur during 2 decades in relation to poverty, parity, prematurity and vegetarianism. ( 2064586 )
1991
38
Management of neonatal anemia in the delivery room. ( 2094675 )
1990
39
Evaluation of a new method for the prevention of neonatal anemia. ( 2704595 )
1989
40
Nuchal cord as a cause of neonatal anemia. ( 4036898 )
1985
41
Nuchal cord as a cause of neonatal anemia. ( 3969987 )
1985
42
Diamond-Blackfan anemia. Neonatal presentation as Rh incompatibility, hemolysis, and active erythropoiesis. ( 4083394 )
1985
43
Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome--a case report. ( 6502441 )
1984
44
Choriocarcinoma with neonatal anemia. ( 584929 )
1977
45
Severe neonatal anemia due to massive transplacental hemorrhage. ( 6021546 )
1967
46
Relation of time of ligation of umbilical cord to neonatal anemia. ( 5183183 )
1967
47
Congenital neonatal anemia in Hanford miniature swine. BNWL-280. ( 5301031 )
1966
48
Relation of maternal fetal hemoglobin and bilirubin to neonatal anemia, type of delivery, and outcome of pregnancy. ( 13977769 )
1963
49
Neonatal anemia due to water-soluble vitamin K analogue: case report. ( 13712478 )
1961
50
Neonatal anemia due to transplacental blood loss; a case report. ( 13661246 )
1959

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 EPO KLF1
2
Show member pathways
10.6 EPO EPOR
3 10.05 EPO EPOR

GO Terms for Neonatal Anemia

Cellular components related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.96 HBA2 HBG1
2 haptoglobin-hemoglobin complex GO:0031838 8.62 HBA2 HBG1

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterooligomerization GO:0051291 9.37 HBA2 HBG1
2 erythrocyte differentiation GO:0030218 9.32 EPO KLF1
3 microtubule-based process GO:0007017 9.26 TUBB2B TUBB3
4 hydrogen peroxide catabolic process GO:0042744 9.16 HBA2 HBG1
5 oxygen transport GO:0015671 8.96 HBA2 HBG1
6 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Molecular functions related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.32 HBA2 HBG1
2 peroxidase activity GO:0004601 9.26 HBA2 HBG1
3 oxygen carrier activity GO:0005344 9.16 HBA2 HBG1
4 organic acid binding GO:0043177 8.96 HBA2 HBG1
5 haptoglobin binding GO:0031720 8.62 HBA2 HBG1

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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