MCID: NNT011
MIFTS: 34

Neonatal Anemia

Categories: Blood diseases

Aliases & Classifications for Neonatal Anemia

MalaCards integrated aliases for Neonatal Anemia:

Name: Neonatal Anemia 12 15
Anemia, Neonatal 45 74
Anemia Neonatal 12 56

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 45 D000751
SNOMED-CT 69 33130007
UMLS 74 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to thalassemia and deficiency anemia. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation and Paxillin-dependent events mediated by a4b1. The drugs Sodium Citrate and Iron have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and pituitary, and related phenotype is mortality/aging.

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 thalassemia 30.2 EPO HBA2
2 deficiency anemia 30.0 EPO EPOR HBA2
3 beta-thalassemia 29.7 EPO HBA2 KLF1
4 anemia of prematurity 29.6 EPO EPOR
5 alpha-thalassemia 29.5 EPO HBA2 KLF1
6 diamond-blackfan anemia 29.3 EPO EPOR KLF1
7 elliptocytosis 3 11.1
8 neonatal autoimmune hemolytic anemia 11.1
9 diabetic autonomic neuropathy 10.2 EPO HBA2
10 arteriovenous fistula 10.2 EPO PCNA
11 splenomegaly 10.2 EPO HBA2
12 acquired polycythemia 10.2 EPO EPOR
13 polycythemia 10.2 EPO EPOR
14 erythrocytosis, familial, 2 10.2 EPO EPOR
15 hemoglobin h disease 10.1 EPO HBA2
16 ewing's family of tumors 10.1 EPO EPOR
17 sickle cell disease 10.1 EPO HBA2
18 erythrocytosis, familial, 1 10.1 EPO EPOR
19 primary polycythemia 10.1 EPO EPOR
20 microcytic anemia 10.1 EPO HBA2
21 hemoglobinopathy 10.0 EPO HBA2 KLF1
22 congenital hemolytic anemia 10.0 EPO HBA2 KLF1
23 erythroleukemia, familial 10.0 EPO EPOR KLF1
24 hemangioblastoma 9.9 EPO EPOR
25 sickle cell anemia 9.9 EPO HBA2
26 fetal hemoglobin quantitative trait locus 1 9.8
27 hemochromatosis, type 1 9.8
28 juvenile hereditary hemochromatosis 9.8
29 ovalocytosis, southeast asian 9.6
30 blood group, junior system 9.6
31 lymphatic malformation 7 9.6
32 hemolytic anemia 9.6
33 thrombocytopenia 9.6
34 vitamin b12 deficiency 9.6
35 placenta praevia 9.6
36 choriocarcinoma 9.6
37 myofibroma 9.6
38 placenta disease 9.6
39 fetal edema 9.6
40 hydrops fetalis 9.6

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

MGI Mouse Phenotypes related to Neonatal Anemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.17 EPO EPOR HBA2 KLF1 L3MBTL1 PCNA

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium Citrate Approved, Investigational Phase 3 68-04-2
2
Iron Approved, Experimental Phase 2, Phase 3,Not Applicable 7439-89-6, 15438-31-0 27284 23925
3
Dalteparin Approved Phase 3 9005-49-6
4
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
5
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
6
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
7
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
8
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
9
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
10 Anticoagulants Phase 3,Phase 2
11 Phosphodiesterase 5 Inhibitors Phase 3
12 Sildenafil Citrate Phase 3 171599-83-0
13 Chelating Agents Phase 3
14 Calcium, Dietary Phase 3
15 Vasodilator Agents Phase 3
16 Phosphodiesterase Inhibitors Phase 3
17 Citrate Phase 3
18 Dextrans Phase 2, Phase 3
19 Epoetin alfa Phase 2, Phase 3 113427-24-0
20 Iron-Dextran Complex Phase 2, Phase 3
21 Hematinics Phase 2, Phase 3
22 Fibrinolytic Agents Phase 3,Not Applicable
23 calcium heparin Phase 3
24 Heparin, Low-Molecular-Weight Phase 3
25 Antimalarials Phase 3
26 Anti-Infective Agents Phase 3
27 Antiparasitic Agents Phase 3
28 Trimethoprim, Sulfamethoxazole Drug Combination Phase 3
29 Antiprotozoal Agents Phase 3
30 Artemisinins Phase 3
31 Artemisinine Phase 3
32 Immunologic Factors Phase 3
33 Immunoglobulins Phase 3
34 Vaccines Phase 3
35 Antibodies Phase 3
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
37
Biotin Approved, Investigational, Nutraceutical Phase 2 58-85-5 171548
38 Micronutrients Phase 2
39 Vitamin B7 Phase 2
40 Vitamins Phase 2
41 Vitamin B Complex Phase 2
42 Folate Phase 2
43 Vitamin B9 Phase 2
44 Nutrients Phase 2
45 Trace Elements Phase 2
46
Lidocaine Approved, Vet_approved 137-58-6 3676
47
Racepinephrine Approved 329-65-7 838
48
Epinephrine Approved, Vet_approved 51-43-4 5816
49
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
50
Histidine Approved, Nutraceutical 71-00-1 6274

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
2 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
3 Effect of Placental Drainage of Fetal Blood at Cesarean Section on the Incidence of Feto-Maternal Transfusion Completed NCT00470899 Phase 3
4 Sildenafil Versus Low Molecular Weight Heparin in Fetal Growth Restriction Treatment Recruiting NCT03230162 Phase 3 Sildenafil;low molecular weight heparin
5 Improving Maternal heAlth by Reducing Malaria in African HIV Women Not yet recruiting NCT03671109 Phase 3 Dihydroartemisinin-piperaquine (DHA-PPQ);Placebo Oral Tablet
6 Clinical Efficacy of Postpartum Immunization of Rh and Coombs Negative Women With Sensitization Risk. Suspended NCT01666249 Phase 3
7 Immediate VS Delayed Cord Clamping on Newborns Unknown status NCT01029496 Phase 1, Phase 2
8 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
9 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
10 Optimized Erythropoietin (EPO) Treatment Active, not recruiting NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
11 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
12 Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia Recruiting NCT03352310 Phase 1
13 Research of Systemic Management for Late Preterm Infants Nutrition in China Unknown status NCT02605577 Not Applicable
14 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852 Not Applicable
15 The Trial of Pessary After Laser for TTTS Unknown status NCT01334489 Not Applicable
16 Milking Versus Delayed Cord Clamping in Full Term Neonates Completed NCT02454101 Not Applicable
17 Identification of Early Predictors of Fetomaternal Hemorrhage Completed NCT01232387
18 Influence of Umbilical Cord Clamping Time in the Newborn Completed NCT03624335 Not Applicable
19 Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome Completed NCT03151915
20 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Completed NCT03449823
21 Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome Completed NCT01622049
22 Alteration of Stool Microbiota in Preterm Infants With Anemia Recruiting NCT03554278
23 Austrian Registry on the Outcome of Monochorionic Pregnancies Recruiting NCT03171909
24 Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome Recruiting NCT02122328 Not Applicable
25 Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial Recruiting NCT03818867 Not Applicable
26 Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise Recruiting NCT03775954
27 Determinants of Neonatal Anemia in Women Carrying Multiples Active, not recruiting NCT01582802
28 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Active, not recruiting NCT01220011 Not Applicable
29 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome Active, not recruiting NCT02249624
30 Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome Active, not recruiting NCT02611856
31 Laser Photocoagulation in Twin to Twin Transfusion Syndrome Enrolling by invitation NCT02506049 Not Applicable
32 Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea Not yet recruiting NCT03462615
33 Implementation of First-trimester Screening and preventiOn of pREeClAmpSia Trial (FORECAST) Not yet recruiting NCT03941886 Not Applicable
34 Supine vs Prone Position at Birth Before Cord Clamping A Randomized Controlled Trial Not yet recruiting NCT03697967 Not Applicable
35 The Validity of Kleinhauer Betke in Women With Known Hemoglobinopathy for Fetal-maternal Hemorrhage Not yet recruiting NCT03591640 Not Applicable

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

42
Placenta, Testes, Pituitary

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show top 50) (show all 54)
# Title Authors Year
1
A Novel Mutation of Glucose Phosphate Isomerase (GPI) Causing Severe Neonatal Anemia Due to GPI Deficiency. ( 30585945 )
2018
2
Epsilon gamma delta beta thalassemia: A rare cause of fetal and neonatal anemia. ( 29162270 )
2018
3
A Solitary Intestinal Myofibroma: A Rare Cause of Neonatal Anemia. ( 29279689 )
2017
4
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. ( 28143845 )
2017
5
Neonatal anemia: Revisiting the enigmatic pyknocyte. ( 28335086 )
2017
6
Management and prevention of neonatal anemia: current evidence and guidelines. ( 24524256 )
2014
7
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. ( 23033916 )
2013
8
Severe neonatal anemia from fetomaternal hemorrhage: report from a multihospital health-care system. ( 23196720 )
2013
9
Imaging diagnosis of neonatal anemia: report of two unusual etiologies. ( 24605254 )
2013
10
A novel epsilon gamma delta beta thalassemia presenting with pregnancy complications and severe neonatal anemia. ( 23206178 )
2013
11
Clinical and research issues in neonatal anemia and thrombocytopenia. ( 22227780 )
2012
12
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. ( 22818543 )
2012
13
Doppler middle cerebral artery peak systolic velocity for diagnosis of neonatal anemia. ( 22922618 )
2012
14
Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia. ( 21388342 )
2011
15
Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. ( 21481087 )
2011
16
Risk factors of neonatal anemia in placenta previa. ( 21960747 )
2011
17
Infantile pyknocytosis: a rare form of neonatal anemia. ( 20684190 )
2010
18
Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). ( 19409822 )
2009
19
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. ( 19371274 )
2009
20
Neonatal anemia. ( 18411074 )
2008
21
Treatment and Prevention of Neonatal Anemia. ( 20209037 )
2008
22
Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. ( 17180133 )
2007
23
Assessment of neonatal anemia. ( 17453046 )
2007
24
Neonatal anemia associated with Southeast Asian ovalocytosis. ( 16207591 )
2005
25
Profound early-onset neonatal anemia: a case study. ( 12943209 )
2002
26
Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1. ( 11791870 )
2001
27
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. ( 11147059 )
2000
28
Management of severe neonatal anemia due to fetomaternal transfusion. ( 10458533 )
1999
29
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. ( 10612190 )
1999
30
[Recombinant erythropoietin and early preterm neonatal anemia]. ( 10476641 )
1999
31
The nonreactive nonstress test: predictive value for neonatal anemia in the isoimmunized pregnancy. ( 8752240 )
1996
32
Neonatal anemia: pathophysiology and treatment. ( 7713595 )
1995
33
Erythropoietin in the pathogenesis and treatment of neonatal anemia. ( 7998075 )
1995
34
Recombinant human erythropoietin in neonatal anemia. ( 8521685 )
1995
35
Erythropoietin and neonatal anemia. ( 8139633 )
1994
36
Unusual clinical features of neonatal anemia due to fetomaternal transfusion. ( 8333290 )
1993
37
Fetal hemoglobin in neonatal anemia. ( 1702888 )
1991
38
The changing pattern of maternal and neonatal anemia at Udaipur during 2 decades in relation to poverty, parity, prematurity and vegetarianism. ( 2064586 )
1991
39
Management of neonatal anemia in the delivery room. ( 2094675 )
1990
40
Evaluation of a new method for the prevention of neonatal anemia. ( 2704595 )
1989
41
Nuchal cord as a cause of neonatal anemia. ( 3969987 )
1985
42
Nuchal cord as a cause of neonatal anemia. ( 4036898 )
1985
43
Diamond-Blackfan anemia. Neonatal presentation as Rh incompatibility, hemolysis, and active erythropoiesis. ( 4083394 )
1985
44
Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome--a case report. ( 6502441 )
1984
45
Choriocarcinoma with neonatal anemia. ( 584929 )
1977
46
Relation of time of ligation of umbilical cord to neonatal anemia. ( 5183183 )
1967
47
Severe neonatal anemia due to massive transplacental hemorrhage. ( 6021546 )
1967
48
Congenital neonatal anemia in Hanford miniature swine. BNWL-280. ( 5301031 )
1966
49
Relation of maternal fetal hemoglobin and bilirubin to neonatal anemia, type of delivery, and outcome of pregnancy. ( 13977769 )
1963
50
Neonatal anemia due to water-soluble vitamin K analogue: case report. ( 13712478 )
1961

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 EPO KLF1
2
Show member pathways
10.6 EPO EPOR
3 10.05 EPO EPOR

GO Terms for Neonatal Anemia

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 erythrocyte differentiation GO:0030218 9.16 EPO KLF1
2 response to dexamethasone GO:0071548 8.96 EPO PCNA
3 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Molecular functions related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 ACCS EPOR L3MBTL1 PCNA

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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