MCID: NNT011
MIFTS: 34

Neonatal Anemia

Categories: Blood diseases

Aliases & Classifications for Neonatal Anemia

MalaCards integrated aliases for Neonatal Anemia:

Name: Neonatal Anemia 12 15
Anemia, Neonatal 44 70
Anemia Neonatal 12 54
Anaemia Neonatal 12
Neonatal Anaemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 44 D000751
SNOMED-CT 67 111468003
UMLS 70 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to anemia of prematurity and blood group incompatibility. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are G-protein signaling_K-RAS regulation pathway and VEGF binds to VEGFR leading to receptor dimerization. The drugs Iron and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 anemia of prematurity 30.3 EPOR EPO
2 blood group incompatibility 30.1 RHD RHCE KEL
3 hemoglobinopathy 30.0 RHCE KLF1 HBA2 EPO
4 polycythemia 29.8 HBA2 EPOR EPO
5 placenta praevia 29.8 PGF PAPPA
6 bilirubin metabolic disorder 29.8 RHD RHCE EPO
7 beta-thalassemia 29.7 RHD KLF1 HBA2 EPOR EPO
8 deficiency anemia 29.7 RHD PKLR KLF1 HBA2 EPOR EPO
9 hemolytic anemia 29.7 RHD RHCE PKLR KLF1 HBA2 EPO
10 hereditary spherocytosis 29.6 RHD PKLR KLF1
11 congenital hemolytic anemia 29.6 PKLR KLF1 HBA2 EPO
12 placenta disease 29.4 PGF PAPPA FLT1
13 alpha-thalassemia 29.4 KLF1 HBA2 EPO
14 lumbosacral lipoma 10.3 EPOR EPO
15 progressive myoclonus epilepsy 9 10.3 EPOR EPO
16 splenic sequestration 10.3 RHCE EPO
17 acquired polycythemia 10.3 EPOR EPO
18 rh deficiency syndrome 10.3 RHD RHCE
19 thalassemia minor 10.2 KLF1 HBA2 EPO
20 hemoglobin h disease 10.2 KLF1 HBA2 EPO
21 rh isoimmunization 10.2 RHD RHCE EPO
22 primary polycythemia 10.2 EPOR EPO
23 acute erythroid leukemia 10.2 KLF1 EPOR EPO
24 primary thrombocytopenia 10.2 RHD RHCE
25 fetal erythroblastosis 10.2 RHD RHCE KEL
26 erythrocytosis, familial, 1 10.2 EPOR EPO
27 otopalatodigital syndrome spectrum disorder 10.2 RHD RHCE KEL
28 melnick-needles syndrome 10.2 RHD RHCE KEL
29 anemia, congenital dyserythropoietic, type iv 10.1 ZNF274 KLF1
30 erythrocytosis, familial, 2 10.1 EPOR EPO
31 cancer-associated retinopathy 10.1 PGF FLT1
32 glutamate-cysteine ligase deficiency 10.1 RHD RHCE PKLR
33 epithelioid hemangioendothelioma 10.1 PGF FLT1
34 sickle cell anemia 10.1 PGF HBA2 EPO
35 blood group, globoside system 10.1 PGF FLT1
36 sickle cell disease 10.1 RHD PGF HBA2 EPO
37 kuhnt-junius degeneration 10.1 PGF FLT1
38 neovascular glaucoma 10.1 PGF FLT1
39 hypertensive encephalopathy 10.0 PGF FLT1 EPO
40 kernicterus 10.0 RHD RHCE
41 orofaciodigital syndrome viii 10.0 RHCE PAPPA LINC01547
42 thalassemia 10.0
43 epiglottis cancer 10.0 EPO ENG
44 congenital dyserythropoietic anemia 10.0 RHD PKLR KLF1 EPO
45 endophthalmitis 10.0 PGF FLT1
46 microvascular complications of diabetes 1 10.0 PGF FLT1 EPO
47 retinal vascular occlusion 10.0 PGF FLT1
48 exudative vitreoretinopathy 1 10.0 PGF FLT1 EPO
49 patau syndrome 9.9 RHD RHCE PGF PAPPA
50 intussusception 9.9 PGF FLT1

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

GenomeRNAi Phenotypes related to Neonatal Anemia according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 9.4 RHCE
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.4 PGF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-133 9.4 RHCE
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.4 SFXN1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.4 PGF
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.4 SFXN1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 9.4 RHCE
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 RHD
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.4 RHCE
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.4 PGF
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 9.4 RHCE
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-82 9.4 SFXN1

MGI Mouse Phenotypes related to Neonatal Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 DNASE2 ENG EPO EPOR FLT1 HBA2
2 homeostasis/metabolism MP:0005376 9.4 DNASE2 ENG EPO EPOR FLT1 HBA2

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3 7439-89-6 23925 29936
2 Hematinics Phase 2, Phase 3
3 Epoetin alfa Phase 2, Phase 3 113427-24-0
4 Dextrans Phase 2, Phase 3
5 Iron-Dextran Complex Phase 2, Phase 3
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
7
Biotin Approved, Investigational, Nutraceutical Phase 2 58-85-5 171548
8 Anticoagulants Phase 2
9 Trace Elements Phase 2
10 Vitamin B9 Phase 2
11 Nutrients Phase 2
12 Folate Phase 2
13 Vitamin B Complex Phase 2
14 Vitamins Phase 2
15 Micronutrients Phase 2
16 Vitamin B7 Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Preterm Infants 401-1250 Grams: Two Multi-Center, Randomized, Double-Masked, Placebo Controlled Studies Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
2 Optimized EPO Treatment of Neonatal Anemia Unknown status NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
3 Red Blood Cell Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
4 Safety and Effectiveness Phase 1 Study of Autologous Umbilical Cord Blood Transfusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
5 Umbilical Cord Blood Mononuclear Cell Bank in Hong Kong and Treatment of Neonatal Cerebral Ischemia and Anemia - Part IV Clinical Trial Unknown status NCT03352310 Phase 1
6 Supine vs Prone Position at Birth Before Cord Clamping A Randomized Controlled Trial Unknown status NCT03697967
7 Identification of Early Predictors of Fetomaternal Hemorrhage And Development Of An Automated Screening Strategy For At-Risk Pregnancies Completed NCT01232387
8 Milking Versus Delayed Cord Clamping in Full Term Neonates Delivered by Elective Cesarean Section A Randomized Controlled Trial Completed NCT02454101
9 Influence of Umbilical Cord Clamping Time in the Newborn, Secondary Neonatal Morbidity and Iron Deposits in the Neonate Completed NCT03624335
10 A Cluster Randomized Trial Comparing a Conservative Management and Primary Laser Surgery Completed NCT01220011
11 Alteration of Stool Microbiota in Preterm Infants Less Than 32 Weeks With Anemia, and Following Blood Transfusion Recruiting NCT03554278

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

40
Placenta, Endothelial, Pituitary, Heart, Liver, Thyroid, Skin

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show top 50) (show all 197)
# Title Authors PMID Year
1
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. 54 61
19371274 2009
2
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. 54 61
11147059 2000
3
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. 61 54
10612190 1999
4
[Recombinant erythropoietin and early preterm neonatal anemia]. 54 61
10476641 1999
5
[Common anemias in neonatology]. 61 54
10067373 1999
6
Recombinant human erythropoietin in neonatal anemia. 61 54
8521685 1995
7
Neonatal anemia: pathophysiology and treatment. 54 61
7713595 1995
8
Erythropoietin in the pathogenesis and treatment of neonatal anemia. 61 54
7998075 1995
9
Erythropoietin and neonatal anemia. 54 61
8139633 1994
10
Southeast Asian Ovalocytosis and Hemoglobinopathies in Newborns: Prevalence, Molecular, and Hematologic Analyses. 61
32815885 2021
11
Multidisciplinary management of anti-PP1Pk or anti-P alloimmunization during pregnancy: A new case with anti-P and a literature review. 61
33811650 2021
12
Defining the functionally sufficient regulatory region and liver-specific roles of the erythropoietin gene by transgene complementation. 61
33465391 2021
13
Erythropoietin therapy in a case of neonatal anemia after exposure to natalizumab throughout pregnancy. 61
33757559 2021
14
Severe neonatal anemia affected by massive fetomaternal hemorrhage: a single-center retrospective observational study. 61
33183095 2020
15
Performance of the Kleihauer Betke test in the prediction of neonatal anemia. 61
33106065 2020
16
Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1). 61
33339573 2020
17
Three non-classical mechanisms for anemic disease of the fetus and newborn, based on maternal anti-Kell, anti-Ge3, anti-M, and anti-Jra cases. 61
32994126 2020
18
The role of recombinant Human erythropoietin in neonatal anemia. 61
31628923 2020
19
Reticulocyte hemoglobin concentration for screening iron deficiency in very low birth weight preterm neonates. 61
32930014 2020
20
Variations in reported outcomes in studies on vasa previa: a systematic review. 61
33345867 2020
21
Reduced fetal movement during pregnancy: Is the Kleihauer-Betke test really useful? 61
32438135 2020
22
Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions. 61
32090604 2020
23
A disadvantage of cesarean section en caul: Umbilical velamentous insertion, a risk factor and proposed mechanism of neonatal anemia. 61
31646709 2020
24
Effect of Delayed Cord Clamping at 30 Seconds and 1 Minute on Neonatal Hematocrit in Term Cesarean Delivery: A Randomized Trial. 61
32607000 2020
25
Prevalence, risk factors, and outcome of hospitalization of neonatal hyperglycemia at a Nigerian health facility. 61
31929210 2020
26
A Novel εγδβ-Thalassemia Deletion Associated with Severe Anemia at Birth and a β-Thalassemia Intermedia Phenotype Later in Life in Three Generations of a Greek Family. 61
31829079 2019
27
Clinical and molecular characterization of novel deletions causing epsilon gamma delta beta thalassemia: Report of two cases. 61
31451289 2019
28
Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens. 61
31340188 2019
29
Presentation of Compound Heterozygous Hemoglobin Constant Spring and Hemoglobin Pakse in Neonates. 61
30615015 2019
30
Harderoporphyria: Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations. 61
30828546 2019
31
Case Report of Anemia Following Fetal-Maternal Hemorrhage. 61
30969944 2019
32
Delayed clamping vs milking of umbilical cord in preterm infants: a randomized controlled trial. 61
30786254 2019
33
[Severe neonatal anemia due to fetomaternal hemorrhage: an ilustrative case]. 61
30869493 2019
34
A Novel Mutation of Glucose Phosphate Isomerase (GPI) Causing Severe Neonatal Anemia Due to GPI Deficiency. 61
30585945 2019
35
Prenatal Diagnosis of Vasa Previa: Outpatient versus Inpatient Management. 61
30130820 2019
36
Successful Management of the Fetal Severe Anemia Associated with Jra Alloimmunization by Intrauterine Transfusion of Jr(a+) Red Blood Cells. 61
30918730 2019
37
In-hospital mortality of very preterm infants in a Tunisian neonatal intensive care unit: Prevalence and risk factors. 61
31131869 2018
38
Association Between Attempted External Cephalic Version and Perinatal Morbidity and Mortality. 61
29995733 2018
39
Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia. 61
29476317 2018
40
Epsilon gamma delta beta thalassemia: A rare cause of fetal and neonatal anemia. 61
29162270 2018
41
Adverse effects in children exposed to maternal HIV and antiretroviral therapy during pregnancy in Brazil: a cohort study. 61
29747664 2018
42
Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study. 61
29562891 2018
43
Body Growth and Rapid Hematological Development Support Breath Hold of Baby Belugas (Delphinapterus leucas) during Subice Transit. 61
29125799 2018
44
Type I interferon-mediated autoinflammation due to DNase II deficiency. 61
29259162 2017
45
[Trauma and pregnancy: Is the Kleihauer-Betke test really useful?] 61
28967599 2017
46
A Solitary Intestinal Myofibroma: A Rare Cause of Neonatal Anemia. 61
29279689 2017
47
Neonatal anemia: Revisiting the enigmatic pyknocyte. 61
28335086 2017
48
Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing. 61
27882484 2017
49
Biochemical analysis of intraplacental choriocarcinoma and fetomaternal transfusion. 61
28168818 2017
50
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. 61
28143845 2017

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.39 EPOR EPO
2
Show member pathways
9.83 PGF FLT1

GO Terms for Neonatal Anemia

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.61 PGF FLT1 ENG
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.54 FLT1 EPOR EPO
3 response to hypoxia GO:0001666 9.46 PKLR PGF EPO ENG
4 vascular endothelial growth factor signaling pathway GO:0038084 9.4 PGF FLT1
5 ammonium transmembrane transport GO:0072488 9.32 RHD RHCE
6 ammonium transport GO:0015696 9.26 RHD RHCE
7 erythrocyte differentiation GO:0030218 9.13 KLF1 EPO DNASE2
8 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPOR EPO

Molecular functions related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ammonium transmembrane transporter activity GO:0008519 8.62 RHD RHCE

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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