MCID: NNT005
MIFTS: 31

Neonatal Candidiasis

Categories: Fetal diseases, Infectious diseases

Aliases & Classifications for Neonatal Candidiasis

MalaCards integrated aliases for Neonatal Candidiasis:

Name: Neonatal Candidiasis 12 15 70 32
Neonatal Candida Infection 12
Neonatal Monilia Infection 12
Neonatal Moniliasis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9577
ICD9CM 34 771.7
NCIt 50 C116810
SNOMED-CT 67 3973009
ICD10 32 P37.5
UMLS 70 C0276682

Summaries for Neonatal Candidiasis

Disease Ontology : 12 A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.

MalaCards based summary : Neonatal Candidiasis, also known as neonatal candida infection, is related to oral candidiasis and candidiasis. An important gene associated with Neonatal Candidiasis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are NF-kappaB Signaling and CLEC7A (Dectin-1) signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye and skin.

Related Diseases for Neonatal Candidiasis

Diseases related to Neonatal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 oral candidiasis 29.3 CLEC7A CLEC6A CARD9
2 candidiasis 10.7
3 candidal paronychia 10.1 LCE4A C1orf68
4 meningitis 10.1
5 penicilliosis 10.0 CLEC7A CARD9
6 candidiasis, familial, 2 10.0 CLEC7A CARD9
7 exudative vitreoretinopathy 1 10.0
8 enterocolitis 10.0
9 bacterial sepsis 10.0
10 bacterial infectious disease 10.0
11 endophthalmitis 10.0
12 perinatal necrotizing enterocolitis 10.0
13 adenoiditis 10.0 CLEC7A CARD9
14 esophageal candidiasis 9.9 CLEC7A CARD9
15 filarial elephantiasis 9.9 TLR6 MT-CO1
16 sporotrichosis 9.9 CLEC7A CARD9
17 neuroaspergillosis 9.9 CLEC7A CARD9
18 hyper ige recurrent infection syndrome 1 9.9 CLEC7A CARD9
19 pneumocystosis 9.9 CLEC7A CARD9
20 disease by infectious agent 9.8
21 obstructive nephropathy 9.8
22 meningoencephalitis 9.8
23 pre-eclampsia 9.8
24 eclampsia 9.8
25 eye disease 9.8
26 peritonitis 9.8
27 cataract 9.8
28 bronchopulmonary dysplasia 9.8
29 candida glabrata 9.8
30 vulvovaginal candidiasis 9.8 CLEC7A CARD9
31 tinea cruris 9.8 CLEC6A CARD9
32 pityriasis versicolor 9.8 CLEC7A CLEC6A
33 superficial mycosis 9.7 CLEC7A CLEC6A
34 vaginal disease 9.7 CLEC7A CARD9
35 corneal ulcer 9.7 CLEC7A CLEC6A
36 autoimmune polyendocrine syndrome type 1 9.6 CLEC7A CARD9
37 tinea profunda 9.6 CLEC7A CLEC6A CARD9
38 trichosporonosis 9.6 CLEC7A CLEC6A CARD9
39 tinea capitis 9.6 CLEC7A CLEC6A CARD9
40 phaeohyphomycosis 9.6 CLEC7A CLEC6A CARD9
41 tinea pedis 9.6 CLEC7A CLEC6A CARD9
42 cutaneous candidiasis 9.6 CLEC7A CLEC6A CARD9
43 tinea corporis 9.6 CLEC7A CLEC6A CARD9
44 subcutaneous mycosis 9.6 CLEC7A CLEC6A CARD9
45 blastomycosis 9.6 CLEC7A CLEC6A CARD9
46 chromoblastomycosis 9.6 CLEC7A CLEC6A CARD9
47 mucormycosis 9.6 CLEC7A CLEC6A CARD9
48 dermatophytosis 9.6 CLEC7A CLEC6A CARD9
49 coccidioidomycosis 9.6 CLEC7A CLEC6A CARD9
50 primary systemic mycosis 9.6 CLEC7A CLEC6A CARD9

Graphical network of the top 20 diseases related to Neonatal Candidiasis:



Diseases related to Neonatal Candidiasis

Symptoms & Phenotypes for Neonatal Candidiasis

Drugs & Therapeutics for Neonatal Candidiasis

Drugs for Neonatal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
4
Micafungin Approved, Investigational Phase 3 235114-32-6 3081921 477468
5
deoxycholic acid Approved Phase 3 83-44-3 222528
6 Liposomal amphotericin B Phase 3
7 Gastrointestinal Agents Phase 3
8 Antiparasitic Agents Phase 3
9 Amphotericin B, deoxycholate drug combination Phase 3
10 Antiprotozoal Agents Phase 3
11 Antifungal Agents Phase 3
12 Anti-Bacterial Agents Phase 3
13 Anti-Infective Agents Phase 3
14 Amebicides Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 3, Randomized, Double-Blind, Multi-Center Study to Compare the Efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for the Treatment of Neonatal Candidiasis Terminated NCT00815516 Phase 3 micafungin;amphotericin B deoxycholate

Search NIH Clinical Center for Neonatal Candidiasis

Genetic Tests for Neonatal Candidiasis

Anatomical Context for Neonatal Candidiasis

MalaCards organs/tissues related to Neonatal Candidiasis:

40
Eye, Skin

Publications for Neonatal Candidiasis

Articles related to Neonatal Candidiasis:

(show top 50) (show all 91)
# Title Authors PMID Year
1
A Regulatory Review Approach for Evaluation of Micafungin for Treatment of Neonatal Candidiasis. 61
33458754 2021
2
Vaginal yeast colonisation: From a potential harmless condition to clinical implications and management approaches-A literature review. 61
31038771 2019
3
Maternal pregnancy-induced hypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study. 61
30910150 2019
4
Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. 61
29369937 2018
5
Spectrum of candidal species isolated from neonates admitted in an Intensive Care Unit of teaching hospital of Kashmir, North India. 61
30078958 2018
6
Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials. 61
29762386 2018
7
Comprehensive drug utilization review in neonates: liposomal amphotericin B. 61
29365355 2018
8
Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome. 61
28077516 2017
9
Common Skin Conditions in Children: Neonatal Skin Lesions. 61
28196316 2017
10
Candida parapsilosis Secreted Lipase as an Important Virulence Factor. 61
27526931 2017
11
Fatal Neonatal Peritoneal Candidiasis Mimicking Mucormycosis-A Case Report and Review of Literature. 61
27185733 2016
12
Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface. 61
26779297 2015
13
Clinical spectrum, management and outcome of neonatal candidiasis. 61
26564294 2015
14
Advances in the treatment of invasive neonatal candidiasis. 61
25842986 2015
15
Neonatal candidiasis: diagnosis, prevention, and treatment. 61
25129318 2014
16
Phenotypic consequences of LYS4 gene disruption in Candida albicans. 61
24898203 2014
17
The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils. 61
23279221 2013
18
Time to initiation of antifungal therapy for neonatal candidiasis. 61
23507285 2013
19
Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. 61
22982980 2012
20
Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. 61
22504098 2012
21
Congenital cutaneous candidiasis in two full-term infants. 61
21906141 2012
22
Neonatal candidiasis: results of an 8 year study. 61
22320707 2012
23
Strategies for the prevention of neonatal candidiasis. 61
22503254 2012
24
The use of antifungal therapy in neonatal intensive care. 61
22341539 2012
25
Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight. 61
22333013 2012
26
Incidence of vesicobullous and erosive disorders of neonates. 61
22408704 2011
27
Incidence of Vesicobullous and Erosive Disorders of Neonates: Where and How Much to Worry? 61
22037857 2011
28
A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. 61
21667319 2011
29
Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. 61
21518846 2011
30
Clinical spectrum and outcomes of neonatal candidiasis in a tertiary care hospital in Karachi, Pakistan. 61
21444991 2011
31
Congenital cutaneous candidiasis: a rare and unpredictable disease. 61
21572803 2011
32
Outcomes of neonatal candidiasis: the impact of delayed initiation of antifungal therapy. 61
22121380 2011
33
Clinical microbiology of neonatal candidiasis in Hungary. 61
21183426 2010
34
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. 61
20876174 2010
35
Challenging issues in neonatal candidiasis. 61
20513206 2010
36
Outbreak of Candida parapsilosis in a neonatal intensive care unit: a health care workers source. 61
19957192 2010
37
Recent Advances in the Detection of Neonatal Candidiasis. 61
20454602 2010
38
Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? 61
20204759 2010
39
A clinical review of echinocandins in pediatric patients. 61
20009006 2010
40
Neonatal candidaemia in Kuwait: a 12-year study of risk factors, species spectrum and antifungal susceptibility. 61
18983425 2009
41
Neonatal liver abscesses due to Candida infection effectively treated with caspofungin. 61
19187395 2009
42
[Neonatal candidiasis: therapeutic options]. 61
19536371 2008
43
Antifungal prophylaxis for the prevention of neonatal candidiasis? 61
18363952 2008
44
Antifungal therapy for neonatal candidiasis. 61
17975409 2007
45
Candida isolated from vaginal mucosa of mothers and oral mucosa of neonates: occurrence and biotypes concordance. 61
17596793 2007
46
Outcomes attributable to neonatal candidiasis. 61
17407037 2007
47
Neonatal invasive candidiasis. 61
17093376 2006
48
Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. 61
16982807 2006
49
Fluconazole for the management of invasive candidiasis: where do we stand after 15 years? 61
16449304 2006
50
Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. 61
16396864 2006

Variations for Neonatal Candidiasis

Expression for Neonatal Candidiasis

Search GEO for disease gene expression data for Neonatal Candidiasis.

Pathways for Neonatal Candidiasis

Pathways related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 TLR6 LGALS3 CARD9
2
Show member pathways
11.74 CLEC7A CLEC6A CARD9
3 11.39 TLR6 CLEC7A CARD9
4 11.25 TLR6 CLEC7A
5
Show member pathways
11.04 CLEC7A CLEC6A CARD9

GO Terms for Neonatal Candidiasis

Biological processes related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.5 TLR6 CLEC6A CARD9
2 positive regulation of tumor necrosis factor production GO:0032760 9.48 CLEC7A CARD9
3 positive regulation of protein complex assembly GO:0031334 9.46 LGALS3 CLEC7A
4 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.43 CLEC7A CARD9
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.4 TLR6 CLEC7A
6 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.37 TLR6 CLEC7A
7 immune system process GO:0002376 9.35 TLR6 LGALS3 CLEC7A CLEC6A CARD9
8 positive regulation of interleukin-6 production GO:0032755 9.33 TLR6 CLEC7A CARD9
9 positive regulation of stress-activated MAPK cascade GO:0032874 9.26 CLEC7A CARD9
10 innate immune response GO:0045087 9.02 TLR6 LGALS3 CLEC7A CLEC6A CARD9

Molecular functions related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.8 LGALS3 CLEC7A CLEC6A

Sources for Neonatal Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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