MCID: NNT005
MIFTS: 32

Neonatal Candidiasis

Categories: Fetal diseases, Infectious diseases

Aliases & Classifications for Neonatal Candidiasis

MalaCards integrated aliases for Neonatal Candidiasis:

Name: Neonatal Candidiasis 12 15 73
Neonatal Candida Infection 12
Neonatal Monilia Infection 12
Neonatal Moniliasis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9577
ICD10 33 P37.5
ICD9CM 35 771.7
NCIt 50 C116810
SNOMED-CT 68 3973009
UMLS 73 C0276682

Summaries for Neonatal Candidiasis

Disease Ontology : 12 A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.

MalaCards based summary : Neonatal Candidiasis, also known as neonatal candida infection, is related to candidiasis and fungal esophagitis. An important gene associated with Neonatal Candidiasis is AVPR2 (Arginine Vasopressin Receptor 2). The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include colon and skin.

Related Diseases for Neonatal Candidiasis

Diseases related to Neonatal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 candidiasis 10.6
2 fungal esophagitis 9.9 ATP12A ATP4A
3 diclofenac allergy 9.9 ATP12A ATP4A
4 gastroduodenal crohn's disease 9.9 ATP12A ATP4A
5 photoallergic dermatitis 9.9 ATP12A ATP4A
6 squamous papillomatosis 9.9 ATP12A ATP4A
7 toxic megacolon 9.9 ATP12A ATP4A
8 meningitis 9.9
9 aspiration pneumonitis 9.9 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 9.9 ATP12A ATP4A
11 gastric antral vascular ectasia 9.9 ATP12A ATP4A
12 granulomatous gastritis 9.9 ATP12A ATP4A
13 esophageal candidiasis 9.9 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 9.9 ATP12A ATP4A
15 acute laryngitis 9.9 ATP12A ATP4A
16 laryngitis 9.9 ATP12A ATP4A
17 duodenitis 9.9 ATP12A ATP4A
18 rumination disorder 9.9 ATP12A ATP4A
19 active peptic ulcer disease 9.9 ATP12A ATP4A
20 congenital disorder of deglycosylation 9.9 ATP12A ATP4A
21 bladder calculus 9.9 ATP12A ATP4A
22 ischemic neuropathy 9.9 ATP12A ATP4A
23 bile reflux 9.9 ATP12A ATP4A
24 capillary disease 9.9 ATP12A ATP4A
25 peptic esophagitis 9.9 ATP12A ATP4A
26 dyskinesia of esophagus 9.9 ATP12A ATP4A
27 hernia, hiatus 9.9 ATP12A ATP4A
28 anismus 9.9 ATP12A ATP4A
29 postsurgical hypothyroidism 9.9 ATP12A ATP4A
30 lymphocytic colitis 9.9 ATP12A ATP4A
31 esophageal atresia/tracheoesophageal fistula 9.9 ATP12A ATP4A
32 clostridium difficile colitis 9.9 ATP12A ATP4A
33 diarrhea 1, secretory chloride, congenital 9.9 ATP12A ATP4A
34 microscopic colitis 9.9 ATP12A ATP4A
35 laryngeal tuberculosis 9.9 ATP12A ATP4A
36 chronic laryngitis 9.9 ATP12A ATP4A
37 eosinophilic gastritis 9.9 ATP12A ATP4A
38 esophagus adenocarcinoma 9.9 ATP12A ATP4A
39 chronic intestinal vascular insufficiency 9.9 ATP12A ATP4A
40 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9 ATP12A ATP4A
41 jejunoileitis 9.9 ATP12A ATP4A
42 pancreatic steatorrhea 9.9 ATP12A ATP4A
43 esophageal varix 9.9 ATP12A ATP4A
44 superior mesenteric artery syndrome 9.9 ATP12A ATP4A
45 duodenal disease 9.9 ATP12A ATP4A
46 gastric lymphoma 9.9 ATP12A ATP4A
47 lower urinary tract calculus 9.9 ATP12A ATP4A
48 myopathy, x-linked, with excessive autophagy 9.9 ATP12A ATP4A
49 aspiration pneumonia 9.9 ATP12A ATP4A
50 blind loop syndrome 9.9 ATP12A ATP4A

Graphical network of the top 20 diseases related to Neonatal Candidiasis:



Diseases related to Neonatal Candidiasis

Symptoms & Phenotypes for Neonatal Candidiasis

Drugs & Therapeutics for Neonatal Candidiasis

Drugs for Neonatal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 3 22916-47-8 4189
3
Micafungin Approved, Investigational Phase 2, Phase 3,Phase 3 235114-32-6 3081921 477468
4
deoxycholic acid Approved Phase 3 83-44-3 222528
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
6 Cytochrome P-450 CYP2C19 Inhibitors Phase 2, Phase 3
7 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
8 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
9 Anti-Infective Agents Phase 2, Phase 3,Phase 3
10 Echinocandins Phase 2, Phase 3,Phase 3
11 Steroid Synthesis Inhibitors Phase 2, Phase 3
12 Hormone Antagonists Phase 2, Phase 3
13 Hormones Phase 2, Phase 3
14 Antifungal Agents Phase 2, Phase 3,Phase 3
15 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
17 Antiprotozoal Agents Phase 3
18 Gastrointestinal Agents Phase 3
19 Antiparasitic Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Cholagogues and Choleretics Phase 3
22 Liposomal amphotericin B Phase 3
23 Amphotericin B, deoxycholate drug combination Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluconazole Versus Micafungin in Neonates With Candidiasis Unknown status NCT02145832 Phase 2, Phase 3 Fluconazole;Micafungin
2 Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis Terminated NCT00815516 Phase 3 micafungin;amphotericin B deoxycholate

Search NIH Clinical Center for Neonatal Candidiasis

Genetic Tests for Neonatal Candidiasis

Anatomical Context for Neonatal Candidiasis

MalaCards organs/tissues related to Neonatal Candidiasis:

41
Colon, Skin

Publications for Neonatal Candidiasis

Articles related to Neonatal Candidiasis:

(show top 50) (show all 51)
# Title Authors Year
1
Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. ( 29369937 )
2018
2
Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials. ( 29762386 )
2018
3
Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface. ( 26779297 )
2015
4
Advances in the treatment of invasive neonatal candidiasis. ( 25842986 )
2015
5
Clinical spectrum, management and outcome of neonatal candidiasis. ( 26564294 )
2015
6
Neonatal candidiasis: diagnosis, prevention, and treatment. ( 25129318 )
2014
7
Time to initiation of antifungal therapy for neonatal candidiasis. ( 23507285 )
2013
8
Strategies for the prevention of neonatal candidiasis. ( 22503254 )
2012
9
Neonatal candidiasis: results of an 8 year study. ( 22320707 )
2012
10
Outcomes of neonatal candidiasis: the impact of delayed initiation of antifungal therapy. ( 22121380 )
2011
11
A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. ( 21667319 )
2011
12
Clinical spectrum and outcomes of neonatal candidiasis in a tertiary care hospital in Karachi, Pakistan. ( 21444991 )
2011
13
Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? ( 20204759 )
2010
14
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. ( 20876174 )
2010
15
Recent Advances in the Detection of Neonatal Candidiasis. ( 20454602 )
2010
16
Challenging issues in neonatal candidiasis. ( 20513206 )
2010
17
Clinical microbiology of neonatal candidiasis in Hungary. ( 21183426 )
2010
18
Antifungal prophylaxis for the prevention of neonatal candidiasis? ( 18363952 )
2008
19
Outcomes attributable to neonatal candidiasis. ( 17407037 )
2007
20
Antifungal therapy for neonatal candidiasis. ( 17975409 )
2007
21
Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. ( 16982807 )
2006
22
Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. ( 16396864 )
2006
23
Neonatal candidiasis. ( 16102651 )
2005
24
Survey of neonatal candidiasis in Greece. ( 16283219 )
2005
25
Neonatal candidiasis: prophylaxis and treatment. ( 16086651 )
2005
26
Neonatal candidiasis in Venezuela: clinical and epidemiological aspects. ( 17061542 )
2005
27
Nosocomial neonatal candidiasis. ( 16148852 )
2005
28
Treatment of neonatal candidiasis with liposomal amphotericin B. ( 15181316 )
2004
29
Antifungals in systemic neonatal candidiasis. ( 15101785 )
2004
30
Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates. ( 15605181 )
2004
31
Treatment of neonatal candidiasis with liposomal amphotericin B(L-AMP-LRC-1): phase II study. ( 12824664 )
2003
32
Antifungal pharmacotherapy for neonatal candidiasis. ( 14626500 )
2003
33
Neonatal candidiasis: ophthalmologic infection. ( 14626504 )
2003
34
Colonization and epithelial adhesion in the pathogenesis of neonatal candidiasis. ( 14626499 )
2003
35
Invasive neonatal candidiasis: an overview. ( 14626498 )
2003
36
Liposomal amphotericin B (AmBisome) in the treatment of neonatal candidiasis in very low birth weight infants. ( 10961528 )
2000
37
Persistently positive cultures and outcome in invasive neonatal candidiasis. ( 11001103 )
2000
38
Management of neonatal candidiasis. Neonatal Candidiasis Study Group. ( 9849983 )
1998
39
Use of new nephrostomy catheter for treatment of renal neonatal candidiasis. ( 9412811 )
1997
40
Treatment of systemic neonatal candidiasis with fluconazole. ( 8655216 )
1995
41
Neonatal candidiasis associated with meningitis and endophthalmitis. ( 8091973 )
1994
42
Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection. ( 1741204 )
1992
43
Neonatal candidiasis: the current challenge. ( 1879108 )
1991
44
Systemic neonatal candidiasis. ( 1853494 )
1991
45
Autoinoculated palmar pustules in neonatal candidiasis. ( 2798259 )
1989
46
Neonatal candidiasis: renal and pulmonary manifestations. ( 6779526 )
1980
47
Neonatal candidiasis, meningitis, and arthritis: observations and a review of the literature. ( 5067817 )
1972
48
Neonatal candidiasis. ( 5889834 )
1965
49
The effect of nystatin (mycostatin) on neonatal candidiasis (thrush): a method of eradicating thrush from hospital nurseries. ( 13608364 )
1958
50
Incidence and pathogenesis of neonatal candidiasis. ( 13542086 )
1958

Variations for Neonatal Candidiasis

Expression for Neonatal Candidiasis

Search GEO for disease gene expression data for Neonatal Candidiasis.

Pathways for Neonatal Candidiasis

GO Terms for Neonatal Candidiasis

Biological processes related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.46 ATP12A ATP4A
2 sodium ion transport GO:0006814 9.43 ATP12A ATP4A
3 potassium ion import across plasma membrane GO:1990573 9.4 ATP12A ATP4A
4 potassium ion import GO:0010107 9.37 ATP12A ATP4A
5 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
6 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
8 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Neonatal Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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