MCID: NNT005
MIFTS: 32

Neonatal Candidiasis

Categories: Fetal diseases, Infectious diseases

Aliases & Classifications for Neonatal Candidiasis

MalaCards integrated aliases for Neonatal Candidiasis:

Name: Neonatal Candidiasis 12 15 74
Neonatal Candida Infection 12
Neonatal Monilia Infection 12
Neonatal Moniliasis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9577
ICD9CM 36 771.7
NCIt 51 C116810
SNOMED-CT 69 3973009
ICD10 34 P37.5
UMLS 74 C0276682

Summaries for Neonatal Candidiasis

Disease Ontology : 12 A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.

MalaCards based summary : Neonatal Candidiasis, also known as neonatal candida infection, is related to candidiasis and meningitis. An important gene associated with Neonatal Candidiasis is AVPR2 (Arginine Vasopressin Receptor 2). The drugs Micafungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include colon and skin.

Related Diseases for Neonatal Candidiasis

Diseases related to Neonatal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 candidiasis 10.7
2 meningitis 9.9
3 fungal esophagitis 9.9 ATP12A ATP4A
4 diclofenac allergy 9.9 ATP12A ATP4A
5 gastroduodenal crohn's disease 9.9 ATP12A ATP4A
6 photoallergic dermatitis 9.9 ATP12A ATP4A
7 squamous papillomatosis 9.9 ATP12A ATP4A
8 toxic megacolon 9.9 ATP12A ATP4A
9 aspiration pneumonitis 9.9 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 9.9 ATP12A ATP4A
11 gastric antral vascular ectasia 9.9 ATP12A ATP4A
12 granulomatous gastritis 9.9 ATP12A ATP4A
13 esophageal candidiasis 9.9 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 9.9 ATP12A ATP4A
15 acute laryngitis 9.9 ATP12A ATP4A
16 laryngitis 9.9 ATP12A ATP4A
17 duodenitis 9.9 ATP12A ATP4A
18 rumination disorder 9.9 ATP12A ATP4A
19 active peptic ulcer disease 9.9 ATP12A ATP4A
20 congenital disorder of deglycosylation 9.9 ATP12A ATP4A
21 bladder calculus 9.9 ATP12A ATP4A
22 ischemic neuropathy 9.9 ATP12A ATP4A
23 bile reflux 9.9 ATP12A ATP4A
24 capillary disease 9.9 ATP12A ATP4A
25 peptic esophagitis 9.9 ATP12A ATP4A
26 dyskinesia of esophagus 9.9 ATP12A ATP4A
27 hernia, hiatus 9.9 ATP12A ATP4A
28 anismus 9.9 ATP12A ATP4A
29 postsurgical hypothyroidism 9.9 ATP12A ATP4A
30 lymphocytic colitis 9.9 ATP12A ATP4A
31 esophageal atresia/tracheoesophageal fistula 9.9 ATP12A ATP4A
32 clostridium difficile colitis 9.9 ATP12A ATP4A
33 diarrhea 1, secretory chloride, congenital 9.8 ATP12A ATP4A
34 esophagitis, eosinophilic, 1 9.8 ATP12A ATP4A
35 microscopic colitis 9.8 ATP12A ATP4A
36 laryngeal tuberculosis 9.8 ATP12A ATP4A
37 chronic laryngitis 9.8 ATP12A ATP4A
38 eosinophilic gastritis 9.8 ATP12A ATP4A
39 esophagus adenocarcinoma 9.8 ATP12A ATP4A
40 chronic intestinal vascular insufficiency 9.8 ATP12A ATP4A
41 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP12A ATP4A
42 jejunoileitis 9.8 ATP12A ATP4A
43 pancreatic steatorrhea 9.8 ATP12A ATP4A
44 esophageal varix 9.8 ATP12A ATP4A
45 superior mesenteric artery syndrome 9.8 ATP12A ATP4A
46 gastric lymphoma 9.8 ATP12A ATP4A
47 lower urinary tract calculus 9.8 ATP12A ATP4A
48 myopathy, x-linked, with excessive autophagy 9.8 ATP12A ATP4A
49 aspiration pneumonia 9.8 ATP12A ATP4A
50 hypertension, essential 9.8

Graphical network of the top 20 diseases related to Neonatal Candidiasis:



Diseases related to Neonatal Candidiasis

Symptoms & Phenotypes for Neonatal Candidiasis

Drugs & Therapeutics for Neonatal Candidiasis

Drugs for Neonatal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Micafungin Approved, Investigational Phase 2, Phase 3,Phase 3 235114-32-6 477468 3081921
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 3 22916-47-8 4189
3
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
4
deoxycholic acid Approved Phase 3 83-44-3 222528
5
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
6 Hormone Antagonists Phase 2, Phase 3
7 Steroid Synthesis Inhibitors Phase 2, Phase 3
8 Cytochrome P-450 CYP2C19 Inhibitors Phase 2, Phase 3
9 Hormones Phase 2, Phase 3
10 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
11 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
12 Anti-Infective Agents Phase 2, Phase 3,Phase 3
13 Antifungal Agents Phase 2, Phase 3,Phase 3
14 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
16 Antiparasitic Agents Phase 3
17 Liposomal amphotericin B Phase 3
18 Gastrointestinal Agents Phase 3
19 Antiprotozoal Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Cholagogues and Choleretics Phase 3
22 Amphotericin B, deoxycholate drug combination Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluconazole Versus Micafungin in Neonates With Candidiasis Unknown status NCT02145832 Phase 2, Phase 3 Fluconazole;Micafungin
2 Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis Terminated NCT00815516 Phase 3 micafungin;amphotericin B deoxycholate

Search NIH Clinical Center for Neonatal Candidiasis

Genetic Tests for Neonatal Candidiasis

Anatomical Context for Neonatal Candidiasis

MalaCards organs/tissues related to Neonatal Candidiasis:

42
Colon, Skin

Publications for Neonatal Candidiasis

Articles related to Neonatal Candidiasis:

(show top 50) (show all 53)
# Title Authors Year
1
Maternal pregnancy-induced hypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study. ( 30910150 )
2019
2
Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials. ( 29762386 )
2018
3
Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. ( 29369937 )
2018
4
Clinical spectrum, management and outcome of neonatal candidiasis. ( 26564294 )
2015
5
Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface. ( 26779297 )
2015
6
Advances in the treatment of invasive neonatal candidiasis. ( 25842986 )
2015
7
Neonatal candidiasis: diagnosis, prevention, and treatment. ( 25129318 )
2014
8
Time to initiation of antifungal therapy for neonatal candidiasis. ( 23507285 )
2013
9
Neonatal candidiasis: results of an 8 year study. ( 22320707 )
2012
10
Strategies for the prevention of neonatal candidiasis. ( 22503254 )
2012
11
Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. ( 22504098 )
2012
12
Outcomes of neonatal candidiasis: the impact of delayed initiation of antifungal therapy. ( 22121380 )
2011
13
Clinical spectrum and outcomes of neonatal candidiasis in a tertiary care hospital in Karachi, Pakistan. ( 21444991 )
2011
14
A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. ( 21667319 )
2011
15
Clinical microbiology of neonatal candidiasis in Hungary. ( 21183426 )
2010
16
Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? ( 20204759 )
2010
17
Recent Advances in the Detection of Neonatal Candidiasis. ( 20454602 )
2010
18
Challenging issues in neonatal candidiasis. ( 20513206 )
2010
19
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. ( 20876174 )
2010
20
Antifungal prophylaxis for the prevention of neonatal candidiasis? ( 18363952 )
2008
21
Antifungal therapy for neonatal candidiasis. ( 17975409 )
2007
22
Outcomes attributable to neonatal candidiasis. ( 17407037 )
2007
23
Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. ( 16982807 )
2006
24
Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. ( 16396864 )
2006
25
Neonatal candidiasis in Venezuela: clinical and epidemiological aspects. ( 17061542 )
2005
26
Nosocomial neonatal candidiasis. ( 16148852 )
2005
27
Survey of neonatal candidiasis in Greece. ( 16283219 )
2005
28
Neonatal candidiasis: prophylaxis and treatment. ( 16086651 )
2005
29
Neonatal candidiasis. ( 16102651 )
2005
30
Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates. ( 15605181 )
2004
31
Antifungals in systemic neonatal candidiasis. ( 15101785 )
2004
32
Treatment of neonatal candidiasis with liposomal amphotericin B. ( 15181316 )
2004
33
Treatment of neonatal candidiasis with liposomal amphotericin B(L-AMP-LRC-1): phase II study. ( 12824664 )
2003
34
Invasive neonatal candidiasis: an overview. ( 14626498 )
2003
35
Colonization and epithelial adhesion in the pathogenesis of neonatal candidiasis. ( 14626499 )
2003
36
Antifungal pharmacotherapy for neonatal candidiasis. ( 14626500 )
2003
37
Neonatal candidiasis: ophthalmologic infection. ( 14626504 )
2003
38
Liposomal amphotericin B (AmBisome) in the treatment of neonatal candidiasis in very low birth weight infants. ( 10961528 )
2000
39
Persistently positive cultures and outcome in invasive neonatal candidiasis. ( 11001103 )
2000
40
Management of neonatal candidiasis. Neonatal Candidiasis Study Group. ( 9849983 )
1998
41
Use of new nephrostomy catheter for treatment of renal neonatal candidiasis. ( 9412811 )
1997
42
Treatment of systemic neonatal candidiasis with fluconazole. ( 8655216 )
1995
43
Neonatal candidiasis associated with meningitis and endophthalmitis. ( 8091973 )
1994
44
Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection. ( 1741204 )
1992
45
Systemic neonatal candidiasis. ( 1853494 )
1991
46
Neonatal candidiasis: the current challenge. ( 1879108 )
1991
47
Autoinoculated palmar pustules in neonatal candidiasis. ( 2798259 )
1989
48
Neonatal candidiasis: renal and pulmonary manifestations. ( 6779526 )
1980
49
Neonatal candidiasis, meningitis, and arthritis: observations and a review of the literature. ( 5067817 )
1972
50
Neonatal candidiasis. ( 5889834 )
1965

Variations for Neonatal Candidiasis

Expression for Neonatal Candidiasis

Search GEO for disease gene expression data for Neonatal Candidiasis.

Pathways for Neonatal Candidiasis

GO Terms for Neonatal Candidiasis

Biological processes related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.4 ATP12A ATP4A
2 potassium ion import across plasma membrane GO:1990573 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Neonatal Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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