MCID: NNT005
MIFTS: 27

Neonatal Candidiasis

Categories: Fetal diseases, Infectious diseases

Aliases & Classifications for Neonatal Candidiasis

MalaCards integrated aliases for Neonatal Candidiasis:

Name: Neonatal Candidiasis 12 15 71 32
Neonatal Candida Infection 12
Neonatal Monilia Infection 12
Neonatal Moniliasis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9577
ICD9CM 34 771.7
NCIt 49 C116810
SNOMED-CT 67 3973009
ICD10 32 P37.5
UMLS 71 C0276682

Summaries for Neonatal Candidiasis

Disease Ontology : 12 A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.

MalaCards based summary : Neonatal Candidiasis, also known as neonatal candida infection, is related to candidiasis and meningitis. An important gene associated with Neonatal Candidiasis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I). The drugs Fluconazole and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and liver.

Related Diseases for Neonatal Candidiasis

Diseases related to Neonatal Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 candidiasis 10.7
2 meningitis 10.0
3 candidal paronychia 10.0 LCE4A C1orf68
4 dientamoebiasis 10.0 MT-CO1 ALLC
5 exudative vitreoretinopathy 1 9.9
6 enterocolitis 9.9
7 bacterial sepsis 9.9
8 bacterial infectious disease 9.9
9 oral candidiasis 9.9
10 endophthalmitis 9.9
11 perinatal necrotizing enterocolitis 9.9
12 pre-eclampsia 9.8
13 peritonitis 9.8
14 candida glabrata 9.8
15 bronchopulmonary dysplasia 9.8
16 cataract 9.8
17 eye disease 9.8
18 eclampsia 9.8
19 meningoencephalitis 9.8
20 obstructive nephropathy 9.8
21 denture stomatitis 9.8 CLEC7A ALLC
22 amyotrophic lateral sclerosis 3 9.7 CLEC7A ALLC
23 cryptococcosis 9.7 CLEC7A ALLC
24 opportunistic mycosis 9.6 CLEC7A ALLC
25 amyotrophic lateral sclerosis 1 8.9 MT-CO1 LGALS3 CLEC7A ALLC

Graphical network of the top 20 diseases related to Neonatal Candidiasis:



Diseases related to Neonatal Candidiasis

Symptoms & Phenotypes for Neonatal Candidiasis

Drugs & Therapeutics for Neonatal Candidiasis

Drugs for Neonatal Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2, Phase 3 86386-73-4 3365
2
Micafungin Approved, Investigational Phase 3 235114-32-6 3081921 477468
3
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
4
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
5
deoxycholic acid Approved Phase 3 83-44-3 222528
6 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
7 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
8 Hormone Antagonists Phase 2, Phase 3
9 Steroid Synthesis Inhibitors Phase 2, Phase 3
10 Cytochrome P-450 CYP2C9 Inhibitors Phase 2, Phase 3
11 Hormones Phase 2, Phase 3
12 Anti-Bacterial Agents Phase 3
13 Gastrointestinal Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Antiparasitic Agents Phase 3
16 Antiprotozoal Agents Phase 3
17 Cholagogues and Choleretics Phase 3
18 Antifungal Agents Phase 3
19 Amphotericin B, deoxycholate drug combination Phase 3
20 Liposomal amphotericin B Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fluconazole Versus Micafungin in Neonates With Suspected or Culture-proven Candidiasis: a Randomized Pharmacokinetic and Safety Study (TINN Project - Treat Infections iN Neonates) Unknown status NCT02145832 Phase 2, Phase 3 Fluconazole;Micafungin
2 A Phase 3, Randomized, Double-Blind, Multi-Center Study to Compare the Efficacy and Safety of Micafungin Versus Amphotericin B Deoxycholate for the Treatment of Neonatal Candidiasis Terminated NCT00815516 Phase 3 micafungin;amphotericin B deoxycholate

Search NIH Clinical Center for Neonatal Candidiasis

Genetic Tests for Neonatal Candidiasis

Anatomical Context for Neonatal Candidiasis

MalaCards organs/tissues related to Neonatal Candidiasis:

40
Colon, Skin, Liver, Neutrophil, Eye

Publications for Neonatal Candidiasis

Articles related to Neonatal Candidiasis:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Vaginal yeast colonisation: From a potential harmless condition to clinical implications and management approaches-A literature review. 61
31038771 2019
2
Maternal pregnancy-induced hypertension increases the subsequent risk of neonatal candidiasis: A nationwide population-based cohort study. 61
30910150 2019
3
Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. 61
29369937 2018
4
Spectrum of candidal species isolated from neonates admitted in an Intensive Care Unit of teaching hospital of Kashmir, North India. 61
30078958 2018
5
Exposure-Response Analysis of Micafungin in Neonatal Candidiasis: Pooled Analysis of Two Clinical Trials. 61
29762386 2018
6
Comprehensive drug utilization review in neonates: liposomal amphotericin B. 61
29365355 2018
7
Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome. 61
28077516 2017
8
Common Skin Conditions in Children: Neonatal Skin Lesions. 61
28196316 2017
9
Candida parapsilosis Secreted Lipase as an Important Virulence Factor. 61
27526931 2017
10
Fatal Neonatal Peritoneal Candidiasis Mimicking Mucormycosis-A Case Report and Review of Literature. 61
27185733 2016
11
Neonatal Candidiasis: New Insights into an Old Problem at a Unique Host-Pathogen Interface. 61
26779297 2015
12
Clinical spectrum, management and outcome of neonatal candidiasis. 61
26564294 2015
13
Advances in the treatment of invasive neonatal candidiasis. 61
25842986 2015
14
Neonatal candidiasis: diagnosis, prevention, and treatment. 61
25129318 2014
15
Phenotypic consequences of LYS4 gene disruption in Candida albicans. 61
24898203 2014
16
The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils. 61
23279221 2013
17
Time to initiation of antifungal therapy for neonatal candidiasis. 61
23507285 2013
18
Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. 61
22982980 2012
19
Candida virulence properties and adverse clinical outcomes in neonatal candidiasis. 61
22504098 2012
20
Congenital cutaneous candidiasis in two full-term infants. 61
21906141 2012
21
Neonatal candidiasis: results of an 8 year study. 61
22320707 2012
22
Strategies for the prevention of neonatal candidiasis. 61
22503254 2012
23
The use of antifungal therapy in neonatal intensive care. 61
22341539 2012
24
Disseminated candidemia refractory to caspofungin therapy in an infant with extremely low birth weight. 61
22333013 2012
25
Incidence of vesicobullous and erosive disorders of neonates. 61
22408704 2011
26
Incidence of Vesicobullous and Erosive Disorders of Neonates: Where and How Much to Worry? 61
22037857 2011
27
A rat model of neonatal candidiasis demonstrates the importance of lipases as virulence factors for Candida albicans and Candida parapsilosis. 61
21667319 2011
28
Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. 61
21518846 2011
29
Clinical spectrum and outcomes of neonatal candidiasis in a tertiary care hospital in Karachi, Pakistan. 61
21444991 2011
30
Outcomes of neonatal candidiasis: the impact of delayed initiation of antifungal therapy. 61
22121380 2011
31
Congenital cutaneous candidiasis: a rare and unpredictable disease. 61
21572803 2011
32
Clinical microbiology of neonatal candidiasis in Hungary. 61
21183426 2010
33
Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. 61
20876174 2010
34
Challenging issues in neonatal candidiasis. 61
20513206 2010
35
Outbreak of Candida parapsilosis in a neonatal intensive care unit: a health care workers source. 61
19957192 2010
36
Recent Advances in the Detection of Neonatal Candidiasis. 61
20454602 2010
37
Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? 61
20204759 2010
38
A clinical review of echinocandins in pediatric patients. 61
20009006 2010
39
Neonatal candidaemia in Kuwait: a 12-year study of risk factors, species spectrum and antifungal susceptibility. 61
18983425 2009
40
Neonatal liver abscesses due to Candida infection effectively treated with caspofungin. 61
19187395 2009
41
[Neonatal candidiasis: therapeutic options]. 61
19536371 2008
42
Antifungal prophylaxis for the prevention of neonatal candidiasis? 61
18363952 2008
43
Antifungal therapy for neonatal candidiasis. 61
17975409 2007
44
Candida isolated from vaginal mucosa of mothers and oral mucosa of neonates: occurrence and biotypes concordance. 61
17596793 2007
45
Outcomes attributable to neonatal candidiasis. 61
17407037 2007
46
Neonatal invasive candidiasis. 61
17093376 2006
47
Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. 61
16982807 2006
48
Fluconazole for the management of invasive candidiasis: where do we stand after 15 years? 61
16449304 2006
49
Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. 61
16396864 2006
50
Survey of neonatal candidiasis in Greece. 61
16283219 2005

Variations for Neonatal Candidiasis

Expression for Neonatal Candidiasis

Search GEO for disease gene expression data for Neonatal Candidiasis.

Pathways for Neonatal Candidiasis

GO Terms for Neonatal Candidiasis

Biological processes related to Neonatal Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.62 LCE4A C1orf68

Sources for Neonatal Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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