MCID: NNT038
MIFTS: 18

Neonatal Glycine Encephalopathy

Categories: Neuronal diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Neonatal Glycine Encephalopathy

MalaCards integrated aliases for Neonatal Glycine Encephalopathy:

Name: Neonatal Glycine Encephalopathy 59
Neonatal Non-Ketotic Hyperglycinemia 59
Classic Glycine Encephalopathy 59
Neonatal Nkh 59

Characteristics:

Orphanet epidemiological data:

59
neonatal glycine encephalopathy
Inheritance: Autosomal recessive; Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 59 ORPHA289857
UMLS via Orphanet 74 C0751748
ICD10 via Orphanet 34 E72.5

Summaries for Neonatal Glycine Encephalopathy

MalaCards based summary : Neonatal Glycine Encephalopathy, also known as neonatal non-ketotic hyperglycinemia, is related to glycine encephalopathy and encephalopathy. An important gene associated with Neonatal Glycine Encephalopathy is GLDC (Glycine Decarboxylase), and among its related pathways/superpathways are Viral mRNA Translation and Carbon metabolism.

Related Diseases for Neonatal Glycine Encephalopathy

Diseases related to Neonatal Glycine Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 glycine encephalopathy 27.5 AMT GCSH GLDC
2 encephalopathy 9.8
3 autosomal recessive disease 9.2 AMT GLDC
4 infantile glycine encephalopathy 8.7 AMT GCSH GLDC
5 glycine encephalopathy with normal serum glycine 8.6 AMT GCSH GLDC

Graphical network of the top 20 diseases related to Neonatal Glycine Encephalopathy:



Diseases related to Neonatal Glycine Encephalopathy

Symptoms & Phenotypes for Neonatal Glycine Encephalopathy

Drugs & Therapeutics for Neonatal Glycine Encephalopathy

Search Clinical Trials , NIH Clinical Center for Neonatal Glycine Encephalopathy

Genetic Tests for Neonatal Glycine Encephalopathy

Anatomical Context for Neonatal Glycine Encephalopathy

Publications for Neonatal Glycine Encephalopathy

Articles related to Neonatal Glycine Encephalopathy:

# Title Authors Year
1
Neonatal glycine encephalopathy: biochemical and neuropathologic findings. ( 8499044 )
1993

Variations for Neonatal Glycine Encephalopathy

Expression for Neonatal Glycine Encephalopathy

Search GEO for disease gene expression data for Neonatal Glycine Encephalopathy.

Pathways for Neonatal Glycine Encephalopathy

Pathways related to Neonatal Glycine Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 AMT GCSH GLDC
2
Show member pathways
11.76 AMT GCSH GLDC
3
Show member pathways
11.05 AMT GCSH GLDC
4
Show member pathways
10.74 AMT GCSH GLDC
5 10.25 AMT GCSH GLDC

GO Terms for Neonatal Glycine Encephalopathy

Cellular components related to Neonatal Glycine Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.33 AMT GCSH GLDC
2 mitochondrial matrix GO:0005759 9.13 AMT GCSH GLDC
3 glycine cleavage complex GO:0005960 8.62 GCSH GLDC

Biological processes related to Neonatal Glycine Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 methylation GO:0032259 9.16 AMT GCSH
2 glycine decarboxylation via glycine cleavage system GO:0019464 9.13 AMT GCSH GLDC
3 glycine catabolic process GO:0006546 8.8 AMT GCSH GLDC

Molecular functions related to Neonatal Glycine Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aminomethyltransferase activity GO:0004047 8.62 AMT GCSH

Sources for Neonatal Glycine Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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