MCID: NNT018
MIFTS: 27

Neonatal Herpes

Categories: Rare diseases

Aliases & Classifications for Neonatal Herpes

MalaCards integrated aliases for Neonatal Herpes:

Name: Neonatal Herpes 53 73
Neonatal Herpes Simplex Virus Infection 53
Congenital Herpes Simplex 73
Neonatal Hsv Infection 53

Classifications:



External Ids:

Summaries for Neonatal Herpes

MalaCards based summary : Neonatal Herpes, also known as neonatal herpes simplex virus infection, is related to congenital herpes simplex virus infection and herpes simplex. An important gene associated with Neonatal Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)). The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Related Diseases for Neonatal Herpes

Diseases related to Neonatal Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 congenital herpes simplex virus infection 11.0
2 herpes simplex 10.7
3 encephalitis 10.3
4 herpes simplex encephalitis 10.1
5 pneumonia 10.0
6 retinitis 9.9
7 meningoencephalitis 9.9
8 hepatitis 9.9
9 genital herpes 9.8
10 cerebritis 9.8
11 cytomegalovirus infection 9.8
12 infantile liver failure syndrome 1 9.8
13 acute liver failure 9.8
14 meningitis 9.7
15 congenital cytomegalovirus 9.7
16 central nervous system disease 9.7
17 malakoplakia 9.7
18 incontinentia pigmenti 9.7
19 aging 9.7
20 stromal keratitis 9.7
21 hemophagocytic lymphohistiocytosis 9.7
22 nervous system disease 9.7
23 uveitis 9.5
24 eczema herpeticum 9.5
25 cerebral degeneration 9.5
26 herpes gestationis 9.5
27 blepharoconjunctivitis 9.5
28 type i 9.5
29 cervicitis 9.5
30 conjunctivitis 9.5
31 impetigo 9.5
32 bullous impetigo 9.5
33 herpes zoster 9.5
34 hepatitis b 9.5
35 erythema multiforme 9.5
36 vasculitis 9.5

Graphical network of the top 20 diseases related to Neonatal Herpes:



Diseases related to Neonatal Herpes

Symptoms & Phenotypes for Neonatal Herpes

Drugs & Therapeutics for Neonatal Herpes

Drugs for Neonatal Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3,Phase 1,Phase 2 59277-89-3 2022
2 Anti-Infective Agents Phase 3,Phase 1,Phase 2
3 Antiviral Agents Phase 3,Phase 1,Phase 2
4 Antibodies Not Applicable
5 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
2 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
3 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo
6 HSV Seroprevalence and Diagnosis of Genital Herpes in Pregnant Women Completed NCT00291044
7 A Study of HSV Testing Among Pregnant Women Terminated NCT00194415 Not Applicable

Search NIH Clinical Center for Neonatal Herpes

Genetic Tests for Neonatal Herpes

Anatomical Context for Neonatal Herpes

MalaCards organs/tissues related to Neonatal Herpes:

41
Skin, Eye, Testes, Liver, Brain, Lung

Publications for Neonatal Herpes

Articles related to Neonatal Herpes:

(show top 50) (show all 336)
# Title Authors Year
1
Neonatal herpes simplex virus infections. ( 29544668 )
2018
2
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )
2018
3
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. ( 29174006 )
2018
4
Neonatal Herpes Simplex Viral Infections and Acyclovir: An Update. ( 28469532 )
2017
5
Disseminated Neonatal Herpes Simplex Virus Infection with Escherichia Coli Coinfection. ( 28678413 )
2017
6
Why neonatal herpes matters. ( 28153515 )
2017
7
Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure. ( 28392553 )
2017
8
Disseminated Neonatal Herpes Simplex Virus Type 1 After a Water Birth. ( 28510692 )
2017
9
Preventing neonatal herpes infections through maternal immunization. ( 29339967 )
2017
10
First estimates of the global and regional incidence of neonatal herpes infection. ( 28153513 )
2017
11
Fatal disseminated neonatal herpes simplex virus type 1 infection in neonates in a forensic setting. ( 28101751 )
2017
12
Diagnostic Pitfalls of Neonatal Herpes Infection. ( 26955143 )
2016
13
Stromal keratitis in a neonate: Herpes virus a diagnosis to consider. ( 26710660 )
2016
14
Testing and Empiric Treatment for Neonatal Herpes Simplex Virus: Challenges and Opportunities for Improving the Value of Care. ( 26740558 )
2016
15
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
16
Biting Cousins-Disseminated Neonatal Herpes Simplex Virus Infection from a Human Bite. ( 26581494 )
2016
17
Safety of High-Dose Acyclovir in Infants with Suspected and Confirmed Neonatal Herpes Simplex Virus Infections. ( 27977557 )
2016
18
Initial Presentation of Neonatal Herpes Simplex Virus Infection. ( 26960921 )
2016
19
Cutaneous neonatal herpes simplex virus infection type 2: a case report. ( 27192523 )
2016
20
Neonatal Herpes Simplex Virus Infection. ( 26154662 )
2015
21
Massive Ferritin Elevation in Neonatal Herpes Simplex Virus Infection: Hemophagocytic Lymphohistiocytosis or Herpes Simplex Virus Alone? ( 26407444 )
2015
22
Neonatal herpes simplex virus infection: epidemiology and treatment. ( 25677996 )
2015
23
Fatal Neonatal Herpes Simplex Infection Likely from Unrecognized Breast Lesions. ( 26185119 )
2015
24
Neonatal Herpes Simplex Virus Type 1 Infection and Jewish Ritual Circumcision With Oral Suction: A Systematic Review. ( 26407411 )
2015
25
Recontact and Recruitment of Young Adults Previously Enrolled in Neonatal Herpes Simplex Virus Research. ( 26479108 )
2015
26
Neonatal Herpes Infection Associated With Direct Orogenital Suction During Ritual Jewish Circumcision. ( 26407435 )
2015
27
Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. ( 26390826 )
2015
28
Challenges in the care of young infants with suspected neonatal herpes simplex virus. ( 25646205 )
2015
29
Response to Recent Review of Literature on Transmission of Neonatal Herpes Through Ritual Circumcision With Oral Suction. ( 26407436 )
2015
30
The Mortality of Neonatal Herpes Simplex Virus Infection. ( 25868428 )
2015
31
Editorial Comment: Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611873 )
2014
32
Population-based surveillance of neonatal herpes simplex virus infection in Australia, 1997-2011. ( 24846638 )
2014
33
Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. ( 25149136 )
2014
34
Prolonged maternal postpartum fever and neonatal herpes infection. ( 25179382 )
2014
35
Prevention and management of neonatal herpes simplex virus infections. ( 24855418 )
2014
36
Safety of alternative antiviral agents for neonatal herpes simplex virus encephalitis and disseminated infection. ( 25024666 )
2014
37
Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease with Acute Retinal Necrosis. ( 24378951 )
2014
38
Clinical and neuroimaging findings in neonatal herpes simplex virusA infection. ( 24929330 )
2014
39
Neonatal herpes infections in The Netherlands in the period 2006-2011. ( 25014318 )
2014
40
Hospitalization Cost per Case of Neonatal Herpes Simplex Virus Infection From Claims Data. ( 25193688 )
2014
41
The incidence and presentation of neonatal herpes in a single UK tertiary centre, 2006-2013. ( 24919712 )
2014
42
Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611872 )
2014
43
Management of neonatal herpes simplex virus infection and exposure. ( 24589428 )
2014
44
Neonatal herpes simplex 2 infection presenting with supraglottitis. ( 23709315 )
2013
45
The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention. ( 23606868 )
2013
46
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. ( 23111154 )
2013
47
Maternal and neonatal herpes simplex virus infections. ( 23303485 )
2013
48
Pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation. ( 23097453 )
2013
49
Mammary herpes: a little known mode of neonatal herpes contamination. ( 23986091 )
2013
50
Neonatal herpes encephalitis caused by a virologically confirmed acyclovir-resistant herpes simplex virus 1 strain. ( 23100343 )
2013

Variations for Neonatal Herpes

Expression for Neonatal Herpes

Search GEO for disease gene expression data for Neonatal Herpes.

Pathways for Neonatal Herpes

GO Terms for Neonatal Herpes

Sources for Neonatal Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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