MCID: NNT018
MIFTS: 25

Neonatal Herpes

Categories: Rare diseases

Aliases & Classifications for Neonatal Herpes

MalaCards integrated aliases for Neonatal Herpes:

Name: Neonatal Herpes 54 74
Neonatal Herpes Simplex Virus Infection 54
Congenital Herpes Simplex 74
Neonatal Hsv Infection 54

Classifications:



External Ids:

Summaries for Neonatal Herpes

MalaCards based summary : Neonatal Herpes, also known as neonatal herpes simplex virus infection, is related to congenital herpes simplex virus infection and herpes simplex. An important gene associated with Neonatal Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)). The drugs Acyclovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Related Diseases for Neonatal Herpes

Diseases related to Neonatal Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 congenital herpes simplex virus infection 11.2
2 herpes simplex 10.9
3 encephalitis 10.5
4 herpes simplex encephalitis 10.2
5 pneumonia 10.1
6 meningoencephalitis 10.0
7 genital herpes 10.0
8 infantile liver failure syndrome 1 10.0
9 incontinentia pigmenti 9.9
10 acute liver failure 9.9
11 hepatitis 9.9
12 retinitis 9.9
13 cytomegalovirus infection 9.9
14 keratitis, hereditary 9.8
15 hemophagocytic lymphohistiocytosis 9.8
16 central nervous system disease 9.8
17 nervous system disease 9.8
18 meningitis 9.8
19 congenital cytomegalovirus 9.8
20 malakoplakia 9.8
21 stromal keratitis 9.8
22 hepatitis b 9.7
23 erythema multiforme 9.7
24 uveitis 9.7
25 cerebral degeneration 9.7
26 pemphigoid gestationis 9.7
27 blepharoconjunctivitis 9.7
28 cervicitis 9.7
29 dermatitis 9.7
30 conjunctivitis 9.7
31 impetigo 9.7
32 herpes zoster 9.7
33 vasculitis 9.7
34 chorioretinitis 9.7
35 eczema herpeticum 9.7
36 bullous impetigo 9.7

Graphical network of the top 20 diseases related to Neonatal Herpes:



Diseases related to Neonatal Herpes

Symptoms & Phenotypes for Neonatal Herpes

Drugs & Therapeutics for Neonatal Herpes

Drugs for Neonatal Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3,Phase 1,Phase 2 59277-89-3 2022
2 Anti-Infective Agents Phase 3,Phase 1,Phase 2
3 Antiviral Agents Phase 3,Phase 1,Phase 2
4 Antibodies Not Applicable
5 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
2 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
3 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo
6 HSV Seroprevalence and Diagnosis of Genital Herpes in Pregnant Women Completed NCT00291044
7 A Study of HSV Testing Among Pregnant Women Terminated NCT00194415 Not Applicable

Search NIH Clinical Center for Neonatal Herpes

Genetic Tests for Neonatal Herpes

Anatomical Context for Neonatal Herpes

MalaCards organs/tissues related to Neonatal Herpes:

42
Skin, Eye, Testes, Brain

Publications for Neonatal Herpes

Articles related to Neonatal Herpes:

(show top 50) (show all 353)
# Title Authors Year
1
Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. ( 30911082 )
2019
2
Neonatal Herpes Simplex Virus Infections: New Data, Old Conundrum. ( 30923057 )
2019
3
Neonatal Herpes Simplex Virus Infection Among Medicaid-Enrolled Children: 2009-2015. ( 30923058 )
2019
4
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. ( 30971454 )
2019
5
Congenital neonatal herpes simplex retinitis. ( 31109490 )
2019
6
Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections. ( 30602444 )
2019
7
Disseminated neonatal herpes simplex virus infection: Postnatal acquisition and familial spread during migration to Germany. ( 30639782 )
2019
8
Incidence and Characteristics of Neonatal Herpes: Comparison of Two Population-Based Data Sources, New York City, 2006-2015. ( 30640862 )
2019
9
Critically Severe Case of Neonatal Herpes with High Viral Load and Hemophagocytic Syndrome. ( 30828029 )
2019
10
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2018
11
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. ( 29174006 )
2018
12
Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection. ( 30009071 )
2018
13
Neonatal herpes simplex virus infections. ( 29544668 )
2018
14
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )
2018
15
Disseminated Neonatal Herpes Simplex Virus Infection with Escherichia Coli Coinfection. ( 28678413 )
2018
16
Sixty seconds on . . . neonatal herpes. ( 30209054 )
2018
17
Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure. ( 28392553 )
2017
18
Neonatal Herpes Simplex Viral Infections and Acyclovir: An Update. ( 28469532 )
2017
19
Disseminated Neonatal Herpes Simplex Virus Type 1 After a Water Birth. ( 28510692 )
2017
20
Safety of High-dose Acyclovir in Infants With Suspected and Confirmed Neonatal Herpes Simplex Virus Infections. ( 27977557 )
2017
21
Fatal disseminated neonatal herpes simplex virus type 1 infection in neonates in a forensic setting. ( 28101751 )
2017
22
First estimates of the global and regional incidence of neonatal herpes infection. ( 28153513 )
2017
23
Why neonatal herpes matters. ( 28153515 )
2017
24
Preventing neonatal herpes infections through maternal immunization. ( 29339967 )
2017
25
Initial Presentation of Neonatal Herpes Simplex Virus Infection. ( 26960921 )
2016
26
Cutaneous neonatal herpes simplex virus infection type 2: a case report. ( 27192523 )
2016
27
Biting Cousins-Disseminated Neonatal Herpes Simplex Virus Infection from a Human Bite. ( 26581494 )
2016
28
Testing and Empiric Treatment for Neonatal Herpes Simplex Virus: Challenges and Opportunities for Improving the Value of Care. ( 26740558 )
2016
29
Fatal Neonatal Herpes Simplex Infection Likely from Unrecognized Breast Lesions. ( 26185119 )
2016
30
Diagnostic Pitfalls of Neonatal Herpes Infection. ( 26955143 )
2016
31
Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. ( 26390826 )
2015
32
Massive Ferritin Elevation in Neonatal Herpes Simplex Virus Infection: Hemophagocytic Lymphohistiocytosis or Herpes Simplex Virus Alone? ( 26407444 )
2015
33
Recontact and Recruitment of Young Adults Previously Enrolled in Neonatal Herpes Simplex Virus Research. ( 26479108 )
2015
34
Neonatal Herpes Simplex Virus Infection. ( 26154662 )
2015
35
Neonatal Herpes Simplex Virus Type 1 Infection and Jewish Ritual Circumcision With Oral Suction: A Systematic Review. ( 26407411 )
2015
36
The mortality of neonatal herpes simplex virus infection. ( 25868428 )
2015
37
Challenges in the care of young infants with suspected neonatal herpes simplex virus. ( 25646205 )
2015
38
Neonatal herpes simplex virus infection: epidemiology and treatment. ( 25677996 )
2015
39
Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. ( 25149136 )
2015
40
Hospitalization cost per case of neonatal herpes simplex virus infection from claims data. ( 25193688 )
2015
41
Neonatal herpes infections in The Netherlands in the period 2006-2011. ( 25014318 )
2015
42
Neonatal Herpes Infection Associated With Direct Orogenital Suction During Ritual Jewish Circumcision. ( 26407435 )
2015
43
Response to Recent Review of Literature on Transmission of Neonatal Herpes Through Ritual Circumcision With Oral Suction. ( 26407436 )
2015
44
Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis. ( 24378951 )
2014
45
Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611872 )
2014
46
Editorial Comment: Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611873 )
2014
47
Clinical and neuroimaging findings in neonatal herpes simplex virus infection. ( 24929330 )
2014
48
Safety of alternative antiviral agents for neonatal herpes simplex virus encephalitis and disseminated infection. ( 25024666 )
2014
49
Management of neonatal herpes simplex virus infection and exposure. ( 24589428 )
2014
50
Population-based surveillance of neonatal herpes simplex virus infection in Australia, 1997-2011. ( 24846638 )
2014

Variations for Neonatal Herpes

Expression for Neonatal Herpes

Search GEO for disease gene expression data for Neonatal Herpes.

Pathways for Neonatal Herpes

GO Terms for Neonatal Herpes

Sources for Neonatal Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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