MCID: NNT018
MIFTS: 23

Neonatal Herpes

Categories: Rare diseases

Aliases & Classifications for Neonatal Herpes

MalaCards integrated aliases for Neonatal Herpes:

Name: Neonatal Herpes 20 70
Neonatal Herpes Simplex Virus Infection 20
Congenital Herpes Simplex 70
Neonatal Hsv Infection 20

Classifications:



External Ids:

UMLS 70 C0276225 C2931185

Summaries for Neonatal Herpes

MalaCards based summary : Neonatal Herpes, also known as neonatal herpes simplex virus infection, is related to congenital herpes simplex and herpes simplex. An important gene associated with Neonatal Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)). The drug valacyclovir has been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver.

Related Diseases for Neonatal Herpes

Diseases related to Neonatal Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 congenital herpes simplex 11.1
2 herpes simplex 11.0
3 encephalitis 10.7
4 genital herpes 10.6
5 herpes simplex encephalitis 10.5
6 nervous system disease 10.4
7 central nervous system disease 10.4
8 meningoencephalitis 10.2
9 mouth disease 10.2
10 exanthem 10.1
11 neuroretinitis 10.1
12 disseminated intravascular coagulation 10.1
13 retinitis 10.1
14 congenital cytomegalovirus 10.1
15 thrombocytopenia 10.1
16 acute liver failure 10.1
17 incontinentia pigmenti 10.0
18 hemophagocytic lymphohistiocytosis 10.0
19 human cytomegalovirus infection 10.0
20 encephalomalacia 10.0
21 conjunctivitis 10.0
22 meningitis 10.0
23 keratitis, hereditary 9.9
24 sensorineural hearing loss 9.9
25 microcephaly 9.9
26 neutropenia 9.9
27 pneumonia 9.9
28 herpes zoster 9.9
29 chickenpox 9.9
30 chorioretinitis 9.9
31 bacterial meningitis 9.9
32 malakoplakia 9.9
33 dowling-degos disease 1 9.8
34 thrombocytopenia 2 9.8
35 3-methylglutaconic aciduria, type iii 9.8
36 yemenite deaf-blind hypopigmentation syndrome 9.8
37 dermatitis, atopic 9.8
38 cyanosis, transient neonatal 9.8
39 carbonic anhydrase va deficiency, hyperammonemia due to 9.8
40 bacterial sepsis 9.8
41 disease by infectious agent 9.8
42 erythema multiforme 9.8
43 endometritis 9.8
44 bacterial infectious disease 9.8
45 mastitis 9.8
46 hydrocephalus 9.8
47 hemiplegia 9.8
48 chlamydia 9.8
49 retinal vasculitis 9.8
50 cortical blindness 9.8

Graphical network of the top 20 diseases related to Neonatal Herpes:



Diseases related to Neonatal Herpes

Symptoms & Phenotypes for Neonatal Herpes

Drugs & Therapeutics for Neonatal Herpes

Drugs for Neonatal Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 valacyclovir Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
2 A Placebo-Controlled Phase III Evaluation of Suppressive Therapy With Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Limited to the Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
3 A Placebo-Controlled Phase III Evaluation of Suppressive Therapy With Oral Acyclovir Suspension Following Neonatal Herpes Simplex Virus Infections Involving the Central Nervous System Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo
6 Evaluation of the Pharmacokinetics and Pharmacodynamics of Valacyclovir in Neonates With Neonatal Herpes Simplex Virus Disease Who Have Completed Standard of Care Treatment With Acyclovir Not yet recruiting NCT04448392 Phase 1 Valacyclovir

Search NIH Clinical Center for Neonatal Herpes

Genetic Tests for Neonatal Herpes

Anatomical Context for Neonatal Herpes

MalaCards organs/tissues related to Neonatal Herpes:

40
Skin, Eye, Liver, Bone Marrow, Placenta, Cervix, Thalamus

Publications for Neonatal Herpes

Articles related to Neonatal Herpes:

(show top 50) (show all 718)
# Title Authors PMID Year
1
Lifetime Medical Costs of Genital Herpes in the United States: Estimates From Insurance Claims. 61
33492102 2021
2
Prolonged fever and hyperferritinaemia: a puzzling diagnosis of neonatal herpes simplex virus infection during COVID-19 pandemic. 61
33692072 2021
3
Precision in Cardiovascular Care Using Targeted Neonatal Echocardiography in Lethal Neonatal Disseminated Herpes Infection: A Case Series. 61
33470772 2021
4
Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections. 61
33386334 2021
5
Herpes Simplex Virus Serotyping in Pregnant Women With a History of Genital Herpes and an Outbreak in the Third Trimester of Pregnancy: A Cost-Effectiveness Analysis. 61
33278294 2021
6
Protection against herpes simplex virus type 2 infection in a neonatal murine model using a trivalent nucleoside-modified mRNA in lipid nanoparticle vaccine. 61
33041105 2020
7
Bilateral acute retinal necrosis with encephalitis in a premature infant. 61
33153297 2020
8
Herpes simplex virus type 1 infection leads to neurodevelopmental disorder-associated neuropathological changes. 61
33091073 2020
9
Neonatal herpes simplex infection acquired from herpes mastitis: An unusual mode of transmission. 61
32769305 2020
10
Feasibility of Continuous Infusions of Acyclovir. 61
32796409 2020
11
Australian Paediatric Surveillance Unit (APSU) Annual Surveillance Report 2019. 61
32829700 2020
12
Postnatal Exposure to Herpes Simplex Virus: To Treat or Not to Treat? 61
32773663 2020
13
Vaccines against Genital Herpes: Where Are We? 61
32727077 2020
14
Vaccines to prevent genital herpes. 61
32272093 2020
15
Estimating neonatal herpes simplex virus incidence and mortality using capture-recapture, Florida. 61
32507882 2020
16
Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report. 61
31887772 2020
17
Trivalent Glycoprotein Subunit Vaccine Prevents Neonatal Herpes Simplex Virus Mortality and Morbidity. 61
32188735 2020
18
Diagnosis and Management of Neonatal Herpes Simplex Infection in the Emergency Department. 61
32265379 2020
19
Acute Kidney Injury During Treatment with Intravenous Acyclovir for Suspected or Confirmed Neonatal Herpes Simplex Virus Infection. 61
32037154 2020
20
Prevention and treatment of neonatal herpes simplex virus infection. 61
32044154 2020
21
Neonatal Herpes Simplex Virus: The Long Road to Improved Outcomes. 61
32317339 2020
22
Herpes Simplex Infection During Pregnancy, Results of a Tertiary Referral Center in Turkey. 61
30831604 2020
23
Murine Model of Maternal Immunization Demonstrates Protective Role for Antibodies That Mediate Antibody-Dependent Cellular Cytotoxicity in Protecting Neonates From Herpes Simplex Virus Type 1 and Type 2. 61
31599942 2020
24
Genital zoster in near term pregnancy: Case report and need of management guidelines. 61
31852623 2020
25
[Genital herpes simplex virus infection in pregnancy]. 61
32052736 2020
26
Diagnosis of Neonatal Herpes Simplex Infection from the Placenta. 61
33520322 2020
27
Herpes in the Heart: A Case of Widely Disseminated Intrauterine Herpes Simplex Virus Infection Involving Neonatal Myocardium in a 23-Week Gestationally Aged Neonate. 61
32908733 2020
28
Evaluation of suspected neonatal herpes simplex virus infection in preterm versus term newborns in the neonatal intensive care unit. 61
32083595 2020
29
Mortality from neonatal herpes simplex viremia causing severe hepatitis. 61
31347030 2019
30
Viral genetic diversity and its potential contributions to the development and progression of neonatal herpes simplex virus (HSV) disease. 61
32944492 2019
31
Biologic interactions between HSV-2 and HIV-1 and possible implications for HSV vaccine development. 61
28958807 2019
32
Utility of Surface and Blood Polymerase Chain Reaction Assays in Identifying Infants With Neonatal Herpes Simplex Virus Infection. 61
31626049 2019
33
Maintaining Breastfeeding During Severe Infant and Maternal HSV-1 Infection: A Case Report. 61
30840531 2019
34
Meeting report: Initial World Health Organization consultation on herpes simplex virus (HSV) vaccine preferred product characteristics, March 2017. 61
29224963 2019
35
Inconsistent Management of Neonatal Herpes Simplex Virus Infections. 61
31570510 2019
36
New dl5-29-Attenuated Replication-Deficient HSV Vaccine Provides a Ray of Hope for the Prevention of Neonatal HSV Infection. 61
31478773 2019
37
Using Quality Improvement to Implement a Standardized Approach to Neonatal Herpes Simplex Virus. 61
31345997 2019
38
Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants ≤60 Days of Age Undergoing Evaluation for Meningitis. 61
31112493 2019
39
Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat? 61
31205247 2019
40
Congenital neonatal herpes simplex retinitis. 61
31109490 2019
41
Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018. 61
31124465 2019
42
Trends in the incidence, mortality, and cost of neonatal herpes simplex virus hospitalizations in the United States from 2003 to 2014. 61
30911082 2019
43
Laboratory Diagnosis of Neonatal Herpes Simplex Virus Infections. 61
30602444 2019
44
Disseminated neonatal herpes simplex virus infection: Postnatal acquisition and familial spread during migration to Germany. 61
30639782 2019
45
Neonatal Herpes Simplex Virus Infections: New Data, Old Conundrum. 61
30923057 2019
46
Neonatal Herpes Simplex Virus Infection Among Medicaid-Enrolled Children: 2009-2015. 61
30923058 2019
47
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. 61
30971454 2019
48
[6-month-old female with increasing hyperpigmentation following suspected neonatal HSV infection : Preparation for the specialist examination: part 30]. 61
30976862 2019
49
Critically Severe Case of Neonatal Herpes with High Viral Load and Hemophagocytic Syndrome. 61
30828029 2019
50
Incidence and Characteristics of Neonatal Herpes: Comparison of Two Population-Based Data Sources, New York City, 2006-2015. 61
30640862 2019

Variations for Neonatal Herpes

Expression for Neonatal Herpes

Search GEO for disease gene expression data for Neonatal Herpes.

Pathways for Neonatal Herpes

GO Terms for Neonatal Herpes

Sources for Neonatal Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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