MCID: NNT018
MIFTS: 26

Neonatal Herpes

Categories: Rare diseases

Aliases & Classifications for Neonatal Herpes

MalaCards integrated aliases for Neonatal Herpes:

Name: Neonatal Herpes 53 73
Neonatal Herpes Simplex Virus Infection 53
Congenital Herpes Simplex 73
Neonatal Hsv Infection 53

Classifications:



External Ids:

Summaries for Neonatal Herpes

MalaCards based summary : Neonatal Herpes, also known as neonatal herpes simplex virus infection, is related to congenital herpes simplex virus infection and herpes simplex. An important gene associated with Neonatal Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)). The drugs Acyclovir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver.

Related Diseases for Neonatal Herpes

Diseases related to Neonatal Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 congenital herpes simplex virus infection 11.2
2 herpes simplex 10.8
3 viral infectious disease 10.6
4 encephalitis 10.5
5 herpes simplex encephalitis 10.2
6 pneumonia 10.1
7 meningoencephalitis 10.0
8 infantile liver failure syndrome 1 9.9
9 genital herpes 9.9
10 incontinentia pigmenti 9.9
11 acute liver failure 9.9
12 hepatitis 9.9
13 cytomegalovirus infection 9.9
14 hemophagocytic lymphohistiocytosis 9.8
15 central nervous system disease 9.8
16 retinitis 9.8
17 nervous system disease 9.8
18 meningitis 9.8
19 congenital cytomegalovirus 9.8
20 malakoplakia 9.8
21 stromal keratitis 9.8
22 hepatitis b 9.6
23 erythema multiforme 9.6
24 uveitis 9.6
25 cerebral degeneration 9.6
26 herpes gestationis 9.6
27 blepharoconjunctivitis 9.6
28 cervicitis 9.6
29 conjunctivitis 9.6
30 impetigo 9.6
31 herpes zoster 9.6
32 vasculitis 9.6
33 eczema herpeticum 9.6
34 bullous impetigo 9.6

Graphical network of the top 20 diseases related to Neonatal Herpes:



Diseases related to Neonatal Herpes

Symptoms & Phenotypes for Neonatal Herpes

Drugs & Therapeutics for Neonatal Herpes

Drugs for Neonatal Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 3,Phase 1,Phase 2 59277-89-3 2022
2 Antiviral Agents Phase 3,Phase 1,Phase 2
3 Anti-Infective Agents Phase 3,Phase 1,Phase 2
4 Immunoglobulins Not Applicable
5 Antibodies Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Placebo-Controlled Study of Acyclovir Oral Suspension for Neonatal Herpes Simplex Virus Infection Limited to the Skin, Eyes, and Mouth Completed NCT00004757 Phase 3 acyclovir
2 Acyclovir Herpes Simplex Virus (HSV) Skin, Eye, and Mouth Completed NCT00031447 Phase 3 Acyclovir;Placebo
3 Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates Completed NCT00031460 Phase 3 Acyclovir;Placebo
4 Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection Completed NCT00004644 Phase 1, Phase 2 acyclovir
5 A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease) Withdrawn NCT01610765 Phase 1, Phase 2 Novel Antiviral Drug;Placebo
6 HSV Seroprevalence and Diagnosis of Genital Herpes in Pregnant Women Completed NCT00291044
7 A Study of HSV Testing Among Pregnant Women Terminated NCT00194415 Not Applicable

Search NIH Clinical Center for Neonatal Herpes

Genetic Tests for Neonatal Herpes

Anatomical Context for Neonatal Herpes

MalaCards organs/tissues related to Neonatal Herpes:

41
Skin, Eye, Liver, Brain, Lung, Testes, Breast

Publications for Neonatal Herpes

Articles related to Neonatal Herpes:

(show top 50) (show all 344)
# Title Authors Year
1
Neonatal herpes simplex virus infections. ( 29544668 )
2018
2
Update on Neonatal Herpes Simplex Epidemiology in the Netherlands: A Health Problem of Increasing Concern? ( 29356762 )
2018
3
Premature Termination of Treatment in Neonatal Herpes Simplex Virus Encephalitis. ( 29174006 )
2018
4
Incontinentia Pigmenti Misdiagnosed as Neonatal Herpes Simplex Virus Infection. ( 30009071 )
2018
5
Sixty seconds on . . . neonatal herpes. ( 30209054 )
2018
6
Neonatal Herpes Simplex Viral Infections and Acyclovir: An Update. ( 28469532 )
2017
7
Disseminated Neonatal Herpes Simplex Virus Infection with Escherichia Coli Coinfection. ( 28678413 )
2017
8
Why neonatal herpes matters. ( 28153515 )
2017
9
Effectiveness of Early Antiviral Therapy in Disseminated Neonatal Herpes Simplex Virus 2 (HSV-2) with Fulminant Hepatic Failure. ( 28392553 )
2017
10
Disseminated Neonatal Herpes Simplex Virus Type 1 After a Water Birth. ( 28510692 )
2017
11
Preventing neonatal herpes infections through maternal immunization. ( 29339967 )
2017
12
First estimates of the global and regional incidence of neonatal herpes infection. ( 28153513 )
2017
13
Fatal disseminated neonatal herpes simplex virus type 1 infection in neonates in a forensic setting. ( 28101751 )
2017
14
Diagnostic Pitfalls of Neonatal Herpes Infection. ( 26955143 )
2016
15
Testing and Empiric Treatment for Neonatal Herpes Simplex Virus: Challenges and Opportunities for Improving the Value of Care. ( 26740558 )
2016
16
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
17
Biting Cousins-Disseminated Neonatal Herpes Simplex Virus Infection from a Human Bite. ( 26581494 )
2016
18
Safety of High-Dose Acyclovir in Infants with Suspected and Confirmed Neonatal Herpes Simplex Virus Infections. ( 27977557 )
2016
19
Initial Presentation of Neonatal Herpes Simplex Virus Infection. ( 26960921 )
2016
20
Cutaneous neonatal herpes simplex virus infection type 2: a case report. ( 27192523 )
2016
21
Neonatal Herpes Simplex Virus Infection. ( 26154662 )
2015
22
Massive Ferritin Elevation in Neonatal Herpes Simplex Virus Infection: Hemophagocytic Lymphohistiocytosis or Herpes Simplex Virus Alone? ( 26407444 )
2015
23
Neonatal herpes simplex virus infection: epidemiology and treatment. ( 25677996 )
2015
24
Fatal Neonatal Herpes Simplex Infection Likely from Unrecognized Breast Lesions. ( 26185119 )
2015
25
Neonatal Herpes Simplex Virus Type 1 Infection and Jewish Ritual Circumcision With Oral Suction: A Systematic Review. ( 26407411 )
2015
26
Recontact and Recruitment of Young Adults Previously Enrolled in Neonatal Herpes Simplex Virus Research. ( 26479108 )
2015
27
Neonatal Herpes Infection Associated With Direct Orogenital Suction During Ritual Jewish Circumcision. ( 26407435 )
2015
28
Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. ( 26390826 )
2015
29
Challenges in the care of young infants with suspected neonatal herpes simplex virus. ( 25646205 )
2015
30
Response to Recent Review of Literature on Transmission of Neonatal Herpes Through Ritual Circumcision With Oral Suction. ( 26407436 )
2015
31
The Mortality of Neonatal Herpes Simplex Virus Infection. ( 25868428 )
2015
32
Editorial Comment: Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611873 )
2014
33
Population-based surveillance of neonatal herpes simplex virus infection in Australia, 1997-2011. ( 24846638 )
2014
34
Diffusion-weighted MRI for early diagnosis of neonatal herpes simplex encephalitis. ( 25149136 )
2014
35
Prolonged maternal postpartum fever and neonatal herpes infection. ( 25179382 )
2014
36
Prevention and management of neonatal herpes simplex virus infections. ( 24855418 )
2014
37
Safety of alternative antiviral agents for neonatal herpes simplex virus encephalitis and disseminated infection. ( 25024666 )
2014
38
Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease with Acute Retinal Necrosis. ( 24378951 )
2014
39
Clinical and neuroimaging findings in neonatal herpes simplex virusA infection. ( 24929330 )
2014
40
Neonatal herpes infections in The Netherlands in the period 2006-2011. ( 25014318 )
2014
41
Hospitalization Cost per Case of Neonatal Herpes Simplex Virus Infection From Claims Data. ( 25193688 )
2014
42
The incidence and presentation of neonatal herpes in a single UK tertiary centre, 2006-2013. ( 24919712 )
2014
43
Possible Neonatal Herpes Simplex Virus (HSV) Acquired Postpartum from Maternal Oral HSV Reactivation after Neuraxial Morphine. ( 25611872 )
2014
44
Management of neonatal herpes simplex virus infection and exposure. ( 24589428 )
2014
45
Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes. ( 26625375 )
2014
46
Neonatal herpes simplex virus presenting with isolated liver failure. ( 26839769 )
2014
47
Neonatal herpes simplex 2 infection presenting with supraglottitis. ( 23709315 )
2013
48
The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention. ( 23606868 )
2013
49
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. ( 23111154 )
2013
50
Maternal and neonatal herpes simplex virus infections. ( 23303485 )
2013

Variations for Neonatal Herpes

Expression for Neonatal Herpes

Search GEO for disease gene expression data for Neonatal Herpes.

Pathways for Neonatal Herpes

GO Terms for Neonatal Herpes

Sources for Neonatal Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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