MCID: NNT033
MIFTS: 48

Neonatal Hypoxic and Ischemic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 60
Hypoxic-Ischemic Encephalopathy 60 74
Perinatal Asphyxia 60 74
Perinatal Hypoxia 60 74
Hypoxic and Ischemic Brain Injury in the Newborn 60
Encephalopathies Hypoxic-Ischemic 56
Hypoxic Ischemic Encephalopathy 6
Hie 60

Characteristics:

Orphanet epidemiological data:

60
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 P11.1
UMLS via Orphanet 75 C0752304
Orphanet 60 ORPHA137577

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to brain injury and cardiac arrest. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, cervix and neutrophil, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.7 BDNF ENO2 MBP
2 cardiac arrest 30.2 CKB ENO2
3 status epilepticus 29.6 BDNF ENO2 PVALB
4 lennox-gastaut syndrome 11.4
5 cerebral palsy, spastic quadriplegic, 1 11.3
6 asphyxia neonatorum 11.3
7 encephalopathy 10.6
8 seizure disorder 10.6
9 epilepsy 10.4
10 cerebral palsy 10.4
11 hypoxia 10.3
12 yemenite deaf-blind hypopigmentation syndrome 10.3
13 west syndrome 10.3
14 metabolic acidosis 10.3
15 cortical blindness 10.3
16 heparin-induced thrombocytopenia 10.3
17 finger agnosia 10.2 ENO2 MBP
18 pulmonary hypertension 10.2
19 neonatal stroke 10.2
20 ischemia 10.2
21 microcephaly 10.2
22 streptococcal group a invasive disease 10.2
23 thrombocytopenia 10.2
24 cholestasis 10.2
25 neuroaxonal dystrophy 10.2 ENO2 MBP
26 juvenile pilocytic astrocytoma 10.2 ENO2 MBP
27 optic nerve glioma 10.1 ENO2 MBP
28 intraocular retinoblastoma 10.1 ENO2 PVALB
29 brainstem auditory evoked responses 10.1
30 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0 MBP TH
31 diaphragmatic hernia, congenital 10.0
32 stroke, ischemic 10.0
33 sickle cell anemia 10.0
34 myocardial infarction 10.0
35 acute myocardial infarction 10.0
36 muscle disorders 10.0
37 pain agnosia 10.0
38 molybdenum cofactor deficiency 10.0
39 heart disease 10.0
40 periventricular leukomalacia 10.0
41 capillary leak syndrome 10.0
42 thrombophilia 10.0
43 retinal vascular disease 10.0
44 epidermolysis bullosa 10.0
45 nemaline myopathy 10.0
46 placental insufficiency 10.0
47 hyperglycemia 10.0
48 myopathy 10.0
49 paraplegia 10.0
50 subacute delirium 10.0

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

GenomeRNAi Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 BDNF CKB MBP PVALB SLC1A3

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.73 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.7 BDNF CKB ENO2 MBP PVALB SLC1A3
4 no phenotypic analysis MP:0003012 9.26 BDNF PVALB SLC1A3 TH
5 vision/eye MP:0005391 9.02 BDNF MBP PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 62-31-7, 51-61-6 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
4
Tranexamic Acid Approved Phase 4 1197-18-8 5526
5
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 54670067 5785
8 Tocotrienol Investigational Phase 4 6829-55-6
9 Cardiotonic Agents Phase 4
10 Dihydroxyphenylalanine Phase 4
11 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
12 Dopamine Agents Phase 4,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
14 Sympathomimetics Phase 4
15 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable
16 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Carbidopa, levodopa drug combination Phase 4
18 Hematinics Phase 4,Phase 3,Phase 1,Phase 2
19 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
20 Trace Elements Phase 4,Not Applicable
21 Tocotrienols Phase 4
22 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
23 Micronutrients Phase 4,Not Applicable
24 Tocopherols Phase 4
25 Nutrients Phase 4,Not Applicable
26 Vaccines Phase 4
27 Antifibrinolytic Agents Phase 4
28 Hemostatics Phase 4
29 Coagulants Phase 4
30 Iron Supplement Phase 4
31 Iron-Dextran Complex Phase 4
32 Dextrans Phase 4
33 Plasma Substitutes Phase 4
34 Blood Substitutes Phase 4
35 Anticoagulants Phase 4,Phase 3,Phase 1
36
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3,Phase 2 7487-88-9 24083
37
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
38
tannic acid Approved Phase 3,Not Applicable 1401-55-4
39
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
40
Aspirin Approved, Vet_approved Phase 3,Phase 2 50-78-2 2244
41
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
42
Allopurinol Approved Phase 3 315-30-0 2094
43
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-23-7 5754
44
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3,Not Applicable 50-03-3
45
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
46
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
47
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
48
Dalteparin Approved Phase 3 9005-49-6
49
Povidone Approved Phase 3 9003-39-8
50
Titanium dioxide Approved Phase 3 13463-67-7

Interventional clinical trials:

(show top 50) (show all 153)
# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
3 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
4 Prevention of Postpartum Hemorrhage With TXA Recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
5 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
6 Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy Unknown status NCT01732146 Phase 3 erythropoietin Beta;Placebo
7 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
8 Supreme-LMA for Neonatal Resuscitation: a Prospective, Randomized Single-center Study Unknown status NCT01963936 Phase 3
9 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
10 Late Hypothermia for Hypoxic-Ischemic Encephalopathy Completed NCT00614744 Phase 2, Phase 3
11 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
12 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
13 Hypothermia Enhanced by Magnesium Sulphate Completed NCT02499393 Phase 2, Phase 3 Magnesium Sulfate
14 High Dose of Erythropoietin Analogue After Cardiac Arrest Completed NCT00999583 Phase 3 EPOETINE ALPHA
15 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
16 PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
17 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3 citicoline
18 Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
19 Preemie Hypothermia for Neonatal Encephalopathy Recruiting NCT01793129 Phase 2, Phase 3
20 CEUS Evaluation of Hypoxic Ischemic Injury Recruiting NCT03549520 Phase 3 Sulfur hexafluoride lipid-type A microspheres
21 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
22 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Active, not recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
23 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
24 Umbilical Cord Milking in Neonates Who Are Depressed at Birth Not yet recruiting NCT03657394 Phase 3
25 Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. Not yet recruiting NCT03324139 Phase 3 Low molecular weight heparin;Placebos
26 IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes Not yet recruiting NCT03574909 Phase 3 Aspirin;Placebos
27 Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Terminated NCT01192776 Phase 3
28 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
29 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
30 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Unknown status NCT01545271 Phase 1, Phase 2 xenon gas
31 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
32 Whole Body Cooling Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
33 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
34 Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy Completed NCT01059461 Phase 2 Cerebrolysin®
35 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
36 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
37 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
38 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
39 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
40 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
41 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
42 NEMO1:NEonatal Seizure Using Medication Off-patent Completed NCT01434225 Phase 1, Phase 2 Bumetanide
43 Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population Completed NCT02227056 Phase 2 Methylphenidate
44 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
45 Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Recruiting NCT01765218 Phase 1, Phase 2 Topiramate;Placebo
46 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Recruiting NCT02612155 Phase 2
47 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Recruiting NCT02071394 Phase 2 Xenon gas
48 Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study Recruiting NCT02229123 Phase 2 Intravenous Levetiracetam
49 Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy Recruiting NCT02551003 Phase 1, Phase 2 Autologous cord blood
50 Mild Encephalopathy in the Newborn Treated With Darbepoetin Recruiting NCT03071861 Phase 2 Darbepoetin Alfa;Normal Saline

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

42
Brain, Cervix, Neutrophil, Uterus, Placenta, Testes, Temporal Lobe

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 899)
# Title Authors Year
1
Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy. ( 30178266 )
2019
2
Implementation of Neonatal Neurocritical Care Program Improved Short-Term Outcomes in Neonates With Moderate-to-Severe Hypoxic Ischemic Encephalopathy. ( 31047757 )
2019
3
Effect of carbamylated erythropoietin on neuronal apoptosis in fetal rats during intrauterine hypoxic-ischemic encephalopathy. ( 31084604 )
2019
4
Parental participation during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. ( 31084824 )
2019
5
Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial. ( 31091527 )
2019
6
Prevention of excessive hypothermia in infants with hypoxic ischemic encephalopathy prior to admission to a quaternary care center: a neonatal outreach educational project. ( 31092886 )
2019
7
Potential protective effects of bilirubin following the treatment of neonatal hypoxic-ischemic encephalopathy with hypothermia therapy. ( 31101685 )
2019
8
Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-Ischemic encephalopathy. ( 31109892 )
2019
9
Factors associated with neonatal hypoxic ischemic encephalopathy in infants with an umbilical artery pH less than 7.00. ( 30884338 )
2019
10
Current Practice of Therapeutic Hypothermia for Mild Hypoxic Ischemic Encephalopathy. ( 30898007 )
2019
11
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy. ( 30909283 )
2019
12
PKM2 Involved in Neuronal Apoptosis on Hypoxic-ischemic Encephalopathy in Neonatal Rats. ( 30911983 )
2019
13
The correlation between AGT gene polymorphism and neonatal hypoxic-ischemic encephalopathy (HIE). ( 30915766 )
2019
14
Early proton magnetic resonance spectroscopy during and after therapeutic hypothermia in perinatal hypoxic-ischemic encephalopathy. ( 30918993 )
2019
15
Comparative Effects of Monosialoganglioside versus Citicoline on Apoptotic Factor, Neurological Function and Oxidative Stress in Newborns with Hypoxic-Ischemic Encephalopathy. ( 30925953 )
2019
16
Platycodin D protects cortical neurons against oxygen-glucose deprivation/reperfusion in neonatal hypoxic-ischemic encephalopathy. ( 30945345 )
2019
17
Correction: Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy. ( 30962583 )
2019
18
Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures. ( 30966848 )
2019
19
A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn. ( 30968010 )
2019
20
Acylcarnitine profile in neonatal hypoxic-ischemic encephalopathy: The value of butyrylcarnitine as a prognostic marker. ( 30985723 )
2019
21
Mechanism and Treatment Related to Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy. ( 31031592 )
2019
22
Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23/CAMKK2/AMPK pathway in neonatal hypoxic-ischemic encephalopathy. ( 30718467 )
2019
23
Monitoring Gas Exchange During Hypothermia for Hypoxic-Ischemic Encephalopathy. ( 30720647 )
2019
24
Anthropometric measures as biomarkers of neurodevelopmental outcomes of newborns with moderate to severe hypoxic ischemic encephalopathy. ( 30741696 )
2019
25
Placental findings among newborns with hypoxic ischemic encephalopathy. ( 30770878 )
2019
26
Erythropoietin in perinatal hypoxic-ischemic encephalopathy: a systematic review and meta-analysis. ( 30789826 )
2019
27
Functional Connectivity in Term Neonates With Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia. ( 30792031 )
2019
28
Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs. ( 30813933 )
2019
29
Study on serum Tau protein level and neurodevelopmental outcome of placental abruption with neonatal hypoxic-ischemic encephalopathy. ( 30821182 )
2019
30
In-hospital outcomes of neonates with hypoxic-ischemic encephalopathy receiving extracorporeal membrane oxygenation. ( 30842551 )
2019
31
Respiratory management during therapeutic hypothermia for hypoxic-ischemic encephalopathy. ( 30858610 )
2019
32
Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia. ( 30609430 )
2019
33
Combination therapy with erythropoietin, magnesium sulfate and hypothermia for hypoxic-ischemic encephalopathy: an open-label pilot study to assess the safety and feasibility. ( 30621649 )
2019
34
Resting-state network complexity and magnitude changes in neonates with severe hypoxic ischemic encephalopathy. ( 30632504 )
2019
35
Therapeutic Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy. ( 30637551 )
2019
36
Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy. ( 30639607 )
2019
37
Lack of Variability in Cerebral Oximetry Tendency in Infants with Severe Hypoxic-Ischemic Encephalopathy Under Hypothermia. ( 30676288 )
2019
38
Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. ( 30682787 )
2019
39
Prognostic Value of Electroencephalography in Hypothermia-Treated Neonates With Hypoxic-Ischemic Encephalopathy: A Meta-Analysis. ( 30691779 )
2019
40
Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy". ( 30381139 )
2019
41
Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: a feasibility study using magnetic resonance imaging. ( 30402807 )
2019
42
The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic-Ischemic Encephalopathy. ( 30325083 )
2019
43
Factors influencing decision-making: Delayed hypothermia in a late preterm infants with hypoxic-ischemic encephalopathy. ( 30343955 )
2019
44
The neurorestorative effect of human amniotic fluid stem cells on the chronic phase of neonatal hypoxic-ischemic encephalopathy in mice. ( 30120407 )
2019
45
Apgar Scores at 10 Minutes and Outcomes in Term and Late Preterm Neonates with Hypoxic-Ischemic Encephalopathy in the Cooling Era. ( 30208498 )
2019
46
Automated EEG background analysis to identify neonates with hypoxic-ischemic encephalopathy treated with hypothermia at risk for adverse outcome: A pilot study. ( 29705390 )
2019
47
Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy: magnetic resonance imaging findings and neurological outcomes in a Brazilian cohort. ( 29504433 )
2019
48
Risk Factors for Neonatal Hypoxic-Ischemic Encephalopathy in the Absence of Sentinel Events. ( 29579759 )
2019
49
Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury: a pilot study. ( 30270845 )
2018
50
Early Glycemic Profile Is Associated with Brain Injury Patterns on Magnetic Resonance Imaging in Hypoxic Ischemic Encephalopathy. ( 30197201 )
2018

Variations for Neonatal Hypoxic and Ischemic Brain Injury

ClinVar genetic disease variations for Neonatal Hypoxic and Ischemic Brain Injury:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BEND2; CDKL5; RAI2; SCML2 Xp22.13(+)(18074005) complex Uncertain significance GRCh37 Chromosome X, 17793009: 18532312

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 MBP SLC1A3 TH
2 11.54 BDNF SLC1A3 TH
3 11.05 BDNF MBP
4 10.7 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.5 BDNF CKB TH
2 axon GO:0030424 9.33 BDNF PVALB TH
3 cell periphery GO:0071944 9.26 MBP SLC1A3
4 neuronal cell body GO:0043025 9.1 CKB ENO2 MBP PVALB SLC1A3 TH
5 myelin sheath GO:0043209 8.65 MBP

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.26 BDNF TH
2 substantia nigra development GO:0021762 9.16 CKB MBP
3 response to light stimulus GO:0009416 8.96 SLC1A3 TH
4 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
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18 ExPASy
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34 ICD10
35 ICD10 via Orphanet
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
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75 UMLS via Orphanet
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