HIE
MCID: NNT033
MIFTS: 47

Neonatal Hypoxic and Ischemic Brain Injury (HIE)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 59
Hypoxic-Ischemic Encephalopathy 59 73
Perinatal Asphyxia 59 73
Perinatal Hypoxia 59 73
Hypoxic and Ischemic Brain Injury in the Newborn 59
Encephalopathies Hypoxic-Ischemic 55
Hie 59

Characteristics:

Orphanet epidemiological data:

59
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA137577
ICD10 via Orphanet 34 P11.1
UMLS via Orphanet 74 C0752304

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to brain injury and cardiac arrest. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include brain, heart and kidney, and related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.8 BDNF ENO2 MBP
2 cardiac arrest 30.2 CKB ENO2
3 status epilepticus 29.7 BDNF ENO2 PVALB
4 bipolar disorder 29.1 BDNF PVALB TH
5 lennox-gastaut syndrome 11.4
6 cerebral palsy, spastic quadriplegic, 1 11.2
7 encephalopathy 10.6
8 epilepsy 10.4
9 cerebral palsy 10.4
10 seizure disorder 10.4
11 hypoxia 10.3
12 metabolic acidosis 10.3
13 cortical blindness 10.3
14 west syndrome 10.2
15 pulmonary hypertension 10.2
16 neonatal stroke 10.2
17 microcephaly 10.2
18 ischemia 10.2
19 finger agnosia 10.1 ENO2 MBP
20 neuroaxonal dystrophy 10.1 ENO2 MBP
21 juvenile pilocytic astrocytoma 10.1 ENO2 MBP
22 optic nerve glioma 10.1 ENO2 MBP
23 intraocular retinoblastoma 10.1 ENO2 PVALB
24 brainstem auditory evoked responses 10.1
25 heparin-induced thrombocytopenia 10.1
26 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.0 MBP TH
27 diaphragmatic hernia, congenital 10.0
28 stroke, ischemic 10.0
29 yemenite deaf-blind hypopigmentation syndrome 10.0
30 myocardial infarction 10.0
31 acute myocardial infarction 10.0
32 pain agnosia 10.0
33 molybdenum cofactor deficiency 10.0
34 heart disease 10.0
35 periventricular leukomalacia 10.0
36 capillary leak syndrome 10.0
37 thrombophilia 10.0
38 retinal vascular disease 10.0
39 infantile epileptic encephalopathy 10.0
40 epidermolysis bullosa 10.0
41 placental insufficiency 10.0
42 hyperglycemia 10.0
43 myopathy 10.0
44 paraplegia 10.0
45 priapism 10.0
46 acute necrotizing encephalopathy 10.0
47 leukomalacia 10.0
48 systemic capillary leak syndrome 10.0
49 depression 10.0
50 intranuclear rod myopathy 10.0

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

GenomeRNAi Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 BDNF CKB MBP PVALB SLC1A3

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.73 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.7 BDNF CKB ENO2 MBP PVALB SLC1A3
4 no phenotypic analysis MP:0003012 9.26 BDNF PVALB SLC1A3 TH
5 vision/eye MP:0005391 9.02 BDNF MBP PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Search Clinical Trials , NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

41
Brain, Heart, Kidney, Testes, Placenta, Lung, Temporal Lobe

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 852)
# Title Authors Year
1
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLRa894a89mediated NFa89I_B signal pathway. ( 29956801 )
2018
2
Obstetric emergencies as antecedents to neonatal hypoxic ischemic encephalopathy, does parity matter? ( 29978451 )
2018
3
Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies. ( 29432237 )
2018
4
Antepartum risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy: a Swedish national cohort study. ( 29450878 )
2018
5
Brain cooling reduces the risk of post-neonatal epilepsy in newborns affected by moderate to severe hypoxic-ischemic encephalopathy. ( 29968450 )
2018
6
Late failure of cerebral autoregulation in hypoxic-ischemic encephalopathy is associated with brain injury: a pilot study. ( 30270845 )
2018
7
Early Glycemic Profile Is Associated with Brain Injury Patterns on Magnetic Resonance Imaging in Hypoxic Ischemic Encephalopathy. ( 30197201 )
2018
8
Transorbital Sonography for Early Prognostication of Hypoxic-Ischemic Encephalopathy After Cardiac Arrest. ( 29883008 )
2018
9
Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy. ( 30178266 )
2018
10
Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy. ( 29063960 )
2018
11
Delayed cortical blindness in hypoxic-ischemic encephalopathy. ( 30505959 )
2018
12
Magnetic Resonance Imaging Findings of Term and Preterm Hypoxic-Ischemic Encephalopathy: A Review of Relevant Animal Models and Correlation to Human Imaging. ( 30450146 )
2018
13
Analysis of long noncoding RNA expression profiles in the whole blood of neonates with hypoxic-ischemic encephalopathy. ( 30474258 )
2018
14
MR Imaging of hypoxic ischemic encephalopathy - Distribution Patterns and ADC value correlations. ( 30480058 )
2018
15
A Pilot Study of Soluble Form of LOX-1 as a Novel Biomarker for Neonatal Hypoxic-Ischemic Encephalopathy. ( 30553539 )
2018
16
Subcutaneous Fat Necrosis and Hypercalcemia After Therapeutic Hypothermia in Patients With Hypoxic-ischemic Encephalopathy: A Case Series. ( 30280069 )
2018
17
Repurposing of dexpramipexole to treatment of neonatal hypoxic/ischemic encephalopathy. ( 30287306 )
2018
18
A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. ( 30296665 )
2018
19
The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic-Ischemic Encephalopathy. ( 30325083 )
2018
20
Factors influencing decision-making: Delayed hypothermia in a late preterm infants with hypoxic-ischemic encephalopathy. ( 30343955 )
2018
21
Seizures in newborn infants without hypoxic ischemic encephalopathy - antenatal and labor-related risk factors: a case-control study. ( 30373414 )
2018
22
Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy". ( 30381139 )
2018
23
Cerebral oxygen metabolism during and after therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: a feasibility study using magnetic resonance imaging. ( 30402807 )
2018
24
Perinatal Hypoxic-Ischemic Encephalopathy and Neuroprotective Peptide Therapies: A Case for Cationic Arginine-Rich Peptides (CARPs). ( 30087289 )
2018
25
Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants. ( 30089504 )
2018
26
Novel structured MRI reporting system in neonatal hypoxic-ischemic encephalopathy - issues of development and first use experiences. ( 30113795 )
2018
27
The neurorestorative effect of human amniotic fluid stem cells on the chronic phase of neonatal hypoxic-ischemic encephalopathy in mice. ( 30120407 )
2018
28
Predictive Value of Thompson-Score for Long-Term Neurological and Cognitive Outcome in Term Newborns with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy Undergoing Controlled Hypothermia Treatment. ( 30130752 )
2018
29
Identification of a panel of cytokines in neonates with hypoxic ischemic encephalopathy treated with hypothermia. ( 30142532 )
2018
30
Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy. ( 30144709 )
2018
31
Wharton's Jelly-Derived Mesenchymal Stem Cell Transplantation in a Patient with Hypoxic-Ischemic Encephalopathy: A Pilot Study. ( 30203688 )
2018
32
Does fluid restriction improve outcomes in infants with hypoxic ischemic encephalopathy? A pilot randomized controlled trial. ( 30206346 )
2018
33
Apgar Scores at 10 Minutes and Outcomes in Term and Late Preterm Neonates with Hypoxic-Ischemic Encephalopathy in the Cooling Era. ( 30208498 )
2018
34
Neonatal encephalopathy versus Hypoxic-Ischemic Encephalopathy. ( 30214023 )
2018
35
High electroencephalographic seizure exposure is associated with unfavorable outcomes in neonates with hypoxic-ischemic encephalopathy. ( 30227341 )
2018
36
Serum calcium derangements in neonates with moderate to severe hypoxic ischemic encephalopathy and the impact of therapeutic hypothermia: a cohort study. ( 30231649 )
2018
37
Changes in bilirubin in infants with hypoxic-ischemic encephalopathy. ( 30232591 )
2018
38
Proton Magnetic Resonance Spectroscopy Biomarkers in Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review and Meta-Analysis. ( 30233483 )
2018
39
Antenatal and Intrapartum Risk Factors for Hypoxic-Ischemic Encephalopathy in a US Birth Cohort. ( 30270166 )
2018
40
The maximum value of bispectral index predicts outcome in hypoxic-ischemic encephalopathy after resuscitation, better than minimum or mean value. ( 29851509 )
2018
41
Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy. ( 29863263 )
2018
42
Renal Saturation and Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia. ( 29866591 )
2018
43
Cerebral Lactate Concentration in Neonatal Hypoxic-Ischemic Encephalopathy: In Relation to Time, Characteristic of Injury, and Serum Lactate Concentration. ( 29867713 )
2018
44
Early Detection of Hypothermic Neuroprotection Using T2-Weighted Magnetic Resonance Imaging in a Mouse Model of Hypoxic Ischemic Encephalopathy. ( 29867720 )
2018
45
Xenon Combined With Hypothermia in Perinatal Hypoxic-Ischemic Encephalopathy: A Noble Gas, a Noble Mission. ( 29887039 )
2018
46
Changes in Brain Metabolite Concentrations after Neonatal Hypoxic-ischemic Encephalopathy. ( 29893645 )
2018
47
Predictive value of early EEG for seizures in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. ( 29895836 )
2018
48
Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy. ( 29907863 )
2018
49
Bone Morphogenetic Protein (BMP)-3b Gene Depletion Causes High Mortality in a Mouse Model of Neonatal Hypoxic-Ischemic Encephalopathy. ( 29922215 )
2018
50
Severity of hypoxic ischemic encephalopathy correlates with increased expression of angiogenin in neonates. ( 29991143 )
2018

Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 MBP SLC1A3 TH
2 11.54 BDNF SLC1A3 TH
3 11.05 BDNF MBP
4 10.7 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.5 BDNF CKB TH
2 axon GO:0030424 9.33 BDNF PVALB TH
3 cell periphery GO:0071944 9.26 MBP SLC1A3
4 myelin sheath GO:0043209 9.13 CKB ENO2 MBP
5 neuronal cell body GO:0043025 9.1 CKB ENO2 MBP PVALB SLC1A3 TH

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.26 BDNF TH
2 substantia nigra development GO:0021762 9.16 CKB MBP
3 response to light stimulus GO:0009416 8.96 SLC1A3 TH
4 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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