MCID: NNT033
MIFTS: 43

Neonatal Hypoxic and Ischemic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 59
Hypoxic-Ischemic Encephalopathy 59 73
Perinatal Asphyxia 59 73
Perinatal Hypoxia 59 73
Hypoxic and Ischemic Brain Injury in the Newborn 59
Encephalopathies Hypoxic-Ischemic 55
Hie 59

Characteristics:

Orphanet epidemiological data:

59
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA137577
ICD10 via Orphanet 34 P11.1
UMLS via Orphanet 74 C0752304

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to lennox-gastaut syndrome and cerebral palsy, spastic quadriplegic, 1. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and cervix, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 lennox-gastaut syndrome 11.2
2 cerebral palsy, spastic quadriplegic, 1 11.1
3 asphyxia neonatorum 11.1
4 finger agnosia 10.4 ENO2 MBP
5 juvenile pilocytic astrocytoma 10.4 ENO2 MBP
6 optic nerve glioma 10.4 ENO2 MBP
7 secondary progressive multiple sclerosis 10.3 ENO2 MBP
8 hypoxia 10.3
9 intraocular retinoblastoma 10.3 ENO2 PVALB
10 cardiac arrest 10.2 CKB ENO2
11 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.1 MBP TH
12 rhabdomyosarcoma 2 10.1 ENO2 TH
13 neuronitis 10.1
14 multiple system atrophy 1 10.0 MBP TH
15 hyperphenylalaninemia 10.0 MBP TH
16 ischemia 10.0
17 nodular ganglioneuroblastoma 10.0 BDNF ENO2
18 oligodendroglioma 10.0 ENO2 MBP
19 encephalopathy 9.9
20 supranuclear palsy, progressive, 1 9.9 PVALB TH
21 childhood disintegrative disease 9.9 BDNF MBP
22 sturge-weber syndrome 9.8
23 hemolytic uremic syndrome, atypical 1 9.8
24 cerebral palsy 9.8
25 dyskinetic cerebral palsy 9.8
26 chorioamnionitis 9.8
27 hemolytic-uremic syndrome 9.8
28 intestinal perforation 9.8
29 kernicterus 9.8
30 cerebritis 9.8
31 weber syndrome 9.8
32 meningoencephalitis 9.8 BDNF MBP
33 relapsing-remitting multiple sclerosis 9.7 BDNF MBP
34 tendinosis 9.7 BDNF TH
35 neuronal ceroid-lipofuscinoses 9.7 MBP PVALB SLC1A3
36 early-onset schizophrenia 9.6 BDNF TH
37 toxic encephalopathy 9.6 BDNF TH
38 disease of mental health 9.5 BDNF PVALB
39 central hypoventilation syndrome, congenital 9.5 BDNF TH
40 traumatic brain injury 9.5 BDNF ENO2 MBP
41 brain injury 9.5 BDNF ENO2 MBP
42 west syndrome 9.5 PVALB TH
43 gilles de la tourette syndrome 9.4 BDNF SLC1A3
44 status epilepticus 9.4 BDNF ENO2 PVALB
45 peripheral nervous system neoplasm 9.3 BDNF ENO2 TH
46 autonomic nervous system neoplasm 9.3 BDNF ENO2 TH
47 temporal lobe epilepsy 9.2 BDNF PVALB SLC1A3
48 central nervous system disease 9.2 BDNF MBP TH
49 nervous system disease 9.1 BDNF MBP TH
50 synucleinopathy 9.1 BDNF PVALB TH

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.63 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.5 MBP PVALB SLC1A3 TH BDNF CKB
4 no phenotypic analysis MP:0003012 8.92 BDNF PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Tranexamic Acid Approved Phase 4 1197-18-8 5526
4
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 5785 54670067
5
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable
8 Dihydroxyphenylalanine Phase 4
9 Dopamine Agents Phase 4,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
11 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
13 Carbidopa, levodopa drug combination Phase 4
14 Micronutrients Phase 4,Not Applicable
15 Tocopherols Phase 4
16 Tocotrienols Phase 4
17 Trace Elements Phase 4,Not Applicable
18 Vaccines Phase 4
19 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
20 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
21 Coagulants Phase 4
22 Hemostatics Phase 4
23 Antifibrinolytic Agents Phase 4
24 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
25
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
26
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3,Phase 2 7487-88-9 24083
27
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
28
Allopurinol Approved Phase 3 315-30-0 2094
29
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
30
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
31
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
32
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
33
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
34
Dalteparin Approved Phase 3 9005-49-6
35 tannic acid Approved, Nutraceutical Phase 3,Not Applicable
36
Choline Approved, Nutraceutical Phase 3 62-49-7 305
37
Butyric Acid Experimental, Investigational Phase 2, Phase 3 107-92-6 264
38 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
39 Analgesics Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
40 calcium channel blockers Phase 3,Phase 2
41 Central Nervous System Depressants Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
42 Hematinics Phase 3,Phase 1,Phase 2
43 Tocolytic Agents Phase 3,Phase 2
44 Anesthetics Phase 3,Phase 2,Phase 1,Not Applicable
45 Anti-Arrhythmia Agents Phase 3,Phase 2
46 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
47 Anticonvulsants Phase 3,Phase 2,Phase 1,Not Applicable
48 Calcium, Dietary Phase 3,Phase 2
49 Progestins Phase 2, Phase 3
50 diuretics Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 135)
# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
3 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
4 Prevention of Postpartum Hemorrhage With TXA Recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
5 Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial Recruiting NCT03438227 Phase 4 Iron dextran;Ferrous sulfate 325mg
6 Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy Unknown status NCT01732146 Phase 3 erythropoietin Beta;Placebo
7 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
8 Supreme-LMA for Neonatal Resuscitation: a Prospective, Randomized Single-center Study Unknown status NCT01963936 Phase 3
9 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
10 Late Hypothermia for Hypoxic-Ischemic Encephalopathy Completed NCT00614744 Phase 2, Phase 3
11 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
12 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
13 Hypothermia Enhanced by Magnesium Sulphate Completed NCT02499393 Phase 2, Phase 3 Magnesium Sulfate
14 High Dose of Erythropoietin Analogue After Cardiac Arrest Completed NCT00999583 Phase 3 EPOETINE ALPHA
15 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
16 PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
17 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3 citicoline
18 Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
19 Preemie Hypothermia for Neonatal Encephalopathy Recruiting NCT01793129 Phase 2, Phase 3
20 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
21 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Active, not recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
22 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
23 CEUS Evaluation of Hypoxic Ischemic Injury Not yet recruiting NCT03549520 Phase 3 Sulfur hexafluoride lipid-type A microspheres
24 Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. Not yet recruiting NCT03324139 Phase 3 Low molecular weight heparin;Placebos
25 IRELAnD: Investigating the Role of Early Low-dose Aspirin in Diabetes Not yet recruiting NCT03574909 Phase 3 Aspirin;Placebos
26 Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Terminated NCT01192776 Phase 3
27 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
28 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Unknown status NCT01545271 Phase 1, Phase 2 xenon gas
29 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
30 Whole Body Cooling Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
31 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
32 Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy Completed NCT01059461 Phase 2 Cerebrolysin®
33 Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Completed NCT01765218 Phase 1, Phase 2 Topiramate;Placebo
34 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
35 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
36 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
37 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
38 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
39 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
40 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
41 NEMO1:NEonatal Seizure Using Medication Off-patent Completed NCT01434225 Phase 1, Phase 2 Bumetanide
42 Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation Completed NCT01616615 Phase 2 Aspirin;placebo
43 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Recruiting NCT02612155 Phase 2
44 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Recruiting NCT02071394 Phase 2 Xenon gas
45 Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study Recruiting NCT02229123 Phase 2 Intravenous Levetiracetam
46 Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy Recruiting NCT02551003 Phase 1, Phase 2 Autologous cord blood
47 Mild Encephalopathy in the Newborn Treated With Darbepoetin Recruiting NCT03071861 Phase 2 Darbepoetin Alfa;Normal Saline
48 TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA Recruiting NCT02836340 Phase 1, Phase 2 2-Iminobiotin
49 Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population Recruiting NCT02227056 Phase 2 Methylphenidate
50 Erythropoietin in Premature Infants to Prevent Encephalopathy Recruiting NCT02550054 Phase 2 Epo;Normal saline

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

41
Brain, Heart, Cervix, Neutrophil, Placenta, Uterus, Endothelial

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 72)
# Title Authors Year
1
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLRa894a89mediated NFa89I_B signal pathway. ( 29956801 )
2018
2
Obstetric emergencies as antecedents to neonatal hypoxic ischemic encephalopathy, does parity matter? ( 29978451 )
2018
3
Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies. ( 29432237 )
2018
4
Antepartum risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy: a Swedish national cohort study. ( 29450878 )
2018
5
Brain cooling reduces the risk of post-neonatal epilepsy in newborns affected by moderate to severe hypoxic-ischemic encephalopathy. ( 29968450 )
2018
6
Benefits of starting hypothermia treatment within 6A h vs. 6-12A h in newborns with moderate neonatal hypoxic-ischemic encephalopathy. ( 29433475 )
2018
7
Predictive value of amplitude-integrated EEG (aEEG) after rescue hypothermic neuroprotection for hypoxic ischemic encephalopathy: a meta-analysis. ( 28252661 )
2017
8
Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies. ( 29261798 )
2017
9
The Neuroprotective Strategic Analysis for Patients with Acute Myocardial Infarction Combined with Hypoxic Ischemic Encephalopathy in ICU. ( 28065791 )
2017
10
Delayed Transient Cortical Blindness from Hypoxic Ischemic Encephalopathy. ( 28390792 )
2017
11
Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy. ( 28938291 )
2017
12
Protein S100B in umbilical cord blood as a potential biomarker of hypoxic-ischemic encephalopathy in asphyxiated newborns. ( 28756088 )
2017
13
The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate. ( 28942555 )
2017
14
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
15
The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population. ( 28070505 )
2016
16
Perinatal inflammation/infection and its association with correction of metabolic acidosis in hypoxic-ischemic encephalopathy. ( 26796123 )
2016
17
Hypoxic-Ischemic Encephalopathy and Serum Magnesium Monitoring and Maintenance. ( 27194611 )
2016
18
Comparison of Passive and Servo-Controlled Active Cooling for Infants with Hypoxic-Ischemic Encephalopathy during Neonatal Transfers. ( 27182995 )
2016
19
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
20
Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy. ( 27647155 )
2016
21
Erythropoietin improves hypoxic-ischemic encephalopathy in Neonatal Rats after Short-term Anoxia by Enhancing Angiogenesis. ( 27659964 )
2016
22
The therapeutic effect of CD133(+) cells derived from human umbilical cord blood on neonatal mouse hypoxic-ischemic encephalopathy model. ( 27287679 )
2016
23
Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy. ( 27197831 )
2016
24
Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy. ( 27650049 )
2016
25
Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy. ( 26135781 )
2016
26
Therapeutic hypothermia for infants with hypoxic ischemic encephalopathy: A five years' single center experience in Kuwait. ( 27197929 )
2016
27
ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. ( 26261584 )
2015
28
NF-I_B Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy. ( 26255634 )
2015
29
Serum levels of S-100I^ correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates. ( 26600537 )
2015
30
The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia. ( 26571073 )
2015
31
Impact of Thrombophilia on the Risk of Hypoxic-Ischemic Encephalopathy in Term Neonates. ( 26400660 )
2015
32
Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy. ( 26001314 )
2015
33
Dietary Interventions Designed to Protect the Perinatal Brain from Hypoxic-Ischemic Encephalopathy - Creatine Prophylaxis and The Need for Multi-Organ Protection. ( 26576837 )
2015
34
Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. ( 24322171 )
2014
35
Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy. ( 25140814 )
2014
36
Hypoxic ischemic encephalopathy in a case of intranuclear rod myopathy without any prenatal sentinel event. ( 24787270 )
2014
37
Successful Hypothermia Treatment of Hypoxic-Ischemic Encephalopathy in a Neonate with Epidermolysis Bullosa. ( 23934101 )
2013
38
Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study. ( 23392373 )
2013
39
Epilepsy and West syndrome in neonates with hypoxic-ischemic encephalopathy. ( 24274080 )
2013
40
Congenital diaphragmatic hernia repair during whole body hypothermia for neonatal hypoxic ischemic encephalopathy. ( 23190939 )
2012
41
Hypoxic-ischemic encephalopathy following vaso-occlusive crisis in hemoglobin SC disease. ( 29443262 )
2012
42
A novel SOX10 mutation in a patient with PCWH who developed hypoxic-ischemic encephalopathy after E. coli sepsis. ( 21822601 )
2011
43
Cortical blindness and paraplegia following hypoxic ischemic encephalopathy as a complication of common krait bite. ( 21876601 )
2011
44
Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy. ( 21674837 )
2011
45
Status epilepticus and capillary leak syndrome in a neonate related to perinatal hypoxic-ischemic encephalopathy. ( 20140779 )
2010
46
Prolonged EEG depression in term and near-term infants with hypoxic ischemic encephalopathy and later development of West syndrome. ( 20887363 )
2010
47
Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. ( 20036850 )
2010
48
Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term. ( 19482672 )
2009
49
Hypoxic/ischemic encephalopathy associated with placental insufficiency in a cloned foal. ( 19112119 )
2009
50
[Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy]. ( 19292949 )
2009

Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 MBP SLC1A3 TH
2 11.54 BDNF SLC1A3 TH
3 11.05 BDNF MBP
4 10.7 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.54 BDNF CKB TH
2 axon GO:0030424 9.33 BDNF PVALB TH
3 terminal bouton GO:0043195 9.32 PVALB TH
4 cell periphery GO:0071944 9.26 MBP SLC1A3
5 myelin sheath GO:0043209 9.13 CKB ENO2 MBP
6 neuronal cell body GO:0043025 9.1 CKB ENO2 MBP PVALB SLC1A3 TH

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.26 BDNF TH
2 substantia nigra development GO:0021762 9.16 CKB MBP
3 response to light stimulus GO:0009416 8.96 SLC1A3 TH
4 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

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