HIE
MCID: NNT033
MIFTS: 42

Neonatal Hypoxic and Ischemic Brain Injury (HIE)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 58
Hypoxic-Ischemic Encephalopathy 58 70
Perinatal Asphyxia 58 70
Perinatal Hypoxia 58 70
Hypoxic and Ischemic Brain Injury in the Newborn 58
Encephalopathies Hypoxic-Ischemic 54
Hypoxic Ischemic Encephalopathy 6
Hie 58

Characteristics:

Orphanet epidemiological data:

58
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 P91.6
UMLS via Orphanet 71 C0752304
Orphanet 58 ORPHA137577
UMLS 70 C0559477 C0559478 C0752304

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to asphyxia neonatorum and encephalomalacia. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Tocopherol and Vitamin C have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and placenta, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 asphyxia neonatorum 31.3 ENO2 BDNF
2 encephalomalacia 30.6 MBP BDNF
3 status epilepticus 30.5 PVALB ENO2 BDNF
4 carotid artery occlusion 30.5 MBP BDNF
5 hemiplegia 30.1 SLC1A3 ENO2
6 traumatic brain injury 30.0 MBP ENO2 BDNF
7 hydrocephalus 30.0 MBP ENO2 BDNF
8 stroke, ischemic 30.0 MBP ENO2 BDNF
9 brain injury 29.7 MBP ENO2 BDNF
10 cervical dystonia 29.6 TH BDNF
11 leukoencephalopathy, hereditary diffuse, with spheroids 29.5 SLC1A3 PVALB MBP
12 sleep disorder 29.3 TH BDNF
13 schizophrenia 28.4 TH SLC1A3 PVALB MBP BDNF
14 disease of mental health 28.1 TH SLC1A3 PVALB MBP ENO2 BDNF
15 cerebral palsy, spastic quadriplegic, 1 11.1
16 seizure disorder 10.8
17 ocular motor apraxia 10.6
18 pulmonary hypertension 10.6
19 encephalopathy 10.5
20 yemenite deaf-blind hypopigmentation syndrome 10.5
21 cardiac arrest 10.5
22 placental abruption 10.5
23 hypoglycemia 10.5
24 chorioamnionitis 10.5
25 west syndrome 10.4
26 periventricular leukomalacia 10.4
27 47,xyy 10.4
28 cytokine deficiency 10.4
29 anoxia 10.4
30 hypotonia 10.4
31 thrombocytopenia 10.4
32 epilepsy 10.4
33 cerebral hypoxia 10.4
34 branchiootic syndrome 1 10.3
35 cortical blindness 10.3
36 respiratory failure 10.3
37 quadriplegia 10.3
38 neonatal stroke 10.3
39 autonomic dysfunction 10.3
40 hypoxia 10.3
41 persistent vegetative state 10.3
42 cerebral palsy 10.2
43 cardiac arrhythmia 10.2
44 insulin-like growth factor i 10.2
45 microcephaly 10.2
46 meconium aspiration syndrome 10.2
47 toxic shock syndrome 10.2
48 hyperglycemia 10.2
49 inherited metabolic disorder 10.2
50 spasticity 10.2

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.8 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.7 BDNF CKB ENO2 MBP PVALB SLC1A3
4 hearing/vestibular/ear MP:0005377 9.56 BDNF CKB MBP SLC1A3
5 no phenotypic analysis MP:0003012 9.26 BDNF PVALB SLC1A3 TH
6 vision/eye MP:0005391 9.02 BDNF MBP PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 116)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2
2
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Tocotrienol Investigational Phase 4 6829-55-6
5 Antioxidants Phase 4
6 Protective Agents Phase 4
7 Micronutrients Phase 4
8 Trace Elements Phase 4
9 Nutrients Phase 4
10 Vitamins Phase 4
11 Tocotrienols Phase 4
12 Tocopherols Phase 4
13
Allopurinol Approved Phase 3 315-30-0 2094
14
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
15
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
16
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
17
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
18
Choline Approved, Nutraceutical Phase 3 62-49-7 305
19 Antimetabolites Phase 3
20 diuretics Phase 3
21 Nootropic Agents Phase 3
22 Epinephryl borate Phase 2, Phase 3
23 glucocorticoids Phase 2, Phase 3
24 Cytidine Diphosphate Choline Phase 3
25 Anticonvulsants Phase 3
26 Anesthetics Phase 3
27 Analgesics Phase 3
28 Anti-Arrhythmia Agents Phase 3
29 Hormones Phase 3
30 Tocolytic Agents Phase 3
31 calcium channel blockers Phase 3
32 Calcium, Dietary Phase 3
33 Hematinics Phase 3
34 Epoetin alfa Phase 3 113427-24-0
35
Calcium Nutraceutical Phase 3 7440-70-2 271
36
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
37
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
38
Darbepoetin alfa Approved, Investigational Phase 1, Phase 2 209810-58-2, 11096-26-7
39
Levetiracetam Approved Phase 2 102767-28-2 441341
40
Topiramate Approved Phase 1, Phase 2 97240-79-4 5284627
41
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
42
Morphine Approved, Investigational Phase 2 57-27-2 5288826
43
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
44
Xenon Experimental Phase 1, Phase 2 7440-63-3
45
Cerebrolysin Experimental Phase 2 12656-61-0
46 Tin Fluorides Phase 1, Phase 2
47 Anesthetics, General Phase 1, Phase 2
48 Anesthetics, Inhalation Phase 1, Phase 2
49 Vasodilator Agents Phase 1, Phase 2
50 Antihypertensive Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 The First-day High Dose Vitamin E and Vitamin C in Hypoxic Ischemic Encephalopathy (Following Birth Asphyxia) in Newborns Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
2 Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III) Unknown status NCT03162653 Phase 3 Allopurinol;Mannitol
3 Phase III Study of Efficacy of High Dose Erythropoietin to Prevent Hypoxic-ischemic Encephalopathy Sequelae in Term Newborn Unknown status NCT01732146 Phase 3 erythropoietin Beta;Placebo
4 A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
5 Prospective, Randomized, Double-blind, Cohort Study of Hydrocortisone vs Placebo in Systemic Low Blood Pressure During Hypothermia Treatment in Asphyxiated Newborns Unknown status NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
6 Effect of Erythropoietin and Hypothermia on Management of Neonatal Hypoxic Ischemic Encephalopathy Unknown status NCT03163589 Phase 3 Erythropoietin;normal saline
7 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Unknown status NCT03181646 Phase 3 citicoline
8 Selective Head Cooling With Mild Systemic Hypothermia After Neonatal Hypoxic-Ischemic Encephalopathy: A Multi-Center Randomized Controlled Trial in China Completed NCT00890409 Phase 3
9 Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants Completed NCT00005772 Phase 3
10 Magnesium Sulphate in Perinatal Asphyxia: A Randomized Placebo Controlled Trial. Completed NCT00553072 Phase 3 Magnesium sulphate;Normal saline
11 Erythropoietin in Perinatal Asphyxia: A Randomized Placebo Controlled Trial Completed NCT02002039 Phase 2, Phase 3 Erythropoietin
12 Improved Diagnosis and Prognostication of Hypoxic Ischemic Injury in Neonates and Infants Using Contrast-Enhanced Ultrasound Recruiting NCT03549520 Phase 3 Sulfur hexafluoride lipid-type A microspheres
13 Preventing Adverse Outcomes of Neonatal Hypoxic Ischaemic Encephalopathy With Erythropoietin: A Phase III Randomised Placebo Controlled Multicentre Clinical Trial Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
14 Short-term Outcomes of Umbilical Cord Milking in Term and Late Preterm Neonates Who Are Depressed at Birth Not yet recruiting NCT03657394 Phase 3
15 Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment: a Randomized, Multicentric, Blinded, Controlled Trial Not yet recruiting NCT04145713 Phase 3
16 Phase II Randomized Control Trial of Whole Body Cooling in Neonatal Encephalopathy Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
17 Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells Unknown status NCT02881970 Phase 1, Phase 2 autologous cord blood stem cell
18 Effect of Systemic Hypothermia on Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
19 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
20 Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
21 Human Recombinant Erythropoietin (HrEPO) in Asphyxia Neonatorum: A Pilot Trial Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
22 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes Study Completed NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
23 Phase 2 Nerve Growth Factor (Cerebrolysin®) for Treatment of Neonatal Hypoxic Ischemic Encephalopathy Completed NCT01059461 Phase 2 Cerebrolysin®
24 A Phase II Multi-site Study of Autologous Cord Blood Cells for Hypoxic (HIE) Completed NCT02612155 Phase 2
25 Effect of Erythropoietin on Neonatal Hypoxic Ischemic Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
26 Safety and Efficacy of Oral Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia: a Pilot Study of the Neonatal Neuroprotection of Asphyxiated Tuscan Infants (NeoNATI) Network Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
27 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
28 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
29 Beneficial Effect of Intravenous Magnesium Sulphate in Term Neonates With Hypoxic Ischemic Encephalopathy(HIE) Completed NCT04705142 Phase 2 MgSo4
30 Melatonin for Neuroprotection Following Perinatal Asphyxia Completed NCT02071160 Phase 1, Phase 2 Melatonin
31 Levetiracetam Efficacy and Safety as First-line Treatment of Neonatal Seizures Occuring in Hypoxic-ischemic Encephalopathy Context Recruiting NCT02229123 Phase 2 Intravenous Levetiracetam
32 A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy Recruiting NCT04063215 Phase 1, Phase 2 HB-adMSCs
33 A Multi-Centre Safety and Efficacy Study of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonates Encephalopathy in China Recruiting NCT02551003 Phase 1, Phase 2 Autologous cord blood
34 Topiramate as an Adjuvant to Therapeutic Hypothermia for Infants With Hypoxic Ischemic Encephalopathy Recruiting NCT01765218 Phase 1, Phase 2 Topiramate;Placebo
35 Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) Not yet recruiting NCT04772222 Phase 2 Dexmedetomidine Hydrochloride;Morphine Sulfate
36 A Multi-centre, Randomised, Double-blind, Placebo-controlled Phase II Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) in Neonates With ≥36 Weeks GA With Moderate to Severe Perinatal Asphyxia Terminated NCT01626924 Phase 2 2-Iminobiotin
37 A Safety and Feasibility Study of Autologous Cord Blood (CB) and Human Placental Derived Stem Cells (HPDSC) in Neonates With Severe Hypoxic-Ischemic Encephalopathy (HIE) Withdrawn NCT02434965 Phase 2 HPDSC;Cord blood
38 Umbilical Cord Blood Mononuclear Cell Bank in Hong Kong and Treatment of Neonatal Cerebral Ischemia and Anemia - Part IV Clinical Trial Unknown status NCT03352310 Phase 1
39 Safety and Efficacy Investigation of Patients With Hypoxic Ischemic Encephalopathy by Transplantation of Umbilical Cord Derived Mesenchymal Stem Cells Unknown status NCT01962233 Phase 1
40 Hypoxic-Ischemic Encephalopathy Therapy Optimization for Better Neuroprotection With Inhalative CO2 in Asphyxiated, Cooled, Mechanically Ventilated Neonates at Risk for Hypocapnia Unknown status NCT02700854 Phase 1
41 Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Study 1. Phase I Study of Feasibility and Safety. Completed NCT00593242 Phase 1
42 A Phase I Study of hCT-MSC, an Umbilical Cord-Derived Mesenchymal Stromal Cell Product, in Newborn Infants With Moderate or Severe Hypoxic- Ischemic Neonatal Encephalopathy. Completed NCT03635450 Phase 1
43 Neonatal Erythropoietin in Asphyxiated Term Newborns: a Phase I Trial Completed NCT00719407 Phase 1 erythropoietin
44 A Pilot Feasibility and Safety Study of Autologous Umbilical Cord Blood Cell Therapy in Infants With Neonatal Encephalopathy Completed NCT02256618 Phase 1
45 Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy: Phase I Study of Feasibility and Safety Completed NCT01649648 Phase 1
46 IRB# 070984 "Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy" Completed NCT00620711 Phase 1
47 Pharmacokinetics and Safety of Caffeine in Neonates With Hypoxic-Ischemic Encephalopathy Recruiting NCT03913221 Phase 1 Caffeine Citrate 5 mg/kg;Caffeine Citrate 10 mg/kg
48 The Evaluation of Safety and Tolerability of CL2020 in Neonatal Hypoxic Ischemic Encephalopathy Patients With Therapeutic Hypothermia in the Dose Escalation Clinical Trial Recruiting NCT04261335 Phase 1
49 Sildenafil Administration to Treat Neonatal Encephalopathy (SANE) and Repair Brain Injury Secondary to Birth Asphyxia: A Randomized, Double-blind, Placebo-controlled Pilot Phase Ib Study Active, not recruiting NCT02812433 Phase 1 Sildenafil;Ora-Blend
50 Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy Withdrawn NCT01904786 Phase 1 Melatonin;placebo

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

40
Brain, Cortex, Placenta, Globus Pallidus, Heart, Kidney, Lung

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 739)
# Title Authors PMID Year
1
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event]. 61
33775046 2021
2
Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension. 61
33416457 2021
3
Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease. 61
33739154 2021
4
How lung injury and therapeutic oxygen could alter white matter development. 61
33687103 2021
5
Recombinant Human Growth Hormone Activates Neuroprotective Growth Factors in Hypoxic Brain Injury in Neonatal Mice. 61
33545716 2021
6
Quantitative approach to early neonatal EEG visual analysis in hypoxic-ischemic encephalopathy severity: Bridging the gap between eyes and machine. 61
33402313 2021
7
Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic-Ischemic Encephalopathy in the Late Hypothermia Trial. 61
33189747 2021
8
Selective reduction in the expression of type-1 metabotropic glutamate receptors in the hippocampus of adult rats born by caesarean section. 61
33759234 2021
9
Early Environmental Upheaval and the Risk for Schizophrenia. 61
33544627 2021
10
Postnatal functional status of the brainstem auditory pathway in term infants after perinatal hypoxia-ischemia. 61
33530810 2021
11
Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets. 61
32294662 2021
12
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults. 61
32687731 2021
13
Long-Term Comorbid Neuropsychiatric Sequelae of Hypoxia at Birth. 61
33604219 2021
14
Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice. 61
33439967 2021
15
Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats. 61
33628369 2021
16
Novel Neuroprotective Agents to Treat Neonatal Hypoxic-Ischemic Encephalopathy: Inter-Alpha Inhibitor Proteins. 61
33276548 2020
17
Supplementing Merino ewes with melatonin during the last half of pregnancy improves tolerance of prolonged parturition and survival of second-born twin lambs. 61
33205209 2020
18
Maternal melatonin implants improve twin Merino lamb survival. 61
33091925 2020
19
Late onset oxygen requirement following neonatal therapeutic hypothermia. 61
32043655 2020
20
Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia. 61
32551816 2020
21
Electroacupuncture on the Scalp over the Motor Cortex Ameliorates Behavioral Deficits Following Neonatal Hypoxia-Ischemia in Rats via the Activation of Neural Stem Cells. 61
33066563 2020
22
Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells. 61
32691304 2020
23
New-onset epilepsy in pregnant women: clinical features and delivery outcomes. 61
32805607 2020
24
Nucleated Red Blood Cells: Could They Be Indicator Markers of Illness Severity for Neonatal Intensive Care Unit Patients? 61
33120882 2020
25
Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep. 61
32899855 2020
26
Changes in treatment needs of hypoparathyroidism during pregnancy and lactation: A case series. 61
32350890 2020
27
Prevalence of preschool children developmental disabilities in northeastern Taiwan - Screening with Taipei City Developmental Screening Checklist for Preschoolers, 2nd Version. 61
32089374 2020
28
Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies. 61
32703331 2020
29
Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama. 61
32584666 2020
30
Assessment of neonaticide in the setting of concealed and denied pregnancies. 61
32026385 2020
31
Erratum: Thromboelastometry Variables in Neonates with Perinatal Hypoxia. 61
32492714 2020
32
Thromboelastometry Variables in Neonates with Perinatal Hypoxia. 61
32438424 2020
33
Markers of perinatal hypoxia-ischaemia and neurological injury: assessing the impact of insult duration. 61
31872436 2020
34
Rosmarinic acid ameliorates hypoxia/ischemia induced cognitive deficits and promotes remyelination. 61
31719255 2020
35
The impact of maternal epilepsy on delivery and neonatal outcomes. 61
31786631 2020
36
Impact of perinatal hypoxia on the developing brain. 61
32199007 2020
37
Serum calcium derangements in neonates with moderate to severe hypoxic ischemic encephalopathy and the impact of therapeutic hypothermia: a cohort study. 61
30231649 2020
38
Prenatal or Perinatal Injury? Diagnosing the Cortically Blind Infant. 61
31704229 2020
39
Does Co-occurred Cerebral Palsy Change the Prognosis of West Syndrome? 61
31639881 2020
40
Clinical conundrum: status epilepticus culminating into acute dystonia myoclonus. 61
32111712 2020
41
Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia-Ischemia. 61
31785355 2020
42
Evaluation of Magnetic Resonance (MR) Findings in Patients with Refractory Epilepsy. 61
33312038 2020
43
Volume reduction of caudate nucleus is associated with movement coordination deficits in patients with hippocampal atrophy due to perinatal hypoxia-ischaemia. 61
33010533 2020
44
Effects of xenon gas on human airway epithelial cells during hyperoxia and hypothermia. 61
32444566 2020
45
Apoptotic Markers in the Midbrain of the Human Neonate After Perinatal Hypoxic/Ischemic Injury. 61
31803912 2020
46
NF155-overexpression promotes remyelination and functional restoration in a hypoxic-ischemic mixed neonatal rat forebrain cell culture system. 61
31917235 2020
47
Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses. 61
31257559 2019
48
Early-life N-arachidonoyl-dopamine exposure increases antioxidant capacity of the brain tissues and reduces functional deficits after neonatal hypoxia in rats. 61
31369794 2019
49
Glucose Levels during the First 24 Hours following Perinatal Hypoxia. 61
31683321 2019
50
Placental clearance/synthesis of neurobiomarkers GFAP and UCH-L1 in healthy term neonates and those with moderate-severe neonatal encephalopathy. 61
31132788 2019

Variations for Neonatal Hypoxic and Ischemic Brain Injury

ClinVar genetic disease variations for Neonatal Hypoxic and Ischemic Brain Injury:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 4 genes 46,XX,der(X)(p22.13,p22.13)dn.seq[GRCh37/hg19]der(X)(Xpter->Xp22.13(+)(18074005)::GCA...CAC{100}::p22.13(-)(18532312),p22.13(-)(17793009)::p22.13(+)(18248956)->Xqter)dn Complex Uncertain significance 561261 GRCh37: X:17793009-18532312
GRCh38:

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 TH SLC1A3 MBP ENO2
2 11.54 TH SLC1A3 BDNF
3 11.05 MBP BDNF
4 10.7 TH SLC1A3 BDNF

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.43 TH CKB BDNF
2 cell periphery GO:0071944 9.16 SLC1A3 MBP
3 axon GO:0030424 9.13 TH PVALB BDNF
4 neuronal cell body GO:0043025 9.1 TH SLC1A3 PVALB MBP ENO2 CKB

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.26 TH BDNF
2 substantia nigra development GO:0021762 9.16 MBP CKB
3 response to light stimulus GO:0009416 8.96 TH SLC1A3
4 sensory perception of sound GO:0007605 8.8 TH SLC1A3 MBP

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 TH SLC1A3

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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