HIE
MCID: NNT033
MIFTS: 42

Neonatal Hypoxic and Ischemic Brain Injury (HIE)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 58
Hypoxic-Ischemic Encephalopathy 58 71
Perinatal Asphyxia 58 71
Perinatal Hypoxia 58 71
Hypoxic and Ischemic Brain Injury in the Newborn 58
Encephalopathies Hypoxic-Ischemic 54
Hypoxic Ischemic Encephalopathy 6
Hie 58

Characteristics:

Orphanet epidemiological data:

58
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

UMLS via Orphanet 72 C0752304
Orphanet 58 ORPHA137577
UMLS 71 C0559477 C0559478 C0752304

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to brain injury and encephalomalacia. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Levodopa and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.8 MBP ENO2 BDNF
2 encephalomalacia 30.6 MBP BDNF
3 status epilepticus 30.4 PVALB ENO2 BDNF
4 hemiplegia 30.1 SLC1A3 ENO2
5 hydrocephalus 30.0 MBP ENO2 BDNF
6 traumatic brain injury 29.8 MBP ENO2 BDNF
7 cervical dystonia 29.5 TH BDNF
8 sleep disorder 29.5 TH BDNF
9 dystonia 29.0 TH PVALB BDNF
10 stroke, ischemic 28.8 TH MBP ENO2 BDNF
11 schizophrenia 27.7 TH SLC1A3 PVALB MBP BDNF
12 cerebral palsy, spastic quadriplegic, 1 11.4
13 seizure disorder 10.8
14 visual epilepsy 10.8
15 asphyxia neonatorum 10.8
16 encephalopathy 10.7
17 ocular motor apraxia 10.6
18 yemenite deaf-blind hypopigmentation syndrome 10.6
19 cardiac arrest 10.5
20 brain edema 10.5
21 hypoglycemia 10.5
22 pulmonary hypertension 10.5
23 chorioamnionitis 10.5
24 periventricular leukomalacia 10.5
25 placental abruption 10.5
26 west syndrome 10.4
27 anoxia 10.4
28 hypotonia 10.4
29 cerebral hypoxia 10.4
30 cerebral palsy 10.4
31 branchiootic syndrome 1 10.4
32 cortical blindness 10.4
33 cytokine deficiency 10.4
34 hydrops, lactic acidosis, and sideroblastic anemia 10.3
35 quadriplegia 10.3
36 hyperglycemia 10.3
37 47,xyy 10.3
38 neonatal stroke 10.3
39 48,xyyy 10.3
40 kidney disease 10.3
41 cardiac arrhythmia 10.3
42 insulin-like growth factor i 10.3
43 microcephaly 10.3
44 meconium aspiration syndrome 10.3
45 respiratory failure 10.3
46 toxic shock syndrome 10.3
47 epilepsy 10.3
48 inherited metabolic disorder 10.3
49 carotid artery occlusion 10.3
50 autonomic dysfunction 10.3

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.8 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.7 BDNF CKB ENO2 MBP PVALB SLC1A3
4 hearing/vestibular/ear MP:0005377 9.56 BDNF CKB MBP SLC1A3
5 no phenotypic analysis MP:0003012 9.26 BDNF PVALB SLC1A3 TH
6 vision/eye MP:0005391 9.02 BDNF MBP PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved Phase 4 59-92-7 6047
2
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
3
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
4
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
5 Tocotrienol Investigational Phase 4 6829-55-6
6 Sympathomimetics Phase 4
7 Dopamine Agents Phase 4
8 Dihydroxyphenylalanine Phase 4
9 Carbidopa, levodopa drug combination Phase 4
10 Tocopherols Phase 4
11 Tocotrienols Phase 4
12 Vitamins Phase 4
13 Pharmaceutical Solutions Phase 4
14
Midazolam Approved, Illicit Phase 3 59467-70-8 4192
15
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
16
tannic acid Approved Phase 3 1401-55-4
17
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
18
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
19
Allopurinol Approved Phase 3 315-30-0 2094
20
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
21
Aminophylline Approved Phase 3 317-34-0 9433
22
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
23
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
24
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
25
Racepinephrine Approved Phase 2, Phase 3 329-65-7 838
26
Choline Approved, Nutraceutical Phase 3 62-49-7 305
27
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
28 Nootropic Agents Phase 3
29 Analgesics Phase 3
30 Anesthetics, General Phase 3
31 Cytidine Diphosphate Choline Phase 3
32 Anesthetics, Intravenous Phase 3
33 Anti-Anxiety Agents Phase 3
34 Tranquilizing Agents Phase 3
35 Adjuvants, Anesthesia Phase 3
36 Psychotropic Drugs Phase 3
37 Anesthetics, Dissociative Phase 3
38 Calcium, Dietary Phase 2, Phase 3
39 Tocolytic Agents Phase 2, Phase 3
40 Anti-Arrhythmia Agents Phase 2, Phase 3
41 Hormones Phase 2, Phase 3
42 calcium channel blockers Phase 2, Phase 3
43 Acidophilus Phase 3
44 Bifidobacterium Phase 3
45 Protective Agents Phase 3
46 Antirheumatic Agents Phase 3
47 Phosphodiesterase Inhibitors Phase 3
48 Natriuretic Agents Phase 3
49 Free Radical Scavengers Phase 3
50 diuretics Phase 3

Interventional clinical trials:

(show top 50) (show all 169)
# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Single High Dose Vitamin E and Vitamin C in Hypoxic Ischemic Encephalopathy (Following Birth Asphyxia)in Newborns Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
3 Evaluation of Splanchnic Oximetry,Doppler Flow Velocimetry in the Superior Mesenteric Artery and Feeding Tolerance in VERY LOW BIRTH WEIGHT IUGR and NON-IUGR Infants Receiving Bolus Versus Continuous Enteral Nutrition Completed NCT01341236 Phase 4
4 Personalized Versus Standardized Parenteral Nutrition for Preterm Infants With a Birth Weight Greater Than 1250 Grams: a Multicenter Randomized Phase IV Clinical Trial Not yet recruiting NCT03693287 Phase 4 Standardized-parenteral nutrition (S-PN);Personalized-parenteral nutrition (P-PN)
5 A Pilot Study to Compare the Use of Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
6 A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
7 Phase III Study of Efficacy of High Dose Erythropoietin to Prevent Hypoxic-ischemic Encephalopathy Sequelae in Term Newborn Unknown status NCT01732146 Phase 3 erythropoietin Beta;Placebo
8 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Unknown status NCT03181646 Phase 3 citicoline
9 Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room. Unknown status NCT01517828 Phase 3 Sedation by ketamine;Sedation with Midazolam
10 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
11 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
12 Selective Head Cooling With Mild Systemic Hypothermia After Neonatal Hypoxic-Ischemic Encephalopathy: A Multi-Center Randomized Controlled Trial in China Completed NCT00890409 Phase 3
13 Randomized Controlled Trial of Hypothermia for Hypoxic-Ischemic Encephalopathy in Term Infants Completed NCT00005772 Phase 3
14 Comparison of Two Method of Therapeutic Hypothermia Enhanced by Magnesium Sulphate in Neonatal Encephalopathy Completed NCT02499393 Phase 2, Phase 3 Magnesium Sulfate
15 Erythropoietin in Perinatal Asphyxia: A Randomized Placebo Controlled Trial Completed NCT02002039 Phase 2, Phase 3 Erythropoietin
16 Magnesium Sulphate in Perinatal Asphyxia: A Randomized Placebo Controlled Trial. Completed NCT00553072 Phase 3 Magnesium sulphate;Normal saline
17 Role of Probiotics for Prevention of Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants: A Double Blind Randomized Controlled Trial Completed NCT02650869 Phase 3
18 Therapeutic Hypothermia After Pediatric Cardiac Arrest (Out of Hospital) Completed NCT00878644 Phase 3
19 Effect of ALlopurinol in Addition to Hypothermia for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a Blinded Randomized Placebo-controlled Parallel Group Multicenter Trial for Superiority (Phase III) Recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
20 A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age. Recruiting NCT01793129 Phase 2, Phase 3
21 Preventing Adverse Outcomes of Neonatal Hypoxic Ischaemic Encephalopathy With Erythropoietin: A Phase III Randomised Placebo Controlled Multicentre Clinical Trial Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
22 Improved Diagnosis and Prognostication of Hypoxic Ischemic Injury in Neonates and Infants Using Contrast-Enhanced Ultrasound Recruiting NCT03549520 Phase 3 Sulfur hexafluoride lipid-type A microspheres
23 The Effect of Aminophylline on Preventing Acute Kidney Injury in Neonates and Infants With Congenital Heart Disease Undergoing Open Heart Surgery Recruiting NCT03897335 Phase 3 Aminophylline;Placebos
24 High-dose Erythropoietin for Asphyxia and Encephalopathy Active, not recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
25 Prospective, Randomized, Double-blind, Cohort Study of Hydrocortisone vs Placebo in Systemic Low Blood Pressure During Hypothermia Treatment in Asphyxiated Newborns Active, not recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
26 Effect of Erythropoietin and Hypothermia on Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
27 Short-term Outcomes of Umbilical Cord Milking in Term and Late Preterm Neonates Who Are Depressed at Birth Not yet recruiting NCT03657394 Phase 3
28 Effects of Probiotic Mixture Supplementation and Evaluation of Intestinal Mucosal Tolerance and Gut Microbiome in Newborns With Perinatal Asphyxia Receiving Hypothermic Treatment: a Randomized, Multicentric, Blinded, Controlled Trial Not yet recruiting NCT04145713 Phase 3
29 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
30 A Randomized, Double-blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy of Phenobarbital Sodium Injection for the Treatment of Neonatal Seizures Withdrawn NCT03602118 Phase 3 Phenobarbital Sodium Injection
31 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth: A Randomised Pilot Study Unknown status NCT01545271 Phase 1, Phase 2 xenon gas
32 Phase II Randomized Control Trial of Whole Body Cooling in Neonatal Encephalopathy Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
33 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes Study Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
34 Phase 2 Nerve Growth Factor (Cerebrolysin®) for Treatment of Neonatal Hypoxic Ischemic Encephalopathy Completed NCT01059461 Phase 2 Cerebrolysin®
35 Safety and Efficacy of Oral Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia: a Pilot Study of the Neonatal Neuroprotection of Asphyxiated Tuscan Infants (NeoNATI) Network Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
36 Effect of Erythropoietin on Neonatal Hypoxic Ischemic Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
37 Effect of Systemic Hypothermia on Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
38 Melatonin for Neuroprotection Following Perinatal Asphyxia Completed NCT02071160 Phase 1, Phase 2 Melatonin
39 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
40 NEMO1: An Open Label Exploratory Dose Finding and Pharmacokinetic Clinical Trial of Bumetanide for the Treatment of Neonatal Seizure Using Medication Off-patent Completed NCT01434225 Phase 1, Phase 2 Bumetanide
41 A Phase II Multi-site Study of Autologous Cord Blood Cells for Hypoxic (HIE) Completed NCT02612155 Phase 2
42 Human Recombinant Erythropoietin (HrEPO) in Asphyxia Neonatorum: A Pilot Trial Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
43 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
44 Delayed Cord Clamping in VLBW Infants Pilot Study Completed NCT01222364 Phase 1, Phase 2
45 Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
46 Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis Completed NCT03295162 Phase 1, Phase 2 Melatonin 10 mg
47 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
48 Topiramate as an Adjuvant to Therapeutic Hypothermia for Infants With Hypoxic Ischemic Encephalopathy Recruiting NCT01765218 Phase 1, Phase 2 Topiramate;Placebo
49 Levetiracetam Efficacy and Safety as First-line Treatment of Neonatal Seizures Occuring in Hypoxic-ischemic Encephalopathy Context Recruiting NCT02229123 Phase 2 Intravenous Levetiracetam
50 A Multi-Centre Safety and Efficacy Study of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonates Encephalopathy in China Recruiting NCT02551003 Phase 1, Phase 2 Autologous cord blood

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

40
Brain, Heart, Kidney, Testes, Placenta, Cortex, Globus Pallidus

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 702)
# Title Authors PMID Year
1
Rosmarinic acid ameliorates hypoxia/ischemia induced cognitive deficits and promotes remyelination. 61
31719255 2020
2
Serum calcium derangements in neonates with moderate to severe hypoxic ischemic encephalopathy and the impact of therapeutic hypothermia: a cohort study. 61
30231649 2020
3
Does Co-occurred Cerebral Palsy Change the Prognosis of West Syndrome? 61
31639881 2020
4
Assessment of neonaticide in the setting of concealed and denied pregnancies. 61
32026385 2020
5
NF155-overexpression promotes remyelination and functional restoration in a hypoxic-ischemic mixed neonatal rat forebrain cell culture system. 61
31917235 2020
6
Apoptotic Markers in the Midbrain of the Human Neonate After Perinatal Hypoxic/Ischemic Injury. 61
31803912 2020
7
Thioredoxin 1 Plays a Protective Role in Retinas Exposed to Perinatal Hypoxia-Ischemia. 61
31785355 2020
8
Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses. 61
31257559 2019
9
Markers of perinatal hypoxia-ischaemia and neurological injury: assessing the impact of insult duration. 61
31872436 2019
10
Glucose Levels during the First 24 Hours following Perinatal Hypoxia. 61
31683321 2019
11
Prenatal or Perinatal Injury? Diagnosing the Cortically Blind Infant. 61
31704229 2019
12
The impact of maternal epilepsy on delivery and neonatal outcomes. 61
31786631 2019
13
Early-life N-arachidonoyl-dopamine exposure increases antioxidant capacity of the brain tissues and reduces functional deficits after neonatal hypoxia in rats. 61
31369794 2019
14
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS. 61
30818057 2019
15
Distribution analysis of infantile hemangioma or capillary malformation on the head and face in Japanese patients. 61
31418467 2019
16
Placental clearance/synthesis of neurobiomarkers GFAP and UCH-L1 in healthy term neonates and those with moderate-severe neonatal encephalopathy. 61
31132788 2019
17
Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats. 61
31540369 2019
18
Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing. 61
30644551 2019
19
Erythropoietin induces synaptogenesis and neurite repair after hypoxia ischemia-mediated brain injury in neonatal rats. 61
31261238 2019
20
Arundic acid administration protects astrocytes, recovers histological damage and memory deficits induced by neonatal hypoxia ischemia in rats. 61
31202867 2019
21
The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions. 61
31063821 2019
22
Laboratory criteria of perinatal damage of central nervous system at premature newborns 61
32012501 2019
23
Routine assessment of cerebroplacental ratio at 35-37 weeks' gestation in the prediction of adverse perinatal outcome. 61
30878322 2019
24
Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia. 61
31006090 2019
25
Altered prepulse inhibition of the acoustic startle response in BDNF-deficient mice in a model of early postnatal hypoxia: implications for schizophrenia. 61
29453493 2019
26
Microglia and Neonatal Brain Injury. 61
29352997 2019
27
Long-Term Effects of Hypoxia-Reoxygenation on Thioredoxins in Rat Central Nervous System. 61
31823698 2019
28
The association between perinatal hypoxia exposure and externalizing symptoms and children's decision making in conditions of uncertainty is moderated by DRD2 genotype. 61
30264459 2019
29
Assessment of selected parameters of placental microstructure in patients with intrahepatic cholestasis of pregnancy. 61
31482548 2019
30
The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health. 61
30315933 2019
31
Genome-Wide Alteration of 5-Hydroxymethylcytosine in Hypoxic-Ischemic Neonatal Rat Model of Cerebral Palsy. 61
31551709 2019
32
Glutamate Transport and Preterm Brain Injury. 61
31068830 2019
33
Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy. 61
30201311 2018
34
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas. 61
29369354 2018
35
Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy. 61
30149778 2018
36
Pregnancy as a valuable period for preventing hypoxia-ischemia brain damage. 61
29920306 2018
37
Magnesium sulphate induces preconditioning in preterm rodent models of cerebral hypoxia-ischemia. 61
29355709 2018
38
Neurological impairments in hypoxic neonates and lactate levels. 61
29912656 2018
39
Activation of hypoxia-inducible factor-1α in rat brain after perinatal anoxia: role of body temperature. 61
28974122 2018
40
Gender-dependent changes in physical development, BDNF content and GSH redox system in a model of acute neonatal hypoxia in rats. 61
29753727 2018
41
Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia. 61
29874549 2018
42
Perinatal Hypoxic-Ischemic Encephalopathy and Neuroprotective Peptide Therapies: A Case for Cationic Arginine-Rich Peptides (CARPs). 61
30087289 2018
43
Xenon Combined With Hypothermia in Perinatal Hypoxic-Ischemic Encephalopathy: A Noble Gas, a Noble Mission. 61
29887039 2018
44
Subcutaneous Fat Necrosis and Hypercalcemia After Therapeutic Hypothermia in Patients With Hypoxic-ischemic Encephalopathy: A Case Series. 61
30280069 2018
45
Perinatal brain injury: mechanisms and therapeutic approaches. 61
29772556 2018
46
Subcutaneous fat necrosis of the newborn: clinical and histopathological correlation. 61
29924224 2018
47
The Six-Hour Window: How the Community Hospital Nursery Can Optimize Outcomes of the Infant with Suspected Hypoxic-Ischemic Encephalopathy. 61
29789056 2018
48
Blood biomarkers for evaluation of perinatal encephalopathy: state of the art. 61
29346139 2018
49
Perinatal hypoxia as a risk factor for psychopathology later in life: the role of dopamine and neurotrophins. 61
29858855 2018
50
Cutaneous complication of perinatal hypoxia. 61
29634887 2018

Variations for Neonatal Hypoxic and Ischemic Brain Injury

ClinVar genetic disease variations for Neonatal Hypoxic and Ischemic Brain Injury:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BEND2 , CDKL5 , RAI2 , SCML2 46,XX,der(X)(p22.13,p22.13)dn.seq[GRCh37/hg19]der(X)(Xpter->Xp22.13(+)(18074005)::GCA...CAC{100}::p22.13(-)(18532312),p22.13(-)(17793009)::p22.13(+)(18248956)->Xqter)dncomplex Uncertain significance 561261 X:17793009-18532312

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 TH SLC1A3 MBP ENO2
2 11.54 TH SLC1A3 BDNF
3 11.05 MBP BDNF
4 10.7 TH SLC1A3 BDNF

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.43 TH CKB BDNF
2 cell periphery GO:0071944 9.16 SLC1A3 MBP
3 axon GO:0030424 9.13 TH PVALB BDNF
4 neuronal cell body GO:0043025 9.1 TH SLC1A3 PVALB MBP ENO2 CKB

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.26 TH BDNF
2 substantia nigra development GO:0021762 9.16 MBP CKB
3 response to light stimulus GO:0009416 8.96 TH SLC1A3
4 sensory perception of sound GO:0007605 8.8 TH SLC1A3 MBP

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 TH SLC1A3

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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