MCID: NNT012
MIFTS: 53

Neonatal Jaundice

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to glucosephosphate dehydrogenase deficiency and gilbert syndrome, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Th17 cell differentiation and Tuberculosis. The drugs Oxytocin and Zinc have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and skin, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 73 Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 587)
# Related Disease Score Top Affiliating Genes
1 glucosephosphate dehydrogenase deficiency 32.0 UGT1A1 SLCO1B1 PKLR G6PD
2 gilbert syndrome 30.4 UGT1A1 SLCO1B1 HMOX2 HMOX1 G6PD
3 enterocolitis 30.3 TNF IL6 IL10
4 chickenpox 30.1 TNF IL6 IL10
5 hepatitis a 30.1 TNF IL1B IL10
6 conjunctivitis 30.1 TNF IL6 IL10
7 cholestasis 30.1 UTP4 SLCO1B1 NR1I3 JAG1 HSD3B7
8 hereditary spherocytosis 30.1 UGT1A1 SPTA1 PKLR G6PD
9 acute cystitis 30.1 TNF IL6 IL1B IL10
10 crigler-najjar syndrome, type i 30.1 UGT1A1 SLCO1B1 NR1I3
11 pain agnosia 30.0 TNF OXT IL6 IL1B
12 exanthem 30.0 TNF IL6 IL1B IL10
13 toxoplasmosis 29.9 TNF IL6 IL1B IL10
14 cerebral palsy 29.9 TNF IL6 IL1B IL10
15 perinatal necrotizing enterocolitis 29.9 TNF IL6 IL1B IL10
16 otitis media 29.8 TNF IL6 IL1B IL10
17 cholangitis 29.8 TNF IL6 IL10
18 pertussis 29.8 TNF IL6 IL1B IL10
19 disease by infectious agent 29.7 TNF IL6 IL1B IL10
20 leprosy 3 29.7 TNF IL6 IL1B IL10
21 liver disease 29.7 UGT1A1 TNF IL6 IL1B HSD3B7
22 respiratory failure 29.6 TNF IL6 IL1B IL10 G6PD
23 bacterial sepsis 29.6 TNF IL6 IL1B IL10
24 dermatitis, atopic 29.6 TNF IL6 IL1B IL10
25 bacterial infectious disease 29.6 TNF IL6 IL1B IL10
26 salmonellosis 29.6 TNF IL6 IL1B IL10
27 beta-thalassemia 29.6 UGT1A1 SPTA1 IL6 GSTM1 G6PD
28 mumps 29.6 TNF IL6 IL1B IL10
29 rubella 29.6 TNF IL6 IL1B IL10
30 toxic shock syndrome 29.6 TNF IL6 IL1B IL10
31 covid-19 29.6 TNF IL6 IL1B
32 leptin deficiency or dysfunction 29.6 TNF OXT IL6 IL10
33 viral hepatitis 29.5 TNF IL6 IL1B IL10 G6PD
34 cystic fibrosis 29.4 TNF IL6 IL1B IL10 HMOX1 GSTM1
35 pre-eclampsia 29.2 TNF OXT IL6 IL1B IL10 HMOX1
36 liver cirrhosis 29.2 TNF IL6 IL1B IL10 ADAMTS13
37 disseminated intravascular coagulation 29.2 TNF IL6 IL10 ADAMTS13
38 hemorrhagic disease 29.0 TNF IL6 IL1B IL10 ADAMTS13
39 hemolytic anemia 29.0 UGT1A1 TNF SPTA1 PKLR IL10 HMOX1
40 bilirubin metabolic disorder 28.8 UGT1A1 TNF SLCO1B1 OXT NR1I3 IL6
41 malaria 28.1 TNF SPTA1 PKLR IL6 IL1B IL10
42 deficiency anemia 28.0 TNF SPTA1 PKLR OXT IL6 HMOX1
43 kernicterus 11.3
44 sialuria 11.1
45 north american indian childhood cirrhosis 11.1
46 stomatin-deficient cryohydrocytosis with neurologic defects 11.0
47 bamforth syndrome 11.0
48 anemia, nonspherocytic hemolytic, due to g6pd deficiency 11.0
49 pyruvate kinase deficiency of red cells 11.0
50 alpha-1-antitrypsin deficiency 11.0

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


icterus; newborn physiological jaundice

MGI Mouse Phenotypes related to Neonatal Jaundice:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 BTD G6PD HMOX1 HMOX2 HSD3B7 IL10
2 homeostasis/metabolism MP:0005376 10.13 ADAMTS13 BTD G6PD HMOX1 HMOX2 HSD3B7
3 hematopoietic system MP:0005397 10.1 ADAMTS13 G6PD HMOX1 HMOX2 IL10 IL1B
4 digestive/alimentary MP:0005381 10.01 HMOX2 HSD3B7 IL10 IL6 JAG1 OXT
5 integument MP:0010771 9.9 BTD HMOX2 HSD3B7 IL10 IL1B IL6
6 liver/biliary system MP:0005370 9.56 HMOX1 HSD3B7 IL10 IL6 JAG1 NR1I3
7 mortality/aging MP:0010768 9.5 ADAMTS13 G6PD HMOX1 HMOX2 HSD3B7 IL10

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
2
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Tin mesoporphyrin Phase 2
6 Pharmaceutical Solutions Phase 2
7
Glycerol Approved, Investigational 56-81-5 753
8
Fenofibrate Approved 49562-28-9 3339
9
tannic acid Approved 1401-55-4
10
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
11
Iron Approved 7439-89-6 23925 29936
12
Ceftriaxone Approved 73384-59-5 5479530 5361919
13 Antibodies, Anti-Idiotypic
14 Bifidobacterium
15 Trace Elements
16 Micronutrients
17 Hypolipidemic Agents
18 Antimetabolites
19 Lipid Regulating Agents
20 Acidophilus
21 Anti-Bacterial Agents
22 Anti-Infective Agents
23 Antioxidants
24 Protective Agents

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels .A Prospective Randomized Controlled Trial. Unknown status NCT02602301 Phase 4 Oxytocin
2 A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
3 Efficacy of Reverse Phototherapy With Super Light-emitting Diode(Super-led) in Term and Late Preterm Infants:Randomized and Controlled Clinical Trial Unknown status NCT01340339 Phase 4
4 Utilisation du Dispositif BBloo® Pour le Traitement de l'ictère néonatal : Satisfaction Des Parents et Des Personnels Soignants Unknown status NCT02156050 Phase 4
5 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Unknown status NCT03266913 Phase 3 Probiotic
6 A Randomized Trial of Aggressive or Conservative Phototherapy for Extremely Low Birth Weight Infants Completed NCT00114543 Phase 3
7 Routine Use of Transcutaneous Bilirubinometry Reduces the Need for Blood Sampling in Neonates With Jaundice Completed NCT00653874 Phase 3
8 Effect of Oral Zinc Given Daily Between Days 2 and 7 of Life to Term or Near Term Neonates With Serum Bilirubin Levels of More Than 6 mg/dL at 24 ± 6 Hours of Life on Hyperbilirubinemia and Phototherapy Completed NCT00692224 Phase 1, Phase 2 zinc gluconate;placebo
9 A Phase 2b Multicenter, Single Dose, Randomized, Double Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates Completed NCT01887327 Phase 2 Stannsoporfin;Placebo
10 Improvement in Gross Motor Function and Muscle Tone in Children With Cerebral Palsy Related to Neonatal Icterus: An Open-label, Uncontrolled Clinical Trial Completed NCT03123562 Phase 2
11 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
12 A Phase 2b, Multicenter, Single-dose, Blinded, Randomized, Placebo-controlled, Dose-escalation, Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia Terminated NCT00850993 Phase 2 Stannsoporfin
13 A Prospective Multicenter Non-inferiority Randomized Controlled Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice Unknown status NCT03055481
14 Unbound Bilirubin Levels in Healthy Term and Late Preterm Infants Unknown status NCT03237715
15 Comparison of the Efficacy of Phototherapy With Wavelength 478 vs. 459 nm for Treatment of Neonatal Jaundice Using Blue LED's. Unknown status NCT03183986
16 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis in ABO-compatible and Incompatible Healthy Term Newborn Infants. Unknown status NCT00917007
17 Point-of-Care System for Determination of Bilirubin Capacity in Neonates Unknown status NCT02612207
18 Hour-specific Transcutaneous Bilirubin in Healthy Term and Near-term Newborns of China Unknown status NCT03805165
19 The Efficacy of Oral Probiotics on Neonatal Hyperbilirubinemia Unknown status NCT03876678
20 Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment in Late Pre-term and Term Infants; a Facility-based Randomized-controlled Trial in Nepal Unknown status NCT02222805
21 Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform. Unknown status NCT00154960
22 Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy on Oxidative Stress Among Neonates With Unconjugated Hyperbilirubinemia Unknown status NCT03074292
23 The Use of Glycerin Suppositories to Reduce Hyperbilirubinemia in Premature Infants Requiring Phototherapy Completed NCT01746511 glycerin suppository
24 Investigation of the Effect of Massage on Bilirubin Level in Preterm Infants Completed NCT04099602
25 Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes Completed NCT02154165
26 Evaluation of a Smartphone Based Optical Diagnostic Tool for Neonatal Jaundice Completed NCT03007563
27 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810
28 Effectiveness, Safety and Perceptions With the Use of One LED Blanket Device in the Ambulatory Treatment of Neonatal Jaundice Completed NCT03569254
29 Understanding Neonatal Jaundice in Rwanda Completed NCT03184948
30 Comparison of Transcutaneous or Laboratory Measurement of Bilirubin in the Newborn Completed NCT01169740
31 Aluminium Foil as an Adjuvant to Phototherapy for Pathological Unconjugated Hyperbilirubinaemia in Full Term Infants: Randomised Control Trial Completed NCT04433923
32 Fenofibrate as an Adjuvant to Phototherapy in Pathological Unconjugated Hyperbilirubinemia in Full Term Infants: A Randomized Control Trial. Completed NCT04418180 Fenofibrate;Placebo
33 Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns Completed NCT02613676
34 Implementation of a Transcutaneous Bilirubinometer in Jaundiced Newborns: a Randomised Controlled Trial Completed NCT01622699
35 Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho Completed NCT03306004
36 Implementation of a Clinical Decision Rule for Treatment of Neonatal Jaundice in the Emergency Department Completed NCT02446951
37 Effectiveness, Safety and Perceptions With the Use of One Phototherapy LED Device: a Sleeping Bag for Hospital Treatment of Neonatal Jaundice Completed NCT03570775
38 Transcutaneous Bilirubinometers in the Community and the Reduction of Morbidity Associated to Jaundice: A Clustered Randomized Controlled Trial. Completed NCT00735319
39 The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion: A Randomized-blinded Controlled Trial Completed NCT02625688
40 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727
41 Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based Study Completed NCT01599611
42 Home Phototherapy for Term Newborns With Icterus, a Clinical Randomized Blinded Trial Completed NCT03536078
43 Accuracy of Transcutaneous Bilirubin Determinations in Neonates: The Effect of Gestational Age, Time and Site of Measurement Completed NCT01422655
44 Effects of Probiotics on Neonatal Hyperbilirubinemia Completed NCT02807246
45 Bilicurves: Using Information Technology to Integrate Clinical Practice Guidelines Into the Management of Neonatal Hyperbilirubinemia Completed NCT00801619
46 Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia Completed NCT04373980
47 Neonatal, Clinical and Neurodevelopmental Outcome of Neonates Hospitalized for Neonatal Hyperbilirubinemia Reaching Exchange Transfusion Threshold in a Remote Setting Along the Thai-Myanmar Border Completed NCT02927093
48 Baseline Assessment of Neonatal Hyperbilirubinaemia in a Cohort of New-borns in Kinshasa, Democratic Republic of Congo Completed NCT03880591
49 Dose-response Relationship of Phototherapy for Hyperbilirubinaemia Using Diodes: is There a "Saturation Point"? Completed NCT01470820
50 An Evidence-based Strategy for Assessing the Risk of Significant Neonatal Hyperbilirubinemia Completed NCT01109277

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

40
Bone, Liver, Skin, Kidney, Eye, Brain, Heart

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 2343)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt. 61 54
20426517 2010
2
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. 54 61
20007901 2009
3
[Relationship between glucose-6-phosphate dehydrogenase gene mutations and neonatal jaundice in Naning, Guangxi]. 61 54
20113600 2009
4
Xenobiotic-sensing nuclear receptors CAR and PXR as drug targets in cholestatic liver disease. 54 61
19925451 2009
5
A prolonged neonatal jaundice associated with a rare G6PD mutation. 61 54
19422023 2009
6
[Glucose-6-phosphate dehydrogenase deficiency: clinical presentation and eliciting factors]. 54 61
18547022 2008
7
Efficacy of clofibrate on severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency (a randomized clinical trial). 61 54
18564698 2008
8
Glucose-6-phosphate dehydrogenase deficiency. 54 61
18177777 2008
9
Cord blood bilirubin level in relation to bilirubin UDP-glucuronosyltransferase gene missense allele in Chinese neonates. 61 54
17888052 2007
10
A review of Orang Asli newborns admitted to a neonatal unit in a Malaysian general hospital. 61 54
17909678 2007
11
Massive acute haemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient preterm triplets. 61 54
17489836 2007
12
The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice. 54 61
17166930 2007
13
Glucose-6-phosphate dehydrogenase--from oxidative stress to cellular functions and degenerative diseases. 54 61
17623517 2007
14
Prevalence of G6PD deficiency in newborns in the south of Brazil. 61 54
16792831 2006
15
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]. 61 54
16255851 2005
16
Poor correlation between hemolysis and jaundice in glucose 6-phosphate dehydrogenase-deficient babies. 61 54
15910447 2005
17
Neonatal screening of glucose-6-phosphate dehydrogenase deficiency in Yanbu, Saudi Arabia. 61 54
16417692 2005
18
Screening for G71R mutation of the UGT1A1 gene in the Javanese-Indonesian and Malay-Malaysian populations. 61 54
15491385 2004
19
An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates. 61 54
14972648 2004
20
Glucose-6-phosphate dehydrogenase deficiency in neonates. 61 54
14703221 2003
21
Neonatology in Singapore: the way we were, the way forward. 61 54
12854374 2003
22
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). 61 54
12644704 2003
23
Glucose-6-phosphate dehydrogenase (G-6-PD) levels in jaundiced neonates in Calabar. 54 61
12956017 2003
24
Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. 61 54
12552319 2003
25
[Interest in the study of genetic variants of the promoter region of the UGT1A1 gene in neonatal jaundice]. 54 61
11827650 2002
26
Neonatal jaundice--traditional Chinese medicine approach. 54 61
11803427 2001
27
Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency. 61 54
11803413 2001
28
Onset of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates. 61 54
11581450 2001
29
A novel inhibitor of beta-glucuronidase: L-aspartic acid. 61 54
11568288 2001
30
Low glucose-6-phosphate dehydrogenase enzyme activity level at the time of hemolysis in a male neonate with the African type of deficiency. 61 54
11783956 2001
31
A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns. 54 61
11433050 2001
32
The value of methemoglobin reduction test as a screening test for neonatal glucose 6-phosphate dehydrogenase deficiency. 61 54
11529386 2001
33
[Glucose-6-phosphate dehydrogenase et neonatal jaundice]. 61 54
11317924 2001
34
Molecular characterization of a German variant of glucose-6-phosphate dehydrogenase deficiency (G6PD Aachen). 61 54
10772881 2000
35
Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Chinese. 61 54
10502785 1999
36
A variant TATA box in the bilirubin UDP-glucuronosyltransferase 1 gene promoter does not contribute to neonatal jaundice in the Japanese population. 54 61
10507878 1999
37
Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome. 61 54
10220506 1999
38
Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn. 54 61
10190918 1999
39
Glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Al-Hofuf area. 61 54
17337961 1999
40
Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn. 61 54
11400792 1999
41
Gilbert syndrome accelerates development of neonatal jaundice. 54 61
9580766 1998
42
Two new mutations of the glucose-6-phosphate dehydrogenase (G6PD) gene associated with haemolytic anaemia: clinical, biochemical and molecular relationships. 61 54
9332310 1997
43
[The preliminary study on prevention and treatment of neonatal jaundice]. 61 54
9596945 1997
44
Can severe neonatal jaundice be prevented by neonatal screening for glucose-6-phosphate dehydrogenase deficiency?--a review of evidence. 54 61
8942026 1996
45
G6PD NanKang (517 T-->C; 173 Phe-->Leu): a new Chinese G6PD variant associated with neonatal jaundice. 61 54
8807322 1996
46
G6PD: population genetics and clinical manifestations. 61 54
8861278 1996
47
The negative heritability of neonatal jaundice. 54 61
8835092 1996
48
Neonatal jaundice and molecular mutations in glucose-6-phosphate dehydrogenase deficient newborn infants. 61 54
8571933 1996
49
Enzyme deficiencies in neonates with jaundice. 61 54
8710395 1995
50
Role of hemolysis in neonatal jaundice associated with glucose-6 phosphate dehydrogenase deficiency. 61 54
7472840 1995

Variations for Neonatal Jaundice

ClinVar genetic disease variations for Neonatal Jaundice:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ST3GAL3 NM_006279.5(ST3GAL3):c.1046C>T (p.Thr349Met) SNV Uncertain significance 805790 rs1201878175 GRCh37: 1:44395811-44395811
GRCh38: 1:43930139-43930139

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

Pathways related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 TNF JAG1 IL6 IL1B IL10
2 12.18 TNF IL6 IL1B IL10
3
Show member pathways
12.17 TNF IL6 IL1B HMOX1
4
Show member pathways
12.16 TNF IL6 IL1B IL10
5 12.12 TNF IL6 IL1B IL10
6 12.05 UGT1A1 HMOX1 GSTM1 G6PD
7 12.02 TNF IL1B HMOX1 GSTM1
8 12 TNF IL6 IL1B IL10
9 11.87 TNF JAG1 IL6 IL1B
10 11.82 TNF IL6 IL1B IL10
11 11.8 TNF IL6 IL1B
12 11.73 TNF IL1B IL10
13 11.71 TNF IL6 IL1B IL10 HMOX1
14
Show member pathways
11.66 TNF IL6 IL1B IL10
15 11.64 TNF IL6 IL10
16 11.64 TNF IL6 IL1B IL10
17
Show member pathways
11.61 TNF IL6 IL1B
18 11.6 TNF IL6 IL1B IL10
19 11.56 TNF IL6 IL1B
20 11.5 TNF IL6 IL1B HMOX1
21 11.47 UGT1A1 TNF IL1B
22 11.43 TNF IL6 IL1B
23 11.37 TNF IL6 IL1B IL10
24 11.31 TNF IL6 IL1B IL10
25
Show member pathways
11.27 UGT1A1 SLCO1B1 NR1I3
26 11.23 TNF IL6 IL1B
27 11.2 TNF IL6 IL1B
28 11.02 TNF IL6 IL1B IL10
29 10.95 TNF IL6 HMOX1
30 10.73 IL6 IL1B
31 10.72 TNF IL6 IL1B IL10
32 10.57 TNF IL6 IL1B IL10 HMOX1

GO Terms for Neonatal Jaundice

Cellular components related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF OXT IL6 IL1B IL10 HMOX1

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.89 TNF IL6 IL1B IL10 HMOX1
2 positive regulation of interleukin-6 production GO:0032755 9.83 TNF IL6 IL1B
3 response to organic substance GO:0010033 9.82 UGT1A1 TNF IL10
4 regulation of insulin secretion GO:0050796 9.81 TNF IL6 IL1B
5 hemopoiesis GO:0030097 9.8 SPTA1 JAG1 IL10
6 positive regulation of T cell proliferation GO:0042102 9.79 SPTA1 IL6 IL1B
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 TNF IL6 HMOX1
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 TNF IL6 IL1B IL10
9 positive regulation of interleukin-8 production GO:0032757 9.77 TNF IL6 IL1B
10 negative regulation of fat cell differentiation GO:0045599 9.76 TNF JAG1 IL6
11 response to activity GO:0014823 9.75 OXT IL6 IL10
12 positive regulation of chemokine production GO:0032722 9.72 TNF IL6 HMOX1
13 cellular response to lipopolysaccharide GO:0071222 9.72 TNF IL6 IL1B IL10 ADAMTS13
14 liver regeneration GO:0097421 9.7 IL6 IL10 HMOX1
15 positive regulation of JAK-STAT cascade GO:0046427 9.69 TNF IL6 IL10
16 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
17 positive regulation of prostaglandin secretion GO:0032308 9.63 OXT IL1B
18 negative regulation of lipid storage GO:0010888 9.63 TNF IL6
19 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
20 negative regulation of neurogenesis GO:0050768 9.61 TNF IL6 IL1B
21 negative regulation of cytokine production involved in immune response GO:0002719 9.59 TNF IL10
22 positive regulation of glial cell proliferation GO:0060252 9.58 TNF IL6 IL1B
23 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
24 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 TNF IL1B IL10
27 heme oxidation GO:0006788 9.46 HMOX2 HMOX1
28 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
29 heme catabolic process GO:0042167 9.33 UGT1A1 HMOX2 HMOX1
30 vascular endothelial growth factor production GO:0010573 9.13 TNF IL6 IL1B
31 response to glucocorticoid GO:0051384 9.02 UGT1A1 TNF OXT IL6 IL10

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B IL10
2 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX2 HMOX1

Sources for Neonatal Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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