MCID: NNT012
MIFTS: 52

Neonatal Jaundice

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to kernicterus and pyruvate kinase deficiency of red cells, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glucose / Energy Metabolism and Porphyrin and chlorophyll metabolism. The drugs Oxytocin and Metformin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast.

Wikipedia : 77 Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 kernicterus 32.8 G6PD UGT1A1
2 pyruvate kinase deficiency of red cells 32.4 G6PD PKLR
3 glucosephosphate dehydrogenase deficiency 30.2 G6PD SLCO1B1 UGT1A1
4 gilbert syndrome 29.9 G6PD SLCO1B1 UGT1A1
5 cholestasis 29.6 NR1I3 SLCO1B1 UTP4
6 hereditary spherocytosis 29.4 G6PD PKLR SPTA1 UGT1A1
7 bilirubin metabolic disorder 28.9 G6PD HMOX1 NR1I3 SLCO1B1 UGT1A1
8 stomatin-deficient cryohydrocytosis with neurologic defects 11.1
9 bamforth syndrome 11.1
10 bile acid synthesis defect, congenital, 4 11.0
11 niemann-pick disease, type c1 11.0
12 sialuria 11.0
13 anemia, nonspherocytic hemolytic, due to g6pd deficiency 11.0
14 immunodeficiency 47 11.0
15 north american indian childhood cirrhosis 11.0
16 bile acid synthesis defect, congenital, 1 11.0
17 alpha-1-antitrypsin deficiency 11.0
18 peroxisome biogenesis disorder 10b 11.0
19 hyperbilirubinemia, transient familial neonatal 10.6
20 congenital nonspherocytic hemolytic anemia 10.2 G6PD PKLR
21 irinotecan toxicity 10.2 SLCO1B1 UGT1A1
22 pigmentation disease 10.2 SLCO1B1 UGT1A1
23 plasmodium vivax malaria 10.1 G6PD IL6
24 arteriovenous fistula 10.1 HMOX1 IL6
25 biliary atresia 10.1
26 retinal artery occlusion 10.1 HMOX1 IL6
27 autism 10.0
28 cystic fibrosis 10.0
29 toxoplasmosis 10.0
30 encephalopathy 10.0
31 congenital hemolytic anemia 9.9 G6PD PKLR SPTA1
32 hemolytic anemia 9.9 G6PD PKLR SPTA1
33 senile cataract 9.9 G6PD GSTM1
34 liver disease 9.9
35 acute cystitis 9.9
36 athetosis 9.9
37 cytomegalic inclusion disease 9.9
38 ischemic optic neuropathy 9.8 G6PD GSTM1
39 cleidocranial dysplasia 9.8
40 ovalocytosis, southeast asian 9.8
41 alpha-thalassemia 9.8
42 glutathione peroxidase deficiency 9.8
43 leukemia 9.8
44 thrombosis 9.8
45 epilepsy 9.8
46 dermatitis 9.8
47 hyperthyroxinemia 9.8
48 childhood leukemia 9.8
49 hypopituitarism 9.8
50 hypoglycemia 9.8

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


icterus, newborn physiological jaundice

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-56-6 439302 53477758
2
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
3
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-66-6 32051
4
Scopolamine Approved, Investigational Phase 4 6533-68-2, 51-34-3 5184
5
leucovorin Approved Phase 4 58-05-9 6006 143
6
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
7
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
8
Insulin Aspart Approved Phase 4 116094-23-6 16132418
9
Insulin Lispro Approved Phase 4 133107-64-9
10
Glyburide Approved Phase 4,Phase 3,Not Applicable 10238-21-8 3488
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13
Bilirubin Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 635-65-4, 69853-43-6 5280352 21252250
14 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
15 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
16 Oxytocics Phase 4,Phase 3
17 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Not Applicable
18 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Not Applicable
19 insulin Phase 4,Phase 2,Phase 3,Not Applicable
20 Mydriatics Phase 4
21 Parasympatholytics Phase 4
22 Peripheral Nervous System Agents Phase 4
23 Cholinergic Agents Phase 4
24 Cholinergic Antagonists Phase 4
25 Autonomic Agents Phase 4
26 Neurotransmitter Agents Phase 4
27 Anesthetics Phase 4
28 Adjuvants, Anesthesia Phase 4
29 Antiemetics Phase 4
30 Butylscopolammonium Bromide Phase 4
31 Muscarinic Antagonists Phase 4
32 Bromides Phase 4
33 Anticonvulsants Phase 4
34 Gastrointestinal Agents Phase 4
35 Antiprotozoal Agents Phase 4
36 Renal Agents Phase 4
37 Folic Acid Antagonists Phase 4
38 Folate Phase 4
39 Vitamin B9 Phase 4
40 Antiparasitic Agents Phase 4
41 Anti-Infective Agents, Urinary Phase 4
42 Antimalarials Phase 4
43 Anti-Infective Agents Phase 4,Phase 2
44 Vitamin B Complex Phase 4
45 Fanasil, pyrimethamine drug combination Phase 4
46 Insulin, Isophane Phase 4,Not Applicable
47 Protamines Phase 4
48 Isophane insulin, beef Phase 4,Not Applicable
49 Isophane Insulin, Human Phase 4,Not Applicable
50 Insulin, Short-Acting Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 103)
# Name Status NCT ID Phase Drugs
1 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
2 The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels Unknown status NCT02602301 Phase 4 Oxytocin
3 Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn Infant Unknown status NCT02156050 Phase 4
4 Reverse Phototherapy With Super Light-emitting Diode(Super-LED) for Hyperbilirubinemia in Term and Late Preterm Infants Unknown status NCT01340339 Phase 4
5 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
6 Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
7 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
8 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
9 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4 Oxytocin;Placebo
10 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
11 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
12 Efficacy and Safety of Stannsoporfin in Neonates Completed NCT02685137 Phase 3 stannsoporfin
13 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide
14 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
15 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Recruiting NCT03266913 Phase 3 Probiotic
16 Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section Recruiting NCT03463993 Phase 3 Tranexamic Acid;Oxytocin
17 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Active, not recruiting NCT01222247 Phase 3 Betamethasone;Placebo
18 Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial Completed NCT00692224 Phase 1, Phase 2 zinc gluconate;placebo
19 Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates With Hyperbilirubinemia Completed NCT01887327 Phase 2 stannsoporfin;Placebo
20 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727 Phase 1, Phase 2
21 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
22 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
23 Ceftriaxone and Jaundice in Neonates Recruiting NCT03133637 Phase 2 ceftriaxone
24 A Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia Terminated NCT00850993 Phase 2 stannsoporfin
25 Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment. Unknown status NCT02224586
26 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
27 Cycled Phototherapy: A Safer Effective Treatment for Small Premature Infants? Unknown status NCT01944696 Not Applicable
28 Effect of Umbilical Cord Milking on Iron Related Health Outcomes for Cesarean-Delivered Infants Unknown status NCT02892461 Not Applicable
29 Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy on Oxidative Stress Among Neonates With Unconjugated Hyperbilirubinemia Unknown status NCT03074292 Not Applicable
30 Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform. Unknown status NCT00154960
31 One Step Versus Two Step Approach for Gestational Diabetes Mellitus Screening Unknown status NCT03073330 Not Applicable
32 Point-of-Care System for Determination of Bilirubin Capacity in Neonates Unknown status NCT02612207
33 A Lifestyle Intervention to Improve in Vitro Fertilization Results Unknown status NCT02648555 Not Applicable
34 Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho Completed NCT03306004
35 Implementation of a Transcutaneous Bilirubinometer Completed NCT01622699 Not Applicable
36 Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes Completed NCT02154165 Not Applicable
37 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810 Not Applicable
38 Effectiveness, Safety and Perceptions With the Use of One LED Sleeping Bag Device in the Treatment of Neonatal Jaundice Completed NCT03570775 Not Applicable
39 Implementation of a Clinical Decision Rule for Treatment of Neonatal Jaundice in the Emergency Department Completed NCT02446951
40 Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns Completed NCT02613676 Not Applicable
41 Effectiveness, Safety and Perceptions With the Use of One LED Blanket Device in the Ambulatory Treatment of Jaundice Completed NCT03569254 Not Applicable
42 Efficacy Study of the Draeger Jaundice Meter (JM-105) in Neonates of ≥ 24 Weeks of Gestational Age Completed NCT02774434 Not Applicable
43 BEST ABCs: Benefits and Effectiveness of Support Offered Through A Breastfeeding Clinic Study Completed NCT02043119 Not Applicable
44 The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion Completed NCT02625688 Not Applicable
45 Does Maternal Instruction Prevent Kernicterus in Nigeria? Completed NCT02713464 Not Applicable
46 Transcutaneous Measurement of Jaundice in the Newborn Completed NCT01169740
47 Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of Life Completed NCT02927093
48 The Relation Between Vitamin D and Gestational Diabetes Mellitus Completed NCT03665974
49 Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort Completed NCT01862211 Not Applicable
50 Glycerin Suppositories to Reduce Jaundice in Premature Infants Completed NCT01746511 Not Applicable glycerin suppository

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

42
Skin, Eye, Breast, Liver, Bone, Brain, Testes

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 801)
# Title Authors Year
1
Thiol-Disulfide Homeostasis, Serum Ferroxidase Activity, and Serum Ischemia Modified Albumin Levels in Neonatal Jaundice. ( 30741063 )
2019
2
Corrigendum to "Filtered sunlight, solar powered phototherapy and other strategies for managing neonatal jaundice in low-resource settings" [Early Hum. Dev. 114 (2017 Nov) 11-15]. ( 30292531 )
2019
3
Neonatal Jaundice. ( 30790186 )
2019
4
Preventive effect of purgative manna on neonatal jaundice: A double blind randomized controlled clinical trial. ( 30853647 )
2019
5
Direct bilirubin levels observed in prolonged neonatal jaundice: a retrospective cohort study. ( 29637188 )
2018
6
Neonatal Jaundice: Improved Quality and Cost Savings After Implementation of a Standard Pathway. ( 29467276 )
2018
7
Where do we stand in the field of neonatal jaundice? Commentary on the 2017 J. Donald Ostrow Trieste Yellow Retreat. ( 29718006 )
2018
8
Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana. ( 29686715 )
2018
9
The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. ( 29474382 )
2018
10
The Contribution of Neonatal Jaundice to Global Child Mortality: Findings From the GBD 2016 Study. ( 29305393 )
2018
11
The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. ( 29781686 )
2018
12
Outcomes of neonatal jaundice in Taiwan. ( 29472193 )
2018
13
Clinical and biochemical characteristics of infants with prolonged neonatal jaundice. ( 29807952 )
2018
14
Yinzhihuang oral liquid combined with phototherapy for neonatal jaundice: a systematic review and meta-analysis of randomized clinical trials. ( 30055615 )
2018
15
Optimal Thermal Control with Sufficient Nutrition May Reduce the Incidence of Neonatal Jaundice by Preventing Body-Weight Loss Among Non-Low Birth Weight Infants Not Admitted to Neonatal Intensive Care Unit. ( 30134245 )
2018
16
Risk Factors Associated with Neonatal Jaundice: A Cross-Sectional Study from Iran. ( 30159062 )
2018
17
Sunlight phototherapy for neonatal jaundice-time for its day in the sun? ( 30170895 )
2018
18
Meconium microbiome associates with the development of neonatal jaundice. ( 30237489 )
2018
19
Does Urinary Tract Ultrasound Have Its Place in the Treatment of Early Neonatal Jaundice? Neonatal Bilateral Adrenal Hemorrhage: Case Report. ( 30256026 )
2018
20
A comparison of the effectiveness of three LED phototherapy machines, single- and double-sided, for treating neonatal jaundice in a low resource setting. ( 30308024 )
2018
21
Hereditary stomatocytosis: an unusual cause of severe neonatal jaundice. ( 30310921 )
2018
22
Maternal risk factors for neonatal jaundice: a hospital-based cross-sectional study in Tehran. ( 30344979 )
2018
23
Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice. ( 29119594 )
2017
24
Filtered sunlight, solar powered phototherapy and other strategies for managing neonatal jaundice in low-resource settings. ( 28919246 )
2017
25
Use of a Smartphone App to Assess Neonatal Jaundice. ( 28842403 )
2017
26
The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, double-blind clinical trial. ( 28688960 )
2017
27
Ocular findings on follow-up in children who received phototherapy for neonatal jaundice. ( 28919296 )
2017
28
Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings. ( 29203650 )
2017
29
The influence of zinc sulfate on neonatal jaundice: a systematic review and meta-analysis. ( 28372469 )
2017
30
Burden of severe neonatal jaundice: a systematic review and meta-analysis. ( 29637134 )
2017
31
Neonatal jaundice: aetiology, diagnosis and treatment. ( 29240507 )
2017
32
Effectiveness of transcutaneous bilirubin measurement in managing neonatal jaundice in postnatal ward of a tertiary care hospital in Pakistan. ( 29637112 )
2017
33
Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis. ( 28713275 )
2017
34
Nursing Diagnosis of Neonatal Jaundice: Study of Clinical Indicators. ( 29248302 )
2017
35
Clinical practices among healthcare professionals concerning neonatal jaundice and pale stools. ( 28083674 )
2017
36
Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer. ( 28837635 )
2017
37
Neonatal jaundice: more than a number. ( 28343534 )
2017
38
Phototherapy is commonly used for neonatal jaundice but greater control is needed to avoid toxicity in the most vulnerable infants. ( 29119603 )
2017
39
Primary health workers' knowledge and practices relating to neonatal jaundice in Ibadan, Nigeria. ( 28155287 )
2017
40
Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections. ( 28469520 )
2017
41
Correspondence: Hordeum Vulgare in Neonatal Jaundice. ( 28969234 )
2017
42
Sensitivity, Specificity, and Accuracy of Kramer Examination of Neonatal Jaundice: Comparison with Total Bilirubin Serum. ( 29166181 )
2017
43
Umbilical cord bilirubin as a predictor of neonatal jaundice: a retrospective cohort study. ( 28931391 )
2017
44
Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis. ( 27937684 )
2017
45
The Association of Breastfeeding Practices with Neonatal Jaundice. ( 29911780 )
2017
46
Prolonged neonatal jaundice and urinary tract infection. ( 27989001 )
2016
47
Phototherapy for the Treatment of Neonatal Jaundice and Breastfeeding Duration and Exclusivity. ( 27057645 )
2016
48
Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. ( 27172942 )
2016
49
Perceptions, practices, and traditional beliefs related to neonatal jaundice among Egyptian mothers: A cross-sectional descriptive study. ( 27603393 )
2016
50
A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy. ( 27306191 )
2016

Variations for Neonatal Jaundice

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

GO Terms for Neonatal Jaundice

Cellular components related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.26 G6PD HMOX1 HMOX2 UGT1A1
2 cytoplasmic side of plasma membrane GO:0009898 8.62 G6PD SPTA1

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular iron ion homeostasis GO:0006879 9.46 HMOX1 HMOX2
2 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 HMOX1 IL6
3 glutathione metabolic process GO:0006749 9.4 G6PD GSTM1
4 acute-phase response GO:0006953 9.37 IL6 UGT1A1
5 response to hypoxia GO:0001666 9.33 HMOX1 HMOX2 PKLR
6 iron ion homeostasis GO:0055072 9.32 HMOX1 HMOX2
7 regulation of angiogenesis GO:0045765 9.26 HMOX1 IL6
8 heme oxidation GO:0006788 8.96 HMOX1 HMOX2
9 heme catabolic process GO:0042167 8.8 HMOX1 HMOX2 UGT1A1

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Neonatal Jaundice

3 CDC
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20 FMA
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31 HGMD
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33 HPO
34 ICD10
35 ICD10 via Orphanet
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
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75 UMLS via Orphanet
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