MCID: NNT012
MIFTS: 51

Neonatal Jaundice

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to kernicterus and pyruvate kinase deficiency of red cells, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glucose / Energy Metabolism and Porphyrin and chlorophyll metabolism. The drugs Pyrimethamine and Sulfadoxine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and liver.

Wikipedia : 76 Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 kernicterus 32.9 G6PD UGT1A1
2 pyruvate kinase deficiency of red cells 32.6 G6PD PKLR
3 glucosephosphate dehydrogenase deficiency 29.9 G6PD SLCO1B1 UGT1A1
4 gilbert syndrome 29.9 G6PD SLCO1B1 UGT1A1
5 hereditary spherocytosis 28.5 G6PD PKLR SPTA1 UGT1A1
6 sialuria 11.0
7 bile acid synthesis defect, congenital, 4 10.8
8 niemann-pick disease, type c1 10.8
9 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.8
10 immunodeficiency 47 10.8
11 north american indian childhood cirrhosis 10.8
12 bile acid synthesis defect, congenital, 1 10.8
13 alpha-1-antitrypsin deficiency 10.8
14 peroxisome biogenesis disorder 10b 10.8
15 congenital nonspherocytic hemolytic anemia 10.6 G6PD PKLR
16 irinotecan toxicity 10.5 SLCO1B1 UGT1A1
17 pigmentation disease 10.4 SLCO1B1 UGT1A1
18 hyperbilirubinemia, transient familial neonatal 10.4
19 arteriovenous fistula 10.2 HMOX1 IL6
20 plasmodium vivax malaria 10.2 G6PD IL6
21 nodular malignant melanoma 10.0 HMOX1 HMOX2
22 senile cataract 10.0 G6PD GSTM1
23 biliary atresia 9.9
24 intrahepatic cholestasis 9.9 NR1I3 SLCO1B1 UTP4
25 cholestasis 9.9 NR1I3 SLCO1B1 UTP4
26 ischemic optic neuropathy 9.9 G6PD GSTM1
27 autism 9.8
28 aging 9.8
29 burns 9.8
30 hepatitis 9.8
31 athetosis 9.8
32 cytomegalic inclusion disease 9.8
33 asbestosis 9.7 GSTM1 IL6
34 congenital hemolytic anemia 9.6 G6PD PKLR SPTA1
35 cataract 5, multiple types 9.6
36 attention deficit-hyperactivity disorder 9.6
37 septooptic dysplasia 9.6
38 crigler-najjar syndrome, type i 9.6
39 cystic fibrosis 9.6
40 dubin-johnson syndrome 9.6
41 asthma 9.6
42 allergic rhinitis 9.6
43 beta-thalassemia 9.6
44 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.6
45 cataract 9.6
46 liver disease 9.6
47 newborn respiratory distress syndrome 9.6
48 thalassemia 9.6
49 autism spectrum disorder 9.6
50 sensorineural hearing loss 9.6

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


icterus, newborn physiological jaundice

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
5 Adjuvants, Anesthesia Phase 4
6 Anesthetics Phase 4
7 Anticonvulsants Phase 4
8 Autonomic Agents Phase 4
9 Bromides Phase 4
10 Butylscopolammonium Bromide Phase 4
11 Cholinergic Agents Phase 4
12 Cholinergic Antagonists Phase 4
13 Muscarinic Antagonists Phase 4
14 Mydriatics Phase 4
15 Neurotransmitter Agents Phase 4
16 Parasympatholytics Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Scopolamine hydrobromide Phase 4 114-49-8
19 Anti-Infective Agents Phase 4,Phase 2
20 Antimalarials Phase 4
21 Antiparasitic Agents Phase 4
22 Antiprotozoal Agents Phase 4
23 Fanasil, pyrimethamine drug combination Phase 4
24 Folic Acid Antagonists Phase 4
25 Renal Agents Phase 4
26 Vitamin B Complex Phase 4
27 Folate Nutraceutical Phase 4
28 Vitamin B9 Nutraceutical Phase 4
29
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
30
Zinc Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 7440-66-6 23994
31 Hypoglycemic Agents Phase 2, Phase 3,Not Applicable
32 insulin Phase 2, Phase 3,Not Applicable
33 Insulin, Globin Zinc Phase 2, Phase 3,Not Applicable
34
Tin Phase 3,Phase 2 7440-31-5
35 Tin mesoporphyrin Phase 3,Phase 2
36
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
37
Bilirubin Phase 1, Phase 2,Not Applicable 635-65-4 5280352
38 Antioxidants Phase 1, Phase 2,Not Applicable
39 Micronutrients Phase 1, Phase 2
40 Protective Agents Phase 1, Phase 2,Not Applicable
41 Trace Elements Phase 1, Phase 2
42 Anti-Bacterial Agents Phase 2
43
Menthol Approved Not Applicable 2216-51-5 16666
44
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
45
Glycerol Approved, Investigational Not Applicable 56-81-5 753
46
Glyburide Approved 10238-21-8 3488
47
Protein C Approved Not Applicable
48
Iron Approved Not Applicable 7439-89-6 23925
49 tannic acid Approved, Nutraceutical Not Applicable
50
Serine Approved, Nutraceutical Not Applicable 56-45-1 5951

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Safety Study of Hyoscine N Butyl Bromide in Active Management of Labor Completed NCT02098889 Phase 4 hyoscine-N-butyl bromide(HBB);Saline
2 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
3 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
4 Efficacy and Safety of Stannsoporfin in Neonates Completed NCT02685137 Phase 3 stannsoporfin
5 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Recruiting NCT03266913 Phase 3 Probiotic
6 Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section Recruiting NCT03463993 Phase 3 Tranexamic Acid;Oxytocin
7 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810 Phase 1, Phase 2
8 Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial Completed NCT00692224 Phase 1, Phase 2 zinc gluconate;placebo
9 Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates With Hyperbilirubinemia Completed NCT01887327 Phase 2 stannsoporfin;Placebo
10 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727 Phase 1, Phase 2
11 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
12 Ceftriaxone and Jaundice in Neonates Recruiting NCT03133637 Phase 2 ceftriaxone
13 Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment. Unknown status NCT02224586
14 Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study) Unknown status NCT02361788
15 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
16 Cycled Phototherapy: A Safer Effective Treatment for Small Premature Infants? Unknown status NCT01944696 Not Applicable
17 Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho Completed NCT03306004
18 Implementation of a Transcutaneous Bilirubinometer Completed NCT01622699 Not Applicable
19 Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes Completed NCT02154165 Not Applicable
20 Effectiveness, Safety and Perceptions With the Use of One LED Sleeping Bag Device in the Treatment of Neonatal Jaundice Completed NCT03570775 Not Applicable
21 Implementation of a Clinical Decision Rule for Treatment of Neonatal Jaundice in the Emergency Department Completed NCT02446951
22 Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns Completed NCT02613676 Not Applicable
23 Effectiveness, Safety and Perceptions With the Use of One LED Blanket Device in the Ambulatory Treatment of Jaundice Completed NCT03569254 Not Applicable
24 BEST ABCs: Benefits and Effectiveness of Support Offered Through A Breastfeeding Clinic Study Completed NCT02043119 Not Applicable
25 The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion Completed NCT02625688 Not Applicable
26 Does Maternal Instruction Prevent Kernicterus in Nigeria? Completed NCT02713464 Not Applicable
27 Transcutaneous Measurement of Jaundice in the Newborn Completed NCT01169740
28 Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of Life Completed NCT02927093
29 Glycerin Suppositories to Reduce Jaundice in Premature Infants Completed NCT01746511 Not Applicable glycerin suppository
30 Effects of Probiotics on Neonatal Hyperbilirubinemia Completed NCT02807246 Not Applicable
31 Transcutaneous Bilirubinometers in the Community Completed NCT00735319 Not Applicable
32 Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries Completed NCT01754688
33 Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana Completed NCT02468310 Not Applicable
34 Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review Completed NCT01998113 Glyburide vs Insulin trials;Metformin vs Insulin trials;Metformin vs Glyburide trials
35 Umbilical Cord Milking on the Reduction of Red Blood Cell Transfusion Rates in Infants Completed NCT01523769 Not Applicable
36 A Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice Recruiting NCT03055481 Not Applicable
37 Comparison of the Efficacy of Phototherapy Using Blue LED's With Wavelength 478 vs. 459 nm. Recruiting NCT03183986 Not Applicable
38 Evaluation of a Smartphone Based Optical Diagnostic Tool for Neonatal Jaundice Recruiting NCT03007563 Not Applicable
39 Unbound Bilirubin Levels in Healthy Term and Late Preterm Infants Recruiting NCT03237715
40 Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort Recruiting NCT01862211 Not Applicable
41 Intrapartum Glucose and Insulin Compared to Glucose Alone in Diabetic Women Recruiting NCT03273881 Not Applicable glucose solution and Insulin;glucose solution only
42 Group Versus Traditional Prenatal Care for Diabetes Recruiting NCT03301792 Not Applicable
43 Effect of Umbilical Cord Milking on Iron Related Health Outcomes for Cesarean-Delivered Infants Recruiting NCT02892461 Not Applicable
44 Blood Pressure, Antihypertensive Treatment and Preeclampsia in Pregnant Wom-en With Pre-existing Diabetes Recruiting NCT02890836 Antihypertensiva, mainly Metyldopa
45 Understanding Neonatal Jaundice in Rwanda Active, not recruiting NCT03184948 Not Applicable
46 Efficacy Study of the Draeger Jaundice Meter (JM-105) in Neonates of ≥ 24 Weeks of Gestational Age Active, not recruiting NCT02774434 Not Applicable
47 Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment Active, not recruiting NCT02222805 Not Applicable
48 Diabetes Mellitus With Pregnancy in Benisuef Localities Enrolling by invitation NCT03169205
49 Compassionate Use of Stanate (TM) [Stannsoporfin] No longer available NCT00076960 Stanate (TM) [stannsoporfin, tin-mesoporphyrin]

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

41
Skin, Eye, Liver, Brain, Colon

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 595)
# Title Authors Year
1
Direct bilirubin levels observed in prolonged neonatal jaundice: a retrospective cohort study. ( 29637188 )
2018
2
Neonatal Jaundice: Improved Quality and Cost Savings After Implementation of a Standard Pathway. ( 29467276 )
2018
3
Where do we stand in the field of neonatal jaundice? Commentary on the 2017 J. Donald Ostrow Trieste Yellow Retreat. ( 29718006 )
2018
4
Knowledge Level and Determinants of Neonatal Jaundice: A Cross-Sectional Study in the Effutu Municipality of Ghana. ( 29686715 )
2018
5
The Turkish Neonatal Jaundice Online Registry: A national root cause analysis. ( 29474382 )
2018
6
The Contribution of Neonatal Jaundice to Global Child Mortality: Findings From the GBD 2016 Study. ( 29305393 )
2018
7
The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. ( 29781686 )
2018
8
Outcomes of neonatal jaundice in Taiwan. ( 29472193 )
2018
9
Clinical and biochemical characteristics of infants with prolonged neonatal jaundice. ( 29807952 )
2018
10
Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice. ( 29119594 )
2017
11
Filtered sunlight, solar powered phototherapy and other strategies for managing neonatal jaundice in low-resource settings. ( 28919246 )
2017
12
Use of a Smartphone App to Assess Neonatal Jaundice. ( 28842403 )
2017
13
The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, double-blind clinical trial. ( 28688960 )
2017
14
Ocular findings on follow-up in children who received phototherapy for neonatal jaundice. ( 28919296 )
2017
15
Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings. ( 29203650 )
2017
16
The influence of zinc sulfate on neonatal jaundice: a systematic review and meta-analysis. ( 28372469 )
2017
17
Burden of severe neonatal jaundice: a systematic review and meta-analysis. ( 29637134 )
2017
18
Neonatal jaundice: aetiology, diagnosis and treatment. ( 29240507 )
2017
19
Effectiveness of transcutaneous bilirubin measurement in managing neonatal jaundice in postnatal ward of a tertiary care hospital in Pakistan. ( 29637112 )
2017
20
Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis. ( 28713275 )
2017
21
Nursing Diagnosis of Neonatal Jaundice: Study of Clinical Indicators. ( 29248302 )
2017
22
Clinical practices among healthcare professionals concerning neonatal jaundice and pale stools. ( 28083674 )
2017
23
Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer. ( 28837635 )
2017
24
Neonatal jaundice: more than a number. ( 28343534 )
2017
25
Phototherapy is commonly used for neonatal jaundice but greater control is needed to avoid toxicity in the most vulnerable infants. ( 29119603 )
2017
26
Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections. ( 28469520 )
2017
27
Correspondence: Hordeum Vulgare in Neonatal Jaundice. ( 28969234 )
2017
28
Sensitivity, Specificity, and Accuracy of Kramer Examination of Neonatal Jaundice: Comparison with Total Bilirubin Serum. ( 29166181 )
2017
29
Umbilical cord bilirubin as a predictor of neonatal jaundice: a retrospective cohort study. ( 28931391 )
2017
30
Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis. ( 27937684 )
2017
31
Prolonged neonatal jaundice and urinary tract infection. ( 27989001 )
2016
32
Phototherapy for the Treatment of Neonatal Jaundice and Breastfeeding Duration and Exclusivity. ( 27057645 )
2016
33
Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. ( 27172942 )
2016
34
Perceptions, practices, and traditional beliefs related to neonatal jaundice among Egyptian mothers: A cross-sectional descriptive study. ( 27603393 )
2016
35
A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy. ( 27306191 )
2016
36
The study on clinical value of the detection about serum and Unconjugated Bilirubin in diagnosis of neonatal jaundice. ( 27005510 )
2016
37
A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand-Myanmar Border. ( 27576869 )
2016
38
Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation. ( 26693676 )
2016
39
The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature. ( 26755212 )
2016
40
Management of neonatal jaundice in primary care. ( 28461853 )
2016
41
Neonatal jaundice. ( 27387624 )
2016
42
The effect of Cotoneaster manna on neonatal jaundice: A PRISMA-compliant systematic review. ( 27976153 )
2016
43
Haemolytic and non-haemolytic neonatal jaundice have different risk factor profiles. ( 27173507 )
2016
44
Effects of baby massage on neonatal jaundice in healthy Iranian infants: A pilot study. ( 26646074 )
2016
45
Ethnomedicine for neonatal jaundice: A cross-sectional survey in Qom, Iran. ( 27721052 )
2016
46
Neonatal jaundice. ( 27353908 )
2016
47
Effect of phototherapy on B and T lymphocytes in Egyptian infants suffering from neonatal jaundice. ( 27890454 )
2016
48
Cotoneaster: A Safe and Easy Way to Reduce Neonatal Jaundice. ( 27190910 )
2016
49
Risk profiles for haemolytic and nonhaemolytic neonatal jaundice. ( 27870210 )
2016
50
Neonatal Jaundice with Splenomegaly: Not a Common Pick. ( 26847548 )
2016

Variations for Neonatal Jaundice

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

Pathways related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.19 G6PD HMOX2 UGT1A1
2
Show member pathways
11.96 HMOX1 HMOX2 UGT1A1
3
Show member pathways
11.26 NR1I3 UGT1A1
4
Show member pathways
11.24 SLCO1B1 UGT1A1
5 11.18 HMOX1 HMOX2
6 11.09 G6PD GSTM1 HMOX1 UGT1A1
7
Show member pathways
11.04 SLCO1B1 UGT1A1
8 10.95 HMOX1 IL6
9
Show member pathways
10.9 GSTM1 UGT1A1
10 10.85 HMOX1 IL6
11 10.76 NR1I3 UGT1A1
12 10.43 HMOX1 IL6
13 10.19 NR1I3 SLCO1B1

GO Terms for Neonatal Jaundice

Cellular components related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 G6PD SPTA1

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 HMOX1 IL6
2 glutathione metabolic process GO:0006749 9.4 G6PD GSTM1
3 iron ion homeostasis GO:0055072 9.37 HMOX1 HMOX2
4 response to hypoxia GO:0001666 9.33 HMOX1 HMOX2 PKLR
5 regulation of angiogenesis GO:0045765 9.32 HMOX1 IL6
6 acute-phase response GO:0006953 9.26 IL6 UGT1A1
7 heme oxidation GO:0006788 8.96 HMOX1 HMOX2
8 heme catabolic process GO:0042167 8.8 HMOX1 HMOX2 UGT1A1

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Neonatal Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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