MCID: NNT012
MIFTS: 53

Neonatal Jaundice

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to glucosephosphate dehydrogenase deficiency and gilbert syndrome, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Th17 cell differentiation. The drugs Oxytocin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 glucosephosphate dehydrogenase deficiency 32.8 UGT1A1 SLCO1B1 PKLR G6PD
2 gilbert syndrome 30.8 UGT1A1 SLCO1B1 HMOX1 G6PD
3 pain agnosia 30.5 OXT IL6 IL1B
4 eclampsia 30.3 TNF OXT IL6
5 hereditary spherocytosis 30.2 UGT1A1 SPTA1 PKLR G6PD
6 hemoglobinopathy 30.2 UGT1A1 G6PD BTD
7 chickenpox 30.2 TNF IL6 IL10
8 conjunctivitis 30.1 TNF IL6 IL10
9 acute cystitis 30.0 TNF IL6 IL1B IL10
10 hepatitis a 30.0 TNF IL1B IL10
11 bilirubin metabolic disorder 29.9 UGT1A1 SLCO1B1 OXT NR1I3 HMOX1 G6PD
12 perinatal necrotizing enterocolitis 29.9 TNF IL6 IL1B IL10
13 cytomegalovirus infection 29.9 TNF IL6 IL1B
14 exanthem 29.9 TNF IL6 IL1B IL10
15 toxoplasmosis 29.9 TNF IL6 IL1B IL10
16 rhinitis 29.8 TNF IL6 IL1B IL10
17 liver disease 29.8 UGT1A1 TNF IL6 IL1B HSD3B7
18 cerebral palsy 29.8 TNF IL6 IL1B IL10
19 pertussis 29.7 TNF IL6 IL1B IL10
20 otitis media 29.7 TNF IL6 IL1B IL10
21 leprosy 3 29.6 TNF IL6 IL1B IL10
22 gaucher's disease 29.5 TNF PKLR IL6
23 bacterial sepsis 29.5 TNF IL6 IL1B IL10
24 bacterial infectious disease 29.5 TNF IL6 IL1B IL10
25 salmonellosis 29.5 TNF IL6 IL1B IL10
26 mumps 29.5 TNF IL6 IL1B IL10
27 rubella 29.5 TNF IL6 IL1B IL10
28 respiratory failure 29.5 TNF IL6 IL1B IL10 G6PD
29 toxic shock syndrome 29.5 TNF IL6 IL1B IL10
30 deficiency anemia 29.5 TNF IL6 HMOX1 GSTM1 G6PD
31 viral hepatitis 29.3 TNF IL6 IL1B IL10 G6PD
32 dermatitis 29.3 TNF IL6 IL1B IL10 BTD
33 cholestasis 29.2 UTP4 TNF SLCO1B1 NR1I3 JAG1 IL6
34 pre-eclampsia 29.1 TNF OXT IL6 IL1B IL10 HMOX1
35 disseminated intravascular coagulation 28.9 TNF IL6 IL10 ADAMTS13
36 cystic fibrosis 28.9 TNF IL6 IL1B IL10 HMOX1
37 hemolytic anemia 28.6 UGT1A1 TNF SPTA1 PKLR IL10 HMOX1
38 diarrhea 28.4 UGT1A1 TNF IL6 IL1B IL10 ADAMTS13
39 kernicterus 11.8
40 pyruvate kinase deficiency of red cells 11.5
41 anemia, nonspherocytic hemolytic, due to g6pd deficiency 11.5
42 alpha-1-antitrypsin deficiency 11.4
43 sialuria 11.3
44 north american indian childhood cirrhosis 11.3
45 stomatin-deficient cryohydrocytosis with neurologic defects 11.3
46 bamforth syndrome 11.3
47 bile acid synthesis defect, congenital, 4 11.1
48 niemann-pick disease, type c1 11.1
49 immunodeficiency 47 11.1
50 bile acid synthesis defect, congenital, 1 11.1

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


icterus, newborn physiological jaundice

MGI Mouse Phenotypes related to Neonatal Jaundice:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 BTD G6PD HMOX1 HMOX2 HSD3B7 IL10
2 homeostasis/metabolism MP:0005376 10.22 ADAMTS13 BTD G6PD HMOX1 HMOX2 HSD3B7
3 cardiovascular system MP:0005385 10.16 G6PD HMOX1 HMOX2 IL10 IL1B IL6
4 hematopoietic system MP:0005397 10.15 ADAMTS13 G6PD HMOX1 HMOX2 IL10 IL1B
5 digestive/alimentary MP:0005381 10.03 HMOX2 HSD3B7 IL10 IL6 JAG1 OXT
6 integument MP:0010771 10 BTD HMOX2 HSD3B7 IL10 IL1B IL6
7 mortality/aging MP:0010768 9.83 ADAMTS13 G6PD HMOX1 HMOX2 HSD3B7 IL10
8 liver/biliary system MP:0005370 9.76 HMOX1 HSD3B7 IL10 IL6 JAG1 NR1I3
9 nervous system MP:0003631 9.36 G6PD HMOX2 IL10 IL1B IL6 JAG1

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
2
leucovorin Approved Phase 4 58-05-9 6006 143
3
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
4
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
5
Metformin Approved Phase 4 657-24-9 14219 4091
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
7 Vitamin B Complex Phase 4
8 Folic Acid Antagonists Phase 4
9 Fanasil, pyrimethamine drug combination Phase 4
10 Antiprotozoal Agents Phase 4
11 Antiparasitic Agents Phase 4
12 Folate Phase 4
13 Vitamin B9 Phase 4
14 Antimalarials Phase 4
15
Scopolamine Approved, Investigational Phase 3 6533-68-2, 51-34-3 5184
16
Amodiaquine Approved, Investigational Phase 3 86-42-0 2165
17
Artesunate Approved, Investigational Phase 3 88495-63-0 6917864 5464098
18
Nifedipine Approved Phase 3 21829-25-4 4485
19
Piperaquine Experimental, Investigational Phase 3 4085-31-8 5079497
20
Dihydroartemisinin Experimental, Investigational Phase 3 71939-50-9 6918483
21 Gastrointestinal Agents Phase 3
22 Parasympatholytics Phase 3
23 Cholinergic Agents Phase 3
24 Antiemetics Phase 3
25 Muscarinic Antagonists Phase 3
26 Mydriatics Phase 3
27 Anticonvulsants Phase 3
28 Anesthetics Phase 3
29 Bromides Phase 3
30 Butylscopolammonium Bromide Phase 3
31 Cholinergic Antagonists Phase 3
32 Neurotransmitter Agents Phase 3
33 Tin mesoporphyrin Phase 3
34 Anthelmintics Phase 3
35 Hormones Phase 3
36 Vasodilator Agents Phase 3
37 Calcium, Dietary Phase 3
38 calcium channel blockers Phase 3
39 Tocolytic Agents Phase 3
40
Calcium Nutraceutical Phase 3 7440-70-2 271
41
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051
42
Ceftriaxone Approved Phase 2 73384-59-5 5361919 5479530
43
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
44
Cysteine Approved, Nutraceutical Phase 1, Phase 2 52-90-4 5862
45 Antioxidants Phase 1, Phase 2
46 Protective Agents Phase 1, Phase 2
47 Immunoglobulins Phase 2
48 Antibodies Phase 2
49 Anti-Bacterial Agents Phase 2
50 Respiratory System Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 106)
# Name Status NCT ID Phase Drugs
1 Efficacy of Reverse Phototherapy With Super Light-emitting Diode(Super-led) in Term and Late Preterm Infants:Randomized and Controlled Clinical Trial Unknown status NCT01340339 Phase 4
2 Utilisation du Dispositif BBloo® Pour le Traitement de l'ictère néonatal : Satisfaction Des Parents et Des Personnels Soignants Unknown status NCT02156050 Phase 4
3 A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
4 The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels .A Prospective Randomized Controlled Trial. Unknown status NCT02602301 Phase 4 Oxytocin
5 Intermittent Preventive Treatment of Malaria With Sulfadoxine-Pyrimethamine in HIV-Seropositive and HIV-Seronegative Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
6 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes: A Single Site Randomized Trial Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
7 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
8 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Unknown status NCT03266913 Phase 3 Probiotic
9 Use of Hyoscine Butyl Bromide for Management of Prolonged Labor in Nulliparous Women, A Randomized Controlled Trial Unknown status NCT01854073 Phase 3 Hyoscine butyl bromide;Normal saline
10 A Randomized Trial of Aggressive or Conservative Phototherapy for Extremely Low Birth Weight Infants Completed NCT00114543 Phase 3
11 A Multicenter Study to Evaluate the Efficacy and Safety of Tin Mesoporphyrin (Stannsoporfin) to Reduce the Need for Phototherapy in Term and Near Term Infants. Completed NCT02685137 Phase 3 stannsoporfin
12 Minimally Invasive Management of Rh Alloimmunization: Can Amniotic Fluid DeltaOD450 Measurements Be Replaced by Doppler Studies? Completed NCT00295516 Phase 3
13 Efficacy, Safety and Tolerability of Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Falciparum Malaria in Pregnancy: an Open-label, Randomised Controlled, Non-inferiority Trial Completed NCT01231113 Phase 3 artesunate-amodiaquine;Dihydroartemisinin-piperaquine
14 Study of Different Doses of Nifedipine to Treat Preterm Labor Terminated NCT00137501 Phase 3 Nifedipine
15 A Phase 2b Multicenter, Single Dose, Randomized, Double Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates Completed NCT01887327 Phase 2 Stannsoporfin;Placebo
16 Effect of Oral Zinc Given Daily Between Days 2 and 7 of Life to Term or Near Term Neonates With Serum Bilirubin Levels of More Than 6 mg/dL at 24 ± 6 Hours of Life on Hyperbilirubinemia and Phototherapy Completed NCT00692224 Phase 1, Phase 2 zinc gluconate;placebo
17 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2 tin mesoporphyrin
18 Improvement in Gross Motor Function and Muscle Tone in Children With Cerebral Palsy Related to Neonatal Icterus: An Open-label, Uncontrolled Clinical Trial Completed NCT03123562 Phase 2
19 An Open-Label Study of the Safety and Clinical Pharmacology of Stanate® in Infants At-Risk for Exchange Transfusion Completed NCT00115544 Phase 2 Stanate
20 Effect of Ceftriaxone on Neonatal Jaundice Completed NCT03133637 Phase 2 ceftriaxone
21 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants at Birth and Three Months of Age Completed NCT01081977 Phase 2
22 Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine Completed NCT00975689 Phase 1, Phase 2 N-Acetyl Cysteine
23 A Phase 2b, Multicenter, Single-dose, Blinded, Randomized, Placebo-controlled, Dose-escalation, Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia Terminated NCT00850993 Phase 2 Stannsoporfin
24 A Prospective Multicenter Non-inferiority Randomized Controlled Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice Unknown status NCT03055481
25 Point-of-Care System for Determination of Bilirubin Capacity in Neonates Unknown status NCT02612207
26 Unbound Bilirubin Levels in Healthy Term and Late Preterm Infants Unknown status NCT03237715
27 Comparison of the Efficacy of Phototherapy With Wavelength 478 vs. 459 nm for Treatment of Neonatal Jaundice Using Blue LED's. Unknown status NCT03183986
28 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis in ABO-compatible and Incompatible Healthy Term Newborn Infants. Unknown status NCT00917007
29 Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy on Oxidative Stress Among Neonates With Unconjugated Hyperbilirubinemia Unknown status NCT03074292
30 Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform. Unknown status NCT00154960
31 Complications of Exchange Transfusion in Neonates Unknown status NCT03195049
32 Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes Completed NCT02154165
33 Evaluation of a Smartphone Based Optical Diagnostic Tool for Neonatal Jaundice Completed NCT03007563
34 Comparison of Transcutaneous or Laboratory Measurement of Bilirubin in the Newborn Completed NCT01169740
35 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727
36 Transcutaneous Bilirubinometers in the Community and the Reduction of Morbidity Associated to Jaundice: A Clustered Randomized Controlled Trial. Completed NCT00735319
37 The Use of Glycerin Suppositories to Reduce Hyperbilirubinemia in Premature Infants Requiring Phototherapy Completed NCT01746511 glycerin suppository
38 Fenofibrate as an Adjuvant to Phototherapy in Pathological Unconjugated Hyperbilirubinemia in Full Term Infants: A Randomized Control Trial. Completed NCT04418180 Fenofibrate;Placebo
39 Multicenter Prospective Study on the Incidence and Risk Factors of Neonatal Hyperbilirubinemia in Term and Late-preterm Chinese Infants Completed NCT01762189
40 The Predictors of the Neonatal Hyperbilirubinemia Completed NCT00154999
41 Aluminium Foil as an Adjuvant to Phototherapy for Pathological Unconjugated Hyperbilirubinaemia in Full Term Infants: Randomised Control Trial Completed NCT04433923
42 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810
43 Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho Completed NCT03306004
44 Development of Transcutaneous Bilirubin Nomogram to Identify Neonatal Hyperbilirubinemia in Term and Late-preterm Infants: a Multicenter Study in China Completed NCT01763632
45 Understanding Neonatal Jaundice in Rwanda Completed NCT03184948
46 Implementation of a Transcutaneous Bilirubinometer in Jaundiced Newborns: a Randomised Controlled Trial Completed NCT01622699
47 Conventional Versus LED Phototherapy and Their Effect on Lymphocytes Subsets of Full Term Neonates With Hyperbilirubinemia Completed NCT04373980
48 Is Primiparity a Risk Factor for Neonatal Hyperbilirubinemia? Completed NCT03329040
49 Follow-up of Extreme Neonatal Hyperbilirubinemia in 5-10 Year Old Children: a Danish Population Based Study Completed NCT01599611
50 A Four-Year Blinded Outcomes Follow-up Study of Patients Who Received Stannsoporfin or Placebo in Clinical Trial 64,185-204 Completed NCT02000830 Stannsoporfin;Placebo

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

40
Skin, Breast, Liver, Testes, Eye, Brain, Cortex

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 2254)
# Title Authors PMID Year
1
Glucose-6-phosphate dehydrogenase and red cell pyruvate kinase deficiency in neonatal jaundice cases in egypt. 54 61
20426517 2010
2
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. 54 61
20007901 2009
3
[Relationship between glucose-6-phosphate dehydrogenase gene mutations and neonatal jaundice in Naning, Guangxi]. 61 54
20113600 2009
4
Xenobiotic-sensing nuclear receptors CAR and PXR as drug targets in cholestatic liver disease. 54 61
19925451 2009
5
A prolonged neonatal jaundice associated with a rare G6PD mutation. 61 54
19422023 2009
6
Efficacy of clofibrate on severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency (a randomized clinical trial). 54 61
18564698 2008
7
[Glucose-6-phosphate dehydrogenase deficiency: clinical presentation and eliciting factors]. 61 54
18547022 2008
8
Glucose-6-phosphate dehydrogenase deficiency. 54 61
18177777 2008
9
Cord blood bilirubin level in relation to bilirubin UDP-glucuronosyltransferase gene missense allele in Chinese neonates. 61 54
17888052 2007
10
A review of Orang Asli newborns admitted to a neonatal unit in a Malaysian general hospital. 61 54
17909678 2007
11
Massive acute haemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient preterm triplets. 54 61
17489836 2007
12
The frequency of UDP-glucuronosyltransferase 1A1 promoter region (TA)7 polymorphism in newborns and it's relation with jaundice. 61 54
17166930 2007
13
Glucose-6-phosphate dehydrogenase--from oxidative stress to cellular functions and degenerative diseases. 61 54
17623517 2007
14
Prevalence of G6PD deficiency in newborns in the south of Brazil. 61 54
16792831 2006
15
[Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]. 61 54
16255851 2005
16
Poor correlation between hemolysis and jaundice in glucose 6-phosphate dehydrogenase-deficient babies. 61 54
15910447 2005
17
Neonatal screening of glucose-6-phosphate dehydrogenase deficiency in Yanbu, Saudi Arabia. 54 61
16417692 2005
18
Screening for G71R mutation of the UGT1A1 gene in the Javanese-Indonesian and Malay-Malaysian populations. 54 61
15491385 2004
19
An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates. 61 54
14972648 2004
20
Glucose-6-phosphate dehydrogenase deficiency in neonates. 54 61
14703221 2003
21
Neonatology in Singapore: the way we were, the way forward. 54 61
12854374 2003
22
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). 54 61
12644704 2003
23
Glucose-6-phosphate dehydrogenase (G-6-PD) levels in jaundiced neonates in Calabar. 61 54
12956017 2003
24
Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. 54 61
12552319 2003
25
[Interest in the study of genetic variants of the promoter region of the UGT1A1 gene in neonatal jaundice]. 61 54
11827650 2002
26
Genetic interactions in the pathogenesis of neonatal hyperbilirubinemia: Gilbert's Syndrome and glucose-6-phosphate dehydrogenase deficiency. 61 54
11803413 2001
27
Neonatal jaundice--traditional Chinese medicine approach. 61 54
11803427 2001
28
A novel inhibitor of beta-glucuronidase: L-aspartic acid. 61 54
11568288 2001
29
Onset of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates. 61 54
11581450 2001
30
Low glucose-6-phosphate dehydrogenase enzyme activity level at the time of hemolysis in a male neonate with the African type of deficiency. 54 61
11783956 2001
31
A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns. 54 61
11433050 2001
32
The value of methemoglobin reduction test as a screening test for neonatal glucose 6-phosphate dehydrogenase deficiency. 61 54
11529386 2001
33
[Glucose-6-phosphate dehydrogenase et neonatal jaundice]. 61 54
11317924 2001
34
Molecular characterization of a German variant of glucose-6-phosphate dehydrogenase deficiency (G6PD Aachen). 61 54
10772881 2000
35
Glucose-6-phosphate dehydrogenase (G6PD) variants in Malaysian Chinese. 61 54
10502785 1999
36
A variant TATA box in the bilirubin UDP-glucuronosyltransferase 1 gene promoter does not contribute to neonatal jaundice in the Japanese population. 61 54
10507878 1999
37
Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome. 61 54
10220506 1999
38
Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn. 61 54
10190918 1999
39
Glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Al-Hofuf area. 61 54
17337961 1999
40
Glucose-6-phosphate dehydrogenase deficiency in Thailand; its significance in the newborn. 61 54
11400792 1999
41
Gilbert syndrome accelerates development of neonatal jaundice. 61 54
9580766 1998
42
Two new mutations of the glucose-6-phosphate dehydrogenase (G6PD) gene associated with haemolytic anaemia: clinical, biochemical and molecular relationships. 54 61
9332310 1997
43
[The preliminary study on prevention and treatment of neonatal jaundice]. 61 54
9596945 1997
44
Can severe neonatal jaundice be prevented by neonatal screening for glucose-6-phosphate dehydrogenase deficiency?--a review of evidence. 61 54
8942026 1996
45
G6PD NanKang (517 T-->C; 173 Phe-->Leu): a new Chinese G6PD variant associated with neonatal jaundice. 61 54
8807322 1996
46
G6PD: population genetics and clinical manifestations. 61 54
8861278 1996
47
The negative heritability of neonatal jaundice. 61 54
8835092 1996
48
Neonatal jaundice and molecular mutations in glucose-6-phosphate dehydrogenase deficient newborn infants. 61 54
8571933 1996
49
Enzyme deficiencies in neonates with jaundice. 61 54
8710395 1995
50
Role of hemolysis in neonatal jaundice associated with glucose-6 phosphate dehydrogenase deficiency. 61 54
7472840 1995

Variations for Neonatal Jaundice

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

Pathways related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 TNF SPTA1 OSM IL6 IL1B IL10
2
Show member pathways
12.53 TNF JAG1 IL6 IL1B IL10
3 12.18 TNF IL6 IL1B IL10
4
Show member pathways
12.16 TNF IL6 IL1B IL10
5 12.12 TNF IL6 IL1B IL10
6 12.05 UGT1A1 HMOX1 GSTM1 G6PD
7 12.02 TNF IL1B HMOX1 GSTM1
8 11.93 TNF IL6 IL1B IL10
9 11.87 TNF JAG1 IL6 IL1B
10
Show member pathways
11.84 TNF IL6 IL1B IL10
11 11.8 TNF IL6 IL1B IL10
12 11.72 TNF IL1B IL10
13 11.64 TNF IL6 IL1B IL10
14
Show member pathways
11.61 TNF IL6 IL1B
15 11.6 TNF IL6 IL1B IL10
16 11.56 TNF IL6 IL1B
17 11.5 TNF IL6 IL1B HMOX1
18 11.49 TNF OSM IL6 IL1B IL10 HMOX1
19 11.47 UGT1A1 TNF IL1B
20 11.43 TNF IL6 IL1B
21 11.37 TNF IL6 IL1B IL10
22 11.31 TNF IL6 IL1B IL10
23
Show member pathways
11.27 UGT1A1 SLCO1B1 NR1I3
24 11.24 TNF IL6 IL1B
25 11.2 TNF IL6 IL1B
26 11.13 TNF IL6 IL1B IL10
27 10.93 TNF IL6 HMOX1
28 10.92 TNF IL6 IL1B IL10
29 10.73 IL6 IL1B
30 10.57 TNF IL6 IL1B IL10 HMOX1

GO Terms for Neonatal Jaundice

Cellular components related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TNF OXT OSM JAG1 IL6 IL1B
2 extracellular space GO:0005615 9.28 TNF OXT OSM IL6 IL1B IL10

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.17 TNF OSM NR1I3 JAG1 IL6 IL1B
2 immune response GO:0006955 10.05 TNF OSM IL6 IL1B IL10
3 negative regulation of cell proliferation GO:0008285 10.03 OSM IL6 IL1B IL10 HMOX1
4 hemopoiesis GO:0030097 9.82 SPTA1 JAG1 IL10
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TNF OSM IL6
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 TNF IL6 IL1B IL10
7 positive regulation of T cell proliferation GO:0042102 9.79 SPTA1 IL6 IL1B
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 TNF IL6 HMOX1
9 positive regulation of interleukin-6 production GO:0032755 9.77 TNF IL6 IL1B
10 negative regulation of fat cell differentiation GO:0045599 9.75 TNF JAG1 IL6
11 cytokine-mediated signaling pathway GO:0019221 9.73 TNF OSM IL6 IL1B IL10 HMOX1
12 positive regulation of JAK-STAT cascade GO:0046427 9.69 TNF IL6 IL10
13 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
14 negative regulation of neurogenesis GO:0050768 9.65 TNF IL6 IL1B
15 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
16 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
17 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
18 positive regulation of prostaglandin secretion GO:0032308 9.6 OXT IL1B
19 negative regulation of cytokine production involved in immune response GO:0002719 9.58 TNF IL10
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 TNF IL1B IL10
21 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 TNF IL10
23 sequestering of triglyceride GO:0030730 9.55 TNF IL1B
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 TNF IL1B
25 positive regulation of chemokine biosynthetic process GO:0045080 9.54 TNF IL1B HMOX1
26 receptor biosynthetic process GO:0032800 9.52 TNF IL10
27 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
28 heme oxidation GO:0006788 9.46 HMOX2 HMOX1
29 cellular response to lipopolysaccharide GO:0071222 9.43 TNF NR1I3 IL6 IL1B IL10 ADAMTS13
30 heme catabolic process GO:0042167 9.33 UGT1A1 HMOX2 HMOX1
31 response to glucocorticoid GO:0051384 9.02 UGT1A1 TNF OXT IL6 IL10

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 OSM JAG1 IL6 IL10
2 cytokine activity GO:0005125 9.02 TNF OSM IL6 IL1B IL10
3 heme oxygenase (decyclizing) activity GO:0004392 8.96 HMOX2 HMOX1

Sources for Neonatal Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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