MCID: NNT007
MIFTS: 32

Neonatal Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Neonatal Leukemia

MalaCards integrated aliases for Neonatal Leukemia:

Name: Neonatal Leukemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7756
NCIt 50 C3845
UMLS 73 C0235813

Summaries for Neonatal Leukemia

MalaCards based summary : Neonatal Leukemia is related to acute myeloid leukemia with t(8;16)(p11;p13) translocation and rubinstein-taybi syndrome 1. An important gene associated with Neonatal Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Related phenotypes are cellular and growth/size/body region

Related Diseases for Neonatal Leukemia

Diseases related to Neonatal Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 acute myeloid leukemia with t(8;16)(p11;p13) translocation 10.6 CREBBP KAT6A
2 rubinstein-taybi syndrome 1 10.3 CREBBP EP300
3 human t-cell leukemia virus type 2 10.2 CREBBP EP300
4 myeloproliferative syndrome, transient 10.1 GATA1 PTPN11
5 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 CREBBP FLT3
6 chromosome 16p13.3 deletion syndrome, proximal 10.0 CREBBP EP300 KAT6A
7 leukemia 10.0
8 human t-cell leukemia virus type 1 10.0 CREBBP EP300
9 mn1 9.9 EP300 FLT3
10 bladder squamous cell carcinoma 9.6 CREBBP EP300
11 bone marrow cancer 9.6 FLT3 GATA1 PTPN11
12 down syndrome 9.5
13 hydrops fetalis, nonimmune, and/or atrial septal defect 9.5
14 fetal edema 9.5
15 hydrops fetalis 9.5
16 nut midline carcinoma 9.5 EP300 MYC
17 lymphoblastic leukemia 9.3 AFF1 FLT3 PTPN11
18 myelodysplastic syndrome 9.3 CREBBP FLT3 GATA1 PTPN11
19 myeloid leukemia 9.2 CREBBP FLT3 PTPN11
20 leukemia, acute monocytic 9.2 CREBBP EP300 KAT6A MLLT10 MLLT3
21 precursor t-cell acute lymphoblastic leukemia 9.1 FLT3 MLLT10 MYC
22 wilms tumor 1 9.1 FLT3 GATA1 MYC
23 leukemia, chronic myeloid 9.0 FLT3 GATA1 MYC
24 trehalase deficiency 9.0 CREBBP EP300 KAT6A PTPN11 TCN2
25 acute leukemia 8.8 AFF1 CREBBP FLT3 MLLT10 MLLT3
26 hematologic cancer 7.7 CREBBP EP300 FLT3 MLLT10 MYC PTPN11
27 leukemia, acute myeloid 6.9 AFF1 FLT3 GATA1 KAT6A MLLT10 MLLT3

Graphical network of the top 20 diseases related to Neonatal Leukemia:



Diseases related to Neonatal Leukemia

Symptoms & Phenotypes for Neonatal Leukemia

MGI Mouse Phenotypes related to Neonatal Leukemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 MYC MLLT10 PTPN11 CREBBP GATA1 KAT6A
2 growth/size/body region MP:0005378 10.11 PTPN11 MLLT3 MYC KAT6A EP300 AFF1
3 hematopoietic system MP:0005397 10.09 PTPN11 MLLT3 MYC KAT6A EP300 FLT3
4 immune system MP:0005387 10.06 PTPN11 MLLT3 MYC KAT6A EP300 FLT3
5 embryo MP:0005380 10.04 PTPN11 MLLT3 MYC KAT6A EP300 CREBBP
6 endocrine/exocrine gland MP:0005379 10.02 MYC PTPN11 KAT6A EP300 AFF1 FLT3
7 mortality/aging MP:0010768 9.97 MYC PTPN11 MLLT3 CREBBP GATA1 KAT6A
8 craniofacial MP:0005382 9.91 MYC PTPN11 CREBBP KAT6A EP300
9 liver/biliary system MP:0005370 9.77 MYC KAT6A PTPN11 GATA1 CREBBP
10 neoplasm MP:0002006 9.73 PTPN11 MLLT3 MYC EP300 FLT3 CREBBP
11 no phenotypic analysis MP:0003012 9.55 MYC PTPN11 MLLT3 AFF1 FLT3
12 normal MP:0002873 9.43 MYC PTPN11 GATA1 CREBBP KAT6A EP300
13 skeleton MP:0005390 9.17 MYC PTPN11 MLLT3 KAT6A FLT3 CREBBP

Drugs & Therapeutics for Neonatal Leukemia

Search Clinical Trials , NIH Clinical Center for Neonatal Leukemia

Genetic Tests for Neonatal Leukemia

Anatomical Context for Neonatal Leukemia

Publications for Neonatal Leukemia

Articles related to Neonatal Leukemia:

(show all 12)
# Title Authors Year
1
Clinical and molecular epidemiology of neonatal leukemia in brazil. ( 24991719 )
2014
2
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia. ( 18657848 )
2008
3
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. ( 16333820 )
2006
4
Neonatal leukemia: a nemesis for pediatric oncologists? ( 16206196 )
2006
5
Fetal and neonatal leukemia. ( 12759620 )
2003
6
Congenital and neonatal leukemia. ( 10475541 )
1999
7
Hydrops fetalis and neonatal leukemia in Down syndrome. ( 8718505 )
1996
8
Karyotype evolution in a patient with biphenotypic neonatal leukemia. ( 1394096 )
1992
9
Biphenotypic neonatal leukemia. ( 6886929 )
1983
10
Congenital and neonatal leukemia-- lymphocytic or myelocytic? ( 4531222 )
1974
11
Neonatal leukemia. Detection of herpes virus in the mother and child. ( 5235593 )
1968
12
ON NEONATAL LEUKEMIA. ( 14186700 )
1964

Variations for Neonatal Leukemia

Expression for Neonatal Leukemia

Search GEO for disease gene expression data for Neonatal Leukemia.

Pathways for Neonatal Leukemia

Pathways related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 CREBBP EP300 FLT3 MYC
2 12.64 CREBBP EP300 FLT3 MYC
3
Show member pathways
12.55 CREBBP EP300 FLT3 MYC PTPN11
4
Show member pathways
12.44 CREBBP EP300 MYC PTPN11
5
Show member pathways
12.26 CREBBP EP300 MYC PTPN11
6
Show member pathways
12.24 CREBBP EP300 MYC PTPN11
7 12.18 CREBBP EP300 MYC
8 12.11 CREBBP EP300 MYC
9
Show member pathways
12.03 CREBBP EP300 PTPN11
10
Show member pathways
11.99 CREBBP EP300 PTPN11
11 11.97 CREBBP EP300 GATA1
12
Show member pathways
11.9 CREBBP EP300 MYC PTPN11
13 11.89 CREBBP EP300 MYC
14 11.89 AFF1 FLT3 MLLT3 MYC
15 11.82 CREBBP EP300 MYC
16
Show member pathways
11.71 CREBBP EP300 MYC
17
Show member pathways
11.67 CREBBP MYC PTPN11
18 11.64 CREBBP EP300 MYC
19 11.61 CREBBP EP300 MYC
20 11.54 CREBBP EP300 MYC
21 11.5 CREBBP EP300 MYC
22 11.43 CREBBP EP300 GATA1
23 11.27 CREBBP EP300
24
Show member pathways
11.25 CREBBP EP300
25 11.24 CREBBP EP300
26 11.23 CREBBP EP300 GATA1
27 11.21 CREBBP EP300
28
Show member pathways
11.19 CREBBP EP300
29 11.16 CREBBP EP300
30 11.15 CREBBP EP300 GATA1 MYC
31 11 CREBBP EP300 MYC
32 10.95 CREBBP EP300
33 10.74 CREBBP EP300 KAT6A MYC
34 10.67 CREBBP EP300 FLT3

GO Terms for Neonatal Leukemia

Cellular components related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.65 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
2 protein-containing complex GO:0032991 9.62 FLT3 MLLT10 MYC PTPN11
3 transcription elongation factor complex GO:0008023 9.26 AFF1 MLLT3
4 nucleoplasm GO:0005654 9.23 CREBBP EP300 GATA1 KAT6A MLLT10 MLLT3
5 histone acetyltransferase complex GO:0000123 9.16 CREBBP EP300

Biological processes related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 CREBBP EP300 GATA1 MLLT10 MYC
2 transcription by RNA polymerase II GO:0006366 9.87 EP300 GATA1 MLLT3 MYC
3 heart development GO:0007507 9.75 EP300 GATA1 PTPN11
4 Notch signaling pathway GO:0007219 9.65 CREBBP EP300 MYC
5 positive regulation of transcription, DNA-templated GO:0045893 9.63 CREBBP EP300 GATA1 KAT6A MLLT3 MYC
6 cellular response to UV GO:0034644 9.58 CREBBP EP300 MYC
7 homeostasis of number of cells within a tissue GO:0048873 9.56 GATA1 PTPN11
8 myeloid cell differentiation GO:0030099 9.54 GATA1 KAT6A
9 histone acetylation GO:0016573 9.54 CREBBP EP300 KAT6A
10 positive regulation of transcription of Notch receptor target GO:0007221 9.52 CREBBP EP300
11 megakaryocyte development GO:0035855 9.51 EP300 PTPN11
12 beta-catenin-TCF complex assembly GO:1904837 9.5 CREBBP EP300 MYC
13 dendritic cell differentiation GO:0097028 9.46 FLT3 GATA1
14 N-terminal peptidyl-lysine acetylation GO:0018076 9.26 CREBBP EP300
15 platelet formation GO:0030220 9.13 EP300 GATA1 PTPN11
16 protein acetylation GO:0006473 8.8 CREBBP EP300 KAT6A
17 transcription, DNA-templated GO:0006351 10.04 CREBBP EP300 GATA1 KAT6A MLLT10 MLLT3
18 regulation of transcription, DNA-templated GO:0006355 10.03 AFF1 CREBBP EP300 GATA1 KAT6A MLLT10

Molecular functions related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.89 AFF1 CREBBP GATA1 MLLT10 MYC
2 chromatin binding GO:0003682 9.71 CREBBP EP300 GATA1 MLLT3
3 transcription factor binding GO:0008134 9.67 CREBBP EP300 KAT6A MYC
4 transferase activity, transferring acyl groups GO:0016746 9.61 CREBBP EP300 KAT6A
5 p53 binding GO:0002039 9.5 CREBBP EP300 GATA1
6 activating transcription factor binding GO:0033613 9.48 EP300 MYC
7 RNA polymerase II transcription factor binding GO:0001085 9.43 CREBBP EP300 GATA1
8 histone acetyltransferase activity GO:0004402 9.33 CREBBP EP300 KAT6A
9 peptide N-acetyltransferase activity GO:0034212 8.96 CREBBP EP300
10 acetyltransferase activity GO:0016407 8.8 CREBBP EP300 KAT6A
11 protein binding GO:0005515 10.2 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A

Sources for Neonatal Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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