MCID: NNT007
MIFTS: 28

Neonatal Leukemia

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Neonatal Leukemia

MalaCards integrated aliases for Neonatal Leukemia:

Name: Neonatal Leukemia 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7756
NCIt 49 C3845
UMLS 71 C0235813

Summaries for Neonatal Leukemia

MalaCards based summary : Neonatal Leukemia is related to leukemia and acute leukemia. An important gene associated with Neonatal Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are NF-kappaB Signaling and Signaling events mediated by HDAC Class I. Affiliated tissues include myeloid, monocytes and skin, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Neonatal Leukemia

Graphical network of the top 20 diseases related to Neonatal Leukemia:



Diseases related to Neonatal Leukemia

Symptoms & Phenotypes for Neonatal Leukemia

MGI Mouse Phenotypes related to Neonatal Leukemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.06 AFF1 CREBBP DCLRE1C GATA1 KAT6A MLLT3
2 cardiovascular system MP:0005385 10.02 CREBBP DCLRE1C GATA1 KAT6A MRTFA RAG1
3 hematopoietic system MP:0005397 10.02 AFF1 CREBBP DCLRE1C GATA1 KAT6A MLLT3
4 cellular MP:0005384 10 CREBBP DCLRE1C GATA1 KAT6A MRTFA RAG1
5 endocrine/exocrine gland MP:0005379 9.98 AFF1 CREBBP DCLRE1C KAT6A MRTFA RAG1
6 immune system MP:0005387 9.97 AFF1 CREBBP DCLRE1C GATA1 KAT6A MLLT3
7 integument MP:0010771 9.73 CREBBP GATA1 KAT6A MRTFA RAG1 TTC7A
8 mortality/aging MP:0010768 9.61 AFF1 CREBBP GATA1 KAT6A MLLT3 MRTFA
9 liver/biliary system MP:0005370 9.55 CREBBP GATA1 KAT6A RAG1 TTC7A
10 neoplasm MP:0002006 9.02 CREBBP MLLT3 RAG1 RBM15 TTC7A

Drugs & Therapeutics for Neonatal Leukemia

Search Clinical Trials , NIH Clinical Center for Neonatal Leukemia

Genetic Tests for Neonatal Leukemia

Anatomical Context for Neonatal Leukemia

MalaCards organs/tissues related to Neonatal Leukemia:

40
Myeloid, Monocytes, Skin, T Cells, B Cells

Publications for Neonatal Leukemia

Articles related to Neonatal Leukemia:

(show all 31)
# Title Authors PMID Year
1
Dermoscopic findings in neonatal leukemia cutis. 61
31468564 2019
2
Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus. 61
27510896 2016
3
iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation. 61
27152438 2016
4
Evolution of myeloid leukemia in children with Down syndrome. 61
26910243 2016
5
Clinical and molecular epidemiology of neonatal leukemia in Brazil. 61
24991719 2015
6
Transient leukemia in a newborn without Down syndrome: case report and review of the literature. 61
24253371 2014
7
Update on transcobalamin deficiency: clinical presentation, treatment and outcome. 61
24305960 2014
8
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia. 61
18657848 2008
9
Fetal leukemia with umbilical artery embolism and circulatory failure. 61
17267881 2007
10
Neonatal leukemia: a nemesis for pediatric oncologists? 61
16206196 2006
11
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. 61
16333820 2006
12
[Transient neonatal myeloproliferative disorder in the absence of Down syndrome]. 61
15574256 2004
13
Fetal and neonatal leukemia. 61
12759620 2003
14
Congenital and neonatal leukemia. 61
10475541 1999
15
[Neonatal monoblastic leukemia revealed by transitory specific skin lesions]. 61
10352833 1999
16
Congenital leukemia cutis: an unusual manifestation of a rare disease. 61
9393480 1997
17
Cytogenetic, cytomorphologic, and immunologic analysis in 55 children with acute lymphoblastic leukemia. 61
8630981 1996
18
Hydrops fetalis and neonatal leukemia in Down syndrome. 61
8718505 1996
19
Transient leukemia followed by megakaryoblastic leukemia in a child with mosaic Down syndrome. 61
8580807 1995
20
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. 61
7846532 1995
21
Karyotype evolution in a patient with biphenotypic neonatal leukemia. 61
1394096 1992
22
Biphenotypic neonatal leukemia. 61
6886929 1983
23
[Acute leukemia in infants]. 61
299303 1979
24
Neonatal oncology. 61
197475 1977
25
[Neonatal leukemia. Report of seven cases (author's transl)]. 61
1066063 1976
26
Congenital and neonatal leukemia-- lymphocytic or myelocytic? 61
4531222 1974
27
[A case of acute neonatal leukemia]. 61
5436279 1970
28
[Connatal and neonatal leukemia. Review of world literature]. 61
4937006 1970
29
Neonatal leukemia. Detection of herpes virus in the mother and child. 61
5235593 1968
30
[Neonatal leukemia]. 61
5955052 1966
31
ON NEONATAL LEUKEMIA. 61
14186700 1964

Variations for Neonatal Leukemia

Expression for Neonatal Leukemia

Search GEO for disease gene expression data for Neonatal Leukemia.

Pathways for Neonatal Leukemia

Pathways related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 RAG1 MRTFA GATA1 DCLRE1C
2 11.14 GATA1 CREBBP
3 11.08 KAT6A CREBBP
4 10.84 GATA1 CREBBP
5 10.54 RAG1 DCLRE1C

GO Terms for Neonatal Leukemia

Cellular components related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.91 RBM15 RAG1 MRTFA MLLT3 KAT6A GATA1
2 nucleoplasm GO:0005654 9.23 RBM15 RAG1 MRTFA MLLT3 KAT6A GATA1
3 histone acetyltransferase complex GO:0000123 9.16 KAT6A CREBBP
4 transcription elongation factor complex GO:0008023 8.96 MLLT3 AFF1

Biological processes related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.8 MLLT3 KAT6A GATA1 CREBBP AFF1
2 positive regulation of transcription, DNA-templated GO:0045893 9.62 MLLT3 KAT6A GATA1 CREBBP
3 histone acetylation GO:0016573 9.37 KAT6A CREBBP
4 myeloid cell differentiation GO:0030099 9.26 KAT6A GATA1
5 positive regulation of transcription of Notch receptor target GO:0007221 9.16 RBM15 CREBBP
6 protein acetylation GO:0006473 8.96 KAT6A CREBBP
7 V(D)J recombination GO:0033151 8.62 RAG1 DCLRE1C

Molecular functions related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.71 RAG1 KAT6A GATA1 CREBBP
2 p53 binding GO:0002039 9.43 GATA1 CREBBP
3 damaged DNA binding GO:0003684 9.37 DCLRE1C CREBBP
4 transcription coactivator activity GO:0003713 9.33 MRTFA KAT6A CREBBP
5 RNA polymerase II transcription factor binding GO:0001085 9.32 GATA1 CREBBP
6 histone acetyltransferase activity GO:0004402 9.26 KAT6A CREBBP
7 acetyltransferase activity GO:0016407 8.96 KAT6A CREBBP
8 histone binding GO:0042393 8.8 RAG1 MLLT3 KAT6A

Sources for Neonatal Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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