MCID: NNT007
MIFTS: 29

Neonatal Leukemia

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Neonatal Leukemia

MalaCards integrated aliases for Neonatal Leukemia:

Name: Neonatal Leukemia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:7756
NCIt 51 C3845
UMLS 74 C0235813

Summaries for Neonatal Leukemia

MalaCards based summary : Neonatal Leukemia is related to leukemia and chromosome 16p13.3 deletion syndrome, proximal. An important gene associated with Neonatal Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are Endometrial cancer and ErbB signaling pathway. Related phenotypes are cellular and growth/size/body region

Related Diseases for Neonatal Leukemia

Graphical network of the top 20 diseases related to Neonatal Leukemia:



Diseases related to Neonatal Leukemia

Symptoms & Phenotypes for Neonatal Leukemia

MGI Mouse Phenotypes related to Neonatal Leukemia:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CREBBP FLT3 GATA1 KAT6A MLLT10 MYC
2 growth/size/body region MP:0005378 10.03 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
3 hematopoietic system MP:0005397 10.01 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
4 immune system MP:0005387 9.97 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
5 embryo MP:0005380 9.95 CREBBP GATA1 KAT6A MLLT3 MYC PTPN11
6 endocrine/exocrine gland MP:0005379 9.93 AFF1 CREBBP FLT3 KAT6A MYC PTPN11
7 mortality/aging MP:0010768 9.86 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
8 liver/biliary system MP:0005370 9.72 CREBBP GATA1 KAT6A MYC PTPN11
9 neoplasm MP:0002006 9.55 CREBBP FLT3 MLLT3 MYC PTPN11
10 no phenotypic analysis MP:0003012 9.35 AFF1 FLT3 MLLT3 MYC PTPN11
11 skeleton MP:0005390 9.17 CREBBP FLT3 GATA1 KAT6A MLLT3 MYC

Drugs & Therapeutics for Neonatal Leukemia

Search Clinical Trials , NIH Clinical Center for Neonatal Leukemia

Genetic Tests for Neonatal Leukemia

Anatomical Context for Neonatal Leukemia

Publications for Neonatal Leukemia

Articles related to Neonatal Leukemia:

(show all 12)
# Title Authors Year
1
Clinical and molecular epidemiology of neonatal leukemia in brazil. ( 24991719 )
2014
2
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia. ( 18657848 )
2008
3
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. ( 16333820 )
2006
4
Neonatal leukemia: a nemesis for pediatric oncologists? ( 16206196 )
2006
5
Fetal and neonatal leukemia. ( 12759620 )
2003
6
Congenital and neonatal leukemia. ( 10475541 )
1999
7
Hydrops fetalis and neonatal leukemia in Down syndrome. ( 8718505 )
1996
8
Karyotype evolution in a patient with biphenotypic neonatal leukemia. ( 1394096 )
1992
9
Biphenotypic neonatal leukemia. ( 6886929 )
1983
10
Congenital and neonatal leukemia-- lymphocytic or myelocytic? ( 4531222 )
1974
11
Neonatal leukemia. Detection of herpes virus in the mother and child. ( 5235593 )
1968
12
ON NEONATAL LEUKEMIA. ( 14186700 )
1964

Variations for Neonatal Leukemia

Expression for Neonatal Leukemia

Search GEO for disease gene expression data for Neonatal Leukemia.

Pathways for Neonatal Leukemia

Pathways related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 CREBBP FLT3 MYC PTPN11
2
Show member pathways
12.16 CREBBP MYC PTPN11
3
Show member pathways
12.1 CREBBP MYC PTPN11
4
Show member pathways
12.05 CREBBP MYC PTPN11
5 11.27 MYC PTPN11
6 11.23 MYC PTPN11
7 11.22 CREBBP GATA1 MYC
8 11.19 AFF1 FLT3 MLLT3 MYC
9 11.18 CREBBP GATA1
10 11.13 MYC PTPN11
11 11.07 CREBBP MYC
12 10.95 CREBBP KAT6A MYC
13 10.94 CREBBP MYC
14 10.6 CREBBP FLT3

GO Terms for Neonatal Leukemia

Cellular components related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.62 FLT3 MLLT10 MYC PTPN11
2 nuclear chromatin GO:0000790 9.54 CREBBP KAT6A MYC
3 nucleoplasm GO:0005654 9.5 CREBBP GATA1 KAT6A MLLT10 MLLT3 MYC
4 nucleus GO:0005634 9.28 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT10
5 histone acetyltransferase complex GO:0000123 9.26 CREBBP KAT6A
6 transcription elongation factor complex GO:0008023 9.16 AFF1 MLLT3

Biological processes related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.77 CREBBP GATA1 KAT6A MLLT10 MYC
2 cytokine-mediated signaling pathway GO:0019221 9.67 FLT3 MYC PTPN11
3 cellular response to cytokine stimulus GO:0071345 9.55 FLT3 PTPN11
4 histone acetylation GO:0016573 9.54 CREBBP KAT6A
5 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.52 FLT3 PTPN11
6 cellular response to UV GO:0034644 9.51 CREBBP MYC
7 homeostasis of number of cells within a tissue GO:0048873 9.46 GATA1 PTPN11
8 beta-catenin-TCF complex assembly GO:1904837 9.43 CREBBP MYC
9 regulation of transcription, DNA-templated GO:0006355 9.43 AFF1 CREBBP GATA1 KAT6A MLLT3 MYC
10 myeloid cell differentiation GO:0030099 9.4 GATA1 KAT6A
11 platelet formation GO:0030220 9.32 GATA1 PTPN11
12 protein acetylation GO:0006473 9.26 CREBBP KAT6A
13 cellular response to epidermal growth factor stimulus GO:0071364 9.18 PTPN11
14 dendritic cell differentiation GO:0097028 9.16 FLT3 GATA1
15 positive regulation of transcription, DNA-templated GO:0045893 9.02 CREBBP GATA1 KAT6A MLLT3 MYC

Molecular functions related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.46 CREBBP GATA1 MLLT10 MLLT3
2 histone acetyltransferase activity GO:0004402 9.43 CREBBP KAT6A
3 RNA polymerase II transcription factor binding GO:0001085 9.4 CREBBP GATA1
4 1-phosphatidylinositol-3-kinase activity GO:0016303 9.37 FLT3 PTPN11
5 acetyltransferase activity GO:0016407 9.26 CREBBP KAT6A
6 histone binding GO:0042393 9.13 KAT6A MLLT10 MLLT3
7 DNA-binding transcription factor activity GO:0003700 8.92 AFF1 GATA1 MLLT10 MYC
8 protein binding GO:0005515 10.02 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT10

Sources for Neonatal Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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