MCID: NNT007
MIFTS: 30

Neonatal Leukemia

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Neonatal Leukemia

MalaCards integrated aliases for Neonatal Leukemia:

Name: Neonatal Leukemia 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:7756
NCIt 50 C3845
UMLS 72 C0235813

Summaries for Neonatal Leukemia

MalaCards based summary : Neonatal Leukemia is related to leukemia and myeloid leukemia. An important gene associated with Neonatal Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are Endometrial cancer and ErbB signaling pathway. Affiliated tissues include myeloid and skin, and related phenotypes are cellular and growth/size/body region

Related Diseases for Neonatal Leukemia

Graphical network of the top 20 diseases related to Neonatal Leukemia:



Diseases related to Neonatal Leukemia

Symptoms & Phenotypes for Neonatal Leukemia

MGI Mouse Phenotypes related to Neonatal Leukemia:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CREBBP FLT3 GATA1 KAT6A MLLT10 MYC
2 growth/size/body region MP:0005378 10.03 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
3 hematopoietic system MP:0005397 10.01 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
4 immune system MP:0005387 9.97 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
5 embryo MP:0005380 9.95 CREBBP GATA1 KAT6A MLLT3 MYC PTPN11
6 endocrine/exocrine gland MP:0005379 9.93 AFF1 CREBBP FLT3 KAT6A MYC PTPN11
7 mortality/aging MP:0010768 9.86 AFF1 CREBBP FLT3 GATA1 KAT6A MLLT3
8 liver/biliary system MP:0005370 9.72 CREBBP GATA1 KAT6A MYC PTPN11
9 neoplasm MP:0002006 9.55 CREBBP FLT3 MLLT3 MYC PTPN11
10 no phenotypic analysis MP:0003012 9.35 AFF1 FLT3 MLLT3 MYC PTPN11
11 skeleton MP:0005390 9.17 CREBBP FLT3 GATA1 KAT6A MLLT3 MYC

Drugs & Therapeutics for Neonatal Leukemia

Search Clinical Trials , NIH Clinical Center for Neonatal Leukemia

Genetic Tests for Neonatal Leukemia

Anatomical Context for Neonatal Leukemia

MalaCards organs/tissues related to Neonatal Leukemia:

41
Myeloid, Skin

Publications for Neonatal Leukemia

Articles related to Neonatal Leukemia:

(show all 30)
# Title Authors PMID Year
1
Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus. 38
27510896 2016
2
iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation. 38
27152438 2016
3
Evolution of myeloid leukemia in children with Down syndrome. 38
26910243 2016
4
Clinical and molecular epidemiology of neonatal leukemia in Brazil. 38
24991719 2015
5
Transient leukemia in a newborn without Down syndrome: case report and review of the literature. 38
24253371 2014
6
Update on transcobalamin deficiency: clinical presentation, treatment and outcome. 38
24305960 2014
7
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia. 38
18657848 2008
8
Fetal leukemia with umbilical artery embolism and circulatory failure. 38
17267881 2007
9
Neonatal leukemia: a nemesis for pediatric oncologists? 38
16206196 2006
10
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. 38
16333820 2006
11
[Transient neonatal myeloproliferative disorder in the absence of Down syndrome]. 38
15574256 2004
12
Fetal and neonatal leukemia. 38
12759620 2003
13
Congenital and neonatal leukemia. 38
10475541 1999
14
[Neonatal monoblastic leukemia revealed by transitory specific skin lesions]. 38
10352833 1999
15
Congenital leukemia cutis: an unusual manifestation of a rare disease. 38
9393480 1997
16
Cytogenetic, cytomorphologic, and immunologic analysis in 55 children with acute lymphoblastic leukemia. 38
8630981 1996
17
Hydrops fetalis and neonatal leukemia in Down syndrome. 38
8718505 1996
18
Transient leukemia followed by megakaryoblastic leukemia in a child with mosaic Down syndrome. 38
8580807 1995
19
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. 38
7846532 1995
20
Karyotype evolution in a patient with biphenotypic neonatal leukemia. 38
1394096 1992
21
Biphenotypic neonatal leukemia. 38
6886929 1983
22
[Acute leukemia in infants]. 38
299303 1979
23
Neonatal oncology. 38
197475 1977
24
[Neonatal leukemia. Report of seven cases (author's transl)]. 38
1066063 1976
25
Congenital and neonatal leukemia-- lymphocytic or myelocytic? 38
4531222 1974
26
[A case of acute neonatal leukemia]. 38
5436279 1970
27
[Connatal and neonatal leukemia. Review of world literature]. 38
4937006 1970
28
Neonatal leukemia. Detection of herpes virus in the mother and child. 38
5235593 1968
29
[Neonatal leukemia]. 38
5955052 1966
30
ON NEONATAL LEUKEMIA. 38
14186700 1964

Variations for Neonatal Leukemia

Expression for Neonatal Leukemia

Search GEO for disease gene expression data for Neonatal Leukemia.

Pathways for Neonatal Leukemia

Pathways related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 PTPN11 MYC FLT3 CREBBP
2
Show member pathways
12.19 PTPN11 MYC CREBBP
3
Show member pathways
12.12 PTPN11 MYC CREBBP
4
Show member pathways
12.07 PTPN11 MYC CREBBP
5
Show member pathways
11.37 PTPN11 MYC CREBBP
6 11.28 PTPN11 MYC
7 11.24 PTPN11 MYC
8 11.22 MYC GATA1 CREBBP
9 11.19 GATA1 CREBBP
10 11.19 MYC MLLT3 FLT3 AFF1
11 11.15 PTPN11 MYC
12 11.1 MYC CREBBP
13 10.97 MYC CREBBP
14 10.95 MYC KAT6A CREBBP
15 10.66 FLT3 CREBBP

GO Terms for Neonatal Leukemia

Cellular components related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.62 PTPN11 MYC MLLT10 FLT3
2 nuclear chromatin GO:0000790 9.54 MYC KAT6A CREBBP
3 nucleoplasm GO:0005654 9.5 PTPN11 MYC MLLT3 MLLT10 KAT6A GATA1
4 nucleus GO:0005634 9.28 PTPN11 MYC MLLT3 MLLT10 KAT6A GATA1
5 histone acetyltransferase complex GO:0000123 9.26 KAT6A CREBBP
6 transcription elongation factor complex GO:0008023 9.16 MLLT3 AFF1

Biological processes related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.77 MYC MLLT10 KAT6A GATA1 CREBBP
2 cytokine-mediated signaling pathway GO:0019221 9.67 PTPN11 MYC FLT3
3 histone acetylation GO:0016573 9.54 KAT6A CREBBP
4 cellular response to cytokine stimulus GO:0071345 9.52 PTPN11 FLT3
5 cellular response to UV GO:0034644 9.51 MYC CREBBP
6 cellular response to epidermal growth factor stimulus GO:0071364 9.48 PTPN11 MYC
7 homeostasis of number of cells within a tissue GO:0048873 9.46 PTPN11 GATA1
8 beta-catenin-TCF complex assembly GO:1904837 9.43 MYC CREBBP
9 regulation of transcription, DNA-templated GO:0006355 9.43 MYC MLLT3 KAT6A GATA1 CREBBP AFF1
10 myeloid cell differentiation GO:0030099 9.4 KAT6A GATA1
11 platelet formation GO:0030220 9.32 PTPN11 GATA1
12 protein acetylation GO:0006473 9.26 KAT6A CREBBP
13 dendritic cell differentiation GO:0097028 9.16 GATA1 FLT3
14 positive regulation of transcription, DNA-templated GO:0045893 9.02 MYC MLLT3 KAT6A GATA1 CREBBP

Molecular functions related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.46 MLLT3 MLLT10 GATA1 CREBBP
2 histone acetyltransferase activity GO:0004402 9.4 KAT6A CREBBP
3 RNA polymerase II transcription factor binding GO:0001085 9.37 GATA1 CREBBP
4 acetyltransferase activity GO:0016407 9.26 KAT6A CREBBP
5 histone binding GO:0042393 9.13 MLLT3 MLLT10 KAT6A
6 DNA-binding transcription factor activity GO:0003700 8.92 MYC MLLT10 GATA1 AFF1
7 protein binding GO:0005515 10.02 TCN2 PTPN11 MYC MLLT3 MLLT10 KAT6A

Sources for Neonatal Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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