MCID: NNT007
MIFTS: 34

Neonatal Leukemia

Categories: Blood diseases, Cancer diseases

Aliases & Classifications for Neonatal Leukemia

MalaCards integrated aliases for Neonatal Leukemia:

Name: Neonatal Leukemia 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7756
NCIt 50 C3845
UMLS 73 C0235813

Summaries for Neonatal Leukemia

MalaCards based summary : Neonatal Leukemia is related to leukemia and acute myeloid leukemia with t(8;16)(p11;p13) translocation. An important gene associated with Neonatal Leukemia is KAT6A (Lysine Acetyltransferase 6A), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include bone, t cells and myeloid, and related phenotypes are cellular and growth/size/body region

Related Diseases for Neonatal Leukemia

Graphical network of the top 20 diseases related to Neonatal Leukemia:



Diseases related to Neonatal Leukemia

Symptoms & Phenotypes for Neonatal Leukemia

MGI Mouse Phenotypes related to Neonatal Leukemia:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.13 CREBBP EP300 FLT3 GATA1 KAT6A MLLT10
2 growth/size/body region MP:0005378 10.11 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
3 hematopoietic system MP:0005397 10.09 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
4 immune system MP:0005387 10.06 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
5 embryo MP:0005380 10.04 CREBBP EP300 GATA1 KAT6A MLLT3 MYC
6 endocrine/exocrine gland MP:0005379 10.02 AFF1 CREBBP EP300 FLT3 KAT6A MYC
7 mortality/aging MP:0010768 9.97 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
8 craniofacial MP:0005382 9.91 CREBBP EP300 KAT6A MYC PTPN11
9 liver/biliary system MP:0005370 9.77 CREBBP GATA1 KAT6A MYC PTPN11
10 neoplasm MP:0002006 9.73 CREBBP EP300 FLT3 MLLT3 MYC PTPN11
11 no phenotypic analysis MP:0003012 9.55 AFF1 FLT3 MLLT3 MYC PTPN11
12 normal MP:0002873 9.43 CREBBP EP300 GATA1 KAT6A MYC PTPN11
13 skeleton MP:0005390 9.17 CREBBP FLT3 GATA1 KAT6A MLLT3 MYC

Drugs & Therapeutics for Neonatal Leukemia

Search Clinical Trials , NIH Clinical Center for Neonatal Leukemia

Genetic Tests for Neonatal Leukemia

Anatomical Context for Neonatal Leukemia

MalaCards organs/tissues related to Neonatal Leukemia:

41
Bone, T Cells, Myeloid, Bone Marrow, Monocytes

Publications for Neonatal Leukemia

Articles related to Neonatal Leukemia:

(show all 12)
# Title Authors Year
1
Clinical and molecular epidemiology of neonatal leukemia in brazil. ( 24991719 )
2014
2
t(8;16)(p11;p13) predisposes to a transient but potentially recurring neonatal leukemia. ( 18657848 )
2008
3
Features and outcome of neonatal leukemia in Japan: experience of the Japan infant leukemia study group. ( 16333820 )
2006
4
Neonatal leukemia: a nemesis for pediatric oncologists? ( 16206196 )
2006
5
Fetal and neonatal leukemia. ( 12759620 )
2003
6
Congenital and neonatal leukemia. ( 10475541 )
1999
7
Hydrops fetalis and neonatal leukemia in Down syndrome. ( 8718505 )
1996
8
Karyotype evolution in a patient with biphenotypic neonatal leukemia. ( 1394096 )
1992
9
Biphenotypic neonatal leukemia. ( 6886929 )
1983
10
Congenital and neonatal leukemia-- lymphocytic or myelocytic? ( 4531222 )
1974
11
Neonatal leukemia. Detection of herpes virus in the mother and child. ( 5235593 )
1968
12
ON NEONATAL LEUKEMIA. ( 14186700 )
1964

Variations for Neonatal Leukemia

Expression for Neonatal Leukemia

Search GEO for disease gene expression data for Neonatal Leukemia.

Pathways for Neonatal Leukemia

Pathways related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1 12.64 CREBBP EP300 FLT3 MYC
2
Show member pathways
12.55 CREBBP EP300 FLT3 MYC PTPN11
3
Show member pathways
12.26 CREBBP EP300 MYC PTPN11
4
Show member pathways
12.23 CREBBP EP300 MYC PTPN11
5
Show member pathways
12.21 EP300 MYC PTPN11
6
Show member pathways
12.2 CREBBP EP300 MYC PTPN11
7 12.17 CREBBP EP300 MYC
8
Show member pathways
12.03 CREBBP EP300 PTPN11
9
Show member pathways
11.99 CREBBP EP300 PTPN11
10 11.97 CREBBP EP300 GATA1
11 11.89 CREBBP EP300 MYC
12
Show member pathways
11.89 CREBBP EP300 MYC PTPN11
13 11.89 AFF1 FLT3 MLLT3 MYC
14 11.82 CREBBP EP300 MYC
15
Show member pathways
11.71 CREBBP EP300 MYC
16
Show member pathways
11.67 CREBBP MYC PTPN11
17 11.65 CREBBP EP300 MYC
18 11.61 CREBBP EP300 MYC
19 11.56 CREBBP EP300 MYC
20 11.5 CREBBP EP300 MYC
21 11.43 CREBBP EP300 GATA1
22 11.27 CREBBP EP300
23
Show member pathways
11.24 CREBBP EP300
24 11.24 CREBBP EP300
25 11.23 CREBBP EP300 GATA1
26 11.21 CREBBP EP300
27
Show member pathways
11.19 CREBBP EP300
28 11.16 CREBBP EP300
29 11.15 CREBBP EP300 GATA1 MYC
30 11 CREBBP EP300 MYC
31 10.95 CREBBP EP300
32 10.74 CREBBP EP300 KAT6A MYC
33 10.67 CREBBP EP300 FLT3

GO Terms for Neonatal Leukemia

Cellular components related to Neonatal Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.96 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A
2 nucleoplasm GO:0005654 9.76 CREBBP EP300 GATA1 KAT6A MLLT10 MLLT3
3 nuclear chromatin GO:0000790 9.54 CREBBP KAT6A MYC
4 protein-containing complex GO:0032991 9.35 EP300 FLT3 MLLT10 MYC PTPN11
5 transcription elongation factor complex GO:0008023 9.32 AFF1 MLLT3
6 histone acetyltransferase complex GO:0000123 8.8 CREBBP EP300 KAT6A

Biological processes related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.93 CREBBP EP300 GATA1 KAT6A MLLT10 MYC
2 regulation of transcription, DNA-templated GO:0006355 9.91 AFF1 CREBBP EP300 GATA1 KAT6A MLLT3
3 transcription by RNA polymerase II GO:0006366 9.88 EP300 GATA1 MLLT3 MYC
4 heart development GO:0007507 9.77 EP300 GATA1 PTPN11
5 Notch signaling pathway GO:0007219 9.67 CREBBP EP300 MYC
6 positive regulation of transcription, DNA-templated GO:0045893 9.63 CREBBP EP300 GATA1 KAT6A MLLT3 MYC
7 histone acetylation GO:0016573 9.61 CREBBP EP300 KAT6A
8 positive regulation of type I interferon production GO:0032481 9.59 CREBBP EP300
9 histone H4 acetylation GO:0043967 9.58 EP300 KAT6A
10 cellular response to UV GO:0034644 9.58 CREBBP EP300 MYC
11 homeostasis of number of cells within a tissue GO:0048873 9.57 GATA1 PTPN11
12 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 9.56 CREBBP EP300
13 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 9.55 CREBBP EP300
14 myeloid cell differentiation GO:0030099 9.54 GATA1 KAT6A
15 positive regulation of transcription of Notch receptor target GO:0007221 9.52 CREBBP EP300
16 megakaryocyte development GO:0035855 9.51 EP300 PTPN11
17 dendritic cell differentiation GO:0097028 9.48 FLT3 GATA1
18 beta-catenin-TCF complex assembly GO:1904837 9.43 CREBBP EP300 MYC
19 N-terminal peptidyl-lysine acetylation GO:0018076 9.32 CREBBP EP300
20 platelet formation GO:0030220 9.13 EP300 GATA1 PTPN11
21 protein acetylation GO:0006473 8.8 CREBBP EP300 KAT6A

Molecular functions related to Neonatal Leukemia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.88 AFF1 CREBBP GATA1 MLLT10 MYC
2 transcription factor binding GO:0008134 9.71 CREBBP EP300 KAT6A MYC
3 transferase activity, transferring acyl groups GO:0016746 9.67 CREBBP EP300 KAT6A
4 histone binding GO:0042393 9.61 KAT6A MLLT10 MLLT3
5 chromatin binding GO:0003682 9.55 CREBBP EP300 GATA1 MLLT10 MLLT3
6 p53 binding GO:0002039 9.54 CREBBP EP300 GATA1
7 activating transcription factor binding GO:0033613 9.51 EP300 MYC
8 histone acetyltransferase activity GO:0004402 9.5 CREBBP EP300 KAT6A
9 RNA polymerase II transcription factor binding GO:0001085 9.43 CREBBP EP300 GATA1
10 peptide N-acetyltransferase activity GO:0034212 8.96 CREBBP EP300
11 acetyltransferase activity GO:0016407 8.8 CREBBP EP300 KAT6A
12 protein binding GO:0005515 10.2 AFF1 CREBBP EP300 FLT3 GATA1 KAT6A

Sources for Neonatal Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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