MCID: NNT042
MIFTS: 37

Neonatal Lupus Erythematosus

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Neonatal Lupus Erythematosus

MalaCards integrated aliases for Neonatal Lupus Erythematosus:

Name: Neonatal Lupus Erythematosus 59
Neonatal Systemic Lupus Erythematosus 73

Characteristics:

Orphanet epidemiological data:

59
neonatal lupus erythematosus
Prevalence: 1-9/100000 (United States); Age of onset: Neonatal;

Classifications:



External Ids:

Orphanet 59 ORPHA398124
UMLS via Orphanet 74 C0409979
ICD10 via Orphanet 34 M32.8
UMLS 73 C0409979

Summaries for Neonatal Lupus Erythematosus

MalaCards based summary : Neonatal Lupus Erythematosus, also known as neonatal systemic lupus erythematosus, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Neonatal Lupus Erythematosus is RAB11FIP5 (RAB11 Family Interacting Protein 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response Antigen presentation by MHC class II. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and skin, and related phenotype is Increased cell size.

Wikipedia : 76 Neonatal lupus erythematosus is the occurrence of systemic lupus erythematosus (SLE) symptoms in an... more...

Related Diseases for Neonatal Lupus Erythematosus

Graphical network of the top 20 diseases related to Neonatal Lupus Erythematosus:



Diseases related to Neonatal Lupus Erythematosus

Symptoms & Phenotypes for Neonatal Lupus Erythematosus

GenomeRNAi Phenotypes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell size GR00098-A-4 8.62 HLA-DQA1 SPTAN1

Drugs & Therapeutics for Neonatal Lupus Erythematosus

Drugs for Neonatal Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2, Phase 3
2 gamma-Globulins Phase 2, Phase 3
3 Antibodies Phase 2, Phase 3,Not Applicable
4 Immunoglobulins Phase 2, Phase 3,Not Applicable
5 Immunoglobulins, Intravenous Phase 2, Phase 3
6 Autoantibodies Phase 2, Phase 3
7
Hydroxychloroquine Approved Phase 2 118-42-3 3652
8 Anti-Infective Agents Phase 2
9 Antiparasitic Agents Phase 2
10 Antiprotozoal Agents Phase 2
11 Antimalarials Phase 2
12 Antirheumatic Agents Phase 2
13
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
14 Dexamethasone acetate Not Applicable 1177-87-3
15 glucocorticoids Not Applicable
16
protease inhibitors Not Applicable
17 Gastrointestinal Agents Not Applicable
18 HIV Protease Inhibitors Not Applicable
19 Hormone Antagonists Not Applicable
20 Hormones Not Applicable
21 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
22 Peripheral Nervous System Agents Not Applicable
23 Antiemetics Not Applicable
24 Anti-Inflammatory Agents Not Applicable
25 BB 1101 Not Applicable
26 Autonomic Agents Not Applicable
27 Antineoplastic Agents, Hormonal Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventive IVIG Therapy for Congenital Heart Block Completed NCT00460928 Phase 2, Phase 3 intravenous immune globulin (IVIG)
2 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
3 Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus Completed NCT00007358 Not Applicable Dexamethasone or other corticosteroid
4 The Research Registry for Neonatal Lupus Recruiting NCT00074373
5 Prospective Maternal Surveillance of SSA (Sjögren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Heart Rate Monitor Recruiting NCT02920346

Search NIH Clinical Center for Neonatal Lupus Erythematosus

Genetic Tests for Neonatal Lupus Erythematosus

Anatomical Context for Neonatal Lupus Erythematosus

MalaCards organs/tissues related to Neonatal Lupus Erythematosus:

41
Heart, Bone, Skin, Neutrophil, B Cells

Publications for Neonatal Lupus Erythematosus

Articles related to Neonatal Lupus Erythematosus:

(show top 50) (show all 60)
# Title Authors Year
1
Cutaneous Neonatal Lupus Erythematosus: A Case Report. ( 29686954 )
2018
2
Neonatal lupus erythematosus. ( 28603203 )
2017
3
Discordant disease expression of neonatal lupus erythematosus in twins. ( 28585599 )
2017
4
Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review. ( 29116459 )
2017
5
A case of neonatal lupus erythematosus in a very low birth weight infant that suffered intraventricular hemorrhage at birth. ( 26872497 )
2016
6
Extensive aortic aneurysm associated with neonatal lupus erythematosus. ( 27212867 )
2016
7
Neonatal lupus erythematosus with congenital heart block in twins. ( 28051234 )
2016
8
Neonatal lupus erythematosus: a cutaneous cases based update. ( 26743447 )
2016
9
Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings. ( 27922246 )
2016
10
Unusual Skin Manifestations in Neonatal Lupus Erythematosus. ( 27276848 )
2015
11
Cytokine profile in two siblings with neonatal lupus erythematosus. ( 26711923 )
2015
12
Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus. ( 26269318 )
2015
13
Neonatal lupus erythematosus: a review of 123 cases in China. ( 26171790 )
2015
14
Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review. ( 25755869 )
2014
15
Neonatal lupus erythematosus: the use of telephone images in diagnosis. ( 24888545 )
2014
16
A 6-week-old boy with annular skin lesions. Neonatal lupus erythematosus. ( 24450316 )
2014
17
Marked histiocytic infiltration in neonatal lupus erythematosus. ( 24471465 )
2014
18
CNS vasculitis and stroke in neonatal lupus erythematosus: a case report and review of literature. ( 24508360 )
2014
19
A case of neonatal lupus erythematosus with a typical malar rash. ( 24407234 )
2014
20
Targetoid lesions and neutrophilic dermatosis: an initial clinical and histological presentation of neonatal lupus erythematosus. ( 23331164 )
2014
21
Neonatal lupus erythematosus: a 20-year retrospective study. ( 25391176 )
2014
22
Neonatal lupus erythematosus complicated by improved congenital complete heart block. ( 23910804 )
2013
23
Neonatal Lupus Erythematosus Presenting as Atypical Targetoid-like Lesions Involving Genitals and Soles of Feet Following Brief Sun Exposure. ( 23710267 )
2013
24
Neonatal lupus erythematosus mimicking extensive capillary malformation. ( 23819452 )
2013
25
Neonatal lupus erythematosus and its clinical variability. ( 22606966 )
2012
26
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 26344845 )
2012
27
Cutaneous neonatal lupus erythematosus. ( 23075661 )
2012
28
Facial telangiectasia: an unusual manifestation of neonatal lupus erythematosus. ( 22170760 )
2012
29
Neonatal lupus erythematosus. ( 22973504 )
2012
30
Picture of the month--a case of neonatal lupus erythematosus and associated hepatitis. ( 22393185 )
2012
31
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 22276811 )
2012
32
Congenital and neonatal lupus erythematosus: two case reports. ( 22892781 )
2012
33
Comment on: Early cholestasis in neonatal lupus erythematosus. Ann Saudi Med 2011; 31: 80-2. ( 21623063 )
2011
34
Early cholestasis in neonatal lupus erythematosus. ( 20864789 )
2011
35
Neonatal lupus erythematosus in identical twins, showing transient bullous lesions. ( 21793882 )
2011
36
Neonatal lupus erythematosus: a report of four cases. ( 21603821 )
2011
37
Neonatal lupus erythematosus and cutis marmorata telangiectatica congenita-like lesions. ( 20064177 )
2009
38
Congenital heart block in neonatal lupus erythematosus. ( 19274557 )
2009
39
A case of neonatal lupus erythematosus presenting delayed dilated cardiomyopathy with circulating autoantibody to annexin A6. ( 17592206 )
2007
40
[Neonatal lupus erythematosus]. ( 17868532 )
2007
41
Late neonatal lupus erythematosus onset in a child born of a mother with primary SjAPgren's syndrome. ( 15479901 )
2004
42
Neonatal lupus erythematosus associated with maternal mixed connective tissue disease. ( 12709154 )
2003
43
Neonatal lupus erythematosus with recurrent pancytopenia: a case report. ( 12542254 )
2002
44
The health of mothers of children with cutaneous neonatal lupus erythematosus differs from that of mothers of children with congenital heart block. ( 10924646 )
2000
45
Neonatal lupus erythematosus: maternal IgG antibodies bind to a recombinant NH2-terminal fusion protein encoded by human alpha-fodrin cDNA. ( 9856838 )
1998
46
Neonatal lupus erythematosus: an unusual congenital presentation with cutaneous atrophy, erosions, alopecia, and pancytopenia. ( 9496802 )
1998
47
Neonatal lupus erythematosus: analysis of HLA class II alleles in mothers and siblings from seven Japanese families. ( 9039166 )
1997
48
Neonatal lupus erythematosus with congenital heart block and severe heart failure due to myocarditis and endocardititis of the mitral valve. ( 8796403 )
1996
49
Autoantibody response to the Ro/La particle may predict outcome in neonatal lupus erythematosus. ( 7774062 )
1995
50
Neonatal lupus erythematosus. Report of serological and immunogenetic studies in twins discordant for congenital heart block. ( 8148276 )
1994

Variations for Neonatal Lupus Erythematosus

Expression for Neonatal Lupus Erythematosus

Search GEO for disease gene expression data for Neonatal Lupus Erythematosus.

Pathways for Neonatal Lupus Erythematosus

GO Terms for Neonatal Lupus Erythematosus

Cellular components related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.63 HLA-DPB1 HLA-DQA1 RAB11FIP5
2 lysosomal membrane GO:0005765 9.5 ANXA6 HLA-DPB1 HLA-DQA1
3 trans-Golgi network membrane GO:0032588 9.43 HLA-DPB1 HLA-DQA1
4 endocytic vesicle membrane GO:0030666 9.4 HLA-DPB1 HLA-DQA1
5 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DPB1 HLA-DQA1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DPB1 HLA-DQA1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DPB1 HLA-DQA1
8 MHC class II protein complex GO:0042613 8.96 HLA-DPB1 HLA-DQA1
9 transport vesicle membrane GO:0030658 8.8 HLA-DPB1 HLA-DQA1 RAB11FIP5

Biological processes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.54 C4A HLA-DPB1 HLA-DQA1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.32 HLA-DPB1 HLA-DQA1
3 T cell costimulation GO:0031295 9.26 HLA-DPB1 HLA-DQA1
4 antigen processing and presentation GO:0019882 9.16 HLA-DPB1 HLA-DQA1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.96 HLA-DPB1 HLA-DQA1
6 interferon-gamma-mediated signaling pathway GO:0060333 8.8 HLA-DPB1 HLA-DQA1 TRIM21

Molecular functions related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DPB1 HLA-DQA1

Sources for Neonatal Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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