MCID: NNT042
MIFTS: 34

Neonatal Lupus Erythematosus

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Neonatal Lupus Erythematosus

MalaCards integrated aliases for Neonatal Lupus Erythematosus:

Name: Neonatal Lupus Erythematosus 60
Neonatal Systemic Lupus Erythematosus 74

Characteristics:

Orphanet epidemiological data:

60
neonatal lupus erythematosus
Prevalence: 1-9/100000 (United States); Age of onset: Neonatal;

Classifications:



External Ids:

ICD10 via Orphanet 35 M32.8
UMLS via Orphanet 75 C0409979
Orphanet 60 ORPHA398124
UMLS 74 C0409979

Summaries for Neonatal Lupus Erythematosus

MalaCards based summary : Neonatal Lupus Erythematosus, also known as neonatal systemic lupus erythematosus, is related to systemic lupus erythematosus and sjogren syndrome. An important gene associated with Neonatal Lupus Erythematosus is RAB11FIP5 (RAB11 Family Interacting Protein 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include heart, bone and neutrophil, and related phenotype is Increased cell size.

Wikipedia : 77 Neonatal lupus erythematosus is the occurrence of systemic lupus erythematosus (SLE) symptoms in an... more...

Related Diseases for Neonatal Lupus Erythematosus

Diseases in the Neonatal Lupus Erythematosus family:

Neonatal Systemic Lupus Erythematosus

Diseases related to Neonatal Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.3 C4A HLA-DPB1 HLA-DQA1 TRIM21
2 sjogren syndrome 29.1 SPTAN1 TRIM21
3 lupus erythematosus 11.0
4 atrial standstill 1 10.4
5 heart block, congenital 10.3
6 hepatitis 10.1
7 cholestasis 10.1
8 distal trisomy 9q 10.1
9 beryllium disease 10.0 HLA-DPB1 HLA-DQA1
10 oligoarticular juvenile idiopathic arthritis 10.0 HLA-DPB1 HLA-DQA1
11 hydrocephalus 10.0
12 liver disease 10.0
13 pancytopenia 10.0
14 vasculitis 10.0
15 takayasu arteritis 9.9 HLA-DPB1 HLA-DQA1
16 annular erythema 9.8
17 rheumatoid arthritis 9.8
18 citrullinemia, classic 9.8
19 cutis marmorata telangiectatica congenita 9.8
20 myasthenia gravis 9.8
21 langerhans cell histiocytosis 9.8
22 neutrophilic dermatosis, acute febrile 9.8
23 aplastic anemia 9.8
24 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
25 alopecia 9.8
26 arthritis 9.8
27 dilated cardiomyopathy 9.8
28 cutaneous lupus erythematosus 9.8
29 atrioventricular block 9.8
30 endocarditis 9.8
31 hepatitis a 9.8
32 telangiectasis 9.8
33 hellp syndrome 9.8
34 dermatitis 9.8
35 histiocytosis 9.8
36 turner syndrome 9.8
37 mixed connective tissue disease 9.8
38 aortic aneurysm 9.8
39 connective tissue disease 9.8
40 myocarditis 9.8
41 localized scleroderma 9.8
42 rere-related disorders 9.8
43 myasthenia gravis congenital 9.8
44 spastic paraparesis 9.8
45 subacute cutaneous lupus erythematosus 9.8
46 discoid lupus erythematosus 9.8
47 familial thyroid dyshormonogenesis 9.8
48 juvenile rheumatoid arthritis 9.8 HLA-DPB1 HLA-DQA1
49 autoimmune disease of musculoskeletal system 9.7 C4A TRIM21

Graphical network of the top 20 diseases related to Neonatal Lupus Erythematosus:



Diseases related to Neonatal Lupus Erythematosus

Symptoms & Phenotypes for Neonatal Lupus Erythematosus

GenomeRNAi Phenotypes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell size GR00098-A-4 8.62 HLA-DQA1 SPTAN1

Drugs & Therapeutics for Neonatal Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Neonatal Lupus Erythematosus

Genetic Tests for Neonatal Lupus Erythematosus

Anatomical Context for Neonatal Lupus Erythematosus

MalaCards organs/tissues related to Neonatal Lupus Erythematosus:

42
Heart, Bone, Neutrophil, Skin, Liver, B Cells

Publications for Neonatal Lupus Erythematosus

Articles related to Neonatal Lupus Erythematosus:

(show top 50) (show all 202)
# Title Authors Year
1
Neonatal Lupus Erythematosus: Varied Clinical Expression of a Spectral Disease. ( 30888956 )
2019
2
Cutaneous Neonatal Lupus Erythematosus: A Case Report. ( 29686954 )
2018
3
Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus. ( 30297329 )
2018
4
Neonatal Lupus Erythematosus in a newborn with Citrullinemia. ( 30414373 )
2018
5
Neonatal lupus erythematosus or Sweet syndrome? ( 30246125 )
2018
6
Neonatal lupus erythematosus. ( 28603203 )
2017
7
Discordant disease expression of neonatal lupus erythematosus in twins. ( 28585599 )
2017
8
Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review. ( 29116459 )
2017
9
A case of neonatal lupus erythematosus in a very low birth weight infant that suffered intraventricular hemorrhage at birth. ( 26872497 )
2016
10
Extensive aortic aneurysm associated with neonatal lupus erythematosus. ( 27212867 )
2016
11
Neonatal lupus erythematosus with congenital heart block in twins. ( 28051234 )
2016
12
Neonatal lupus erythematosus: a cutaneous cases based update. ( 26743447 )
2016
13
Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings. ( 27922246 )
2016
14
Unusual Skin Manifestations in Neonatal Lupus Erythematosus. ( 27276848 )
2015
15
Cytokine profile in two siblings with neonatal lupus erythematosus. ( 26711923 )
2015
16
Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus. ( 26269318 )
2015
17
Neonatal lupus erythematosus: a review of 123 cases in China. ( 26171790 )
2015
18
Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review. ( 25755869 )
2014
19
Neonatal lupus erythematosus: the use of telephone images in diagnosis. ( 24888545 )
2014
20
A 6-week-old boy with annular skin lesions. Neonatal lupus erythematosus. ( 24450316 )
2014
21
Marked histiocytic infiltration in neonatal lupus erythematosus. ( 24471465 )
2014
22
CNS vasculitis and stroke in neonatal lupus erythematosus: a case report and review of literature. ( 24508360 )
2014
23
A case of neonatal lupus erythematosus with a typical malar rash. ( 24407234 )
2014
24
Targetoid lesions and neutrophilic dermatosis: an initial clinical and histological presentation of neonatal lupus erythematosus. ( 23331164 )
2014
25
Neonatal lupus erythematosus: a 20-year retrospective study. ( 25391176 )
2014
26
Neonatal lupus erythematosus complicated by improved congenital complete heart block. ( 23910804 )
2013
27
Neonatal Lupus Erythematosus Presenting as Atypical Targetoid-like Lesions Involving Genitals and Soles of Feet Following Brief Sun Exposure. ( 23710267 )
2013
28
Neonatal lupus erythematosus mimicking extensive capillary malformation. ( 23819452 )
2013
29
Neonatal lupus erythematosus and its clinical variability. ( 22606966 )
2012
30
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 26344845 )
2012
31
Cutaneous neonatal lupus erythematosus. ( 23075661 )
2012
32
Facial telangiectasia: an unusual manifestation of neonatal lupus erythematosus. ( 22170760 )
2012
33
Neonatal lupus erythematosus. ( 22973504 )
2012
34
Picture of the month--a case of neonatal lupus erythematosus and associated hepatitis. ( 22393185 )
2012
35
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 22276811 )
2012
36
Congenital and neonatal lupus erythematosus: two case reports. ( 22892781 )
2012
37
Comment on: Early cholestasis in neonatal lupus erythematosus. Ann Saudi Med 2011; 31: 80-2. ( 21623063 )
2011
38
Early cholestasis in neonatal lupus erythematosus. ( 20864789 )
2011
39
Neonatal lupus erythematosus in identical twins, showing transient bullous lesions. ( 21793882 )
2011
40
Neonatal lupus erythematosus: a report of four cases. ( 21603821 )
2011
41
Neonatal lupus erythematosus: clinical character, investigation, and outcome. ( 21362029 )
2011
42
Cutaneous neonatal lupus erythematosus. ( 21362699 )
2011
43
Vitamin D deficiency presenting in an infant with neonatal lupus erythematosus. ( 21501313 )
2011
44
Neonatal lupus erythematosus associated with unilateral pectoralis major atrophy. ( 21553209 )
2011
45
Is annular erythema developing in a pregnant patient with Sjögren's syndrome a predictor of potential neonatal lupus erythematosus in the infant? ( 21039792 )
2010
46
Neonatal lupus erythematosus: three case reports and review of the Chinese literature. ( 20118099 )
2010
47
Targetoid lesions and neutrophilic dermatosis within neonatal lupus erythematosus: unusual clinical and histologic presentations. ( 20128992 )
2010
48
Neonatal lupus erythematosus: a possible role for anti-Sm antibodies. ( 20133347 )
2010
49
The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. ( 20538173 )
2010
50
Non-cardiac manifestations of neonatal lupus erythematosus. ( 20696019 )
2010

Variations for Neonatal Lupus Erythematosus

Expression for Neonatal Lupus Erythematosus

Search GEO for disease gene expression data for Neonatal Lupus Erythematosus.

Pathways for Neonatal Lupus Erythematosus

GO Terms for Neonatal Lupus Erythematosus

Cellular components related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.65 HLA-DPB1 HLA-DQA1 RAB11FIP5
2 Golgi membrane GO:0000139 9.63 HLA-DPB1 HLA-DQA1 RAB11FIP5
3 lysosomal membrane GO:0005765 9.5 ANXA6 HLA-DPB1 HLA-DQA1
4 trans-Golgi network membrane GO:0032588 9.43 HLA-DPB1 HLA-DQA1
5 endocytic vesicle membrane GO:0030666 9.4 HLA-DPB1 HLA-DQA1
6 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DPB1 HLA-DQA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DPB1 HLA-DQA1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DPB1 HLA-DQA1
9 MHC class II protein complex GO:0042613 8.96 HLA-DPB1 HLA-DQA1
10 transport vesicle membrane GO:0030658 8.8 HLA-DPB1 HLA-DQA1 RAB11FIP5

Biological processes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.5 C4A HLA-DPB1 HLA-DQA1
2 T cell receptor signaling pathway GO:0050852 9.37 HLA-DPB1 HLA-DQA1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DPB1 HLA-DQA1
4 antigen processing and presentation GO:0019882 9.16 HLA-DPB1 HLA-DQA1
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.96 HLA-DPB1 HLA-DQA1
6 interferon-gamma-mediated signaling pathway GO:0060333 8.8 HLA-DPB1 HLA-DQA1 TRIM21

Molecular functions related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DPB1 HLA-DQA1

Sources for Neonatal Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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