MCID: NNT042
MIFTS: 36

Neonatal Lupus Erythematosus

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Neonatal Lupus Erythematosus

MalaCards integrated aliases for Neonatal Lupus Erythematosus:

Name: Neonatal Lupus Erythematosus 59
Neonatal Systemic Lupus Erythematosus 73

Characteristics:

Orphanet epidemiological data:

59
neonatal lupus erythematosus
Prevalence: 1-9/100000 (United States); Age of onset: Neonatal;

Classifications:



External Ids:

Orphanet 59 ORPHA398124
UMLS via Orphanet 74 C0409979
ICD10 via Orphanet 34 M32.8
UMLS 73 C0409979

Summaries for Neonatal Lupus Erythematosus

MalaCards based summary : Neonatal Lupus Erythematosus, also known as neonatal systemic lupus erythematosus, is related to systemic lupus erythematosus and lupus erythematosus. An important gene associated with Neonatal Lupus Erythematosus is RAB11FIP5 (RAB11 Family Interacting Protein 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Immunologic Factors and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and neutrophil, and related phenotype is Increased cell size.

Wikipedia : 76 Neonatal lupus erythematosus is the occurrence of systemic lupus erythematosus (SLE) symptoms in an... more...

Related Diseases for Neonatal Lupus Erythematosus

Diseases in the Neonatal Lupus Erythematosus family:

Neonatal Systemic Lupus Erythematosus

Diseases related to Neonatal Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.7 C4A HLA-DPB1 HLA-DQA1 TRIM21
2 lupus erythematosus 11.0
3 atrial standstill 1 10.4
4 heart block, congenital 10.3
5 hepatitis 10.1
6 cholestasis 10.0
7 beryllium disease 10.0 HLA-DPB1 HLA-DQA1
8 oligoarticular juvenile idiopathic arthritis 10.0 HLA-DPB1 HLA-DQA1
9 takayasu arteritis 10.0 HLA-DPB1 HLA-DQA1
10 hydrocephalus 10.0
11 liver disease 10.0
12 pancytopenia 10.0
13 vasculitis 10.0
14 juvenile rheumatoid arthritis 9.9 HLA-DPB1 HLA-DQA1
15 leishmaniasis 9.9 HLA-DPB1 HLA-DQA1
16 autoimmune disease of musculoskeletal system 9.9 C4A TRIM21
17 diabetes mellitus, insulin-dependent 9.9 C4A HLA-DPB1 HLA-DQA1
18 celiac disease 1 9.8 HLA-DPB1 HLA-DQA1
19 annular erythema 9.8
20 rheumatoid arthritis 9.8
21 citrullinemia, classic 9.8
22 cutis marmorata telangiectatica congenita 9.8
23 myasthenia gravis 9.8
24 langerhans cell histiocytosis 9.8
25 neutrophilic dermatosis, acute febrile 9.8
26 aplastic anemia 9.8
27 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
28 alopecia 9.8
29 arthritis 9.8
30 dilated cardiomyopathy 9.8
31 cutaneous lupus erythematosus 9.8
32 atrioventricular block 9.8
33 endocarditis 9.8
34 hepatitis a 9.8
35 hellp syndrome 9.8
36 dermatitis 9.8
37 histiocytosis 9.8
38 turner syndrome 9.8
39 mixed connective tissue disease 9.8
40 aortic aneurysm 9.8
41 connective tissue disease 9.8
42 myocarditis 9.8
43 localized scleroderma 9.8
44 myasthenia gravis congenital 9.8
45 spastic paraparesis 9.8
46 subacute cutaneous lupus erythematosus 9.8
47 discoid lupus erythematosus 9.8
48 sjogren syndrome 9.8 SPTAN1 TRIM21

Graphical network of the top 20 diseases related to Neonatal Lupus Erythematosus:



Diseases related to Neonatal Lupus Erythematosus

Symptoms & Phenotypes for Neonatal Lupus Erythematosus

GenomeRNAi Phenotypes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell size GR00098-A-4 8.62 HLA-DQA1 SPTAN1

Drugs & Therapeutics for Neonatal Lupus Erythematosus

Drugs for Neonatal Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2, Phase 3,Not Applicable
2 Immunoglobulins, Intravenous Phase 2, Phase 3
3 Immunoglobulins Phase 2, Phase 3,Not Applicable
4 gamma-Globulins Phase 2, Phase 3
5 Antibodies Phase 2, Phase 3,Not Applicable
6 Rho(D) Immune Globulin Phase 2, Phase 3
7 Autoantibodies Phase 2, Phase 3
8
Hydroxychloroquine Approved Phase 2,Not Applicable 118-42-3 3652
9 Antiprotozoal Agents Phase 2,Not Applicable
10 Antiparasitic Agents Phase 2,Not Applicable
11 Antimalarials Phase 2,Not Applicable
12 Anti-Infective Agents Phase 2,Not Applicable
13 Antirheumatic Agents Phase 2,Not Applicable
14
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
16
Dalteparin Approved Not Applicable 9005-49-6
17
Heparin Approved, Investigational Not Applicable 9005-49-6 772 46507594
18
Enoxaparin Approved Not Applicable 9005-49-6 772
19
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
20
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
21
Nadroparin Approved, Investigational Not Applicable
22
protease inhibitors Not Applicable
23 Gastrointestinal Agents Not Applicable
24 Anti-Inflammatory Agents Not Applicable
25 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
26 Hormone Antagonists Not Applicable
27 glucocorticoids Not Applicable
28 Autonomic Agents Not Applicable
29 Antineoplastic Agents, Hormonal Not Applicable
30 Hormones Not Applicable
31 BB 1101 Not Applicable
32 HIV Protease Inhibitors Not Applicable
33 Peripheral Nervous System Agents Not Applicable
34 Antiemetics Not Applicable
35 Anti-Inflammatory Agents, Non-Steroidal Not Applicable
36 Cyclooxygenase Inhibitors Not Applicable
37 Analgesics Not Applicable
38 Calcium, Dietary Not Applicable
39 Anticoagulants Not Applicable
40 Analgesics, Non-Narcotic Not Applicable
41 Platelet Aggregation Inhibitors Not Applicable
42 calcium heparin Not Applicable
43 Heparin, Low-Molecular-Weight Not Applicable
44 Fibrinolytic Agents Not Applicable
45 Immunosuppressive Agents Not Applicable
46 Antipyretics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preventive IVIG Therapy for Congenital Heart Block Completed NCT00460928 Phase 2, Phase 3 intravenous immune globulin (IVIG)
2 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
3 Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus Completed NCT00007358 Not Applicable Dexamethasone or other corticosteroid
4 The Research Registry for Neonatal Lupus Recruiting NCT00074373
5 Prospective Maternal Surveillance of SSA (Sjögren Syndrome A) Positive Pregnancies Using a Hand-held Fetal Heart Rate Monitor Recruiting NCT02920346
6 Immunosuppressant Regimens for Living Fetuses Study Not yet recruiting NCT03671174 Not Applicable Prednisone;Hydroxychloroquine;Aspirin;low molecular weight heparin

Search NIH Clinical Center for Neonatal Lupus Erythematosus

Genetic Tests for Neonatal Lupus Erythematosus

Anatomical Context for Neonatal Lupus Erythematosus

MalaCards organs/tissues related to Neonatal Lupus Erythematosus:

41
Heart, Bone, Neutrophil, Skin, Liver, B Cells, Bone Marrow

Publications for Neonatal Lupus Erythematosus

Articles related to Neonatal Lupus Erythematosus:

(show top 50) (show all 201)
# Title Authors Year
1
Cutaneous Neonatal Lupus Erythematosus: A Case Report. ( 29686954 )
2018
2
Neonatal Lupus Erythematosus in a newborn with Citrullinemia. ( 30414373 )
2018
3
Neonatal lupus erythematosus or Sweet syndrome? ( 30246125 )
2018
4
Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus. ( 30297329 )
2018
5
Neonatal lupus erythematosus. ( 28603203 )
2017
6
Discordant disease expression of neonatal lupus erythematosus in twins. ( 28585599 )
2017
7
Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review. ( 29116459 )
2017
8
A case of neonatal lupus erythematosus in a very low birth weight infant that suffered intraventricular hemorrhage at birth. ( 26872497 )
2016
9
Extensive aortic aneurysm associated with neonatal lupus erythematosus. ( 27212867 )
2016
10
Neonatal lupus erythematosus with congenital heart block in twins. ( 28051234 )
2016
11
Neonatal lupus erythematosus: a cutaneous cases based update. ( 26743447 )
2016
12
Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings. ( 27922246 )
2016
13
Unusual Skin Manifestations in Neonatal Lupus Erythematosus. ( 27276848 )
2015
14
Cytokine profile in two siblings with neonatal lupus erythematosus. ( 26711923 )
2015
15
Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus. ( 26269318 )
2015
16
Neonatal lupus erythematosus: a review of 123 cases in China. ( 26171790 )
2015
17
Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review. ( 25755869 )
2014
18
Neonatal lupus erythematosus: the use of telephone images in diagnosis. ( 24888545 )
2014
19
A 6-week-old boy with annular skin lesions. Neonatal lupus erythematosus. ( 24450316 )
2014
20
Marked histiocytic infiltration in neonatal lupus erythematosus. ( 24471465 )
2014
21
CNS vasculitis and stroke in neonatal lupus erythematosus: a case report and review of literature. ( 24508360 )
2014
22
A case of neonatal lupus erythematosus with a typical malar rash. ( 24407234 )
2014
23
Targetoid lesions and neutrophilic dermatosis: an initial clinical and histological presentation of neonatal lupus erythematosus. ( 23331164 )
2014
24
Neonatal lupus erythematosus: a 20-year retrospective study. ( 25391176 )
2014
25
Neonatal lupus erythematosus complicated by improved congenital complete heart block. ( 23910804 )
2013
26
Neonatal Lupus Erythematosus Presenting as Atypical Targetoid-like Lesions Involving Genitals and Soles of Feet Following Brief Sun Exposure. ( 23710267 )
2013
27
Neonatal lupus erythematosus mimicking extensive capillary malformation. ( 23819452 )
2013
28
Neonatal lupus erythematosus and its clinical variability. ( 22606966 )
2012
29
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 26344845 )
2012
30
Cutaneous neonatal lupus erythematosus. ( 23075661 )
2012
31
Facial telangiectasia: an unusual manifestation of neonatal lupus erythematosus. ( 22170760 )
2012
32
Neonatal lupus erythematosus. ( 22973504 )
2012
33
Picture of the month--a case of neonatal lupus erythematosus and associated hepatitis. ( 22393185 )
2012
34
Neonatal Lupus Erythematosus Mimicking Extensive Capillary Malformation. ( 22276811 )
2012
35
Congenital and neonatal lupus erythematosus: two case reports. ( 22892781 )
2012
36
Comment on: Early cholestasis in neonatal lupus erythematosus. Ann Saudi Med 2011; 31: 80-2. ( 21623063 )
2011
37
Early cholestasis in neonatal lupus erythematosus. ( 20864789 )
2011
38
Neonatal lupus erythematosus in identical twins, showing transient bullous lesions. ( 21793882 )
2011
39
Neonatal lupus erythematosus: a report of four cases. ( 21603821 )
2011
40
Neonatal lupus erythematosus: clinical character, investigation, and outcome. ( 21362029 )
2011
41
Cutaneous neonatal lupus erythematosus. ( 21362699 )
2011
42
Vitamin D deficiency presenting in an infant with neonatal lupus erythematosus. ( 21501313 )
2011
43
Neonatal lupus erythematosus associated with unilateral pectoralis major atrophy. ( 21553209 )
2011
44
Is annular erythema developing in a pregnant patient with Sjögren's syndrome a predictor of potential neonatal lupus erythematosus in the infant? ( 21039792 )
2010
45
Targetoid lesions and neutrophilic dermatosis within neonatal lupus erythematosus: unusual clinical and histologic presentations. ( 20128992 )
2010
46
Neonatal lupus erythematosus: a possible role for anti-Sm antibodies. ( 20133347 )
2010
47
The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. ( 20538173 )
2010
48
Non-cardiac manifestations of neonatal lupus erythematosus. ( 20696019 )
2010
49
Neonatal lupus erythematosus: three case reports and review of the Chinese literature. ( 20118099 )
2010
50
Neonatal lupus erythematosus and cutis marmorata telangiectatica congenita-like lesions. ( 20064177 )
2009

Variations for Neonatal Lupus Erythematosus

Expression for Neonatal Lupus Erythematosus

Search GEO for disease gene expression data for Neonatal Lupus Erythematosus.

Pathways for Neonatal Lupus Erythematosus

GO Terms for Neonatal Lupus Erythematosus

Cellular components related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.65 HLA-DPB1 HLA-DQA1 RAB11FIP5
2 Golgi membrane GO:0000139 9.63 HLA-DPB1 HLA-DQA1 RAB11FIP5
3 lysosomal membrane GO:0005765 9.5 ANXA6 HLA-DPB1 HLA-DQA1
4 trans-Golgi network membrane GO:0032588 9.43 HLA-DPB1 HLA-DQA1
5 endocytic vesicle membrane GO:0030666 9.4 HLA-DPB1 HLA-DQA1
6 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DPB1 HLA-DQA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DPB1 HLA-DQA1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DPB1 HLA-DQA1
9 MHC class II protein complex GO:0042613 8.96 HLA-DPB1 HLA-DQA1
10 transport vesicle membrane GO:0030658 8.8 HLA-DPB1 HLA-DQA1 RAB11FIP5

Biological processes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.5 C4A HLA-DPB1 HLA-DQA1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DPB1 HLA-DQA1
3 antigen processing and presentation GO:0019882 9.16 HLA-DPB1 HLA-DQA1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.96 HLA-DPB1 HLA-DQA1
5 interferon-gamma-mediated signaling pathway GO:0060333 8.8 HLA-DPB1 HLA-DQA1 TRIM21

Molecular functions related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DPB1 HLA-DQA1

Sources for Neonatal Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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