MCID: NNT042
MIFTS: 38

Neonatal Lupus Erythematosus

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Neonatal Lupus Erythematosus

MalaCards integrated aliases for Neonatal Lupus Erythematosus:

Name: Neonatal Lupus Erythematosus 58
Neonatal Systemic Lupus Erythematosus 70

Characteristics:

Orphanet epidemiological data:

58
neonatal lupus erythematosus
Prevalence: 1-9/100000 (United States); Age of onset: Neonatal;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Neonatal Lupus Erythematosus

MalaCards based summary : Neonatal Lupus Erythematosus, also known as neonatal systemic lupus erythematosus, is related to heart block, congenital and lupus erythematosus. An important gene associated with Neonatal Lupus Erythematosus is RAB11FIP5 (RAB11 Family Interacting Protein 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include heart, liver and skin, and related phenotypes are autoimmune antibody positivity and hydrocephalus

Wikipedia : 73 Neonatal lupus erythematosus is the occurrence of systemic lupus erythematosus (SLE) symptoms in an... more...

Related Diseases for Neonatal Lupus Erythematosus

Diseases in the Neonatal Lupus Erythematosus family:

Neonatal Systemic Lupus Erythematosus

Diseases related to Neonatal Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 heart block, congenital 31.0 TRIM21 SPTAN1
2 lupus erythematosus 30.9 TRIM21 HLA-DQA1 C4A
3 autoimmune disease 30.4 TRIM21 HLA-DQA1 C4A
4 sjogren syndrome 29.9 TRIM21 SPTAN1
5 systemic lupus erythematosus 29.3 TRIM21 HLA-DQA1 HLA-DPB1 C4A
6 exanthem 10.5
7 cutaneous lupus erythematosus 10.5
8 connective tissue disease 10.5
9 atrioventricular block 10.5
10 thrombocytopenia 10.5
11 subacute cutaneous lupus erythematosus 10.5
12 telangiectasis 10.4
13 cholestasis 10.4
14 annular erythema 10.3
15 skin disease 10.3
16 splenomegaly 10.3
17 discoid lupus erythematosus 10.2
18 hydrocephalus 10.2
19 neutropenia 10.2
20 pancytopenia 10.2
21 bilirubin metabolic disorder 10.2
22 mixed connective tissue disease 10.2
23 hemolytic anemia 10.2
24 vasculitis 10.2
25 chondrodysplasia punctata syndrome 10.1
26 endocardial fibroelastosis 10.1
27 myasthenia gravis 10.1
28 hemophagocytic lymphohistiocytosis 10.1
29 third-degree atrioventricular block 10.1
30 nephrotic syndrome 10.1
31 dilated cardiomyopathy 10.1
32 hellp syndrome 10.1
33 keratosis 10.1
34 dermatitis 10.1
35 purpura 10.1
36 histiocytosis 10.1
37 liver disease 10.1
38 collagen disease 10.1
39 spastic paraparesis 10.1
40 seizure disorder 10.1
41 oligoarticular juvenile idiopathic arthritis 9.9 HLA-DQA1 HLA-DPB1
42 aplasia cutis congenita, nonsyndromic 9.9
43 atrial standstill 1 9.9
44 progressive familial heart block, type ia 9.9
45 hypertriglyceridemia, familial 9.9
46 dowling-degos disease 1 9.9
47 rheumatoid arthritis 9.9
48 thrombocytopenic purpura, autoimmune 9.9
49 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
50 wolff-parkinson-white syndrome 9.9

Graphical network of the top 20 diseases related to Neonatal Lupus Erythematosus:



Diseases related to Neonatal Lupus Erythematosus

Symptoms & Phenotypes for Neonatal Lupus Erythematosus

Human phenotypes related to Neonatal Lupus Erythematosus:

58 31 (show all 36)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 autoimmune antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0030057
2 hydrocephalus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000238
3 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
4 hyperkeratosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000962
5 elevated hepatic transaminase 58 31 occasional (7.5%) Occasional (29-5%) HP:0002910
6 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
7 dilated cardiomyopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001644
8 atrioventricular block 58 31 occasional (7.5%) Occasional (29-5%) HP:0001678
9 neutropenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001875
10 cutaneous photosensitivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000992
11 abnormality of the cerebral white matter 58 31 occasional (7.5%) Occasional (29-5%) HP:0002500
12 maculopapular exanthema 58 31 occasional (7.5%) Occasional (29-5%) HP:0040186
13 parakeratosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001036
14 malar rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0025300
15 erythematous plaque 58 31 occasional (7.5%) Occasional (29-5%) HP:0025474
16 macrocephaly 58 31 very rare (1%) Very rare (<4-1%) HP:0000256
17 splenomegaly 58 31 very rare (1%) Very rare (<4-1%) HP:0001744
18 skeletal dysplasia 58 31 very rare (1%) Very rare (<4-1%) HP:0002652
19 prolonged qt interval 58 31 very rare (1%) Very rare (<4-1%) HP:0001657
20 hemolytic anemia 58 31 very rare (1%) Very rare (<4-1%) HP:0001878
21 hepatic failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001399
22 abnormality of the respiratory system 58 31 very rare (1%) Very rare (<4-1%) HP:0002086
23 abnormal bleeding 58 31 very rare (1%) Very rare (<4-1%) HP:0001892
24 aplastic anemia 58 31 very rare (1%) Very rare (<4-1%) HP:0001915
25 basal ganglia calcification 58 31 very rare (1%) Very rare (<4-1%) HP:0002135
26 abnormal electrophysiology of sinoatrial node origin 58 31 very rare (1%) Very rare (<4-1%) HP:0011702
27 anemia 58 Occasional (29-5%)
28 arrhythmia 58 Occasional (29-5%)
29 skin rash 58 Occasional (29-5%)
30 abnormality of the liver 58 Frequent (79-30%)
31 cholestasis 58 Excluded (0%)
32 heart block 58 Occasional (29-5%)
33 abnormality of the skin 58 Frequent (79-30%)
34 abnormal heart morphology 58 Very rare (<4-1%)
35 pancytopenia 58 Very rare (<4-1%)
36 abnormality of blood and blood-forming tissues 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell size GR00098-A-4 8.62 HLA-DQA1 SPTAN1

Drugs & Therapeutics for Neonatal Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Neonatal Lupus Erythematosus

Genetic Tests for Neonatal Lupus Erythematosus

Anatomical Context for Neonatal Lupus Erythematosus

MalaCards organs/tissues related to Neonatal Lupus Erythematosus:

40
Heart, Liver, Skin, B Cells, Bone Marrow, Bone

Publications for Neonatal Lupus Erythematosus

Articles related to Neonatal Lupus Erythematosus:

(show top 50) (show all 369)
# Title Authors PMID Year
1
Neonatal Lupus Erythematosus Presenting as Neonatal Acute Liver Failure. 61
33146881 2021
2
Ethnicity and Neonatal Lupus Erythematosus Manifestations Risk in a Large Multi-Ethnic Cohort. 61
33795326 2021
3
Synchronous skin lesions in mother and baby with neonatal lupus erythematosus. 61
33694029 2021
4
Neonatal lupus erythematosus presenting as orolabial ulcerations: Two cases and a review of the literature. 61
33675085 2021
5
Neonatal Lupus Erythematosus. 61
33760008 2021
6
Macrophage activation syndrome in a newborn: report of a case associated with neonatal lupus erythematosus and a summary of the literature. 61
33568193 2021
7
Neonatal systemic lupus erythematosus syndrome presenting as 4 months of 'persistent ringworm'. 61
32033957 2021
8
Neonatal lupus erythematosus - practical guidelines. 61
33470961 2021
9
[Neonatal lupus erythematosus: Suspect and diagnosis]. 61
33478848 2021
10
Neonatal lupus presenting as a non-specific rash in primary care. 61
33318248 2020
11
Neonatal lupus erythematosus exacerbated by vaccination. 61
32881039 2020
12
[An infant with facial skin lesions]. 61
33332047 2020
13
Clinical Features, Autoantibodies, and Outcome of Neonatal Lupus Erythematosus. 61
33103534 2020
14
Cutaneous sequelae in neonatal lupus: A retrospective cohort study. 61
31626881 2020
15
The First Case of an Infant with Familial A20 Haploinsufficiency in Korea. 61
32743991 2020
16
Congenital onset of neonatal lupus erythematosus. 61
32366515 2020
17
A Neonate With Annular Cutaneous Lesions. 61
32789076 2020
18
Neonatal lupus erythematosus presenting with rash, thrombocytopenia compounded by cytomegalovirus colonisation: a diagnostic dilemma. 61
32532904 2020
19
Retrospective, single-center case series of neonatal lupus. 61
32110851 2020
20
[Polymorphism and differential diagnosis of neonatal lupus erythematosus]. 61
32171550 2020
21
Neonatal lupus erythematosus. 61
32071108 2020
22
Geoepidemiology and clinical characteristics of neonatal lupus erythematosus: a systematic literature review of individual patients’ data 61
31905489 2020
23
Clinical characteristics of pediatric cutaneous lupus erythematosus: experience from a tertiary referral center in Korea. 61
31112454 2019
24
Systemic lupus erythematosus in pregnancy: high risk, high reward. 61
30676534 2019
25
Neutrophilic figurate erythema of infancy: A diagnostic challenge. 61
30430608 2019
26
Neonatal Lupus Erythematosus: Varied Clinical Expression of a Spectral Disease. 61
30888956 2019
27
Telangiectasia-like lesions revealing neonatal lupus erythematosus. 61
32851278 2018
28
Effect of in utero hydroxychloroquine exposure on the development of cutaneous neonatal lupus erythematosus. 61
30297329 2018
29
Two case reports of neonatal autoantibody-associated congenital heart block. 61
30407356 2018
30
Neonatal lupus erythematosus or Sweet syndrome? 61
30246125 2018
31
Pulmonary involvement in neonatal lupus: a challenging diagnosis - case report and literature review. 61
30414372 2018
32
Neonatal Lupus Erythematosus in a newborn with Citrullinemia. 61
30414373 2018
33
A case of neonatal lupus erythematosus in a very low-birth-weight infant that suffered intraventricular hemorrhage at birth. 61
26872497 2018
34
Cutaneous Neonatal Lupus Erythematosus: A Case Report. 61
29686954 2018
35
Van Lohuizen Syndrome - A Case Report with a Diagnostic Delay of Four Years. 61
29483988 2018
36
Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review. 61
29116459 2017
37
Discordant disease expression of neonatal lupus erythematosus in twins. 61
28585599 2017
38
Warm antibody hemolytic anemia-a rare presentation of neonatal lupus. 61
27516434 2017
39
Management of systemic lupus erythematosus during pregnancy: challenges and solutions. 61
28331377 2017
40
Neonatal lupus erythematosus. 61
28603203 2017
41
The Child as a Surrogate for Diagnosis of Lupus in the Mother. 61
28386505 2017
42
Neonatal lupus erythematosus with congenital heart block in twins. 61
28051234 2016
43
Maternal predictive factors for fetal congenital heart block in pregnant mothers positive for anti-SS-A antibodies. 61
26457409 2016
44
A 10-year retrospective study of neonatal lupus erythematous in China. 61
27007840 2016
45
Extensive aortic aneurysm associated with neonatal lupus erythematosus. 61
27212867 2016
46
Cutaneous Lupus Erythematosus in Children: Experience from a Tertiary Care Pediatric Dermatology Clinic. 61
27001318 2016
47
Neonatal lupus erythematosus: a cutaneous cases based update. 61
26743447 2016
48
Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings. 61
27922246 2016
49
Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus. 61
26269318 2015
50
Cytokine profile in two siblings with neonatal lupus erythematosus. 61
26711923 2015

Variations for Neonatal Lupus Erythematosus

Expression for Neonatal Lupus Erythematosus

Search GEO for disease gene expression data for Neonatal Lupus Erythematosus.

Pathways for Neonatal Lupus Erythematosus

GO Terms for Neonatal Lupus Erythematosus

Cellular components related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.5 HLA-DQA1 HLA-DPB1 ANXA6
2 trans-Golgi network membrane GO:0032588 9.43 HLA-DQA1 HLA-DPB1
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DQA1 HLA-DPB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DQA1 HLA-DPB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DQA1 HLA-DPB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DQA1 HLA-DPB1
7 MHC class II protein complex GO:0042613 8.96 HLA-DQA1 HLA-DPB1
8 transport vesicle membrane GO:0030658 8.8 RAB11FIP5 HLA-DQA1 HLA-DPB1

Biological processes related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DQA1 HLA-DPB1
2 antigen processing and presentation GO:0019882 9.16 HLA-DQA1 HLA-DPB1
3 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.96 HLA-DQA1 HLA-DPB1
4 interferon-gamma-mediated signaling pathway GO:0060333 8.8 TRIM21 HLA-DQA1 HLA-DPB1

Molecular functions related to Neonatal Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DQA1 HLA-DPB1

Sources for Neonatal Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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