MCID: NNT006
MIFTS: 29

Neonatal Myasthenia Gravis

Categories: Bone diseases, Eye diseases, Fetal diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Myasthenia Gravis

MalaCards integrated aliases for Neonatal Myasthenia Gravis:

Name: Neonatal Myasthenia Gravis 12 15 17
Myasthenia Gravis, Neonatal 44

Classifications:



External Ids:

Disease Ontology 12 DOID:14043
ICD9CM 34 775.2
MeSH 44 D020941
SNOMED-CT 67 82178003
UMLS 70 C0158982

Summaries for Neonatal Myasthenia Gravis

MalaCards based summary : Neonatal Myasthenia Gravis, also known as myasthenia gravis, neonatal, is related to myasthenia gravis and ptosis. An important gene associated with Neonatal Myasthenia Gravis is CHRNG (Cholinergic Receptor Nicotinic Gamma Subunit), and among its related pathways/superpathways are Degradation of the extracellular matrix and Agrin Interactions at Neuromuscular Junction. Affiliated tissues include eye, thymus and lung, and related phenotypes are muscle and respiratory system

Related Diseases for Neonatal Myasthenia Gravis

Diseases in the Neonatal Myasthenia Gravis family:

Transient Neonatal Myasthenia Gravis

Diseases related to Neonatal Myasthenia Gravis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 myasthenia gravis 31.4 MUSK LRP4 CHRNG AGRN
2 ptosis 29.3 MUSK LRP4 IGHMBP2 COLQ CHRNG
3 congenital myasthenic syndrome 28.8 MUSK LRP4 COLQ CHRNG AGRN
4 neuromuscular disease 28.4 MUSK LRP4 IGHMBP2 COLQ CHRNG AGRN
5 transient neonatal myasthenia gravis 11.6
6 pyloric stenosis 10.2
7 autoimmune disease 10.1
8 respiratory failure 10.1
9 hypertrophic pyloric stenosis 10.1
10 polyhydramnios 10.1
11 hypotonia 10.1
12 congenital amyoplasia 10.1
13 systemic lupus erythematosus 10.0
14 pulmonary hypertension, primary, 1 10.0
15 pyloric stenosis, infantile hypertrophic, 1 10.0
16 distal arthrogryposis 10.0
17 blood group incompatibility 10.0
18 lung disease 10.0
19 lupus erythematosus 10.0
20 juvenile myasthenia gravis 10.0
21 uterine inversion 10.0 LRP4 COLQ
22 autosomal recessive distal hereditary motor neuronopathy 9.9 LAS1L IGHMBP2
23 diaphragmatic eventration 9.9 LAS1L IGHMBP2
24 spinal muscular atrophy, distal, autosomal recessive, 1 9.8 LAS1L IGHMBP2
25 ocular motility disease 9.7 MUSK COLQ
26 myasthenic syndrome, congenital, 21, presynaptic 9.7 COLQ AGRN
27 autoimmune disease of peripheral nervous system 9.7 MUSK AGRN
28 postsynaptic congenital myasthenic syndromes 9.7 MUSK LRP4 AGRN
29 cenani-lenz syndactyly syndrome 9.6 MUSK LRP4 AGRN
30 thymus gland disease 9.6 MUSK LRP4 AGRN
31 thymus cancer 9.6 MUSK LRP4 AGRN
32 peripheral nervous system disease 9.4 MUSK COLQ CHRNG AGRN
33 neuromuscular junction disease 9.2 MUSK LRP4 COLQ CHRNG AGRN

Graphical network of the top 20 diseases related to Neonatal Myasthenia Gravis:



Diseases related to Neonatal Myasthenia Gravis

Symptoms & Phenotypes for Neonatal Myasthenia Gravis

MGI Mouse Phenotypes related to Neonatal Myasthenia Gravis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.35 AGRN CHRNG IGHMBP2 LRP4 MUSK
2 respiratory system MP:0005388 9.02 AGRN CHRNG IGHMBP2 LRP4 MUSK

Drugs & Therapeutics for Neonatal Myasthenia Gravis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Neonatal Myasthenia Gravis

Cochrane evidence based reviews: myasthenia gravis, neonatal

Genetic Tests for Neonatal Myasthenia Gravis

Anatomical Context for Neonatal Myasthenia Gravis

MalaCards organs/tissues related to Neonatal Myasthenia Gravis:

40
Eye, Thymus, Lung

Publications for Neonatal Myasthenia Gravis

Articles related to Neonatal Myasthenia Gravis:

(show top 50) (show all 100)
# Title Authors PMID Year
1
Transient neonatal myasthenia gravis: refining risk estimate for infants born to women with myasthenia gravis. 61
33597740 2021
2
Neuromuscular Junction Disorders and Floppy Infant Syndrome: A Comprehensive Review. 61
32071826 2020
3
Myasthenia Gravis with Anti-Muscle-Specific Tyrosine Kinase Antibody during Pregnancy and Risk of Neonatal Myasthenia Gravis: A Case Report and Review of the Literature. 61
32308606 2020
4
An Update: Myasthenia Gravis and Pregnancy. 61
29655454 2018
5
Transient neonatal myasthenia gravis with infantile hypertrophic pyloric stenosis: coincidence or causation? 61
29099348 2018
6
Intravenous immunoglobulin as monotherapy for myasthenia gravis during pregnancy. 61
29246598 2017
7
The Role of Sugammadex in Symptomatic Transient Neonatal Myasthenia Gravis: A Case Report. 61
28691986 2017
8
Transient neonatal myasthenia gravis due to a mother with ocular onset of anti-muscle specific kinase myasthenia gravis. 61
28495046 2017
9
Clinical follow-up of pregnancy in myasthenia gravis patients. 61
28256306 2017
10
50 Years Ago in The Journal of Pediatrics: Neonatal Myasthenia Gravis. 61
27017463 2016
11
Seronegative Maternal Ocular Myasthenia Gravis and Delayed Transient Neonatal Myasthenia Gravis. 61
26989568 2016
12
Fetal acetylcholine receptor inactivation syndrome: A myopathy due to maternal antibodies. 61
25566546 2015
13
Ephedrine for myasthenia gravis, neonatal myasthenia and the congenital myasthenic syndromes. 61
25515947 2014
14
Prenatal immunomodulation treatment in neonatal myasthenia gravis. 61
23982940 2013
15
[A pregnant patient with anti-MuSK antibody positive myasthenia gravis and her infant with transient neonatal myasthenia gravis]. 61
21485163 2011
16
Acquired myasthenia gravis in childhood. 61
20581680 2010
17
Marked hypotonia in an infant of a mother with Devic disease. 61
20028941 2010
18
Transient neonatal myasthenia gravis revealing a myasthenia gravis and a systemic lupus erythematosus in the mother: case report and review of the literature. 61
19488958 2010
19
Transient neonatal myasthenia gravis in a baby born to a mother with new-onset anti-MuSK-mediated myasthenia gravis. 61
19955986 2009
20
[Antibodies in myasthenia gravis]. 61
19162288 2009
21
Severe neonatal myasthenia due to maternal anti-MuSK antibodies. 61
18434154 2008
22
Isolated facial and bulbar paresis: a persistent manifestation of neonatal myasthenia gravis. 61
18195270 2008
23
Can neonatal myasthenia gravis be predicted? 61
18681836 2008
24
Outcome of myasthenia gravis mothers and their infants. 61
17912986 2007
25
[Myasthenia gravis and pregnancy: clinical course and management of delivery and the postpartum phase]. 61
16585888 2006
26
Pregnancy complicated by Myasthenia gravis - twelve years experience. 61
16264394 2005
27
Myasthenia gravis and pregnancy: clinical implications and neonatal outcome. 61
15546494 2004
28
Seronegative neonatal myasthenia gravis in one of the twins. 61
15475637 2004
29
Pediatric myasthenia gravis and velopharyngeal incompetence. 61
15126014 2004
30
Myasthenia gravis in childhood. 61
15530139 2004
31
[Transient neonatal myasthenia gravis]. 61
12242967 2002
32
Myasthenia gravis in pregnancy: report on 69 cases. 61
12128277 2002
33
[Transient neonatal myasthenia gravis]. 61
11596403 2001
34
[Neonatal myasthenia gravis]. 61
10761602 2000
35
[Steinert's myotonic dystrophy: severe neonatal form with unknown family history]. 61
11424841 2000
36
Intravenous immunoglobulin in neonatal myasthenia gravis. 61
10586190 1999
37
Failure of intravenously administered immunoglobulin in the treatment of neonatal myasthenia gravis. 61
9931536 1999
38
High-dose intravenous immunoglobulin in transient neonatal myasthenia gravis. 61
9535308 1998
39
The fetal/adult acetylcholine receptor antibody ratio in mothers with myasthenia gravis as a marker for transfer of the disease to the newborn. 61
9008493 1997
40
[Transient neonatal myasthenia gravis in premature infants: diagnostic difficulties and value of anticholinesterase therapy]. 61
8548006 1995
41
Experimental neonatal autoimmune myasthenia gravis: an immunohistochemical, ultrastructural and electrophysiological study of the motor end-plate. 61
8543956 1995
42
Transient neonatal myasthenia gravis and pyloric stenosis. 61
8534471 1995
43
[Transient neonatal myasthenia gravis]. 61
7885685 1995
44
Neonatal myasthenia gravis and the role of agalactosyl IgG. 61
8679902 1995
45
Association of neonatal myasthenia gravis with antibodies against the fetal acetylcholine receptor. 61
8040310 1994
46
[The therapeutic strategy in transient neonatal myasthenia gravis]. 61
17974387 1994
47
The role of intrapartum vibroacoustic stimulation in the prediction of neonatal myasthenia gravis. 61
8022331 1994
48
Myasthenia gravis with polyhydramnios in the fetus of an asymptomatic mother. 61
8372081 1993
49
[Congenital myasthenia with esophageal involvement]. 61
8338415 1993
50
[Plasmapheresis in neurology. Critical analysis of indications and protocols]. 61
1308410 1992

Variations for Neonatal Myasthenia Gravis

Expression for Neonatal Myasthenia Gravis

Search GEO for disease gene expression data for Neonatal Myasthenia Gravis.

Pathways for Neonatal Myasthenia Gravis

Pathways related to Neonatal Myasthenia Gravis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 MUSK LRP4 AGRN
2 10.71 MUSK AGRN
3 10.56 MUSK LRP4 AGRN

GO Terms for Neonatal Myasthenia Gravis

Cellular components related to Neonatal Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.46 MUSK COLQ CHRNG AGRN
2 basement membrane GO:0005604 9.26 COLQ AGRN
3 synapse GO:0045202 9.26 MUSK COLQ CHRNG AGRN
4 neuromuscular junction GO:0031594 8.8 MUSK LRP4 COLQ

Biological processes related to Neonatal Myasthenia Gravis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse organization GO:0050808 9.32 LRP4 AGRN
2 neuromuscular junction development GO:0007528 9.26 MUSK AGRN
3 receptor clustering GO:0043113 9.16 LRP4 AGRN
4 skeletal muscle acetylcholine-gated channel clustering GO:0071340 9.13 MUSK LRP4 COLQ
5 regulation of synaptic growth at neuromuscular junction GO:0008582 8.8 MUSK COLQ AGRN

Sources for Neonatal Myasthenia Gravis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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