MCID: NNT004
MIFTS: 36

Neonatal Respiratory Failure

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Neonatal Respiratory Failure

MalaCards integrated aliases for Neonatal Respiratory Failure:

Name: Neonatal Respiratory Failure 12 15 70
Respiratory Failure of Newborn 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11161
ICD9CM 34 770.84
SNOMED-CT 67 95619009
ICD10 32 P28.5
UMLS 70 C0521648

Summaries for Neonatal Respiratory Failure

Disease Ontology : 12 A respiratory failure that is characterized by inadequate gas exchange by the respiratory system in neonates.

MalaCards based summary : Neonatal Respiratory Failure, also known as respiratory failure of newborn, is related to meconium aspiration syndrome and respiratory distress syndrome in premature infants. An important gene associated with Neonatal Respiratory Failure is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and FOXA1 transcription factor network. Affiliated tissues include lung, endothelial and fetal lung, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Neonatal Respiratory Failure

Diseases related to Neonatal Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 meconium aspiration syndrome 30.6 SFTPB SCGB1A1 ABCA3
2 respiratory distress syndrome in premature infants 30.4 SFTPC SFTPB ABCA3
3 diaphragmatic hernia, congenital 30.2 TBX4 SFTPC SFTPB NKX2-1 FOXF1
4 bronchopulmonary dysplasia 30.1 SFTPB SCGB1A1
5 surfactant dysfunction 30.0 SFTPC SFTPB ABCA3
6 respiratory failure 30.0 SFTPD SFTPC SFTPB SCGB1A1 NKX2-1 LMOD3
7 adult respiratory distress syndrome 29.5 SFTPD SFTPC SFTPB SCGB1A1 ABCA3
8 pulmonary interstitial emphysema 29.3 TBX4 SFTPD SFTPC SFTPB ABCA3
9 interstitial lung disease 29.3 SFTPD SFTPC SFTPB SFTPA2 NKX2-1 ABCA3
10 lung disease 29.2 SFTPD SFTPC SFTPB SFTPA2 SCGB1A1 NKX2-1
11 newborn respiratory distress syndrome 29.0 SFTPD SFTPC SFTPB SFTPA2 SCGB1A1 NKX2-1
12 respiratory distress syndrome, infant 10.3 SFTPC ABCA3
13 chronic congestive splenomegaly 10.2 SFTPC ABCA3
14 pulmonary hemosiderosis 10.2 SFTPB ABCA3
15 pulmonary fibrosis predisposition 10.2 SFTPC SFTPA2
16 lung carcinoma in situ 10.2 SFTPC NKX2-1
17 pulmonary adenocarcinoma in situ 10.2 SFTPC NKX2-1
18 pneumothorax 10.2
19 sclerosing hemangioma 10.2 SFTPB NKX2-1
20 surfactant metabolism dysfunction, pulmonary, 1 10.1 SFTPC SFTPB ABCA3
21 tracheal agenesis 10.1 SFTPD SFTPB
22 paraquat lung 10.1 SFTPB SCGB1A1
23 pulmonary sclerosing hemangioma 10.1 SFTPB NKX2-1
24 ventilation pneumonitis 10.1 SFTPD ABCA3
25 pulmonary hypertension 10.1
26 toxic pneumonitis 10.1 SFTPB SCGB1A1
27 diaphragm disease 10.1 SFTPC SFTPB
28 tracheomalacia 10.1 TBX4 FOXF1
29 tracheal disease 10.1 TBX4 FOXF1
30 subleukemic leukemia 10.1 SFTPC SCGB1A1
31 cardiomyopathy, familial hypertrophic, 20 10.0 SFTPB SCGB1A1
32 patent ductus arteriosus 1 10.0
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
34 sensorineural hearing loss 10.0
35 persistent fetal circulation syndrome 10.0
36 myotonic dystrophy 10.0
37 hypotonia 10.0
38 alveoli adenoma 10.0 SFTPC SCGB1A1 NKX2-1
39 bronchial benign neoplasm 10.0 SFTPC SCGB1A1 NKX2-1
40 papillary adenoma 10.0 SFTPC SCGB1A1 NKX2-1
41 pulmonary alveolar proteinosis 10.0 SFTPD SFTPC SFTPB
42 respiratory system benign neoplasm 10.0 SFTPC SCGB1A1 NKX2-1
43 lung benign neoplasm 10.0 SFTPC SCGB1A1 NKX2-1
44 pulmonary alveolar microlithiasis 10.0 SFTPD SFTPA2 ABCA3
45 cryptogenic organizing pneumonia 9.9 SFTPD SFTPC SFTPA2
46 lipid pneumonia 9.9 TBX4 SFTPC SFTPB ABCA3
47 hermansky-pudlak syndrome 9.9 SFTPC SFTPB SFTPA2 ABCA3
48 lung adenoma 9.9 SFTPC SCGB1A1
49 chorea, benign hereditary 9.9
50 glioma susceptibility 1 9.9

Graphical network of the top 20 diseases related to Neonatal Respiratory Failure:



Diseases related to Neonatal Respiratory Failure

Symptoms & Phenotypes for Neonatal Respiratory Failure

MGI Mouse Phenotypes related to Neonatal Respiratory Failure:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 ABCA3 FOXF1 LMOD3 NKX2-1 RCN3 SCGB1A1
2 mortality/aging MP:0010768 9.65 ABCA3 FOXF1 NKX2-1 RCN3 SCGB1A1 SFTPB
3 respiratory system MP:0005388 9.28 ABCA3 FOXF1 NKX2-1 RCN3 SCGB1A1 SFTPB

Drugs & Therapeutics for Neonatal Respiratory Failure

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Orotracheal CPAP ( Gregory System) for Treatment of Respiratory Failure in Newborns Unknown status NCT01379820 Phase 2, Phase 3
2 A Study of Bi-Level Positive Airway Pressure (BIPAP) Versus Non Invasive Positive Pressure Ventilation (NIPPV) for Neonatal Respiratory Failure Unknown status NCT01318824 Phase 3
3 Nasal Intermittent Mandatory Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants of the NEOCOSUR Network. Unknown status NCT01778829 Phase 3
4 Randomised Controlled Trial of Pressure-limited Ventilation Versus Volume-targeted Ventilation in Prematurely Born Infants Completed NCT01531010
5 Is Nasal Septum-tragus Length Safe in Neonatal Endotracheal Intubation? Completed NCT03591835
6 Randomised Trial Comparing Assist Control Ventilation to Pressure Support Ventilation During Weaning Completed NCT01376544
7 Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room Completed NCT03166826
8 Validation of a Novel Oxygen Consumption Measurement Technique in Neonates Completed NCT03154112
9 Hypothermia as Neuroprotection During ECMO: Is Brain MRI a Biomarker of Outcomes? Withdrawn NCT01675388

Search NIH Clinical Center for Neonatal Respiratory Failure

Genetic Tests for Neonatal Respiratory Failure

Anatomical Context for Neonatal Respiratory Failure

MalaCards organs/tissues related to Neonatal Respiratory Failure:

40
Lung, Endothelial, Fetal Lung, Bone, Heart, Brain, Kidney

Publications for Neonatal Respiratory Failure

Articles related to Neonatal Respiratory Failure:

(show top 50) (show all 249)
# Title Authors PMID Year
1
Three Infants with Pathogenic Variants in the ABCA3 Gene: Presentation, Treatment, and Clinical Course. 61
33359301 2021
2
Lethal Neonatal Respiratory Failure by Perinatal Transmission of Ureaplasma Parvum after Maternal PPROM. 61
33339061 2020
3
Functional Genomics of ABCA3 Variants. 61
32692933 2020
4
Factors Behind Decline of Venovenous Extracorporeal Membrane Oxygenation to Support Neonatal Respiratory Failure. 61
32195900 2020
5
Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter. 61
32532878 2020
6
Case 1: Primary Neonatal Respiratory Failure. 61
32482702 2020
7
Extracorporeal Life Support Organization (ELSO): Guidelines for Neonatal Respiratory Failure. 61
32282347 2020
8
Complications and mortality of venovenous extracorporeal membrane oxygenation in the treatment of neonatal respiratory failure: a systematic review and meta-analysis. 61
32380985 2020
9
Improvement of exercise capacity following neonatal respiratory failure: A randomized controlled trial. 61
31756267 2020
10
Etiology and management of early pregnancy renal anhydramnios: Is there a place for serial amnioinfusions? 61
32003482 2020
11
The Etiology of Neonatal Intensive Care Unit Death in Extremely Low Birth Weight Infants: A Multicenter Survey in China. 61
32102093 2020
12
The role of ECMO in the management of congenital diaphragmatic hernia. 61
31472951 2020
13
Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth. 61
32211389 2020
14
[Research advances in the methods for weaning from high-frequency oscillatory ventilation in neonates]. 61
31874666 2019
15
Modes and strategies for providing conventional mechanical ventilation in neonates. 61
31785591 2019
16
Lung ultrasound in the diagnosis of neonatal respiratory failure prior to patient transport. 61
31361036 2019
17
Clinical, Histopathological, and Molecular Diagnostics in Lethal Lung Developmental Disorders. 61
31189067 2019
18
Right Diaphragmatic Peak Motion Velocities on Pulsed Wave Tissue Doppler Imaging in Neonates: Method, Reproducibility, and Reference Values. 61
30793336 2019
19
Admission volume is associated with mortality of neonatal respiratory failure in emerging neonatal intensive care units. 61
29385861 2019
20
Pediatric Extracorporeal Membrane Oxygenation Mortality Is Related to Extracorporeal Membrane Oxygenation Volume in US Hospitals. 61
30694751 2019
21
Neonatal Lung Disease Associated with TBX4 Mutations. 61
30413314 2019
22
Positive end-expiratory pressure for preterm infants requiring conventional mechanical ventilation for respiratory distress syndrome or bronchopulmonary dysplasia. 61
30820939 2019
23
Is Benign Hereditary Chorea Really Benign? Brain-Lung-Thyroid Syndrome Caused by NKX2-1 Mutations. 61
30746413 2019
24
Observation of curative effect of nasal continuous positive airway pressure combined with high-dose ambroxol for neonatal respiratory failure. 61
30203757 2018
25
Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. 61
29972353 2018
26
[Consensus on extracorporeal membrane oxygenation support for neonatal respiratory failure]. 61
29783816 2018
27
Effect of pump type on outcomes in neonates with congenital diaphragmatic hernia requiring ECMO. 61
29788843 2018
28
Infants with Atypical Presentations of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins Who Underwent Bilateral Lung Transplantation. 61
29198536 2018
29
[Risk factors for elevated serum total bile acid in preterm infants]. 61
29530114 2018
30
Double aortic arch presenting as neonatal respiratory failure in the delivery room. 61
29248031 2018
31
Unusual long survival despite severe lung disease of a child with biallelic loss of function mutations in ABCA-3. 61
29719811 2018
32
Clinical Pearls in Venovenous Extracorporeal Life Support for Adult Respiratory Failure. 61
28885377 2018
33
Neonatal fractures as a presenting feature of LMOD3-associated congenital myopathy. 61
28815944 2017
34
Mortality of neonatal respiratory failure from Chinese northwest NICU network. 61
27651118 2017
35
Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. 61
28504997 2017
36
Venoarterial Extracorporeal Life Support for Neonatal Respiratory Failure: Indications and Impact on Mortality. 61
27984316 2017
37
The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate. 61
28808495 2017
38
Extracorporeal Membrane Oxygenation for Severe Pediatric Respiratory Failure. 61
28546375 2017
39
Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma. 61
28116951 2017
40
Neonatal respiratory failure due to ABCA3 deficiency. 61
28038995 2017
41
[Cost effectiveness and budget impact analysis of inhaled nitric oxide in a neonatal unit from the perspective of the public health system]. 61
27268936 2016
42
[Congenital neuromuscular diseases with neonatal respiratory failure excluding myotonic dystrophy type 1 and infantile spinal muscular atrophy. Diagnosis strategy according to a 19-child series]. 61
27375179 2016
43
Fatal respiratory disease due to a homozygous intronic ABCA3 mutation: a case report. 61
27670912 2016
44
Nitric oxide in paediatric respiratory disorders: novel interventions to address associated vascular phenomena? 61
27215618 2016
45
Association of Hospital Structure and Complications With Mortality After Pediatric Extracorporeal Membrane Oxygenation. 61
27099971 2016
46
High-frequency ventilation for non-invasive respiratory support of neonates. 61
26906338 2016
47
Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization. 61
27188440 2016
48
Prenatal Diagnosis of Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins. 61
26703872 2016
49
Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. 61
26252542 2016
50
Successful primary use of VVDL+V ECMO with cephalic drain in neonatal respiratory failure. 61
26562372 2016

Variations for Neonatal Respiratory Failure

Expression for Neonatal Respiratory Failure

Search GEO for disease gene expression data for Neonatal Respiratory Failure.

Pathways for Neonatal Respiratory Failure

Pathways related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.43 SFTPD SFTPC SFTPB SFTPA2
2
Show member pathways
11.1 SFTPD SFTPA2 SCGB1A1
3 10.97 NKX2-1 FOXF1
4
Show member pathways
10.65 SFTPD SFTPC SFTPB SFTPA2
5
Show member pathways
10.65 SFTPD SFTPC SFTPB SFTPA2 ABCA3

GO Terms for Neonatal Respiratory Failure

Cellular components related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.88 SFTPD SFTPC SFTPB SFTPA2 SCGB1A1 ABCA3
2 rough endoplasmic reticulum GO:0005791 9.5 SFTPD SFTPA2 SCGB1A1
3 multivesicular body GO:0005771 9.43 SFTPD SFTPB SFTPA2
4 multivesicular body lumen GO:0097486 9.37 SFTPC SFTPB
5 lamellar body GO:0042599 9.33 SFTPC SFTPB SFTPA2
6 alveolar lamellar body GO:0097208 9.13 SFTPC SFTPB ABCA3
7 clathrin-coated endocytic vesicle GO:0045334 8.92 SFTPD SFTPC SFTPB SFTPA2

Biological processes related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.58 SFTPB NKX2-1 FOXF1
2 lung development GO:0030324 9.56 TBX4 NKX2-1 FOXF1 ABCA3
3 cellular protein metabolic process GO:0044267 9.55 SFTPD SFTPC SFTPB SFTPA2 ABCA3
4 toll-like receptor signaling pathway GO:0002224 9.48 SFTPD SFTPA2
5 negative regulation of T cell proliferation GO:0042130 9.46 SFTPD SCGB1A1
6 lung alveolus development GO:0048286 9.43 SFTPD FOXF1
7 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 NKX2-1 FOXF1
8 phospholipid homeostasis GO:0055091 9.32 RCN3 ABCA3
9 surfactant homeostasis GO:0043129 9.13 SFTPD RCN3 ABCA3
10 respiratory gaseous exchange GO:0007585 8.92 SFTPD SFTPC SFTPB SFTPA2

Molecular functions related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 8.92 TRPS1 TBX4 NKX2-1 FOXF1

Sources for Neonatal Respiratory Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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