MCID: NNT004
MIFTS: 33

Neonatal Respiratory Failure

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Neonatal Respiratory Failure

MalaCards integrated aliases for Neonatal Respiratory Failure:

Name: Neonatal Respiratory Failure 12 15 74
Respiratory Failure of Newborn 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11161
ICD9CM 36 770.84
SNOMED-CT 69 95619009
ICD10 34 P28.5
UMLS 74 C0521648

Summaries for Neonatal Respiratory Failure

MalaCards based summary : Neonatal Respiratory Failure, also known as respiratory failure of newborn, is related to respiratory failure and interstitial lung disease. An important gene associated with Neonatal Respiratory Failure is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and Surfactant metabolism. Affiliated tissues include lung, brain and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neonatal Respiratory Failure

Diseases related to Neonatal Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 respiratory failure 31.2 SFTPB SFTPC
2 interstitial lung disease 29.3 ABCA3 SFTPB SFTPC
3 lung disease 29.3 ABCA3 SFTPB SFTPC
4 desquamative interstitial pneumonia 10.1 ABCA3 SFTPC
5 diffuse pulmonary fibrosis 10.1 ABCA3 SFTPC
6 pneumonia 10.0 SFTPB SFTPC
7 pulmonary immaturity 10.0 SFTPB SFTPC
8 diaphragm disease 10.0 SFTPB SFTPC
9 acute respiratory distress syndrome 9.9 SFTPB SFTPC
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
11 sensorineural hearing loss 9.9
12 pulmonary alveolar proteinosis 9.9 SFTPB SFTPC
13 surfactant dysfunction 9.8 ABCA3 SFTPB SFTPC
14 adult respiratory distress syndrome 9.8 SFTPB SFTPC
15 nonspecific interstitial pneumonia 9.8 FOXF1 SFTPC
16 respiratory distress syndrome in premature infants 9.8 ABCA3 SFTPB SFTPC
17 newborn respiratory distress syndrome 9.8 ABCA3 SFTPB SFTPC
18 pulmonary fibrosis, idiopathic 9.8 ABCA3 SFTPB SFTPC
19 rhizomelic chondrodysplasia punctata, type 1 9.8
20 chondrodysplasia punctata syndrome 9.8
21 bronchopulmonary dysplasia 9.8
22 congenital hypothyroidism 9.8
23 chlamydia 9.8
24 gestational diabetes 9.8
25 hypothyroidism 9.8
26 rhizomelic chondrodysplasia punctata 9.8
27 myotonic dystrophy 9.8
28 alveolar capillary dysplasia 9.8
29 diffuse intrinsic pontine glioma 9.8
30 glioma 9.8
31 myotonia atrophica 9.8
32 diaphragmatic hernia, congenital 9.7 SFTPB SFTPC

Graphical network of the top 20 diseases related to Neonatal Respiratory Failure:



Diseases related to Neonatal Respiratory Failure

Symptoms & Phenotypes for Neonatal Respiratory Failure

GenomeRNAi Phenotypes related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.23 TBX4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.23 SFTPB TBX4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.23 SFTPB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.23 SFTPB
5 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.23 TBX4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.23 SFTPB
7 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.23 SFTPB

MGI Mouse Phenotypes related to Neonatal Respiratory Failure:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ABCA3 FOXF1 LMOD3 SFTPC TBX4
2 respiratory system MP:0005388 8.92 ABCA3 FOXF1 SFTPB SFTPC

Drugs & Therapeutics for Neonatal Respiratory Failure

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Bi-Level Positive Airway Pressure (BIPAP) Versus Non Invasive Positive Pressure Ventilation (NIPPV) for Neonatal Respiratory Failure Unknown status NCT01318824 Phase 3
2 Use of Orotracheal Continuous Positive Airway Pressure (CPAP) in Newborns With Respiratory Failure Unknown status NCT01379820 Phase 2, Phase 3
3 Non Invasive Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants. Unknown status NCT01778829 Phase 3
4 Endotracheal Tube Placement in Neonatal Intubation Completed NCT03591835 Not Applicable
5 Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns Completed NCT01531010 Not Applicable
6 Trial of Weaning by Synchronized Ventilation Completed NCT01376544 Not Applicable
7 Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children Completed NCT00005683
8 Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room Recruiting NCT03166826
9 Validation of a Novel Oxygen Consumption Measurement Technique in Neonates Recruiting NCT03154112
10 Hypothermia During ECMO to Decrease Brain Injury Withdrawn NCT01675388 Not Applicable

Search NIH Clinical Center for Neonatal Respiratory Failure

Genetic Tests for Neonatal Respiratory Failure

Anatomical Context for Neonatal Respiratory Failure

MalaCards organs/tissues related to Neonatal Respiratory Failure:

42
Lung, Brain, Kidney

Publications for Neonatal Respiratory Failure

Articles related to Neonatal Respiratory Failure:

(show top 50) (show all 88)
# Title Authors Year
1
Observation of curative effect of nasal continuous positive airway pressure combined with high-dose ambroxol for neonatal respiratory failure. ( 30203757 )
2018
2
Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. ( 29972353 )
2018
3
Admission volume is associated with mortality of neonatal respiratory failure in emerging neonatal intensive care units. ( 29385861 )
2018
4
Double aortic arch presenting as neonatal respiratory failure in the delivery room. ( 29248031 )
2018
5
The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate. ( 28808495 )
2017
6
Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. ( 28504997 )
2017
7
Neonatal respiratory failure due to ABCA3 deficiency. ( 28038995 )
2017
8
Venoarterial Extracorporeal Life Support for Neonatal Respiratory Failure: Indications and Impact on Mortality. ( 27984316 )
2017
9
Mortality of neonatal respiratory failure from Chinese northwest NICU network. ( 27651118 )
2017
10
Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma. ( 28116951 )
2017
11
Successful primary use of VVDL+V ECMO with cephalic drain in neonatal respiratory failure. ( 26562372 )
2016
12
Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. ( 26252542 )
2016
13
Effect of Change of Mechanical Ventilation Position on the Treatment of Neonatal Respiratory Failure. ( 25647746 )
2015
14
[A population-based epidemiological survey of neonatal respiratory failure in Huai'an City of Jiangsu Province, in 2010]. ( 25406560 )
2014
15
Venoarterial versus venovenous ECMO for neonatal respiratory failure. ( 24580762 )
2014
16
Exercise capacity, daily activity, and severity of fatigue in term born young adults after neonatal respiratory failure. ( 22724460 )
2014
17
Comparison of High Frequency Positive Pressure Mechanical Ventilation (HFPPV) With Conventional Method in the Treatment of Neonatal Respiratory Failure. ( 23983995 )
2013
18
Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p.Cys121Gly mutation with hydroxychloroquine. ( 23719253 )
2013
19
The pulmonary circulation in neonatal respiratory failure. ( 22954275 )
2012
20
Morbidity and mortality of neonatal respiratory failure in China: surfactant treatment in very immature infants. ( 22331337 )
2012
21
Fatal neonatal respiratory failure in an infant with congenital hypothyroidism due to haploinsufficiency of the NKX2-1 gene: alteration of pulmonary surfactant homeostasis. ( 20584796 )
2011
22
Acute management of neonatal respiratory failure due to crossed ectopic obstructed megaureter in a duplicated pelvic kidney. ( 21050823 )
2011
23
Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China. ( 21150226 )
2011
24
Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology. ( 22052861 )
2011
25
Gestational diabetes: a strong independent risk factor for severe neonatal respiratory failure after 34 weeks. ( 21170541 )
2011
26
Extracorporeal membrane oxygenation and term neonatal respiratory failure deaths in the United Kingdom compared with the United States: 1999 to 2005. ( 19593243 )
2010
27
Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. ( 20118944 )
2010
28
Extracorporeal membrane oxygenation for neonatal respiratory failure. ( 19712500 )
2009
29
Extracorporeal membrane oxygenation for the treatment of neonatal respiratory failure. ( 19713207 )
2009
30
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. ( 18450855 )
2008
31
Clinical correlations and pulmonary function at 8 years of age after severe neonatal respiratory failure. ( 17654569 )
2007
32
Neonatal respiratory failure associated with mutation in the surfactant protein C gene. ( 16355106 )
2006
33
Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure. ( 16449030 )
2006
34
Continuous negative extrathoracic pressure (CNEP) in neonatal respiratory failure: correction. ( 16740893 )
2006
35
ABCA3 deficiency: neonatal respiratory failure and interstitial lung disease. ( 17142158 )
2006
36
ECMO for neonatal respiratory failure. ( 15921148 )
2005
37
[Neonatal respiratory failure associated with mutation in the surfactant protein C gene]. ( 15737281 )
2005
38
Venovenous extracorporeal membrane oxygenation in neonatal respiratory failure: does routine, cephalad jugular drainage improve outcome? ( 15136997 )
2004
39
Acinar dysplasia: a rare cause of neonatal respiratory failure. ( 15174801 )
2004
40
Long-term pulmonary sequelae in children who were treated with extracorporeal membrane oxygenation for neonatal respiratory failure. ( 15520110 )
2004
41
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the US. ( 14654622 )
2003
42
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. ( 14654609 )
2003
43
Late-onset, progressive sensorineural hearing loss after severe neonatal respiratory failure. ( 11981395 )
2002
44
Neonatal respiratory failure. ( 12011671 )
2002
45
Acute neonatal respiratory failure and Chlamydia trachomatis. ( 11287694 )
2001
46
Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. ( 11673202 )
2001
47
Experimental neonatal respiratory failure induced by lysophosphatidylcholine: effect of surfactant treatment. ( 9931201 )
1999
48
Intratracheal pulmonary ventilation in neonatal respiratory failure. ( 9934880 )
1999
49
State of the art. Neonatal respiratory failure. ( 10855113 )
1999
50
Which interventions for neonatal respiratory failure are effective? ( 9575272 )
1998

Variations for Neonatal Respiratory Failure

Expression for Neonatal Respiratory Failure

Search GEO for disease gene expression data for Neonatal Respiratory Failure.

Pathways for Neonatal Respiratory Failure

Pathways related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 SFTPB SFTPC
2
Show member pathways
10.43 ABCA3 SFTPB SFTPC
3
Show member pathways
10.35 SFTPB SFTPC

GO Terms for Neonatal Respiratory Failure

Cellular components related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-coated endocytic vesicle GO:0045334 9.26 SFTPB SFTPC
2 lamellar body GO:0042599 9.16 SFTPB SFTPC
3 multivesicular body lumen GO:0097486 8.96 SFTPB SFTPC
4 alveolar lamellar body GO:0097208 8.62 ABCA3 SFTPB

Biological processes related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.26 FOXF1 SFTPB
2 lung development GO:0030324 9.16 FOXF1 TBX4
3 respiratory gaseous exchange GO:0007585 8.96 SFTPB SFTPC
4 cellular protein metabolic process GO:0044267 8.8 ABCA3 SFTPB SFTPC

Sources for Neonatal Respiratory Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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