NIS
MCID: NNT024
MIFTS: 31

Neonatal Stroke (NIS)

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Neonatal Stroke

MalaCards integrated aliases for Neonatal Stroke:

Name: Neonatal Stroke 20 37 70
Perinatal Arterial Ischemic Stroke 20
Perinatal Ischemic Stroke 20
Neonatal Ischemic Stroke 20
Perinatal Stroke 20
Nis 20

Classifications:



External Ids:

UMLS 70 C1299567

Summaries for Neonatal Stroke

MalaCards based summary : Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to stroke, ischemic and moyamoya disease 1. An important gene associated with Neonatal Stroke is ACTA2 (Actin Alpha 2, Smooth Muscle), and among its related pathways/superpathways is Apelin signaling pathway. The drugs Darbepoetin alfa and Passionflower have been mentioned in the context of this disorder. Affiliated tissues include Bone, thyroid and bone marrow.

Wikipedia : 73 Neonatal stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Related Diseases for Neonatal Stroke

Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 stroke, ischemic 30.1 SERPINE1 MTHFR AQP4
2 moyamoya disease 1 29.6 MTHFR ACTA2
3 antiphospholipid syndrome 29.6 SERPINE1 MTHFR
4 protein s deficiency 29.5 PROC MTHFR
5 thrombophilia due to activated protein c resistance 29.5 SERPINE1 MTHFR
6 patent foramen ovale 29.3 SERPINE1 MTHFR
7 cerebrovascular disease 29.2 SERPINE1 MTHFR ACTA2
8 thrombophilia 29.1 SERPINE1 PROC MTHFR
9 thrombosis 28.9 SERPINE1 PROC MTHFR
10 protein c deficiency 28.9 SERPINE1 PROC MTHFR
11 thrombophilia due to thrombin defect 28.9 SERPINE1 PROC MTHFR
12 pulmonary embolism 28.9 SERPINE1 PROC MTHFR
13 thrombocytopenia 28.8 SERPINE1 PROC MTHFR
14 cortical blindness 11.2
15 thyroid carcinoma 10.4
16 cerebral artery occlusion 10.4
17 hypothyroidism 10.4
18 cerebral palsy 10.3
19 congenital hypothyroidism 10.3
20 attention deficit-hyperactivity disorder 10.2
21 west syndrome 10.2
22 gestational diabetes 10.2
23 focal epilepsy 10.2
24 goiter 10.2
25 cerebral sinovenous thrombosis 10.1
26 thyroid gland disease 10.1
27 hypoxia 10.1
28 asplenia, isolated congenital 10.1
29 quadriplegia 10.1
30 encephalomalacia 10.1
31 bilirubin metabolic disorder 10.1
32 carotid artery occlusion 10.1
33 vasculitis 10.1
34 graves' disease 10.1
35 polyneuropathy 10.0
36 thyroiditis 10.0
37 measles 10.0
38 neuroma 10.0 AQP4 ACTA2
39 central retinal artery occlusion 10.0 MTHFR ACTA2
40 branch retinal artery occlusion 10.0 MTHFR AQP4
41 encephalopathy 10.0
42 thyroid cancer, nonmedullary, 1 10.0
43 guillain-barre syndrome 10.0
44 appendicitis 10.0
45 stomatitis 10.0
46 compartment syndrome 10.0
47 learning disability 10.0
48 amaurosis fugax 10.0 SERPINE1 MTHFR
49 livedoid vasculitis 10.0 SERPINE1 MTHFR
50 cyanosis, transient neonatal 9.9

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to Neonatal Stroke

Symptoms & Phenotypes for Neonatal Stroke

Drugs & Therapeutics for Neonatal Stroke

Drugs for Neonatal Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2, 11096-26-7
2 Passionflower Phase 1, Phase 2
3 Hematinics Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Modulation of Brain Plasticity After Perinatal Stroke: The PLASTIC CHAMPS Trial Unknown status NCT01189058 Phase 2, Phase 3
2 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Unknown status NCT03216837 Phase 2, Phase 3
3 Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE) Recruiting NCT03910075 Phase 3
4 Enhancing Developmental Motor Plasticity After Perinatal Stroke With Transcranial Direct Current Stimulation Completed NCT02170285 Phase 2
5 Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) Recruiting NCT03356821 Phase 1, Phase 2
6 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
7 Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Suspended NCT02460484 Phase 1, Phase 2
8 Early Intervention in Infants With Perinatal Stroke : CIMT Versus HABIT : a Randomized Clinical Trial Unknown status NCT02720432
9 Protein Supplementation in Infants With Brain Injury Completed NCT01936246
10 Intensive Motor Training After Perinatal Stroke to Enhance Walking Completed NCT01773369
11 Perinatal Stroke: Understanding Brain Reorganization Through Infant Neuroimaging and Neuromodulation Recruiting NCT02743728
12 Parent Therapist Partnership to Provide Early, Intensive Exercise to Enhance Walking Outcomes in Children With Perinatal Stroke Recruiting NCT03672864
13 Functional Electrical Stimulation to Improve Upper Extremity Function in Young Children With Perinatal Stroke: A Proof of Concept Study Active, not recruiting NCT02975180

Search NIH Clinical Center for Neonatal Stroke

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem, bone marrow-derived cells for ischemic and neonatal stroke
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285

Genetic Tests for Neonatal Stroke

Anatomical Context for Neonatal Stroke

MalaCards organs/tissues related to Neonatal Stroke:

40
Thyroid, Bone Marrow, Brain, Breast, Heart, Liver, Cortex
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Neonatal Stroke

Articles related to Neonatal Stroke:

(show top 50) (show all 535)
# Title Authors PMID Year
1
Goals of children with unilateral cerebral palsy in a brain stimulation arm rehabilitation trial. 61
33368181 2021
2
High-Dose Prednisolone for Treatment of Infantile Spasms After Presumed Perinatal Stroke. 61
33538457 2021
3
Perinatal Stroke: A Practical Approach to Diagnosis and Management. 61
33649089 2021
4
Fetal brain small vessel disease 1 caused by a novel mutation in the COL4A1 gene. 61
33057775 2021
5
Imaging Developmental and Interventional Plasticity Following Perinatal Stroke. 61
32727626 2021
6
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke. 61
33654279 2021
7
Head circumference trajectory in children with perinatal stroke. 61
33683972 2021
8
Paediatric ischaemic stroke is a valid diagnosis in the Swedish National Patient Register. 61
33539576 2021
9
Constraint-induced movement therapy promotes motor recovery after neonatal stroke in the absence of neural precursor activation. 61
33010080 2021
10
The clinical utility of the behavior rating inventory of executive function in preschool children with a history of perinatal stroke. 61
33535801 2021
11
Protocol for a cost-utility analysis of neurostimulation and intensive camp-based therapy for children with perinatal stroke and hemiparesis based on a multicentre clinical trial. 61
33468454 2021
12
Evaluating transcranial magnetic stimulation (TMS) induced electric fields in pediatric stroke. 61
33516935 2021
13
Longitudinal Stability of Spatial Inattention in Children With Perinatal Stroke. 61
33714923 2021
14
Executive behavior and functional abilities in children with perinatal stroke and the associated caregiver impact. 61
32718269 2021
15
Automated quantification of spike-wave activity may be used to predict the development of electrical status epilepticus in sleep (ESES) in children with perinatal stroke. 61
33278667 2021
16
Clinico-Epidemiological Profile, Etiology, and Imaging in Neonatal Stroke: An Observational Study from Eastern India. 61
33642272 2021
17
Enhanced Mesenchymal Stromal Cells or Erythropoietin Provide Long-Term Functional Benefit After Neonatal Stroke. 61
33349013 2021
18
Cardiovascular Effects of Transcranial Direct Current Stimulation and Bimanual Training in Children With Cerebral Palsy. 61
33337767 2021
19
Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries. 61
33451166 2021
20
Intervention experiences among children with congenital and neonatal conditions impacting brain development: patterns of service utilization, barriers and future directions. 61
33438483 2021
21
Neuroimaging Perspectives of Perinatal Arterial Ischemic Stroke. 61
33038575 2020
22
Parental and professional opinion regarding outcome after neonatal stroke. 61
32654128 2020
23
3D Motion Capture May Detect Spatiotemporal Changes in Pre-Reaching Upper Extremity Movements with and without a Real-Time Constraint Condition in Infants with Perinatal Stroke and Cerebral Palsy: A Longitudinal Case Series. 61
33352727 2020
24
Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains. 61
33318553 2020
25
Motor outcome after perinatal stroke and early prediction of unilateral spastic cerebral palsy. 61
32988734 2020
26
Targeted re-sequencing in pediatric and perinatal stroke. 61
32818659 2020
27
Population Based Birth Prevalence of Disease-Specific Perinatal Stroke. 61
33115795 2020
28
Developmental neuroplasticity of the white matter connectome in children with perinatal stroke. 61
32887781 2020
29
Developmental Remodelling of the Motor Cortex in Hemiparetic Children With Perinatal Stroke. 61
32911261 2020
30
Transdiagnostic feasibility trial of internet-based parenting intervention to reduce child behavioural difficulties associated with congenital and neonatal neurodevelopmental risk: introducing I-InTERACT-North. 61
33028141 2020
31
Unilateral Terson-Like Syndrome in a Patient With a Perinatal Ischemic Stroke. 61
33104227 2020
32
Methylprednisolone Reduces Persistent Post-ischemic Inflammation in a Rat Hypoxia-Ischemia Model of Perinatal Stroke. 61
32140998 2020
33
The Role of the Placenta in Perinatal Stroke: A Systematic Review. 61
32516012 2020
34
Impact on rehabilitation programs during COVID-19 containment for children with pediatric and perinatal stroke. 61
32519529 2020
35
Hemispherotomy for Epilepsy: The Procedure Evolution and Outcome. 61
32998781 2020
36
Parent experiences and developmental outcomes following neonatal stroke. 61
32924802 2020
37
Association of neonatal inflammatory markers and perinatal stroke subtypes. 61
32727836 2020
38
Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke. 61
32923636 2020
39
Robotic assessment of rapid motor decision making in children with perinatal stroke. 61
32664980 2020
40
Rituximab, MS, and pregnancy. 61
32358226 2020
41
Predicting Recovery and Outcome after Pediatric Stroke: Results from the International Pediatric Stroke Study. 61
32215969 2020
42
Congenital hypothyroidism, cardiac defects, and pancreatic agenesis in an infant with GATA6 mutation. 61
32207556 2020
43
Neonatal Stroke and TLR1/2 Ligand Recruit Myeloid Cells through the Choroid Plexus in a CX3CR1-CCR2- and Context-Specific Manner. 61
32269105 2020
44
Safety and tolerability of transcranial magnetic and direct current stimulation in children: Prospective single center evidence from 3.5 million stimulations. 61
32289678 2020
45
Perinatal inflammation and placental programming of neonatal stroke. 61
31591709 2020
46
Differences in coordination and timing of pre-reaching upper extremity movements may be an indicator of cerebral palsy in infants with stroke: A preliminary investigation. 61
32007826 2020
47
Unilateral Abducens Nerve Palsy Following Perinatal Stroke of the Middle Cerebral Artery. 61
32176807 2020
48
Enhancing Stroke Recovery Across the Life Span With Noninvasive Neurostimulation. 61
32142023 2020
49
Cognitive resilience following paediatric stroke: Biological and environmental predictors. 61
31866101 2020
50
Epidemiology of neonatal stroke: A population-based study. 61
33390736 2020

Variations for Neonatal Stroke

Expression for Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for Neonatal Stroke

Pathways related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.76 SERPINE1 ACTA2

GO Terms for Neonatal Stroke

Cellular components related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 SERPINE1 PROC CTF1 ACTA2

Biological processes related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood coagulation GO:0030195 8.62 SERPINE1 PROC

Sources for Neonatal Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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