Aliases & Classifications for Neonatal Stroke

MalaCards integrated aliases for Neonatal Stroke:

Name: Neonatal Stroke 38 53 73
Perinatal Arterial Ischemic Stroke 53
Perinatal Ischemic Stroke 53
Neonatal Ischemic Stroke 53
Perinatal Stroke 53
Nis 53

Classifications:



External Ids:

UMLS 73 C1299567

Summaries for Neonatal Stroke

CDC : 3 NIOSH Pocket Guide to Chemical Hazards Exposure limits, Respirator Recommendations, First Aid, more... The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards based summary : Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to protein c deficiency and thrombophilia. An important gene associated with Neonatal Stroke is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Aspirin and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Related Diseases for Neonatal Stroke

Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 protein c deficiency 28.5 MTHFR PROC
2 thrombophilia 28.1 MTHFR PROC SERPINE1
3 thrombosis 28.1 MTHFR PROC SERPINE1
4 neutropenia, nonimmune chronic idiopathic, of adults 11.6
5 cortical blindness 11.1
6 extrinsic allergic alveolitis 10.9
7 idiopathic neutropenia 10.9
8 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 10.9
9 thyroiditis 10.3
10 thyroid cancer 10.2
11 hypothyroidism 10.1
12 breast cancer 10.0
13 inferior vena cava interruption 10.0 MTHFR SERPINE1
14 amaurosis fugax 10.0 MTHFR SERPINE1
15 livedoid vasculopathy 10.0 MTHFR SERPINE1
16 cerebritis 10.0
17 cryptogenic cirrhosis 10.0 MTHFR SERPINE1
18 prostate cancer 10.0
19 prostatitis 10.0
20 retinal artery occlusion 10.0 MTHFR SERPINE1
21 buerger disease 10.0 MTHFR SERPINE1
22 thrombophlebitis 9.9 MTHFR SERPINE1
23 congenital hypothyroidism 9.9
24 neonatal hypothyroidism 9.9
25 lemierre's syndrome 9.9 MTHFR SERPINE1
26 portal vein thrombosis 9.9 MTHFR SERPINE1
27 hepatic vascular disease 9.9 MTHFR SERPINE1
28 hypoxia 9.9
29 neutrophil migration 9.8
30 goiter 9.8
31 melanoma 9.8
32 retinal vein occlusion 9.8 MTHFR SERPINE1
33 ischemia 9.8
34 neuronitis 9.8
35 thrombophilia due to activated protein c resistance 9.8 MTHFR SERPINE1
36 osteonecrosis 9.8 MTHFR SERPINE1
37 cerebral palsy 9.8
38 pulmonary embolism 9.7 MTHFR SERPINE1
39 meningococcemia 9.7 PROC SERPINE1
40 cerebral artery occlusion 9.7
41 encephalopathy 9.7
42 neonatal hypoxic and ischemic brain injury 9.7
43 arteries, anomalies of 9.7 MTHFR SERPINE1
44 blood protein disease 9.6 MTHFR PROC
45 down syndrome 9.6
46 moyamoya disease 1 9.6
47 diamond-blackfan anemia 9.6
48 marantic endocarditis 9.6 MTHFR PROC
49 aging 9.5
50 brain injury 9.5

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to Neonatal Stroke

Symptoms & Phenotypes for Neonatal Stroke

MGI Mouse Phenotypes related to Neonatal Stroke:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 AQP4 CTF1 MTHFR PROC SERPINE1
2 homeostasis/metabolism MP:0005376 9.02 AQP4 CTF1 MTHFR PROC SERPINE1

Drugs & Therapeutics for Neonatal Stroke

Drugs for Neonatal Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4 Prednisolone acetate Phase 3
5 Analgesics Phase 3
6 glucocorticoids Phase 3
7 Fibrinolytic Agents Phase 3
8 Methylprednisolone acetate Phase 3
9 Methylprednisolone Hemisuccinate Phase 3
10 Gastrointestinal Agents Phase 3
11 Neuroprotective Agents Phase 3
12 Cyclooxygenase Inhibitors Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Hormone Antagonists Phase 3
15 Hormones Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Platelet Aggregation Inhibitors Phase 3
19 Prednisolone hemisuccinate Phase 3
20 Prednisolone phosphate Phase 3
21 Antiemetics Phase 3
22 Protective Agents Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Antipyretics Phase 3
25 Anti-Inflammatory Agents, Non-Steroidal Phase 3
26 Antirheumatic Agents Phase 3
27 Autonomic Agents Phase 3
28 Antineoplastic Agents, Hormonal Phase 3
29
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
30 Hematinics Phase 2
31 Passionflower Nutraceutical Phase 1, Phase 2
32
Phenobarbital Approved, Investigational Phase 1 50-06-6 4763
33
Bumetanide Approved Phase 1 28395-03-1 2471
34 diuretics Phase 1
35 Central Nervous System Depressants Phase 1
36 GABA Agents Phase 1
37 GABA Modulators Phase 1
38 Natriuretic Agents Phase 1
39 Sodium Potassium Chloride Symporter Inhibitors Phase 1
40 Neurotransmitter Agents Phase 1
41 Cytochrome P-450 CYP3A Inducers Phase 1
42 Hypnotics and Sedatives Phase 1
43 Excitatory Amino Acid Antagonists Phase 1
44 Excitatory Amino Acids Phase 1
45 Anticonvulsants Phase 1
46
Thrombin Approved, Investigational
47
Menthol Approved Not Applicable 2216-51-5 16666
48 Pharmaceutical Solutions

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
2 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
3 Paediatric Arteriopathy Steroid Aspirin Project Not yet recruiting NCT03249844 Phase 3 Methylprednisolone + prednisolone
4 Enhancing Motor Plasticity After Perinatal Stroke Using tDCS Completed NCT02170285 Phase 2
5 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
6 Perinatal Arterial Stroke Treated With Stromal Cells Intranasally Not yet recruiting NCT03356821 Phase 1, Phase 2
7 Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke Suspended NCT02460484 Phase 1, Phase 2
8 Transcranial Magnetic Stimulation in Children With Stroke Completed NCT01637129 Phase 1
9 Pilot Study of Bumetanide for Newborn Seizures Active, not recruiting NCT00830531 Phase 1 Bumetanide;Normal Saline as Placebo
10 Umbilical Cord Blood in the Treatment of Stroke in Children. Withdrawn NCT01700166 Phase 1
11 Early Determinants of Multidimensional Outcome at School Age After Neonatal Arterial Ischemic Stroke Completed NCT02511249
12 Protein Supplementation in Infants With Brain Injury Completed NCT01936246 Not Applicable
13 Study of Abnormal Blood Clotting in Children With Stroke Completed NCT00001927
14 Perinatal Stroke: Understanding Brain Reorganization Recruiting NCT02743728 Not Applicable
15 Intensive Motor Training After Perinatal Stroke to Enhance Walking Recruiting NCT01773369 Not Applicable
16 Early Intervention in Infants With Perinatal Stroke Recruiting NCT02720432 Not Applicable
17 National Egyptian Network Pediatric Stroke and Hemiplegia Registry Recruiting NCT02129491
18 Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk Recruiting NCT03246243
19 FES in Young Children With Perinatal Stroke Not yet recruiting NCT02975180 Not Applicable

Search NIH Clinical Center for Neonatal Stroke

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285

Genetic Tests for Neonatal Stroke

Anatomical Context for Neonatal Stroke

MalaCards organs/tissues related to Neonatal Stroke:

41
Brain, Bone, Bone Marrow, Endothelial, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Neonatal Stroke

Articles related to Neonatal Stroke:

(show top 50) (show all 99)
# Title Authors Year
1
Dose-Dependent Effect of Intravenous Administration of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Neonatal Stroke Mice. ( 29568282 )
2018
2
Manual dexterity, but not cerebral palsy, predicts cognitive functioning after neonatal stroke. ( 29624666 )
2018
3
Manual dexterity and cognitive outcome after neonatal stroke. ( 29671877 )
2018
4
Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. ( 29852289 )
2018
5
Placental Pathology in Neonatal Stroke: A Retrospective Case-Control Study. ( 29397159 )
2018
6
Developmental conduction aphasia after neonatal stroke. ( 29572915 )
2018
7
Neonatal stroke and haematuria: Questions. ( 28717936 )
2017
8
Pathways for Neuroimaging of Neonatal Stroke. ( 28262550 )
2017
9
Neonatal stroke and haematuria: Answers. ( 28717939 )
2017
10
Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia. ( 29278365 )
2017
11
Role of seizure in neonatal stroke. ( 28562317 )
2017
12
Variability in Clinical Presentation of Neonatal Stroke: Report of Four Cases. ( 28194288 )
2017
13
Is there an excess of left-handedness after neonatal stroke? ( 28893386 )
2017
14
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. ( 28518065 )
2017
15
In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. ( 26782250 )
2016
16
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
17
Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. ( 27142685 )
2016
18
Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics? ( 27165960 )
2016
19
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency. ( 26250584 )
2015
20
Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. ( 25647744 )
2015
21
A Primer for Nurses on Perinatal/Neonatal Stroke. ( 26264800 )
2015
22
Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. ( 26223273 )
2015
23
Long term motor function after neonatal stroke: Lesion localization above all. ( 26512551 )
2015
24
Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke. ( 24444827 )
2014
25
Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. ( 24428836 )
2014
26
Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study. ( 24503061 )
2014
27
Are we considering neonatal stroke early enough in our differential diagnosis? ( 25468618 )
2014
28
Stem cells for neonatal stroke- the future is here. ( 25120432 )
2014
29
Barrier mechanisms in neonatal stroke. ( 25426016 )
2014
30
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. ( 23391775 )
2013
31
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. ( 22512322 )
2013
32
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. ( 23291519 )
2013
33
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. ( 23539530 )
2013
34
A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model. ( 23651512 )
2013
35
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. ( 23830950 )
2013
36
Quantification of white matter injury following neonatal stroke with serial DTI. ( 23478641 )
2013
37
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation. ( 22752479 )
2013
38
Do early MRI signals predict lesion size in a neonatal stroke rat model? ( 22555584 )
2013
39
Corticospinal tract integrity and motor function following neonatal stroke: a case study. ( 22776078 )
2012
40
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation. ( 23162020 )
2012
41
Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. ( 22285309 )
2012
42
Genetic deletion of CD36 enhances injury after acute neonatal stroke. ( 23280844 )
2012
43
Neonatal stroke. ( 22933099 )
2012
44
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. ( 22787045 )
2012
45
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. ( 22949477 )
2012
46
Neonatal stroke. ( 21852256 )
2011
47
Early continuous video electroencephalography in neonatal stroke. ( 21087242 )
2011
48
Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. ( 21670390 )
2011
49
Placental pathology in neonatal stroke. ( 21339263 )
2011
50
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. ( 20856166 )
2011

Variations for Neonatal Stroke

Expression for Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for Neonatal Stroke

GO Terms for Neonatal Stroke

Biological processes related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood coagulation GO:0030195 8.62 PROC SERPINE1

Sources for Neonatal Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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