NIS
MCID: NNT024
MIFTS: 38

Neonatal Stroke (NIS)

Categories: Rare diseases

Aliases & Classifications for Neonatal Stroke

MalaCards integrated aliases for Neonatal Stroke:

Name: Neonatal Stroke 38 53 73
Perinatal Arterial Ischemic Stroke 53
Perinatal Ischemic Stroke 53
Neonatal Ischemic Stroke 53
Perinatal Stroke 53
Nis 53

Classifications:



External Ids:

UMLS 73 C1299567

Summaries for Neonatal Stroke

CDC : 3 CAS#: 7440-02-0

MalaCards based summary : Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to thrombophilia and thrombosis. An important gene associated with Neonatal Stroke is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Selenium Micronutrient Network and Formation of Fibrin Clot (Clotting Cascade). The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Related Diseases for Neonatal Stroke

Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 29.3 MTHFR PROC SERPINE1
2 thrombosis 29.2 MTHFR PROC SERPINE1
3 protein c deficiency 29.2 MTHFR PROC
4 stroke, ischemic 29.2 AQP4 MTHFR SERPINE1
5 neutropenia, nonimmune chronic idiopathic, of adults 11.7
6 meniere disease 11.4
7 cortical blindness 11.3
8 fanconi syndrome 11.1
9 extrinsic allergic alveolitis 11.1
10 nickel allergic asthma 11.0
11 nickel allergic contact dermatitis 11.0
12 idiopathic neutropenia 11.0
13 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 11.0
14 thyroid cancer 10.4
15 rapidly involuting congenital hemangioma 10.4
16 segmental odontomaxillary dysplasia 10.3
17 pemphigus foliaceus 10.3
18 hypothyroidism 10.2
19 isolated optic neuritis 10.2
20 primary orthostatic tremor 10.2
21 breast cancer 10.1
22 adamantinoma of long bones 10.1
23 prostate cancer 10.1
24 horns in sheep 10.1
25 congenital hypothyroidism 10.1
26 neonatal hypothyroidism 10.1
27 inferior vena cava interruption 10.0 MTHFR SERPINE1
28 retinoblastoma 10.0
29 blood group--swann system 10.0
30 acute insulin response 10.0
31 amaurosis fugax 10.0 MTHFR SERPINE1
32 cryptogenic cirrhosis 10.0 MTHFR SERPINE1
33 livedoid vasculitis 10.0 MTHFR SERPINE1
34 thrombophlebitis 10.0 MTHFR SERPINE1
35 buerger disease 10.0 MTHFR SERPINE1
36 lemierre's syndrome 10.0 MTHFR SERPINE1
37 carotid artery occlusion 10.0
38 cerebral sinovenous thrombosis 10.0
39 hypoxia 10.0
40 retinal artery occlusion 10.0 MTHFR SERPINE1
41 portal vein thrombosis 10.0 MTHFR SERPINE1
42 hepatic vascular disease 10.0 MTHFR SERPINE1
43 retinal vein occlusion 9.9 MTHFR SERPINE1
44 thrombophilia due to activated protein c resistance 9.9 MTHFR SERPINE1
45 osteonecrosis 9.9 MTHFR SERPINE1
46 ischemia 9.9
47 neutrophil migration 9.9
48 triiodothyronine receptor auxiliary protein 9.9
49 pancreatic ductal adenocarcinoma 9.9
50 spinal muscular atrophy 9.9

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to Neonatal Stroke

Symptoms & Phenotypes for Neonatal Stroke

MGI Mouse Phenotypes related to Neonatal Stroke:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 AQP4 CTF1 MTHFR PROC SERPINE1
2 homeostasis/metabolism MP:0005376 9.02 AQP4 CTF1 MTHFR PROC SERPINE1

Drugs & Therapeutics for Neonatal Stroke

Drugs for Neonatal Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Hormone Antagonists Phase 3
8 Antineoplastic Agents, Hormonal Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Analgesics, Non-Narcotic Phase 3
11 Antirheumatic Agents Phase 3
12 Protective Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Prednisolone acetate Phase 3
15 Neuroprotective Agents Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
17 Antiemetics Phase 3
18 Methylprednisolone acetate Phase 3
19 Analgesics Phase 3
20 Antipyretics Phase 3
21 Hormones Phase 3
22 Peripheral Nervous System Agents Phase 3
23 Autonomic Agents Phase 3
24 Gastrointestinal Agents Phase 3
25 Anti-Inflammatory Agents Phase 3
26 Fibrinolytic Agents Phase 3
27 glucocorticoids Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
30 Hematinics Phase 2
31 Passionflower Phase 1, Phase 2
32
Phenobarbital Approved, Investigational Phase 1 50-06-6 4763
33
Bumetanide Approved Phase 1 28395-03-1 2471
34 diuretics Phase 1
35 Cytochrome P-450 CYP3A Inducers Phase 1
36 Excitatory Amino Acid Antagonists Phase 1
37 Neurotransmitter Agents Phase 1
38 GABA Agents Phase 1
39 Central Nervous System Depressants Phase 1
40 Anticonvulsants Phase 1
41 Sodium Potassium Chloride Symporter Inhibitors Phase 1
42 Excitatory Amino Acids Phase 1
43 GABA Modulators Phase 1
44 Hypnotics and Sedatives Phase 1
45 Natriuretic Agents Phase 1
46
Thrombin Approved, Investigational
47 Pharmaceutical Solutions

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
2 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
3 Paediatric Arteriopathy Steroid Aspirin Project Not yet recruiting NCT03249844 Phase 3 Methylprednisolone + prednisolone
4 Enhancing Motor Plasticity After Perinatal Stroke Using tDCS Completed NCT02170285 Phase 2
5 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
6 Perinatal Arterial Stroke Treated With Stromal Cells Intranasally Not yet recruiting NCT03356821 Phase 1, Phase 2
7 Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke Suspended NCT02460484 Phase 1, Phase 2
8 Transcranial Magnetic Stimulation in Children With Stroke Completed NCT01637129 Phase 1
9 Pilot Study of Bumetanide for Newborn Seizures Completed NCT00830531 Phase 1 Bumetanide;Normal Saline as Placebo
10 Umbilical Cord Blood in the Treatment of Stroke in Children. Withdrawn NCT01700166 Phase 1
11 Early Determinants of Multidimensional Outcome at School Age After Neonatal Arterial Ischemic Stroke Completed NCT02511249
12 Protein Supplementation in Infants With Brain Injury Completed NCT01936246 Not Applicable
13 Study of Abnormal Blood Clotting in Children With Stroke Completed NCT00001927
14 Perinatal Stroke: Understanding Brain Reorganization Recruiting NCT02743728 Not Applicable
15 Parent Therapist Partnership to Provide Early, Intensive Exercise in Perinatal Stroke Recruiting NCT03672864 Not Applicable
16 Early Intervention in Infants With Perinatal Stroke Recruiting NCT02720432 Not Applicable
17 FES in Young Children With Perinatal Stroke Recruiting NCT02975180 Not Applicable
18 Single-session tDCS in Cerebral Palsy Recruiting NCT03635775 Not Applicable
19 National Egyptian Network Pediatric Stroke and Hemiplegia Registry Recruiting NCT02129491
20 Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk Recruiting NCT03246243
21 Intensive Motor Training After Perinatal Stroke to Enhance Walking Active, not recruiting NCT01773369 Not Applicable

Search NIH Clinical Center for Neonatal Stroke

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem�, bone marrow-derived cells for ischemic and neonatal stroke
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285

Genetic Tests for Neonatal Stroke

Anatomical Context for Neonatal Stroke

MalaCards organs/tissues related to Neonatal Stroke:

41
Brain, Bone, Bone Marrow, Heart, Prostate, Thyroid, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Neonatal Stroke

Articles related to Neonatal Stroke:

(show top 50) (show all 126)
# Title Authors Year
1
Dose-Dependent Effect of Intravenous Administration of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Neonatal Stroke Mice. ( 29568282 )
2018
2
Manual dexterity, but not cerebral palsy, predicts cognitive functioning after neonatal stroke. ( 29624666 )
2018
3
Manual dexterity and cognitive outcome after neonatal stroke. ( 29671877 )
2018
4
Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke. ( 29852289 )
2018
5
Placental Pathology in Neonatal Stroke: A Retrospective Case-Control Study. ( 29397159 )
2018
6
Developmental conduction aphasia after neonatal stroke. ( 29572915 )
2018
7
Early intervention following neonatal stroke: closer towards targeted therapy. ( 30548862 )
2018
8
[Formula: see text]Attention and executive functioning profiles in children following perinatal arterial ischemic stroke. ( 27599397 )
2018
9
Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells. ( 28949952 )
2018
10
Neurodevelopment After Perinatal Arterial Ischemic Stroke. ( 30072575 )
2018
11
Long-term neurodevelopmental outcome after perinatal arterial ischemic stroke and periventricular venous infarction. ( 30249407 )
2018
12
Neonatal stroke and haematuria: Questions. ( 28717936 )
2017
13
Pathways for Neuroimaging of Neonatal Stroke. ( 28262550 )
2017
14
Neonatal stroke and haematuria: Answers. ( 28717939 )
2017
15
Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia. ( 29278365 )
2017
16
Role of seizure in neonatal stroke. ( 28562317 )
2017
17
Variability in Clinical Presentation of Neonatal Stroke: Report of Four Cases. ( 28194288 )
2017
18
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. ( 28518065 )
2017
19
Is there an excess of left-handedness after neonatal stroke? ( 28893386 )
2017
20
Clinical Predictors of Attention and Executive Functioning Outcomes in Children After Perinatal Arterial Ischemic Stroke. ( 28274640 )
2017
21
MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better. ( 28499876 )
2017
22
In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. ( 26782250 )
2016
23
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
24
Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. ( 27142685 )
2016
25
Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics? ( 27165960 )
2016
26
Evaluation of hypercoagulability state in perinatal arterial ischemic stroke with rotation thromboelastometry. ( 27514779 )
2016
27
Paradoxical centrally increased diffusivity in perinatal arterial ischemic stroke. ( 26238967 )
2016
28
Prediction of visual field defects in newborn infants with perinatal arterial ischemic stroke using early MRI and DTI-based tractography of the optic radiation. ( 26708504 )
2016
29
Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis. ( 27898024 )
2016
30
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency. ( 26250584 )
2015
31
Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. ( 25647744 )
2015
32
A Primer for Nurses on Perinatal/Neonatal Stroke. ( 26264800 )
2015
33
Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. ( 26223273 )
2015
34
Long term motor function after neonatal stroke: Lesion localization above all. ( 26512551 )
2015
35
Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke. ( 24444827 )
2014
36
Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. ( 24428836 )
2014
37
Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study. ( 24503061 )
2014
38
Are we considering neonatal stroke early enough in our differential diagnosis? ( 25468618 )
2014
39
Stem cells for neonatal stroke- the future is here. ( 25120432 )
2014
40
Barrier mechanisms in neonatal stroke. ( 25426016 )
2014
41
Association between hypoxia and perinatal arterial ischemic stroke: a meta-analysis. ( 24587227 )
2014
42
Mechanisms of perinatal arterial ischemic stroke. ( 24667913 )
2014
43
Diagnosis and acute management of perinatal arterial ischemic stroke. ( 25317375 )
2014
44
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. ( 23391775 )
2013
45
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. ( 22512322 )
2013
46
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. ( 23291519 )
2013
47
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. ( 23539530 )
2013
48
A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model. ( 23651512 )
2013
49
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. ( 23830950 )
2013
50
Quantification of white matter injury following neonatal stroke with serial DTI. ( 23478641 )
2013

Variations for Neonatal Stroke

Expression for Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for Neonatal Stroke

GO Terms for Neonatal Stroke

Biological processes related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood coagulation GO:0030195 8.62 PROC SERPINE1

Sources for Neonatal Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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