MCID: NNT003
MIFTS: 29

Neonatal Thyrotoxicosis

Categories: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

MalaCards integrated aliases for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12573
ICD9CM 36 775.3
NCIt 51 C114906
SNOMED-CT 69 13795004
ICD10 34 P72.1
UMLS 74 C0158983

Summaries for Neonatal Thyrotoxicosis

MalaCards based summary : Neonatal Thyrotoxicosis is related to graves disease 1 and thyroiditis. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Human Thyroid Stimulating Hormone (TSH) signaling pathway and Selenium Metabolism and Selenoproteins. Affiliated tissues include thyroid, pituitary and testes, and related phenotypes are cellular and growth/size/body region

Related Diseases for Neonatal Thyrotoxicosis

Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 31.0 TSHR TXNRD2
2 thyroiditis 29.6 TSHR TXNRD2
3 hypothyroidism 28.5 DIO3 LHX3 PAX8 PROP1 TSHR
4 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.1 LHX3 PROP1
5 septooptic dysplasia 10.1 LHX3 PROP1
6 combined pituitary hormone deficiency 10.0 LHX3 PROP1
7 pituitary hormone deficiency, combined, 2 10.0 LHX3 PROP1
8 borjeson-forssman-lehmann syndrome 10.0 LHX3 PROP1
9 pituitary gland disease 10.0 LHX3 PROP1
10 hyperthyroidism 10.0
11 hypopituitarism 10.0 LHX3 PROP1
12 athyreosis 9.9 PAX8 TSHR
13 pulmonary hypertension 9.9
14 graves' disease 9.9
15 hypothyroidism, congenital, nongoitrous, 2 9.9 PAX8 TSHR
16 multinodular goiter 9.9 PAX8 TSHR
17 follicular adenoma 9.9 PAX8 TSHR
18 papillary carcinoma 9.8 PAX8 TSHR
19 hashimoto thyroiditis 9.8
20 thyroid hormone resistance, generalized, autosomal dominant 9.8
21 chylothorax, congenital 9.8
22 congestive heart failure 9.8
23 craniosynostosis 9.8
24 bilirubin metabolic disorder 9.8
25 infertility 9.8
26 hypertensive encephalopathy 9.8
27 hypoglycemia 9.8
28 rere-related disorders 9.8
29 encephalopathy 9.8
30 differentiated thyroid carcinoma 9.7 PAX8 TSHR
31 congenital hypothyroidism 9.7 PAX8 TSHR
32 goiter 9.6 PAX8 TSHR TXNRD2
33 thyroid cancer, nonmedullary, 2 9.6 PAX8 TSHR
34 thyroid cancer 9.4 PAX8 TSHR TXNRD2
35 thyroid gland disease 9.3 DIO3 PAX8 TSHR TXNRD2

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to Neonatal Thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 DIO3 LHX3 PAX8 TSHR TXNRD2
2 growth/size/body region MP:0005378 9.77 DIO3 LHX3 PAX8 PROP1 TSHR
3 homeostasis/metabolism MP:0005376 9.73 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
4 mortality/aging MP:0010768 9.63 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
5 hearing/vestibular/ear MP:0005377 9.5 LHX3 PAX8 TSHR
6 nervous system MP:0003631 9.35 LHX3 PAX8 PROP1 TSHR TXNRD2
7 reproductive system MP:0005389 9.02 DIO3 LHX3 PAX8 PROP1 TSHR

Drugs & Therapeutics for Neonatal Thyrotoxicosis

Search Clinical Trials , NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

Anatomical Context for Neonatal Thyrotoxicosis

MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

42
Thyroid, Pituitary, Testes, Heart

Publications for Neonatal Thyrotoxicosis

Articles related to Neonatal Thyrotoxicosis:

(show top 50) (show all 60)
# Title Authors Year
1
Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease. ( 29736321 )
2018
2
Neonatal Thyrotoxicosis. ( 29406005 )
2018
3
Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review. ( 29325496 )
2018
4
Fetal/Neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto Thyroiditis. ( 27813690 )
2017
5
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. ( 25750228 )
2015
6
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. ( 25153577 )
2015
7
Images in clinical medicine. Neonatal thyrotoxicosis. ( 24670170 )
2014
8
Fetal and neonatal thyrotoxicosis. ( 24251220 )
2013
9
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. ( 22669869 )
2012
10
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. ( 18558604 )
2008
11
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. ( 15629961 )
2005
12
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. ( 14695499 )
2003
13
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. ( 12962270 )
2003
14
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. ( 12052596 )
2002
15
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). ( 12201835 )
2002
16
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. ( 10797041 )
2000
17
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. ( 10486076 )
1999
18
Congenital chylothorax in neonatal thyrotoxicosis. ( 10685206 )
1999
19
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. ( 2315685 )
1990
20
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. ( 2874029 )
1986
21
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. ( 3093659 )
1986
22
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. ( 2859196 )
1985
23
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. ( 6637335 )
1983
24
Hypertension in neonatal thyrotoxicosis. ( 7069539 )
1982
25
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. ( 7400892 )
1980
26
Neonatal thyrotoxicosis: a rare pediatric emergency. ( 6893645 )
1980
27
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. ( 6998280 )
1980
28
Complications of propranolol use in neonatal thyrotoxicosis. ( 7395835 )
1980
29
Oxygen consumption in the rat following neonatal thyrotoxicosis. ( 488304 )
1979
30
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. ( 581471 )
1978
31
Neonatal thyrotoxicosis following maternal hypothyroidism. ( 619059 )
1978
32
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. ( 650321 )
1978
33
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. ( 717342 )
1978
34
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. ( 576864 )
1977
35
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. ( 596245 )
1977
36
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. ( 830919 )
1977
37
Neonatal thyrotoxicosis. ( 899782 )
1977
38
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. ( 908154 )
1977
39
Neonatal thyrotoxicosis. ( 909013 )
1977
40
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. ( 946443 )
1976
41
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). ( 962368 )
1976
42
Attempted prevention of neonatal thyrotoxicosis. ( 990790 )
1976
43
Attempted prevention of neonatal thyrotoxicosis. ( 1000245 )
1976
44
Neonatal thyrotoxicosis. ( 1134079 )
1975
45
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. ( 1192685 )
1975
46
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. ( 4208653 )
1974
47
Neonatal thyrotoxicosis treated with propranolol. ( 4429365 )
1974
48
Propranolol in treatment of neonatal thyrotoxicosis. ( 4757519 )
1973
49
Neonatal thyrotoxicosis. ( 4800423 )
1973
50
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. ( 4677121 )
1972

Variations for Neonatal Thyrotoxicosis

Expression for Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for Neonatal Thyrotoxicosis

Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 PAX8 TSHR
2 10.29 DIO3 TXNRD2

GO Terms for Neonatal Thyrotoxicosis

Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PAX8 PROP1
2 animal organ morphogenesis GO:0009887 9.26 LHX3 PROP1
3 dorsal/ventral pattern formation GO:0009953 9.16 LHX3 PROP1
4 positive regulation of multicellular organism growth GO:0040018 8.96 DIO3 TSHR
5 thyroid-stimulating hormone signaling pathway GO:0038194 8.62 PAX8 TSHR

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 LHX3 PAX8 PROP1
2 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Neonatal Thyrotoxicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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