MCID: NNT003
MIFTS: 28

Neonatal Thyrotoxicosis

Categories: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

MalaCards integrated aliases for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12573
ICD10 33 P72.1
ICD9CM 35 775.3
NCIt 50 C114906
SNOMED-CT 68 13795004
UMLS 73 C0158983

Summaries for Neonatal Thyrotoxicosis

MalaCards based summary : Neonatal Thyrotoxicosis is related to thyroiditis and hypothyroidism. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Human Thyroid Stimulating Hormone (TSH) signaling pathway and Selenium Metabolism and Selenoproteins. Affiliated tissues include thyroid, heart and pituitary, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Neonatal Thyrotoxicosis

Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 thyroiditis 30.2 TSHR TXNRD2
2 hypothyroidism 27.1 DIO3 LHX3 PAX8 PROP1 TSHR
3 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.2 LHX3 PROP1
4 septooptic dysplasia 10.2 LHX3 PROP1
5 combined pituitary hormone deficiency 10.2 LHX3 PROP1
6 pituitary hormone deficiency, combined, 2 10.2 LHX3 PROP1
7 borjeson-forssman-lehmann syndrome 10.1 LHX3 PROP1
8 pituitary gland disease 10.1 LHX3 PROP1
9 graves disease 1 10.1 TSHR TXNRD2
10 hypopituitarism 10.0 LHX3 PROP1
11 neonatal hypothyroidism 9.9 PAX8 TSHR
12 athyreosis 9.9 PAX8 TSHR
13 hypothyroidism, congenital, nongoitrous, 2 9.9 PAX8 TSHR
14 hyperthyroidism 9.9
15 pulmonary hypertension 9.8
16 graves' disease 9.8
17 multinodular goiter 9.8 PAX8 TSHR
18 follicular adenoma 9.8 PAX8 TSHR
19 thyroid hormone resistance, generalized, autosomal dominant 9.6
20 chylothorax, congenital 9.6
21 congestive heart failure 9.6
22 craniosynostosis 9.6
23 infertility 9.6
24 placenta disease 9.6
25 hypertensive encephalopathy 9.6
26 hypoglycemia 9.6
27 encephalopathy 9.6
28 congenital hypothyroidism 9.6 PAX8 TSHR
29 papillary carcinoma 9.5 PAX8 TSHR
30 differentiated thyroid carcinoma 9.4 PAX8 TSHR
31 goiter 9.2 PAX8 TSHR TXNRD2
32 thyroid cancer, nonmedullary, 2 9.2 PAX8 TSHR
33 thyroid cancer 9.0 PAX8 TSHR TXNRD2
34 thyroid gland disease 8.6 DIO3 PAX8 TSHR TXNRD2

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to Neonatal Thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
2 mortality/aging MP:0010768 9.43 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
3 reproductive system MP:0005389 9.02 DIO3 LHX3 PAX8 PROP1 TSHR

Drugs & Therapeutics for Neonatal Thyrotoxicosis

Search Clinical Trials , NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

Anatomical Context for Neonatal Thyrotoxicosis

MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

41
Thyroid, Heart, Pituitary, Testes

Publications for Neonatal Thyrotoxicosis

Articles related to Neonatal Thyrotoxicosis:

(show top 50) (show all 60)
# Title Authors Year
1
Neonatal Thyrotoxicosis. ( 29406005 )
2018
2
Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease. ( 29736321 )
2018
3
Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review. ( 29325496 )
2018
4
Fetal/neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto's Thyroiditis. ( 27813690 )
2016
5
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. ( 25750228 )
2015
6
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. ( 25153577 )
2014
7
Images in clinical medicine. Neonatal thyrotoxicosis. ( 24670170 )
2014
8
Fetal and neonatal thyrotoxicosis. ( 24251220 )
2013
9
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. ( 22669869 )
2012
10
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. ( 18558604 )
2008
11
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. ( 15629961 )
2005
12
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. ( 12962270 )
2003
13
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. ( 14695499 )
2003
14
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. ( 12052596 )
2002
15
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). ( 12201835 )
2002
16
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. ( 10797041 )
2000
17
Congenital chylothorax in neonatal thyrotoxicosis. ( 10685206 )
1999
18
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. ( 10486076 )
1999
19
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. ( 2315685 )
1990
20
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. ( 2874029 )
1986
21
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. ( 3093659 )
1986
22
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. ( 2859196 )
1985
23
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. ( 6637335 )
1983
24
Hypertension in neonatal thyrotoxicosis. ( 7069539 )
1982
25
Neonatal thyrotoxicosis: a rare pediatric emergency. ( 6893645 )
1980
26
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. ( 6998280 )
1980
27
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. ( 7400892 )
1980
28
Complications of propranolol use in neonatal thyrotoxicosis. ( 7395835 )
1980
29
Oxygen consumption in the rat following neonatal thyrotoxicosis. ( 488304 )
1979
30
Neonatal thyrotoxicosis following maternal hypothyroidism. ( 619059 )
1978
31
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. ( 650321 )
1978
32
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. ( 581471 )
1978
33
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. ( 717342 )
1978
34
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. ( 596245 )
1977
35
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. ( 908154 )
1977
36
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. ( 576864 )
1977
37
Neonatal thyrotoxicosis. ( 909013 )
1977
38
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. ( 830919 )
1977
39
Neonatal thyrotoxicosis. ( 899782 )
1977
40
Attempted prevention of neonatal thyrotoxicosis. ( 990790 )
1976
41
Attempted prevention of neonatal thyrotoxicosis. ( 1000245 )
1976
42
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). ( 962368 )
1976
43
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. ( 946443 )
1976
44
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. ( 1192685 )
1975
45
Neonatal thyrotoxicosis. ( 1134079 )
1975
46
Neonatal thyrotoxicosis treated with propranolol. ( 4429365 )
1974
47
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. ( 4208653 )
1974
48
Propranolol in treatment of neonatal thyrotoxicosis. ( 4757519 )
1973
49
Neonatal thyrotoxicosis. ( 4800423 )
1973
50
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. ( 4677121 )
1972

Variations for Neonatal Thyrotoxicosis

Expression for Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for Neonatal Thyrotoxicosis

Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 PAX8 TSHR
2 10.29 DIO3 TXNRD2

GO Terms for Neonatal Thyrotoxicosis

Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.43 LHX3 PAX8 PROP1
2 central nervous system development GO:0007417 9.37 PAX8 PROP1
3 animal organ morphogenesis GO:0009887 9.32 LHX3 PROP1
4 dorsal/ventral pattern formation GO:0009953 9.16 LHX3 PROP1
5 positive regulation of multicellular organism growth GO:0040018 8.96 DIO3 TSHR
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.62 PAX8 TSHR

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Neonatal Thyrotoxicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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