MCID: NNT003
MIFTS: 27

Neonatal Thyrotoxicosis

Categories: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

MalaCards integrated aliases for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 12 54 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12573
ICD9CM 34 775.3
NCIt 50 C114906
SNOMED-CT 67 13795004
ICD10 32 P72.1
UMLS 70 C0158983

Summaries for Neonatal Thyrotoxicosis

MalaCards based summary : Neonatal Thyrotoxicosis is related to graves disease 1 and hyperthyroidism. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Angiopoietin Like Protein 8 Regulatory Pathway and Thyroid hormone signaling pathway. Affiliated tissues include thyroid, pituitary and heart, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Neonatal Thyrotoxicosis

Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 30.6 TSHR SLC16A2 DIO3 DIO2
2 hyperthyroidism 30.2 TSHR SLC16A2
3 thyroid hormone resistance, generalized, autosomal dominant 29.2 TSHR THRA SLC16A2
4 hypothyroidism 28.6 TSHR THRA PROP1 LHX3 DIO3 DIO2
5 congenital hypothyroidism 27.9 TSHR THRA SLC16A2 PROP1 LHX3 DIO2
6 graves' disease 10.4
7 goiter 10.1
8 diabetes mellitus, neonatal, with congenital hypothyroidism 10.1 TSHR SLC16A2
9 toxic diffuse goiter 10.1 TSHR DIO2
10 pulmonary hypertension 10.0
11 bilirubin metabolic disorder 10.0
12 congestive heart failure 10.0
13 euthyroid sick syndrome 10.0 SLC16A2 DIO2
14 familial partial lipodystrophy 9.9 SLC16A2 DIO2
15 hypothyroidism due to deficient transcription factors involved in pituitary development or function 9.9 PROP1 LHX3
16 empty sella syndrome 9.9 PROP1 LHX3
17 follicular adenoma 9.9 TSHR DIO2
18 acth deficiency, isolated 9.9 PROP1 LHX3
19 borjeson-forssman-lehmann syndrome 9.9 PROP1 LHX3
20 hyperthyroxinemia 9.9 TSHR THRA
21 pituitary hormone deficiency, combined, 2 9.8 PROP1 LHX3
22 hashimoto thyroiditis 9.8
23 chylothorax, congenital 9.8
24 respiratory failure 9.8
25 heart disease 9.8
26 neutropenia 9.8
27 pneumothorax 9.8
28 craniosynostosis 9.8
29 tricuspid valve insufficiency 9.8
30 infertility 9.8
31 thyroiditis 9.8
32 hypertensive encephalopathy 9.8
33 hypoglycemia 9.8
34 encephalopathy 9.8
35 pituitary gland disease 9.8 PROP1 LHX3
36 septooptic dysplasia 9.8 PROP1 LHX3
37 hypopituitarism 9.7 PROP1 LHX3
38 thyroid gland disease 9.4 TSHR THRA SLC16A2 DIO2
39 allan-herndon-dudley syndrome 9.4 THRA SLC16A2 DIO3 DIO2

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to Neonatal Thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.35 DIO2 LHX3 PROP1 THRA TSHR
2 homeostasis/metabolism MP:0005376 9.17 DIO2 DIO3 LHX3 PROP1 SLC16A2 THRA

Drugs & Therapeutics for Neonatal Thyrotoxicosis

Search Clinical Trials , NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

Anatomical Context for Neonatal Thyrotoxicosis

MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

40
Thyroid, Pituitary, Heart, Fetal Thyroid, Breast

Publications for Neonatal Thyrotoxicosis

Articles related to Neonatal Thyrotoxicosis:

(show top 50) (show all 138)
# Title Authors PMID Year
1
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. 54 61
18558604 2008
2
[Neonatal hyperthyroidism in a premature infant born to a mother with Grave's disease]. 61 54
10855389 2000
3
[Treatment of Basedow-Graves disease in pregnancy]. 54 61
8532325 1995
4
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. 61 54
2315685 1990
5
50 Years Ago in TheJournalofPediatrics: Advances in Neonatal Thyrotoxicosis. 61
33766296 2021
6
Neonatal Thyrotoxicosis Co-existing With Early Onset Sepsis. 61
33452787 2021
7
Role of Maternal Thyroid-Stimulating Immunoglobulin in Graves' Disease for Predicting Perinatal Thyroid Dysfunction. 61
31723454 2019
8
[Newborn of mothers with Graves' disease]. 61
30725065 2018
9
Thyrotropin Receptor Antibodies-An Overview. 61
29771756 2018
10
Neonatal Thyrotoxicosis with Tricuspid Valve Regurgitation and Hydrops in a Preterm Infant Born to a Mother with Graves' Disease. 61
29736321 2018
11
Neonatal Thyrotoxicosis. 61
29406005 2018
12
Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review. 61
29325496 2018
13
Measuring TSH receptor antibody to influence treatment choices in Graves' disease. 61
28295509 2017
14
Fetal/Neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto Thyroiditis. 61
27813690 2017
15
Biochemical Hyperthyroidism in a Newborn Baby Caused by Assay Interaction from Biotin Intake. 61
27843813 2016
16
Topical Iodine-Induced Thyrotoxicosis in a Newborn with a Giant Omphalocele. 61
27551578 2016
17
Fetal Hyperthyroidism: Intrauterine Treatment with Carbimazole in Two Siblings. 61
25952662 2015
18
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. 61
25153577 2015
19
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. 61
25750228 2015
20
Neonatal Graves' disease with unusual metabolic association from presentation to resolution. 61
25422339 2014
21
Pregnancy after definitive treatment for Graves' disease--does treatment choice influence outcome? 61
24576228 2014
22
Follow-up of newborns of mothers with Graves' disease. 61
24472020 2014
23
Images in clinical medicine. Neonatal thyrotoxicosis. 61
24670170 2014
24
Hyperthyroidism in pregnancy. 61
24622372 2013
25
[Neonatal hyperthyroidism: a case report and literature review]. 61
24144770 2013
26
Fetal and neonatal thyrotoxicosis. 61
24251220 2013
27
Clinical review: Clinical utility of TSH receptor antibodies. 61
23539719 2013
28
Residual thyroid tissue after thyroidectomy in a patient with TSH receptor-activating mutation presenting as a neck mass. 61
23271753 2013
29
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. 61
22669869 2012
30
Complete hydatidiform mole coexisting with a live fetus. 61
22905482 2012
31
Fetal and neonatal Graves disease: a case report and review of the literature. 61
18622337 2008
32
[Graves disease in pregnancy a risk for the child. Maternal TSH receptor antibodies can cause fetal and neonatal thyrotoxicosis]. 61
18290505 2008
33
Fetal therapy in fetal thyrotoxicosis: a case report. 61
18033967 2008
34
[Transient neonatal thyrotoxicosis: clinical presentation and treatment in 7 cases]. 61
17651947 2007
35
Therapy insight: management of Graves' disease during pregnancy. 61
17515891 2007
36
[Development of neonatal Graves' disease--prediction, prevention and treatment]. 61
17154096 2006
37
Acquired neonatal thyroid disease due to TSH receptor antibodies in breast milk. 61
16886586 2006
38
Type 3 deiodinase is critical for the maturation and function of the thyroid axis. 61
16410833 2006
39
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. 61
15629961 2005
40
[Severe neonatal hyperthyroidism which reveals a maternal Graves' disease]. 61
15247872 2004
41
Iopanoic acid in the management of neonatal Graves' disease. 61
14762455 2004
42
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. 61
14695499 2003
43
Serial in utero ultrasonographic measurements of the fetal thyroid: a new complementary tool in the management of maternal hyperthyroidism in pregnancy. 61
12975785 2003
44
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. 61
12962270 2003
45
Foetal and neonatal thyroid disorders. 61
12244277 2002
46
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). 61
12201835 2002
47
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. 61
12052596 2002
48
[Timely recognition and treatment of hypothyroidism in pregnant women: benefit for the child]. 61
11332250 2001
49
Congenital thyrotoxicosis in premature infants. 61
11298090 2001
50
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. 61
10797041 2000

Variations for Neonatal Thyrotoxicosis

Expression for Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for Neonatal Thyrotoxicosis

GO Terms for Neonatal Thyrotoxicosis

Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.5 TSHR THRA DIO2
2 positive regulation of multicellular organism growth GO:0040018 9.46 TSHR DIO3
3 pituitary gland development GO:0021983 9.43 PROP1 LHX3
4 thyroid hormone generation GO:0006590 9.4 DIO3 DIO2
5 hormone biosynthetic process GO:0042446 9.37 DIO3 DIO2
6 hormone-mediated signaling pathway GO:0009755 9.33 TSHR THRA GPHB5
7 regulation of thyroid hormone mediated signaling pathway GO:0002155 9.26 THRA GPHB5
8 thyroid hormone catabolic process GO:0042404 8.96 DIO3 DIO2
9 thyroid hormone metabolic process GO:0042403 8.8 SLC16A2 DIO3 DIO2

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroxine 5'-deiodinase activity GO:0004800 8.96 DIO3 DIO2
2 thyroxine 5-deiodinase activity GO:0033798 8.62 DIO3 DIO2

Sources for Neonatal Thyrotoxicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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