MCID: NPH006
MIFTS: 34

Nephrogenic Adenofibroma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 12 15 73
Metanephric Adenofibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2698
NCIt 50 C39812
UMLS 73 C1266141

Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to renal cell carcinoma, nonpapillary and wilms tumor 6. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include kidney, lung and skin, and related phenotypes are Decreased sensitivity to paclitaxel and embryo

Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 29.9 CA9 KRT7 KRT8 MME PAX2 PAX8
2 wilms tumor 6 10.5
3 adenofibroma 10.3
4 fallopian tube carcinosarcoma 10.3 NCAM1 WT1
5 balloon cell malignant melanoma 10.3 KRT7 MME
6 childhood endodermal sinus tumor 10.3 PAX2 PAX8
7 cervix endometriosis 10.3 MME PAX2
8 plasma cell leukemia 10.3 MAF NCAM1
9 endolymphatic sac tumor 10.3 KRT7 KRT8
10 renal pelvis adenocarcinoma 10.3 KRT7 PAX8
11 extrahepatic bile duct adenocarcinoma 10.2 MME NCAM1
12 sensory organ benign neoplasm 10.2 KRT7 PAX8
13 clear cell hidradenoma 10.2 MME PAX8
14 nephrogenic adenoma of urinary bladder 10.2 KRT7 PAX2 PAX8
15 nephrogenic adenoma 10.2 KRT7 PAX2 PAX8
16 endosalpingiosis 10.2 KRT7 PAX8 WT1
17 bladder benign neoplasm 10.2 KRT7 PAX2 PAX8
18 peritoneum cancer 10.2 KRT7 PAX8 WT1
19 urethral diverticulum 10.2 KRT7 PAX8 WT1
20 clear cell adenocarcinoma 10.2 KRT7 PAX2 PAX8
21 angiokeratoma of fordyce 10.2 HBA1 WT1
22 hidrocystoma 10.2 KRT7 KRT8
23 endocervical adenocarcinoma 10.2 KRT7 PAX2 PAX8
24 adenocarcinoma in situ 10.2 KRT7 PAX2 PAX8
25 ovarian cancer 1 10.2 KRT7 PAX8 WT1
26 cystadenofibroma 10.2 KRT7 MME NCAM1
27 neurenteric cyst 10.2 KRT18 KRT8
28 scleral staphyloma 10.2 NF1 PAX2
29 malignant ovarian surface epithelial-stromal neoplasm 10.2 KRT7 PAX8 WT1
30 ovary epithelial cancer 10.2 KRT7 PAX8 WT1
31 malignant triton tumor 10.2 MYOD1 NF1
32 rete testis adenoma 10.2 NCAM1 PAX2 PAX8
33 spermatocele 10.2 MME NCAM1 PAX2
34 mixed endometrial stromal and smooth muscle tumor 10.2 CALD1 MME
35 collecting duct carcinoma 10.2 KRT7 MME PAX8
36 metanephric adenoma 10.2 KRT18 KRT7 WT1
37 epithelioid trophoblastic tumor 10.2 KRT18 KRT7
38 apocrine sweat gland neoplasm 10.2 KRT7 KRT8
39 malignant glandular tumor of peripheral nerve sheath 10.2 B3GAT1 NF1
40 kidney rhabdoid cancer 10.2 B3GAT1 WT1
41 endocervical carcinoma 10.2 KRT7 PAX8
42 benign mesothelioma 10.2 HBA1 KRT7 WT1
43 merkel cell carcinoma 10.2 KRT7 KRT8 NCAM1
44 gastric tubular adenocarcinoma 10.2 CHL1 KRT7 KRT8
45 gastric small cell carcinoma 10.2 B3GAT1 CHL1 NCAM1
46 malignant leydig cell tumor 10.2 KRT7 MME
47 proliferating trichilemmal cyst 10.2 KRT18 KRT7 KRT8
48 cutaneous adenocystic carcinoma 10.2 KRT18 KRT7 KRT8
49 prostatic acinar adenocarcinoma 10.2 KRT7 PAX2 PAX8 WT1
50 lymphoepithelioma-like carcinoma 10.2 KRT18 KRT7 KRT8

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to Nephrogenic Adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 WT1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 KRT18 KRT8 MYOG NF1 PAX2 PAX8
2 mortality/aging MP:0010768 9.47 B3GAT1 CA9 KRT18 KRT8 MAF MYOD1

Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

41
Kidney, Lung, Skin, Liver, Bone, Spleen, Thyroid

Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

# Title Authors Year
1
An "accidental" discovery: Incidentally found metanephric adenofibroma in a 5-year-old male trauma patient. ( 30026886 )
2018
2
Metanephric Adenofibroma Masquerading as Wilms' Tumor. ( 27900278 )
2016
3
Nephrogenic adenofibroma in a young child. ( 11156329 )
2000
4
Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )
1997
5
Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )
1992

Variations for Nephrogenic Adenofibroma

Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for Nephrogenic Adenofibroma

GO Terms for Nephrogenic Adenofibroma

Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
2 cell periphery GO:0071944 8.8 CD34 KRT18 KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 MYOD1 MYOG PAX2 PAX8 SS18 WT1
2 kidney development GO:0001822 9.83 MME PAX8 WT1
3 cornification GO:0070268 9.81 KRT18 KRT7 KRT8
4 skeletal muscle tissue development GO:0007519 9.71 MYOD1 MYOG NF1
5 branching involved in ureteric bud morphogenesis GO:0001658 9.67 PAX2 PAX8 WT1
6 positive regulation of myoblast fusion GO:1901741 9.64 MYOD1 MYOG
7 urogenital system development GO:0001655 9.63 PAX2 PAX8
8 mesonephros development GO:0001823 9.63 PAX2 PAX8
9 myotube differentiation GO:0014902 9.62 MYOD1 MYOG
10 hepatocyte apoptotic process GO:0097284 9.62 KRT18 KRT8
11 mesenchymal to epithelial transition GO:0060231 9.61 PAX2 WT1
12 positive regulation of skeletal muscle fiber development GO:0048743 9.61 MYOD1 MYOG
13 cellular response to gonadotropin stimulus GO:0071371 9.6 PAX8 WT1
14 metanephric mesenchyme development GO:0072075 9.59 PAX2 WT1
15 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.58 PAX2 PAX8
16 muscle cell fate commitment GO:0042693 9.57 MYOD1 MYOG
17 pronephros development GO:0048793 9.56 PAX2 PAX8
18 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX2 PAX8
19 metanephric S-shaped body morphogenesis GO:0072284 9.52 PAX8 WT1
20 metanephric distal convoluted tubule development GO:0072221 9.48 PAX2 PAX8
21 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
22 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.43 PAX2 PAX8
23 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
24 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.37 PAX2 PAX8
25 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX2 PAX8
26 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX2 PAX8
27 positive regulation of metanephric DCT cell differentiation GO:2000594 9.16 PAX2 PAX8
28 pronephric field specification GO:0039003 8.96 PAX2 PAX8
29 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 MAF MYOD1 MYOG PAX2 PAX8 SS18
31 transcription by RNA polymerase II GO:0006366 10.04 MAF MYOD1 PAX2 PAX8 WT1

Molecular functions related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.26 MAF MYOG PAX8 WT1
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 MAF MYOD1 MYOG WT1

Sources for Nephrogenic Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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