Nephrogenic Adenofibroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma ¹² ¹⁵ ⁷³

Metanephric Adenofibroma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Nephrological diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2698

NCIt ⁵⁰ C39812

SNOMED-CT ⁶⁸ 128760004

UMLS ⁷³ C1266141

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Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to fallopian tube carcinosarcoma and childhood endodermal sinus tumor. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include kidney, and related phenotypes are Decreased sensitivity to paclitaxel and embryo

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Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)

#	Related Disease	Score	Top Affiliating Genes
1	fallopian tube carcinosarcoma	10.9	NCAM1 WT1
2	childhood endodermal sinus tumor	10.9	PAX2 PAX8
3	balloon cell malignant melanoma	10.9	KRT7 MME
4	endolymphatic sac tumor	10.9	KRT7 KRT8
5	ovarian large-cell neuroendocrine carcinoma	10.9	KRT7 NCAM1
6	cervix endometriosis	10.9	MME PAX2
7	plasma cell leukemia	10.9	MAF NCAM1
8	female reproductive endometrioid cancer	10.9	KRT7 WT1
9	sensory organ benign neoplasm	10.9	KRT7 NCAM1
10	renal pelvis adenocarcinoma	10.9	KRT7 PAX8
11	nephrogenic adenoma of urinary bladder	10.8	KRT7 PAX2 PAX8
12	endosalpingiosis	10.8	KRT7 PAX8 WT1
13	clear cell hidradenoma	10.8	MME PAX8
14	angioimmunoblastic t-cell lymphoma	10.8	MAF MME
15	bladder benign neoplasm	10.8	KRT7 PAX2 PAX8
16	nephrogenic adenoma	10.8	KRT7 PAX2 PAX8
17	extrahepatic bile duct adenocarcinoma	10.8	MME NCAM1
18	urethral diverticulum	10.8	KRT7 PAX8 WT1
19	hidrocystoma	10.8	KRT7 KRT8
20	endocervical adenocarcinoma	10.8	KRT7 PAX2 PAX8
21	neurenteric cyst	10.7	KRT18 KRT8
22	adenocarcinoma in situ	10.7	KRT7 PAX2 PAX8
23	ovarian cancer 1	10.7	KRT7 PAX8 WT1
24	angiokeratoma of fordyce	10.7	HBA1 WT1
25	malignant ovarian surface epithelial-stromal neoplasm	10.7	KRT7 PAX8 WT1
26	ovary epithelial cancer	10.7	KRT7 PAX8 WT1
27	wilms tumor 5	10.7	PAX2 PAX8 WT1
28	collecting duct carcinoma	10.7	KRT7 MME PAX8
29	rete testis adenoma	10.7	NCAM1 PAX2 PAX8
30	endocervical carcinoma	10.7	KRT7 PAX8
31	cystadenofibroma	10.7	KRT7 MME NCAM1
32	mixed endometrial stromal and smooth muscle tumor	10.7	CALD1 MME
33	apocrine sweat gland neoplasm	10.7	KRT7 KRT8
34	spermatocele	10.7	MME NCAM1 PAX2
35	metanephric adenoma	10.7	KRT18 KRT7 WT1
36	scleral staphyloma	10.6	NF1 PAX2
37	epithelioid trophoblastic tumor	10.6	KRT18 KRT7
38	malignant glandular tumor of peripheral nerve sheath	10.6	B3GAT1 NF1
39	gastric tubular adenocarcinoma	10.6	CHL1 KRT7 KRT8
40	adenoid squamous cell carcinoma	10.6	HBA1 KRT7
41	merkel cell carcinoma	10.6	KRT7 KRT8 NCAM1
42	proliferating trichilemmal cyst	10.6	KRT18 KRT7 KRT8
43	cutaneous adenocystic carcinoma	10.6	KRT18 KRT7 KRT8
44	pleomorphic carcinoma	10.6	KRT18 KRT7 KRT8
45	lymphoepithelioma-like carcinoma	10.6	KRT18 KRT7 KRT8
46	mammary paget's disease	10.5	KRT18 KRT7 KRT8
47	kidney rhabdoid cancer	10.5	B3GAT1 WT1
48	malignant leydig cell tumor	10.5	KRT7 MME
49	primary cutaneous amyloidosis	10.5	KRT18 KRT7 KRT8
50	adenosquamous carcinoma	10.5	KRT18 KRT7 KRT8

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:

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Symptoms & Phenotypes for Nephrogenic Adenofibroma

GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased sensitivity to paclitaxel	GR00112-A-0	8.62	NF1 WT1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	embryo	MP:0005380	9.56	KRT18 KRT8 MYOG NF1 PAX2 PAX8
2	mortality/aging	MP:0010768	9.47	B3GAT1 CA9 KRT18 KRT8 MAF MYOD1

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Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

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Genetic Tests for Nephrogenic Adenofibroma

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Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

⁴¹

Kidney

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Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

#	Title	Authors	Year
1	Nephrogenic adenofibroma in a young child. ( 11156329 )	Guzman E....Michiels J.F.	2000
2	Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )	Bigg S.W....Bari W.A.	1997
3	Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )	Hennigar R.A....Beckwith J.B.	1992

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Genes for Nephrogenic Adenofibroma

Genes related to Nephrogenic Adenofibroma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MAF	MAF BZIP Transcription Factor	Protein Coding	16.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PDLIM5	PDZ And LIM Domain 5	Protein Coding	15.11	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	KRT7	Keratin 7	Protein Coding	14.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	WT1	Wilms Tumor 1	Protein Coding	14.77	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PAX2	Paired Box 2	Protein Coding	14.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MYOD1	Myogenic Differentiation 1	Protein Coding	14.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	PAX8	Paired Box 8	Protein Coding	14.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	MME	Membrane Metalloendopeptidase	Protein Coding	14.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	14.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	KRT8	Keratin 8	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	CHL1	Cell Adhesion Molecule L1 Like	Protein Coding	14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	B3GAT1	Beta-1,3-Glucuronyltransferase 1	Protein Coding	13.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	KRT18	Keratin 18	Protein Coding	13.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	NF1	Neurofibromin 1	Protein Coding	13.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	13.07	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	CALD1	Caldesmon 1	Protein Coding	5.35	DISEASES inferred ¹⁵
17	SS18	SS18, NBAF Chromatin Remodeling Complex Subunit	Protein Coding	5.09	DISEASES inferred ¹⁵
18	MYOG	Myogenin	Protein Coding	4.27	DISEASES inferred ¹⁵
19	CD34	CD34 Molecule	Protein Coding	4.04	DISEASES inferred ¹⁵
20	CA9	Carbonic Anhydrase 9	Protein Coding	3.89	DISEASES inferred ¹⁵

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Variations for Nephrogenic Adenofibroma

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Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

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Pathways for Nephrogenic Adenofibroma

Pathways related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.07	CHL1 KRT18 KRT7 KRT8 MYOD1 MYOG
2	Cytoskeletal Signaling ⁴	12.22	CALD1 KRT18 KRT7 KRT8
3	Transcriptional misregulation in cancer ³⁷	11.73	MAF PAX8 SS18 WT1
4	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.61	KRT18 KRT7 KRT8
5	C-MYB transcription factor network ¹	11.44	CD34 MAF MYOD1
6	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	CD34 MME NCAM1
7	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.13	KRT8 MME PAX2 WT1
8	ID signaling pathway ¹	10	MYOD1 PAX2 PAX8

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GO Terms for Nephrogenic Adenofibroma

Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratin filament	GO:0045095	9.13	KRT18 KRT7 KRT8
2	cell periphery	GO:0071944	8.8	CD34 KRT18 KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.99	MYOD1 MYOG PAX2 PAX8 SS18 WT1
2	cornification	GO:0070268	9.82	KRT18 KRT7 KRT8
3	kidney development	GO:0001822	9.81	MME PAX8 WT1
4	skeletal muscle tissue development	GO:0007519	9.71	MYOD1 MYOG NF1
5	branching involved in ureteric bud morphogenesis	GO:0001658	9.67	PAX2 PAX8 WT1
6	positive regulation of myoblast fusion	GO:1901741	9.64	MYOD1 MYOG
7	urogenital system development	GO:0001655	9.63	PAX2 PAX8
8	mesonephros development	GO:0001823	9.63	PAX2 PAX8
9	myotube differentiation	GO:0014902	9.62	MYOD1 MYOG
10	hepatocyte apoptotic process	GO:0097284	9.62	KRT18 KRT8
11	mesenchymal to epithelial transition	GO:0060231	9.61	PAX2 WT1
12	positive regulation of skeletal muscle fiber development	GO:0048743	9.61	MYOD1 MYOG
13	cellular response to gonadotropin stimulus	GO:0071371	9.6	PAX8 WT1
14	metanephric mesenchyme development	GO:0072075	9.59	PAX2 WT1
15	mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0003337	9.58	PAX2 PAX8
16	pronephros development	GO:0048793	9.57	PAX2 PAX8
17	regulation of metanephric nephron tubule epithelial cell differentiation	GO:0072307	9.56	PAX2 PAX8
18	muscle cell fate commitment	GO:0042693	9.55	MYOD1 MYOG
19	metanephric S-shaped body morphogenesis	GO:0072284	9.52	PAX8 WT1
20	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:0072108	9.48	PAX2 PAX8
21	metanephric nephron tubule formation	GO:0072289	9.46	PAX2 PAX8
22	metanephric distal convoluted tubule development	GO:0072221	9.43	PAX2 PAX8
23	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	GO:1900212	9.4	PAX2 PAX8
24	pronephric field specification	GO:0039003	9.37	PAX2 PAX8
25	positive regulation of metanephric DCT cell differentiation	GO:2000594	9.32	PAX2 PAX8
26	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	GO:0072305	9.26	PAX2 PAX8
27	negative regulation of apoptotic process involved in metanephric collecting duct development	GO:1900215	9.16	PAX2 PAX8
28	negative regulation of apoptotic process involved in metanephric nephron tubule development	GO:1900218	8.96	PAX2 PAX8
29	metanephric epithelium development	GO:0072207	8.8	PAX2 PAX8 WT1
30	positive regulation of transcription by RNA polymerase II	GO:0045944	10.12	MAF MYOD1 MYOG PAX2 PAX8 SS18

Molecular functions related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.58	CA9 CALD1 CHL1 HBA1 KRT18 KRT7

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