MCID: NPH006
MIFTS: 26

Nephrogenic Adenofibroma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 12 15 74
Metanephric Adenofibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2698
NCIt 51 C39812
UMLS 74 C1266141

Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to renal cell carcinoma, nonpapillary and wilms tumor 5. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include kidney, ovary and prostate, and related phenotype is renal/urinary system.

Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 29.6 KRT7 PAX2 WT1
2 wilms tumor 5 10.5
3 wilms tumor 6 10.5
4 adenofibroma 10.4
5 nephrogenic adenoma of urinary bladder 10.0 KRT7 PAX2
6 nephrogenic adenoma 10.0 KRT7 PAX2
7 bladder benign neoplasm 10.0 KRT7 PAX2
8 nail-patella syndrome 10.0 PAX2 PDLIM5
9 endocervical adenocarcinoma 10.0 KRT7 PAX2
10 adenocarcinoma in situ 10.0 KRT7 PAX2
11 clear cell adenocarcinoma 9.9 KRT7 PAX2
12 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 9.9 PAX2 WT1
13 mayer-rokitansky-kuster-hauser syndrome 9.9 PAX2 WT1
14 denys-drash syndrome 9.8 PAX2 WT1
15 benign mesothelioma 9.8 KRT7 WT1
16 endosalpingiosis 9.8 KRT7 WT1
17 renal adenoma 9.8 KRT7 WT1
18 female reproductive endometrioid cancer 9.8 KRT7 WT1
19 diffuse mesangial sclerosis 9.8 PAX2 WT1
20 malignant biphasic mesothelioma 9.8 KRT7 WT1
21 metanephric adenoma 9.8 KRT7 WT1
22 adenomatoid tumor 9.8 KRT7 WT1
23 peritoneum cancer 9.8 KRT7 WT1
24 urethral diverticulum 9.8 KRT7 WT1
25 sertoli-leydig cell tumor 9.8 KRT7 WT1
26 ovarian mucinous neoplasm 9.8 KRT7 WT1
27 sex cord-gonadal stromal tumor 9.8 KRT7 WT1
28 dysgerminoma 9.8 KRT7 WT1
29 ovarian cancer 1 9.7 KRT7 WT1
30 clear cell renal cell carcinoma 9.7 KRT7 PAX2
31 malignant ovarian surface epithelial-stromal neoplasm 9.7 KRT7 WT1
32 ovary epithelial cancer 9.7 KRT7 WT1
33 renal cell carcinoma, papillary, 1 9.7 KRT7 WT1
34 chronic kidney failure 9.7 PAX2 WT1
35 mesothelioma, malignant 9.7 KRT7 WT1
36 epithelial predominant wilms' tumor 9.6 KRT7 MAF WT1
37 kidney benign neoplasm 9.6 KRT7 PAX2 WT1
38 prostatic acinar adenocarcinoma 9.6 KRT7 PAX2 WT1
39 ovarian brenner tumor 9.6 KRT7 PAX2 WT1
40 wilms tumor 1 9.5 KRT7 PAX2 WT1
41 focal segmental glomerulosclerosis 9.5 PAX2 WT1

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to Nephrogenic Adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 KRT7 MAF PAX2 WT1

Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

42
Kidney, Ovary, Prostate

Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

(show all 13)
# Title Authors Year
1
An "accidental" discovery: Incidentally found metanephric adenofibroma in a 5-year-old male trauma patient. ( 30026886 )
2018
2
Metanephric Adenofibroma In A Young Adult. ( 27802007 )
2017
3
Metanephric Adenofibroma Masquerading as Wilms' Tumor. ( 27900278 )
2016
4
Metanephric adenofibroma in a 10-year-old boy: report of a case and review of the literature. ( 26045848 )
2015
5
Application of BRAF V600E mutation analysis for the diagnosis of metanephric adenofibroma. ( 26274032 )
2015
6
Metanephric adenofibroma. ( 23587517 )
2013
7
A composite renal tumor: metanephric adenofibroma, Wilms tumor, and renal cell carcinoma: a missing link? ( 21711207 )
2012
8
Metanephric adenofibroma: robotic partial nephrectomy of a large Wilms' tumor variant. ( 20735912 )
2010
9
The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. ( 11257617 )
2001
10
Nephrogenic adenofibroma in a young child. ( 11156329 )
2000
11
Metanephric adenofibroma: report of a case and review of the literature. ( 10366157 )
1999
12
Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )
1997
13
Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )
1992

Variations for Nephrogenic Adenofibroma

Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for Nephrogenic Adenofibroma

Pathways related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.43 MAF WT1
2 11.08 PAX2 WT1
3 10.49 PAX2 WT1

GO Terms for Nephrogenic Adenofibroma

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.37 MAF PAX2
2 camera-type eye development GO:0043010 9.32 PAX2 WT1
3 branching involved in ureteric bud morphogenesis GO:0001658 9.26 PAX2 WT1
4 mesenchymal to epithelial transition GO:0060231 9.16 PAX2 WT1
5 metanephric mesenchyme development GO:0072075 8.96 PAX2 WT1
6 metanephric epithelium development GO:0072207 8.62 PAX2 WT1

Molecular functions related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.62 MAF WT1

Sources for Nephrogenic Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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