MCID: NPH006
MIFTS: 31

Nephrogenic Adenofibroma

Categories: Nephrological diseases, Cancer diseases

Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 12 15 73
Metanephric Adenofibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2698
NCIt 50 C39812
SNOMED-CT 68 128760004
UMLS 73 C1266141

Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to fallopian tube carcinosarcoma and childhood endodermal sinus tumor. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include kidney, and related phenotypes are Decreased sensitivity to paclitaxel and embryo

Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 fallopian tube carcinosarcoma 10.9 NCAM1 WT1
2 childhood endodermal sinus tumor 10.9 PAX2 PAX8
3 balloon cell malignant melanoma 10.9 KRT7 MME
4 endolymphatic sac tumor 10.9 KRT7 KRT8
5 ovarian large-cell neuroendocrine carcinoma 10.9 KRT7 NCAM1
6 cervix endometriosis 10.9 MME PAX2
7 plasma cell leukemia 10.9 MAF NCAM1
8 female reproductive endometrioid cancer 10.9 KRT7 WT1
9 sensory organ benign neoplasm 10.9 KRT7 NCAM1
10 renal pelvis adenocarcinoma 10.9 KRT7 PAX8
11 nephrogenic adenoma of urinary bladder 10.8 KRT7 PAX2 PAX8
12 endosalpingiosis 10.8 KRT7 PAX8 WT1
13 clear cell hidradenoma 10.8 MME PAX8
14 angioimmunoblastic t-cell lymphoma 10.8 MAF MME
15 bladder benign neoplasm 10.8 KRT7 PAX2 PAX8
16 nephrogenic adenoma 10.8 KRT7 PAX2 PAX8
17 extrahepatic bile duct adenocarcinoma 10.8 MME NCAM1
18 urethral diverticulum 10.8 KRT7 PAX8 WT1
19 hidrocystoma 10.8 KRT7 KRT8
20 endocervical adenocarcinoma 10.8 KRT7 PAX2 PAX8
21 neurenteric cyst 10.7 KRT18 KRT8
22 adenocarcinoma in situ 10.7 KRT7 PAX2 PAX8
23 ovarian cancer 1 10.7 KRT7 PAX8 WT1
24 angiokeratoma of fordyce 10.7 HBA1 WT1
25 malignant ovarian surface epithelial-stromal neoplasm 10.7 KRT7 PAX8 WT1
26 ovary epithelial cancer 10.7 KRT7 PAX8 WT1
27 wilms tumor 5 10.7 PAX2 PAX8 WT1
28 collecting duct carcinoma 10.7 KRT7 MME PAX8
29 rete testis adenoma 10.7 NCAM1 PAX2 PAX8
30 endocervical carcinoma 10.7 KRT7 PAX8
31 cystadenofibroma 10.7 KRT7 MME NCAM1
32 mixed endometrial stromal and smooth muscle tumor 10.7 CALD1 MME
33 apocrine sweat gland neoplasm 10.7 KRT7 KRT8
34 spermatocele 10.7 MME NCAM1 PAX2
35 metanephric adenoma 10.7 KRT18 KRT7 WT1
36 scleral staphyloma 10.6 NF1 PAX2
37 epithelioid trophoblastic tumor 10.6 KRT18 KRT7
38 malignant glandular tumor of peripheral nerve sheath 10.6 B3GAT1 NF1
39 gastric tubular adenocarcinoma 10.6 CHL1 KRT7 KRT8
40 adenoid squamous cell carcinoma 10.6 HBA1 KRT7
41 merkel cell carcinoma 10.6 KRT7 KRT8 NCAM1
42 proliferating trichilemmal cyst 10.6 KRT18 KRT7 KRT8
43 cutaneous adenocystic carcinoma 10.6 KRT18 KRT7 KRT8
44 pleomorphic carcinoma 10.6 KRT18 KRT7 KRT8
45 lymphoepithelioma-like carcinoma 10.6 KRT18 KRT7 KRT8
46 mammary paget's disease 10.5 KRT18 KRT7 KRT8
47 kidney rhabdoid cancer 10.5 B3GAT1 WT1
48 malignant leydig cell tumor 10.5 KRT7 MME
49 primary cutaneous amyloidosis 10.5 KRT18 KRT7 KRT8
50 adenosquamous carcinoma 10.5 KRT18 KRT7 KRT8

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to Nephrogenic Adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 WT1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 KRT18 KRT8 MYOG NF1 PAX2 PAX8
2 mortality/aging MP:0010768 9.47 B3GAT1 CA9 KRT18 KRT8 MAF MYOD1

Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

41
Kidney

Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

# Title Authors Year
1
Nephrogenic adenofibroma in a young child. ( 11156329 )
2000
2
Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )
1997
3
Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )
1992

Variations for Nephrogenic Adenofibroma

Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for Nephrogenic Adenofibroma

GO Terms for Nephrogenic Adenofibroma

Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
2 cell periphery GO:0071944 8.8 CD34 KRT18 KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 MYOD1 MYOG PAX2 PAX8 SS18 WT1
2 cornification GO:0070268 9.82 KRT18 KRT7 KRT8
3 kidney development GO:0001822 9.81 MME PAX8 WT1
4 skeletal muscle tissue development GO:0007519 9.71 MYOD1 MYOG NF1
5 branching involved in ureteric bud morphogenesis GO:0001658 9.67 PAX2 PAX8 WT1
6 positive regulation of myoblast fusion GO:1901741 9.64 MYOD1 MYOG
7 urogenital system development GO:0001655 9.63 PAX2 PAX8
8 mesonephros development GO:0001823 9.63 PAX2 PAX8
9 myotube differentiation GO:0014902 9.62 MYOD1 MYOG
10 hepatocyte apoptotic process GO:0097284 9.62 KRT18 KRT8
11 mesenchymal to epithelial transition GO:0060231 9.61 PAX2 WT1
12 positive regulation of skeletal muscle fiber development GO:0048743 9.61 MYOD1 MYOG
13 cellular response to gonadotropin stimulus GO:0071371 9.6 PAX8 WT1
14 metanephric mesenchyme development GO:0072075 9.59 PAX2 WT1
15 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.58 PAX2 PAX8
16 pronephros development GO:0048793 9.57 PAX2 PAX8
17 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.56 PAX2 PAX8
18 muscle cell fate commitment GO:0042693 9.55 MYOD1 MYOG
19 metanephric S-shaped body morphogenesis GO:0072284 9.52 PAX8 WT1
20 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX2 PAX8
21 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
22 metanephric distal convoluted tubule development GO:0072221 9.43 PAX2 PAX8
23 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
24 pronephric field specification GO:0039003 9.37 PAX2 PAX8
25 positive regulation of metanephric DCT cell differentiation GO:2000594 9.32 PAX2 PAX8
26 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX2 PAX8
27 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.16 PAX2 PAX8
28 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 8.96 PAX2 PAX8
29 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 MAF MYOD1 MYOG PAX2 PAX8 SS18

Molecular functions related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 CA9 CALD1 CHL1 HBA1 KRT18 KRT7

Sources for Nephrogenic Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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