MCID: NPH001
MIFTS: 30

Nephrogenic Adenoma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Nephrogenic Adenoma

MalaCards integrated aliases for Nephrogenic Adenoma:

Name: Nephrogenic Adenoma 12 15
Nephrogenic Metaplasia 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7334
NCIt 50 C97097
SNOMED-CT 67 78236000
UMLS 70 C0334039

Summaries for Nephrogenic Adenoma

MalaCards based summary : Nephrogenic Adenoma, also known as nephrogenic metaplasia, is related to nephrogenic adenoma of urinary bladder and nephrogenic adenoma of the urethra. An important gene associated with Nephrogenic Adenoma is AMACR (Alpha-Methylacyl-CoA Racemase), and among its related pathways/superpathways are FOXA1 transcription factor network and ID signaling pathway. Affiliated tissues include prostate, kidney and lymph node.

Wikipedia : 73 Nephrogenic adenoma is a benign growth typically found in the urinary... more...

Related Diseases for Nephrogenic Adenoma

Diseases related to Nephrogenic Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 nephrogenic adenoma of urinary bladder 32.0 PAX8 PAX2 KRT7 AMACR
2 nephrogenic adenoma of the urethra 31.5 PAX8 PAX2 KRT7 KLK3 AMACR
3 transitional cell carcinoma 30.6 TP63 KRT7 KLK3
4 urethral diverticulum 30.4 PAX8 KRT7 KLK3 AMACR
5 cystitis cystica 30.0 KRT7 KLK3
6 mucinous adenocarcinoma 30.0 MUC1 KRT7 AMACR
7 suppression of tumorigenicity 12 29.9 NKX3-1 KLK3 AMACR
8 glandular cystitis 29.8 MUC1 KRT7 AMACR
9 papillary adenoma 29.7 NAPSA KRT7 AMACR
10 clear cell adenocarcinoma 29.6 PAX8 PAX2 NAPSA KRT7 KLK3 AMACR
11 adenocarcinoma 29.6 NAPSA MUC1 KRT7 KLK3
12 prostatic acinar adenocarcinoma 29.2 PAX8 NKX3-1 KLK3 AMACR
13 adenoma 10.9
14 cystitis 10.5
15 urinary tract infection 10.4
16 acute cystitis 10.3
17 rete testis adenoma 10.3 PAX8 PAX2
18 chronic cystitis 10.3
19 ureterocele 10.3 PAX8 PAX2
20 epithelial predominant wilms' tumor 10.2 KRT7 AMACR
21 fallopian tube endometrioid adenocarcinoma 10.2 PAX8 PAX2
22 clear cell papillary renal cell carcinoma 10.2 KRT7 AMACR
23 chromophil adenoma of the kidney 10.2 KRT7 AMACR
24 hydronephrosis 10.2
25 epididymal neoplasm 10.2 PAX2 KRT7
26 mayer-rokitansky-kuster-hauser syndrome 10.2 TP63 PAX2
27 male urethral cancer 10.2 KLK3 AMACR
28 clear cell adenoma 10.2 S100A1 PAX8
29 urethra adenocarcinoma 10.2 KLK3 AMACR
30 necrotizing sialometaplasia 10.2 TP63 KRT7
31 urethra cancer 10.2 KLK3 AMACR
32 ovarian seromucinous carcinoma 10.2 PAX8 KRT7
33 renal pelvis adenocarcinoma 10.2 PAX8 KRT7
34 ovarian large-cell neuroendocrine carcinoma 10.2 PAX8 KRT7
35 kidney cortex disease 10.2 KRT7 AMACR
36 wolffian duct adenocarcinoma 10.2 PAX8 KRT7
37 uterus perivascular epithelioid cell tumor 10.2 PAX8 KRT7
38 clear cell hidradenoma 10.2 PAX8 KRT7
39 ovarian mucinous adenocarcinoma 10.2 KRT7 AMACR
40 bladder diverticulum 10.2
41 vesicoureteral reflux 1 10.2
42 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
43 urolithiasis 10.2
44 bladder urothelial carcinoma 10.2
45 ovarian mucinous neoplasm 10.2 PAX8 KRT7
46 eosinophilic variant of chromophobe renal cell carcinoma 10.2 S100A1 KRT7
47 thymus clear cell carcinoma 10.2 PAX8 KRT7
48 cystic basal cell carcinoma 10.2 TP63 KRT7
49 cribriform carcinoma 10.2 TP63 KRT7
50 prostate transitional cell carcinoma 10.2 KLK3 AMACR

Graphical network of the top 20 diseases related to Nephrogenic Adenoma:



Diseases related to Nephrogenic Adenoma

Symptoms & Phenotypes for Nephrogenic Adenoma

Drugs & Therapeutics for Nephrogenic Adenoma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenoma

Genetic Tests for Nephrogenic Adenoma

Anatomical Context for Nephrogenic Adenoma

MalaCards organs/tissues related to Nephrogenic Adenoma:

40
Prostate, Kidney, Lymph Node, Cervix

Publications for Nephrogenic Adenoma

Articles related to Nephrogenic Adenoma:

(show top 50) (show all 333)
# Title Authors PMID Year
1
Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications. 61
33674765 2021
2
Mimickers of Urothelial Carcinoma and the Approach to Differential Diagnosis. 61
33668963 2021
3
Clear Cell Adenocarcinoma in Men: A Series of 15 Cases. 61
32960833 2021
4
Tumour-like lesions of the urinary bladder. 61
33070959 2021
5
Nephrogenic adenoma of the prostate after laser therapy of benign prostatic hyperplasia. 61
33102080 2020
6
A Case Report of an Obstructing Ureteral Nephrogenic Adenoma in a Child Managed With Open Ileal Ureter. 61
32439556 2020
7
Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors. 61
32561332 2020
8
Additional Surgeries after Bladder Augmentation in Patients with Spina Bifida in the 21st Century. 61
31951496 2020
9
Nephrogenic adenoma of the bladder. A simulator of urothelial bladder neoplasia. 61
32164987 2020
10
Multifocal nephrogenic adenoma treated by intravesical sodium hyaluronate. 61
32565661 2020
11
Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up. 61
33123404 2020
12
Robot-assisted Laparoscopic Nephroureterectomy for a Nephrogenic Adenoma of Ureter. 61
31779773 2019
13
PAX8 positivity in nested variant of urothelial carcinoma: a potential diagnostic pitfall. 61
31669177 2019
14
Common and uncommon features of nephrogenic adenoma revisited. 61
31358481 2019
15
Mimickers of urothelial neoplasia. 61
30380401 2019
16
Rare Case of Primary Clear Cell Carcinoma of the Urinary Bladder. 61
31413434 2019
17
Nephrogenic Adenoma in the Setting of Refractory Labial Agglutination in an Elderly Woman. 61
29489552 2018
18
Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors. 61
29493186 2018
19
Clear cell adenocarcinoma of the urethra with inguinal lymph node metastases: A rare case report and review of literature. 61
29516944 2018
20
Ureteral Nephrogenic Adenoma in Chronic Recreational Ketamine Abuse. 61
29204356 2018
21
Fibromyxoid Nephrogenic Adenoma in the Ureter. 61
29984315 2018
22
Nephrogenic Adenoma Complicating Renal Transplantation: A Case Report and Discussion. 61
29198684 2017
23
Nephrogenic adenoma does not express NKX3.1. 61
28581204 2017
24
Microcystic transitional cell carcinoma: a rare tumor of the urinary bladder. 61
29154374 2017
25
Nephrogenic adenoma of the urinary tract: A 6-year single center experience. 61
28554748 2017
26
High-grade urothelial bladder cancer in children: A case report and critical analysis of the literature. 61
27752150 2016
27
Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy. 61
27909627 2016
28
Mixed Epithelial and Stromal Tumor of the Kidney: A Clinicopathologic Study of 53 Cases. 61
27635943 2016
29
Nephrogenic Adenoma: Clinical Features, Management, and Diagnostic Pitfalls. 61
27138263 2016
30
Nephrogenic adenoma arising in a complex circumferential urethral diverticulum of a female patient with a history of childhood neuroblastoma and chemotherapy. 61
27324755 2016
31
Nephrogenic adenoma in elderly patients: Three case reports. 61
27446559 2016
32
First-ever Reported Obstructing Ureteral Nephrogenic Adenoma in a Child and Subsequent Robotic-assisted Laparoscopic Ileal Ureter. 61
27001506 2016
33
Nephrogenic Adenoma of Female Urethra. 61
27172117 2016
34
Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications. 61
27040924 2016
35
Can We Identify Nephrogenic Adenoma in Urine Cytology Specimens? A Study Evaluating Previously Described Cytomorphologic Features in Correlation With PAX8 Immunohistochemical Staining Results. 61
27124920 2016
36
Fibromyxoid nephrogenic adenoma protruding in a renal cortical cyst. A rare morphological variant in an outstanding location. 61
26706600 2016
37
Histopathology and prognosis of de novo bladder tumors following solid organ transplantation. 61
25860378 2015
38
Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder. 61
26239299 2015
39
Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging. 61
26048699 2015
40
BK polyomavirus-infected nephrogenic adenoma of the urinary bladder in a renal transplant recipient: A case report. 61
26189101 2015
41
Diffuse and multifocal nephrogenic adenoma with Familial Mediterranean Fever: a case report with molecular study. 61
26428868 2015
42
Nephrogenic adenoma of the pediatric ureter. 61
25598138 2015
43
Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature. 61
27347540 2015
44
Do We Need Surveillance Urethro-Cystoscopy in Patients with Neurogenic Lower Urinary Tract Dysfunction? 61
26513149 2015
45
Distinguishing nested variants of urothelial carcinoma from benign mimickers by TERT promoter mutation. 61
25118812 2015
46
Clear cell adenocarcinoma of the urethra: review of the literature. 61
25685552 2015
47
Immunohistochemical staining characteristics of nephrogenic adenoma using the PIN-4 cocktail (p63, AMACR, and CK903) and GATA-3. 61
24921643 2014
48
Nephrogenic adenoma of the bladder associated with urinary tuberculosis. 61
25867159 2014
49
Nephrogenic adenoma in a urethral diverticulum. 61
25185615 2014
50
Indiana pouch in children: a 15-year experience. 61
24863986 2014

Variations for Nephrogenic Adenoma

Expression for Nephrogenic Adenoma

Search GEO for disease gene expression data for Nephrogenic Adenoma.

Pathways for Nephrogenic Adenoma

Pathways related to Nephrogenic Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.62 NKX3-1 KLK3
2 9.83 PAX8 PAX2

GO Terms for Nephrogenic Adenoma

Cellular components related to Nephrogenic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.26 TP63 S100A1 PAX2 KLK3
2 chromatin GO:0000785 9.02 TP63 PAX8 PAX2 NKX3-1 MUC1

Biological processes related to Nephrogenic Adenoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.9 TP63 PAX8 PAX2 NKX3-1
2 branching involved in ureteric bud morphogenesis GO:0001658 9.59 PAX8 PAX2
3 protein kinase B signaling GO:0043491 9.58 PAX2 NKX3-1
4 positive regulation of apoptotic signaling pathway GO:2001235 9.58 TP63 NKX3-1
5 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.57 PAX8 PAX2
6 prostate gland development GO:0030850 9.56 TP63 NKX3-1
7 mesonephros development GO:0001823 9.55 PAX8 PAX2
8 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.54 PAX8 PAX2
9 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.52 PAX8 PAX2
10 pronephros development GO:0048793 9.51 PAX8 PAX2
11 metanephric epithelium development GO:0072207 9.49 PAX8 PAX2
12 metanephric nephron tubule formation GO:0072289 9.48 PAX8 PAX2
13 metanephric distal convoluted tubule development GO:0072221 9.46 PAX8 PAX2
14 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.43 PAX8 PAX2
15 positive regulation of metanephric DCT cell differentiation GO:2000594 9.4 PAX8 PAX2
16 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX8 PAX2
17 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.32 PAX8 PAX2
18 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.26 PAX8 PAX2
19 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.16 PAX8 PAX2
20 pronephric field specification GO:0039003 8.96 PAX8 PAX2
21 urogenital system development GO:0001655 8.8 PAX8 PAX2 NKX3-1

Molecular functions related to Nephrogenic Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.46 TP63 PAX8 PAX2 NKX3-1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 TP63 PAX8 PAX2 NKX3-1 MUC1
3 transcription regulatory region sequence-specific DNA binding GO:0000976 8.92 TP63 PAX8 PAX2 NKX3-1

Sources for Nephrogenic Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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