NPHP15
MCID: NPH069
MIFTS: 43

Nephronophthisis 15 (NPHP15)

Categories: Genetic diseases, Liver diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nephronophthisis 15

MalaCards integrated aliases for Nephronophthisis 15:

Name: Nephronophthisis 15 57 12 72 29 13 6 15 70
Nphp15 57 12 72
Nephronophthisis, Type 15 39

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal recessive

Miscellaneous:
variable phenotype
four families have been reported (last curated october 2012)


HPO:

31
nephronophthisis 15:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:0111123
OMIM® 57 614845
OMIM Phenotypic Series 57 PS256100
MeSH 44 D052177
UMLS 70 C3541853

Summaries for Nephronophthisis 15

UniProtKB/Swiss-Prot : 72 Nephronophthisis 15: An autosomal recessive disorder characterized by the association of nephronophthisis with Leber congenital amaurosis and retinal degeneration, often resulting in blindness during childhood. Additional features include seizures, cerebellar vermis hypoplasia, facial dysmorphism, bronchiectasis and liver failure. Nephronophthisis is a chronic tubulo-interstitial nephritis that progresses to end- stage renal failure.

MalaCards based summary : Nephronophthisis 15, also known as nphp15, is related to joubert syndrome 24 and joubert syndrome 2. An important gene associated with Nephronophthisis 15 is CEP164 (Centrosomal Protein 164), and among its related pathways/superpathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. Affiliated tissues include liver, kidney and eye, and related phenotypes are nystagmus and global developmental delay

Disease Ontology : 12 A nephronophthisis that has material basis in homozygous or compound heterozygous mutation in the CEP164 gene on chromosome 11q.

More information from OMIM: 614845 PS256100

Related Diseases for Nephronophthisis 15

Diseases in the Nephronophthisis family:

Nephronophthisis 1 Nephronophthisis 2
Nephronophthisis 3 Nephronophthisis 4
Nephronophthisis 7 Nephronophthisis 11
Nephronophthisis 12 Nephronophthisis 9
Nephronophthisis 13 Nephronophthisis 14
Nephronophthisis 15 Nephronophthisis 16
Nephronophthisis 18 Nephronophthisis 19
Nephronophthisis 20 Infantile Nephronophthisis
Juvenile Nephronophthisis Late-Onset Nephronophthisis

Diseases related to Nephronophthisis 15 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 joubert syndrome 24 10.2 NPHP1 CEP164
2 joubert syndrome 2 10.2 NPHP1 C2CD3
3 cogan syndrome 10.2 NPHP4 NPHP1
4 joubert syndrome 15 10.2 NPHP4 NPHP1
5 meckel syndrome, type 2 10.2 NPHP4 NPHP1
6 nephronophthisis 4 10.2 NPHP4 NPHP1
7 meckel syndrome, type 5 10.2 NPHP4 NPHP1
8 tubulointerstitial kidney disease, autosomal dominant, 1 10.1 NPHP4 NPHP1
9 orofaciodigital syndrome i 10.1 RAB3IP CEP83 CEP164
10 cone-rod dystrophy 13 10.1 NPHP4 IQCB1
11 ciliopathy 10.1 SDCCAG8 NPHP4 C2CD3
12 leber congenital amaurosis 3 10.1 NPHP4 IQCB1
13 polycystic liver disease 1 with or without kidney cysts 10.1 NPHP4 NPHP1
14 bardet-biedl syndrome 6 10.1 SDCCAG8 INVS
15 spinocerebellar ataxia 11 10.0 SCLT1 CEP83 CEP164 C2CD3
16 orofaciodigital syndrome 10.0 SCLT1 CEP83 CEP164 C2CD3
17 bardet-biedl syndrome 1 10.0 SDCCAG8 NPHP4 NPHP1
18 joubert syndrome 5 10.0 NPHP1 IQCB1
19 joubert syndrome 4 9.9 NPHP4 NPHP1 IQCB1
20 joubert syndrome 8 9.9 NPHP3 NPHP1
21 bardet-biedl syndrome 14 9.9 SDCCAG8 IQCB1
22 retinal aplasia 9.8 SDCCAG8 NPHP4 NPHP1 IQCB1
23 end stage renal disease 9.8 NPHP4 NEK8 INVS
24 cranioectodermal dysplasia 9.8 NPHP4 NPHP1 IQCB1 INVS
25 caroli disease 9.7 NPHP3 NPHP1 INVS
26 eye disease 9.7 SDCCAG8 NPHP4 NPHP1 IQCB1
27 right atrial isomerism 9.7 NEK8 INVS
28 nephronophthisis 1 9.6 NPHP4 NPHP3 NPHP1 INVS
29 polycystic kidney disease 2 with or without polycystic liver disease 9.6 NPHP4 NEK9 NEK8 INVS
30 retinal degeneration 9.6 NPHP4 NPHP3 NPHP1 CEP164
31 meckel syndrome, type 3 9.6 NPHP4 NPHP3 NPHP1 INVS
32 cone-rod dystrophy 2 9.5 SCLT1 NPHP4 IQCB1 CEP83 C2CD3
33 meckel syndrome, type 4 9.4 NPHP4 NPHP3 NPHP1 IQCB1 CEP164
34 alstrom syndrome 9.4 NPHP3 NEK9 IQCB1 INVS
35 polycystic kidney disease 9.4 ZNF423 NPHP3 NEK8 INVS
36 coloboma of macula 9.4 SCLT1 NPHP4 NPHP3 NPHP1 IQCB1
37 joubert syndrome 3 9.3 NPHP4 NPHP3 NPHP1 IQCB1 INVS
38 kidney disease 9.3 ZNF423 NPHP4 NPHP3 NPHP1 NEK8
39 coach syndrome 1 9.2 SDCCAG8 NPHP4 NPHP3 NPHP1 IQCB1 C2CD3
40 infantile nephronophthisis 9.1 ZNF423 NPHP4 NPHP3 NEK8 INVS CEP83
41 nephronophthisis 19 9.1 NPHP4 NPHP3 NPHP1 IQCB1 INVS GLIS2
42 cystic kidney disease 9.0 NPHP4 NPHP3 NPHP1 NEK9 NEK8 INVS
43 juvenile nephronophthisis 9.0 NPHP4 NPHP3 NPHP1 IQCB1 INVS GLIS2
44 meckel syndrome, type 6 9.0 NPHP4 NPHP3 NPHP1 NEK9 IQCB1 INVS
45 renal-hepatic-pancreatic dysplasia 8.9 SDCCAG8 NPHP4 NPHP3 NPHP1 NEK8 IQCB1
46 leber plus disease 8.9 SDCCAG8 RAB3IP NPHP4 NPHP3 NPHP1 IQCB1
47 visceral heterotaxy 8.7 NPHP4 NPHP3 NPHP1 NEK9 NEK8 IQCB1
48 nephronophthisis 11 8.6 SDCCAG8 NPHP4 NPHP3 NPHP1 NEK9 NEK8
49 kartagener syndrome 8.6 SDCCAG8 NPHP4 NPHP3 NPHP1 NEK9 NEK8
50 nephronophthisis 14 8.6 ZNF423 NPHP4 NPHP3 NPHP1 NEK9 NEK8

Graphical network of the top 20 diseases related to Nephronophthisis 15:



Diseases related to Nephronophthisis 15

Symptoms & Phenotypes for Nephronophthisis 15

Human phenotypes related to Nephronophthisis 15:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 nystagmus 31 occasional (7.5%) HP:0000639
2 global developmental delay 31 occasional (7.5%) HP:0001263
3 blindness 31 occasional (7.5%) HP:0000618
4 obesity 31 occasional (7.5%) HP:0001513
5 hepatic failure 31 occasional (7.5%) HP:0001399
6 cerebellar vermis hypoplasia 31 occasional (7.5%) HP:0001320
7 polydactyly 31 occasional (7.5%) HP:0010442
8 seizure 31 occasional (7.5%) HP:0001250
9 nephronophthisis 31 HP:0000090
10 retinal degeneration 31 HP:0000546

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Genitourinary Kidneys:
nephronophthisis

Neurologic Central Nervous System:
seizures (in 1 patient)
developmental delay (in 1 patient)
cerebellar vermis hypoplasia (in 1 patient)

Abdomen Liver:
liver failure (in some patients)

Head And Neck Eyes:
retinal degeneration
blindness (in some patients)
leber congenital amaurosis
nystagmus (in 1 patient)

Growth Weight:
obesity (in some patients)

Skeletal Hands:
polydactyly (in 1 patient)

Clinical features from OMIM®:

614845 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Nephronophthisis 15:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 C2CD3 CEP164 GLIS2 INVS NEK8 NEK9
2 mortality/aging MP:0010768 9.73 C2CD3 CEP164 CEP83 GLIS2 INVS IQCB1
3 renal/urinary system MP:0005367 9.23 GLIS2 INVS NEK8 NPHP1 NPHP3 NPHP4

Drugs & Therapeutics for Nephronophthisis 15

Search Clinical Trials , NIH Clinical Center for Nephronophthisis 15

Genetic Tests for Nephronophthisis 15

Genetic tests related to Nephronophthisis 15:

# Genetic test Affiliating Genes
1 Nephronophthisis 15 29 CEP164

Anatomical Context for Nephronophthisis 15

MalaCards organs/tissues related to Nephronophthisis 15:

40
Liver, Kidney, Eye

Publications for Nephronophthisis 15

Articles related to Nephronophthisis 15:

# Title Authors PMID Year
1
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. 57 6
22863007 2012
2
Embryonic and foetal expression patterns of the ciliopathy gene CEP164. 61
31990917 2020
3
Genetic and clinical characterization of Pakistani families with Bardet-Biedl syndrome extends the genetic and phenotypic spectrum. 61
27708425 2016
4
Mutations of CEP83 cause infantile nephronophthisis and intellectual disability. 61
24882706 2014

Variations for Nephronophthisis 15

ClinVar genetic disease variations for Nephronophthisis 15:

6 (show top 50) (show all 304)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CEP164 NM_014956.5(CEP164):c.4381T>C (p.Ter1461Arg) SNV Pathogenic 37294 rs1565649749 GRCh37: 11:117282882-117282882
GRCh38: 11:117412166-117412166
2 CEP164 NM_014956.5(CEP164):c.32A>C (p.Gln11Pro) SNV Pathogenic 37295 rs387907309 GRCh37: 11:117209334-117209334
GRCh38: 11:117338618-117338618
3 CEP164 NM_014956.5(CEP164):c.277C>T (p.Arg93Trp) SNV Pathogenic 37296 rs387907310 GRCh37: 11:117222588-117222588
GRCh38: 11:117351872-117351872
4 CEP164 NM_014956.5(CEP164):c.1573C>T (p.Gln525Ter) SNV Pathogenic 37297 rs387907311 GRCh37: 11:117252580-117252580
GRCh38: 11:117381864-117381864
5 CEP164 NM_014956.5(CEP164):c.1726C>T (p.Arg576Ter) SNV Pathogenic 37298 rs145646425 GRCh37: 11:117257920-117257920
GRCh38: 11:117387204-117387204
6 CEP164 NM_014956.5(CEP164):c.2689C>T (p.Arg897Ter) SNV Pathogenic 571715 rs764893412 GRCh37: 11:117265138-117265138
GRCh38: 11:117394422-117394422
7 CEP164 NM_014956.5(CEP164):c.1A>T (p.Met1Leu) SNV Pathogenic 1027912 GRCh37: 11:117209303-117209303
GRCh38: 11:117338587-117338587
8 CEP164 NM_014956.5(CEP164):c.3997C>T (p.Gln1333Ter) SNV Pathogenic 1027913 GRCh37: 11:117280582-117280582
GRCh38: 11:117409866-117409866
9 CEP164 NM_014956.5(CEP164):c.1409+10G>A SNV Pathogenic 473078 rs199783386 GRCh37: 11:117251431-117251431
GRCh38: 11:117380715-117380715
10 CEP164 NM_014956.5(CEP164):c.4286+1G>T SNV Pathogenic 992430 GRCh37: 11:117282634-117282634
GRCh38: 11:117411918-117411918
11 CEP164 NM_014956.5(CEP164):c.2992C>T (p.Arg998Ter) SNV Pathogenic 992429 GRCh37: 11:117266341-117266341
GRCh38: 11:117395625-117395625
12 CEP164 NM_014956.5(CEP164):c.381dup (p.Lys128fs) Duplication Pathogenic 581067 rs747914869 GRCh37: 11:117222685-117222686
GRCh38: 11:117351969-117351970
13 CEP164 NM_014956.5(CEP164):c.347del (p.Lys116fs) Deletion Likely pathogenic 993033 GRCh37: 11:117222648-117222648
GRCh38: 11:117351932-117351932
14 CEP164 NM_014956.5(CEP164):c.2493+1G>A SNV Likely pathogenic 578474 rs778819060 GRCh37: 11:117263344-117263344
GRCh38: 11:117392628-117392628
15 CEP164 NM_014956.5(CEP164):c.2562del (p.Met854fs) Deletion Likely pathogenic 634610 rs1565582604 GRCh37: 11:117263788-117263788
GRCh38: 11:117393072-117393072
16 CEP164 NM_014956.5(CEP164):c.276T>G (p.Tyr92Ter) SNV Likely pathogenic 930259 GRCh37: 11:117222587-117222587
GRCh38: 11:117351871-117351871
17 CEP164 NM_014956.5(CEP164):c.4228C>T (p.Gln1410Ter) SNV Conflicting interpretations of pathogenicity 281163 rs147398904 GRCh37: 11:117282575-117282575
GRCh38: 11:117411859-117411859
18 CEP164 NM_014956.5(CEP164):c.4060G>A (p.Asp1354Asn) SNV Uncertain significance 569863 rs200520898 GRCh37: 11:117280645-117280645
GRCh38: 11:117409929-117409929
19 CEP164 NM_014956.5(CEP164):c.548T>A (p.Met183Lys) SNV Uncertain significance 573184 rs144206271 GRCh37: 11:117232705-117232705
GRCh38: 11:117361989-117361989
20 CEP164 NM_014956.5(CEP164):c.2784G>T (p.Glu928Asp) SNV Uncertain significance 641654 rs143446218 GRCh37: 11:117265659-117265659
GRCh38: 11:117394943-117394943
21 CEP164 NM_014956.5(CEP164):c.815A>G (p.Asp272Gly) SNV Uncertain significance 645065 rs1411607770 GRCh37: 11:117241845-117241845
GRCh38: 11:117371129-117371129
22 CEP164 NM_014956.5(CEP164):c.3107C>T (p.Ala1036Val) SNV Uncertain significance 473082 rs1264586687 GRCh37: 11:117266787-117266787
GRCh38: 11:117396071-117396071
23 CEP164 NM_014956.5(CEP164):c.3001C>G (p.Leu1001Val) SNV Uncertain significance 429616 rs199637319 GRCh37: 11:117266350-117266350
GRCh38: 11:117395634-117395634
24 CEP164 NC_000011.10:g.(?_117407925)_(117412168_?)del Deletion Uncertain significance 831428 GRCh37: 11:117278641-117282884
GRCh38:
25 CEP164 NM_014956.5(CEP164):c.3519T>A (p.Asp1173Glu) SNV Uncertain significance 834179 GRCh37: 11:117278658-117278658
GRCh38: 11:117407942-117407942
26 CEP164 NM_014956.5(CEP164):c.2362G>A (p.Val788Met) SNV Uncertain significance 834744 GRCh37: 11:117263212-117263212
GRCh38: 11:117392496-117392496
27 CEP164 NM_014956.5(CEP164):c.1810G>A (p.Glu604Lys) SNV Uncertain significance 835860 GRCh37: 11:117258004-117258004
GRCh38: 11:117387288-117387288
28 CEP164 NM_014956.5(CEP164):c.2870A>T (p.Gln957Leu) SNV Uncertain significance 836608 GRCh37: 11:117265864-117265864
GRCh38: 11:117395148-117395148
29 CEP164 NM_014956.5(CEP164):c.2858G>A (p.Arg953Gln) SNV Uncertain significance 837753 GRCh37: 11:117265852-117265852
GRCh38: 11:117395136-117395136
30 CEP164 NM_014956.5(CEP164):c.796_798AAG[1] (p.Lys267del) Microsatellite Uncertain significance 838418 GRCh37: 11:117241824-117241826
GRCh38: 11:117371108-117371110
31 CEP164 NM_014956.5(CEP164):c.3741G>T (p.Gln1247His) SNV Uncertain significance 838715 GRCh37: 11:117279737-117279737
GRCh38: 11:117409021-117409021
32 CEP164 NM_014956.5(CEP164):c.4355A>G (p.His1452Arg) SNV Uncertain significance 841686 GRCh37: 11:117282856-117282856
GRCh38: 11:117412140-117412140
33 CEP164 NM_014956.5(CEP164):c.3483G>A (p.Met1161Ile) SNV Uncertain significance 841957 GRCh37: 11:117268011-117268011
GRCh38: 11:117397295-117397295
34 CEP164 NM_014956.5(CEP164):c.3866C>T (p.Ser1289Leu) SNV Uncertain significance 842182 GRCh37: 11:117280451-117280451
GRCh38: 11:117409735-117409735
35 CEP164 NM_014956.5(CEP164):c.3944A>G (p.Tyr1315Cys) SNV Uncertain significance 842347 GRCh37: 11:117280529-117280529
GRCh38: 11:117409813-117409813
36 CEP164 NM_014956.5(CEP164):c.901C>T (p.Arg301Ter) SNV Uncertain significance 501891 rs780849567 GRCh37: 11:117241931-117241931
GRCh38: 11:117371215-117371215
37 CEP164 NM_014956.5(CEP164):c.2206G>A (p.Glu736Lys) SNV Uncertain significance 844430 GRCh37: 11:117261854-117261854
GRCh38: 11:117391138-117391138
38 CEP164 NM_014956.5(CEP164):c.966G>C (p.Lys322Asn) SNV Uncertain significance 845169 GRCh37: 11:117241996-117241996
GRCh38: 11:117371280-117371280
39 CEP164 NM_014956.5(CEP164):c.1144G>A (p.Ala382Thr) SNV Uncertain significance 846799 GRCh37: 11:117242174-117242174
GRCh38: 11:117371458-117371458
40 CEP164 NM_014956.5(CEP164):c.1474G>A (p.Glu492Lys) SNV Uncertain significance 847670 GRCh37: 11:117252481-117252481
GRCh38: 11:117381765-117381765
41 CEP164 NM_014956.5(CEP164):c.3371T>C (p.Met1124Thr) SNV Uncertain significance 848288 GRCh37: 11:117267899-117267899
GRCh38: 11:117397183-117397183
42 CEP164 NM_014956.5(CEP164):c.1666G>A (p.Ala556Thr) SNV Uncertain significance 848293 GRCh37: 11:117253600-117253600
GRCh38: 11:117382884-117382884
43 CEP164 NM_014956.5(CEP164):c.4025C>T (p.Pro1342Leu) SNV Uncertain significance 848910 GRCh37: 11:117280610-117280610
GRCh38: 11:117409894-117409894
44 CEP164 NM_014956.5(CEP164):c.1480C>T (p.Pro494Ser) SNV Uncertain significance 849046 GRCh37: 11:117252487-117252487
GRCh38: 11:117381771-117381771
45 CEP164 NM_014956.5(CEP164):c.1982G>A (p.Arg661Gln) SNV Uncertain significance 849481 GRCh37: 11:117261540-117261540
GRCh38: 11:117390824-117390824
46 CEP164 NM_014956.5(CEP164):c.3605A>T (p.Glu1202Val) SNV Uncertain significance 849788 GRCh37: 11:117278744-117278744
GRCh38: 11:117408028-117408028
47 CEP164 NM_014956.5(CEP164):c.4140C>T (p.Ser1380=) SNV Uncertain significance 850853 GRCh37: 11:117281587-117281587
GRCh38: 11:117410871-117410871
48 CEP164 NM_014956.5(CEP164):c.2283+2T>C SNV Uncertain significance 851066 GRCh37: 11:117261933-117261933
GRCh38: 11:117391217-117391217
49 CEP164 NM_014956.5(CEP164):c.1152A>G (p.Gln384=) SNV Uncertain significance 851371 GRCh37: 11:117242182-117242182
GRCh38: 11:117371466-117371466
50 CEP164 NM_014956.5(CEP164):c.2339C>T (p.Ser780Leu) SNV Uncertain significance 851372 GRCh37: 11:117262997-117262997
GRCh38: 11:117392281-117392281

UniProtKB/Swiss-Prot genetic disease variations for Nephronophthisis 15:

72
# Symbol AA change Variation ID SNP ID
1 CEP164 p.Gln11Pro VAR_068503 rs387907309
2 CEP164 p.Arg93Trp VAR_068504 rs387907310

Expression for Nephronophthisis 15

Search GEO for disease gene expression data for Nephronophthisis 15.

Pathways for Nephronophthisis 15

GO Terms for Nephronophthisis 15

Cellular components related to Nephronophthisis 15 according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.29 SDCCAG8 SCLT1 RAB3IP NPHP4 NPHP1 NEK9
2 cytosol GO:0005829 10.24 SDCCAG8 SCLT1 RAB3IP NPHP4 NPHP3 NPHP1
3 cell projection GO:0042995 9.97 SDCCAG8 RAB3IP NPHP4 NPHP3 NPHP1 NEK8
4 microtubule organizing center GO:0005815 9.81 SDCCAG8 NPHP4 NEK8 IQCB1
5 cilium GO:0005929 9.8 NPHP4 NPHP3 NPHP1 NEK8 IQCB1 INVS
6 ciliary basal body GO:0036064 9.76 SDCCAG8 RAB3IP NPHP4 C2CD3
7 cell-cell junction GO:0005911 9.7 SDCCAG8 NPHP4 NPHP1
8 cytoskeleton GO:0005856 9.7 SDCCAG8 SCLT1 RAB3IP NPHP4 NPHP1 NEK8
9 centriole GO:0005814 9.63 SDCCAG8 SCLT1 IQCB1 CEP83 CEP164 C2CD3
10 photoreceptor connecting cilium GO:0032391 9.61 NPHP4 NPHP1 IQCB1
11 ciliary base GO:0097546 9.55 NPHP4 NEK8
12 non-motile cilium GO:0097730 9.54 NPHP4 GLIS2
13 ciliary transition fiber GO:0097539 9.43 SCLT1 CEP83 CEP164
14 ciliary inversin compartment GO:0097543 9.4 NEK8 INVS
15 centrosome GO:0005813 9.28 SDCCAG8 SCLT1 RAB3IP NPHP4 NEK9 NEK8

Biological processes related to Nephronophthisis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of canonical Wnt signaling pathway GO:0090090 9.63 NPHP4 NPHP3 INVS
2 cell projection organization GO:0030030 9.63 SDCCAG8 NPHP1 IQCB1 CEP83 CEP164 C2CD3
3 cilium assembly GO:0060271 9.56 ZNF423 SCLT1 RAB3IP NPHP3 IQCB1 CEP83
4 protein localization to centrosome GO:0071539 9.43 CEP83 C2CD3
5 photoreceptor cell maintenance GO:0045494 9.43 NPHP4 NPHP3 IQCB1
6 positive regulation of bicellular tight junction assembly GO:1903348 9.4 NPHP4 NPHP1
7 maintenance of animal organ identity GO:0048496 9.37 NPHP3 IQCB1
8 visual behavior GO:0007632 9.32 NPHP4 NPHP1
9 ciliary basal body-plasma membrane docking GO:0097711 9.28 SDCCAG8 SCLT1 RAB3IP NPHP4 NPHP1 IQCB1

Molecular functions related to Nephronophthisis 15 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 ZNF423 SDCCAG8 SCLT1 RAB3IP NPHP4 NPHP3

Sources for Nephronophthisis 15

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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