MCID: NPH010
MIFTS: 50

Nephrosclerosis

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Nephrosclerosis

MalaCards integrated aliases for Nephrosclerosis:

Name: Nephrosclerosis 12 74 20 54 44 15 17 71
Renal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11664
ICD9CM 34 587
MeSH 44 D009400
SNOMED-CT 67 194773000
ICD10 32 I12
UMLS 71 C0027719

Summaries for Nephrosclerosis

MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to malignant hypertension and proteinuria, chronic benign. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are TGF-Beta Pathway and p70S6K Signaling. The drugs Angiotensin II and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high... more...

Related Diseases for Nephrosclerosis

Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 31.1 AGTR1 ADAMTS13 ACE
2 proteinuria, chronic benign 30.8 VEGFA SYNPO NPHS2 NPHS1 AGTR1 ACE
3 hypertensive nephropathy 30.7 VEGFA AGTR1 ACE
4 pyelonephritis 30.6 TNF CCL2 ACE
5 nephrotic syndrome 30.6 SYNPO NPHS2 NPHS1 ACE
6 microvascular complications of diabetes 3 30.4 TGFB1 NPHS1 INS CCN2 AGTR1 ACE
7 uremia 30.4 TNF INS ACE
8 glomerulonephritis 30.4 TGFB1 NPHS2 NPHS1 MPO CCN2 CCL2
9 rapidly progressive glomerulonephritis 30.3 TGFB1 NPHS1 MPO
10 arteriosclerosis 30.3 INS HIF1A F3 CCL2 ACE
11 hypertensive heart disease 30.2 NR3C2 AGTR1 ACE
12 thrombotic microangiopathy 30.2 VEGFA F3 ADAMTS13
13 iga glomerulonephritis 30.1 TGFB1 NPHS2 NPHS1 CCL2 AGTR1 ACE
14 vesicoureteral reflux 1 30.0 TGFB1 AGTR1 ACE
15 brucellosis 29.9 TNF TGFB1 MPO
16 focal segmental glomerulosclerosis 29.9 TNF TGFB1 SYNPO NPHS2 NPHS1 CCL2
17 end stage renal disease 29.9 VEGFA TNF TGFB1 NPHS2 NPHS1 MTHFR
18 pulmonary edema 29.8 TNF HIF1A AGTR1 ACE
19 proteasome-associated autoinflammatory syndrome 1 29.8 TNF MPO INS CCL2
20 membranous nephropathy 29.7 TNF NPHS2 NPHS1 MPO ACE
21 systemic scleroderma 29.7 TNF TGFB1 INS CCN2 ACE
22 ureteral obstruction 29.7 TGFB1 NR3C2 BMP7 AGTR1
23 deficiency anemia 29.6 TNF INS HIF1A ADAMTS13 ACE
24 peripheral vascular disease 29.6 VEGFA MTHFR F3 CCL2 ACE
25 disseminated intravascular coagulation 29.6 TNF F3 ADAMTS13
26 renal hypertension 29.6 NR3C2 NPHS1 AGTR1 ACE2 ACE
27 microvascular complications of diabetes 5 29.5 VEGFA INS HIF1A CCN2 AGTR1 ACE
28 hypertensive retinopathy 29.5 VEGFA NR3C2 AGTR1 ADAMTS13 ACE
29 autosomal dominant polycystic kidney disease 29.4 VEGFA TNF TGFB1 INS CCL2 AGTR1
30 anuria 29.4 NR3C2 F3 AGTR1 ADAMTS13 ACE
31 renal fibrosis 29.2 TNF TGFB1 NR3C2 HIF1A CCN2 CCL2
32 atherosclerosis susceptibility 29.1 VEGFA TNF MTHFR MPO INS F3
33 polycystic kidney disease 29.1 VEGFA TNF TGFB1 INS HIF1A CCL2
34 vascular disease 28.9 VEGFA TNF TGFB1 MTHFR MPO INS
35 liver cirrhosis 28.8 VEGFA TNF TGFB1 INS F3 CCN2
36 kidney disease 28.5 VEGFA TNF TGFB1 NR3C2 NPHS2 NPHS1
37 chronic kidney disease 28.1 VEGFA TNF TGFB1 NR3C2 NPHS2 NPHS1
38 hypertension, essential 28.0 VEGFA TNF TGFB1 NR3C2 NPHS2 NPHS1
39 diabetes mellitus 27.6 VEGFA TNF TGFB1 NR3C2 MTHFR MPO
40 lacrimoauriculodentodigital syndrome 10.9
41 arteritic anterior ischemic optic neuropathy 10.5 MTHFR ACE
42 genetic nephrotic syndrome 10.4 NPHS2 NPHS1
43 fibromuscular dysplasia 10.4 TGFB1 AGTR1 ACE
44 hemifacial spasm 10.4 VEGFA MTHFR
45 multiple cranial nerve palsy 10.4 MPO ACE
46 fuchs' heterochromic uveitis 10.4 CCL2 ACE
47 diffuse scleroderma 10.4 TGFB1 CCN2 ACE
48 urinary tract infection 10.4 TGFB1 ACE
49 diffuse mesangial sclerosis 10.3 TGFB1 NPHS2 NPHS1
50 anterior scleritis 10.3 TNF ACE

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Heart Disease
Hydronephrosis Hypertension, Essential
Kidney Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis

Symptoms & Phenotypes for Nephrosclerosis

MGI Mouse Phenotypes related to Nephrosclerosis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 ACE ACE2 ADRB1 AGTR1 BMP7 CCN2
2 homeostasis/metabolism MP:0005376 10.41 ACE ACE2 ADAMTS13 ADRB1 AGTR1 CCN2
3 growth/size/body region MP:0005378 10.39 ACE ACE2 ADRB1 AGTR1 BMP7 CCN2
4 mortality/aging MP:0010768 10.32 ACE ACE2 ADAMTS13 ADRB1 AGTR1 BMP7
5 hematopoietic system MP:0005397 10.31 ACE ACE2 ADAMTS13 AGTR1 BMP7 F3
6 immune system MP:0005387 10.27 ACE ACE2 ADAMTS13 AGTR1 BMP7 CCL2
7 embryo MP:0005380 10.18 ACE BMP7 CCN2 F3 HIF1A INS
8 digestive/alimentary MP:0005381 10.14 ACE2 BMP7 CCN2 HIF1A INS TGFB1
9 integument MP:0010771 10.13 ACE2 BMP7 CCN2 F3 HIF1A INS
10 nervous system MP:0003631 10.07 ACE AGTR1 BMP7 F3 HIF1A INS
11 muscle MP:0005369 10.02 ACE2 ADRB1 F3 HIF1A INS MPO
12 liver/biliary system MP:0005370 10.01 ACE CCN2 HIF1A INS MTHFR TGFB1
13 renal/urinary system MP:0005367 9.93 ACE ACE2 AGTR1 BMP7 HIF1A INS
14 respiratory system MP:0005388 9.56 ACE2 BMP7 CCN2 F3 HIF1A TGFB1
15 vision/eye MP:0005391 9.4 ACE ACE2 ADAMTS13 BMP7 CCN2 F3

Drugs & Therapeutics for Nephrosclerosis

Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3 Antihypertensive Agents Phase 4
4 Angiotensin Receptor Antagonists Phase 4
5 Giapreza Phase 4
6 Angiotensin II Type 1 Receptor Blockers Phase 4
7 Angiotensinogen Phase 4
8
Amlodipine Approved Phase 3 88150-42-9 2162
9
Ramipril Approved Phase 3 87333-19-5 5362129
10
Metoprolol Approved, Investigational Phase 3 51384-51-1, 37350-58-6 4171
11
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5280427 5282411
12 Tezosentan Investigational Phase 2, Phase 3 180384-57-0
13 Beraprost Investigational Phase 2, Phase 3 88430-50-6
14 Angiotensin-Converting Enzyme Inhibitors Phase 3
15 Adrenergic Antagonists Phase 3
16 Sympatholytics Phase 3
17 Adrenergic beta-Antagonists Phase 3
18 1,4-dihydropyridine Phase 3
19 Adrenergic beta-1 Receptor Antagonists Phase 3
20 Adrenergic Agents Phase 3
21 Neurotransmitter Agents Phase 3
22 Hormones Phase 3
23 Calcium, Dietary Phase 3
24 HIV Protease Inhibitors Phase 3
25 Vasodilator Agents Phase 3
26
protease inhibitors Phase 3
27 calcium channel blockers Phase 3
28 Anti-Arrhythmia Agents Phase 3
29 Platelet Aggregation Inhibitors Phase 2, Phase 3
30
Calcium Nutraceutical Phase 3 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aldosterone Breakthrough During Diovan (Valsartan), Tekturna (Aliskiren), and Combination (Valsartan+Aliskiren) Anti-hypertensive Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
2 African American Study of Kidney Disease and Hypertension Completed NCT04364139 Phase 3 Ramipril;Amlodipine;Metoprolol
3 TRK-100STP PhaseIIb/III Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

Anatomical Context for Nephrosclerosis

MalaCards organs/tissues related to Nephrosclerosis:

40
Kidney, Pituitary, Endothelial, Brain, Smooth Muscle, Pancreas, Prostate

Publications for Nephrosclerosis

Articles related to Nephrosclerosis:

(show top 50) (show all 1441)
# Title Authors PMID Year
1
[Profibrotic effects of aldosterone]. 54 61
15366722 2004
2
Collagen I upregulates extracellular matrix gene expression and secretion of TGF-beta 1 by cultured human mesangial cells. 54 61
14761892 2004
3
ACE inhibition is effective and renoprotective in hypertensive nephrosclerosis: the African American Study of Kidney Disease and Hypertension (AASK) trial. 54 61
12864879 2003
4
[Nephropathy associated with arterial hypertension: genes and Barker's hypothesis]. 61 54
12439839 2002
5
ACE inhibitors and appearance of renal events in hypertensive nephrosclerosis. 54 61
11566948 2001
6
Chronic proteinuric nephropathies: outcomes and response to treatment in a prospective cohort of 352 patients with different patterns of renal injury. 61 54
10845831 2000
7
Hypertension-induced organ damage in African Americans: transforming growth factor-beta(1) excess as a mechanism for increased prevalence. 54 61
10981147 2000
8
1,25-dihydroxyvitamin D3 stimulates transforming growth factor-beta1 synthesis by mouse renal proximal tubular cells. 54 61
10394107 1999
9
Effects of quinapril hydrochloride in patients with essential hypertension and impaired renal function. 61 54
9140710 1997
10
Short-term effects of blood pressure control and antihypertensive drug regimen on glomerular filtration rate: the African-American Study of Kidney Disease and Hypertension Pilot Study. 61 54
9159306 1997
11
Significance of increased accumulation of type VI collagen and transforming growth factor beta 1 in tubulointerstitial damage in hypertensive nephrosclerosis: an immunohistochemical study. 54 61
8737230 1996
12
Reversible renal insufficiency due to angiotensin converting enzyme inhibitors in hypertensive nephrosclerosis. 61 54
1883120 1991
13
Clinical Outcomes after Endovascular Therapy Among Hemodialysis Patients with Peripheral Artery Disease Stratified by the Primary Kidney Disease. 61
33418070 2021
14
Hypertensive nephrosclerosis: wider kidney biopsy indications may be needed to improve diagnostics. 61
32613703 2021
15
Kidney microRNA-21 Expression and Kidney Function in IgA Nephropathy. 61
33604541 2021
16
Association between thrombotic microangiopathy and activated alternative complement pathway in malignant nephrosclerosis. 61
33367879 2020
17
Prostacyclin analogue beraprost sodium efficacy in primary glomerular disease or nephrosclerosis: Analysis of the Japanese subgroup in CASSIOPEIR Study. 61
33340238 2020
18
Nephronophthisis in Young Adults Phenocopying Thrombotic Microangiopathy and Severe Nephrosclerosis. 61
33268504 2020
19
[Very-old deceased donors in kidney transplantation: How far can we go?] 61
33203614 2020
20
Larger Nephron Size and Nephrosclerosis Predict Progressive CKD and Mortality after Radical Nephrectomy for Tumor and Independent of Kidney Function. 61
32938650 2020
21
Peritubular Capillary Rarefaction: An Underappreciated Regulator of CKD Progression. 61
33158122 2020
22
Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKAy mice. 61
32939821 2020
23
Senior-Løken syndrome misdiagnosed as nephrosclerosis related to hypertensive disorders of pregnancy. 61
33109693 2020
24
Progressive Nephron Loss in Aging Kidneys: Clinical-Structural Associations Investigated by Two Anatomical Methods. 61
31599090 2020
25
Chronic kidney disease caused by maternally inherited diabetes and deafness: a case report. 61
33125665 2020
26
Performance of the Kidney Failure Risk Equation by Disease Etiology in Advanced CKD. 61
32928746 2020
27
Postoperative complications and perioperative management in patients on hemodialysis undergoing lung resection. 61
32989668 2020
28
Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea. 61
32784355 2020
29
Immune checkpoint inhibitor therapy-associated graft intolerance syndrome in a failed kidney transplant recipient. 61
32976688 2020
30
Stimulation of Structural and Functional Recovery of the Kidney in Rats with Postischemic Acute Renal Failure of Different Severity by Embryonic Protein-Peptide Complex Therapy. 61
32990849 2020
31
Time-averaged proteinuria during follow-up and renal prognosis in patients with biopsy-proven benign nephrosclerosis. 61
32274596 2020
32
Hypertensive nephropathy: a major roadblock hindering the advance of precision nephrology. 61
32897275 2020
33
Pharmacokinetics of dasatinib in a hemodialysis patient with chronic myeloid leukemia and chronic kidney disease. 61
32152879 2020
34
Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes. 61
32487559 2020
35
Gerontolizing Nephrology: Spectrum of Histopathological Findings of Kidney Biopsy in the Elderly. 61
33273792 2020
36
Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. 61
32639002 2020
37
The role of complement in arterial hypertension and hypertensive end organ damage. 61
32585035 2020
38
Clinical value of multiorgan damage in hypertensive crises: A prospective follow-up study. 61
32271999 2020
39
Correlations Between Interleukin-11 Expression and Hypertensive Kidney Injury in a Rat Model of Renovascular Hypertension. 61
31840157 2020
40
Current Trends on Glomerulosclerosis Regression. 61
32728402 2020
41
Premature vascular disease in young adult stroke: a pathology-based case series. 61
31853711 2020
42
Mortality patterns in patients with diabetes mellitus at a Nigerian tertiary hospital: A 10-Year autopsy study. 61
32295937 2020
43
Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis. 61
32154455 2020
44
Pathogenesis of Fabry nephropathy: The pathways leading to fibrosis. 61
31718986 2020
45
Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis. 61
32019582 2020
46
Kidney Structural Features from Living Donors Predict Graft Failure in the Recipient. 61
31974271 2020
47
Re: Larger Nephron Size, Low Nephron Number, and Nephrosclerosis on Biopsy as Predictors of Kidney Function after Donating a Kidney. 61
31671017 2020
48
Effects of Sustained-Release Beraprost in Patients With Primary Glomerular Disease or Nephrosclerosis: CASSIOPEIR Study Results. 61
31119846 2020
49
[A case of oldest-old patient with chronic renal failure successfully treated with peritoneal dialysis]. 61
32893214 2020
50
Cardiovascular System Affection and Its Relation to First-Year Mortality in Patients Initiating Maintenance Hemodialysis. 61
32753937 2020

Variations for Nephrosclerosis

Expression for Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for Nephrosclerosis

Pathways related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 VEGFA TNF TGFB1 INS CCN2 CCL2
2
Show member pathways
12.81 TGFB1 INS HIF1A CCN2 CCL2 BMP7
3
Show member pathways
12.76 VEGFA TNF TGFB1 INS AGTR1
4 12.2 VEGFA TNF TGFB1 HIF1A
5
Show member pathways
12.16 TNF MTHFR MPO INS CCL2
6
Show member pathways
12.15 TNF TGFB1 ADRB1 ACE
7 11.95 TNF TGFB1 INS HIF1A
8 11.75 VEGFA TNF TGFB1 CCL2
9 11.71 TGFB1 HIF1A F3 CCL2
10 11.71 VEGFA TNF TGFB1 HIF1A CCL2
11 11.61 AGTR1 ADRB1 ACE
12 11.58 VEGFA TGFB1 BMP7
13 11.57 TGFB1 SYNPO NPHS2 NPHS1
14
Show member pathways
11.46 TGFB1 NR3C2 AGTR1 ACE2 ACE
15 11.45 VEGFA TGFB1 HIF1A
16 11.43 TNF TGFB1 CCL2
17 11.4 VEGFA TGFB1 INS
18 11.39 TNF MPO CCN2
19 11.18 CCL2 ACE2 ACE
20 11.15 TNF TGFB1 CCN2 CCL2 BMP7
21 11.1 VEGFA TNF TGFB1 F3 CCL2 AGTR1
22 10.89 TNF TGFB1 CCN2 CCL2 BMP7 ADRB1
23 10.75 TNF MPO CCL2
24 10.56 VEGFA HIF1A

GO Terms for Nephrosclerosis

Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNF TGFB1 MPO INS F3
2 cell surface GO:0009986 9.63 VEGFA TNF TGFB1 F3 ADAMTS13 ACE2
3 extracellular space GO:0005615 9.4 VEGFA TNF TGFB1 MPO INS F3
4 slit diaphragm GO:0036057 9.26 NPHS2 NPHS1

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 VEGFA NR3C2 INS HIF1A CCN2 CCL2
2 positive regulation of cell migration GO:0030335 9.99 VEGFA TGFB1 INS F3
3 angiogenesis GO:0001525 9.98 VEGFA HIF1A CCN2 CCL2
4 positive regulation of protein phosphorylation GO:0001934 9.96 VEGFA TNF TGFB1 CCN2
5 response to hypoxia GO:0001666 9.93 VEGFA TGFB1 MTHFR HIF1A
6 kidney development GO:0001822 9.86 VEGFA BMP7 AGTR1 ACE
7 positive regulation of endothelial cell proliferation GO:0001938 9.85 VEGFA HIF1A F3
8 cellular response to organic cyclic compound GO:0071407 9.84 TNF TGFB1 CCL2
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 VEGFA TNF TGFB1 CCN2 CCL2
10 positive regulation of MAP kinase activity GO:0043406 9.82 VEGFA TNF TGFB1
11 positive regulation of protein complex assembly GO:0031334 9.82 VEGFA TNF TGFB1
12 regulation of cell proliferation GO:0042127 9.8 TNF TGFB1 HIF1A AGTR1 ACE2
13 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 VEGFA TGFB1 HIF1A
14 positive regulation of cell differentiation GO:0045597 9.77 INS CCN2 BMP7
15 epithelial to mesenchymal transition GO:0001837 9.76 TGFB1 HIF1A BMP7
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.75 TNF TGFB1 HIF1A
17 protein kinase B signaling GO:0043491 9.74 TNF TGFB1 CCL2
18 negative regulation of gene expression GO:0010629 9.73 VEGFA TNF TGFB1 HIF1A CCN2 ACE
19 positive regulation of protein kinase B signaling GO:0051897 9.72 VEGFA TNF TGFB1 INS F3
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 TNF TGFB1 CCL2
21 positive regulation of positive chemotaxis GO:0050927 9.69 VEGFA F3
22 surfactant homeostasis GO:0043129 9.69 VEGFA TGFB1
23 angiotensin maturation GO:0002003 9.69 ACE2 ACE
24 regulation of blood vessel diameter GO:0097746 9.69 AGTR1 ACE2 ACE
25 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TNF TGFB1
26 positive regulation of vascular permeability GO:0043117 9.68 VEGFA TGFB1
27 positive regulation of cardiac muscle contraction GO:0060452 9.67 CCN2 ACE2
28 positive regulation of nitric-oxide synthase activity GO:0051000 9.67 TNF INS HIF1A
29 regulation of transmembrane transporter activity GO:0022898 9.66 INS ACE2
30 salivary gland morphogenesis GO:0007435 9.66 TGFB1 BMP7
31 vascular endothelial growth factor production GO:0010573 9.65 TNF HIF1A
32 regulation of vasoconstriction GO:0019229 9.65 AGTR1 ACE2 ACE
33 positive regulation of mononuclear cell migration GO:0071677 9.64 TNF TGFB1
34 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.63 VEGFA HIF1A
35 camera-type eye morphogenesis GO:0048593 9.63 VEGFA HIF1A BMP7
36 cytokine-mediated signaling pathway GO:0019221 9.63 VEGFA TNF TGFB1 HIF1A F3 CCL2
37 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.61 VEGFA ACE
38 connective tissue development GO:0061448 9.61 TGFB1 CCN2
39 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.6 TGFB1 HIF1A
40 neural fold elevation formation GO:0021502 9.55 HIF1A BMP7
41 positive regulation of cellular protein metabolic process GO:0032270 9.54 TGFB1 INS AGTR1
42 mononuclear cell proliferation GO:0032943 9.52 TGFB1 ACE
43 positive regulation of gene expression GO:0010628 9.23 VEGFA TNF TGFB1 INS HIF1A F3
44 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 AGTR1 ACE2 ACE

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.62 VEGFA MPO CCN2 BMP7
2 growth factor activity GO:0008083 9.56 VEGFA TGFB1 CCN2 BMP7
3 peptidyl-dipeptidase activity GO:0008241 9.16 ACE2 ACE
4 cytokine activity GO:0005125 9.02 VEGFA TNF TGFB1 CCL2 BMP7
5 bradykinin receptor binding GO:0031711 8.96 AGTR1 ACE

Sources for Nephrosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....