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MCID: NPH010
MIFTS: 45

Nephrosclerosis

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nephrosclerosis

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MalaCards integrated aliases for Nephrosclerosis:

Name: Nephrosclerosis 12 76 53 29 55 44 15 73
Renal Sclerosis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11664
ICD10 33 I12 N26.9
ICD9CM 35 587
MeSH 44 D009400
SNOMED-CT 68 32916005
UMLS 73 C0027719
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Summaries for Nephrosclerosis

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MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to malignant hypertension and glomerulonephritis. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy (DCM). The drugs Sirolimus and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high... more...

Sources

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 malignant hypertension 30.3 ACE ADAMTS13 AGTR1
2 glomerulonephritis 30.0 CCL2 NPHS1 NPHS2 TGFB1
3 hypertensive heart disease 30.0 ACE AGTR1 NR3C2
4 renal hypertension 30.0 ACE AGTR1
5 renovascular hypertension 29.9 ACE AGTR1
6 heart disease 29.9 ACE ADRB1 AGTR1 MTHFR
7 hypertension, essential 29.8 ACE ADRB1 AGTR1 NR3C2
8 microvascular complications of diabetes 3 29.6 ACE AGTR1 NPHS1
9 coronary heart disease 1 29.5 ACE ADRB1 AGTR1 MTHFR
10 kidney disease 29.4 ACE AGTR1 CCL2 NPHS1 NPHS2 NR3C2
11 end stage renal failure 29.3 ACE AGTR1 NPHS1 NPHS2 TGFB1
12 chronic kidney failure 29.2 ACE AGTR1 MTHFR NPHS1 NPHS2 TGFB1
13 iga glomerulonephritis 29.1 ACE AGTR1 CCL2 NPHS1 NPHS2 TGFB1
14 renal artery disease 10.2 ACE AGTR1
15 familial vesicoureteral reflux 10.2 ACE TGFB1
16 hypertensive nephropathy 10.2 ACE AGTR1
17 diastolic heart failure 10.2 ACE AGTR1
18 diabetic foot ulcers 10.2 CCL2 TGFB1
19 ascending cholangitis 10.2 CCL2 TGFB1
20 renal tubular dysgenesis 10.2 ACE AGTR1
21 hemolytic-uremic syndrome 10.2
22 peyronie's disease 10.2 CCL2 TGFB1
23 posterior urethral valves 10.2 ACE AGTR1 TGFB1
24 meningococcal infection 10.1 ADRB1 AGTR1
25 fibromuscular dysplasia 10.1 ACE AGTR1 TGFB1
26 otosclerosis 10.1 ACE AGTR1 TGFB1
27 tuberculous meningitis 10.1 CCL2 TGFB1
28 arteritic anterior ischemic optic neuropathy 10.1 ACE MTHFR
29 evans' syndrome 10.1 ADAMTS13 TGFB1
30 idiopathic edema 10.1 ACE NR3C2
31 pyelonephritis 10.1
32 cerebral atherosclerosis 10.1 ACE MTHFR
33 arteries, anomalies of 10.1 ACE AGTR1 CCL2
34 silicosis 10.1 ACE CCL2 TGFB1
35 aortic coarctation 10.1 ACE ADRB1 AGTR1
36 crescentic glomerulonephritis 10.1 CCL2 NPHS2 SYNPO
37 coronary artery anomaly 10.1 ACE ADRB1 AGTR1
38 anuria 10.1 ACE AGTR1 NR3C2
39 acute myocardial infarction 10.1 ACE ADRB1 AGTR1
40 retinal artery occlusion 10.1 ACE MTHFR
41 arteriosclerosis 10.0
42 ischemia 10.0
43 uremia 10.0
44 heart valve disease 10.0 ACE NR3C2 TGFB1
45 atrial fibrillation 10.0 ACE ADRB1 AGTR1
46 retinal vascular occlusion 10.0 CCL2 MTHFR
47 grange syndrome 10.0 CCL2 MTHFR
48 ischemic optic neuropathy 10.0 ACE AGTR1 MTHFR
49 nonarteritic anterior ischemic optic neuropathy 10.0 ACE AGTR1 MTHFR
50 nephrotic syndrome, type 6 10.0 NPHS1 NPHS2

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hydronephrosis
Hypertension, Essential Ischemic Heart Disease
Kidney Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis
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Symptoms & Phenotypes for Nephrosclerosis

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MGI Mouse Phenotypes related to Nephrosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 ACE ADRB1 AGTR1 BMP5 NPHS2 NR3C2
2 growth/size/body region MP:0005378 9.86 ACE ADRB1 AGTR1 BMP5 MTHFR NPHS2
3 homeostasis/metabolism MP:0005376 9.85 ACE ADAMTS13 ADRB1 AGTR1 BMP5 MTHFR
4 mortality/aging MP:0010768 9.65 ACE ADAMTS13 ADRB1 AGTR1 BMP5 MTHFR
5 renal/urinary system MP:0005367 9.23 ACE AGTR1 BMP5 NPHS1 NPHS2 NR3C2
Sources

Drugs & Therapeutics for Nephrosclerosis

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Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
2
Mycophenolic acid Approved Phase 4 24280-93-1 446541
3
Everolimus Approved Phase 4 159351-69-6 6442177
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
7
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
8 Immunosuppressive Agents Phase 4
9 Antitubercular Agents Phase 4
10 Antirheumatic Agents Phase 4
11 Immunologic Factors Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Antibiotics, Antitubercular Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Antifungal Agents Phase 4
18 Anti-Bacterial Agents Phase 4
19 Cyclosporins Phase 4
20 Dermatologic Agents Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
22 glucocorticoids Phase 4
23 Calcineurin Inhibitors Phase 4
24 Anti-Infective Agents Phase 4
25 Antihypertensive Agents Phase 4,Phase 2,Phase 3
26 Angiotensin Receptor Antagonists Phase 4
27 Angiotensin II Type 1 Receptor Blockers Phase 4
28 Angiotensinogen Phase 4
29
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5280427 5282411
30 Beraprost Investigational Phase 2, Phase 3 88430-50-6
31 Tezosentan Investigational Phase 2, Phase 3 180384-57-0
32 Vasodilator Agents Phase 2, Phase 3
33 Platelet Aggregation Inhibitors Phase 2, Phase 3
34
Fluvastatin Approved 93957-54-1 1548972
35
Simvastatin Approved 79902-63-9 54454
36
Lovastatin Approved, Investigational 75330-75-5 53232
37
Pravastatin Approved 81093-37-0 54687
38 L 647318
39 Atorvastatin Calcium 134523-03-8
40 Calcium, Dietary
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors
42 Anticholesteremic Agents
43 Dihydromevinolin
44 Lipid Regulating Agents
45 Rosuvastatin Calcium 147098-20-2
46 Antimetabolites
47 Hypolipidemic Agents
48 Hematinics
49 Epoetin alfa 113427-24-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus Completed NCT00371826 Phase 4 Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
2 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
3 TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 Renal NCE-MRI in Healthy Volunteers Completed NCT02618460 Not Applicable
6 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
7 An Observational Study of Methoxy Polyethylene Glycol-epoetin Beta in Participants With a Kidney Transplant Completed NCT02538107 Methoxy-polyethyleneglycol epoetin beta

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

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Genetic Tests for Nephrosclerosis

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Genetic tests related to Nephrosclerosis:

# Genetic test Affiliating Genes
1 Nephrosclerosis 29
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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

41
Kidney, Pituitary, Heart, Bone, Pancreas, Smooth Muscle, Cortex
Sources

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50) (show all 289)
# Title Authors Year
1
Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan. ( 29882111 )
2018
2
Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study. ( 29788462 )
2018
3
Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses. ( 29328390 )
2018
4
Volume Ratio of Glomerular Tufts to Bowman Capsules and Renal Outcomes in Nephrosclerosis. ( 30358804 )
2018
5
Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. ( 29127556 )
2017
6
Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension. ( 27190365 )
2016
7
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( 27784849 )
2016
8
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
9
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. ( 27066888 )
2016
10
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. ( 26857648 )
2016
11
Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis. ( 26809068 )
2016
12
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis. ( 25631380 )
2015
13
Malignant nephrosclerosis in a patient with familial Mediterranean fever. ( 26466703 )
2015
14
Nephrosclerosis: A Term in Quest of a Disease. ( 25871843 )
2015
15
Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center. ( 25838316 )
2015
16
The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. ( 26557147 )
2015
17
Nephrosclerosis: update on a centenarian. ( 25488894 )
2014
18
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. ( 24958497 )
2014
19
A multinational phase IIb/III trial of beraprost sodium, an orally active prostacyclin analogue, in patients with primary glomerular disease or nephrosclerosis (CASSIOPEIR trial), rationale and study design. ( 25233856 )
2014
20
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. ( 24305517 )
2013
21
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. ( 23151750 )
2013
22
Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat. ( 24066937 )
2013
23
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. ( 24136919 )
2013
24
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. ( 23857095 )
2013
25
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. ( 24327566 )
2013
26
Hypertensive nephrosclerosis: not enough of a good thing? ( 23283991 )
2013
27
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. ( 24102027 )
2013
28
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. ( 23135868 )
2013
29
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. ( 23832327 )
2013
30
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. ( 23902971 )
2013
31
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. ( 22236281 )
2012
32
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. ( 22821095 )
2012
33
Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis. ( 22319217 )
2012
34
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? ( 21832860 )
2011
35
Nephrosclerosis and carotid atherosclerosis: lessons from kidney donor histology. ( 21777346 )
2011
36
Hypertensive nephrosclerosis in Kenya. ( 22179094 )
2011
37
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. ( 21319131 )
2011
38
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. ( 21346373 )
2011
39
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. ( 20689330 )
2011
40
ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. ( 20923926 )
2011
41
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. ( 20801567 )
2010
42
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. ( 20019191 )
2010
43
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. ( 19910931 )
2010
44
Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. ( 20651163 )
2010
45
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. ( 21080950 )
2010
46
The association between age and nephrosclerosis on renal biopsy among healthy adults. ( 20439574 )
2010
47
Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. ( 20484896 )
2010
48
Renal dysplasia and nephrosclerosis in calves. ( 19933543 )
2009
49
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. ( 19745105 )
2009
50
Podocyte loss in human hypertensive nephrosclerosis. ( 19131934 )
2009
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Variations for Nephrosclerosis

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Expression for Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.
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Pathways for Nephrosclerosis

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Pathways related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
p70S6K Signaling 64
Show member pathways
 12.6 ACE AGTR1 BMP5 CCL2 TGFB1
2
Dilated cardiomyopathy (DCM) 37
Show member pathways
 11.78 ACE ADRB1 TGFB1
3
AGE-RAGE signaling pathway in diabetic complications 37
11.43 AGTR1 CCL2 TGFB1
4
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 61
Show member pathways
 11.16 ACE AGTR1 NR3C2 TGFB1
5
Renin secretion 37
11.14 ACE ADRB1 AGTR1
6
A-beta Pathways: Uptake and Degradation 65
10.96 ACE CCL2
7
Nephrin/Neph1 signaling in the kidney podocyte 1
10.82 NPHS1 NPHS2
8
Primary Focal Segmental Glomerulosclerosis FSGS 1
10.79 NPHS1 NPHS2 SYNPO TGFB1
9
G-protein signaling_Rap2B regulation pathway 22
10.64 ADRB1 BMP5 CCL2 TGFB1
Sources

GO Terms for Nephrosclerosis

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Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase B signaling GO:0043491 9.46 CCL2 TGFB1
2 excretion GO:0007588 9.43 NPHS1 NPHS2
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.4 CCL2 TGFB1
4 regulation of vasoconstriction GO:0019229 9.37 ACE AGTR1
5 positive regulation of cellular protein metabolic process GO:0032270 9.32 AGTR1 TGFB1
6 peptide catabolic process GO:0043171 9.26 ACE ADAMTS13
7 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
8 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
9 mononuclear cell proliferation GO:0032943 8.62 ACE TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 BMP5 CCL2 TGFB1
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1
Sources

Sources for Nephrosclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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