MCID: NPH010
MIFTS: 47

Nephrosclerosis

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Nephrosclerosis

MalaCards integrated aliases for Nephrosclerosis:

Name: Nephrosclerosis 12 76 53 29 55 44 15 73
Renal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11664
ICD10 33 I12 N26.9
ICD9CM 35 587
MeSH 44 D009400
UMLS 73 C0027719

Summaries for Nephrosclerosis

MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to renal hypertension and glomerulonephritis. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy (DCM). The drugs Everolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 76 Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high... more...

Related Diseases for Nephrosclerosis

Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 renal hypertension 30.4 ACE AGTR1
2 glomerulonephritis 30.3 CCL2 NPHS2 TGFB1
3 malignant hypertension 30.2 ACE ADAMTS13 AGTR1
4 renovascular hypertension 30.1 ACE AGTR1
5 hypertensive heart disease 30.0 ACE AGTR1 NR3C2
6 chronic kidney failure 29.8 ACE AGTR1 NPHS2 TGFB1
7 end stage renal failure 29.6 ACE AGTR1 NPHS2 TGFB1
8 hypertension, essential 29.1 ACE ADRB1 AGTR1 NR3C2
9 microvascular complications of diabetes 3 29.1 ACE AGTR1 CTGF TGFB1
10 iga glomerulonephritis 28.9 ACE AGTR1 CCL2 NPHS2 TGFB1
11 kidney disease 28.6 ACE AGTR1 CCL2 NPHS2 NR3C2 TGFB1
12 heart disease 27.8 ACE ADRB1 AGTR1 MTHFR NR3C2
13 familial vesicoureteral reflux 10.7 ACE TGFB1
14 renal artery disease 10.7 ACE AGTR1
15 hypertensive nephropathy 10.7 ACE AGTR1
16 renal tubular dysgenesis 10.5 ACE AGTR1
17 posterior urethral valves 10.5 ACE AGTR1 TGFB1
18 meningococcal infection 10.5 ADRB1 AGTR1
19 fibromuscular dysplasia 10.5 ACE AGTR1 TGFB1
20 peyronie's disease 10.5 CCL2 TGFB1
21 tuberculous meningitis 10.4 CCL2 TGFB1
22 otosclerosis 10.4 ACE AGTR1 TGFB1
23 evans' syndrome 10.4 ADAMTS13 TGFB1
24 idiopathic edema 10.4 ACE NR3C2
25 membranous nephropathy 10.3 ACE NPHS2 TGFB1
26 pauci-immune glomerulonephritis 10.3 CTGF SYNPO
27 aortic coarctation 10.3 ACE ADRB1 AGTR1
28 silicosis 10.3 ACE CCL2 TGFB1
29 cholecystolithiasis 10.3 CTGF TGFB1
30 stiff skin syndrome 10.3 CTGF TGFB1
31 anuria 10.2 ACE AGTR1 NR3C2
32 acute myocardial infarction 10.2 ACE ADRB1 AGTR1
33 lipoid nephrosis 10.2 CCL2 NPHS2 SYNPO
34 crescentic glomerulonephritis 10.2 CCL2 NPHS2 SYNPO
35 diffuse mesangial sclerosis 10.2 NPHS2 TGFB1
36 atrial fibrillation 10.1 ACE ADRB1 AGTR1
37 gingival disease 10.1 CTGF TGFB1
38 cerebral atherosclerosis 10.1 ACE MTHFR
39 diastolic heart failure 10.1 ACE AGTR1 CTGF
40 localized scleroderma 10.1 CTGF TGFB1
41 aging 10.1
42 systemic scleroderma 10.0 ACE CTGF TGFB1
43 focal segmental glomerulosclerosis 10.0 ACE NPHS2 SYNPO TGFB1
44 systolic heart failure 10.0 ACE ADRB1 NR3C2
45 hemolytic-uremic syndrome 10.0
46 kidney hypertrophy 10.0 CTGF NPHS2 TGFB1
47 proliferative glomerulonephritis 10.0 CCL2 CTGF
48 arteritic anterior ischemic optic neuropathy 9.9 ACE MTHFR
49 pyelonephritis 9.9
50 arteriosclerosis 9.9

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hydronephrosis
Hypertension, Essential Ischemic Heart Disease
Kidney Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis

Symptoms & Phenotypes for Nephrosclerosis

MGI Mouse Phenotypes related to Nephrosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 BMP5 CTGF NPHS2 ACE NR3C2 ADRB1
2 growth/size/body region MP:0005378 9.91 BMP5 CTGF MTHFR NPHS2 ACE NR3C2
3 homeostasis/metabolism MP:0005376 9.85 BMP5 CTGF MTHFR NPHS2 ACE ADAMTS13
4 mortality/aging MP:0010768 9.65 BMP5 CTGF MTHFR NPHS2 ACE ADAMTS13
5 renal/urinary system MP:0005367 9.17 NPHS2 ACE NR3C2 SYNPO TGFB1 AGTR1

Drugs & Therapeutics for Nephrosclerosis

Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4 159351-69-6 6442177
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
7
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
8
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
9 Anti-Bacterial Agents Phase 4
10 Antibiotics, Antitubercular Phase 4
11 Antifungal Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Antirheumatic Agents Phase 4
16 Antitubercular Agents Phase 4
17 Calcineurin Inhibitors Phase 4
18 Cyclosporins Phase 4
19 Dermatologic Agents Phase 4
20 glucocorticoids Phase 4
21 Hormone Antagonists Phase 4
22 Hormones Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Immunosuppressive Agents Phase 4
25 Antihypertensive Agents Phase 4,Phase 2,Phase 3
26 Angiotensin II Type 1 Receptor Blockers Phase 4
27 Angiotensin Receptor Antagonists Phase 4
28 Angiotensinogen Phase 4
29
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5280427 5282411
30 Beraprost Investigational Phase 2, Phase 3 88430-50-6
31 Tezosentan Investigational Phase 2, Phase 3 180384-57-0
32 Platelet Aggregation Inhibitors Phase 2, Phase 3
33 Vasodilator Agents Phase 2, Phase 3
34
Fluvastatin Approved 93957-54-1 1548972
35
Lovastatin Approved, Investigational 75330-75-5 53232
36
Pravastatin Approved 81093-37-0 54687
37
Simvastatin Approved 79902-63-9 54454
38 Anticholesteremic Agents
39 Antimetabolites
40 Atorvastatin Calcium 134523-03-8
41 Calcium, Dietary
42 Dihydromevinolin
43 Hydroxymethylglutaryl-CoA Reductase Inhibitors
44 Hypolipidemic Agents
45 L 647318
46 Lipid Regulating Agents
47 Rosuvastatin Calcium 147098-20-2
48 Epoetin alfa 113427-24-0
49 Hematinics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus Completed NCT00371826 Phase 4 Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
2 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
3 TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 Renal NCE-MRI in Healthy Volunteers Completed NCT02618460 Not Applicable
6 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
7 An Observational Study of Methoxy Polyethylene Glycol-epoetin Beta in Participants With a Kidney Transplant Completed NCT02538107 Methoxy-polyethyleneglycol epoetin beta

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

Genetic tests related to Nephrosclerosis:

# Genetic test Affiliating Genes
1 Nephrosclerosis 29

Anatomical Context for Nephrosclerosis

MalaCards organs/tissues related to Nephrosclerosis:

41
Kidney, Pituitary, Heart, Pancreas, Bone, Smooth Muscle, Endothelial

Publications for Nephrosclerosis

Articles related to Nephrosclerosis:

(show top 50) (show all 275)
# Title Authors Year
1
Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan. ( 29882111 )
2018
2
Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study. ( 29788462 )
2018
3
Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses. ( 29328390 )
2018
4
Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. ( 29127556 )
2017
5
Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension. ( 27190365 )
2016
6
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( 27784849 )
2016
7
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
8
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. ( 27066888 )
2016
9
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. ( 26857648 )
2016
10
Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis. ( 26809068 )
2016
11
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis. ( 25631380 )
2015
12
Malignant nephrosclerosis in a patient with familial Mediterranean fever. ( 26466703 )
2015
13
Nephrosclerosis: A Term in Quest of a Disease. ( 25871843 )
2015
14
Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center. ( 25838316 )
2015
15
The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. ( 26557147 )
2015
16
Nephrosclerosis: update on a centenarian. ( 25488894 )
2014
17
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. ( 24958497 )
2014
18
A multinational phase IIb/III trial of beraprost sodium, an orally active prostacyclin analogue, in patients with primary glomerular disease or nephrosclerosis (CASSIOPEIR trial), rationale and study design. ( 25233856 )
2014
19
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. ( 24305517 )
2013
20
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. ( 23151750 )
2013
21
Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat. ( 24066937 )
2013
22
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. ( 24136919 )
2013
23
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. ( 23857095 )
2013
24
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. ( 24327566 )
2013
25
Hypertensive nephrosclerosis: not enough of a good thing? ( 23283991 )
2013
26
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. ( 24102027 )
2013
27
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. ( 23135868 )
2013
28
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. ( 23832327 )
2013
29
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. ( 23902971 )
2013
30
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. ( 22236281 )
2012
31
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. ( 22821095 )
2012
32
Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis. ( 22319217 )
2012
33
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? ( 21832860 )
2011
34
Nephrosclerosis and carotid atherosclerosis: lessons from kidney donor histology. ( 21777346 )
2011
35
Hypertensive nephrosclerosis in Kenya. ( 22179094 )
2011
36
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. ( 21319131 )
2011
37
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. ( 21346373 )
2011
38
ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. ( 20923926 )
2011
39
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. ( 20689330 )
2011
40
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. ( 20801567 )
2010
41
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. ( 20019191 )
2010
42
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. ( 19910931 )
2010
43
Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. ( 20651163 )
2010
44
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. ( 21080950 )
2010
45
The association between age and nephrosclerosis on renal biopsy among healthy adults. ( 20439574 )
2010
46
Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. ( 20484896 )
2010
47
Renal dysplasia and nephrosclerosis in calves. ( 19933543 )
2009
48
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. ( 19745105 )
2009
49
Podocyte loss in human hypertensive nephrosclerosis. ( 19131934 )
2009
50
[Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]. ( 19799194 )
2009

Variations for Nephrosclerosis

Expression for Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for Nephrosclerosis

GO Terms for Nephrosclerosis

Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ADAMTS13 BMP5 CCL2 CTGF TGFB1

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.67 BMP5 CCL2 CTGF TGFB1
2 response to amino acid GO:0043200 9.48 CTGF MTHFR
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 CCL2 TGFB1
4 positive regulation of collagen biosynthetic process GO:0032967 9.43 CTGF TGFB1
5 regulation of vasoconstriction GO:0019229 9.4 ACE AGTR1
6 peptide catabolic process GO:0043171 9.32 ACE ADAMTS13
7 positive regulation of cellular protein metabolic process GO:0032270 9.26 AGTR1 TGFB1
8 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
10 mononuclear cell proliferation GO:0032943 8.62 ACE TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 BMP5 CCL2 TGFB1
2 growth factor activity GO:0008083 9.33 BMP5 CTGF TGFB1
3 BMP receptor binding GO:0070700 8.96 BMP5 TGFB1
4 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nephrosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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