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MCID: NPH010
MIFTS: 46

Nephrosclerosis

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Nephrosclerosis

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MalaCards integrated aliases for Nephrosclerosis:

Name: Nephrosclerosis 12 77 54 30 56 45 15 17 74
Renal Sclerosis 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:11664
ICD9CM 36 587
MeSH 45 D009400
SNOMED-CT 69 32916005
ICD10 34 I12 N26.9
UMLS 74 C0027719
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Summaries for Nephrosclerosis

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MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to renal hypertension and hypertensive heart disease. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy (DCM). The drugs Mycophenolic acid and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 77 Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high... more...

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Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 renal hypertension 30.2 ACE AGTR1
2 hypertensive heart disease 30.1 ACE AGTR1 NR3C2
3 renovascular hypertension 30.1 ACE AGTR1
4 glomerulonephritis 29.9 CCL2 NPHS1 NPHS2 TGFB1
5 heart disease 29.7 ACE ADRB1 AGTR1 MTHFR
6 microvascular complications of diabetes 3 29.6 ACE AGTR1 NPHS1
7 coronary heart disease 1 29.6 ACE ADRB1 MTHFR
8 hypertension, essential 29.6 ACE ADRB1 AGTR1 NR3C2
9 end stage renal failure 29.1 ACE AGTR1 NPHS1 NPHS2 TGFB1
10 kidney disease 28.9 ACE AGTR1 CCL2 NPHS1 NPHS2 NR3C2
11 chronic kidney failure 28.9 ACE AGTR1 MTHFR NPHS1 NPHS2 TGFB1
12 iga glomerulonephritis 28.8 ACE AGTR1 CCL2 NPHS1 NPHS2 TGFB1
13 renal artery disease 10.4 ACE AGTR1
14 familial vesicoureteral reflux 10.4 ACE TGFB1
15 hypertensive nephropathy 10.3 ACE AGTR1
16 diastolic heart failure 10.3 ACE AGTR1
17 diabetic foot ulcers 10.3 CCL2 TGFB1
18 ascending cholangitis 10.3 CCL2 TGFB1
19 arteritic anterior ischemic optic neuropathy 10.3 ACE MTHFR
20 renal tubular dysgenesis 10.2 ACE AGTR1
21 peyronie's disease 10.2 CCL2 TGFB1
22 nonspecific interstitial pneumonia 10.2 CCL2 TGFB1
23 posterior urethral valves 10.2 ACE AGTR1 TGFB1
24 evans' syndrome 10.2 ADAMTS13 TGFB1
25 fibromuscular dysplasia 10.2 ACE AGTR1 TGFB1
26 cerebral atherosclerosis 10.2 ACE MTHFR
27 tuberculous meningitis 10.2 CCL2 TGFB1
28 hemolytic-uremic syndrome 10.2
29 idiopathic edema 10.2 ACE NR3C2
30 arteries, anomalies of 10.2 ACE AGTR1 CCL2
31 silicosis 10.2 ACE CCL2 TGFB1
32 retinal artery occlusion 10.1 ACE MTHFR
33 pyelonephritis 10.1
34 meningococcal infection 10.1 ADRB1 AGTR1
35 retinal vascular occlusion 10.1 CCL2 MTHFR
36 crescentic glomerulonephritis 10.1 CCL2 NPHS2 SYNPO
37 catastrophic antiphospholipid syndrome 10.1 ADAMTS13 MTHFR
38 grange syndrome 10.1 CCL2 MTHFR
39 anuria 10.1 ACE AGTR1 NR3C2
40 ischemic heart disease 10.1 ACE AGTR1 MTHFR
41 ischemic optic neuropathy 10.1 ACE AGTR1 MTHFR
42 nonarteritic anterior ischemic optic neuropathy 10.1 ACE AGTR1 MTHFR
43 arteriosclerosis 10.1
44 ischemia 10.1
45 uremia 10.1
46 heart valve disease 10.1 ACE NR3C2 TGFB1
47 acute mountain sickness 10.1 ACE AGTR1
48 cerebrovascular disease 10.1 ACE AGTR1 MTHFR
49 aortic coarctation 10.0 ACE ADRB1 AGTR1
50 retinal vascular disease 10.0 ACE CCL2 MTHFR

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hydronephrosis
Hypertension, Essential Ischemic Heart Disease
Kidney Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis
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Symptoms & Phenotypes for Nephrosclerosis

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MGI Mouse Phenotypes related to Nephrosclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 ACE ADRB1 AGTR1 BMP5 NPHS2 NR3C2
2 growth/size/body region MP:0005378 9.86 ACE ADRB1 AGTR1 BMP5 MTHFR NPHS2
3 homeostasis/metabolism MP:0005376 9.85 ACE ADAMTS13 ADRB1 AGTR1 BMP5 MTHFR
4 mortality/aging MP:0010768 9.65 ACE ADAMTS13 ADRB1 AGTR1 BMP5 MTHFR
5 renal/urinary system MP:0005367 9.23 ACE AGTR1 BMP5 NPHS1 NPHS2 NR3C2
Sources

Drugs & Therapeutics for Nephrosclerosis

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Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4 24280-93-1 446541
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
5
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
6
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
7
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198 65143
8 Anti-Bacterial Agents Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Hormones Phase 4
11 Anti-Infective Agents Phase 4
12 Immunosuppressive Agents Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Hormone Antagonists Phase 4
15 Immunologic Factors Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Antitubercular Agents Phase 4
18 Cyclosporins Phase 4
19 Antifungal Agents Phase 4
20 Dermatologic Agents Phase 4
21 Antirheumatic Agents Phase 4
22 Calcineurin Inhibitors Phase 4
23 glucocorticoids Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 Antihypertensive Agents Phase 4,Phase 2,Phase 3
26 Giapreza Phase 4
27 Angiotensinogen Phase 4
28 Angiotensin II Type 1 Receptor Blockers Phase 4
29 Angiotensin Receptor Antagonists Phase 4
30
Epoprostenol Approved Phase 2, Phase 3 35121-78-9, 61849-14-7 5280427 5282411
31 Tezosentan Investigational Phase 2, Phase 3 180384-57-0
32 Beraprost Investigational Phase 2, Phase 3 88430-50-6
33 Vasodilator Agents Phase 2, Phase 3
34 Platelet Aggregation Inhibitors Phase 2, Phase 3
35
Pravastatin Approved 81093-37-0 54687
36
Lovastatin Approved, Investigational 75330-75-5 53232
37
Atorvastatin Approved 134523-00-5 60823
38
Simvastatin Approved 79902-63-9 54454
39
Calcium Approved, Nutraceutical 7440-70-2 271
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors
41 Antimetabolites
42 Hypolipidemic Agents
43 Rosuvastatin Calcium 147098-20-2
44 Dihydromevinolin
45 L 647318
46 Calcium, Dietary
47 Lipid Regulating Agents
48 Anticholesteremic Agents
49 Hematinics
50 Epoetin alfa 113427-24-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus Completed NCT00371826 Phase 4 Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
2 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
3 TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 Renal NCE-MRI in Healthy Volunteers Completed NCT02618460 Not Applicable
6 High Potency Statins and Acute Kidney Injury Completed NCT02518516 Rosuvastatin (≥10 mg);Atorvastatin (≥20 mg);Simvastatin (≥40 mg);Fluvastatin;Pravastatin;Lovastatin;Atorvastatin (<20mg);Simvastatin (<40 mg)
7 An Observational Study of Methoxy Polyethylene Glycol-epoetin Beta in Participants With a Kidney Transplant Completed NCT02538107 Methoxy-polyethyleneglycol epoetin beta

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

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Genetic Tests for Nephrosclerosis

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Genetic tests related to Nephrosclerosis:

# Genetic test Affiliating Genes
1 Nephrosclerosis 30
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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

42
Kidney, Pituitary, Heart, Bone, Pancreas, Smooth Muscle, Spleen
Sources

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50) (show all 293)
# Title Authors Year
1
Larger nephron size, low nephron number, and nephrosclerosis on biopsy as predictors of kidney function after donating a kidney. ( 30629312 )
2019
2
Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients with Biopsy-Proven Hypertensive Nephrosclerosis. ( 30689693 )
2019
3
Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis. ( 30775629 )
2019
4
Pathogenic role of angiotensin II and the NF-κB system in a model of malignant hypertensive nephrosclerosis. ( 30809002 )
2019
5
Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan. ( 29882111 )
2018
6
Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study. ( 29788462 )
2018
7
Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses. ( 29328390 )
2018
8
Volume Ratio of Glomerular Tufts to Bowman Capsules and Renal Outcomes in Nephrosclerosis. ( 30358804 )
2018
9
Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. ( 29127556 )
2017
10
Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension. ( 27190365 )
2016
11
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( 27784849 )
2016
12
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
13
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. ( 27066888 )
2016
14
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. ( 26857648 )
2016
15
Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis. ( 26809068 )
2016
16
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis. ( 25631380 )
2015
17
Malignant nephrosclerosis in a patient with familial Mediterranean fever. ( 26466703 )
2015
18
Nephrosclerosis: A Term in Quest of a Disease. ( 25871843 )
2015
19
Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center. ( 25838316 )
2015
20
The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. ( 26557147 )
2015
21
Nephrosclerosis: update on a centenarian. ( 25488894 )
2014
22
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. ( 24958497 )
2014
23
A multinational phase IIb/III trial of beraprost sodium, an orally active prostacyclin analogue, in patients with primary glomerular disease or nephrosclerosis (CASSIOPEIR trial), rationale and study design. ( 25233856 )
2014
24
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. ( 24305517 )
2013
25
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. ( 23151750 )
2013
26
Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat. ( 24066937 )
2013
27
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. ( 24136919 )
2013
28
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. ( 23857095 )
2013
29
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. ( 24327566 )
2013
30
Hypertensive nephrosclerosis: not enough of a good thing? ( 23283991 )
2013
31
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. ( 24102027 )
2013
32
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. ( 23135868 )
2013
33
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. ( 23832327 )
2013
34
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. ( 23902971 )
2013
35
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. ( 22236281 )
2012
36
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. ( 22821095 )
2012
37
Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis. ( 22319217 )
2012
38
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? ( 21832860 )
2011
39
Nephrosclerosis and carotid atherosclerosis: lessons from kidney donor histology. ( 21777346 )
2011
40
Hypertensive nephrosclerosis in Kenya. ( 22179094 )
2011
41
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. ( 21319131 )
2011
42
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. ( 21346373 )
2011
43
ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. ( 20923926 )
2011
44
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. ( 20689330 )
2011
45
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. ( 20801567 )
2010
46
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. ( 20019191 )
2010
47
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. ( 19910931 )
2010
48
Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. ( 20651163 )
2010
49
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. ( 21080950 )
2010
50
The association between age and nephrosclerosis on renal biopsy among healthy adults. ( 20439574 )
2010
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Variations for Nephrosclerosis

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Expression for Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.
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Pathways for Nephrosclerosis

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Pathways related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
p70S6K Signaling 65
Show member pathways
 12.6 ACE AGTR1 BMP5 CCL2 TGFB1
2
Dilated cardiomyopathy (DCM) 38
Show member pathways
 11.79 ACE ADRB1 TGFB1
3
AGE-RAGE signaling pathway in diabetic complications 38
11.43 AGTR1 CCL2 TGFB1
4
Renin secretion 38
11.17 ACE ADRB1 AGTR1
5
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics 62
Show member pathways
 11.16 ACE AGTR1 NR3C2 TGFB1
6
A-beta Pathways: Uptake and Degradation 66
10.96 ACE CCL2
7
Nephrin/Neph1 signaling in the kidney podocyte 1
10.82 NPHS1 NPHS2
8
Primary Focal Segmental Glomerulosclerosis FSGS 1
10.79 NPHS1 NPHS2 SYNPO TGFB1
9
G-protein signaling_Rap2B regulation pathway 23
10.64 ADRB1 BMP5 CCL2 TGFB1
Sources

GO Terms for Nephrosclerosis

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Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase B signaling GO:0043491 9.46 CCL2 TGFB1
2 excretion GO:0007588 9.43 NPHS1 NPHS2
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.4 CCL2 TGFB1
4 regulation of vasoconstriction GO:0019229 9.37 ACE AGTR1
5 positive regulation of cellular protein metabolic process GO:0032270 9.32 AGTR1 TGFB1
6 peptide catabolic process GO:0043171 9.26 ACE ADAMTS13
7 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
8 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
9 mononuclear cell proliferation GO:0032943 8.62 ACE TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 BMP5 CCL2 TGFB1
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1
Sources

Sources for Nephrosclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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