MCID: NPH012
MIFTS: 59

Nephrotic Syndrome

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Immune diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Nephrotic Syndrome

MalaCards integrated aliases for Nephrotic Syndrome:

Name: Nephrotic Syndrome 12 77 38 30 56 6 45 15 41 17 74
Finnish Congenital Nephrotic Syndrome 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1184
KEGG 38 H01657
ICD9CM 36 581
MeSH 45 D009404
NCIt 51 C34845
SNOMED-CT 69 52254009
ICD10 34 N04 N04.9

Summaries for Nephrotic Syndrome

Disease Ontology : 12 A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.

MalaCards based summary : Nephrotic Syndrome, also known as finnish congenital nephrotic syndrome, is related to nephrotic syndrome, type 1 and familial nephrotic syndrome, and has symptoms including edema An important gene associated with Nephrotic Syndrome is NPHS2 (NPHS2 Stomatin Family Member, Podocin), and among its related pathways/superpathways are Hexose transport and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Mycophenolic acid and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 77 Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine,... more...

Related Diseases for Nephrotic Syndrome

Diseases in the Nephrotic Syndrome family:

Nephrotic Syndrome, Type 1 Nephrotic Syndrome, Type 4
Nephrotic Syndrome, Type 2 Nephrotic Syndrome, Type 3
Nephrotic Syndrome, Type 6 Nephrotic Syndrome, Type 7
Nephrotic Syndrome, Type 8 Nephrotic Syndrome, Type 9
Nephrotic Syndrome, Type 10 Nephrotic Syndrome, Type 11
Nephrotic Syndrome, Type 12 Nephrotic Syndrome, Type 13
Nephrotic Syndrome, Type 14 Nephrotic Syndrome, Type 15
Nephrotic Syndrome, Type 16 Nephrotic Syndrome, Type 17
Nephrotic Syndrome, Type 18 Nephrotic Syndrome, Type 19
Familial Nephrotic Syndrome

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 709)
# Related Disease Score Top Affiliating Genes
1 nephrotic syndrome, type 1 34.4 NPHS1 NPHS2 WT1
2 familial nephrotic syndrome 34.2 NPHS1 NPHS2 PLCE1 WT1
3 lipoid nephrosis 33.8 ALB NPHS1 NPHS2
4 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 33.7 PLCE1 WT1
5 pierson syndrome 33.6 LAMB2 NPHS2
6 nephrotic syndrome, type 6 33.3 ARHGDIA EMP2 NPHS1 NPHS2 NUP93 PLCE1
7 galloway-mowat syndrome 33.3 NPHS1 NPHS2 NUP107
8 hypoparathyroidism, sensorineural deafness, and renal disease 32.8 LAMB2 NPHS1 NPHS2
9 denys-drash syndrome 32.8 NPHS1 NPHS2 WT1
10 membranous nephropathy 32.6 ALB NPHS1 NPHS2
11 frasier syndrome 32.5 NPHS1 NPHS2 PLCE1 WT1
12 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 32.4 COQ8B NPHS1 NPHS2 NUP107 NUP205 NUP93
13 diffuse mesangial sclerosis 32.0 ARHGDIA LAMB2 NPHS1 NPHS2 PLCE1 WT1
14 focal segmental glomerulosclerosis 32.0 ALB COQ6 LAMB2 NPHS1 NPHS2 NUP107
15 glomerulonephritis 31.2 ALB NPHS1 NPHS2
16 iga glomerulonephritis 30.8 ALB NPHS1 NPHS2
17 chronic kidney failure 30.3 ALB NPHS1 NPHS2 WT1
18 crescentic glomerulonephritis 29.9 NPHS2 PTPRO WT1
19 wilms tumor 1 29.6 NPHS1 NPHS2 PTPRO WT1
20 familial lcat deficiency 29.5 ALB APOA1
21 nephrotic syndrome, type 2 12.6
22 nephrotic syndrome, type 5, with or without ocular abnormalities 12.5
23 nephrotic syndrome, type 3 12.5
24 nephrotic syndrome, type 15 12.5
25 nephrotic syndrome, type 7 12.4
26 congenital nephrotic syndrome finnish type 12.4
27 nephrotic syndrome, type 14 12.4
28 nephrotic syndrome, type 4 12.4
29 nephrotic syndrome, type 9 12.4
30 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 12.4
31 nephrotic syndrome, type 12 12.4
32 nephrotic syndrome, type 8 12.4
33 nephrotic syndrome, type 11 12.4
34 nephrotic syndrome, type 13 12.4
35 nephrotic syndrome, type 10 12.4
36 nephrotic syndrome, type 16 12.4
37 nephrotic syndrome, type 17 12.3
38 nephrotic syndrome, type 18 12.3
39 nephrotic syndrome, type 19 12.3
40 sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 12.1
41 idiopathic steroid-sensitive nephrotic syndrome with focal segmental hyalinosis 12.1
42 nephrotic syndrome, idiopathic, steroid-resistant 12.1
43 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 12.1
44 sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes 12.1
45 idiopathic steroid-sensitive nephrotic syndrome with minimal change 12.1
46 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 12.1
47 sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy 12.1
48 nephrotic syndrome ocular anomalies 12.0
49 leigh syndrome with nephrotic syndrome 12.0
50 coenzyme q10 deficiency, primary, 6 11.9

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to Nephrotic Syndrome

Symptoms & Phenotypes for Nephrotic Syndrome

UMLS symptoms related to Nephrotic Syndrome:


edema

MGI Mouse Phenotypes related to Nephrotic Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 APOA1 ARHGDIA EMP2 ITGA3 MAGI2 NPHS2
2 homeostasis/metabolism MP:0005376 9.77 ALB APOA1 ARHGDIA COQ6 ITGA3 LAMB2
3 renal/urinary system MP:0005367 9.36 ALB ARHGDIA ITGA3 LAMB2 MAGI2 NPHS1

Drugs & Therapeutics for Nephrotic Syndrome

Drugs for Nephrotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 200)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
7
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492 6473866
8
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
9
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
10
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
11
Furosemide Approved, Vet_approved Phase 4,Not Applicable 54-31-9 3440
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
13
Pravastatin Approved Phase 4,Phase 1 81093-37-0 54687
14
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
15
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
16
Calcium Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 7440-70-2 271
17
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
18
Ergocalciferol Approved, Nutraceutical Phase 4,Not Applicable 50-14-6 5280793
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 1406-16-2
20
Vitamin D3 Approved, Nutraceutical Phase 4,Not Applicable 67-97-0 5280795 6221
21
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
22
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
23
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Not Applicable 2920-86-7
24 Tocotrienol Investigational Phase 4 6829-55-6
25 Prednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
26 Vaccines Phase 4
27 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2,Not Applicable
29 Cyclosporins Phase 4,Phase 2
30 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
31 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Antiemetics Phase 4,Phase 3,Phase 2,Not Applicable
40 Protective Agents Phase 4,Phase 3,Not Applicable
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
43 Calcineurin Inhibitors Phase 4,Phase 2,Phase 3
44 Antitubercular Agents Phase 4,Phase 3
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
46 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 beta-endorphin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Adrenocorticotropic Hormone Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 134)
# Name Status NCT ID Phase Drugs
1 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
2 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
3 Long Term Tapering or Standard Steroids for Nephrotic Syndrome Unknown status NCT00308321 Phase 4 long term tapering of prednisolone;standard prednisolone treatment
4 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Unknown status NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
5 Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome Completed NCT01895894 Phase 4 Mycophenolate mofetil
6 Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children Completed NCT01162005 Phase 4 Tacrolimus
7 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
8 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Completed NCT01763580 Phase 4 Tacrolimus;Prednisolone
9 Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study Completed NCT01185197 Phase 4 Myfortic plus low-dose steroid;Prednisolone
10 Pharmacokinetics of Tacrolimus in Children Completed NCT03347357 Phase 4 Tacrolimus
11 Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes Completed NCT01021540 Phase 4 Repository corticotrophin
12 Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema Completed NCT02427880 Phase 4 Acetazolamide and Hydrochlorothiazide Followed by Furosemide;Furosemide and Hydrochlorothiazide Followed by Furosemide
13 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4 Repository Corticotropin Injection;Placebo
14 Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) Completed NCT01028287 Phase 4 ACTH;ACTH
15 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Completed NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
16 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
17 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome Recruiting NCT02382575 Phase 4 Rituximab;Tacrolimus
18 Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease Recruiting NCT00982072 Phase 4 tacrolimus;prednisolone
19 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
20 Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy Recruiting NCT03210688 Phase 4 Prednisolone;Alfacalcidol
21 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4 Mycophenolate Mofetil;Cyclosporins
22 Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome Not yet recruiting NCT02649413 Phase 4 Prednisone
23 Steroid Sensitive Nephrotic Syndrome in Children Not yet recruiting NCT03878914 Phase 4 Corticosteroids
24 ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children Not yet recruiting NCT03408405 Phase 4 Acthar Gel 80 UNT/ML Injectable Solution
25 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
26 Rituximab Trial for Pediatric Nephrotic Syndrome Unknown status NCT01716442 Phase 2, Phase 3 Rituximab;Placebo
27 Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy Unknown status NCT01508468 Phase 3 symptomatic treatment (Converting Enzyme inhibitor, Angiotensin II, Anti-renin, Aldosterone antagonist diuretic, Beta blocker, Calcium inhibitor, statin);experimental (Non Immunosuppressive Symptomatic Treatment (NIST) and Rituximab)
28 Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome Completed NCT02132195 Phase 3 ACTH
29 Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood Completed NCT01268033 Phase 2, Phase 3 Rituximab;Placebo
30 Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children Completed NCT01092962 Phase 3 Cyclophosphamide;Mycophenolate mofetil
31 Efficacy of Pentoxifylline on Primary Nephrotic Syndrome Completed NCT00354731 Phase 3 pentoxifylline;Corticosteroid
32 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome Completed NCT02438982 Phase 3 Tacrolimus;Rituximab
33 A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome Completed NCT02257697 Phase 3 Mizoribine (MZR);Cyclophosphamide (CTX)
34 Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome Completed NCT01197040 Phase 3 Prednisone;acid mycophenolic (Myfortic)
35 The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS) Completed NCT01309477 Phase 3 Tacrolimus Sustained-release Capsules (ADVAGRAF)
36 Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome Completed NCT00362531 Phase 2, Phase 3 tacrolimus combined with prednisone
37 Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS) Completed NCT00615667 Phase 3 tacrolimus (FK506)
38 Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00981838 Phase 3 Rituximab
39 Steroid Treatment for Kidney Disease Completed NCT00065611 Phase 3 Oral dexamethasone
40 Rituximab in Membranous Nephropathy Completed NCT00425217 Phase 2, Phase 3 Rituximab
41 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3 NC-503 (Anti-amyloidotic (AA) Agent)
42 Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome Completed NCT01084980 Phase 2, Phase 3 Tacrolimus
43 Prednisolone Trial in Children Younger Than 4 Years Recruiting NCT03141970 Phase 3 Prednisolone
44 Lymphocyte Markers As Predictors Of Responsiveness To Rituximab Among Patients With Idiopathic Nephrotic Syndrome Recruiting NCT03501459 Phase 3 Rituximab
45 Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Recruiting NCT02818738 Phase 3 Levamisole Hydrochloride
46 Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Recruiting NCT03298698 Phase 3 Rituximab;Prednisone
47 Valproic Acid for Idiopathic Nephrotic Syndrome Recruiting NCT02896270 Phase 2, Phase 3 Valproic Acid
48 Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy Recruiting NCT03018535 Phase 3 Rituximab;Methylprednisolone;Cyclophosphamide
49 Compare Efficacy and Safety of Repeated Courses of Rituximab to That of Maintenance Mycophenolate Mofetil Following Single Course of Rituximab Among Children With Steroid Dependent Nephrotic Syndrome Not yet recruiting NCT03899103 Phase 3 Rituximab;Mycophenolate Mofetil
50 Efficacy and Safety of Immunoglobulin Associated With Rituximab Versus Rituximab Alone in Childhood-Onset Steroid-dependent Nephrotic Syndrome Not yet recruiting NCT03560011 Phase 2, Phase 3 immunoglobulin IV

Search NIH Clinical Center for Nephrotic Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: nephrotic syndrome

Genetic Tests for Nephrotic Syndrome

Genetic tests related to Nephrotic Syndrome:

# Genetic test Affiliating Genes
1 Nephrotic Syndrome 30

Anatomical Context for Nephrotic Syndrome

MalaCards organs/tissues related to Nephrotic Syndrome:

42
Kidney, Bone, Testes, Lung, T Cells, Liver, Endothelial

Publications for Nephrotic Syndrome

Articles related to Nephrotic Syndrome:

(show top 50) (show all 4254)
# Title Authors Year
1
Radiologically Guided Renal Artery Embolization with an Amplatzer Vascular Plug as a Rescue Therapy for Refractory Nephrotic Syndrome in AL-Amyloidosis. ( 30886753 )
2019
2
Prevalence of Asthma and Allergies and Risk of Relapse in Childhood Nephrotic Syndrome: Insight into Nephrotic Syndrome Cohort. ( 30732999 )
2019
3
Clinical Features of Nephrotic Syndrome with Cerebral Hemorrhage. ( 30904921 )
2019
4
Hodgkin's lymphoma, nephrotic syndrome, and echinococcosis cysts: an unusual association and literature review. ( 30784346 )
2019
5
NPHS2 gene sequencing results in children of the Azerbaijani population with different types of nephrotic syndrome caused by chronic glomerulonephritis. ( 30793612 )
2019
6
Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation. ( 30651070 )
2019
7
Dasatinib-induced nephrotic syndrome in a patient with chronic myelogenous leukemia: a case report. ( 30845905 )
2019
8
Significance of Earlier Initiation of Chemotherapy for Lung Cancer Complicated with Primary or Secondary Nephrotic Syndrome following Its Appropriate Differential Diagnosis. ( 30792645 )
2019
9
Nephrotic syndrome: first presentation of lymphoepithelioma-like thymic carcinoma. ( 30592665 )
2019
10
Focal and Segmental Glomerulosclerosis and Membranous Nephropathy overlapping in a patient with Nephrotic Syndrome: a case report. ( 30806447 )
2019
11
Nephrotic syndrome and mitochondrial disorders: Questions. ( 30863910 )
2019
12
Nephrotic syndrome and mitochondrial disorders: answers. ( 30863911 )
2019
13
A longitudinal study on the effects of psychological stress on proteinuria in childhood steroid-sensitive nephrotic syndrome. ( 30739735 )
2019
14
miR-939-5p decreases the enrichment of RNA polymerase II in the promoter region of CD2AP involved in nephrotic syndrome. ( 30756418 )
2019
15
Genetics of Childhood Steroid Sensitive Nephrotic Syndrome: An Update. ( 30761277 )
2019
16
Repository Corticotropin Versus Glucocorticoid for Nephrotic Syndrome: When Will We See the Evidence? ( 30765104 )
2019
17
The quest for optimal control of relapses in children with nephrotic syndrome. ( 30784663 )
2019
18
Efficacy of Mycophenolate Mofetil as a Remission Maintaining Agent in Idiopathic Childhood Nephrotic Syndrome. ( 30814791 )
2019
19
Profile of Acute Kidney Injury in Hospitalized Children with Idiopathic Nephrotic Syndrome. ( 30819990 )
2019
20
Nephrotic syndrome in a dish: recent developments in modeling in vitro. ( 30820702 )
2019
21
Outcomes of Older Patients (≥60 years) with New-Onset Idiopathic Nephrotic Syndrome Receiving Immunosuppressive Regimen: A Multicentre Study of 116 Patients. ( 30832362 )
2019
22
Electron microscopic findings suggestive of focal and segmental glomerulosclerosis in patients with steroid-resistant nephrotic syndrome. ( 30835594 )
2019
23
Neurological complications in childhood nephrotic syndrome: A systematic review. ( 30837193 )
2019
24
Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China. ( 30864060 )
2019
25
Predictors of rituximab-related neutropenia in Japanese children with steroid-dependent nephrotic syndrome. ( 30887110 )
2019
26
Concerning "Acute kidney injury complicating nephrotic syndrome of minimal change disease". ( 30904072 )
2019
27
Treatment of nephrotic syndrome: going beyond immunosuppressive therapy. ( 30904930 )
2019
28
Nephrotic Syndrome and a Maculopapular Rash. ( 30905362 )
2019
29
Glycated albumin level is significantly decreased in patients suffering nephrotic syndrome. ( 30905459 )
2019
30
Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome. ( 30910934 )
2019
31
Response to "Predictors of rituximab-related neutropenia in Japanese children with steroid-dependent nephrotic syndrome". ( 30915547 )
2019
32
Influenza vaccination among children with idiopathic nephrotic syndrome: an investigation of practices. ( 30803442 )
2019
33
B cell phenotype in pediatric idiopathic nephrotic syndrome. ( 30267238 )
2019
34
Correction to: Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings : A Midwest Pediatric Nephrology Consortium (MWPNC) study. ( 30443740 )
2019
35
Nephrotic Syndrome. ( 30454752 )
2019
36
Increased urinary exosomal microRNAs in children with idiopathic nephrotic syndrome. ( 30467011 )
2019
37
Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome. ( 30514826 )
2019
38
Idiopathic nephrotic syndrome and rituximab: may we predict circulating B lymphocytes recovery? ( 30542932 )
2019
39
Are microRNA potential biomarkers in children with idiopathic nephrotic syndrome? ( 30584009 )
2019
40
Successful re-administration of Pazopanib in a patient with metastatic renal cell carcinoma and a history of Pazopanib-induced nephrotic syndrome: a case report. ( 30606155 )
2019
41
Levamisole for children with nephrotic syndrome: new evidence for the use of an "old" drug. ( 30606425 )
2019
42
Evaluation of the safety, effectiveness, and health-related QOL impact of early rehabilitation in patients with nephrotic syndrome. ( 30607657 )
2019
43
Two different clinical aspects of Japanese children with asymptomatic nephrotic syndrome at onset. ( 30612229 )
2019
44
MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome. ( 30659270 )
2019
45
TBC1D8B Loss-of-Function Mutations Lead to X-Linked Nephrotic Syndrome via Defective Trafficking Pathways. ( 30661770 )
2019
46
Remission of nephrotic syndrome after resolution of renal artery stenosis in a patient with a single functional kidney. ( 30663976 )
2019
47
Population pharmacokinetics and dosage optimization of tacrolimus in pediatric patients with nephrotic syndrome
. ( 30663980 )
2019
48
Association of endothelin receptor type A rs5333 gene polymorphism with steroid response in Egyptian children with idiopathic nephrotic syndrome. ( 30672385 )
2019
49
Comment on: Bilateral combined central retinal artery and vein occlusion in a 3-year-old child with nephrotic syndrome. ( 30672510 )
2019
50
Retrobulbar Sinus Injection of Doxorubicin is More Efficient Than Lateral Tail Vein Injection at Inducing Experimental Nephrotic Syndrome in Mice: A Pilot Study. ( 30678519 )
2019

Variations for Nephrotic Syndrome

ClinVar genetic disease variations for Nephrotic Syndrome:

6 (show top 50) (show all 320)
# Gene Variation Type Significance SNP ID Assembly Location
1 TRPC6 NM_004621.5(TRPC6): c.523C> T (p.Arg175Trp) single nucleotide variant Uncertain significance rs869025541 GRCh38 Chromosome 11, 101504446: 101504446
2 TRPC6 NM_004621.5(TRPC6): c.523C> T (p.Arg175Trp) single nucleotide variant Uncertain significance rs869025541 GRCh37 Chromosome 11, 101375177: 101375177
3 LAMB2 NM_002292.3(LAMB2): c.5293G> A (p.Ala1765Thr) single nucleotide variant Benign/Likely benign rs74951356 GRCh38 Chromosome 3, 49121330: 49121330
4 LAMB2 NM_002292.3(LAMB2): c.5293G> A (p.Ala1765Thr) single nucleotide variant Benign/Likely benign rs74951356 GRCh37 Chromosome 3, 49158763: 49158763
5 LAMB2 NM_002292.3(LAMB2): c.4878G> A (p.Arg1626=) single nucleotide variant Conflicting interpretations of pathogenicity rs148648480 GRCh37 Chromosome 3, 49159422: 49159422
6 LAMB2 NM_002292.3(LAMB2): c.4878G> A (p.Arg1626=) single nucleotide variant Conflicting interpretations of pathogenicity rs148648480 GRCh38 Chromosome 3, 49121989: 49121989
7 LAMB2 NM_002292.3(LAMB2): c.4774C> T (p.Arg1592Trp) single nucleotide variant Benign/Likely benign rs61729458 GRCh38 Chromosome 3, 49122170: 49122170
8 LAMB2 NM_002292.3(LAMB2): c.4774C> T (p.Arg1592Trp) single nucleotide variant Benign/Likely benign rs61729458 GRCh37 Chromosome 3, 49159603: 49159603
9 LAMB2 NM_002292.3(LAMB2): c.4034G> A (p.Arg1345His) single nucleotide variant Conflicting interpretations of pathogenicity rs75073433 GRCh37 Chromosome 3, 49160755: 49160755
10 LAMB2 NM_002292.3(LAMB2): c.4034G> A (p.Arg1345His) single nucleotide variant Conflicting interpretations of pathogenicity rs75073433 GRCh38 Chromosome 3, 49123322: 49123322
11 LAMB2 NM_002292.3(LAMB2): c.3387A> G (p.Gln1129=) single nucleotide variant Benign/Likely benign rs34290943 GRCh37 Chromosome 3, 49161660: 49161660
12 LAMB2 NM_002292.3(LAMB2): c.3387A> G (p.Gln1129=) single nucleotide variant Benign/Likely benign rs34290943 GRCh38 Chromosome 3, 49124227: 49124227
13 LAMB2 NM_002292.3(LAMB2): c.2959G> A (p.Glu987Lys) single nucleotide variant Benign/Likely benign rs34759087 GRCh37 Chromosome 3, 49162284: 49162284
14 LAMB2 NM_002292.3(LAMB2): c.2959G> A (p.Glu987Lys) single nucleotide variant Benign/Likely benign rs34759087 GRCh38 Chromosome 3, 49124851: 49124851
15 LAMB2 NM_002292.3(LAMB2): c.2740G> A (p.Gly914Arg) single nucleotide variant Benign/Likely benign rs35713889 GRCh38 Chromosome 3, 49125150: 49125150
16 LAMB2 NM_002292.3(LAMB2): c.2740G> A (p.Gly914Arg) single nucleotide variant Benign/Likely benign rs35713889 GRCh37 Chromosome 3, 49162583: 49162583
17 LAMB2 NM_002292.3(LAMB2): c.1764C> T (p.Pro588=) single nucleotide variant Benign/Likely benign rs33942096 GRCh38 Chromosome 3, 49128787: 49128787
18 LAMB2 NM_002292.3(LAMB2): c.1764C> T (p.Pro588=) single nucleotide variant Benign/Likely benign rs33942096 GRCh37 Chromosome 3, 49166220: 49166220
19 LAMB2 NM_002292.3(LAMB2): c.1206G> A (p.Arg402=) single nucleotide variant Conflicting interpretations of pathogenicity rs201999373 GRCh38 Chromosome 3, 49130250: 49130250
20 LAMB2 NM_002292.3(LAMB2): c.1206G> A (p.Arg402=) single nucleotide variant Conflicting interpretations of pathogenicity rs201999373 GRCh37 Chromosome 3, 49167683: 49167683
21 LAMB2 NM_002292.3(LAMB2): c.1193C> T (p.Thr398Ile) single nucleotide variant Benign/Likely benign rs77500937 GRCh37 Chromosome 3, 49167696: 49167696
22 LAMB2 NM_002292.3(LAMB2): c.1193C> T (p.Thr398Ile) single nucleotide variant Benign/Likely benign rs77500937 GRCh38 Chromosome 3, 49130263: 49130263
23 LAMB2 NM_002292.3(LAMB2): c.306C> T (p.Asn102=) single nucleotide variant Benign/Likely benign rs79448908 GRCh37 Chromosome 3, 49169782: 49169782
24 LAMB2 NM_002292.3(LAMB2): c.306C> T (p.Asn102=) single nucleotide variant Benign/Likely benign rs79448908 GRCh38 Chromosome 3, 49132349: 49132349
25 PLCE1 NM_016341.3(PLCE1): c.513G> A (p.Val171=) single nucleotide variant Conflicting interpretations of pathogenicity rs61749239 GRCh38 Chromosome 10, 94031559: 94031559
26 PLCE1 NM_016341.3(PLCE1): c.513G> A (p.Val171=) single nucleotide variant Conflicting interpretations of pathogenicity rs61749239 GRCh37 Chromosome 10, 95791316: 95791316
27 PLCE1 NM_016341.3(PLCE1): c.810T> C (p.Cys270=) single nucleotide variant Benign rs17109671 GRCh38 Chromosome 10, 94031856: 94031856
28 PLCE1 NM_016341.3(PLCE1): c.810T> C (p.Cys270=) single nucleotide variant Benign rs17109671 GRCh37 Chromosome 10, 95791613: 95791613
29 PLCE1 NM_016341.3(PLCE1): c.960G> A (p.Glu320=) single nucleotide variant Benign rs17109674 GRCh37 Chromosome 10, 95791763: 95791763
30 PLCE1 NM_016341.3(PLCE1): c.960G> A (p.Glu320=) single nucleotide variant Benign rs17109674 GRCh38 Chromosome 10, 94032006: 94032006
31 PLCE1 NM_016341.3(PLCE1): c.1405T> A (p.Ser469Thr) single nucleotide variant Benign/Likely benign rs17508082 GRCh37 Chromosome 10, 95892129: 95892129
32 PLCE1 NM_016341.3(PLCE1): c.1405T> A (p.Ser469Thr) single nucleotide variant Benign/Likely benign rs17508082 GRCh38 Chromosome 10, 94132372: 94132372
33 PLCE1 NM_016341.3(PLCE1): c.1643G> T (p.Arg548Leu) single nucleotide variant Benign rs17417407 GRCh38 Chromosome 10, 94171330: 94171330
34 PLCE1 NM_016341.3(PLCE1): c.1643G> T (p.Arg548Leu) single nucleotide variant Benign rs17417407 GRCh37 Chromosome 10, 95931087: 95931087
35 PLCE1 NM_016341.3(PLCE1): c.1729G> A (p.Ala577Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs141639885 GRCh37 Chromosome 10, 95931173: 95931173
36 PLCE1 NM_016341.3(PLCE1): c.1729G> A (p.Ala577Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs141639885 GRCh38 Chromosome 10, 94171416: 94171416
37 PLCE1 NM_016341.3(PLCE1): c.2124G> A (p.Val708=) single nucleotide variant Benign/Likely benign rs61751496 GRCh38 Chromosome 10, 94234222: 94234222
38 PLCE1 NM_016341.3(PLCE1): c.2124G> A (p.Val708=) single nucleotide variant Benign/Likely benign rs61751496 GRCh37 Chromosome 10, 95993979: 95993979
39 PLCE1 NM_016341.3(PLCE1): c.3132C> T (p.His1044=) single nucleotide variant Benign/Likely benign rs61732522 GRCh37 Chromosome 10, 96012108: 96012108
40 PLCE1 NM_016341.3(PLCE1): c.3132C> T (p.His1044=) single nucleotide variant Benign/Likely benign rs61732522 GRCh38 Chromosome 10, 94252351: 94252351
41 PLCE1 NM_016341.3(PLCE1): c.4059C> T (p.Phe1353=) single nucleotide variant Benign/Likely benign rs61751499 GRCh37 Chromosome 10, 96025409: 96025409
42 PLCE1 NM_016341.3(PLCE1): c.4059C> T (p.Phe1353=) single nucleotide variant Benign/Likely benign rs61751499 GRCh38 Chromosome 10, 94265652: 94265652
43 PLCE1 NM_016341.3(PLCE1): c.4263G> A (p.Ser1421=) single nucleotide variant Benign/Likely benign rs41291134 GRCh38 Chromosome 10, 94265940: 94265940
44 PLCE1 NM_016341.3(PLCE1): c.4263G> A (p.Ser1421=) single nucleotide variant Benign/Likely benign rs41291134 GRCh37 Chromosome 10, 96025697: 96025697
45 PLCE1 NM_016341.3(PLCE1): c.4724G> C (p.Arg1575Pro) single nucleotide variant Benign rs2274224 GRCh38 Chromosome 10, 94279840: 94279840
46 PLCE1 NM_016341.3(PLCE1): c.4724G> C (p.Arg1575Pro) single nucleotide variant Benign rs2274224 GRCh37 Chromosome 10, 96039597: 96039597
47 PLCE1 NM_016341.3(PLCE1): c.5035+12C> A single nucleotide variant Benign rs3736901 GRCh38 Chromosome 10, 94284977: 94284977
48 PLCE1 NM_016341.3(PLCE1): c.5035+12C> A single nucleotide variant Benign rs3736901 GRCh37 Chromosome 10, 96044734: 96044734
49 PLCE1 NM_016341.3(PLCE1): c.5330C> T (p.Thr1777Ile) single nucleotide variant Benign rs3765524 GRCh38 Chromosome 10, 94298541: 94298541
50 PLCE1 NM_016341.3(PLCE1): c.5330C> T (p.Thr1777Ile) single nucleotide variant Benign rs3765524 GRCh37 Chromosome 10, 96058298: 96058298

Expression for Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for Nephrotic Syndrome

Pathways related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 NUP107 NUP205 NUP93
2 11.09 ITGA3 LAMB2 NPHS1 NPHS2 PLCE1 PTPRO
3 10.5 MAGI2 NPHS1

GO Terms for Nephrotic Syndrome

Cellular components related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 ALB APOA1 ARHGDIA ITGA3 LAMB2 NPHS1
2 nuclear pore GO:0005643 9.33 NUP107 NUP205 NUP93
3 extrinsic component of mitochondrial inner membrane GO:0031314 9.26 COQ6 COQ8B
4 nuclear periphery GO:0034399 9.13 NUP107 NUP205 NUP93
5 slit diaphragm GO:0036057 8.8 MAGI2 NPHS1 NPHS2

Biological processes related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 mRNA transport GO:0051028 9.71 NUP107 NUP205 NUP93
2 mRNA export from nucleus GO:0006406 9.7 NUP107 NUP205 NUP93
3 female gonad development GO:0008585 9.57 NUP107 SGPL1
4 adrenal gland development GO:0030325 9.56 APOA1 WT1
5 high-density lipoprotein particle remodeling GO:0034375 9.55 ALB APOA1
6 negative regulation of programmed cell death GO:0043069 9.51 ALB KANK2
7 nucleocytoplasmic transport GO:0006913 9.5 NUP107 NUP205 NUP93
8 ubiquinone biosynthetic process GO:0006744 9.49 COQ6 COQ8B
9 blood vessel endothelial cell migration GO:0043534 9.48 APOA1 EMP2
10 glomerular basement membrane development GO:0032836 9.46 NPHS1 WT1
11 glomerular visceral epithelial cell differentiation GO:0072112 9.43 PTPRO WT1
12 regulation of glomerular filtration GO:0003093 9.37 EMP2 PTPRO
13 nuclear pore complex assembly GO:0051292 9.33 NUP107 NUP205 NUP93
14 metanephric glomerular visceral epithelial cell development GO:0072249 9.26 LAMB2 NPHS2
15 glomerulus development GO:0032835 9.13 PLCE1 PTPRO WT1
16 glomerular visceral epithelial cell migration GO:0090521 9.1 KANK2
17 glomerular visceral epithelial cell development GO:0072015 8.62 MAGI2 NPHS1

Molecular functions related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 ALB APOA1 ARHGDIA COQ6 EMP2 ITGA3
2 integrin binding GO:0005178 9.33 EMP2 ITGA3 LAMB2
3 structural constituent of nuclear pore GO:0017056 9.13 NUP107 NUP205 NUP93

Sources for Nephrotic Syndrome

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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31 HGMD
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
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75 UMLS via Orphanet
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