MCID: NRV012
MIFTS: 31

Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Nervous System Benign Neoplasm

MalaCards integrated aliases for Nervous System Benign Neoplasm:

Name: Nervous System Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060115

Summaries for Nervous System Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Benign Neoplasm is related to autonomic nervous system benign neoplasm and sensory organ benign neoplasm. An important gene associated with Nervous System Benign Neoplasm is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Neuroscience and Glioblastoma Multiforme. Affiliated tissues include lung, brain and liver, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Nervous System Benign Neoplasm

Diseases in the Nervous System Cancer family:

Central Nervous System Benign Neoplasm Nervous System Benign Neoplasm
Central Nervous System Cancer

Diseases related to Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 autonomic nervous system benign neoplasm 33.9 ENO2 NF1 SYP
2 sensory organ benign neoplasm 32.2 ENO2 SYP
3 ganglioneuroma 32.0 ENO2 GFAP SYP
4 central nervous system benign neoplasm 31.7 CCM2 ENO2 GFAP ITGB1BP1 KRIT1 PDCD10
5 neuroma 31.6 ENO2 GFAP LZTR1 NF2 SMARCB1 TRPV1
6 hemangioblastoma 30.5 ENO2 GFAP SYP
7 papilloma of choroid plexus 30.3 GFAP SYP TP53
8 gangliocytoma 11.1
9 schwannomatosis 1 10.3 NF2 SMARCB1
10 intraventricular meningioma 10.3 GFAP NF2
11 duodenal somatostatinoma 10.3 ENO2 NF1
12 malignant glandular tumor of peripheral nerve sheath 10.3 NF1 SYP
13 pancreatic somatostatinoma 10.3 ENO2 SYP
14 extrahepatic bile duct adenocarcinoma 10.3 ENO2 SYP
15 orbital cancer 10.3 ENO2 SYP
16 middle ear adenoma 10.3 ENO2 SYP
17 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
18 gallbladder small cell carcinoma 10.3 ENO2 SYP
19 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
20 small cell carcinoma of the bladder 10.3 ENO2 SYP
21 papillary tumor of the pineal region 10.3 ENO2 SYP
22 cerebellar medulloblastoma 10.3 ENO2 GFAP
23 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 GFAP
24 chordoid meningioma 10.3 GFAP SYP
25 chiari malformation 10.3 GFAP SYP
26 human venous malformation 10.3 CCM2 KRIT1 PDCD10
27 intracranial structure hemangioma 10.3 KRIT1 SNRPB
28 gastric leiomyosarcoma 10.3 ENO2 KIT
29 brain angioma 10.3 KRIT1 SNRPB
30 protoplasmic astrocytoma 10.3 GFAP TP53
31 cerebral angioma 10.3 KRIT1 SNRPB
32 mixed type thymoma 10.2 KIT SYP
33 vascular hemostatic disease 10.2 CCM2 KRIT1 SNRPB
34 carotid body cancer 10.2 ENO2 SYP
35 meningothelial meningioma 10.2 ENO2 NF2 SNRPB
36 klippel-trenaunay-weber syndrome 10.2 CCM2 KRIT1 PDCD10
37 malignant sertoli cell tumor 10.2 ENO2 SYP
38 monosomy 22 10.2 NF2 SMARCB1
39 spinal meningioma 10.2 ENO2 NF1 NF2
40 spinal canal and spinal cord meningioma 10.2 ENO2 NF1 NF2
41 epithelioid malignant peripheral nerve sheath tumor 10.2 ENO2 NF1 SMARCB1
42 rhabdoid meningioma 10.2 GFAP NF2 SMARCB1
43 venous malformations, multiple cutaneous and mucosal 10.2 CCM2 KRIT1 PDCD10
44 desmoplastic infantile ganglioglioma 10.2 GFAP SYP
45 extraventricular neurocytoma 10.2 GFAP SYP
46 trigeminal nerve neoplasm 10.2 GFAP NF1 NF2
47 neurilemmoma of the fifth cranial nerve 10.2 GFAP NF1 NF2
48 hemangioma of liver 10.2 CD34 KRIT1
49 psammomatous meningioma 10.2 CD34 NF2
50 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Nervous System Benign Neoplasm:



Diseases related to Nervous System Benign Neoplasm

Symptoms & Phenotypes for Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.8 NF2 SMARCB1 TP53

MGI Mouse Phenotypes related to Nervous System Benign Neoplasm:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.38 CCM2 ENO2 GFAP KIT NF1 NF2
2 growth/size/body region MP:0005378 10.36 CCM2 ENO2 GFAP ITGB1BP1 KIT KRIT1
3 cardiovascular system MP:0005385 10.3 CCM2 GFAP KIT KRIT1 NF1 PDCD10
4 cellular MP:0005384 10.29 CCM2 CD34 ENO2 GFAP KIT NF1
5 homeostasis/metabolism MP:0005376 10.29 CCM2 CD34 GFAP KIT LZTR1 NF1
6 mortality/aging MP:0010768 10.22 CCM2 GFAP ITGB1BP1 KIT KRIT1 LZTR1
7 hematopoietic system MP:0005397 10.19 CCM2 CD34 KIT LZTR1 NF1 PDCD10
8 embryo MP:0005380 10.18 CCM2 KIT KRIT1 NF1 NF2 PDCD10
9 integument MP:0010771 10.16 CCM2 CD34 KIT KRIT1 NF1 NF2
10 craniofacial MP:0005382 10.14 CCM2 ENO2 ITGB1BP1 KIT KRIT1 NF1
11 nervous system MP:0003631 10.1 CCM2 ENO2 GFAP KIT KRIT1 NF1
12 neoplasm MP:0002006 10.02 CD34 KIT KRIT1 NF1 NF2 PDCD10
13 liver/biliary system MP:0005370 9.98 KIT NF1 NF2 SMARCB1 TP53 TRPV1
14 muscle MP:0005369 9.97 CCM2 GFAP KIT KRIT1 NF1 PDCD10
15 normal MP:0002873 9.81 CCM2 GFAP ITGB1BP1 KIT NF1 PDCD10
16 renal/urinary system MP:0005367 9.5 KIT NF1 NF2 PDCD10 TP53 TRPV1
17 vision/eye MP:0005391 9.32 CCM2 GFAP ITGB1BP1 KIT KRIT1 NF1

Drugs & Therapeutics for Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Nervous System Benign Neoplasm

Genetic Tests for Nervous System Benign Neoplasm

Anatomical Context for Nervous System Benign Neoplasm

MalaCards organs/tissues related to Nervous System Benign Neoplasm:

41
Lung, Brain, Liver, Ovary, Spinal Cord, Pineal, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Benign Neoplasm:

19
The Central Nervous System Or

Publications for Nervous System Benign Neoplasm

Variations for Nervous System Benign Neoplasm

Expression for Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Nervous System Benign Neoplasm.

Pathways for Nervous System Benign Neoplasm

Pathways related to Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.09 ENO2 GFAP NF1 NF2 SYP
2 10.97 NF1 NF2 TP53 TSC2
3 10.76 STK26 TP53 TSC2
4 10.4 RAP1B TSC2

GO Terms for Nervous System Benign Neoplasm

Cellular components related to Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.97 ENO2 GFAP ITGB1BP1 NF1 NF2 PDCD10
2 membrane GO:0016020 9.86 CD34 ENO2 GFAP ITGB1BP1 KIT KRIT1
3 cytoplasm GO:0005737 9.5 CCM2 CD34 ENO2 GFAP ITGB1BP1 KIT
4 cell periphery GO:0071944 9.43 CD34 ITGB1BP1 STK26

Biological processes related to Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.63 ITGB1BP1 NF1 NF2 SMARCB1 TP53 TSC2
2 negative regulation of cell migration GO:0030336 9.56 NF1 NF2 RAP2A STK26
3 cellular response to drug GO:0035690 9.54 RAP1B RAP2A TP53
4 positive regulation of Notch signaling pathway GO:0045747 9.5 ITGB1BP1 KIT PDCD10
5 Rap protein signal transduction GO:0032486 9.4 RAP1B RAP2A
6 negative regulation of protein kinase activity GO:0006469 9.26 ITGB1BP1 NF1 NF2 TSC2
7 microvillus assembly GO:0030033 8.8 RAP1B RAP2A STK26

Sources for Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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