MCID: NRV007
MIFTS: 71

Nervous System Disease

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 15 17
Abnormality of the Nervous System 6
Nervous System Diseases 45
Nervous System Disorder 74

Classifications:



External Ids:

Disease Ontology 12 DOID:863
ICD9CM 36 349.9
MeSH 45 D009422
NCIt 51 C26835
UMLS 74 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to peripheral nervous system disease and central nervous system disease, and has symptoms including seizures, ataxia and tremor. An important gene associated with Nervous System Disease is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 35.0 IL6 MOG TNF
2 central nervous system disease 35.0 CCR1 CXCR3 GC IFNG IL1B IL6
3 meningitis 32.8 IFNG IL1B IL6 MMP9 TNF
4 multiple sclerosis 32.8 CCR1 CXCR3 IFNG IL1B IL6 MMP9
5 stomatitis 31.0 CSF2 IL1B TNF
6 hematopoietic stem cell transplantation 30.9 IFNG IL6 TNF
7 arthritis 30.9 CSF2 IFNG IL1B IL6 MMP9 TNF
8 acquired immunodeficiency syndrome 30.8 CSF2 IFNG IL1B IL6 TNF
9 human immunodeficiency virus infectious disease 30.7 IFNG IL6 TNF
10 central nervous system vasculitis 30.6 IFNG IL1B IL6 TNF
11 myocardial infarction 30.6 IL1B IL6 MIAT MMP9 TNF
12 chlamydia 30.6 IFNG IL1B IL6 NOS2 TNF
13 toxoplasmosis 30.6 IFNG IL1B IL6 TNF
14 colitis 30.6 IFNG IL1B IL6 NOS2 TNF
15 mouth disease 30.5 IFNG IL1B IL6 TNF
16 aseptic meningitis 30.5 IFNG IL1B TNF
17 inflammatory bowel disease 30.4 IFNG IL1B IL6 TNF
18 autonomic nervous system disease 12.4
19 amyotrophic lateral sclerosis 1 11.4
20 neuropathy 11.2
21 autonomic peripheral neuropathy 11.2
22 central hypoventilation syndrome, congenital 11.2
23 neuromyelitis optica 11.2
24 hyperekplexia 11.2
25 neuroleptic malignant syndrome 11.2
26 cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome 10.9
27 amyotrophy, hereditary neuralgic 10.8
28 arthrogryposis multiplex congenita, neurogenic type 10.8
29 encephalopathy, acute, infection-induced 8 10.8
30 granulomatous amebic encephalitis 10.8
31 restless legs syndrome 10.8
32 spinocerebellar ataxia type 1 with axonal neuropathy 10.8
33 intracranial abscess 10.8
34 meningoencephalitis 10.8
35 hemiplegia 10.8
36 epidural abscess 10.8
37 subdural empyema 10.8
38 cauda equina syndrome 10.8
39 locked-in syndrome 10.8
40 toxic encephalopathy 10.8
41 gerstmann syndrome 10.8
42 neuronitis 10.8
43 periodontitis, chronic 10.8 IL1B IL6
44 critical limb ischemia 10.8 IL6 TNF
45 juvenile ankylosing spondylitis 10.8 IL6 TNF
46 b-cell growth factor 10.8 IFNG IL6
47 diabetic foot ulcers 10.8 IL6 MMP9
48 cardiogenic shock 10.8 IL6 TNF
49 streptococcal toxic-shock syndrome 10.8 IL6 TNF
50 acute transverse myelitis 10.8 IL6 MMP9

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:


seizures, ataxia, tremor, myoclonus, gait ataxia, back pain, ophthalmoplegia, vertigo, pain, agitation, headache, clumsiness, involuntary movements, dysdiadochokinesis, action tremor, bradykinesia, hemiplegia, torticollis, muscle fibrillation, syncope, hyperesthesia, athetosis, hemiparesis, opisthotonus, cogwheel rigidity, dysesthesia, chronic pain, sciatica, scalp tenderness, hyperalgesia, cheyne-stokes respiration, hoarseness, vertigo/dizziness, equilibration disorder, sleeplessness, muscular fasciculation, muscle rigidity, symptoms, muscle spasticity, spasm, cerebellar ataxia, numbness, numbness localized, agitation mental, numb mouth, clouded consciousness, meningism, reflex, abnormal, spasmodic torticollis, dizziness, akathisia, neuralgia, adiadochokinesis, asterixis, decreased tendon reflex, musculoskeletal symptom, circumoral paresthesia, pathological conditions, signs and symptoms, asynergia, dyskinesia neonatal, staggering gait, non-epileptic convulsion, absence attacks, lid retraction, micropsia, leg cramps, lassitude, spasm oropharyngeal, aphonia, flaccid muscle tone, flaccid paralysis, burning sensation, hypalgesia, lightheadedness, muscular stiffness, muscular incoordination, fine tremor, coarse tremor, epileptic aura, astasia, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, bulging fontanelle, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, limb, tremor, muscle, nerve tremors, tremor, neonatal, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, tonic seizures, extreme exhaustion, rigor - temperature-associated observation, burning mucosal, paresthesia mouth, eyes rolling, electric shock sensation, jaw stiffness, muzzy headed, motor restlessness, myotonus (finding), reaction to spinal or lumbar puncture, headache fullness

MGI Mouse Phenotypes related to Nervous System Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 CCR1 CSF2 CXCR3 IFNG IL1B IL6
2 hematopoietic system MP:0005397 10.25 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
3 homeostasis/metabolism MP:0005376 10.22 CCR1 CCR6 CSF2 CXCR3 GC IFNG
4 cellular MP:0005384 10.2 CCR1 CSF2 CXCR3 IFNG IL6 MMP9
5 immune system MP:0005387 10.18 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
6 integument MP:0010771 9.97 CSF2 IFNG IL1B IL6 MMP9 MTDH
7 neoplasm MP:0002006 9.85 CSF2 CXCR3 IFNG IL1B IL6 MMP9
8 liver/biliary system MP:0005370 9.8 CCR1 IFNG IL6 MTDH NOS2 TBK1
9 renal/urinary system MP:0005367 9.56 CCR1 CSF2 CXCR3 IFNG IL6 MMP9
10 respiratory system MP:0005388 9.23 CCR1 CSF2 CXCR3 IFNG IL6 MMP9

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1431)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
2
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
3
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
5
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 13422-51-0 15589840 11953898
6
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 13422-55-4
7
Metformin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 657-24-9 14219 4091
8
Glucagon Approved Phase 4,Phase 2,Phase 1,Not Applicable 16941-32-5
9
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 60142-96-3 3446
10
Rivastigmine Approved, Investigational Phase 4,Phase 1 123441-03-2 77991
11
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
12
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
13
Chloroprocaine Approved Phase 4 133-16-4 8612
14
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
15
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
16
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-78-2 2244
17
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6740-88-1 3821
18
Etomidate Approved Phase 4,Phase 3,Not Applicable 33125-97-2 667484 36339
19
Clobazam Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22316-47-8 2789
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
21
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
22
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
23
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
24
Clonazepam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1622-61-3 2802
25
Imipramine Approved Phase 4 50-49-7 3696
26
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
27
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
28
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99-66-1 3121
29
Phenobarbital Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-06-6 4763
30
Levetiracetam Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 102767-28-2 441341
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 113775-47-6 5311068 68602
32
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
33
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-92-7 6047
34
Rotigotine Approved Phase 4,Phase 2 99755-59-6, 92206-54-7 57537
35
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
36
Cisatracurium Approved Phase 4,Phase 3,Phase 2,Not Applicable 96946-41-7
37
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 68-04-2
38
Atracurium Approved, Experimental, Investigational Phase 4,Phase 3,Not Applicable 64228-79-1 47319
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 437-38-7 3345
40
Rocuronium Approved Phase 4,Phase 1,Phase 2,Not Applicable 119302-91-9, 143558-00-3 441290
41
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
42
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
43
Timolol Approved Phase 4,Phase 2,Phase 1,Not Applicable 26839-75-8 5478 33624
44
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 57-27-2 5288826
45
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 6251 453
46
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 38396-39-3, 2180-92-9 2474
47
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
48
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 378-44-9 9782
49
Curcumin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 1 458-37-7 969516
50
Mineral oil Approved, Vet_approved Phase 4,Phase 3 8042-47-5

Interventional clinical trials:

(show top 50) (show all 10264)
# Name Status NCT ID Phase Drugs
1 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
2 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
3 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
4 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4 vitamin B12
5 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
6 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
7 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
8 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
9 Cognitive Decline in Non-demented PD Unknown status NCT01340885 Phase 4 Strattera;Exelon
10 ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study Unknown status NCT01881711 Phase 4
11 Anesthesia Induction in Patients Undergoing Surgery for Cervical Myelopathy Unknown status NCT01052337 Phase 4 anaesthetics: sevofluorane
12 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
13 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
14 Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Unknown status NCT01650792 Phase 4 Aspirin
15 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
16 Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
17 Oxepa in Multiple Trauma Unknown status NCT01099501 Phase 4
18 Effects of Perampanel on Cognition and Electroencephalography in Patients With Epilepsy Unknown status NCT02900755 Phase 4 Perampanel
19 Clobazam Adjunctive Treatment of Adults With Refractory Focal Epilepsy Unknown status NCT02726919 Phase 4 Clobazam
20 Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody Unknown status NCT02695797 Phase 4 Prednisolone
21 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
22 Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy Unknown status NCT01932502 Phase 4 clobazam (Onfi);Initial conversion and titration;Conversion schedule - Week 1;Conversion schedule - Week 2;Conversion schedule - Week 3
23 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
24 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
25 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
26 Hormone Profiles in Adults With Newly Diagnosed Epilepsy Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
27 Study to Improve the Treatment of Epilepsy (SITE) Unknown status NCT00133081 Phase 4 All registered antiepileptic drugs
28 Efficacy of Levetiracetam in Control of Neonatal Seizures Guided by an EEG Unknown status NCT03107507 Phase 4 Levetiracetam;Phenobarbital
29 "Equistasi" and Gait in Hemiparesis Unknown status NCT02714478 Phase 4
30 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
31 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
32 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
33 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
34 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
35 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
36 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
37 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Unknown status NCT03098368 Phase 4 Rotigotine;Placebo
38 Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus Unknown status NCT02518789 Phase 4 Low-dose Dexmedetomidine;High-dose dexmedetomidine;normal saline;Etomidate;midazolam,fentanyl,rocuronium;propofol,remifentanil,cis atracurium
39 The Effect of no Muscle Relaxant Versus Reduced-dose Rocuronium on Anesthesia in Adenotonsillectomy Unknown status NCT02467595 Phase 4 Rocuronium bromide 0.15 mg kg-1;Rocuronium bromide 0.3 mg kg-1;Fentanyl;Propofol;Sevoflurane
40 Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia Unknown status NCT02141737 Phase 4 Lidocaine Hydrochloride Injection;Etomidate Fat Emulsion Injection;normal saline;Midazolam Injection;Fentanyl Citrate Injection;Rocuronium Injection
41 Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study Unknown status NCT02836743 Phase 4 Circadin;Placebo
42 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
43 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
44 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
45 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
46 A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks Unknown status NCT03159000 Phase 4 Saline
47 Migraine Prophylaxis With Clopidogrel Trial Unknown status NCT02938182 Phase 4 clopidogrel
48 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
49 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
50 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Anatomical Context for Nervous System Disease

MalaCards organs/tissues related to Nervous System Disease:

42
Brain, Spinal Cord, Testes, Bone, Eye, Heart, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Disease:

20
The Central Nervous System Or

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 367)
# Title Authors Year
1
Adenovirus-Associated Central Nervous System Disease in Children. ( 30413311 )
2019
2
Potential widespread denitrosylation of brain proteins following prolonged restraint: proposed links between stress and central nervous system disease. ( 30414012 )
2019
3
Mycophenolate mofetil in the treatment of pediatric autoimmune central nervous system disease. ( 30474195 )
2019
4
Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection. ( 30707437 )
2019
5
Expanding the central nervous system disease spectrum associated with FLNC mutation. ( 30734317 )
2019
6
Immune-Mediated Central Nervous System Disease-Current Knowledge and Recommendations. ( 30808493 )
2019
7
Application of virus targeting nano-carrier drug delivery system in virus-induced central nervous system diseases treatment. ( 31067406 )
2019
8
Review: Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions. ( 29927108 )
2019
9
Is the Eye an Extension of the Brain in Central Nervous System Disease? ( 28609158 )
2018
10
Production of transgenic pigs using a pGFAP-CreERT2/EGFP LoxP inducible system for central nervous system disease models. ( 29284207 )
2018
11
Predicting the incidence and timing of central nervous system disease in metastatic melanoma: Implications for surveillance and preventative therapy. ( 29332716 )
2018
12
A matrix metalloproteinase 9 (MMP9) gene single nucleotide polymorphism is associated with predisposition to tick-borne encephalitis virus-induced severe central nervous system disease. ( 29496490 )
2018
13
Infliximab-Associated Chronic Inflammatory Central Nervous System Disease and Peroneal Nerve Injury in a Psoriatic Patient Refractory to Treatment: Case Report with 10-Year Follow-Up. ( 29515419 )
2018
14
Stem cells in the treatment of central nervous system disease. ( 29523970 )
2018
15
Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation. ( 30013417 )
2018
16
Rat Lungworm Infection Associated with Central Nervous System Disease - Eight U.S. States, January 2011-January 2017. ( 30070981 )
2018
17
MicroRNAs of microglia: Wrestling with central nervous system disease. ( 30323123 )
2018
18
Testing for Bartonella ssp. DNA in cerebrospinal fluid of dogs with inflammatory central nervous system disease. ( 30381844 )
2018
19
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease. ( 30537919 )
2018
20
Expression of microRNAs in cerebrospinal fluid of dogs with central nervous system disease. ( 30563542 )
2018
21
AAVrh10 Gene Therapy Ameliorates Central and Peripheral Nervous System Disease in Canine Globoid Cell Leukodystrophy (Krabbe Disease). ( 29316812 )
2018
22
The Challenge to Search for New Nervous System Disease Biomarker Candidates: the Opportunity to Use the Proteogenomics Approach. ( 30554402 )
2018
23
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. ( 28075486 )
2017
24
Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. ( 28288111 )
2017
25
Wasp Venom Immunotherapy in a Patient With Immune-Mediated Inflammatory Central Nervous System Disease: Is it Safe? ( 28398199 )
2017
26
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers. ( 28429106 )
2017
27
Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. ( 28453910 )
2017
28
Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study. ( 28471963 )
2017
29
Central Nervous System Disease, Education, and Race Impact Radiation Refusal in Pediatric Cancer Patients. ( 28538508 )
2017
30
Central nervous system disease in pediatric acute myeloid leukemia. ( 28853216 )
2017
31
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection. ( 28927234 )
2017
32
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. ( 28933846 )
2017
33
Editorial: Induction of Central Nervous System Disease by the Adaptive Immune Response. ( 29038655 )
2017
34
Central Nervous System Disease in Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. ( 29061243 )
2017
35
Immunotherapeutics in Pediatric Autoimmune Central Nervous System Disease: Agents and Mechanisms. ( 29103429 )
2017
36
Focused ultrasound treatment for central nervous system disease: neurosurgeon's perspectives. ( 30603157 )
2017
37
Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease. ( 28685189 )
2017
38
Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. ( 26447927 )
2016
39
Hodgkin Lymphoma With Central Nervous System Disease at Primary Presentation. ( 26814676 )
2016
40
Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease. ( 26831951 )
2016
41
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses. ( 26861818 )
2016
42
Central nervous system disease in childhood acute lymphoblastic leukaemia- a review. ( 26990196 )
2016
43
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia. ( 26997880 )
2016
44
The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. ( 27133811 )
2016
45
Glial biomarkers in human central nervous system disease. ( 27228454 )
2016
46
AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis. ( 27354217 )
2016
47
Delivery of an Adeno-Associated Virus Vector into Cerebrospinal Fluid Attenuates Central Nervous System Disease in Mucopolysaccharidosis Type II Mice. ( 27510804 )
2016
48
Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. ( 27563314 )
2016
49
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. ( 27608169 )
2016
50
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease). ( 27638585 )
2016

Variations for Nervous System Disease

ClinVar genetic disease variations for Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;X;t(Y;3)(p11.2;p12.3)dn Translocation Likely pathogenic
2 46;XY;t(1;3)(q32.3;q21.1) Translocation Uncertain significance

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCR1 CCR6 CSF2 IFNG IL1B IL6
2
Show member pathways
13.7 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
3
Show member pathways
13.41 CCR1 CCR6 CSF2 CXCR3 IL1B IL6
4
Show member pathways
13.37 CCR1 CSF2 IFNG IL1B IL6 MMP9
5
Show member pathways
13.32 CCR1 CCR6 CSF2 CXCR3 IL1B IL6
6
Show member pathways
13.12 IFNG IL1B IL6 NOS2 TBK1 TNF
7
Show member pathways
12.98 CCR1 CSF2 IL1B IL6 MMP9 TBK1
8
Show member pathways
12.78 IFNG IL1B IL6 TBK1 TNF
9
Show member pathways
12.61 IFNG IL1B IL6 NOS2 TNF
10
Show member pathways
12.59 CSF2 IFNG IL1B IL6 TNF
11
Show member pathways
12.36 IFNG IL1B IL6 SERPINA3 TNF
12
Show member pathways
12.34 IFNG IL1B IL6 NOS2 TNF
13
Show member pathways
12.28 IFNG IL1B NOS2 TNF
14 12.27 CSF2 IL6 MMP9 PROM1
15 12.27 IFNG IL1B IL6 NOS2 TNF
16
Show member pathways
12.24 IL1B IL6 NOS2 TNF
17
Show member pathways
12.23 IFNG IL1B IL6 NOS2 TNF
18
Show member pathways
12.22 CCR1 CCR6 CXCR3 IL1B MMP9
19 12.22 IFNG IL6 MMP9 NOS2 TNF
20
Show member pathways
12.2 CSF2 IFNG IL1B IL6 MMP9 TBK1
21 12.12 IFNG IL1B MMP9 TNF
22
Show member pathways
12.08 IFNG IL1B IL6 TNF
23 12.04 CCR1 CSF2 IFNG IL6 TNF
24 12.02 IL1B IL6 MMP9 NOS2 TNF
25
Show member pathways
12.01 CSF2 IFNG IL1B IL6 MMP9 TNF
26 12 CSF2 IL1B IL6 MMP9 TNF
27 11.92 CSF2 IL1B IL6 TNF
28 11.92 IFNG IL1B IL6 MMP9 NOS2 TNF
29 11.9 IFNG IL6 NOS2
30 11.9 IL1B IL6 TNF
31 11.88 CSF2 IFNG IL1B IL6 TNF
32 11.84 CSF2 IFNG IL1B IL6 NOS2
33 11.81 CSF2 IFNG IL6
34 11.8 IL1B IL6 NOS2 TNF
35 11.8 CCR6 CXCR3 IFNG IL1B TNF
36
Show member pathways
11.77 CSF2 IFNG TNF
37 11.74 CSF2 IFNG IL1B IL6 TNF
38 11.72 CSF2 IFNG IL1B IL6 NOS2 TNF
39 11.65 CSF2 IL1B IL6 MMP9 TNF
40 11.61 IFNG IL6 NOS2
41 11.61 IL1B IL6 TNF
42 11.59 IFNG IL1B IL6 TNF
43 11.57 IFNG IL6 TNF
44 11.57 IFNG IL1B NOS2 TNF
45 11.54 IL6 MMP9 TNF
46 11.54 IFNG IL1B TNF
47 11.54 CSF2 IL1B IL6
48 11.54 IFNG IL1B IL6 TNF
49 11.49 CCR1 CSF2 IL1B IL6 TNF
50 11.42 IFNG IL1B IL6 TNF

GO Terms for Nervous System Disease

Cellular components related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 CCR1 CCR6 CXCR3 MOG TNF
2 extracellular space GO:0005615 9.28 CSF2 GC IFNG IL1B IL6 MMP9

Biological processes related to Nervous System Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.93 IFNG IL1B MMP9 TNF
2 negative regulation of gene expression GO:0010629 9.93 CCR1 IFNG NOS2 TBK1 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1B MTDH TBK1 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 IL1B IL6 MTDH TNF
5 defense response to Gram-positive bacterium GO:0050830 9.86 IL6 TBK1 TNF
6 calcium-mediated signaling GO:0019722 9.85 CCR1 CCR6 CXCR3
7 cell chemotaxis GO:0060326 9.85 CCR1 CCR6 CXCR3
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL6 TBK1 TNF
9 chemokine-mediated signaling pathway GO:0070098 9.84 CCR1 CCR6 CXCR3
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 CSF2 IFNG IL6
11 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TNF
12 cellular response to lipopolysaccharide GO:0071222 9.8 CSF2 IL1B IL6 NOS2 TNF
13 inflammatory response GO:0006954 9.8 CCR1 CXCR3 IL1B IL6 SERPINA3 TBK1
14 positive regulation of cytosolic calcium ion concentration GO:0007204 9.78 CCR1 CCR6 CXCR3
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IFNG IL1B TNF
16 immune response GO:0006955 9.76 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 CSF2 IL1B TNF
18 regulation of insulin secretion GO:0050796 9.73 IFNG IL1B NOS2 TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 IL1B MTDH TNF
20 negative regulation of neurogenesis GO:0050768 9.69 IL1B IL6 TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
22 positive regulation of podosome assembly GO:0071803 9.67 CSF2 TNF
23 positive regulation of osteoclast differentiation GO:0045672 9.67 CCR1 IFNG TNF
24 humoral immune response GO:0006959 9.67 CCR6 IFNG IL6 TNF
25 negative regulation of lipid storage GO:0010888 9.66 IL6 TNF
26 response to glucocorticoid GO:0051384 9.65 IL6 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
28 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B IL6 TNF
29 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IFNG IL1B TNF
31 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
32 positive regulation of interleukin-23 production GO:0032747 9.61 CSF2 IFNG
33 positive regulation of killing of cells of other organism GO:0051712 9.58 IFNG NOS2
34 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
35 positive regulation of vitamin D biosynthetic process GO:0060557 9.52 IFNG TNF
36 positive regulation of neuroinflammatory response GO:0150078 9.5 IL1B IL6 TNF
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.28 TNF
38 cytokine-mediated signaling pathway GO:0019221 9.17 CCR1 CSF2 IL1B IL6 MMP9 NOS2
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.13 IFNG IL1B TNF
40 regulation of signaling receptor activity GO:0010469 10.05 CSF2 IFNG IL1B IL6 TNF
41 positive regulation of gene expression GO:0010628 10.04 CSF2 IFNG IL1B IL6 TNF

Molecular functions related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.5 CCR1 CCR6 CXCR3
2 C-C chemokine binding GO:0019957 9.43 CCR1 CCR6 CXCR3
3 C-C chemokine receptor activity GO:0016493 9.33 CCR1 CCR6 CXCR3
4 chemokine receptor activity GO:0004950 9.13 CCR1 CCR6 CXCR3
5 cytokine activity GO:0005125 9.02 CSF2 IFNG IL1B IL6 TNF

Sources for Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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