Nervous System Disease

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 15 17
Abnormality of the Nervous System 6
Nervous System Diseases 43
Nervous System Disorder 71


External Ids:

Disease Ontology 12 DOID:863
ICD9CM 34 349.9
MeSH 43 D009422
NCIt 49 C26835
SNOMED-CT 67 118940003
UMLS 71 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to central nervous system disease and peripheral nervous system disease, and has symptoms including seizures, ataxia and myoclonus. An important gene associated with Nervous System Disease is ANKRD11 (Ankyrin Repeat Domain 11), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Etomidate and Oseltamivir have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, peripheral nervous system and brain, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Infectious Disease of the Nervous System

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1326)
# Related Disease Score Top Affiliating Genes
1 central nervous system disease 35.9 TNF TBK1 SERPINA3 PROM1 NOS2 MOG
2 peripheral nervous system disease 35.6 TNF SERPINA3 MOG IL6 IL1B IFNG
3 amyotrophic lateral sclerosis 1 33.9 TNF TBK1 SERPINA3 IL6 IL1B H2AC18
4 neuromyelitis optica 33.6 MOG IL6 IL1B
5 multiple sclerosis 33.6 TNF NOS2 MOG MMP9 IL6 IL1B
6 meningitis 33.6 TNF MMP9 IL6 IL1B IFNG CSF2
7 meningoencephalitis 33.5 TNF SERPINA3 IL6 IL1B CCR6
8 toxic encephalopathy 33.0 TNF SERPINA3 IL6 IL1B H2AC18
9 guillain-barre syndrome 32.3 TNF MOG CCR6
10 acute disseminated encephalomyelitis 32.2 MOG IL1B CCR6
11 encephalitis 32.0 TNF NOS2 MOG IL6 IL1B
12 systemic lupus erythematosus 31.9 TNF MMP9 IL6 IL1B IFNG H2AC18
13 autoimmune disease 31.9 TNF MOG MMP9 IL6 IL1B IFNG
14 demyelinating disease 31.9 TNF SERPINA3 MOG MMP9 IL6 IL1B
15 leukemia, acute myeloid 31.8 TNF SERPINA3 PROM1 MMP9 MIR199A1 IL6
16 acquired immunodeficiency syndrome 31.7 TNF NOS2 IL6 IL1B IFNG CSF2
17 neuritis 31.7 TNF MOG MMP9 IL6 IL1B IFNG
18 immune deficiency disease 31.7 TNF SERPINA3 IL6 IFNG H2AC18 CXCR3
19 measles 31.7 TNF IL6 IL1B IFNG
20 histiocytosis 31.7 TNF SERPINA3 IFNG CSF2 CCR6
21 bacterial meningitis 31.6 TNF MMP9 IL6 IL1B IFNG CSF2
22 viral encephalitis 31.6 TNF MOG IL6 IL1B CCR6
23 migraine with or without aura 1 31.6 TNF MMP9 IL6 IL1B H2AC18
24 optic neuritis 31.6 TNF MOG IL6 IL1B CXCR3
25 stomatitis 31.6 TNF IL6 IL1B IFNG CSF2
26 myelitis 31.5 TNF MOG MMP9 IL6 CCR6
27 toxoplasmosis 31.5 TNF NOS2 IL6 IL1B IFNG
28 subacute sclerosing panencephalitis 31.5 TNF MOG IL6 IFNG
29 spinal cord injury 31.5 TNF NOS2 MMP9 IL6
30 aseptic meningitis 31.5 TNF IL1B IFNG
31 cerebrovascular disease 31.5 TNF SERPINA3 MMP9 MIR199A1 IL6
32 langerhans cell histiocytosis 31.5 IFNG CSF2 CCR6
33 lysosomal storage disease 31.4 TNF SERPINA3 MIR199A1 IL6 H2AC18 CCR6
34 chickenpox 31.4 TNF IL6 IFNG CCR6
35 cerebral palsy 31.4 TNF NOS2 IL6 IL1B
36 optic nerve disease 31.4 TNF SERPINA3 MOG IL6 IL1B CRYAA
37 cryptococcal meningitis 31.4 IFNG CSF2 CCR6
38 sarcoidosis 1 31.4 TNF SERPINA3 IL1B IFNG CXCR3 CCR6
39 psoriatic arthritis 31.3 TNF IL6 IL1B IFNG CCR6
40 myeloma, multiple 31.3 TNF SERPINA3 MMP9 MIR199A1 IL6 IL1B
41 relapsing-remitting multiple sclerosis 31.3 TNF MOG MMP9 IL6 IL1B IFNG
42 trypanosomiasis 31.3 TNF NOS2 IL6 IL1B IFNG CXCR3
43 central nervous system lymphoma 31.3 TNF IL6 CCR6
44 vascular disease 31.3 TNF NOS2 MMP9 MIR199A1 IL6 IFNG
45 spinal cord disease 31.3 TNF MOG IL6 IL1B H2AC18 CCR6
46 prion disease 31.3 SERPINA3 IL1B H2AC18 CRYAA
47 viral meningitis 31.3 IL6 IFNG CXCR3
48 bacterial sepsis 31.2 TNF NOS2 IL6 IL1B CCR6
49 toxic shock syndrome 31.2 TNF NOS2 IL6 IL1B IFNG
50 vascular dementia 31.2 TNF SERPINA3 MMP9 IL6 IL1B

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:

Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:

seizures, ataxia, myoclonus, tremor, back pain, ophthalmoplegia, vertigo, involuntary movements, dysdiadochokinesis, headache, gait ataxia, torticollis, clumsiness, syncope, hyperesthesia, hemiparesis, athetosis, hemiplegia, cogwheel rigidity, scalp tenderness, dysesthesia, pain, agitation, bradykinesia, opisthotonus, muscle fibrillation, action tremor, chronic pain, sciatica, hyperalgesia, asterixis, astasia, cheyne-stokes respiration, hoarseness, vertigo/dizziness, equilibration disorder, sleeplessness, muscular fasciculation, symptoms, muscle rigidity, muscle spasticity, spasm, cerebellar ataxia, numbness, numbness localized, agitation mental, numb mouth, clouded consciousness, meningism, reflex, abnormal, spasmodic torticollis, dizziness, akathisia, neuralgia, adiadochokinesis, decreased tendon reflex, musculoskeletal symptom, circumoral paresthesia, pathological conditions, signs and symptoms, asynergia, dyskinesia neonatal, staggering gait, non-epileptic convulsion, absence attacks, lid retraction, micropsia, leg cramps, lassitude, spasm oropharyngeal, aphonia, flaccid muscle tone, flaccid paralysis, burning sensation, hypalgesia, lightheadedness, muscular stiffness, muscular incoordination, fine tremor, coarse tremor, epileptic aura, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, bulging fontanelle, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, limb, tremor, muscle, nerve tremors, tremor, neonatal, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, tonic seizures, extreme exhaustion, rigor - temperature-associated observation, burning mucosal, paresthesia mouth, eyes rolling, electric shock sensation, jaw stiffness, muzzy headed, motor restlessness, myotonus (finding), reaction to spinal or lumbar puncture, headache fullness

MGI Mouse Phenotypes related to Nervous System Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 CCR6 CSF2 CXCR3 IFNG IL1B IL6
2 hematopoietic system MP:0005397 10.03 ANKRD11 CCR6 CSF2 CXCR3 IFNG IL1B
3 immune system MP:0005387 9.93 ANKRD11 CCR6 CSF2 CXCR3 IFNG IL1B
4 integument MP:0010771 9.61 CSF2 IFNG IL1B IL6 MMP9 NOS2
5 neoplasm MP:0002006 9.28 CSF2 CXCR3 IFNG IL1B IL6 MMP9

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 532)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Etomidate Approved Phase 4 33125-97-2 36339 667484
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
Memantine Approved, Investigational Phase 4 19982-08-2 4054
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
Vigabatrin Approved Phase 4 68506-86-5, 60643-86-9 5665
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
Ziconotide Approved Phase 4 107452-89-1 447451
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
Acetaminophen Approved Phase 4 103-90-2 1983
Nevirapine Approved Phase 4 129618-40-2 4463
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
Zidovudine Approved Phase 4 30516-87-1 35370
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
Norepinephrine Approved Phase 4 51-41-2 439260
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Histamine Approved, Investigational Phase 4 51-45-6 774
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
Lithium carbonate Approved Phase 4 554-13-2
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
Tapentadol Approved Phase 4 175591-23-8 9838022
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
Choline Approved, Nutraceutical Phase 4 62-49-7 305
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
Cobalamin Experimental Phase 4 13408-78-1 6857388
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
Cortisone Experimental Phase 4 53-06-5 222786
44 Excitatory Amino Acid Antagonists Phase 4
45 Antiparkinson Agents Phase 4
46 Angiotensin-Converting Enzyme Inhibitors Phase 4
47 Soy Bean Phase 4
48 Vitamin B 12 Phase 4
49 Vitamin B12 Phase 4
50 Alpha-lipoic Acid Phase 4

Interventional clinical trials:

(show top 50) (show all 1360)
# Name Status NCT ID Phase Drugs
1 Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial Unknown status NCT01319643 Phase 4 Oxygen
2 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial Unknown status NCT00123136 Phase 4
3 Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
4 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
5 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
6 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
7 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
8 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
9 Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
10 Effect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease: Changes in Biomarkers of Oxidative Stress, Profiles of Plasma Amino Acids and Their Derivatives and Brain Function Completed NCT01662414 Phase 4
11 An Open Label Extension Safety Trial of Pregabalin (CI-1008) in Subjects With Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
12 A 14-Week, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study To Evaluate The Safety And Efficacy Of Pregabalin (150mg-600mg/Day) Using A Flexible Optimal Dose Schedule In Patients With Painful Diabetic Peripheral Neuropathy (DPN). Completed NCT00156078 Phase 4 pregabalin
13 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
14 Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients After Intracranial Surgery (Prophylactic Analgesia and Sedation Trial, PASTrial) Completed NCT01445639 Phase 4 Dexmedetomidine;Normal saline
15 A 13 Week, Double-Blind, Placebo-Controlled Phase 4 Trial of Pregabalin (CI-1008, 600 mg/Day) for Relief of Pain in Subjects With Painful Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
16 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy by Comparing the Change of HRV Index & ANS Function:A 6month Multicenter, Randomized, Open Label Clinical Trial CANON Study Completed NCT02056366 Phase 4 α-lipoic acid
17 A Prospective, Open-label Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Completed NCT01278173 Phase 4 Sabril
18 Comparison of the Analgesic Effect of the Local Anesthetics Ropicacaine, Levobupivacaine, and Levobupivacaine + Epinephrin Via Interscalene Nerve Block in Patients Undergoing Shoulder Arthroscopy Under General Anesthesia Completed NCT02691442 Phase 4 Ropivacaine 0.75%;Levobupivacaine 0.5%;Levobupivacaine 0.5% + epinephrin 1/200000
19 A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
20 A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
21 An Open-label, Randomized, Multi-center Clinical Trial to Evaluate the Safety and Efficacy in Peripheral Neuropathies Patients Treated With Mecobalamin Injection Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
22 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
23 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
24 Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study Completed NCT01373983 Phase 4 Ziconotide
25 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
26 Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China Completed NCT01340950 Phase 4 zidovudine-lamivudine-nevirapine;tenofovir-lamivudine-efavirenz
27 A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
28 A Randomized, Double-Blind, Placebo-Controlled, Single Center Study Designed to Assess the Effects of Pregabalin on Change in Patients With Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
29 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
30 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
31 High-dose Vitamin D Supplementation Reduces Inflammation and Improves Microcirculation in Patients With Diabetic Peripheral Neuropathy Completed NCT04377399 Phase 4 Vitamin D
32 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
33 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment Completed NCT01675531 Phase 4 Targin
34 Comparison of the Effectiveness and Safety Between Tramadol 37.5 Mg/Acetaminophen 325mg And Gabapentin for The Treatment of Painful Diabetic Neuropathy: Multicenter, Randomized, Open Comparative Study Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
35 Study of Memantine to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Monocentric Trial Completed NCT01108029 Phase 4 memantine;placebo
36 Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy: A Randomized, Double Blind, Placebo Controlled, Multi Center Trial Completed NCT02923388 Phase 4 Injection Mecobalamin,;Tablet Pyridoxine hydrochloride;Intravenous normal saline 1 ml;Placebo pill
37 Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentric Trial Completed NCT00914095 Phase 4 methylphenidate;placebo
38 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
39 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
40 Detection of Silent Atrial Fibrillation aFter Ischemic StrOke (SAFFO) Guided by Implantable Loop Recorder. Multicentre Italian Trial Based on Stroke Unit Network With Paired Cardio-Arrhythmology Units (Italian Neurocardiology Unit Network) Recruiting NCT02684825 Phase 4
41 Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients: CODEX Trial Recruiting NCT04289142 Phase 4 Dexmedetomidine Hydrochloride Group
42 Multi-dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics Recruiting NCT03219008 Phase 4 Fluoxetine;fluoxetine + Amfebutamone;Fluvoxamine;Lithium+fluvoxamine;Mirtazapine/SNRIs;mirtazapine + SNRIs
43 Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM) Recruiting NCT04246619 Phase 4 Pregabalin;Duloxetine
44 Dexmedetomidine for Prevention of Postoperative Delirium in Patients After Intracranial Operation for Brain Tumor: a Multicenter Randomized Controlled Trial Not yet recruiting NCT04399343 Phase 4 Dexmedetomidine;Normal saline
45 The Potential Effect of Omega3 Supplement in Fish Oil on Infarced Areas in the Brain and Improvement of Neurological Functions fo Ischemic Stroke Patients Not yet recruiting NCT04386525 Phase 4
46 A Double-blind, Placebo-controlled, Cross-over Study of Ranolazine in Patients With Coronary Artery Disease for the Treatment of Painful Polyneuropathy Terminated NCT00832572 Phase 4 Ranolazine;Placebo
47 Phase 4 Study of Tapentadol vs Oxycodone in Neuropathic Pain Terminated NCT01458015 Phase 4 tapentadol, oxycodone
48 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
49 A Randomized, Double-Blind, Placebo-Controlled Trial Of The Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy Symptoms In Subjects With Advanced Colorectal Cancer Terminated NCT00380874 Phase 4 Pregabalin;Placebo
50 Pilot Study of L-Carnitine Supplementation in the Prevention of Chemotherapy-induced Peripheral Neuropathy in Women With Metastatic Breast Cancer Terminated NCT00754767 Phase 4 L-carnitine L-tartrate

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Anatomical Context for Nervous System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Disease:

Central Nervous System, Peripheral Nervous System

MalaCards organs/tissues related to Nervous System Disease:

Brain, Breast, Spinal Cord, Testes, Bone, T Cells, Heart

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 2323)
# Title Authors PMID Year
Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis. 61
32371533 2020
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. 61
32388458 2020
A comparison study of inhomogeneous magnetization transfer (ihMT) and magnetization transfer (MT) in multiple sclerosis based on whole brain acquisition at 3.0 T. 61
32224092 2020
Fingolimod (FTY720) improves postoperative cognitive dysfunction in mice subjected to D-galactose-induced aging. 61
31960817 2020
Research progress in use of traditional Chinese medicine for treatment of spinal cord injury. 61
32335299 2020
A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study. 61
32009149 2020
Intranasal delivery of topiramate nanoemulsion: Pharmacodynamic, pharmacokinetic and brain uptake studies. 61
32502686 2020
Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report. 61
31887772 2020
Identification of potential natural neuroprotective molecules for Parkinson's disease by using chemoinformatics and molecular docking. 61
32028110 2020
What are the latest clinical findings regarding the association of neurotoxic brain antibodies found in the cerebrospinal fluid in patients with autoimmune disorders? 61
32251024 2020
Selenium-deficient diet induces necroptosis in the pig brain by activating TNFR1 via mir-29a-3p. 61
32568328 2020
Cranial Base Manifestations of Granulomatosis with Polyangiitis. 61
32178578 2020
A Literature Review of Racial Disparities in Overall Survival of Black Children With Acute Lymphoblastic Leukemia Compared With White Children With Acute Lymphoblastic Leukemia. 61
32089043 2020
The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes. 61
32384786 2020
Blood-brain barrier dysfunction: the undervalued frontier of hypertension. 61
32424144 2020
Neurological Etiologies and Pathophysiology of Cyclic Vomiting Syndrome. 61
32107138 2020
A study of serum cortisol levels in acute head injury patients. 61
32469329 2020
miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury. 61
31885334 2020
Effect of AFM Nanoindentation Loading Rate on the Characterization of Mechanical Properties of Vascular Endothelial Cell. 61
32486388 2020
Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons. 61
32476056 2020
Human-Centered Design Strategies for Device Selection in mHealth Programs: Development of a Novel Framework and Case Study. 61
32379055 2020
Effect of Osimertinib and Bevacizumab on Progression-Free Survival for Patients With Metastatic EGFR-Mutant Lung Cancers: A Phase 1/2 Single-Group Open-Label Trial. 61
32463456 2020
MicroRNAs and nervous system diseases: network insights and computational challenges. 61
30953059 2020
A deep learning approach for prediction of Parkinson's disease progression. 61
32477610 2020
Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/β-catenin signaling pathway inhibition. 61
31960520 2020
Measuring Motor Fatigability in the Upper Limbs in Individuals With Neurologic Disorders: A Systematic Review. 61
31891710 2020
Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson's disease. 61
32035284 2020
Epidemiological evaluation and survival of children with acute myeloid leukemia. 61
32325011 2020
Gait Rhythm Dynamics for Neuro-Degenerative Disease Classification via Persistence Landscape- Based Topological Representation. 61
32260065 2020
Whole genome sequencing for mutation discovery in a single case of lysosomal storage disease (MPS type 1) in the dog. 61
32300136 2020
Parental Refusal to Lumbar Puncture: Effects on Treatment, Hospital Stay and Leave Against Medical Advice. 61
32461854 2020
Functional outcomes of spasticity-reducing surgery and rehabilitation at 1-year follow-up in 30 patients. 61
32338191 2020
Olig2 positive cells derived from hair follicle neural crest stem cells in rats. 61
32088378 2020
High Rate of Imipenem Non-Susceptibility among Clinical Nocardia spp. Isolated from Lung Transplant Recipients. 61
32465092 2020
Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. 61
31638080 2020
Prevalence and risk factors of postoperative delirium after spinal surgery: a meta-analysis. 61
32272939 2020
Eruptive neurofibromas in pregnancy. 61
32499474 2020
Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway. 61
32271159 2020
Restless Legs Syndrome in Patients with Behçet's Disease and Multiple Sclerosis: Prevalence, Associated Conditions and Clinical Features. 61
32110142 2020
Superoxide dismutase 1 in health and disease: How a front-line antioxidant becomes neurotoxic. 61
32144830 2020
Anti-CD20 Monoclonal Antibodies for Relapsing and Progressive Multiple Sclerosis. 61
31994023 2020
Treatment and new progress of neonatal hypoxic-ischemic brain damage. 61
32167570 2020
Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes. 61
32139775 2020
Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy? 61
32033258 2020
Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium. 61
30891696 2020
Development of an immunochromatographic device to detect antibodies for rapid diagnosis of human angiostrongyliasis. 61
31690362 2020
A Case of Infratentorial Meningioma Causing Spontaneous Downbeat Nystagmus: Case Report and Review of the Literature. 61
31790839 2020
Inflammatory Monocytes and Neutrophils Regulate Streptococcus suis-Induced Systemic Inflammation and Disease but Are Not Critical for the Development of Central Nervous System Disease in a Mouse Model of Infection. 61
31818962 2020
Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. 61
31904232 2020
The Glucagon-Like Peptide-1 Analogue Liraglutide Reduces Seizures Susceptibility, Cognition Dysfunction and Neuronal Apoptosis in a Mouse Model of Dravet Syndrome. 61
32184723 2020

Variations for Nervous System Disease

ClinVar genetic disease variations for Nervous System Disease:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ANKRD11 NM_013275.6(ANKRD11):c.3309dup (p.Asp1104fs)duplication Pathogenic 812782 16:89349640-89349641 16:89283232-89283233
2 46;X;t(Y;3)(p11.2;p12.3)dnTranslocation Likely pathogenic 267818
3 46;XY;t(1;3)(q32.3;q21.1)Translocation Uncertain significance 267980

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.73 TNF TBK1 NOS2 IL6 IL1B
Show member pathways
Show member pathways
8 12.4 TNF TBK1 IL1B CSF2
Show member pathways
12.34 TNF IL6 CXCR3 CCR6
Show member pathways
Show member pathways
12 12.28 PROM1 MMP9 IL6 CSF2
Show member pathways
14 12.25 TNF TBK1 IL6 IL1B
15 12.24 TNF NOS2 IL6 IL1B IFNG
Show member pathways
12.21 TNF IL1B IFNG H2AC18
17 12.2 TNF NOS2 MMP9 IL6 IFNG
Show member pathways
Show member pathways
20 12.11 TNF MMP9 IL1B IFNG
21 12.03 TNF TBK1 IL6 IL1B
23 11.98 TNF NOS2 MMP9 IL6 IL1B
24 11.96 TNF MMP9 IL6 IL1B CSF2
Show member pathways
26 11.91 TNF IL6 IL1B CSF2
27 11.88 TNF NOS2 MMP9 IL6 IL1B IFNG
28 11.82 TNF IL6 IL1B IFNG CSF2
29 11.81 IL6 IFNG CSF2
30 11.78 TNF NOS2 IL6 IL1B
Show member pathways
33 11.67 TNF IL6 IL1B IFNG CSF2
34 11.64 TNF NOS2 IL6 IL1B IFNG CSF2
35 11.62 TNF IL6 IL1B
36 11.61 NOS2 IL6 IFNG
37 11.57 TNF IL6 IFNG
38 11.57 TNF IL6 IL1B IFNG
39 11.57 TNF MMP9 IL6 IL1B CSF2
40 11.55 TNF IL6 IL1B CSF2
41 11.54 IL6 IL1B CSF2
42 11.53 TNF IL1B IFNG
43 11.53 TNF MMP9 IL6
44 11.53 TNF NOS2 IL1B IFNG
45 11.49 TNF IL6 IL1B IFNG
46 11.4 NOS2 IL1B IFNG
Show member pathways
48 11.37 TNF IL6 IL1B
49 11.36 TNF IL6 IL1B IFNG
50 11.31 TNF IL6 IL1B

GO Terms for Nervous System Disease

Cellular components related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TNF SERPINA3 PROM1 MMP9 MIR199A1 IL6

Biological processes related to Nervous System Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 TNF IL6 IL1B IFNG CSF2
2 positive regulation of protein phosphorylation GO:0001934 9.93 TNF MMP9 IL1B IFNG
3 cellular response to lipopolysaccharide GO:0071222 9.83 TNF NOS2 IL6 IL1B CSF2
4 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL6 IL1B
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 TNF IL6 IFNG CSF2
6 positive regulation of phagocytosis GO:0050766 9.78 TNF IL1B IFNG
7 regulation of insulin secretion GO:0050796 9.78 TNF NOS2 IL1B IFNG
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF IL1B IFNG
9 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF IL1B IFNG
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.75 TNF IL1B CSF2
11 negative regulation of neurogenesis GO:0050768 9.74 TNF IL6 IL1B
12 cytokine-mediated signaling pathway GO:0019221 9.73 TNF NOS2 MMP9 IL6 IL1B CSF2
13 macrophage differentiation GO:0030225 9.71 MMP9 IFNG CSF2
14 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6 IL1B
15 immune response GO:0006955 9.7 TNF IL6 IL1B IFNG CXCR3 CSF2
16 astrocyte activation GO:0048143 9.69 TNF IL1B IFNG
17 humoral immune response GO:0006959 9.67 TNF IL6 IFNG CCR6
18 regulation of neuroinflammatory response GO:0150077 9.66 MMP9 IL6
19 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
20 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
21 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.64 TNF IFNG
22 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 TNF IL1B IFNG
24 positive regulation of killing of cells of other organism GO:0051712 9.62 NOS2 IFNG
25 positive regulation of interleukin-23 production GO:0032747 9.62 IFNG CSF2
26 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
27 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
28 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IL1B IFNG
29 positive regulation of vitamin D biosynthetic process GO:0060557 9.56 TNF IFNG
30 positive regulation of nitrogen compound metabolic process GO:0051173 9.55 TNF IFNG
31 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
32 inflammatory response GO:0006954 9.5 TNF TBK1 SERPINA3 NOS2 IL6 IL1B
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IFNG CSF2

Sources for Nervous System Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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