MCID: NRV007
MIFTS: 66

Nervous System Disease

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 15 17
Abnormality of the Nervous System 6
Nervous System Diseases 43
Nervous System Disorder 71

Classifications:



External Ids:

Disease Ontology 12 DOID:863
ICD9CM 34 349.9
MeSH 43 D009422
NCIt 49 C26835
UMLS 71 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to central nervous system disease and peripheral nervous system disease, and has symptoms including seizures, ataxia and tremor. An important gene associated with Nervous System Disease is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Ketamine and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include central nervous system, peripheral nervous system and brain, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Infectious Disease of the Nervous System

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1206)
# Related Disease Score Top Affiliating Genes
1 central nervous system disease 35.9 TBK1 SERPINA3 PROM1 NOS2 MOG MMP9
2 peripheral nervous system disease 35.6 TNF SERPINA3 PMP22 MOG IL6 IL1B
3 multiple sclerosis 33.6 TNF NOS2 MOG MMP9 IL6 IL1B
4 meningitis 33.6 TNF MMP9 IL6 IL1B IFNG CSF2
5 meningoencephalitis 33.4 TNF IL6 CCR6
6 toxic encephalopathy 33.0 TNF SERPINA3 IL6 IL1B H2AC18
7 guillain-barre syndrome 32.3 TNF PMP22 MOG
8 acute disseminated encephalomyelitis 32.2 MOG IL1B CCR6
9 neuromuscular disease 32.1 TNF SERPINA3 PMP22 IL6 H2AC18 GJB1
10 encephalitis 32.1 TNF NOS2 MOG IL6 IL1B
11 systemic lupus erythematosus 31.9 TNF MMP9 IL6 IL1B IFNG H2AC18
12 demyelinating disease 31.9 TNF SERPINA3 PMP22 MOG MMP9 IL6
13 autoimmune disease 31.9 TNF MOG MMP9 IL6 IL1B IFNG
14 acquired immunodeficiency syndrome 31.7 TNF NOS2 IL6 IL1B IFNG CSF2
15 neuritis 31.7 TNF PMP22 MOG MMP9 IL6 IL1B
16 measles 31.7 TNF IL6 IL1B IFNG
17 polyneuropathy 31.7 TNF PMP22 IL6 IL1B GJB1
18 immune deficiency disease 31.7 TNF IL6 IFNG H2AC18 CSF2 CCR6
19 bacterial meningitis 31.7 TNF MMP9 IL6 IL1B IFNG CSF2
20 neuromuscular junction disease 31.6 SERPINA3 H2AC18 CCR6
21 histiocytosis 31.6 TNF SERPINA3 CSF2 CCR6
22 viral encephalitis 31.6 TNF MOG IL6 IL1B CCR6
23 leukemia, acute myeloid 31.6 TNF SERPINA3 PROM1 IL6 H2AC18 CSF2
24 stomatitis 31.6 TNF IL6 IL1B IFNG CSF2
25 myelitis 31.6 TNF MOG MMP9 IL6 CCR6
26 toxoplasmosis 31.6 TNF NOS2 IL6 IL1B IFNG
27 subacute sclerosing panencephalitis 31.5 TNF MOG IL6 IFNG
28 aseptic meningitis 31.5 TNF IL1B IFNG
29 optic neuritis 31.5 TNF MOG IL1B CXCR3
30 spinal cord injury 31.5 TNF NOS2 MMP9 IL6
31 chickenpox 31.4 TNF IL6 IFNG CCR6
32 sarcoidosis 1 31.4 TNF SERPINA3 IL1B IFNG CXCR3 CCR6
33 optic nerve disease 31.4 TNF SERPINA3 MOG IL6 CRYAA CCR6
34 psoriatic arthritis 31.4 TNF IL6 IL1B IFNG CCR6
35 migraine with or without aura 1 31.3 TNF IL6 IL1B H2AC18
36 relapsing-remitting multiple sclerosis 31.3 TNF MOG MMP9 IL6 IL1B IFNG
37 gliosarcoma 31.3 SERPINA3 PROM1 MMP9 IFNG CSF2
38 trypanosomiasis 31.3 TNF NOS2 IL6 IL1B IFNG CXCR3
39 viral meningitis 31.3 IL6 IFNG CXCR3
40 myeloma, multiple 31.3 TNF MMP9 IL6 IFNG H2AC18 CSF2
41 vascular disease 31.3 TNF NOS2 MMP9 IL6 IFNG
42 toxic shock syndrome 31.3 TNF NOS2 IL6 IL1B IFNG
43 spinal cord disease 31.2 TNF MOG IL6 H2AC18 CCR6
44 vascular dementia 31.2 TNF SERPINA3 MMP9 IL6 IL1B
45 polyradiculopathy 31.2 TNF PMP22 IL6 IL1B
46 bacterial sepsis 31.2 TNF NOS2 IL6 CCR6
47 allergic hypersensitivity disease 31.2 TNF IFNG H2AC18 CSF2 CCR6
48 crohn's disease 31.1 TNF IL6 IL1B IFNG CCR6
49 lyme disease 31.1 TNF MMP9 IL6 IL1B
50 eye disease 31.1 TNF SERPINA3 MMP9 IL6 IL1B IFNG

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:


seizures, ataxia, tremor, myoclonus, gait ataxia, back pain, ophthalmoplegia, vertigo, pain, agitation, headache, clumsiness, involuntary movements, dysdiadochokinesis, action tremor, bradykinesia, hemiplegia, torticollis, muscle fibrillation, syncope, hyperesthesia, hemiparesis, athetosis, opisthotonus, asterixis, cogwheel rigidity, dysesthesia, scalp tenderness, hyperalgesia, chronic pain, sciatica, astasia, cheyne-stokes respiration, hoarseness, vertigo/dizziness, equilibration disorder, sleeplessness, muscular fasciculation, symptoms, muscle rigidity, muscle spasticity, spasm, cerebellar ataxia, numbness, numbness localized, agitation mental, numb mouth, clouded consciousness, meningism, reflex, abnormal, spasmodic torticollis, dizziness, akathisia, neuralgia, adiadochokinesis, decreased tendon reflex, musculoskeletal symptom, circumoral paresthesia, pathological conditions, signs and symptoms, asynergia, dyskinesia neonatal, staggering gait, non-epileptic convulsion, absence attacks, lid retraction, micropsia, leg cramps, lassitude, spasm oropharyngeal, aphonia, flaccid muscle tone, flaccid paralysis, burning sensation, hypalgesia, lightheadedness, muscular stiffness, muscular incoordination, fine tremor, coarse tremor, epileptic aura, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, bulging fontanelle, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, limb, tremor, muscle, nerve tremors, tremor, neonatal, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, tonic seizures, extreme exhaustion, rigor - temperature-associated observation, burning mucosal, paresthesia mouth, eyes rolling, electric shock sensation, jaw stiffness, muzzy headed, motor restlessness, myotonus (finding), reaction to spinal or lumbar puncture, headache fullness

MGI Mouse Phenotypes related to Nervous System Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CCR6 CSF2 CXCR3 IFNG IL1B IL6
2 hematopoietic system MP:0005397 10.1 CCR6 CSF2 CXCR3 GJB1 IFNG IL1B
3 immune system MP:0005387 10.03 CCR6 CSF2 CXCR3 GJB1 IFNG IL1B
4 neoplasm MP:0002006 9.81 CSF2 CXCR3 IFNG IL1B IL6 MMP9
5 nervous system MP:0003631 9.73 CCR6 CSF2 GJB1 IFNG IL1B IL6
6 vision/eye MP:0005391 9.28 GJB1 IFNG IL6 MMP9 MOG NOS2

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 561)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Etomidate Approved Phase 4 33125-97-2 667484 36339
3
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Memantine Approved, Investigational Phase 4 19982-08-2 4054
7
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
8
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
9
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
10
Vigabatrin Approved Phase 4 60643-86-9, 68506-86-5 5665
11
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
12
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
13
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
14
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
15
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
16
Acetaminophen Approved Phase 4 103-90-2 1983
17
Ziconotide Approved Phase 4 107452-89-1 447451
18
Zidovudine Approved Phase 4 30516-87-1 35370
19
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
20
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
21
Nevirapine Approved Phase 4 129618-40-2 4463
22
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
23
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
24
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
25
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
26
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
27
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
28
Histamine Approved, Investigational Phase 4 51-45-6 774
29
Lithium carbonate Approved Phase 4 554-13-2
30
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
31
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
32
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
33
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
34
Tapentadol Approved Phase 4 175591-23-8 9838022
35
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
36
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
37
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
38
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
39
Choline Approved, Nutraceutical Phase 4 62-49-7 305
40
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
41
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
42
Cobalamin Experimental Phase 4 13408-78-1 6857388
43
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
44
Cortisone Experimental Phase 4 53-06-5 222786
45 Antineoplastic Agents, Hormonal Phase 4
46 Anesthetics, Intravenous Phase 4
47 Anesthetics, Dissociative Phase 4
48 Dopamine Agents Phase 4
49 Nootropic Agents Phase 4
50 Excitatory Amino Acid Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1262)
# Name Status NCT ID Phase Drugs
1 Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial Unknown status NCT01319643 Phase 4 Oxygen
2 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial Unknown status NCT00123136 Phase 4
3 Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
4 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
5 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
6 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
7 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
8 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
9 Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
10 Effect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease: Changes in Biomarkers of Oxidative Stress, Profiles of Plasma Amino Acids and Their Derivatives and Brain Function Completed NCT01662414 Phase 4
11 An Open Label Extension Safety Trial of Pregabalin (CI-1008) in Subjects With Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
12 A 14-Week, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study To Evaluate The Safety And Efficacy Of Pregabalin (150mg-600mg/Day) Using A Flexible Optimal Dose Schedule In Patients With Painful Diabetic Peripheral Neuropathy (DPN). Completed NCT00156078 Phase 4 pregabalin
13 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
14 Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients After Intracranial Surgery (Prophylactic Analgesia and Sedation Trial, PASTrial) Completed NCT01445639 Phase 4 Dexmedetomidine;Normal saline
15 A 13 Week, Double-Blind, Placebo-Controlled Phase 4 Trial of Pregabalin (CI-1008, 600 mg/Day) for Relief of Pain in Subjects With Painful Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
16 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy by Comparing the Change of HRV Index & ANS Function:A 6month Multicenter, Randomized, Open Label Clinical Trial CANON Study Completed NCT02056366 Phase 4 α-lipoic acid
17 A Prospective, Open-label Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Completed NCT01278173 Phase 4 Sabril
18 Comparison of the Analgesic Effect of the Local Anesthetics Ropicacaine, Levobupivacaine, and Levobupivacaine + Epinephrin Via Interscalene Nerve Block in Patients Undergoing Shoulder Arthroscopy Under General Anesthesia Completed NCT02691442 Phase 4 Ropivacaine 0.75%;Levobupivacaine 0.5%;Levobupivacaine 0.5% + epinephrin 1/200000
19 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
20 A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
21 A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
22 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
23 An Open-label, Randomized, Multi-center Clinical Trial to Evaluate the Safety and Efficacy in Peripheral Neuropathies Patients Treated With Mecobalamin Injection Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
24 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
25 Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study Completed NCT01373983 Phase 4 Ziconotide
26 Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China Completed NCT01340950 Phase 4 zidovudine-lamivudine-nevirapine;tenofovir-lamivudine-efavirenz
27 A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
28 A Randomized, Double-Blind, Placebo-Controlled, Single Center Study Designed to Assess the Effects of Pregabalin on Change in Patients With Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
29 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
30 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
31 Comparison of the Effectiveness and Safety Between Tramadol 37.5 Mg/Acetaminophen 325mg And Gabapentin for The Treatment of Painful Diabetic Neuropathy: Multicenter, Randomized, Open Comparative Study Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
32 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
33 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment Completed NCT01675531 Phase 4 Targin
34 Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy: A Randomized, Double Blind, Placebo Controlled, Multi Center Trial Completed NCT02923388 Phase 4 Injection Mecobalamin,;Tablet Pyridoxine hydrochloride;Intravenous normal saline 1 ml;Placebo pill
35 Study of Memantine to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Monocentric Trial Completed NCT01108029 Phase 4 memantine;placebo
36 Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentric Trial Completed NCT00914095 Phase 4 methylphenidate;placebo
37 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
38 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
39 Detection of Silent Atrial Fibrillation aFter Ischemic StrOke (SAFFO) Guided by Implantable Loop Recorder. Multicentre Italian Trial Based on Stroke Unit Network With Paired Cardio-Arrhythmology Units (Italian Neurocardiology Unit Network) Recruiting NCT02684825 Phase 4
40 Multi-dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics Recruiting NCT03219008 Phase 4 Fluoxetine;fluoxetine + Amfebutamone;Fluvoxamine;Lithium+fluvoxamine;Mirtazapine/SNRIs;mirtazapine + SNRIs
41 A Double-blind, Placebo-controlled, Cross-over Study of Ranolazine in Patients With Coronary Artery Disease for the Treatment of Painful Polyneuropathy Terminated NCT00832572 Phase 4 Ranolazine;Placebo
42 Phase 4 Study of Tapentadol vs Oxycodone in Neuropathic Pain Terminated NCT01458015 Phase 4 tapentadol, oxycodone
43 A Randomized, Double-Blind, Placebo-Controlled Trial Of The Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy Symptoms In Subjects With Advanced Colorectal Cancer Terminated NCT00380874 Phase 4 Pregabalin;Placebo
44 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
45 Precision Spinal Cord Stimulation for Painful Diabetic Neuropathy Terminated NCT00487981 Phase 4
46 Pilot Study of L-Carnitine Supplementation in the Prevention of Chemotherapy-induced Peripheral Neuropathy in Women With Metastatic Breast Cancer Terminated NCT00754767 Phase 4 L-carnitine L-tartrate
47 Intelligent Activity-based Client-centred Training Unknown status NCT02982811 Phase 3
48 Use of Topical Lidocaine (Lidoderm 5% Patch) to Reduce Pain in Patients With Diabetic Neuropathy: Does the Density and Subtype of Sodium Channels Affect Response? Unknown status NCT01086150 Phase 2, Phase 3
49 Phase 3 Study to Evaluate Bortezomib Induced Peripheral Neuropathy of Multiple Myeloma (MM) Patients. Unknown status NCT00872352 Phase 3
50 Study of Topical Preparation of Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy Unknown status NCT01125215 Phase 2, Phase 3 0.75% capsaicin nanoparticle cream;Placebo

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Anatomical Context for Nervous System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Disease:

19
Central Nervous System, Peripheral Nervous System

MalaCards organs/tissues related to Nervous System Disease:

40
Brain, Breast, Spinal Cord, Testes, Bone, Heart, T Cells

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 2258)
# Title Authors PMID Year
1
Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. 61
31638080 2020
2
Microvascular pericytes in brain-associated vascular disease. 61
31743876 2020
3
GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. 61
30513217 2019
4
Inflammatory monocytes and neutrophils regulate Streptococcus suis-induced systemic inflammation and disease but are not critical for the development of central nervous system disease in a mouse model of infection. 61
31818962 2019
5
Neuron specific enolase as a marker of seizure related neuronal injury. 61
31404559 2019
6
Expert insights: The potential role of the gut microbiome-bile acid-brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy. 61
31808182 2019
7
Meta-transcriptomic identification of hepatitis B virus in cerebrospinal fluid in patients with central nervous system disease. 61
31451314 2019
8
Vaccine Oka Varicella Meningitis in Two Adolescents. 61
31776194 2019
9
The GTF2I rs117026326 polymorphism is associated with neuromyelitis optica spectrum disorder but not with multiple sclerosis in a Northern Han Chinese population. 61
31520790 2019
10
MiR-20b-5p relieves neuropathic pain by targeting Akt3 in a chronic constriction injury rat model. 61
31381191 2019
11
Long non-coding RNA GAS5 promotes PC12 cells differentiation into Tuj1-positive neuron-like cells and induces cell cycle arrest. 61
31397350 2019
12
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease. 61
30537919 2019
13
Utility of Surface and Blood Polymerase Chain Reaction Assays in Identifying Infants With Neonatal Herpes Simplex Virus Infection. 61
31626049 2019
14
Results of an epidemiological study on a central nervous system disease of unknown cause that occurred in the Minamata region. 61
31685726 2019
15
The Spatial and Temporal Characters of Demyelination and Remyelination in the Cuprizone Animal Model. 61
31251832 2019
16
PARP-1 mediated cell death is directly activated by ZIKV infection. 61
31539774 2019
17
Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease. 61
31625835 2019
18
A case of infratentorial meningioma causing spontaneous downbeat nystagmus. Case report and review of literatures. 61
31790839 2019
19
Development of an immunochromatographic device to detect antibodies for rapid diagnosis of human angiostrongyliasis. 61
31690362 2019
20
Autophagy in Myelinating Glia. 61
31744863 2019
21
[A review on muscle-specific microRNAs as the biomarker for Duchenne muscular dystrophy]. 61
31753100 2019
22
Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies. 61
31367942 2019
23
The assessment of lenticulostriate arteries originating from middle cerebral artery using ultra high-field magnetic resonance time-of-flight angiography. 61
31331750 2019
24
Impact of Travel Distance on Radiation Treatment Modality for Central Nervous System Disease. 61
31831978 2019
25
[β Amyloid Hypothesis in Alzheimer's Disease:Pathogenesis,Prevention,and Management]. 61
31699204 2019
26
Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis. 61
31008556 2019
27
Large animal models contribute to the development of therapies for central and peripheral nervous system dysfunction in patients with lysosomal storage diseases. 61
31384936 2019
28
Central nervous system disease in childhood acute lymphoblastic leukemia. 61
26990196 2019
29
Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease. 61
31172405 2019
30
Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis. 61
31279154 2019
31
Electroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain. 61
31807253 2019
32
Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines. 61
31357132 2019
33
Glial Fibrillary Acidic Protein (GFAP) Autoimmunity in the Setting of Seropositive Rheumatoid Arthritis Treated With Etanercept. 61
31478999 2019
34
A Confocal Reflection Super-Resolution Technique to Image Golgi-Cox Stained Neurons. 61
31237354 2019
35
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice. 61
31221479 2019
36
Viral Sequences Detection by High-Throughput Sequencing in Cerebrospinal Fluid of Individuals with and without Central Nervous System Disease. 61
31431002 2019
37
Neurotheranostics as personalized medicines. 61
30421721 2019
38
Comparative study of striatum GABA concentrations and magnetic resonance spectroscopic imaging in Parkinson's disease monkeys. 61
31395015 2019
39
Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. 61
31390162 2019
40
Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases. 61
31078693 2019
41
Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-β-SOX9 Signaling Pathway. 61
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42
Challenges in the Daily Living Activities of Patients with Multiple Sclerosis: A Qualitative Content Analysis. 61
31341919 2019
43
Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network. 61
29579224 2019
44
Neurological Manifestations Do not Affect Cumulative Survival in Indian Patients with Antineutrophil Cytoplasmic Antibody Associated Vasculitis. 61
31512630 2019
45
Brentuximab Vedotin and High-dose Methotrexate Administrated Alternately for Refractory Anaplastic Large-cell Lymphoma With Central Nervous System Disease. 61
31274669 2019
46
Rare and unusual case of hepatic and disseminated tuberculosis in an immunocompetent patient. 61
31229981 2019
47
Aquaporin-4 Serostatus and Visual Outcomes in Clinically Isolated Acute Optic Neuritis. 61
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Assessing the anterior visual pathway in optic neuritis: recent experimental and clinical aspects. 61
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49
Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats. 61
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Meningoencephalitis due to Naegleria fowleri in cattle in southern Brazil. 61
31188946 2019

Variations for Nervous System Disease

ClinVar genetic disease variations for Nervous System Disease:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;X;t(Y;3)(p11.2;p12.3)dnTranslocation Likely pathogenic 267818
2 46;XY;t(1;3)(q32.3;q21.1)Translocation Uncertain significance 267980

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.37 TNF NOS2 MMP9 IL6 IL1B IFNG
2
Show member pathways
13.13 TNF TBK1 NOS2 MMP9 IL6 IL1B
3
Show member pathways
12.83 TNF TBK1 IL6 IL1B IFNG
4 12.8 TNF TBK1 IL6 IL1B IFNG
5
Show member pathways
12.77 TNF TBK1 IL6 IL1B IFNG
6
Show member pathways
12.62 TNF IL6 IL1B IFNG CSF2
7
Show member pathways
12.6 TNF NOS2 IL6 IL1B IFNG
8 12.39 TNF TBK1 IL1B CSF2
9
Show member pathways
12.35 TNF SERPINA3 IL6 IL1B IFNG
10
Show member pathways
12.34 TNF IL6 CXCR3 CCR6
11
Show member pathways
12.33 TNF NOS2 IL6 IL1B IFNG
12
Show member pathways
12.28 TNF NOS2 IL1B IFNG
13 12.27 PROM1 MMP9 IL6 CSF2
14 12.26 TNF TBK1 IL6 IL1B
15 12.26 TNF NOS2 IL6 IL1B IFNG
16
Show member pathways
12.24 TNF NOS2 IL6 IL1B
17
Show member pathways
12.23 TNF IL1B IFNG H2AC18
18 12.22 TNF NOS2 MMP9 IL6 IFNG
19
Show member pathways
12.21 TNF NOS2 IL6 IL1B IFNG
20
Show member pathways
12.2 TNF TBK1 MMP9 IL6 IL1B IFNG
21 12.11 TNF MMP9 IL1B IFNG
22
Show member pathways
12.08 TNF IL6 IL1B IFNG
23 12.03 TNF TBK1 IL6 IL1B
24 12.01 TNF IL6 IFNG CSF2
25 12.01 TNF NOS2 MMP9 IL6 IL1B
26 11.99 TNF MMP9 IL6 IL1B CSF2
27
Show member pathways
11.98 TNF MMP9 IL6 IL1B IFNG CSF2
28 11.92 TNF IL6 IL1B CSF2
29 11.92 TNF NOS2 MMP9 IL6 IL1B IFNG
30 11.88 TNF IL6 IL1B IFNG CSF2
31 11.81 IL6 IFNG CSF2
32 11.8 TNF NOS2 IL6 IL1B
33 11.8 NOS2 IL6 IL1B IFNG CSF2
34 11.78 TNF IL1B IFNG CXCR3 CCR6
35
Show member pathways
11.77 TNF IFNG CSF2
36 11.74 TNF NOS2 IL6 IL1B IFNG CSF2
37 11.72 TNF IL6 IL1B IFNG CSF2
38 11.63 TNF IL6 IL1B
39 11.63 TNF MMP9 IL6 IL1B CSF2
40 11.61 NOS2 IL6 IFNG
41 11.59 TNF IL6 IL1B IFNG
42 11.58 TNF IL6 IL1B CSF2
43 11.57 TNF IL6 IFNG
44 11.56 TNF NOS2 IL1B IFNG
45 11.54 IL6 IL1B CSF2
46 11.54 TNF IL1B IFNG
47 11.54 TNF MMP9 IL6
48 11.52 TNF IL6 IL1B IFNG
49 11.41 NOS2 IL1B IFNG
50 11.41 TNF IL6 IL1B IFNG

GO Terms for Nervous System Disease

Biological processes related to Nervous System Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.03 TNF IL6 IL1B IFNG CSF2
2 inflammatory response GO:0006954 10 TNF TBK1 SERPINA3 IL6 IL1B CXCR3
3 positive regulation of protein phosphorylation GO:0001934 9.92 TNF MMP9 IL1B IFNG
4 cellular response to lipopolysaccharide GO:0071222 9.83 TNF NOS2 IL6 IL1B CSF2
5 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL6 IL1B
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 TNF IL6 IFNG CSF2
7 positive regulation of phagocytosis GO:0050766 9.77 TNF IL1B IFNG
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TNF IL1B IFNG
9 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.74 TNF IL1B CSF2
10 negative regulation of neurogenesis GO:0050768 9.73 TNF IL6 IL1B
11 regulation of insulin secretion GO:0050796 9.71 TNF NOS2 IL1B IFNG
12 positive regulation of glial cell proliferation GO:0060252 9.69 TNF IL6 IL1B
13 astrocyte activation GO:0048143 9.67 TNF IL1B IFNG
14 negative regulation of amyloid-beta clearance GO:1900222 9.65 TNF IFNG
15 regulation of neuroinflammatory response GO:0150077 9.64 MMP9 IL6
16 negative regulation of lipid storage GO:0010888 9.64 TNF IL6
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 TNF IL1B IFNG
18 cytokine-mediated signaling pathway GO:0019221 9.63 TNF NOS2 MMP9 IL6 IL1B CSF2
19 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
20 humoral immune response GO:0006959 9.62 TNF IL6 IFNG CCR6
21 positive regulation of killing of cells of other organism GO:0051712 9.61 NOS2 IFNG
22 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG CSF2
23 positive regulation of fever generation GO:0031622 9.6 TNF IL1B
24 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
25 positive regulation of vitamin D biosynthetic process GO:0060557 9.55 TNF IFNG
26 positive regulation of nitrogen compound metabolic process GO:0051173 9.54 TNF IFNG
27 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
28 immune response GO:0006955 9.5 TNF IL6 IL1B IFNG CXCR3 CSF2
29 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TNF IL1B IFNG
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IFNG CSF2

Sources for Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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