MCID: NRV007
MIFTS: 68

Nervous System Disease

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 15 17
Abnormality of the Nervous System 6
Nervous System Diseases 44
Nervous System Disorder 72

Classifications:



External Ids:

Disease Ontology 12 DOID:863
ICD9CM 35 349.9
MeSH 44 D009422
NCIt 50 C26835
UMLS 72 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to central nervous system disease and peripheral nervous system disease, and has symptoms including seizures, ataxia and tremor. An important gene associated with Nervous System Disease is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ketamine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Infectious Disease of the Nervous System

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 985)
# Related Disease Score Top Affiliating Genes
1 central nervous system disease 35.7 TNF TBK1 PROM1 NOS2 MTDH MOG
2 peripheral nervous system disease 35.4 TNF MOG IL6
3 meningitis 33.7 TNF MMP9 IL6 IL1B IFNG
4 multiple sclerosis 33.6 TNF NOS2 MOG MMP9 IL6 IL1B
5 autoimmune disease 32.0 TNF MOG IL6 IL1B IFNG
6 demyelinating disease 32.0 TNF MOG MMP9 IL1B IFNG
7 acquired immunodeficiency syndrome 31.9 TNF IL6 IL1B IFNG CSF2
8 neuritis 31.9 TNF MOG IL1B IFNG
9 aseptic meningitis 31.8 TNF IL1B IFNG
10 hematopoietic stem cell transplantation 31.8 TNF IL6 IFNG
11 bacterial meningitis 31.8 TNF MMP9 IL6 IL1B
12 myelitis 31.8 TNF MOG IL6
13 viral encephalitis 31.8 TNF IL6 IL1B
14 toxoplasmosis 31.7 TNF IL6 IL1B IFNG
15 stomatitis 31.7 TNF IL1B CSF2
16 spinal cord injury 31.7 TNF NOS2 MMP9 IL6
17 sarcoidosis 1 31.6 TNF IL1B IFNG CXCR3 CSF2
18 cerebral palsy 31.5 TNF IL6 IL1B
19 relapsing-remitting multiple sclerosis 31.4 TNF MOG MMP9 IFNG
20 trypanosomiasis 31.4 TNF IL6 IL1B IFNG
21 spinal cord disease 31.4 TNF MOG IL6
22 lyme disease 31.4 TNF MMP9 IL6 IL1B
23 uveitis 31.3 TNF IFNG CXCR3
24 central nervous system vasculitis 31.3 TNF IL6 IL1B IFNG
25 myocarditis 31.3 TNF NOS2 IL6
26 toxic shock syndrome 31.2 TNF IL6 IL1B IFNG
27 chlamydia 31.2 TNF NOS2 IL6 IL1B IFNG
28 transverse myelitis 31.2 TNF MMP9 IL6
29 colitis 31.2 TNF NOS2 IL6 IL1B IFNG
30 bacterial infectious disease 31.2 TNF IL6 IL1B IFNG CSF2
31 cytomegalovirus retinitis 31.2 TNF IFNG CSF2
32 mouth disease 31.2 TNF IL6 IL1B IFNG
33 rasmussen encephalitis 31.2 TNF IL6 IFNG
34 keratoconjunctivitis sicca 31.2 TNF IL6 IL1B
35 ulcerative colitis 31.2 TNF IL6 IL1B IFNG
36 brucellosis 31.1 TNF IL6 IFNG
37 human immunodeficiency virus infectious disease 31.1 TNF IL6 IFNG
38 secondary progressive multiple sclerosis 31.1 MMP9 IFNG CXCR3
39 gastroenteritis 31.1 TNF IL6 IL1B
40 inflammatory bowel disease 31.1 TNF IL6 IL1B IFNG
41 brain edema 31.1 MMP9 IL6 IL1B
42 chronic fatigue syndrome 31.1 TNF IL6 IL1B
43 sleep apnea 31.0 TNF IL6 IL1B
44 vascular disease 31.0 TNF NOS2 MMP9 IL6
45 glucose metabolism disease 31.0 TNF IL6 IL1B
46 autonomic nervous system disease 12.6
47 amyotrophic lateral sclerosis 1 11.6
48 neuromyelitis optica 11.5
49 neuroleptic malignant syndrome 11.5
50 meningoencephalitis 11.3

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:


seizures, ataxia, tremor, myoclonus, gait ataxia, back pain, ophthalmoplegia, vertigo, pain, agitation, headache, clumsiness, involuntary movements, dysdiadochokinesis, action tremor, bradykinesia, hemiplegia, torticollis, muscle fibrillation, syncope, hyperesthesia, hemiparesis, athetosis, chronic pain, opisthotonus, asterixis, cogwheel rigidity, dysesthesia, sciatica, astasia, scalp tenderness, hyperalgesia, cheyne-stokes respiration, hoarseness, vertigo/dizziness, equilibration disorder, sleeplessness, muscular fasciculation, symptoms, muscle rigidity, muscle spasticity, spasm, cerebellar ataxia, numbness, numbness localized, agitation mental, numb mouth, clouded consciousness, meningism, reflex, abnormal, spasmodic torticollis, dizziness, akathisia, neuralgia, adiadochokinesis, decreased tendon reflex, musculoskeletal symptom, circumoral paresthesia, pathological conditions, signs and symptoms, asynergia, dyskinesia neonatal, staggering gait, non-epileptic convulsion, absence attacks, lid retraction, micropsia, leg cramps, lassitude, spasm oropharyngeal, aphonia, flaccid muscle tone, flaccid paralysis, burning sensation, hypalgesia, lightheadedness, muscular stiffness, muscular incoordination, fine tremor, coarse tremor, epileptic aura, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, bulging fontanelle, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, limb, tremor, muscle, nerve tremors, tremor, neonatal, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, tonic seizures, extreme exhaustion, rigor - temperature-associated observation, burning mucosal, paresthesia mouth, eyes rolling, electric shock sensation, jaw stiffness, muzzy headed, motor restlessness, myotonus (finding), reaction to spinal or lumbar puncture, headache fullness

MGI Mouse Phenotypes related to Nervous System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 CCR1 CSF2 CXCR3 IFNG IL1B IL6
2 hematopoietic system MP:0005397 10.25 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
3 homeostasis/metabolism MP:0005376 10.22 CCR1 CCR6 CSF2 CXCR3 GC IFNG
4 cellular MP:0005384 10.2 CCR1 CSF2 CXCR3 IFNG IL6 MMP9
5 immune system MP:0005387 10.18 CCR1 CCR6 CSF2 CXCR3 IFNG IL1B
6 integument MP:0010771 9.97 CSF2 IFNG IL1B IL6 MMP9 MTDH
7 neoplasm MP:0002006 9.85 CSF2 CXCR3 IFNG IL1B IL6 MMP9
8 liver/biliary system MP:0005370 9.8 CCR1 IFNG IL6 MTDH NOS2 TBK1
9 renal/urinary system MP:0005367 9.56 CCR1 CSF2 CXCR3 IFNG IL6 MMP9
10 respiratory system MP:0005388 9.23 CCR1 CSF2 CXCR3 IFNG IL6 MMP9

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 592)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Etomidate Approved Phase 4 33125-97-2 36339 667484
7
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
8
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
9
Norepinephrine Approved Phase 4 51-41-2 439260
10
Memantine Approved, Investigational Phase 4 19982-08-2 4054
11
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
12
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
13
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
14
Vigabatrin Approved Phase 4 60643-86-9, 68506-86-5 5665
15
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
16
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
17
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
18
Acetaminophen Approved Phase 4 103-90-2 1983
19
Ziconotide Approved Phase 4 107452-89-1 447451
20
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
21
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
22
Nevirapine Approved Phase 4 129618-40-2 4463
23
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
24
Zidovudine Approved Phase 4 30516-87-1 35370
25
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
26
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
27
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
28
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
29
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
30
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
31
Histamine Approved, Investigational Phase 4 51-45-6 774
32
Lithium carbonate Approved Phase 4 554-13-2
33
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
34
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
35
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
36
Tapentadol Approved Phase 4 175591-23-8 9838022
37
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
38
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
39
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
40
Choline Approved, Nutraceutical Phase 4 62-49-7 305
41
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
42
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
43
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
44
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
45
Cortisone Experimental Phase 4 53-06-5 222786
46 Hormone Antagonists Phase 4
47 Antiemetics Phase 4
48 Gastrointestinal Agents Phase 4
49 Hormones Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1220)
# Name Status NCT ID Phase Drugs
1 Normal Oxygenation Maintenance in Intensive Care Unit: Randomized Controlled Trial Unknown status NCT01319643 Phase 4 Oxygen
2 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy. Multi-Center, Randomized Placebo Controlled Trial Unknown status NCT00123136 Phase 4
3 Inspiratory Muscle Training in Patients With Autonomic Neuropathic: a Randomized Trial Unknown status NCT00752440 Phase 4
4 Treatment With Gamunex 10% Intravenous Immunoglobulin (IVIg) for Patients With Demyelination and Diabetes Mellitus: A Blinded, Placebo-Controlled Crossover Pilot Study Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
5 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
6 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
7 Banlangen Granules Anti-seasonal Influenza Study: a Randomized, Double Blind, Positive and Placebo Controlled,Clinical Study. Unknown status NCT02232945 Phase 4 placebo of oseltamivir phosphate;oseltamivir phosphate;Banlangen (Radix Isatidis) granules;placebo of Banlangen(Radix Isatidis) granules
8 The Effect of 6-Methyl-Prednisolone on Organ Dysfunction and Mortality of Patients With Unresolving Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
9 Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
10 Nutritional and Metabolic Evaluation of a Tube Feeding Immune Enhancing Diet in ICU Patients Completed NCT00560157 Phase 4
11 Effect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease: Changes in Biomarkers of Oxidative Stress, Profiles of Plasma Amino Acids and Their Derivatives and Brain Function Completed NCT01662414 Phase 4
12 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
13 Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients After Intracranial Surgery (Prophylactic Analgesia and Sedation Trial, PASTrial) Completed NCT01445639 Phase 4 Dexmedetomidine;Normal saline
14 A Prospective, Open-label Study of the Structure and Function of the Retina in Adult Patients With Refractory Complex Partial Seizures Treated With Vigabatrin (Sabril®) Completed NCT01278173 Phase 4 Sabril
15 Comparison of the Analgesic Effect of the Local Anesthetics Ropicacaine, Levobupivacaine, and Levobupivacaine + Epinephrin Via Interscalene Nerve Block in Patients Undergoing Shoulder Arthroscopy Under General Anesthesia Completed NCT02691442 Phase 4 Ropivacaine 0.75%;Levobupivacaine 0.5%;Levobupivacaine 0.5% + epinephrin 1/200000
16 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy by Comparing the Change of HRV Index & ANS Function:A 6month Multicenter, Randomized, Open Label Clinical Trial CANON Study Completed NCT02056366 Phase 4 α-lipoic acid
17 An Open-label, Randomized, Multi-center Clinical Trial to Evaluate the Safety and Efficacy in Peripheral Neuropathies Patients Treated With Mecobalamin Injection Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
18 Efficacy and Safety of Pregabalin in an Open-label, Non-comparative, Flexible-dose Trial With Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
19 A 24 Week, Double-blind, Placebo-controlled, Multisite Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
20 A Multicenter Trial Evaluating the Safety and Efficacy of Cesamet™ for the Symptomatic Treatment of Chemotherapy-Induced Neuropathic Pain in Patients With Cancer Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
21 A Multicenter Trial Evaluating the Efficacy of Cesamet™ for the Symptomatic Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
22 Evaluation of a Structured Algorithm for Intrathecal Bolus Doses of Ziconotide (Prialt®)- The Swedish Ziconotide Bolus Study Completed NCT01373983 Phase 4 Ziconotide
23 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
24 A Prospective, Open-label Trial of Lidoderm® (Lidocaine Patch 5%)in Painful Diabetic and Idiopathic Neuropathy. Completed NCT00903851 Phase 4 Lidoderm
25 Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China Completed NCT01340950 Phase 4 zidovudine-lamivudine-nevirapine;tenofovir-lamivudine-efavirenz
26 A Phase IV Clinical Trial. Effect of Pulsing Electromagnetic Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
27 Phase 4 Study of Evaluation of Neural Conduction Along the Visual Pathways Before and After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
28 A Randomized, Double-Blind, Placebo-Controlled, Single Center Study Designed to Assess the Effects of Pregabalin on Change in Patients With Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
29 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
30 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
31 Comparison of the Effectiveness and Safety Between Tramadol 37.5 Mg/Acetaminophen 325mg And Gabapentin for The Treatment of Painful Diabetic Neuropathy: Multicenter, Randomized, Open Comparative Study Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
32 Long Term, Double Blind, Randomized, Placebo Controlled Multi-center Study of FRE.M.S.- Frequency Modulated Neural Stimulation Lorenz Therapy™ in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
33 A Multicenter, Phase IV, Interventional Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy Who Need Opioid Combination Treatment With Existing Pregabalin Treatment Completed NCT01675531 Phase 4 Targin
34 Study of Memantine to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Monocentric Trial Completed NCT01108029 Phase 4 memantine;placebo
35 Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentric Trial Completed NCT00914095 Phase 4 methylphenidate;placebo
36 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
37 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
38 ACTHAR Therapy for Central Nervous System Sarcoidosis Recruiting NCT02920710 Phase 4 Repository Corticotropin Injection
39 Detection of Silent Atrial Fibrillation aFter Ischemic StrOke (SAFFO) Guided by Implantable Loop Recorder. Multicentre Italian Trial Based on Stroke Unit Network With Paired Cardio-Arrhythmology Units (Italian Neurocardiology Unit Network) Recruiting NCT02684825 Phase 4
40 Multi-dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics Recruiting NCT03219008 Phase 4 Fluoxetine;fluoxetine + Amfebutamone;Fluvoxamine;Lithium+fluvoxamine;Mirtazapine/SNRIs;mirtazapine + SNRIs
41 A Double-blind, Placebo-controlled, Cross-over Study of Ranolazine in Patients With Coronary Artery Disease for the Treatment of Painful Polyneuropathy Terminated NCT00832572 Phase 4 Ranolazine;Placebo
42 Phase 4 Study of Tapentadol vs Oxycodone in Neuropathic Pain Terminated NCT01458015 Phase 4 tapentadol, oxycodone
43 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
44 A Randomized, Double-Blind, Placebo-Controlled Trial Of The Prevention And Treatment Of Chemotherapy-Induced Peripheral Neuropathy Symptoms In Subjects With Advanced Colorectal Cancer Terminated NCT00380874 Phase 4 Pregabalin;Placebo
45 Precision Spinal Cord Stimulation for Painful Diabetic Neuropathy Terminated NCT00487981 Phase 4
46 Pilot Study of L-Carnitine Supplementation in the Prevention of Chemotherapy-induced Peripheral Neuropathy in Women With Metastatic Breast Cancer Terminated NCT00754767 Phase 4 L-carnitine L-tartrate
47 Intelligent Activity-based Client-centred Training Unknown status NCT02982811 Phase 3
48 Use of Topical Lidocaine (Lidoderm 5% Patch) to Reduce Pain in Patients With Diabetic Neuropathy: Does the Density and Subtype of Sodium Channels Affect Response? Unknown status NCT01086150 Phase 2, Phase 3
49 Study of Topical Preparation of Capsaicin Nanoparticle in Patient With Painful Diabetic Neuropathy Unknown status NCT01125215 Phase 2, Phase 3 0.75% capsaicin nanoparticle cream;Placebo
50 Phase 3 Study to Evaluate Bortezomib Induced Peripheral Neuropathy of Multiple Myeloma (MM) Patients. Unknown status NCT00872352 Phase 3

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Anatomical Context for Nervous System Disease

MalaCards organs/tissues related to Nervous System Disease:

41
Brain, Breast, Spinal Cord, Bone, Heart, Testes, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Disease:

19
Central Nervous System, Peripheral Nervous System

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 2234)
# Title Authors PMID Year
1
Long non-coding RNA GAS5 promotes PC12 cells differentiation into Tuj1-positive neuron-like cells and induces cell cycle arrest. 38
31397350 2019
2
GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. 38
30513217 2019
3
Phase II study of irinotecan and temozolomide in breast cancer patients with progressing central nervous system disease. 38
31172405 2019
4
Large animal models contribute to the development of therapies for central and peripheral nervous system dysfunction in patients with lysosomal storage diseases. 38
31384936 2019
5
Peripheral nervous system disease in Systemic Lupus Erythematosus: Results from an international, inception cohort study. 38
31390162 2019
6
Neuron specific enolase as a marker of seizure related neuronal injury. 38
31404559 2019
7
Viral Sequences Detection by High-Throughput Sequencing in Cerebrospinal Fluid of Individuals with and without Central Nervous System Disease. 38
31431002 2019
8
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice. 38
31221479 2019
9
A Confocal Reflection Super-Resolution Technique to Image Golgi-Cox Stained Neurons. 38
31237354 2019
10
Comparative study of striatum GABA concentrations and magnetic resonance spectroscopic imaging in Parkinson's disease monkeys. 38
31395015 2019
11
MiR-20b-5p relieves neuropathic pain by targeting Akt3 in a chronic constriction injury rat model. 38
31381191 2019
12
Brentuximab Vedotin and High-dose Methotrexate Administrated Alternately for Refractory Anaplastic Large-cell Lymphoma With Central Nervous System Disease. 38
31274669 2019
13
Predictors of damage accrual in systemic lupus erythematosus: a longitudinal observational study with focus on neuropsychological factors and anti-neuronal antibodies. 38
31367942 2019
14
Challenges in the Daily Living Activities of Patients with Multiple Sclerosis: A Qualitative Content Analysis. 38
31341919 2019
15
Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases. 38
31078693 2019
16
Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-β-SOX9 Signaling Pathway. 38
30915623 2019
17
Gastrodin, a traditional Chinese medicine monomer compound, can be used as adjuvant to enhance the immunogenicity of melanoma vaccines. 38
31357132 2019
18
Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis. 38
31279154 2019
19
The assessment of lenticulostriate arteries originating from middle cerebral artery using ultra high-field magnetic resonance time-of-flight angiography. 38
31331750 2019
20
Neonatal Congenital Central Hypoventilation Syndrome: Why We Should not Sleep on it. Literature Review of Fourty-two Neonatal Onset Cases. 38
31223092 2019
21
[Analysis of PRF1gene variant in a child with late-onset familial hemophagocytic lymphohistiocytosis type 2 and severe central nervous system disease]. 38
31055813 2019
22
Aquaporin-4 Serostatus and Visual Outcomes in Clinically Isolated Acute Optic Neuritis. 38
30004999 2019
23
Assessing the anterior visual pathway in optic neuritis: recent experimental and clinical aspects. 38
30694926 2019
24
Meningoencephalitis due to Naegleria fowleri in cattle in southern Brazil. 38
31188946 2019
25
Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats. 38
30673960 2019
26
An unusual presentation of scleromyxedema as inflammatory myopathy. 38
31309176 2019
27
Rare and unusual case of hepatic and disseminated tuberculosis in an immunocompetent patient. 38
31229981 2019
28
The Spatial and Temporal Characters of Demyelination and Remyelination in the Cuprizone Animal Model. 38
31251832 2019
29
Procoagulant activity of bovine neutrophils incubated with conditioned media or extracellular vesicles from Histophilus somni stimulated bovine brain endothelial cells. 38
31084894 2019
30
Heart rate variability in a patient with alternating hemiplegia. 38
31218164 2019
31
Blood-based biomarkers for Alzheimer's disease-An update. 38
30352211 2019
32
The clinical significance of ubiquitin carboxyl hydrolase L1 and its autoantibody in neuropsychiatric systemic lupus erythematosus. 38
30418114 2019
33
The influence of microenvironment and extracellular matrix molecules in driving neural stem cell fate within biomaterials. 38
30898579 2019
34
Application of Virus Targeting Nanocarrier Drug Delivery System in Virus-Induced Central Nervous System Disease Treatment. 38
31067406 2019
35
Expanding the central nervous system disease spectrum associated with FLNC mutation. 38
30734317 2019
36
Multimodality Therapy of Patients with Refractory Meningiomas. 38
31073797 2019
37
Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier. 38
30971062 2019
38
Mycophenolate mofetil in the treatment of pediatric autoimmune central nervous system disease. 38
30474195 2019
39
Mortality among autoworkers manufacturing electronics in Huntsville, Alabama. 38
30569473 2019
40
Safety and Feasibility of Magnetic Resonance Imaging Simulation for Radiation Treatment Planning in Pediatric Patients: A Single Institution Experience. 38
31011682 2019
41
MicroRNAs and nervous system diseases: network insights and computational challenges. 38
30953059 2019
42
Employment characteristics and cause-specific mortality at automotive electronics manufacturing plants in Huntsville, Alabama. 38
30791109 2019
43
Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium. 38
30891696 2019
44
A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years. 38
30304904 2019
45
[Present status of diagnosis and treatment of hepatolenticular degeneration]. 38
30929331 2019
46
Magnetic resonance imaging appearance of the brain and cervical spinal cord in an edema disease affected pig. 38
28681491 2019
47
West Nile virus infection in horses in Saudi Arabia (in 2013-2015). 38
30402969 2019
48
Tinospora cordifolia Suppresses Neuroinflammation in Parkinsonian Mouse Model. 38
30644041 2019
49
Wheelchair-Assisted Ligature Strangulation: An Unusual Suicide by a Quadriparetic. 38
30920405 2019
50
Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain. 38
30871598 2019

Variations for Nervous System Disease

ClinVar genetic disease variations for Nervous System Disease:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 46;X;t(Y;3)(p11.2;p12.3)dn Translocation Likely pathogenic
2 46;XY;t(1;3)(q32.3;q21.1) Translocation Uncertain significance

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNF TBK1 SERPINA3 NOS2 MMP9 IL6
2
Show member pathways
13.7 TNF NOS2 IL6 IL1B IFNG CXCR3
3
Show member pathways
13.41 TNF IL6 IL1B CXCR3 CSF2 CCR6
4
Show member pathways
13.37 TNF NOS2 MMP9 IL6 IL1B IFNG
5
Show member pathways
13.32 TNF IL6 IL1B CXCR3 CSF2 CCR6
6
Show member pathways
13.11 TNF TBK1 NOS2 IL6 IL1B IFNG
7
Show member pathways
12.98 TNF TBK1 MMP9 IL6 IL1B CSF2
8
Show member pathways
12.78 TNF TBK1 IL6 IL1B IFNG
9
Show member pathways
12.61 TNF NOS2 IL6 IL1B IFNG
10
Show member pathways
12.59 TNF IL6 IL1B IFNG CSF2
11
Show member pathways
12.36 TNF SERPINA3 IL6 IL1B IFNG
12
Show member pathways
12.34 TNF NOS2 IL6 IL1B IFNG
13
Show member pathways
12.28 TNF NOS2 IL1B IFNG
14 12.27 PROM1 MMP9 IL6 CSF2
15 12.27 TNF NOS2 IL6 IL1B IFNG
16
Show member pathways
12.24 TNF NOS2 IL6 IL1B
17 12.23 TNF NOS2 MMP9 IL6 IFNG
18
Show member pathways
12.22 MMP9 IL1B CXCR3 CCR6 CCR1
19
Show member pathways
12.22 TNF NOS2 IL6 IL1B IFNG
20
Show member pathways
12.2 TNF TBK1 MMP9 IL6 IL1B IFNG
21 12.12 TNF MMP9 IL1B IFNG
22
Show member pathways
12.08 TNF IL6 IL1B IFNG
23 12.04 TNF IL6 IFNG CSF2 CCR1
24 12.02 TNF NOS2 MMP9 IL6 IL1B
25
Show member pathways
12.01 TNF MMP9 IL6 IL1B IFNG CSF2
26 12 TNF MMP9 IL6 IL1B CSF2
27 11.94 NOS2 IL6 IFNG
28 11.92 TNF IL6 IL1B CSF2
29 11.92 TNF NOS2 MMP9 IL6 IL1B IFNG
30 11.9 TNF IL6 IL1B
31 11.89 TNF IL6 IL1B IFNG CSF2
32 11.82 NOS2 IL6 IL1B IFNG CSF2
33 11.81 IL6 IFNG CSF2
34 11.8 TNF NOS2 IL6 IL1B
35 11.8 TNF IL1B IFNG CXCR3 CCR6
36
Show member pathways
11.77 TNF IFNG CSF2
37 11.74 TNF IL6 IL1B IFNG CSF2
38 11.74 TNF NOS2 IL6 IL1B IFNG CSF2
39 11.65 TNF MMP9 IL6 IL1B CSF2
40 11.62 TNF IL6 IL1B
41 11.61 NOS2 IL6 IFNG
42 11.59 TNF IL6 IL1B IFNG
43 11.57 TNF IL6 IFNG
44 11.57 TNF NOS2 IL1B IFNG
45 11.54 IL6 IL1B CSF2
46 11.54 TNF IL1B IFNG
47 11.54 TNF MMP9 IL6
48 11.54 TNF IL6 IL1B IFNG
49 11.49 TNF IL6 IL1B CSF2 CCR1
50 11.42 TNF IL6 IL1B IFNG

GO Terms for Nervous System Disease

Cellular components related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 TNF MOG CXCR3 CCR6 CCR1
2 extracellular space GO:0005615 9.28 TNF SERPINA3 PROM1 MMP9 IL6 IL1B

Biological processes related to Nervous System Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.93 TNF MMP9 IL1B IFNG
2 negative regulation of gene expression GO:0010629 9.93 TNF TBK1 NOS2 IFNG CCR1
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNF TBK1 MTDH IL1B
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF MTDH IL6 IL1B
5 defense response to Gram-positive bacterium GO:0050830 9.85 TNF TBK1 IL6
6 cell chemotaxis GO:0060326 9.85 CXCR3 CCR6 CCR1
7 calcium-mediated signaling GO:0019722 9.85 CXCR3 CCR6 CCR1
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.84 TNF TBK1 IL6
9 chemokine-mediated signaling pathway GO:0070098 9.84 CXCR3 CCR6 CCR1
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IL6 IFNG CSF2
11 positive regulation of interleukin-6 production GO:0032755 9.81 TNF IL6 IL1B
12 cellular response to lipopolysaccharide GO:0071222 9.8 TNF NOS2 IL6 IL1B CSF2
13 inflammatory response GO:0006954 9.8 TNF TBK1 SERPINA3 IL6 IL1B CXCR3
14 positive regulation of cytosolic calcium ion concentration GO:0007204 9.78 CXCR3 CCR6 CCR1
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF IL1B IFNG
16 immune response GO:0006955 9.76 TNF IL6 IL1B IFNG CXCR3 CSF2
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 TNF IL1B CSF2
18 regulation of insulin secretion GO:0050796 9.73 TNF NOS2 IL1B IFNG
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF MTDH IL1B
20 negative regulation of neurogenesis GO:0050768 9.69 TNF IL6 IL1B
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 TNF IL1B
22 positive regulation of podosome assembly GO:0071803 9.67 TNF CSF2
23 positive regulation of osteoclast differentiation GO:0045672 9.67 TNF IFNG CCR1
24 humoral immune response GO:0006959 9.67 TNF IL6 IFNG CCR6
25 negative regulation of lipid storage GO:0010888 9.66 TNF IL6
26 response to glucocorticoid GO:0051384 9.65 TNF IL6
27 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IL1B
28 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 TNF IL1B IFNG
31 positive regulation of interleukin-23 production GO:0032747 9.62 IFNG CSF2
32 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
33 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
34 positive regulation of killing of cells of other organism GO:0051712 9.58 NOS2 IFNG
35 positive regulation of vitamin D biosynthetic process GO:0060557 9.52 TNF IFNG
36 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
37 chronic inflammatory response to antigenic stimulus GO:0002439 9.27 TNF
38 cytokine-mediated signaling pathway GO:0019221 9.17 TNF NOS2 MMP9 IL6 IL1B CSF2
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.13 TNF IL1B IFNG
40 positive regulation of gene expression GO:0010628 10.04 TNF IL6 IL1B IFNG CSF2

Molecular functions related to Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.5 CXCR3 CCR6 CCR1
2 C-C chemokine binding GO:0019957 9.43 CXCR3 CCR6 CCR1
3 C-C chemokine receptor activity GO:0016493 9.33 CXCR3 CCR6 CCR1
4 chemokine receptor activity GO:0004950 9.13 CXCR3 CCR6 CCR1
5 cytokine activity GO:0005125 9.02 TNF IL6 IL1B IFNG CSF2

Sources for Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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