MCID: NRV007
MIFTS: 69

Nervous System Disease

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 15
Abnormality of the Nervous System 29 6
Nervous System Diseases 44
Nervous System Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:863
ICD9CM 35 349.9
MeSH 44 D009422
NCIt 50 C26835
UMLS 73 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to central nervous system disease and peripheral nervous system disease, and has symptoms including seizures, ataxia and tremor. An important gene associated with Nervous System Disease is ENSG00000179253 (), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and brain, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Nervous system diseases, also known as nervous system or neurological disorders, refers to a small class... more...

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease Autoimmune Disease of the Nervous System

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 573)
# Related Disease Score Top Affiliating Genes
1 central nervous system disease 34.5 BACE1 CCR1 CXCR3 GC IFNG IL1B
2 peripheral nervous system disease 34.4 IL6 MOG TLR9 TNF TRPV1 TUBB3
3 meningitis 32.4 IFNG IL1B IL6 MMP9 TLR9 TNF
4 multiple sclerosis 32.4 CCR1 CXCR3 IFNG IL1B IL6 MMP9
5 toxic encephalopathy 31.9 BACE1 IL1B TRPV1
6 systemic lupus erythematosus 31.0 CXCR3 IFNG IL1B IL6 TLR9 TNF
7 viral infectious disease 30.7 IFNG IL1B IL6 TBK1 TLR9 TNF
8 stomatitis 30.5 CSF2 IL1B TNF
9 arthritis 30.5 CSF2 IFNG IL1B IL6 MMP9 TNF
10 hematopoietic stem cell transplantation 30.5 IFNG IL6 TNF
11 acquired immunodeficiency syndrome 30.4 CSF2 IFNG IL1B IL6 TNF
12 human immunodeficiency virus infectious disease 30.4 IFNG IL6 TLR9 TNF
13 esophagitis 30.2 IL1B IL6 TRPV1
14 myeloma, multiple 30.2 CSF2 IL6 TLR9 TNF
15 central nervous system vasculitis 30.2 IFNG IL1B IL6 TLR9 TNF
16 chlamydia 30.2 IFNG IL1B IL6 NOS2 TNF
17 toxoplasmosis 30.1 IFNG IL1B IL6 TLR9 TNF
18 colitis 30.1 IFNG IL1B IL6 NOS2 TLR9 TNF
19 mouth disease 30.1 IFNG IL1B IL6 TLR9 TNF TRPV1
20 aseptic meningitis 30.1 IFNG IL1B TNF
21 inflammatory bowel disease 30.1 IFNG IL1B IL6 NOS2 TLR9 TNF
22 autonomic nervous system disease 12.4
23 foix-alajouanine syndrome 11.6
24 neuropathy 11.2
25 autonomic peripheral neuropathy 11.1
26 amyotrophic lateral sclerosis 1 11.1
27 pelizaeus-merzbacher disease 10.8
28 leukodystrophy, hypomyelinating, 2 10.8
29 cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome 10.8
30 combined oxidative phosphorylation deficiency 12 10.8
31 pol iii-related leukodystrophies 10.8
32 autosomal dominant leukodystrophy with autonomic disease 10.8
33 tubb4a-related leukodystrophy 10.8
34 mollaret meningitis 10.8
35 amyotrophy, hereditary neuralgic 10.8
36 arthrogryposis multiplex congenita, neurogenic type 10.8
37 central hypoventilation syndrome, congenital 10.8
38 encephalopathy, acute, infection-induced 8 10.8
39 neuromyelitis optica 10.8
40 granulomatous amebic encephalitis 10.8
41 restless legs syndrome 10.8
42 hyperekplexia 10.8
43 spinocerebellar ataxia type 1 with axonal neuropathy 10.8
44 intracranial abscess 10.8
45 meningoencephalitis 10.8
46 hemiplegia 10.8
47 epidural abscess 10.8
48 subdural empyema 10.8
49 cauda equina syndrome 10.8
50 locked-in syndrome 10.8

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:


seizures, ataxia, tremor, myoclonus, gait ataxia, back pain, vertigo, pain, agitation, clumsiness, involuntary movements, dysdiadochokinesis, action tremor, headache, bradykinesia, hemiplegia, torticollis, ophthalmoplegia, muscle fibrillation, syncope, hyperesthesia, athetosis, hemiparesis, opisthotonus, constitutional symptom, cogwheel rigidity, dysesthesia, chronic pain, sciatica, scalp tenderness, hyperalgesia, cerebellar ataxia, dizziness, staggering gait, lassitude, muscle rigidity, coarse tremor, hoarseness, bulging fontanelle, akathisia, cheyne-stokes respiration, vertigo/dizziness, equilibration disorder, sleeplessness, muscular fasciculation, symptoms, muscle spasticity, spasm, numbness, numbness localized, agitation mental, numb mouth, clouded consciousness, meningism, reflex, abnormal, spasmodic torticollis, neuralgia, adiadochokinesis, asterixis, decreased tendon reflex, musculoskeletal symptom, circumoral paresthesia, pathological conditions, signs and symptoms, asynergia, dyskinesia neonatal, non-epileptic convulsion, absence attacks, lid retraction, micropsia, leg cramps, spasm oropharyngeal, aphonia, flaccid muscle tone, flaccid paralysis, burning sensation, hypalgesia, lightheadedness, muscular stiffness, muscular incoordination, fine tremor, epileptic aura, astasia, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, limb, tremor, muscle, nerve tremors, tremor, neonatal, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, tonic seizures, extreme exhaustion, rigor - temperature-associated observation, burning mucosal, paresthesia mouth, eyes rolling, electric shock sensation, jaw stiffness, muzzy headed, motor restlessness, myotonus (finding), reaction to spinal or lumbar puncture, headache fullness

MGI Mouse Phenotypes related to Nervous System Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 BACE1 CCR1 CSF2 CXCR3 IFNG IL6
2 homeostasis/metabolism MP:0005376 10.3 BACE1 CCR1 CSF2 CXCR3 GC IFNG
3 cardiovascular system MP:0005385 10.29 CCR1 CSF2 CXCR3 IFNG IL1B IL6
4 hematopoietic system MP:0005397 10.26 CCR1 CSF2 CXCR3 IFNG IL1B IL6
5 immune system MP:0005387 10.25 CCR1 CSF2 CXCR3 IFNG IL1B IL6
6 mortality/aging MP:0010768 10.17 BACE1 CCR1 CSF2 CXCR3 IFNG IL1B
7 integument MP:0010771 10.1 BACE1 CSF2 IFNG IL1B IL6 MMP9
8 neoplasm MP:0002006 9.96 CSF2 CXCR3 IFNG IL1B IL6 MMP9
9 nervous system MP:0003631 9.93 BACE1 CSF2 IFNG IL1B IL6 MMP9
10 liver/biliary system MP:0005370 9.91 CCR1 IFNG IL6 NOS2 TBK1 TNF
11 renal/urinary system MP:0005367 9.65 CCR1 CSF2 CXCR3 IFNG IL6 MMP9
12 respiratory system MP:0005388 9.28 CCR1 CSF2 CXCR3 IFNG IL6 MMP9

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1357)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
2 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
3
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
5
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2,Not Applicable 13422-51-0 11953898 44475014
6
Methylcobalamin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 13422-55-4
7
Metformin Approved Phase 4,Phase 2,Phase 3,Not Applicable 657-24-9 14219 4091
8
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 60142-96-3 3446
9
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
10
Rivastigmine Approved, Investigational Phase 4,Phase 1 123441-03-2 77991
11
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
12
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 28523-86-6 5206
13
Chloroprocaine Approved Phase 4 133-16-4 8612
14
Levobupivacaine Approved, Investigational Phase 4,Not Applicable 27262-47-1 92253
15
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
16
Etomidate Approved Phase 4 33125-97-2 667484 36339
17
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 6740-88-1 3821
18
Clobazam Approved, Illicit Phase 4,Phase 3,Not Applicable 22316-47-8 2789
19
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
20
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
21
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
22
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
23
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
24
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
25
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
26
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 99-66-1 3121
27
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
28
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
29
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113775-47-6 68602 5311068
30
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
31
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-92-7 6047
32
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22204-53-1 1302 156391
33
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 73590-58-6 4594
34
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
35
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 51-43-4 5816
36
Racepinephrine Approved Phase 4,Phase 2,Phase 1,Not Applicable 329-65-7 838
37
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
38
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 66635-83-4, 74103-06-3 3826
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
41
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 132875-61-7 60815
42
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 437-38-7 3345
43
Ketoprofen Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 22071-15-4 3825
44
Ropivacaine Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 84057-95-4 175805 71273
45
Rocuronium Approved Phase 4,Phase 1,Phase 2,Not Applicable 119302-91-9, 143558-00-3 441290
46
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
47
Cisatracurium Approved Phase 4,Phase 3,Phase 2,Not Applicable 96946-41-7
48
Atracurium Approved, Experimental, Investigational Phase 4,Phase 3,Not Applicable 64228-79-1 47319
49
Meperidine Approved Phase 4,Phase 2,Phase 3,Not Applicable 57-42-1 4058
50
Haloperidol Approved Phase 4,Not Applicable 52-86-8 3559

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
2 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
3 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
4 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4 vitamin B12
5 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
6 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
7 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
8 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
9 Cognitive Decline in Non-demented PD Unknown status NCT01340885 Phase 4 Strattera;Exelon
10 ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study Unknown status NCT01881711 Phase 4
11 Anesthesia Induction in Patients Undergoing Surgery for Cervical Myelopathy Unknown status NCT01052337 Phase 4 anaesthetics: sevofluorane
12 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
13 Determination of the Minimum Local Analgesic Dose of Spinal Chloroprocaine in Labour Unknown status NCT01909089 Phase 4 Spinal administration of chloroprocaine.
14 IVIg for Demyelination in Diabetes Mellitus Unknown status NCT02372149 Phase 4 10% intravenous immunoglobulin (IVIg);0.9% sodium chloride
15 Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
16 Oxepa in Multiple Trauma Unknown status NCT01099501 Phase 4
17 Effects of Perampanel on Cognition and Electroencephalography in Patients With Epilepsy Unknown status NCT02900755 Phase 4 Perampanel
18 Clobazam Adjunctive Treatment of Adults With Refractory Focal Epilepsy Unknown status NCT02726919 Phase 4 Clobazam
19 Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody Unknown status NCT02695797 Phase 4 Prednisolone
20 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
21 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
22 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
23 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
24 Hormone Profiles in Adults With Newly Diagnosed Epilepsy Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
25 Study to Improve the Treatment of Epilepsy (SITE) Unknown status NCT00133081 Phase 4 All registered antiepileptic drugs
26 "Equistasi" and Gait in Hemiparesis Unknown status NCT02714478 Phase 4
27 A Study Comparing Reduction in Pain Intensity Following IV or Oral Acetaminophen Unknown status NCT02678416 Phase 4 IV Acetaminophen;IV Morphine;Acetaminophen tablets
28 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
29 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
30 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
31 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
32 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
33 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
34 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
35 Placebo In Chronic Back Pain (Phase 2) Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
36 Efficacy of the Quell Wearable Device for Chronic Low Back Pain Unknown status NCT02944513 Phase 4
37 Comparison of 1000 Hertz (Hz), Burst, and Standard Spinal Cord Stimulation in Chronic Pain Relief Unknown status NCT02902796 Phase 4
38 Local Anesthetic for Total Mastectomy Surgery Unknown status NCT02893384 Phase 4 Local Anesthetic Injection above the serratus anterior
39 Morphine Versus Ketorolac in Low Back Pain Unknown status NCT02782286 Phase 4 Ketorolac;Morphine
40 Dexamethasone in Pain Control After Total Knee Replacement Unknown status NCT02767882 Phase 4 Dexamethasone;Saline
41 VPIA Remifentanil for Labour Pain to Reduce Maternal Desaturation and Improve Analgesic Titration Unknown status NCT02733835 Phase 4 Remifentanil
42 Intraoperative Ketamine on Chronic Pain After Mastectomy Unknown status NCT02729805 Phase 4 Saline;Ketamine 0.5mg/kg;Ketamine 0.75mg/kg
43 Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
44 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
45 RCT Evaluating Intranasal Fentanyl in the Pain Management of Children With Headaches Unknown status NCT02638506 Phase 4 Fentanyl
46 Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients Unknown status NCT02620631 Phase 4 Morphine;Placebo
47 Comparison of Ketoprofen Gel to Placebo in Mechanical Low Back Pain Unknown status NCT02619695 Phase 4 Fastjel
48 Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
49 Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus Unknown status NCT02518789 Phase 4 Low-dose Dexmedetomidine;High-dose dexmedetomidine;normal saline;Etomidate;midazolam,fentanyl,rocuronium;propofol,remifentanil,cis atracurium
50 A Trial Comparing Adductor Canal Catheter and Intraarticular Catheter Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Genetic tests related to Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Nervous System 29

Anatomical Context for Nervous System Disease

MalaCards organs/tissues related to Nervous System Disease:

41
Skin, Testes, Brain, Bone, Eye, Myeloid, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Nervous System Disease:

19
The Central Nervous System Or

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 361)
# Title Authors Year
1
Predicting the incidence and timing of central nervous system disease in metastatic melanoma: Implications for surveillance and preventative therapy. ( 29332716 )
2018
2
Nervous system disease in Systemic Lupus Erythematosus: Current status and future directions. ( 29927108 )
2018
3
AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease). ( 29316812 )
2018
4
Infliximab-Associated Chronic Inflammatory Central Nervous System Disease and Peroneal Nerve Injury in a Psoriatic Patient Refractory to Treatment: Case Report with 10-Year Follow-Up. ( 29515419 )
2018
5
A matrix metalloproteinase 9 (MMP9) gene single nucleotide polymorphism is associated with predisposition to tick-borne encephalitis virus-induced severe central nervous system disease. ( 29496490 )
2018
6
Stem cells in the treatment of central nervous system disease. ( 29523970 )
2018
7
Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation. ( 30013417 )
2018
8
Rat Lungworm Infection Associated with Central Nervous System Disease - Eight U.S. States, January 2011-January 2017. ( 30070981 )
2018
9
MicroRNAs of microglia: Wrestling with central nervous system disease. ( 30323123 )
2018
10
Testing for Bartonella ssp. DNA in cerebrospinal fluid of dogs with inflammatory central nervous system disease. ( 30381844 )
2018
11
Adenovirus-Associated Central Nervous System Disease in Children. ( 30413311 )
2018
12
Potential widespread denitrosylation of brain proteins following prolonged restraint: proposed links between stress and central nervous system disease. ( 30414012 )
2018
13
Mycophenolate mofetil in the treatment of pediatric autoimmune central nervous system disease. ( 30474195 )
2018
14
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease. ( 30537919 )
2018
15
The Challenge to Search for New Nervous System Disease Biomarker Candidates: the Opportunity to Use the Proteogenomics Approach. ( 30554402 )
2018
16
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. ( 28933846 )
2017
17
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers. ( 28429106 )
2017
18
Is the Eye an Extension of the Brain in Central Nervous System Disease? ( 28609158 )
2017
19
Central Nervous System Disease in Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. ( 29061243 )
2017
20
Central nervous system disease in pediatric acute myeloid leukemia. ( 28853216 )
2017
21
Immunotherapeutics in Pediatric Autoimmune Central Nervous System Disease: Agents and Mechanisms. ( 29103429 )
2017
22
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection. ( 28927234 )
2017
23
Production of transgenic pigs using the<i>pGFAP-CreER<sup>T2</sup>;EGFP<sup>LoxP</sup></i>inducible system for central nervous system disease models. ( 29284207 )
2017
24
Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease. ( 28685189 )
2017
25
Central Nervous System Disease, Education, and Race Impact Radiation Refusal in Pediatric Cancer Patients. ( 28538508 )
2017
26
Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. ( 28453910 )
2017
27
Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study. ( 28471963 )
2017
28
Wasp Venom Immunotherapy in a Patient With Immune-Mediated Inflammatory Central Nervous System Disease: Is it Safe? ( 28398199 )
2017
29
Editorial: Induction of Central Nervous System Disease by the Adaptive Immune Response. ( 29038655 )
2017
30
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. ( 28075486 )
2017
31
Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. ( 28288111 )
2017
32
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses. ( 26861818 )
2016
33
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia. ( 26997880 )
2016
34
Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease. ( 26831951 )
2016
35
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe'sA disease). ( 27638585 )
2016
36
Glial biomarkers in human central nervous system disease. ( 27228454 )
2016
37
Association of Resident Duty Hour Restrictions on Mortality of Nervous System Disease and Disorder. ( 27777670 )
2016
38
Delivery of an adeno-associated virus vector into CSF attenuates central nervous system disease in mucopolysaccharidosis type II mice. ( 27510804 )
2016
39
The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. ( 27133811 )
2016
40
AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis. ( 27354217 )
2016
41
Hodgkin Lymphoma With Central Nervous System Disease at Primary Presentation. ( 26814676 )
2016
42
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. ( 27608169 )
2016
43
An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. ( 26843629 )
2016
44
Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. ( 27563314 )
2016
45
Central nervous system disease in childhood acute lymphoblastic leukaemia- a review. ( 26990196 )
2016
46
Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. ( 25672885 )
2015
47
Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. ( 26447927 )
2015
48
Targeted Temperature Management in Pediatric Central Nervous System Disease. ( 26042193 )
2015
49
Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. ( 25474439 )
2015
50
Flow cytometry for detection of central nervous system disease in acute myeloid leukemia. ( 25641427 )
2015

Variations for Nervous System Disease

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 CCR1 CSF2 CXCR3 IL1B IL6 TLR9
2
Show member pathways
13.38 CCR1 CSF2 IFNG IL1B IL6 MMP9
3
Show member pathways
13.32 CCR1 CSF2 CXCR3 IL1B IL6 TNF
4
Show member pathways
13.08 CCR1 CSF2 IL1B IL6 MMP9 TBK1
5
Show member pathways
13.03 IFNG IL1B IL6 NOS2 TBK1 TLR9
6
Show member pathways
12.82 IFNG IL1B IL6 TBK1 TLR9 TNF
7
Show member pathways
12.78 IFNG IL1B IL6 TBK1 TNF
8
Show member pathways
12.61 IFNG IL1B IL6 NOS2 TNF
9 12.59 IFNG IL1B TBK1 TLR9 TNF
10
Show member pathways
12.46 CSF2 IFNG IL1B IL6 TNF
11
Show member pathways
12.35 IFNG IL1B IL6 TNF
12
Show member pathways
12.35 IFNG IL1B IL6 NOS2 TNF
13
Show member pathways
12.29 IL6 TBK1 TLR9 TNF
14
Show member pathways
12.28 IFNG IL1B NOS2 TNF
15 12.28 CSF2 IL6 MMP9 PROM1
16 12.28 IFNG IL1B IL6 NOS2 TLR9 TNF
17
Show member pathways
12.28 CSF2 IFNG IL1B IL6 MMP9 TBK1
18
Show member pathways
12.24 IL1B IL6 NOS2 TNF
19
Show member pathways
12.23 IL1B IL6 TLR9 TNF
20
Show member pathways
12.23 IFNG IL1B IL6 NOS2 TLR9 TNF
21 12.22 IFNG IL6 MMP9 NOS2 TLR9 TNF
22 12.12 IFNG IL1B MMP9 TNF
23
Show member pathways
12.12 IFNG IL1B IL6 TLR9 TNF
24
Show member pathways
12.07 CSF2 IFNG IL1B