MCID: NRL008
MIFTS: 26

Neural Crest Tumor

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

MalaCards integrated aliases for Neural Crest Tumor:

Name: Neural Crest Tumor 20 70
Neural Crest-Derived Tumors 20

Classifications:



External Ids:

UMLS 70 C2931189

Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 1 and pheochromocytoma. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drug Norepinephrine has been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, eye and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.7 SDHD SDHC SDHB SDHA
2 pheochromocytoma 28.8 SDHD SDHC SDHB SDHAF2 SDHA
3 paragangliomas 4 11.2
4 paragangliomas 2 11.2
5 paragangliomas 3 11.2
6 paragangliomas 5 11.2
7 ependymoblastoma 11.2
8 adrenal gland pheochromocytoma 10.2
9 neuroblastoma 10.2
10 ganglioneuroblastoma 10.1
11 ewing sarcoma 10.1
12 gangliocytoma 10.1
13 neurilemmoma 10.1
14 ganglioneuroma 10.1
15 dermis tumor 10.0 SDHD SDHA
16 quadriplegia 10.0 SDHD SDHA
17 spastic quadriplegia 10.0 SDHD SDHA
18 spastic paraplegia 38, autosomal dominant 10.0 SDHB SDHA
19 body mass index quantitative trait locus 11 9.9
20 ataxia and polyneuropathy, adult-onset 9.9
21 body mass index quantitative trait locus 9 9.9
22 body mass index quantitative trait locus 8 9.9
23 body mass index quantitative trait locus 4 9.9
24 body mass index quantitative trait locus 10 9.9
25 body mass index quantitative trait locus 7 9.9
26 body mass index quantitative trait locus 12 9.9
27 body mass index quantitative trait locus 14 9.9
28 cyanosis, transient neonatal 9.9
29 body mass index quantitative trait locus 18 9.9
30 body mass index quantitative trait locus 19 9.9
31 diarrhea 9.9
32 toxic shock syndrome 9.9
33 olfactory neuroblastoma 9.9
34 rohhad 9.9
35 myoclonus 9.9
36 rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome 9.9
37 genetic obesity 9.9
38 sporadic pheochromocytoma/secreting paraganglioma 9.9 SDHD SDHB
39 plethora of newborn 9.9 SDHD SDHB
40 hereditary renal cell carcinoma 9.9 SDHB SDHA
41 neurofibromatosis 9.9 SDHD SDHB
42 cranial nerve palsy 9.9 SDHD SDHB
43 autonomic nervous system benign neoplasm 9.9 SDHD SDHB
44 peripheral nervous system benign neoplasm 9.9 SDHD SDHB
45 glomus tumor 9.9 SDHD SDHB
46 neurofibromatosis, type ii 9.9 SDHD SDHB
47 carney complex variant 9.8 SDHD SDHB
48 cardiovascular organ benign neoplasm 9.8 SDHD SDHB
49 kearns-sayre syndrome 9.8 SDHD SDHA
50 adrenal carcinoma 9.8 SDHD SDHB

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.32 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.32 SDHC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-141 9.32 SDHD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.32 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.32 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.32 SDHC SDHD
7 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.32 SDHC
8 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.32 SDHC
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 SDHC

Drugs & Therapeutics for Neural Crest Tumor

Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 1 51-41-2 439260

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 18F-MFBG PET Imaging of the Norepinephrine Transporter in Neural Crest and Neuroendocrine Tumors: a Phase I PET/CT Study Recruiting NCT04258592 Phase 1 (18F)MFBG

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

MalaCards organs/tissues related to Neural Crest Tumor:

40
Smooth Muscle, Eye, Lymph Node, Adrenal Gland

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show top 50) (show all 116)
# Title Authors PMID Year
1
The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma. 61
33726762 2021
2
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B. 61
33112832 2020
3
ROHHAD(NET) Syndrome: Systematic Review of the Clinical Timeline and Recommendations for Diagnosis and Prognosis. 61
32407531 2020
4
Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival. 61
32312269 2020
5
Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors. 61
32244473 2020
6
Rare neural crest tumor in teleost species: olfactory neuroblastoma in a spotted pike-characin Boulengerella maculata. 61
32052792 2020
7
Robotic approach to a subcarinal functional paraganglioma. 61
32528840 2020
8
Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1. 61
30859632 2019
9
RNA-Sequencing Analysis of Adrenocortical Carcinoma, Pheochromocytoma and Paraganglioma from a Pan-Cancer Perspective. 61
30558313 2018
10
Molecular imaging and theranostic approaches in pheochromocytoma and paraganglioma. 61
29450723 2018
11
Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging. 61
30538672 2018
12
SOX10 immunohistochemistry in sweat ductal/glandular neoplasms. 61
28343365 2017
13
CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family. 61
27428599 2017
14
Sunitinib in the therapy of malignant paragangliomas: report on the efficacy in a SDHB mutation carrier and review of the literature. 61
27737332 2017
15
The MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma. 61
27680874 2016
16
Endocrine tumors associated with the vagus nerve. 61
27406876 2016
17
ROHHAD Syndrome: The Girl who Forgets to Breathe. 61
27156551 2016
18
Parapharyngeal giant ganglioneuroma with multifocal bone involvement in a pediatric female patient. 61
29090884 2016
19
Cell Line-Dependent Variability of Coordinate Expression of p75NTR and CRABP1 and Modulation of Effects of Fenretinide on Neuroblastoma Cells. 61
26843908 2016
20
Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor. 61
26234842 2015
21
Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma. 61
26171145 2015
22
Thoracic ganglioneuromas resulting in nonimmune hydrops fetalis. 61
25032061 2014
23
Proliferation index revisited in neuroblastic tumors. 61
25310735 2014
24
Childhood pheochromocytoma in a survivor of central primitive neuroectodermal tumor. 61
23910809 2013
25
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma. 61
23314735 2013
26
Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model. 61
23333500 2013
27
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. 61
23186956 2013
28
Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma. 61
24130898 2013
29
Aberrant genes promoter methylation in neural crest-derived tumors. 61
23125005 2012
30
Sox10 and S100 in the diagnosis of soft-tissue neoplasms. 61
22495377 2012
31
Integrative analysis of neuroblastoma and pheochromocytoma genomics data. 61
23106811 2012
32
Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations. 61
22492777 2012
33
Excessive blinking and ataxia in a child with occult neuroblastoma and voltage-gated potassium channel antibodies. 61
22529275 2012
34
Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. 61
22646747 2012
35
Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients. 61
22241717 2012
36
Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development. 61
22247003 2012
37
In vitro and in vivo studies of adenovirus-mediated human norepinephrine transporter gene transduction to hepatocellular carcinoma. 61
21072068 2011
38
Cyclophosphamide for rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome. 61
20727534 2011
39
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. 61
21089070 2011
40
Pheochromocytoma and paraganglioma: current functional and future molecular imaging. 61
22655253 2011
41
Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. 61
20525240 2010
42
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. 61
20332466 2010
43
[Opsoclonus myoclonus ataxia syndrome in Israel]. 61
20422836 2010
44
Primary carcinoma of the lung in von Recklinghausen neurofibromatosis. 61
20531996 2009
45
Pheochromocytomas: from genetic diversity to new paradigms. 61
19391076 2009
46
Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors. 61
19154261 2009
47
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. 61
18726616 2008
48
Rare occurrence of PHOX2b mutations in sporadic neuroblastomas. 61
19011468 2008
49
Sox10: a pan-schwannian and melanocytic marker. 61
18636017 2008
50
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. 61
18334619 2008

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

Pathways related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 SDHD SDHC SDHB SDHA
2
Show member pathways
12.76 SDHD SDHC SDHB SDHA
3
Show member pathways
12.28 SDHD SDHC SDHB SDHA
4
Show member pathways
11.78 SDHD SDHC SDHB SDHA
5
Show member pathways
11.37 SDHD SDHC SDHB SDHA
6
Show member pathways
10.94 SDHD SDHC SDHB SDHA

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHD SDHC SDHB SDHAF2 SDHA
2 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
3 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.62 SDHD SDHC SDHB SDHA
2 aerobic respiration GO:0009060 9.4 SDHC SDHB
3 respiratory electron transport chain GO:0022904 9.37 SDHB SDHA
4 electron transport chain GO:0022900 9.33 SDHC SDHB SDHA
5 succinate metabolic process GO:0006105 9.26 SDHB SDHA
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHD SDHC SDHAF2 SDHA
7 tricarboxylic acid cycle GO:0006099 9.02 SDHD SDHC SDHB SDHAF2 SDHA

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.37 SDHD SDHC
2 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
3 ubiquinone binding GO:0048039 9.26 SDHD SDHB
4 electron transfer activity GO:0009055 9.26 SDHD SDHC SDHB SDHA
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.16 SDHB SDHA
6 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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