MCID: NRL008
MIFTS: 26

Neural Crest Tumor

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

MalaCards integrated aliases for Neural Crest Tumor:

Name: Neural Crest Tumor 53 73
Neural Crest-Derived Tumors 53

Classifications:



External Ids:

UMLS 73 C2931189

Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 1 and ependymoblastoma. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.0 SDHB SDHC SDHD
2 ependymoblastoma 11.0
3 paragangliomas 4 11.0
4 paragangliomas 2 11.0
5 paragangliomas 3 11.0
6 paragangliomas 5 11.0
7 beckwith-wiedemann syndrome 9.9
8 neuroblastoma 9.9
9 seminal vesicle tumor 9.9 SDHA SDHB
10 ataxia-oculomotor apraxia 3 9.8
11 diarrhea 9.8
12 hypothalamic disease 9.8
13 aceruloplasminemia 9.8
14 glomus tumor 9.8 SDHB SDHD
15 multiple endocrine neoplasia, type iia 9.7 SDHB SDHD
16 kearns-sayre syndrome 9.7 SDHA SDHD
17 multiple endocrine neoplasia 9.2 SDHB SDHC
18 multiple endocrine neoplasia, type i 9.2 SDHB SDHD
19 leigh syndrome 9.1 SDHA SDHB SDHD
20 chondroma 9.0 SDHB SDHC SDHD
21 paraganglioma and gastric stromal sarcoma 9.0 SDHB SDHC SDHD
22 sporadic pheochromocytoma 8.9 SDHB SDHC SDHD
23 lymphatic system disease 8.9 SDHB SDHC SDHD
24 neurofibromatosis, type iv, of riccardi 8.9 SDHB SDHC SDHD
25 von hippel-lindau syndrome 8.9 SDHB SDHC SDHD
26 cowden disease 8.9 SDHB SDHC SDHD
27 endocrine gland cancer 8.8 SDHB SDHC SDHD
28 carney triad 8.5 SDHA SDHB SDHC SDHD
29 gastrointestinal stromal tumor 8.4 SDHA SDHB SDHC SDHD
30 adrenal medulla cancer 8.4 SDHAF2 SDHB SDHC SDHD
31 extra-adrenal pheochromocytoma 8.4 SDHAF2 SDHB SDHC SDHD
32 phaeochromocytoma 8.4 SDHAF2 SDHB SDHC SDHD
33 persistent generalized lymphadenopathy 7.9 SDHA SDHAF2 SDHB SDHC SDHD
34 lymph node disease 7.9 SDHA SDHAF2 SDHB SDHC SDHD
35 hereditary paraganglioma-pheochromocytoma syndromes 7.9 SDHA SDHAF2 SDHB SDHC SDHD
36 mitochondrial complex ii deficiency 7.9 SDHA SDHAF2 SDHB SDHC SDHD
37 paraganglioma 7.9 SDHA SDHAF2 SDHB SDHC SDHD
38 pheochromocytoma 7.8 SDHA SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Neural Crest Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 I-123-MIBG for Imaging of Neuroblastoma and Pheochromocytoma Completed NCT00590096
2 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274
3 Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS) Recruiting NCT03568669
4 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show all 11)
# Title Authors Year
1
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. ( 23186956 )
2013
2
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. ( 23474632 )
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. ( 14515390 )
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. ( 12632821 )
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. ( 9185210 )
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). ( 8578645 )
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. ( 2068150 )
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. ( 2748231 )
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. ( 7105037 )
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. ( 7435465 )
1980
11
Convulsions with an occult neural-crest tumor. ( 460316 )
1979

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHA SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.46 SDHA SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.62 SDHA SDHB SDHC SDHD
2 aerobic respiration GO:0009060 9.4 SDHB SDHC
3 respiratory electron transport chain GO:0022904 9.37 SDHA SDHB
4 electron transport chain GO:0022900 9.33 SDHA SDHB SDHC
5 succinate metabolic process GO:0006105 9.26 SDHA SDHB
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHA SDHAF2 SDHC SDHD
7 tricarboxylic acid cycle GO:0006099 9.02 SDHA SDHAF2 SDHB SDHC SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
2 heme binding GO:0020037 9.37 SDHC SDHD
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHA SDHC
4 ubiquinone binding GO:0048039 9.26 SDHB SDHD
5 succinate dehydrogenase activity GO:0000104 9.13 SDHA SDHC SDHD
6 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 SDHA SDHB SDHC SDHD

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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