MCID: NRL008
MIFTS: 27

Neural Crest Tumor

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

MalaCards integrated aliases for Neural Crest Tumor:

Name: Neural Crest Tumor 52 71
Neural Crest-Derived Tumors 52

Classifications:



External Ids:

UMLS 71 C2931189

Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 1 and pheochromocytoma. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Affiliated tissues include thyroid, lung and smooth muscle, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.9 SDHD SDHC SDHB
2 pheochromocytoma 28.5 SDHD SDHC SDHB SDHAF2 SDHA
3 paraganglioma 27.7 SDHD SDHC SDHB SDHAF2 SDHA
4 paragangliomas 2 11.7
5 paragangliomas 4 11.3
6 paragangliomas 3 11.3
7 paragangliomas 5 11.3
8 paragangliomas 6 11.3
9 paragangliomas 7 11.3
10 ependymoblastoma 11.3
11 neuroblastoma 10.5
12 adrenal gland pheochromocytoma 10.4
13 thyroid carcinoma 10.2
14 melanoma 10.2
15 thyroid carcinoma, familial medullary 10.1
16 malignant pheochromocytoma 10.1
17 thyroid gland medullary carcinoma 10.1
18 beckwith-wiedemann syndrome 10.0
19 ataxia and polyneuropathy, adult-onset 10.0
20 aceruloplasminemia 10.0
21 diarrhea 10.0
22 gangliocytoma 10.0
23 ganglioneuroblastoma 10.0
24 ganglioneuroma 10.0
25 ewing sarcoma 10.0
26 askin's tumor 10.0
27 rhabdomyosarcoma 10.0
28 skin melanoma 10.0
29 leiomyoma cutis 10.0 SDHD SDHA
30 hypertension, essential 9.9
31 medulloblastoma 9.9
32 wilms tumor 1 9.9
33 neuroblastoma 1 9.9
34 meningioma, radiation-induced 9.9
35 meningioma, familial 9.9
36 cyanosis, transient neonatal 9.9
37 infantile myofibromatosis 9.9
38 spinal meningioma 9.9
39 conn's syndrome 9.9
40 toxic shock syndrome 9.9
41 glioblastoma multiforme 9.9
42 astrocytoma 9.9
43 neurilemmoma 9.9
44 secretory meningioma 9.9
45 lymphoplasmacyte-rich meningioma 9.9
46 benign ependymoma 9.9
47 cellular ependymoma 9.9
48 neurofibroma 9.9
49 47,xyy 9.9
50 48,xyyy 9.9

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.23 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.23 SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.23 SDHC SDHD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.23 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.23 SDHC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.23 SDHC SDHD

MGI Mouse Phenotypes related to Neural Crest Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.02 SDHA SDHAF2 SDHB SDHC SDHD

Drugs & Therapeutics for Neural Crest Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

MalaCards organs/tissues related to Neural Crest Tumor:

40
Thyroid, Lung, Smooth Muscle, Eye, Bone, Lymph Node, Adrenal Gland

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show top 50) (show all 109)
# Title Authors PMID Year
1
Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1. 61
30859632 2019
2
RNA-Sequencing Analysis of Adrenocortical Carcinoma, Pheochromocytoma and Paraganglioma from a Pan-Cancer Perspective. 61
30558313 2018
3
Molecular imaging and theranostic approaches in pheochromocytoma and paraganglioma. 61
29450723 2018
4
Update of Pheochromocytoma Syndromes: Genetics, Biochemical Evaluation, and Imaging. 61
30538672 2018
5
SOX10 immunohistochemistry in sweat ductal/glandular neoplasms. 61
28343365 2017
6
CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family. 61
27428599 2017
7
Sunitinib in the therapy of malignant paragangliomas: report on the efficacy in a SDHB mutation carrier and review of the literature. 61
27737332 2017
8
The MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma. 61
27680874 2016
9
Endocrine tumors associated with the vagus nerve. 61
27406876 2016
10
ROHHAD Syndrome: The Girl who Forgets to Breathe. 61
27156551 2016
11
Parapharyngeal giant ganglioneuroma with multifocal bone involvement in a pediatric female patient. 61
29090884 2016
12
Cell Line-Dependent Variability of Coordinate Expression of p75NTR and CRABP1 and Modulation of Effects of Fenretinide on Neuroblastoma Cells. 61
26843908 2016
13
Rare Middle Mediastinal Paraganglioma Mimicking Metastatic Neuroendocrine Tumor. 61
26234842 2015
14
Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma. 61
26171145 2015
15
Thoracic ganglioneuromas resulting in nonimmune hydrops fetalis. 61
25032061 2014
16
Proliferation index revisited in neuroblastic tumors. 61
25310735 2014
17
Childhood pheochromocytoma in a survivor of central primitive neuroectodermal tumor. 61
23910809 2013
18
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma. 61
23314735 2013
19
Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model. 61
23333500 2013
20
Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of neuroblastoma. 61
24130898 2013
21
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. 61
23186956 2013
22
Aberrant genes promoter methylation in neural crest-derived tumors. 61
23125005 2012
23
Sox10 and S100 in the diagnosis of soft-tissue neoplasms. 61
22495377 2012
24
Integrative analysis of neuroblastoma and pheochromocytoma genomics data. 61
23106811 2012
25
Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations. 61
22492777 2012
26
Excessive blinking and ataxia in a child with occult neuroblastoma and voltage-gated potassium channel antibodies. 61
22529275 2012
27
Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. 61
22646747 2012
28
Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients. 61
22241717 2012
29
Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development. 61
22247003 2012
30
In vitro and in vivo studies of adenovirus-mediated human norepinephrine transporter gene transduction to hepatocellular carcinoma. 61
21072068 2011
31
Cyclophosphamide for rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome. 61
20727534 2011
32
Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. 61
21089070 2011
33
Pheochromocytoma and paraganglioma: current functional and future molecular imaging. 61
22655253 2011
34
Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. 61
20525240 2010
35
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. 61
20332466 2010
36
[Opsoclonus myoclonus ataxia syndrome in Israel]. 61
20422836 2010
37
Primary carcinoma of the lung in von Recklinghausen neurofibromatosis. 61
20531996 2009
38
Pheochromocytomas: from genetic diversity to new paradigms. 61
19391076 2009
39
Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors. 61
19154261 2009
40
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors. 61
18726616 2008
41
Rare occurrence of PHOX2b mutations in sporadic neuroblastomas. 61
19011468 2008
42
Sox10: a pan-schwannian and melanocytic marker. 61
18636017 2008
43
The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. 61
18334619 2008
44
ALK is a novel dependence receptor: potential implications in development and cancer. 61
17611412 2007
45
Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization. 61
16513255 2007
46
Relevance of the neuropeptide Y system in the biology of cancer progression. 61
17979777 2007
47
Current concepts in RET-related genetics, signaling and therapeutics. 61
16979782 2006
48
Management and treatment of pheochromocytomas and paragangliomas. 61
17102109 2006
49
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas. 61
17102089 2006
50
Glial cell line-derived neurotrophic factor (GDNF) family ligands reduce the sensitivity of neuroblastoma cells to pharmacologically induced cell death, growth arrest and differentiation. 61
16125842 2005

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHD SDHC SDHB SDHAF2 SDHA
2 mitochondrial inner membrane GO:0005743 9.46 SDHD SDHC SDHB SDHA
3 respiratory chain complex II GO:0045273 8.96 SDHC SDHB
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHD SDHC SDHB SDHA

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.62 SDHD SDHC SDHB SDHA
2 aerobic respiration GO:0009060 9.4 SDHC SDHB
3 respiratory electron transport chain GO:0022904 9.37 SDHB SDHA
4 electron transport chain GO:0022900 9.33 SDHC SDHB SDHA
5 succinate metabolic process GO:0006105 9.26 SDHB SDHA
6 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.26 SDHD SDHC SDHAF2 SDHA
7 tricarboxylic acid cycle GO:0006099 9.02 SDHD SDHC SDHB SDHAF2 SDHA

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transfer activity GO:0009055 9.46 SDHD SDHC SDHB SDHA
2 heme binding GO:0020037 9.37 SDHD SDHC
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHC SDHA
4 ubiquinone binding GO:0048039 9.26 SDHD SDHB
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHD SDHB SDHA
6 succinate dehydrogenase activity GO:0000104 8.8 SDHD SDHC SDHA

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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