NTDFS
MCID: NRL018
MIFTS: 53

Neural Tube Defects, Folate-Sensitive (NTDFS)

Categories: Genetic diseases

Aliases & Classifications for Neural Tube Defects, Folate-Sensitive

MalaCards integrated aliases for Neural Tube Defects, Folate-Sensitive:

Name: Neural Tube Defects, Folate-Sensitive 57 75 29 6 40
Neural Tube Defects, Folate-Sensitive, Susceptibility to 57 13 6
Neural Tube Defect, Folate-Sensitive 76 73
Ntdfs 57 75
Neural Tube Defects, Susceptibility to 57
Ntd, Folate-Sensitive 57
Neural Tube Defects 57

Characteristics:

OMIM:

57
Inheritance:
? autosomal recessive


Classifications:



External Ids:

OMIM 57 601634
SNOMED-CT via HPO 69 253098009
UMLS 73 C1866558

Summaries for Neural Tube Defects, Folate-Sensitive

OMIM : 57 Neural tube defects have a birth incidence of approximately 1 in 1,000 in American Caucasians and are the second most common type of birth defect after congenital heart defects. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly (206500) (Detrait et al., 2005). Women with elevated plasma homocysteine, low folate, or low vitamin B12 (cobalamin) are at increased risk of having a child with a neural tube defect (O'Leary et al., 2005). Motulsky (1996) cited evidence from the Centers for Disease Control ( Anonymous, 1992) that folic acid given before and during the first 4 weeks of pregnancy can prevent 50% or more of neural tube defects. Botto et al. (1999) and Detrait et al. (2005) provided reviews of neural tube defects. De Marco et al. (2006) provided a detailed review of neurulation and the possible etiologies of neural tube defects. (601634)

MalaCards based summary : Neural Tube Defects, Folate-Sensitive, also known as neural tube defects, folate-sensitive, susceptibility to, is related to neural tube defects and anencephaly. An important gene associated with Neural Tube Defects, Folate-Sensitive is MTHFD1 (Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Selenium Micronutrient Network. Affiliated tissues include heart, bone and brain, and related phenotypes are abnormality of metabolism/homeostasis and spinal dysraphism

UniProtKB/Swiss-Prot : 75 Neural tube defects, folate-sensitive: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.

Wikipedia : 76 Neurulation refers to the folding process in vertebrate embryos, which includes the transformation of... more...

Related Diseases for Neural Tube Defects, Folate-Sensitive

Diseases related to Neural Tube Defects, Folate-Sensitive via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 neural tube defects 34.1 MTHFD1 MTHFR MTR MTRR
2 anencephaly 32.3 MTHFD1 MTHFR MTR MTRR
3 cleft lip 30.0 MTHFR MTRR
4 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 29.8 MTHFR MTR
5 vitamin b12 deficiency 29.8 MTHFR MTR
6 vascular disease 29.7 MTHFR MTR MTRR
7 homocystinuria 29.6 MTHFR MTR MTRR
8 neural tube defects, x-linked 12.6
9 craniofacial abnormalities, cataracts, congenital heart disease, sacral neural tube defects, and growth and developmental retardation 12.4
10 encephalocele 11.7
11 iniencephaly 11.6
12 mthfr gene variant 11.6
13 craniorachischisis 11.4
14 chiari malformation 11.4
15 fryns microphthalmia syndrome 11.1
16 hyperthermia induced defects 11.1
17 limb-body wall complex 11.1
18 meningoencephalocele 11.1
19 schisis association 11.1
20 down syndrome 10.3
21 hydrocephalus 10.3
22 omphalocele 10.2
23 myelomeningocele 10.2
24 waardenburg's syndrome 10.2
25 exencephaly 10.2
26 spondylocostal dysostosis 1, autosomal recessive 10.1
27 lipomyelomeningocele 10.1
28 malaria 10.1
29 hyperglycemia 10.1
30 spondylocostal dysostosis 1 10.1
31 upper thoracic spina bifida cystica 10.1 MTHFD1 MTHFR
32 cervicothoracic spina bifida cystica 10.1 MTHFD1 MTHFR
33 cervical spina bifida cystica 10.1 MTHFD1 MTHFR
34 lumbosacral spina bifida cystica 10.1 MTHFD1 MTHFR
35 thoracolumbosacral spina bifida cystica 10.1 MTHFD1 MTHFR
36 total spina bifida cystica 10.1 MTHFD1 MTHFR
37 upper thoracic spina bifida aperta 10.1 MTHFD1 MTHFR
38 thoracolumbosacral spina bifida aperta 10.1 MTHFD1 MTHFR
39 lumbosacral spina bifida aperta 10.1 MTHFD1 MTHFR
40 cervical spina bifida aperta 10.1 MTHFD1 MTHFR
41 cervicothoracic spina bifida aperta 10.1 MTHFD1 MTHFR
42 total spina bifida aperta 10.1 MTHFD1 MTHFR
43 nondisjunction 10.1 MTHFR MTRR
44 schizophrenia 10.1
45 body mass index quantitative trait locus 1 10.1
46 fetal alcohol syndrome 10.1
47 alcohol-related birth defect 10.1
48 heart disease 10.1
49 congenital hydrocephalus 10.1
50 cardia cancer 10.1 MTHFR MTRR

Graphical network of the top 20 diseases related to Neural Tube Defects, Folate-Sensitive:



Diseases related to Neural Tube Defects, Folate-Sensitive

Symptoms & Phenotypes for Neural Tube Defects, Folate-Sensitive

Symptoms via clinical synopsis from OMIM:

57
Metabolic:
maternal abnormal homocysteine metabolism.

Lab:
thermolabile form of mthfr

Misc:
increased (7-fold) risk for ntd
folate-sensitive


Clinical features from OMIM:

601634

Human phenotypes related to Neural Tube Defects, Folate-Sensitive:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis 32 HP:0001939
2 spinal dysraphism 32 HP:0010301

Drugs & Therapeutics for Neural Tube Defects, Folate-Sensitive

Search Clinical Trials , NIH Clinical Center for Neural Tube Defects, Folate-Sensitive

Genetic Tests for Neural Tube Defects, Folate-Sensitive

Genetic tests related to Neural Tube Defects, Folate-Sensitive:

# Genetic test Affiliating Genes
1 Neural Tube Defects, Folate-Sensitive 29 MTHFD1 MTHFR MTR MTRR

Anatomical Context for Neural Tube Defects, Folate-Sensitive

MalaCards organs/tissues related to Neural Tube Defects, Folate-Sensitive:

41
Heart, Bone, Brain, Colon, Placenta, Testes, Thyroid

Publications for Neural Tube Defects, Folate-Sensitive

Articles related to Neural Tube Defects, Folate-Sensitive:

(show top 50) (show all 1165)
# Title Authors Year
1
Regulation of the expression of tumor necrosis factora89related genes by abnormal histone H3K27 acetylation: Implications for neural tube defects. ( 29693124 )
2018
2
Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia. ( 29713643 )
2018
3
Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects. ( 29358613 )
2018
4
A public health approach for preventing neural tube defects: folic acid fortification and beyond. ( 29450891 )
2018
5
Genetic screening and functional analysis of CASP9 mutations in a Chinese cohort with neural tube defects. ( 29365368 )
2018
6
Letter to the Editor. Family history of neural tube defects. ( 29303457 )
2018
7
Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. ( 29725084 )
2018
8
Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects. ( 29309894 )
2018
9
Correction to: Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China. ( 29445915 )
2018
10
Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China. ( 29392422 )
2018
11
Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. ( 29900595 )
2018
12
LRP2 gene variants and their haplotypes strongly influence the risk of developing neural tube defects in the fetus: a family-triad study from South India. ( 29728895 )
2018
13
Neurological outcomes by mode of delivery for fetuses with open neural tube defects: A systematic review and meta-analysis. ( 29924919 )
2018
14
Comments on "ambient and dosed exposure to quaternary ammonium disinfectants causes neural tube defects in rodents". ( 29388359 )
2018
15
Genetic contribution of retinoid-related genes to neural tube defects. ( 29297599 )
2018
16
Low carbohydrate diets may increase risk of neural tube defects. ( 29368448 )
2018
17
Neural Tube Defects in Embryonic Life: Lessons Learned From 340 Early Pregnancy Failures. ( 29665042 )
2018
18
Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. ( 29732722 )
2018
19
Novel mutation in SP2 in a Chinese pedigree with Neural tube defects. ( 29855149 )
2018
20
Chornobyl, radiation, neural tube defects, and microcephaly. ( 29908351 )
2018
21
Maternal dietary nitrate intake and risk of neural tube defects: A systematic review and dose-response meta-analysis. ( 29763679 )
2018
22
Should vitamin B<sub>12</sub>status be considered in assessing risk of neural tube defects? ( 29377209 )
2018
23
Isolated Post-Shunt Metopic Synostosis and Neural Tube Defects. ( 29561489 )
2018
24
NMDA Receptor Signaling Is Important for Neural Tube Formation and for Preventing Antiepileptic Drug-Induced Neural Tube Defects. ( 29712790 )
2018
25
Estimates of global and regional prevalence of neural tube defects for 2015: a systematic analysis. ( 29363759 )
2018
26
Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers. ( 29222906 )
2018
27
Formate rescues neural tube defects caused by mutations in <i>Slc25a32</i>. ( 29666258 )
2018
28
Public health failure in the prevention of neural tube defects: time to abandon the tolerable upper intake level of folate. ( 29450103 )
2018
29
Rare mutations inapoptosis related genes APAF1, CASP9, and CASP3 contribute to human neural tube defects. ( 29352212 )
2018
30
Fetoscopic Two-Layers Closure of Open Neural Tube Defects. ( 29876992 )
2018
31
Folic acid and primary prevention of neural tube defects: A review. ( 29777755 )
2018
32
Comments on &amp;quot;Low carbohydrate diets may increase risk of neural tube defects&amp;quot;. ( 29797554 )
2018
33
Fortifying food with folic acid to prevent neural tube defects: are we now where we ought to be? ( 29868919 )
2018
34
Comments on "Clinical profile of neural tube defects in Sudanese children: Is malaria a risk factor?" ( 30166767 )
2018
35
Neural tube defects and malaria. ( 30166768 )
2018
36
Reply: Response to letters to the editor on neural tube defects and malaria. ( 30168537 )
2018
37
Reducing inequities in preventable neural tube defects: the critical and underutilized role of neurosurgical advocacy for folate fortification. ( 30269587 )
2018
38
An Audit of Neural Tube Defects in the Republic Of Ireland for 2012-2015. ( 30376230 )
2018
39
Sex differences in the prevalence of neural tube defects and preventive effects of folic acid (FA) supplementation among five counties in northern China: results from a population-based birth defect surveillance programme. ( 30413501 )
2018
40
Whole exome sequencing identifies novel predisposing genes in neural tube defects. ( 30415495 )
2018
41
Overview on neural tube defects: From development to physical characteristics. ( 30421543 )
2018
42
High burden of neural tube defects in Tigray, Northern Ethiopia: Hospital-based study. ( 30427877 )
2018
43
Maternal Diabetes and Fetal Programming Toward Neurological Diseases: Beyond Neural Tube Defects. ( 30483218 )
2018
44
Maternal periconceptional consumption of sprouted potato and risks of neural tube defects and orofacial clefts. ( 30486846 )
2018
45
Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study. ( 30507621 )
2018
46
Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study. ( 30541549 )
2018
47
Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. ( 30545932 )
2018
48
Systematic review of clinician awareness of mycotoxin impact in neural tube defects and best practices for pediatric neurosurgeons: implications for public health and policy. ( 30552445 )
2018
49
Quantitative Measurement of PARD3 Copy Number Variations in Human Neural Tube Defects. ( 28623428 )
2018
50
Novel Mutation of LRP6 Identified in Chinese Han Population Links Canonical WNT Signaling to Neural Tube Defects. ( 28960852 )
2018

Variations for Neural Tube Defects, Folate-Sensitive

UniProtKB/Swiss-Prot genetic disease variations for Neural Tube Defects, Folate-Sensitive:

75
# Symbol AA change Variation ID SNP ID
1 MTHFD1 p.Arg293His VAR_010241 rs34181110
2 MTHFD1 p.Arg653Gln VAR_010251 rs2236225

ClinVar genetic disease variations for Neural Tube Defects, Folate-Sensitive:

6 (show top 50) (show all 219)
# Gene Variation Type Significance SNP ID Assembly Location
1 MTHFR NM_005957.4(MTHFR): c.665C> T (p.Ala222Val) single nucleotide variant drug response rs1801133 GRCh37 Chromosome 1, 11856378: 11856378
2 MTHFR NM_005957.4(MTHFR): c.665C> T (p.Ala222Val) single nucleotide variant drug response rs1801133 GRCh38 Chromosome 1, 11796321: 11796321
3 MTHFR NM_005957.4(MTHFR): c.1286A> C (p.Glu429Ala) single nucleotide variant Conflicting interpretations of pathogenicity, other, risk factor rs1801131 GRCh37 Chromosome 1, 11854476: 11854476
4 MTHFR NM_005957.4(MTHFR): c.1286A> C (p.Glu429Ala) single nucleotide variant Conflicting interpretations of pathogenicity, other, risk factor rs1801131 GRCh38 Chromosome 1, 11794419: 11794419
5 MTRR NM_002454.2(MTRR): c.66A> G (p.Ile22Met) single nucleotide variant drug response rs1801394 GRCh37 Chromosome 5, 7870973: 7870973
6 MTRR NM_002454.2(MTRR): c.66A> G (p.Ile22Met) single nucleotide variant drug response rs1801394 GRCh38 Chromosome 5, 7870860: 7870860
7 MTHFD1 NM_005956.3(MTHFD1): c.1958G> A (p.Arg653Gln) single nucleotide variant Benign rs2236225 GRCh37 Chromosome 14, 64908845: 64908845
8 MTHFD1 NM_005956.3(MTHFD1): c.1958G> A (p.Arg653Gln) single nucleotide variant Benign rs2236225 GRCh38 Chromosome 14, 64442127: 64442127
9 MTR MTR, 2756A-G single nucleotide variant risk factor
10 MTHFR NM_005957.4(MTHFR): c.1305C> T (p.Phe435=) single nucleotide variant Benign rs4846051 GRCh37 Chromosome 1, 11854457: 11854457
11 MTHFR NM_005957.4(MTHFR): c.1305C> T (p.Phe435=) single nucleotide variant Benign rs4846051 GRCh38 Chromosome 1, 11794400: 11794400
12 MTHFR NM_005957.4(MTHFR): c.1004G> A (p.Arg335His) single nucleotide variant Uncertain significance rs543016186 GRCh37 Chromosome 1, 11855182: 11855182
13 MTHFR NM_005957.4(MTHFR): c.1004G> A (p.Arg335His) single nucleotide variant Uncertain significance rs543016186 GRCh38 Chromosome 1, 11795125: 11795125
14 MTHFR NM_005957.4(MTHFR): c.1781G> A (p.Arg594Gln) single nucleotide variant Benign/Likely benign, other rs2274976 GRCh37 Chromosome 1, 11850927: 11850927
15 MTHFR NM_005957.4(MTHFR): c.1781G> A (p.Arg594Gln) single nucleotide variant Benign/Likely benign, other rs2274976 GRCh38 Chromosome 1, 11790870: 11790870
16 MTHFR NM_005957.4(MTHFR): c.*4900C> T single nucleotide variant Uncertain significance rs539181268 GRCh38 Chromosome 1, 11785780: 11785780
17 MTHFR NM_005957.4(MTHFR): c.*4900C> T single nucleotide variant Uncertain significance rs539181268 GRCh37 Chromosome 1, 11845837: 11845837
18 MTHFR NM_005957.4(MTHFR): c.*4791G> A single nucleotide variant Likely benign rs12023469 GRCh38 Chromosome 1, 11785889: 11785889
19 MTHFR NM_005957.4(MTHFR): c.*4791G> A single nucleotide variant Likely benign rs12023469 GRCh37 Chromosome 1, 11845946: 11845946
20 MTHFR NM_005957.4(MTHFR): c.*4679C> T single nucleotide variant Uncertain significance rs185982649 GRCh38 Chromosome 1, 11786001: 11786001
21 MTHFR NM_005957.4(MTHFR): c.*4679C> T single nucleotide variant Uncertain significance rs185982649 GRCh37 Chromosome 1, 11846058: 11846058
22 MTHFR NM_005957.4(MTHFR): c.*4506T> G single nucleotide variant Uncertain significance rs886045168 GRCh38 Chromosome 1, 11786174: 11786174
23 MTHFR NM_005957.4(MTHFR): c.*4506T> G single nucleotide variant Uncertain significance rs886045168 GRCh37 Chromosome 1, 11846231: 11846231
24 MTHFR NM_005957.4(MTHFR): c.*4505C> T single nucleotide variant Uncertain significance rs369609825 GRCh38 Chromosome 1, 11786175: 11786175
25 MTHFR NM_005957.4(MTHFR): c.*4505C> T single nucleotide variant Uncertain significance rs369609825 GRCh37 Chromosome 1, 11846232: 11846232
26 MTHFR NM_005957.4(MTHFR): c.*4168A> C single nucleotide variant Uncertain significance rs774295533 GRCh38 Chromosome 1, 11786512: 11786512
27 MTHFR NM_005957.4(MTHFR): c.*4168A> C single nucleotide variant Uncertain significance rs774295533 GRCh37 Chromosome 1, 11846569: 11846569
28 MTHFR NM_005957.4(MTHFR): c.*4041G> A single nucleotide variant Uncertain significance rs886045173 GRCh38 Chromosome 1, 11786639: 11786639
29 MTHFR NM_005957.4(MTHFR): c.*4041G> A single nucleotide variant Uncertain significance rs886045173 GRCh37 Chromosome 1, 11846696: 11846696
30 MTHFR NM_005957.4(MTHFR): c.*3963G> C single nucleotide variant Uncertain significance rs886045174 GRCh38 Chromosome 1, 11786717: 11786717
31 MTHFR NM_005957.4(MTHFR): c.*3963G> C single nucleotide variant Uncertain significance rs886045174 GRCh37 Chromosome 1, 11846774: 11846774
32 MTHFR NM_005957.4(MTHFR): c.*3158G> A single nucleotide variant Uncertain significance rs886045177 GRCh37 Chromosome 1, 11847579: 11847579
33 MTHFR NM_005957.4(MTHFR): c.*3158G> A single nucleotide variant Uncertain significance rs886045177 GRCh38 Chromosome 1, 11787522: 11787522
34 MTHFR NM_005957.4(MTHFR): c.*3088C> T single nucleotide variant Uncertain significance rs538074274 GRCh37 Chromosome 1, 11847649: 11847649
35 MTHFR NM_005957.4(MTHFR): c.*3088C> T single nucleotide variant Uncertain significance rs538074274 GRCh38 Chromosome 1, 11787592: 11787592
36 MTHFR NM_005957.4(MTHFR): c.*3046G> A single nucleotide variant Uncertain significance rs569629260 GRCh37 Chromosome 1, 11847691: 11847691
37 MTHFR NM_005957.4(MTHFR): c.*3046G> A single nucleotide variant Uncertain significance rs569629260 GRCh38 Chromosome 1, 11787634: 11787634
38 MTHFR NM_005957.4(MTHFR): c.*2965C> A single nucleotide variant Likely benign rs3820192 GRCh37 Chromosome 1, 11847772: 11847772
39 MTHFR NM_005957.4(MTHFR): c.*2965C> A single nucleotide variant Likely benign rs3820192 GRCh38 Chromosome 1, 11787715: 11787715
40 MTHFR NM_005957.4(MTHFR): c.*2835G> T single nucleotide variant Likely benign rs1537515 GRCh37 Chromosome 1, 11847902: 11847902
41 MTHFR NM_005957.4(MTHFR): c.*2835G> T single nucleotide variant Likely benign rs1537515 GRCh38 Chromosome 1, 11787845: 11787845
42 MTHFR NM_005957.4(MTHFR): c.*2805A> G single nucleotide variant Uncertain significance rs116698217 GRCh37 Chromosome 1, 11847932: 11847932
43 MTHFR NM_005957.4(MTHFR): c.*2805A> G single nucleotide variant Uncertain significance rs116698217 GRCh38 Chromosome 1, 11787875: 11787875
44 MTHFR NM_005957.4(MTHFR): c.*2653C> T single nucleotide variant Uncertain significance rs564466007 GRCh37 Chromosome 1, 11848084: 11848084
45 MTHFR NM_005957.4(MTHFR): c.*2653C> T single nucleotide variant Uncertain significance rs564466007 GRCh38 Chromosome 1, 11788027: 11788027
46 MTHFR NM_005957.4(MTHFR): c.*2598C> T single nucleotide variant Likely benign rs11559040 GRCh37 Chromosome 1, 11848139: 11848139
47 MTHFR NM_005957.4(MTHFR): c.*2598C> T single nucleotide variant Likely benign rs11559040 GRCh38 Chromosome 1, 11788082: 11788082
48 MTHFR NM_005957.4(MTHFR): c.*2553G> A single nucleotide variant Uncertain significance rs539472116 GRCh38 Chromosome 1, 11788127: 11788127
49 MTHFR NM_005957.4(MTHFR): c.*2553G> A single nucleotide variant Uncertain significance rs539472116 GRCh37 Chromosome 1, 11848184: 11848184
50 MTHFR NM_005957.4(MTHFR): c.*2222C> T single nucleotide variant Uncertain significance rs886045181 GRCh38 Chromosome 1, 11788458: 11788458

Expression for Neural Tube Defects, Folate-Sensitive

Search GEO for disease gene expression data for Neural Tube Defects, Folate-Sensitive.

Pathways for Neural Tube Defects, Folate-Sensitive

Pathways related to Neural Tube Defects, Folate-Sensitive according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 MTHFD1 MTHFR MTR MTRR
2
Show member pathways
11.59 MTHFD1 MTHFR MTR MTRR
3
Show member pathways
11.49 MTR MTRR
4
Show member pathways
11.34 MTR MTRR
5
Show member pathways
11.07 MTHFD1 MTHFR MTR MTRR
6 10.64 MTR MTRR
7
Show member pathways
9.76 MTR MTRR

GO Terms for Neural Tube Defects, Folate-Sensitive

Biological processes related to Neural Tube Defects, Folate-Sensitive according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neural tube closure GO:0001843 9.46 MTHFD1 MTHFR
2 one-carbon metabolic process GO:0006730 9.43 MTHFD1 MTHFR
3 cellular amino acid biosynthetic process GO:0008652 9.43 MTHFD1 MTR MTRR
4 cobalamin metabolic process GO:0009235 9.4 MTR MTRR
5 tetrahydrofolate interconversion GO:0035999 9.37 MTHFD1 MTHFR
6 folic acid metabolic process GO:0046655 9.33 MTHFD1 MTHFR MTRR
7 homocysteine metabolic process GO:0050667 9.32 MTHFR MTRR
8 methionine metabolic process GO:0006555 9.13 MTHFD1 MTHFR MTRR
9 methionine biosynthetic process GO:0009086 8.92 MTHFD1 MTHFR MTR MTRR

Molecular functions related to Neural Tube Defects, Folate-Sensitive according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.43 MTHFD1 MTHFR MTRR
2 flavin adenine dinucleotide binding GO:0050660 9.16 MTHFR MTRR
3 NADP binding GO:0050661 8.96 MTHFR MTRR
4 FAD binding GO:0071949 8.62 MTHFR MTRR

Sources for Neural Tube Defects, Folate-Sensitive

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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44 MeSH
45 MESH via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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