Aliases & Classifications for Neuritis

MalaCards integrated aliases for Neuritis:

Name: Neuritis 12 55 44 15 72
Peripheral Neuritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1803
MeSH 44 D009443
NCIt 50 C116381
SNOMED-CT 68 84299009
UMLS 72 C0027813

Summaries for Neuritis

MalaCards based summary : Neuritis, also known as peripheral neuritis, is related to autoimmune optic neuritis and neuromyelitis optica, and has symptoms including sciatica and neuralgia. An important gene associated with Neuritis is PMP2 (Peripheral Myelin Protein 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Bevacizumab and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and brain, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 75 Neuritis (/njESETE^raEatEas/) is inflammation of a nerve or the general inflammation of the peripheral... more...

Related Diseases for Neuritis

Diseases related to Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 859)
# Related Disease Score Top Affiliating Genes
1 autoimmune optic neuritis 34.0 MOG MBP AQP4
2 neuromyelitis optica 33.4 MOG MBP AQP4
3 optic neuritis 33.2 TNF MT-ND4 MPZ MOG MBP MAG
4 optic nerve disease 32.3 MT-ND5 MT-ND4 MOG MBP AQP4
5 allergic encephalomyelitis 31.8 MOG MBP
6 neuropathy 31.2 PMP22 MT-ND5 MT-ND4 MPZ
7 transverse myelitis 31.1 TNF MBP AQP4
8 myelitis 31.0 TNF MOG MBP AQP4
9 guillain-barre syndrome 30.8 TNF PMP22 PMP2 MPZ MBP
10 kearns-sayre syndrome 30.8 MT-ND5 MT-ND4 MAG
11 miller fisher syndrome 30.7 TNF MAG
12 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 PMP22 MPZ IFNG
13 polyneuropathy 30.5 PMP22 MPZ MBP MAG
14 sarcoidosis 1 30.4 TNF IL1B IFNG
15 acquired immunodeficiency syndrome 30.4 TNF IL1B IFNG
16 internuclear ophthalmoplegia 30.3 MOG MBP AQP4
17 aseptic meningitis 30.2 TNF IL1B IFNG
18 sensory peripheral neuropathy 30.2 PMP22 MPZ MAG
19 osteomyelitis 30.2 TNF IL1B IFNG
20 typhoid fever 30.1 TNF IL1B IFNG
21 foot drop 30.1 PMP22 MPZ
22 poliomyelitis 30.1 TNF IL4 IFNG
23 secondary progressive multiple sclerosis 30.1 MBP IFNG CCL2
24 rubella 30.1 TNF MOG IL4
25 meningitis 30.0 TNF IL1B IFNG CCL2
26 acute disseminated encephalomyelitis 30.0 MPZ MOG MBP IL1B AQP4
27 intracranial hypertension 30.0 TNF IL1B AQP4
28 primary progressive multiple sclerosis 29.9 TNF MOG MBP
29 crohn's colitis 29.9 TNF IL1B IFNG
30 ulcerative colitis 29.9 TNF IL1B IFNG
31 rheumatic disease 29.9 TNF IL1B IFNG
32 lymphadenitis 29.8 TNF IL1B IFNG
33 miliary tuberculosis 29.8 TNF IFNG
34 brucellosis 29.7 TNF IL4 IFNG
35 uveitis 29.7 TNF IL4 IFNG CCL2
36 myasthenia gravis 29.7 TNF MBP IL4 IFNG
37 arthritis 29.6 TNF IL1B IFNG CCL2
38 monocytic leukemia 29.6 TNF IL1B IFNG
39 viral meningitis 29.6 IFNG CCL5 CCL2
40 polyradiculoneuropathy 29.5 PMP22 PMP2 MPZ MBP MAG IFNG
41 human immunodeficiency virus infectious disease 29.5 TNF IFNG CCL5
42 keratoconjunctivitis 29.4 TNF IL4 IFNG
43 spondyloarthropathy 29.4 TNF IL4 IFNG
44 campylobacteriosis 29.4 IL1B IFNG
45 aspergillosis 29.4 TNF IL4 IFNG
46 dengue shock syndrome 29.4 TNF IL1B CCL2
47 allergic hypersensitivity disease 29.4 IL4 IFNG CCL5
48 chorioamnionitis 29.3 TNF IL1B CCL2
49 mycobacterium tuberculosis 1 29.3 TNF IL4 IFNG
50 scleritis 29.3 TNF IL4 IFNG

Graphical network of the top 20 diseases related to Neuritis:



Diseases related to Neuritis

Symptoms & Phenotypes for Neuritis

UMLS symptoms related to Neuritis:


sciatica, neuralgia

MGI Mouse Phenotypes related to Neuritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 AQP4 IFNG MAG MBP MOG MPZ
2 hematopoietic system MP:0005397 10.02 AQP4 CCL5 IFNG IL1B IL4 MAG
3 homeostasis/metabolism MP:0005376 9.96 AQP4 IFNG IL1B IL4 MAG MBP
4 immune system MP:0005387 9.9 AQP4 CCL2 CCL5 IFNG IL1B IL4
5 nervous system MP:0003631 9.7 AQP4 IFNG IL1B IL4 MAG MBP
6 vision/eye MP:0005391 9.17 AQP4 IFNG IL4 MBP MOG PMP22

Drugs & Therapeutics for Neuritis

Drugs for Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Levodopa Approved Phase 4 59-92-7 6047
4
Carbidopa Approved Phase 4 28860-95-9 34359
5
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
10
4-Aminopyridine Approved Phase 4 504-24-5 1727
11
Idebenone Approved, Investigational Phase 4 58186-27-9
12
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
13
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
14
Choline Approved, Nutraceutical Phase 4 62-49-7 305
15 Raltegravir Potassium Phase 4
16 Integrase Inhibitors Phase 4
17 HIV Integrase Inhibitors Phase 4
18 Anti-HIV Agents Phase 4
19 Anti-Retroviral Agents Phase 4
20 (T,G)-A-L Phase 4
21
Glatiramer Acetate Phase 4 147245-92-9 3081884
22 HIV Protease Inhibitors Phase 4
23
protease inhibitors Phase 4
24 Angiogenesis Inhibitors Phase 4
25 Angiogenesis Modulating Agents Phase 4
26 Dopamine Agents Phase 4
27 Antiparkinson Agents Phase 4
28 Dopamine agonists Phase 4
29 Aromatic Amino Acid Decarboxylase Inhibitors Phase 4
30 Carbidopa, levodopa drug combination Phase 4
31 Central Nervous System Depressants Phase 4
32 Anesthetics Phase 4
33 Cholinergic Agents Phase 4
34 Acetylcholine Release Inhibitors Phase 4
35 Botulinum Toxins Phase 4
36 Nootropic Agents Phase 4
37 Cytidine Diphosphate Choline Phase 4
38 Anesthetics, Local Phase 4
39 BB 1101 Phase 4
40 Potassium Channel Blockers Phase 4
41 Antioxidants Phase 4
42 Respiratory System Agents Phase 4
43 Anti-Asthmatic Agents Phase 4
44 Betamethasone Valerate Phase 4 2152-44-5
45 Betamethasone sodium phosphate Phase 4
46 Betamethasone-17,21-dipropionate Phase 4
47 Betamethasone benzoate Phase 4
48 Adrenocorticotropic Hormone Phase 4
49 Melanocyte-Stimulating Hormones Phase 4
50 beta-endorphin Phase 4

Interventional clinical trials:

(show top 50) (show all 217)
# Name Status NCT ID Phase Drugs
1 An Open Pilot Study to Evaluate the Efficacy and Safety, Tolerability of Raltegravir(RAL)in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
2 A Multicenter Longitudinal Cross-sectional Pilot Study, to Compare RNFL Thickness Measured by OCT After Treatment With Glatiramer or After no Treatment in Patients With CIS With or Without Optic Neuritis or With Early RRMS Unknown status NCT00910598 Phase 4 glatiramer acetate
3 Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans Completed NCT00312325 Phase 4 Prednisolone
4 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
5 Controlled High-risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS10) Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
6 Dalfampridine Treatment for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
7 Probe Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
8 Combination of Dexamethasone and Bupivacaine Versus Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Intraoperative and Postoperative Analgesia in Patients Undergoing Lower Limb Vascular Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
9 Phase 4 Study of Evaluation of Neural Conduction Along the Visual Pathways Before and After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
10 Use of Bevacizumab in Trabeculectomy Surgery. A Prospective, 2 Centre, Randomized, Controlled Trial Completed NCT01166594 Phase 4 Bevacizumab;Control
11 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) : Pattern Electroretinography Study Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
12 Post-lesion Administration of Dexamethasone to Prevent the Development of Neuritis After Radiofrequency Ablation Recruiting NCT03247413 Phase 4 Dexamethasone 4 mg/ml;Normal saline
13 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Recruiting NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV methylprednisolone (steroids)
14 Short and Long Term Fampridine Treatment in Persons With Multiple Sclerosis: Cognitive and Motor Performances Recruiting NCT02849782 Phase 4 Fampridine
15 External Natural History Controlled, Open-Label Intervention Study to Assess the Efficacy and Safety of Long-Term Treatment With Raxone® in Leber's Hereditary Optic Neuropathy (LHON) Active, not recruiting NCT02774005 Phase 4 Idebenone
16 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Suspended NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
17 Prospective Case Crossover Study to Assess Whether PDE5 Inhibitor Exposure in Men Increases the Risk for the Development of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
18 Modeling and Treating the Pathophysiology of Demyelination in Multiple Sclerosis Terminated NCT00854750 Phase 4 ACTHAR;ACTHAR;ACTHAR;ACTHAR
19 Optical Coherence Tomography as a Measure of Neuroprotection in Patients With Relapsing-Remitting Multiple Sclerosis Receiving Natalizumab or Interferon Beta-1a Withdrawn NCT00771043 Phase 4 TYSABRI and AVONEX
20 An Open Label Pilot Study of Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event: Comparison With CHAMPS Results. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
21 Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: a Pivotal Randomized Double Masked Placebo Controlled Study Unknown status NCT02220244 Phase 3 MD1003 100mg capsule
22 Simvastatin Treatment of Patients With Acut Optic Neuritis. A Doubleblind, Randomized and Placebo Controlled Fase III Trial Unknown status NCT00261326 Phase 3 simvastatin;placebo
23 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
24 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of Nonarteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
25 The Effect of High Dose Steroid and Normobaric Oxygen Therapy on Recent Onset Non-arteritic Anterior Ischemic Optic Neuropathy(NAION); a Randomized Clinical Trial Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
26 A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON) Completed NCT00856635 Phase 3 Glatiramer Acetate;placebo
27 The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study Completed NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
28 Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis Completed NCT01337986 Phase 2, Phase 3 Dalfampridine/Placebo;Placebo/Dalfampridine
29 Recovery of Demyelinating Optic Neuritis After Treatment With Equivalent High Doses of Oral vs. Intravenous Corticosteroids: a Randomized Single Blinded Clinical Trial Completed NCT01524250 Phase 2, Phase 3 corticosteroids;corticosteroids
30 A Randomized, Double-Blind, Placebo Controlled, Cross-over Study of the Effectiveness of Immune Globulin Intravenous (Human), 10% (IGIV, 10%) for the Treatment of Multifocal Motor Neuropathy Completed NCT00666263 Phase 3
31 Intravenous Immunoglobulin Therapy in Optic Neuritis Completed NCT00000117 Phase 3 Immunoglobulin
32 NPB-01(Intravenous Immunoglobulin) Maintenance Therapy for Patients With Multifocal Motor Neuropathy. Completed NCT01827072 Phase 3 NPB-01
33 Paraorbital-occipital Alternating Electric Current Stimulation in Patients With Optic Neuropathy Completed NCT01282827 Phase 2, Phase 3
34 A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) Completed NCT00528151 Phase 3 curcumin
35 Comparison of Annual Relapse Rate, Expanded Disability Status Scale, and Side Effects Between Azathioprine and Rituximab in Patients With Neuromyelitis Optica Spectrum Disorders Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
36 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
37 Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
38 Effects of Dalfampridine on Cognition in Multiple Sclerosis Completed NCT02006160 Phase 2, Phase 3 dalfampridine;placebo
39 A Double-Masked Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Participants With Previous NAION Recruiting NCT03547206 Phase 3 RPh201
40 Traumatic Optic Neuropathy Treatment Trial 2; Efficacy of Different Doses of Erythropoietin. A Multicenter, Double Blind RCT Recruiting NCT03308448 Phase 3 Recombinant human erythropoietin
41 Effect of Bosentan in Patients With Non Arteritic Ischemic Optic Neuropathy Recruiting NCT02377271 Phase 3 bosentan;placebo
42 Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial Active, not recruiting NCT01962571 Phase 3 Erythropoietin alfa;Placebo
43 A Phase III, Open-label, Extension Trial of ECU-NMO-301 to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Active, not recruiting NCT02003144 Phase 3
44 Erythropoietin in Methanol Associated Optic Neuropathy Active, not recruiting NCT02376881 Phase 3 Erythropoietin
45 Efficacy and Safety of Bilateral Intravitreal Injection of GS010: A Randomized, Double-Masked, Placebo-Controlled Trial in Subjects Affected With G11778A ND4 Leber Hereditary Optic Neuropathy for Up to One Year Active, not recruiting NCT03293524 Phase 3 Placebo
46 Safety and Efficacy Study of Gene Therapy for The Treatment of Leber's Hereditary Optic Neuropathy Active, not recruiting NCT03153293 Phase 2, Phase 3 rAAV2-ND4
47 Phase II/III Study to Investigate the Effects of Fingolimod Versus Interferon Beta-1b on Visual Recovery After Optic Neuritis Terminated NCT01647880 Phase 2, Phase 3 Verum arm receiving Gilenya®;Active Comparator receiving Extavia®
48 A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Terminated NCT01892345 Phase 3 Eculizumab;Placebo
49 A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 Delivered By Single or Multi-Dose Intravitreal Injection(s) to Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg
50 Study With Idebenone in Patients With Chronic Vision Loss Due to Leber's Hereditary Optic Neuropathy (LHON) Withdrawn NCT01495715 Phase 3 Idebenone;Placebo

Search NIH Clinical Center for Neuritis

Cochrane evidence based reviews: neuritis

Genetic Tests for Neuritis

Anatomical Context for Neuritis

MalaCards organs/tissues related to Neuritis:

41
Testes, Eye, Brain, T Cells, Bone, Spinal Cord, Retina

Publications for Neuritis

Articles related to Neuritis:

(show top 50) (show all 9737)
# Title Authors PMID Year
1
Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. 9 38
18577885 2008
2
Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease. 9 38
16753180 2006
3
Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy. 9 38
16519780 2006
4
Guillain-Barré syndrome. 9 38
16271648 2005
5
Sequential expression of chemokines in experimental autoimmune neuritis. 9 38
11024541 2000
6
Pathogenesis of Guillain-Barré syndrome. 9 38
10695718 1999
7
Induction of experimental autoimmune neuritis with peripheral myelin protein-22. 9 38
9798745 1998
8
Clomipramine and imipramine suppress clinical signs and T and B cell response to myelin proteins in experimental autoimmune neuritis in Lewis rats. 9 38
9776709 1998
9
Effect of lipids on the conformation of an antigenic determinant for experimental autoimmune neuritis. 9 38
9584990 1998
10
Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. 9 38
9037054 1997
11
The antibody repertoire in experimental allergic neuritis: evidence for PMP-22 as a novel neuritogen. 9 38
8982118 1996
12
Conformation of an antigenic determinant for experimental autoimmune neuritis. 9 38
8694832 1996
13
Human peripheral myelin protein-22 carries the L2/HNK-1 carbohydrate adhesion epitope. 9 38
7693873 1993
14
Pathogenesis of immune-mediated neuropathies. 9 38
8381954 1993
15
Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis. 9 38
1381167 1992
16
[Immunoregulation disturbance in experimental allergic neuritis. The cellular and humoral mediated immunological damage]. 9 38
1711438 1990
17
Macrophages but not Schwann cells express Ia antigen in experimental autoimmune neuritis. 9 38
2375636 1990
18
The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases. 38
31397331 2019
19
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 38
31070081 2019
20
A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis. 38
30784250 2019
21
Why and when to refer patients for vestibular evoked myogenic potentials: A critical review. 38
31299589 2019
22
Aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in immune-mediated optic neuritis at long-term follow-up. 38
31118222 2019
23
Inflammatory Reaction Secondary to Immune Checkpoint Inhibitor Therapy Mimicking a Post-Operative Brain Abscess. 38
31203078 2019
24
Eyes are mirror of the brain: comparison of multiple sclerosis patients and healthy controls using OCT. 38
30696321 2019
25
Mean platelet volume, neutrophil- and platelet to lymphocyte ratios are elevated in vestibular neuritis. 38
31202637 2019
26
Protective effect of ISO‑1 against advanced glycation end product aggravation of PC12 cell injury induced by Aβ1‑40. 38
31322215 2019
27
Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma. 38
30531633 2019
28
Optical Coherence Tomography Angiography of a Pale Optic Disc in Demyelinating Optic Neuritis and Ischemic Optic Neuropathy. 38
30893268 2019
29
The Interrelations Between Different Causes of Dizziness: A Conceptual Framework for Understanding Vestibular Disorders. 38
31018648 2019
30
Feline Ocular Mycobacteriosis: Clinical Presentation, Histopathological Features, and Outcome. 38
31132943 2019
31
Nerve Ultrasonography as an Additive Tool to Clinical Examination and Electrodiagnostics in Sporadic Mononeuritis - Imaging is the Key. 38
31238384 2019
32
Retinal and optic nerve degeneration in liver X receptor β knockout mice. 38
31371497 2019
33
Efficacy and safety of fractionated conformal radiation therapy in acromegaly: a long-term follow-up study. 38
31098940 2019
34
Ultrasound and optic neuritis. 38
30744912 2019
35
Update on pediatric optic neuritis. 38
31433309 2019
36
Optic Neuritis In the Era of Biomarkers. 38
31425702 2019
37
Ultrasound optic nerve sheath diameter measurement in optic neuritis. 38
30683469 2019
38
A new association: acute macular neuroretinopathy in acute optic neuritis. 38
30761755 2019
39
Acute Optic Neuritis Diagnosed by Bedside Ultrasound in an Emergency Department. 38
31229301 2019
40
The clinical spectrum and prognosis of idiopathic acute optic neuritis: A longitudinal study in Southern Finland. 38
31401426 2019
41
Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis. 38
31406150 2019
42
MRI of acute optic neuritis (ON) at the first episode: Can we predict the visual outcome and the development of multiple sclerosis (MS)? 38
31435862 2019
43
Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event. 38
31432354 2019
44
The swollen optic nerve: an approach to diagnosis and management. 38
31196885 2019
45
Linezolid interruption in patients with fluoroquinolone-resistant tuberculosis receiving a bedaquiline-based treatment regimen. 38
31100421 2019
46
Subclinical neurodegeneration in multiple sclerosis and neuromyelitis optica spectrum disorder revealed by optical coherence tomography. 38
31392924 2019
47
Uveitis and optic perineuritis in the context of myelin oligodendrocyte glycoprotein antibody seropositivity. 38
30748058 2019
48
Isoniazid-induced neuropathy in a pre-pubertal child. 38
29897291 2019
49
Apelin-13 regulates LPS-induced N9 microglia polarization involving STAT3 signaling pathway. 38
31255353 2019
50
Sonographic appearance of flexor carpi radialis tenosynovitis associated with a neuritis of the palmar cutaneous branch of the median nerve. 38
31049976 2019

Variations for Neuritis

Expression for Neuritis

Search GEO for disease gene expression data for Neuritis.

Pathways for Neuritis

Pathways related to Neuritis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.28 TNF IL4 IL1B IFNG CCL5 CCL2
2
Show member pathways
13.01 TNF IL1B IFNG CCL5 CCL2
3
Show member pathways
12.52 TNF IL4 IL1B IFNG
4
Show member pathways
12.51 TNF IL1B IFNG CCL2
5
Show member pathways
12.5 TNF IL4 IL1B IFNG
6 12.49 TNF IL4 IL1B IFNG CCL5 CCL2
7
Show member pathways
12.27 TNF IL4 IL1B IFNG CCL2
8
Show member pathways
12.2 TNF IL4 IL1B IFNG
9
Show member pathways
12.19 TNF IL4 IL1B IFNG
10
Show member pathways
12.18 TNF IL4 IL1B IFNG CCL5 CCL2
11
Show member pathways
12.13 TNF IL4 IL1B IFNG
12 12.04 TNF IL1B IFNG CCL2
13
Show member pathways
12.02 IL4 IL1B IFNG CCL5 CCL2
14
Show member pathways
11.99 TNF IL1B IFNG
15
Show member pathways
11.99 TNF IL4 IL1B IFNG
16 11.98 TNF IL1B IFNG
17 11.93 TNF IL4 IFNG
18 11.93 TNF IL4 IL1B CCL2
19 11.92 TNF IL1B CCL5 CCL2
20
Show member pathways
11.9 IL4 IL1B IFNG
21 11.85 PMP22 MPZ MBP
22 11.84 TNF IL1B CCL2
23 11.84 TNF IL1B IFNG
24 11.83 TNF IL4 IL1B
25 11.75 TNF IL4 IL1B IFNG
26
Show member pathways
11.7 TNF IL4 IFNG
27 11.69 TNF IL1B IFNG
28 11.69 TNF IL1B IFNG CCL5 CCL2
29
Show member pathways
11.61 TNF IL1B IFNG
30 11.48 TNF IL1B IFNG
31 11.47 TNF IL1B IFNG CCL2
32 11.45 TNF IL1B IFNG
33 11.45 TNF IL4 IL1B CCL5 CCL2
34 11.44 TNF IL1B IFNG CCL2
35 11.34 TNF IL1B IFNG
36 11.3 TNF MBP MAG IL4 IL1B IFNG
37 11.28 TNF IL4 IL1B IFNG CCL5 CCL2
38 11.24 TNF IL4 IL1B IFNG
39 11.24 TNF IL4 IL1B CCL5 CCL2
40 11.17 TNF IL4 IL1B IFNG
41 11.14 TNF IL4 IL1B CCL5 CCL2
42 11.13 IL1B IFNG CCL2
43 10.95 TNF IL4 IL1B CCL5 CCL2
44 10.9 TNF IL1B CCL2
45 10.54 MBP MAG

GO Terms for Neuritis

Cellular components related to Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 9.26 PMP2 MPZ MBP MAG
2 compact myelin GO:0043218 8.8 PMP22 MBP MAG

Biological processes related to Neuritis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.96 TNF IL1B CCL5 CCL2
2 cytokine-mediated signaling pathway GO:0019221 9.85 TNF IL4 IL1B CCL5 CCL2
3 MAPK cascade GO:0000165 9.83 TNF MBP IL1B CCL5 CCL2
4 response to virus GO:0009615 9.82 TNF IFNG CCL5
5 cellular response to interferon-gamma GO:0071346 9.81 CCL5 CCL2 AQP4
6 immune response GO:0006955 9.8 TNF MBP IL4 IL1B IFNG CCL5
7 neutrophil chemotaxis GO:0030593 9.79 IL1B CCL5 CCL2
8 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.79 TNF CCL5 CCL2
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IL4 IFNG CCL5
10 positive regulation of T cell proliferation GO:0042102 9.75 IL4 IL1B CCL5
11 humoral immune response GO:0006959 9.73 TNF IFNG CCL2
12 myelination GO:0042552 9.71 PMP22 MPZ MBP
13 positive regulation of osteoclast differentiation GO:0045672 9.67 TNF IFNG
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 TNF IL1B IFNG
15 cellular response to organic cyclic compound GO:0071407 9.67 TNF IL1B CCL5 CCL2
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.66 TNF IL1B
17 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL1B
18 negative regulation of lipid catabolic process GO:0050995 9.65 TNF IL1B
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 TNF IL1B
20 macrophage chemotaxis GO:0048246 9.64 CCL5 CCL2
21 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.62 MPZ MAG
22 regulation of insulin secretion GO:0050796 9.62 TNF IL1B IFNG CCL5
23 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TNF IL1B
24 regulation of establishment of endothelial barrier GO:1903140 9.59 TNF IL1B
25 ATP synthesis coupled electron transport GO:0042773 9.58 MT-ND5 MT-ND4
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IL1B IFNG
27 positive regulation of neuroinflammatory response GO:0150078 9.57 TNF IL1B
28 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
29 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
30 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 TNF IFNG
31 protein kinase B signaling GO:0043491 9.46 TNF IL1B CCL5 CCL2
32 positive regulation of astrocyte differentiation GO:0048711 9.33 MAG
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.26 TNF IL1B CCL5 CCL2
34 chronic inflammatory response to antigenic stimulus GO:0002439 9.21 TNF
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL4 IL1B IFNG CCL5 CCL2
2 NADH dehydrogenase activity GO:0003954 8.96 MT-ND5 MT-ND4

Sources for Neuritis

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