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MCID: NRS002
MIFTS: 29

Neuroaspergillosis

Categories: Infectious diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Neuroaspergillosis

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MalaCards integrated aliases for Neuroaspergillosis:

Name: Neuroaspergillosis 12 44 15 17 71

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13565
MeSH 44 D020953
UMLS 71 C0752342
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Summaries for Neuroaspergillosis

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Disease Ontology : 12 An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

MalaCards based summary : Neuroaspergillosis is related to tinea profunda and neonatal candidiasis. An important gene associated with Neuroaspergillosis is DYRK3 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Affiliated tissues include brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Neuroaspergillosis

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Diseases related to Neuroaspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 tinea profunda 10.2 CLEC7A CARD9
2 neonatal candidiasis 10.2 CLEC7A CARD9
3 fusariosis 10.2 CYP51A1 CLEC7A
4 trichosporonosis 10.2 CLEC7A CARD9
5 penicilliosis 10.2 CLEC7A CARD9
6 dermatomycosis 10.2 CYP51A1 CLEC7A
7 tinea cruris 10.2 CYP51A1 CARD9
8 adenoiditis 10.2 CLEC7A CARD9
9 tinea capitis 10.2 CLEC7A CARD9
10 esophageal tuberculosis 10.2 NFKB1 LRBA
11 phaeohyphomycosis 10.2 CYP51A1 CLEC7A CARD9
12 esophageal candidiasis 10.2 CYP51A1 CLEC7A CARD9
13 candidiasis 10.2 CYP51A1 CLEC7A CARD9
14 cutaneous candidiasis 10.2 CLEC7A CARD9
15 tinea pedis 10.2 CYP51A1 CLEC7A CARD9
16 aspergillosis 10.2
17 dermatophytosis 10.2 CYP51A1 CLEC7A CARD9
18 mucormycosis 10.1 CYP51A1 CLEC7A CARD9
19 coccidioidomycosis 10.1 CYP51A1 CLEC7A CARD9
20 primary systemic mycosis 10.1 CYP51A1 CLEC7A CARD9
21 tinea corporis 10.1 CLEC7A CARD9
22 opportunistic mycosis 10.1 CYP51A1 CLEC7A CARD9
23 fungal infectious disease 10.1 CYP51A1 CLEC7A CARD9
24 subcutaneous mycosis 10.1 CLEC7A CARD9
25 blastomycosis 10.1 CLEC7A CARD9
26 sveinsson chorioretinal atrophy 10.1 YAP1 LRBA CYP51A1
27 sporotrichosis 10.1 CLEC7A CARD9
28 haemophilus influenzae 9.9 VTN CLEC7A
29 myeloma, multiple 9.9
30 yemenite deaf-blind hypopigmentation syndrome 9.9
31 leukemia, acute lymphoblastic 9.9
32 chronic granulomatous disease 9.9
33 chromoblastomycosis 9.9 CLEC7A CARD9
34 asbestos-related lung carcinoma 9.9 PRKCA NFKB2
35 common variable immunodeficiency 9.8 NFKB2 NFKB1 LRBA ADA
36 amyotrophic lateral sclerosis 1 8.9 VTN TRIM21 LRBA HSP90B1 CYP51A1 CLEC7A

Graphical network of the top 20 diseases related to Neuroaspergillosis:



Diseases related to Neuroaspergillosis
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Symptoms & Phenotypes for Neuroaspergillosis

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GenomeRNAi Phenotypes related to Neuroaspergillosis according to GeneCards Suite gene sharing:

26 (show top 50) (show all 59)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 10.07 CLEC7A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.07 CLEC7A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 10.07 YAP1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 10.07 CLEC7A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 10.07 HSP90B1 YAP1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 10.07 CLEC7A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 10.07 CLEC7A CYP51A1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 10.07 CLEC7A YAP1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.07 CLEC7A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.07 YAP1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-194 10.07 YAP1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.07 CLEC7A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 10.07 CLEC7A
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 10.07 CLEC7A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 10.07 CYP51A1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.07 CLEC7A
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-37 10.07 YAP1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.07 YAP1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.07 YAP1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.07 CLEC7A
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 10.07 CLEC7A
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 10.07 CLEC7A CYP51A1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.92 PIK3R1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.92 CYP51A1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.92 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.92 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.92 CLEC7A
28 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.92 CLEC7A
29 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.92 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.92 CARD9
31 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.92 CLEC7A
32 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.92 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.92 HSP90B1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.92 CLEC7A
35 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.92 CYP51A1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.92 CLEC7A
37 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.92 PIK3R1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.92 CLEC7A
39 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.92 HSP90B1
40 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.92 CARD9
41 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.92 CLEC7A
42 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.92 HSP90B1
43 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.92 HSP90B1
44 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.92 CARD9
45 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.92 PIK3R1
46 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.92 CYP51A1
47 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.92 CLEC7A CYP51A1 HSP90B1 PIK3R1
48 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.92 CARD9
49 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.92 CLEC7A
50 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.92 PIK3R1

MGI Mouse Phenotypes related to Neuroaspergillosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 ABCB4 ADA CARD9 CLEC7A DYRK3 FBN1
2 homeostasis/metabolism MP:0005376 10.03 ABCB4 ADA CARD9 CLEC7A CYP51A1 FBN1
3 digestive/alimentary MP:0005381 9.92 ABCB4 ADA CLEC7A CYP51A1 LRBA NFKB1
4 immune system MP:0005387 9.8 ABCB4 ADA CARD9 CLEC7A CYP51A1 FBN1
5 muscle MP:0005369 9.17 ADA CYP51A1 FBN1 NFKB1 PIK3R1 PRKCA
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Drugs & Therapeutics for Neuroaspergillosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized Trial Comparing The Safety, Tolerability, And Efficacy Of Voriconazole And Anidulafungin In Combination To That Of Voriconazole Alone When Used For Primary Therapy Of Invasive Aspergillosis in Pediatric Subjects Aged 2 to 17 Years Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole

Search NIH Clinical Center for Neuroaspergillosis

Cochrane evidence based reviews: neuroaspergillosis

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Genetic Tests for Neuroaspergillosis

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Anatomical Context for Neuroaspergillosis

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MalaCards organs/tissues related to Neuroaspergillosis:

40
Brain
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Publications for Neuroaspergillosis

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Articles related to Neuroaspergillosis:

# Title Authors PMID Year
1
Neuroaspergillosis as the Presenting Sign of a Chronic Granulomatous Disease. 61
31570298 2020
2
Aspergillosis after liver transplantation in the context of common variable immunodeficiency: case report. 61
23676145 2013
3
Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis. 61
23448824 2013
4
Neuroaspergillosis leading to blindness in a patient with multiple myeloma. 61
19884809 2010
5
[Successful treatment of neuroaspergillosis in a patient with acute lymphoblastic leukemia: role of surgery, systemic antifungal therapy and intracavitary therapy]. 61
19795628 2009
6
Cerebral aspergillosis: tissue penetration is the key. 61
19255905 2009
7
Neuroaspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid. 61
19602790 2009
8
Neuroaspergillosis in an immunocompetent patient. 61
17377359 2007
9
Neuroaspergillosis and brain tuberculosis in an immunocompetent patient with good outcome. 61
9527169 1998
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Variations for Neuroaspergillosis

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Expression for Neuroaspergillosis

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Search GEO for disease gene expression data for Neuroaspergillosis.
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Pathways for Neuroaspergillosis

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Pathways related to Neuroaspergillosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.87 VTN PRKCA PIK3R1 NFKB1 HSP90B1
2
Pathways in cancer 36
12.63 PRKCA PIK3R1 NFKB2 NFKB1 HSP90B1
3
Immune response IL-23 signaling pathway 23
Show member pathways
 12.46 YAP1 PIK3R1 NFKB2 NFKB1
4
Immune response Fc epsilon RI pathway 23
Show member pathways
 12.46 PRKCA PIK3R1 NFKB2 NFKB1
5
B Cell Receptor Signaling Pathway (sino) 66
Show member pathways
 12.29 PRKCA PIK3R1 NFKB2 NFKB1
6
VEGF Pathway (Qiagen) 63
Show member pathways
 12.28 VTN PRKCA PIK3R1 NFKB1
7
Apoptosis Pathway 70
Show member pathways
 12.27 PRKCA PIK3R1 NFKB2 NFKB1
8
CLEC7A (Dectin-1) signaling 65
Show member pathways
 12.24 NFKB2 NFKB1 CLEC7A CARD9
9
Development IGF-1 receptor signaling 23
Show member pathways
 12.16 PIK3R1 NFKB2 NFKB1 HSP90B1
10
Development ERBB-family signaling 23
Show member pathways
 12.1 PRKCA PIK3R1 NFKB2 NFKB1
11
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 12.04 PRKCA PIK3R1 NFKB2 NFKB1 HSP90B1
12
DNA Damage Response (only ATM dependent) 1
11.85 PIK3R1 NFKB2 NFKB1
13
HIF-1 signaling pathway 36
11.82 PRKCA PIK3R1 NFKB1
14
Amoebiasis 36
11.78 PRKCA PIK3R1 NFKB1
15
AGE-RAGE signaling pathway in diabetic complications 36
11.77 PRKCA PIK3R1 NFKB1
16
Sphingolipid signaling pathway 36
11.74 SMPD2 PRKCA PIK3R1 NFKB1
17
TGF-beta Signaling Pathways 64
11.73 PIK3R1 NFKB2 NFKB1
18
Inhibitory action of Lipoxins on Superoxide production in neutrophils 23
Show member pathways
 11.71 PRKCA NFKB2 NFKB1
19
LT-BetaR Pathway 63
Show member pathways
 11.59 PIK3R1 NFKB2 NFKB1
20
C-type lectin receptor signaling pathway 36
Show member pathways
 11.59 PIK3R1 NFKB2 NFKB1 CLEC7A CARD9
21
Phagocytosis of Microbes 63
11.39 VTN PRKCA PIK3R1 CLEC7A
22
IL-2 Gene Expression in Activated and Quiescent T-Cells 63
Show member pathways
 11.31 PRKCA PIK3R1 NFKB2 NFKB1
23
Development_Glucocorticoid receptor signaling 23
11.19 NFKB2 NFKB1 HSP90B1
24
MAPK Pathway 70
Show member pathways
 11.11 PRKCA PIK3R1 NFKB2 NFKB1 HSP90B1
25
Telomere Extension by Telomerase 63
Show member pathways
 11.03 PIK3R1 NFKB2 NFKB1
26
Atypical NF-kappaB pathway 1
10.73 PIK3R1 NFKB1
27
Interleukin-1 processing 65
10.3 NFKB2 NFKB1
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GO Terms for Neuroaspergillosis

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Cellular components related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.4 YAP1 TRIM21 PRKCA PIK3R1 NFKB2 NFKB1

Biological processes related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trophectodermal cell differentiation GO:0001829 9.16 YAP1 ADA
2 positive regulation of tumor necrosis factor production GO:0032760 9.13 PIK3R1 CLEC7A CARD9
3 negative regulation of apoptotic process GO:0043066 9.02 PIK3R1 NFKB1 HSP90B1 DYRK3 ADA

Molecular functions related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 YAP1 VTN TRIM21 SMPD2 PRKCA PIK3R1
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Sources for Neuroaspergillosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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