Neuroaspergillosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Neuroaspergillosis

MalaCards integrated aliases for Neuroaspergillosis:

Name: Neuroaspergillosis ¹² ⁴³ ¹⁵ ¹⁷ ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13565

MeSH ⁴³ D020953

EFO ¹⁷ EFO_0007393

UMLS ⁷¹ C0752342

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Summaries for Neuroaspergillosis

Disease Ontology : ¹² An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

MalaCards based summary : Neuroaspergillosis is related to aspergillosis and tinea profunda. An important gene associated with Neuroaspergillosis is DYRK3 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway. Affiliated tissues include brain, liver and lymph node, and related phenotype is hematopoietic system.

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Related Diseases for Neuroaspergillosis

Diseases related to Neuroaspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	aspergillosis	10.4
2	tinea profunda	10.2	CLEC7A CARD9
3	cutaneous candidiasis	10.2	CLEC7A CARD9
4	penicilliosis	10.2	CLEC7A CARD9
5	phaeohyphomycosis	10.2	CLEC7A CARD9
6	tinea pedis	10.2	CLEC7A CARD9
7	myeloma, multiple	10.2
8	yemenite deaf-blind hypopigmentation syndrome	10.2
9	leukemia, acute lymphoblastic	10.2
10	lymphocytic leukemia	10.2
11	chronic granulomatous disease	10.2
12	rare surgical neurologic disease	10.2
13	subcutaneous mycosis	10.2	CLEC7A CARD9
14	blastomycosis	10.1	CLEC7A CARD9
15	sporotrichosis	10.1	CLEC7A CARD9
16	hyper ige recurrent infection syndrome 1	10.1	CLEC7A CARD9
17	chromoblastomycosis	10.1	CLEC7A CARD9
18	dermatophytosis	10.1	CLEC7A CARD9
19	mucormycosis	10.1	CLEC7A CARD9
20	coccidioidomycosis	10.1	CLEC7A CARD9
21	nail disease	10.0	CLEC7A CARD9
22	autoimmune polyendocrine syndrome type 1	10.0	CLEC7A CARD9
23	oral candidiasis	10.0	CLEC7A CARD9
24	amyotrophic lateral sclerosis 3	9.9	TRIM21 CLEC7A
25	fungal keratitis	9.8	TLR2 CLEC7A
26	mycobacterium abscessus	9.8	TLR2 CLEC7A
27	endophthalmitis	9.7	TLR2 CARD9
28	primary systemic mycosis	9.6	TLR2 CLEC7A CARD9
29	vulvovaginal candidiasis	9.6	TLR2 CLEC7A CARD9
30	candidiasis	9.6	TLR2 CLEC7A CARD9
31	vaginal disease	9.6	TLR2 CLEC7A CARD9
32	opportunistic mycosis	9.6	TLR2 CLEC7A CARD9
33	chronic mucocutaneous candidiasis	9.6	TLR2 CLEC7A CARD9
34	invasive aspergillosis	9.6	TLR2 CLEC7A
35	inflammatory bowel disease 1	9.5	TLR2 CARD9
36	interstitial lung disease	9.5	VTN TRIM21 CD44
37	haemophilus influenzae	9.4	VTN TLR2 CLEC7A
38	lymph node disease	9.2	TRIM21 TLR2
39	amyotrophic lateral sclerosis 1	8.4	VTN TRIM21 TLR2 HSP90B1 CLEC7A CARD9

Graphical network of the top 20 diseases related to Neuroaspergillosis:

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Symptoms & Phenotypes for Neuroaspergillosis

MGI Mouse Phenotypes related to Neuroaspergillosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.23	CARD9 CD44 CLEC7A DYRK3 HSP90B1 TLR2

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Drugs & Therapeutics for Neuroaspergillosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Prospective, Randomized Trial Comparing The Safety, Tolerability, And Efficacy Of Voriconazole And Anidulafungin In Combination To That Of Voriconazole Alone When Used For Primary Therapy Of Invasive Aspergillosis in Pediatric Subjects Aged 2 to 17 Years	Withdrawn	NCT01188759	Phase 3	Voriconazole;Anidulafungin;Voriconazole

Search NIH Clinical Center for Neuroaspergillosis

Cochrane evidence based reviews: neuroaspergillosis

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Genetic Tests for Neuroaspergillosis

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Anatomical Context for Neuroaspergillosis

MalaCards organs/tissues related to Neuroaspergillosis:

⁴⁰

Brain, Liver, Lymph Node, Lung

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Publications for Neuroaspergillosis

Articles related to Neuroaspergillosis:

#	Title	Authors	PMID	Year
1	Neuroaspergillosis as the Presenting Sign of a Chronic Granulomatous Disease. ⁶¹	Salomone G...Pratico AD	31570298	2020
2	Aspergillosis after liver transplantation in the context of common variable immunodeficiency: case report. ⁶¹	Chen Y...Cameron A	23676145	2013
3	Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis. ⁶¹	Soeffker G...Kluge S	23448824	2013
4	Neuroaspergillosis leading to blindness in a patient with multiple myeloma. ⁶¹	Butler S...Malone RJ	19884809	2010
5	[Successful treatment of neuroaspergillosis in a patient with acute lymphoblastic leukemia: role of surgery, systemic antifungal therapy and intracavitary therapy]. ⁶¹	Ozcelik T...Tunali A	19795628	2009
6	Cerebral aspergillosis: tissue penetration is the key. ⁶¹	Schwartz S...Thiel E	19255905	2009
7	Neuroaspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid. ⁶¹	Hiraga A...Kamitsukasa I	19602790	2009
8	Neuroaspergillosis in an immunocompetent patient. ⁶¹	Sood S...Rishi S	17377359	2007
9	Neuroaspergillosis and brain tuberculosis in an immunocompetent patient with good outcome. ⁶¹	Renard JE...Mihout B	9527169	1998

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Genes for Neuroaspergillosis

Genes related to Neuroaspergillosis (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DYRK3	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3	Protein Coding	6.03	DISEASES inferred ¹⁵
2	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	5.1	DISEASES inferred ¹⁵
3	LINC01554	Long Intergenic Non-Protein Coding RNA 1554	RNA Gene	5	DISEASES inferred ¹⁵
4	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	4.85	DISEASES inferred ¹⁵
5	PRKCA	Protein Kinase C Alpha	Protein Coding	4.68	DISEASES inferred ¹⁵
6	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	4.5	DISEASES inferred ¹⁵
7	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	4.47	DISEASES inferred ¹⁵
8	TRIM21	Tripartite Motif Containing 21	Protein Coding	4.29	DISEASES inferred ¹⁵
9	VTN	Vitronectin	Protein Coding	4.22	DISEASES inferred ¹⁵
10	TLR2	Toll Like Receptor 2	Protein Coding	3.29	DISEASES inferred ¹⁵
11	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	3.28	DISEASES inferred ¹⁵

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Variations for Neuroaspergillosis

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Expression for Neuroaspergillosis

Search GEO for disease gene expression data for Neuroaspergillosis.

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Pathways for Neuroaspergillosis

Pathways related to Neuroaspergillosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.45	VTN TRIM21 TLR2 PRKCA HSP90B1 CLEC7A
2	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.54	VTN TLR2 PRKCA HSP90B1
3	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁴	11.93	PRKCA HSP90B1 CD44
4	Tuberculosis ³⁶	11.75	TLR2 CLEC7A CARD9
5	Proteoglycans in cancer ³⁶	11.57	VTN TLR2 PRKCA CD44
6	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.43	TLR2 PRKCA HSP90B1
7	Phagocytosis of Microbes ⁶³	10.85	VTN TLR2 PRKCA CLEC7A

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GO Terms for Neuroaspergillosis

Biological processes related to Neuroaspergillosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	9.46	TRIM21 TLR2 CLEC7A CARD9
2	T cell activation	GO:0042110	9.32	CLEC7A CD44
3	toll-like receptor signaling pathway	GO:0002224	9.26	TLR2 HSP90B1
4	positive regulation of wound healing	GO:0090303	8.96	VTN CLEC7A
5	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043518	8.62	DYRK3 CD44

Molecular functions related to Neuroaspergillosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling pattern recognition receptor activity	GO:0008329	8.62	TLR2 CLEC7A

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