MCID: NRS002
MIFTS: 26

Neuroaspergillosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Neuroaspergillosis

MalaCards integrated aliases for Neuroaspergillosis:

Name: Neuroaspergillosis 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13565
MeSH 43 D020953
UMLS 71 C0752342

Summaries for Neuroaspergillosis

Disease Ontology : 12 An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

MalaCards based summary : Neuroaspergillosis is related to aspergillosis and tinea profunda. An important gene associated with Neuroaspergillosis is DYRK3 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 3), and among its related pathways/superpathways are Innate Immune System and PI3K-Akt signaling pathway. Affiliated tissues include brain, liver and lymph node, and related phenotype is hematopoietic system.

Related Diseases for Neuroaspergillosis

Diseases related to Neuroaspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 10.4
2 tinea profunda 10.2 CLEC7A CARD9
3 cutaneous candidiasis 10.2 CLEC7A CARD9
4 penicilliosis 10.2 CLEC7A CARD9
5 phaeohyphomycosis 10.2 CLEC7A CARD9
6 tinea pedis 10.2 CLEC7A CARD9
7 myeloma, multiple 10.2
8 yemenite deaf-blind hypopigmentation syndrome 10.2
9 leukemia, acute lymphoblastic 10.2
10 lymphocytic leukemia 10.2
11 chronic granulomatous disease 10.2
12 rare surgical neurologic disease 10.2
13 subcutaneous mycosis 10.2 CLEC7A CARD9
14 blastomycosis 10.1 CLEC7A CARD9
15 sporotrichosis 10.1 CLEC7A CARD9
16 hyper ige recurrent infection syndrome 1 10.1 CLEC7A CARD9
17 chromoblastomycosis 10.1 CLEC7A CARD9
18 dermatophytosis 10.1 CLEC7A CARD9
19 mucormycosis 10.1 CLEC7A CARD9
20 coccidioidomycosis 10.1 CLEC7A CARD9
21 nail disease 10.0 CLEC7A CARD9
22 autoimmune polyendocrine syndrome type 1 10.0 CLEC7A CARD9
23 oral candidiasis 10.0 CLEC7A CARD9
24 amyotrophic lateral sclerosis 3 9.9 TRIM21 CLEC7A
25 fungal keratitis 9.8 TLR2 CLEC7A
26 mycobacterium abscessus 9.8 TLR2 CLEC7A
27 endophthalmitis 9.7 TLR2 CARD9
28 primary systemic mycosis 9.6 TLR2 CLEC7A CARD9
29 vulvovaginal candidiasis 9.6 TLR2 CLEC7A CARD9
30 candidiasis 9.6 TLR2 CLEC7A CARD9
31 vaginal disease 9.6 TLR2 CLEC7A CARD9
32 opportunistic mycosis 9.6 TLR2 CLEC7A CARD9
33 chronic mucocutaneous candidiasis 9.6 TLR2 CLEC7A CARD9
34 invasive aspergillosis 9.6 TLR2 CLEC7A
35 inflammatory bowel disease 1 9.5 TLR2 CARD9
36 interstitial lung disease 9.5 VTN TRIM21 CD44
37 haemophilus influenzae 9.4 VTN TLR2 CLEC7A
38 lymph node disease 9.2 TRIM21 TLR2
39 amyotrophic lateral sclerosis 1 8.4 VTN TRIM21 TLR2 HSP90B1 CLEC7A CARD9

Graphical network of the top 20 diseases related to Neuroaspergillosis:



Diseases related to Neuroaspergillosis

Symptoms & Phenotypes for Neuroaspergillosis

MGI Mouse Phenotypes related to Neuroaspergillosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 CARD9 CD44 CLEC7A DYRK3 HSP90B1 TLR2

Drugs & Therapeutics for Neuroaspergillosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized Trial Comparing The Safety, Tolerability, And Efficacy Of Voriconazole And Anidulafungin In Combination To That Of Voriconazole Alone When Used For Primary Therapy Of Invasive Aspergillosis in Pediatric Subjects Aged 2 to 17 Years Withdrawn NCT01188759 Phase 3 Voriconazole;Anidulafungin;Voriconazole

Search NIH Clinical Center for Neuroaspergillosis

Cochrane evidence based reviews: neuroaspergillosis

Genetic Tests for Neuroaspergillosis

Anatomical Context for Neuroaspergillosis

MalaCards organs/tissues related to Neuroaspergillosis:

40
Brain, Liver, Lymph Node, Lung

Publications for Neuroaspergillosis

Articles related to Neuroaspergillosis:

# Title Authors PMID Year
1
Neuroaspergillosis as the Presenting Sign of a Chronic Granulomatous Disease. 61
31570298 2020
2
Aspergillosis after liver transplantation in the context of common variable immunodeficiency: case report. 61
23676145 2013
3
Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis. 61
23448824 2013
4
Neuroaspergillosis leading to blindness in a patient with multiple myeloma. 61
19884809 2010
5
[Successful treatment of neuroaspergillosis in a patient with acute lymphoblastic leukemia: role of surgery, systemic antifungal therapy and intracavitary therapy]. 61
19795628 2009
6
Cerebral aspergillosis: tissue penetration is the key. 61
19255905 2009
7
Neuroaspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid. 61
19602790 2009
8
Neuroaspergillosis in an immunocompetent patient. 61
17377359 2007
9
Neuroaspergillosis and brain tuberculosis in an immunocompetent patient with good outcome. 61
9527169 1998

Variations for Neuroaspergillosis

Expression for Neuroaspergillosis

Search GEO for disease gene expression data for Neuroaspergillosis.

Pathways for Neuroaspergillosis

Pathways related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 VTN TRIM21 TLR2 PRKCA HSP90B1 CLEC7A
2
Show member pathways
12.54 VTN TLR2 PRKCA HSP90B1
3
Show member pathways
11.93 PRKCA HSP90B1 CD44
4 11.75 TLR2 CLEC7A CARD9
5 11.57 VTN TLR2 PRKCA CD44
6
Show member pathways
11.43 TLR2 PRKCA HSP90B1
7 10.85 VTN TLR2 PRKCA CLEC7A

GO Terms for Neuroaspergillosis

Biological processes related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.46 TRIM21 TLR2 CLEC7A CARD9
2 T cell activation GO:0042110 9.32 CLEC7A CD44
3 toll-like receptor signaling pathway GO:0002224 9.26 TLR2 HSP90B1
4 positive regulation of wound healing GO:0090303 8.96 VTN CLEC7A
5 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 8.62 DYRK3 CD44

Molecular functions related to Neuroaspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling pattern recognition receptor activity GO:0008329 8.62 TLR2 CLEC7A

Sources for Neuroaspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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