MCID: NRD001
MIFTS: 35

Neurodermatitis

Categories: Neuronal diseases, Skin diseases

Aliases & Classifications for Neurodermatitis

MalaCards integrated aliases for Neurodermatitis:

Name: Neurodermatitis 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3309
MeSH 43 D009450
NCIt 49 C111963
SNOMED-CT 67 267854005
UMLS 71 C0027822

Summaries for Neurodermatitis

MalaCards based summary : Neurodermatitis is related to dermatitis, atopic and rhinitis. An important gene associated with Neurodermatitis is HR (HR Lysine Demethylase And Nuclear Receptor Corepressor). The drugs Lidocaine and Olive have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and cortex, and related phenotype is integument.

Wikipedia : 74 Lichen simplex chronicus (LSC) (also known as neurodermatitis) is a skin disorder characterized by... more...

Related Diseases for Neurodermatitis

Diseases related to Neurodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 32.0 TAC1 NPS IL4 FLG
2 rhinitis 30.1 POMC IL4 FLG
3 migraine with or without aura 1 29.5 TAC1 POMC NPS
4 prurigo nodularis 11.6
5 dermatitis 11.0
6 pustulosis of palm and sole 10.7
7 psoriasis 10.7
8 skin disease 10.5
9 cataract 10.4
10 telogen effluvium 10.4 TAC1 HR
11 carbamazepine allergy 10.4 TAC1 NPS
12 perianal hematoma 10.4 TAC1 NPS
13 causalgia 10.3 TAC1 NPS
14 aids phobia 10.3 TAC1 NPS
15 arachnoiditis 10.3 TAC1 POMC
16 epicondylitis 10.3 TAC1 NPS
17 algoneurodystrophy 10.3 TAC1 NPS
18 reflex sympathetic dystrophy 10.3 TAC1 NPS
19 vasomotor rhinitis 10.3 TAC1 NPS
20 dental pulp disease 10.3 TAC1 NPS
21 abducens nerve disease 10.3 POMC KANTR
22 urticaria 10.3
23 alopecia 10.3
24 polyradiculopathy 10.3 TAC1 NPS
25 cough variant asthma 10.3 TAC1 IL4
26 motion sickness 10.2 TAC1 POMC
27 trichinosis 10.2 POMC IL4
28 allergic rhinitis 10.2
29 parasitic ectoparasitic infectious disease 10.2 TAC1 NPS
30 autonomic nervous system disease 10.2 TAC1 NPS
31 chronic rhinitis 10.2 TAC1 IL4
32 paine syndrome 10.2 TAC1 NPS
33 infancy electroclinical syndrome 10.2 POMC KANTR
34 ige responsiveness, atopic 10.2
35 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
36 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
37 sexual disorder 10.2
38 pollen allergy 10.2
39 ichthyosis 10.2
40 lupus erythematosus 10.2
41 dermatophytosis 10.2
42 alopecia areata 10.2
43 myofascial pain syndrome 10.1 TAC1 POMC NPS
44 pain agnosia 10.1 TAC1 POMC NPS
45 agnosia 10.1 TAC1 POMC NPS
46 hyperhidrosis, gustatory 10.1 TPRA1 TAC1
47 trigeminal nerve disease 10.1 TAC1 NPS KANTR
48 trigeminal neuralgia 10.1 TAC1 NPS KANTR
49 glossopharyngeal neuralgia 10.1 TAC1 POMC KANTR
50 specific developmental disorder 10.1 TAC1 POMC NPS

Graphical network of the top 20 diseases related to Neurodermatitis:



Diseases related to Neurodermatitis

Symptoms & Phenotypes for Neurodermatitis

MGI Mouse Phenotypes related to Neurodermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 HR IL4 MRGPRD MRGPRX1 OSMR POMC

Drugs & Therapeutics for Neurodermatitis

Drugs for Neurodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Olive Phase 4
3 Evening Primrose Phase 4
4 Linoleate Phase 4
5 Lipid Regulating Agents Phase 4
6 Dermatologic Agents Phase 4
7 Hypolipidemic Agents Phase 4
8 Antimetabolites Phase 4
9 Sodium Channel Blockers Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Anesthetics Phase 4
12 Anesthetics, Local Phase 4
13 Diuretics, Potassium Sparing Phase 4
14
Evening primrose oil Investigational, Nutraceutical Phase 4 308064-97-3
15
Nalbuphine Approved Phase 2, Phase 3 20594-83-6 5311304 5360630
16
Selegiline Approved, Investigational, Vet_approved Phase 3 14611-51-9 5195 26757
17 Serlopitant Investigational Phase 3 860642-69-9
18 neurokinin A Phase 3
19
Substance P Phase 3 33507-63-0 44359816
20 Neurotransmitter Agents Phase 3
21 Narcotics Phase 2, Phase 3
22 Analgesics, Opioid Phase 2, Phase 3
23 Antidepressive Agents Phase 3
24 Psychotropic Drugs Phase 3
25 Antiparkinson Agents Phase 3
26 Neuroprotective Agents Phase 3
27 Monoamine Oxidase Inhibitors Phase 3
28 Protective Agents Phase 3
29 Calcineurin Inhibitors Phase 3
30
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
31 Immunoglobulins Phase 2
32 Antibodies Phase 2
33 Antibodies, Monoclonal Phase 2
34 Immunologic Factors Phase 2
35 Analgesics, Non-Narcotic Phase 1, Phase 2
36 Analgesics Phase 1, Phase 2
37 Anti-Inflammatory Agents Phase 1, Phase 2
38 Antirheumatic Agents Phase 1, Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
40 Pharmaceutical Solutions Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Prospective Clinical Trial to Assess the Efficacy and Safety of EPOGAM 1000 in Patients With Atopic Dermatitis (Explorative Pilot Study) Completed NCT00878670 Phase 4 EPOGAM 1000
2 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
3 Prospective, Controlled Three-Armed Study About Effectiveness and Compatibility of Silver-Containing Textiles for Treatment of Acute Neurodermatitis Completed NCT00196430 Phase 3 corticosteroid
4 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Pruritus in Adults With Prurigo Nodularis Completed NCT03546816 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
5 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Pruritus in Adults With Prurigo Nodularis Completed NCT03677401 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
6 An Open Label Extension Study of the Safety and Anti-Pruritic Efficacy of Nalbuphine HCl ER Tablets in Prurigo Nodularis Patients Completed NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
7 A Randomized, Double-Blind, Placebo-Controlled, Parallel, 3-Arm Study of the Safety and Anti-Pruritic Efficacy of Nalbuphine HCl ER Tablets in Prurigo Nodularis Patients Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
8 A Phase III Randomized Double-blind, 12 Week, Placebo Controlled Trial of Transdermal Selegiline in Borderline Personality Disorder (BPD) to Evaluate Efficacy and Safety Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
9 A Randomized, Double Blind, Placebo-controlled, Multi-center, Parallel Group Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Prurigo Nodularis Who Are Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable Recruiting NCT04202679 Phase 3 Dupilumab SAR231893;Placebo;Moisturizers;Low to medium potent topical corticosteroids;Topical calcineurin inhibitors
10 A Randomized, Double Blind, Placebo-controlled, Multi-center, Parallel Group Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Prurigo Nodularis Who Are Inadequately Controlled on Topical Prescription Therapies or When Those Therapies Are Not Advisable Recruiting NCT04183335 Phase 3 Dupilumab SAR231893;Placebo;Moisturizers;Low to medium potent topical corticosteroids;Topical calcineurin inhibitors
11 A Prospective, Multicenter, Long-Term Study to Assess the Safety and Efficacy of Nemolizumab (CD14152) in Subjects With Prurigo Nodularis Not yet recruiting NCT04204616 Phase 3 Nemolizumab
12 A Randomized, Placebo-controlled, Double-blind Study to Scrutinize the Efficacy of Secukinumab in Patients With Moderate to Severe Atopic Dermatitis Completed NCT03568136 Phase 2 Secukinumab 300 mg;Placebo
13 A Randomized, Double-Blind, Placebo-Controlled, Study of Neurokinin-1 Receptor Antagonist Serlopitant in Subjects With Prurigo Nodularis Completed NCT02196324 Phase 2 serlopitant;Placebo
14 Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis Recruiting NCT03576287 Phase 1, Phase 2 Apremilast Oral Product
15 KPL-716-C202: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Pilot Study to Investigate the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Diseases Characterized by Chronic Pruritus Active, not recruiting NCT03858634 Phase 2 KPL-716;Placebo
16 A Phase 2a/b, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of KPL-716 in Reducing Pruritus in Subjects With Prurigo Nodularis Active, not recruiting NCT03816891 Phase 2 KPL-716;Placebo
17 Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Completed NCT02732145

Search NIH Clinical Center for Neurodermatitis

Cochrane evidence based reviews: neurodermatitis

Genetic Tests for Neurodermatitis

Anatomical Context for Neurodermatitis

MalaCards organs/tissues related to Neurodermatitis:

40
Skin, Testes, Cortex, Adrenal Cortex, Eye, Neutrophil, Thymus

Publications for Neurodermatitis

Articles related to Neurodermatitis:

(show top 50) (show all 806)
# Title Authors PMID Year
1
[The health status of children and adolescents with migration background in Germany : Results from KiGGS Wave 2]. 61
31529190 2019
2
Derailed Ceramide Metabolism in Atopic Dermatitis (AD): A Causal Starting Point for a Personalized (Basic) Therapy. 61
31443157 2019
3
Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders. 61
29771216 2018
4
Perianal Dermatitis. 61
28338543 2017
5
[Neurodermatitis : Atopy of the skin]. 61
28447153 2017
6
Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta-analysis, and recommendation for uniform use of 'atopic dermatitis'. 61
27392131 2016
7
[Risk hidden in the small print? : Some food additives may trigger pseudoallergic reactions]. 61
27173908 2016
8
Hypertrophic lichen planus versus prurigo nodularis: a dermoscopic perspective. 61
27222766 2016
9
[Definition and clinic of the allergic rhinitis]. 61
27120868 2016
10
["Neurodermatitis is often considered a childhood illness"]. 61
27084140 2016
11
Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients. 61
26841932 2016
12
Inhibition of IKK-β by epidioxysterols from the flowers of Calotropis gigantea (Niu jiao gua). 61
26937251 2016
13
Recent Advances in Pharmacotherapeutic Paradigm of Mild to Recalcitrant Atopic Dermatitis. 61
27910751 2016
14
Leprosy in the Bible. 61
26773616 2016
15
[Multiple dredging method combined with regulating internal organs and spinal cord for 18 cases of neurodermatitis]. 61
26964167 2015
16
Acupuncture as a Treatment Modality in Dermatology: A Systematic Review. 61
26115180 2015
17
PSYCHOSOMATIC ASPECTS IN PATIENTS WITH DERMATOLOGIC DISEASES. 61
26087735 2015
18
[No scratching, please: 6 strategies to control neurodermatitis itch]. 61
26314172 2015
19
Dermatological Complaints of the Elderly Attending a Dermatology Outpatient Clinic in Turkey: A Prospective Study over a One-year Period. 61
26724880 2015
20
Dermatologic manifestations of fibromyalgia. 61
24420725 2014
21
[Bibliometrics analysis on researches of illness spectrum for acu-moxibustion therapy and prospect]. 61
25069204 2014
22
[Pseudo-condylomatous neurodermatitis of the anal margin]. 61
25317228 2014
23
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis. 61
23956968 2013
24
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia. 61
24403775 2013
25
Use of lenalidomide in treating refractory prurigo nodularis. 61
23545923 2013
26
Propolis: a wonder bees product and its pharmacological potentials. 61
24382957 2013
27
Quality of life of patients with neurodermatitis. 61
23533146 2013
28
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis: factitious purpura or psychophysiological entity? 61
23205328 2012
29
Real-life effect of classical homeopathy in the treatment of allergies: A multicenter prospective observational study. 61
22138796 2012
30
Sexual dysfunction in female patients with neurodermatitis. 61
20864649 2011
31
[Thirty-eight cases of neurodermatitis treated by cutting at auricular point combined with cotton-pave moxibustion]. 61
21442806 2011
32
[Evidence-based acute and long-lasting effects of climatotherapy in moderate altitudes and on the seaside]. 61
21246469 2011
33
Cancer protection of soy resembles cancer protection during pregnancy. 61
25961211 2010
34
Childhood psoriasis: a study of 137 cases from central China. 61
20549408 2010
35
Tinea incognito. 61
20347654 2010
36
[Turmoil about a substance for psoriasis and neurodermatitis. Wonder salve based on thin data (interview by Petra Eiden)]. 61
19960712 2009
37
Approach to suspected food allergy in atopic dermatitis. Guideline of the Task Force on Food Allergy of the German Society of Allergology and Clinical Immunology (DGAKI) and the Medical Association of German Allergologists (ADA) and the German Society of Pediatric Allergology (GPA). 61
19371249 2009
38
[Bilateral ocular surface squamous neoplasia and neurodermatitis. Two cases with different courses]. 61
18438629 2008
39
Prurigo nodularis: a benign dermatosis derived from a persistent pruritus. 61
18358109 2008
40
Sexual dysfunctions in patients with neurodermatitis and psoriasis. 61
18224550 2008
41
[Pulmonology of the individuals of call-up age]. 61
18154065 2007
42
Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus. 61
17567313 2007
43
Factors contributing to conductance and outcome of specific immunotherapy: data from the German National Health Interview and Examination Survey 1998. 61
17060335 2007
44
[Prevalence of somatic diseases in German children and adolescents. Results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS)]. 61
17514453 2007
45
[Observation on the therapeutic effect of a red-hot needle therapy combined with blood-letting puncture and cupping for treatment of neurodermatitis]. 61
17585666 2007
46
[Observation on clinical therapeutic effect of Yang's cotton moxibustion on neurodermatitis]. 61
17432641 2007
47
[From research to practice: skin care--merely empiric?]. 61
17619402 2007
48
[A case of concomitant hepatic lesion in a child with cystic hydatid disease and Arthropoda larva (nymph)]. 61
17436735 2007
49
Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang--a clinical observation of 47 cases. 61
17078443 2006
50
[Neurodermatitis]. 61
16807734 2006

Variations for Neurodermatitis

Expression for Neurodermatitis

Search GEO for disease gene expression data for Neurodermatitis.

Pathways for Neurodermatitis

GO Terms for Neurodermatitis

Biological processes related to Neurodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.43 TPRA1 TAC1 POMC NPS MRGPRX1 MRGPRD
2 neuropeptide signaling pathway GO:0007218 9.33 TAC1 POMC NPS
3 positive regulation of acute inflammatory response GO:0002675 9.32 TAC1 OSMR
4 positive regulation of synaptic transmission, GABAergic GO:0032230 9.26 TAC1 NPS
5 positive regulation of action potential GO:0045760 8.62 TAC1 NPS

Sources for Neurodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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