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MCID: NRD001
MIFTS: 37

Neurodermatitis

Categories: Skin diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neurodermatitis

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MalaCards integrated aliases for Neurodermatitis:

Name: Neurodermatitis 12 44 15 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3309
MeSH 44 D009450
NCIt 50 C111963
SNOMED-CT 68 156383005 267854005
UMLS 73 C0027822
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Summaries for Neurodermatitis

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MalaCards based summary : Neurodermatitis is related to prurigo nodularis and dermatitis, atopic. An important gene associated with Neurodermatitis is MS4A2 (Membrane Spanning 4-Domains A2), and among its related pathways/superpathways are NF-kappaB Signaling and Osteoclast differentiation. The drugs Peripheral Nervous System Agents and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Neurodermatitis

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Diseases related to Neurodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 prurigo nodularis 11.3
2 dermatitis, atopic 11.3
3 breast metaplastic carcinoma 10.7 FEZF1 FEZF2
4 tibial neuropathy 10.7 POMC TCOF1
5 phaeohyphomycosis 10.7 FEZF1 FEZF2
6 eyelid neoplasm 10.6 FEZF1 FEZF2
7 tarsal tunnel syndrome 10.6 POMC TCOF1
8 lymph node tuberculosis 10.6 FEZF1 FEZF2
9 myofascial pain syndrome 10.6 POMC TAC1
10 uterine inversion 10.6 FEZF1 FEZF2
11 retinitis pigmentosa 68 10.4 NPS TAC1
12 dissociative amnesia 10.4 NPS TNFSF11
13 epicondylitis 10.4 NPS TAC1
14 allergic urticaria 10.3 EHF KNG1
15 pericardial tuberculosis 10.3 CABIN1 POMC
16 thyroid crisis 10.3 KANTR POMC
17 nasal cavity disease 10.3 MS4A2 NPS TAC1
18 glomangiosarcoma 10.2 KANTR TAC1
19 psoriasis 10.1
20 cataract 10.1
21 dermatitis 10.1
22 sphenoid sinusitis 10.1 KANTR TCOF1
23 auditory agnosia 10.1 KANTR TNFSF11
24 laryngeal tuberculosis 10.1 KANTR POMC
25 glossopharyngeal neuralgia 10.0 KANTR POMC
26 anismus 10.0 KANTR TAC1
27 asthma 9.9
28 alopecia 9.9
29 dental pulp disease 9.7 NPS TAC1
30 ichthyosis vulgaris 9.7
31 retinal detachment 9.7
32 mycosis fungoides 9.7
33 reticulum cell sarcoma 9.7
34 arthritis 9.7
35 skin conditions 9.7
36 erythema multiforme 9.7
37 sarcoma 9.7
38 urticaria 9.7
39 lymphadenitis 9.7
40 ichthyosis 9.7
41 keratoacanthoma 9.7
42 purpura 9.7
43 retinitis 9.7
44 occupational dermatitis 9.7
45 peptic ulcer disease 9.7
46 lupus erythematosus 9.7
47 alopecia areata 9.7
48 bowen's disease 9.7
49 headache 9.7
50 migraine with or without aura 1 9.2 KANTR NPS TAC1

Graphical network of the top 20 diseases related to Neurodermatitis:



Diseases related to Neurodermatitis
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Symptoms & Phenotypes for Neurodermatitis

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GenomeRNAi Phenotypes related to Neurodermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 POMC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.23 IKBKB
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.23 IKBKB
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.23 IKBKB
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.23 IKBKB POMC BTK
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.23 BTK
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Drugs & Therapeutics for Neurodermatitis

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Drugs for Neurodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
2 Analgesics Phase 4,Phase 2,Phase 3
3 Analgesics, Non-Narcotic Phase 4,Phase 2
4 Anti-Inflammatory Agents Phase 4,Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
6 Antimetabolites Phase 4
7 Antirheumatic Agents Phase 4,Phase 2
8 Dermatologic Agents Phase 4,Phase 2
9 Efamol Phase 4
10 Hypolipidemic Agents Phase 4
11 Lipid Regulating Agents Phase 4
12 Evening Primrose Nutraceutical Phase 4
13 Linoleate Nutraceutical Phase 4
14 Olive Nutraceutical Phase 4
15
Nalbuphine Approved Phase 2, Phase 3,Phase 3 20594-83-6 5360630 5311304
16
Selegiline Approved, Investigational, Vet_approved Phase 3 14611-51-9 26757 5195
17 Analgesics, Opioid Phase 2, Phase 3,Phase 3
18 Antipruritics Phase 2, Phase 3,Phase 3
19 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
20 Narcotic Antagonists Phase 2, Phase 3,Phase 3
21 Narcotics Phase 2, Phase 3,Phase 3
22
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
23
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
24
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
25
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
26 Serlopitant Investigational Phase 2 860642-69-9
27
Substance P Investigational Phase 2 33507-63-0 44359816
28
Butyric Acid Experimental, Investigational Phase 2 107-92-6 264
29 Neurotransmitter Agents Phase 2,Not Applicable
30 neurokinin A Phase 2
31 Neurokinin-1 Receptor Antagonists Phase 2
32 Angiogenesis Inhibitors Phase 2
33 Angiogenesis Modulating Agents Phase 2
34 Anti-Bacterial Agents Phase 2,Not Applicable
35 Anti-Infective Agents Phase 2,Not Applicable
36 Immunosuppressive Agents Phase 2
37 Calcineurin Inhibitors Phase 2
38 Cortisol succinate Phase 2
39 Hydrocortisone 17-butyrate 21-propionate Phase 2
40 Hydrocortisone acetate Phase 2
41 Hydrocortisone-17-butyrate Phase 2
42
Citalopram Approved Not Applicable 59729-33-8 2771
43
Doxorubicin Approved, Investigational 23214-92-8 31703
44
Dapsone Approved, Investigational Not Applicable 80-08-0 2955
45
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
46
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
47
Doxil Approved June 1999 31703
48 Antidepressive Agents Not Applicable
49 Antidepressive Agents, Second-Generation Not Applicable
50 Antiparkinson Agents Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Investigation of Efficacy and Safety of EPOGAM Completed NCT00878670 Phase 4 EPOGAM 1000
2 Study About Effectiveness of Silver-Containing Textiles for Treatment of Acute Neurodermatitis Completed NCT00196430 Phase 3 corticosteroid
3 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
4 Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
5 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03546816 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
6 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Active, not recruiting NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
7 PRISM Study-Pruritus Relief Through Itch Scratch Modulation Not yet recruiting NCT03497975 Phase 2, Phase 3 Nalbuphine ER Tablets
8 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
9 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
10 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
11 Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis Recruiting NCT03576287 Phase 1, Phase 2 Apremilast Oral Product
12 Investigation of Efficacy of Secukinumab in Patients With Moderate to Serve Atopic Dermatitis Not yet recruiting NCT03568136 Phase 2 Secukinumab 300 mg;Placebo
13 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 Not Applicable citalopram (cipralex)
14 Prevalence of Food Allergies to Proteins From Different Legumes Completed NCT01728168
15 A Study to Evaluate Safety and Tolerability in Patients With Metastatic Breast Cancer Receiving Treatment With Caelyx (Study P04878)(COMPLETED) Completed NCT00736333 Pegylated Liposomal Doxorubicin
16 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
17 Dapsone Prurigo Study Not yet recruiting NCT01870050 Not Applicable Dapsone gel - verum

Search NIH Clinical Center for Neurodermatitis

Cochrane evidence based reviews: neurodermatitis

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Genetic Tests for Neurodermatitis

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Anatomical Context for Neurodermatitis

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MalaCards organs/tissues related to Neurodermatitis:

41
Skin, Testes, Eye
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Publications for Neurodermatitis

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Articles related to Neurodermatitis:

(show top 50) (show all 132)
# Title Authors Year
1
Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients. ( 26841932 )
2016
2
Quality of life of patients with neurodermatitis. ( 23533146 )
2013
3
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis. ( 23956968 )
2013
4
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia. ( 24403775 )
2013
5
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis: factitious purpura or psychophysiological entity? ( 23205328 )
2012
6
Sexual dysfunction in female patients with neurodermatitis. ( 20864649 )
2011
7
Sexual dysfunctions in patients with neurodermatitis and psoriasis. ( 18224550 )
2008
8
Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus. ( 17567313 )
2007
9
Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang--a clinical observation of 47 cases. ( 17078443 )
2006
10
Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. ( 14756886 )
2004
11
Professor Ouyang Heng's experience in treating neurodermatitis. ( 14535180 )
2003
12
The effect of topically applied aspirin on localized circumscribed neurodermatitis. ( 11712038 )
2001
13
Effects of Medical Resonance Therapy Music on patients with psoriasis and neurodermatitis--a pilot study. ( 11286371 )
2000
14
Acupuncture treatment of 139 cases of neurodermatitis. ( 10437249 )
1997
15
Psychiatric profile of patients with neurodermatitis. ( 9141851 )
1996
16
Acupuncture treatment of 139 cases of neurodermatitis. ( 8501956 )
1993
17
Treatment of prurigo nodularis, chronic prurigo and neurodermatitis circumscripta with topical capsaicin. ( 1362846 )
1992
18
Effectiveness of ketotifen in the treatment of neurodermatitis in childhood. ( 2128829 )
1990
19
[Clinical forms of atopic neurodermatitis]. ( 2202168 )
1990
20
Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. ( 2474315 )
1989
21
Cryosurgical treatment of nodular neurodermatitis with Refrigerant 12. ( 2619792 )
1989
22
Podiatric implications of neurodermatitis. ( 3385615 )
1988
23
Association of affective disorder with migraine headaches and neurodermatitis. ( 3360315 )
1988
24
Treatment of 86 cases of local neurodermatitis by electro-acupuncture (with needles inserted around diseased areas). ( 3497316 )
1987
25
Outgrowing a neurodermatitis. ( 3466887 )
1986
26
A controlled study of psychosocial factors in neurodermatitis. ( 21927162 )
1986
27
Vitiligo and neurodermatitis circumscripta. ( 3843332 )
1985
28
Neurodermatitis treated by plum-blossom needle. ( 6570497 )
1984
29
Psychological evaluation of patients with neurodermatitis circumscripta (lichen simplex chronicus). ( 6642567 )
1983
30
[Atopic neurodermatitis. Clinical course--pathophysiology--therapy]. ( 6873844 )
1983
31
The behavioral treatment of neurodermatitis through habit-reversal. ( 7271697 )
1981
32
Brief hypnotherapy of neurodermatitis: a case with four-year followup. ( 696664 )
1978
33
A follow-up study on the chemotherapy of neurodermatitis with a monoamine oxidase inhibitor. ( 650199 )
1978
34
Neurodermatitis and intralesional steroids. ( 668973 )
1978
35
Neurodermatitis--a concept. ( 648168 )
1978
36
On the treatment of neurodermatitis with a monoamine oxidase inhibitor. The chemotherapy of psychosomatic illness through A-REM suppression. ( 203659 )
1978
37
Neurodermatitis: a skin condition that affects surgical wound healing. ( 893969 )
1977
38
[Socio-medical significance of alkalie resistance, alkalie neutralization and skin-surface lipid content in atopic neurodermatitis and ichthyosis vulgaris (author's transl)]. ( 907654 )
1977
39
Atopic neurodermatitis. Clinical aspects. ( 1186669 )
1975
40
Epidermal nicotinamide adenine dinucleotides in psoriasis and neurodermatitis (lichen simplex hypertrophicus). ( 239643 )
1975
41
Atopy in lichen simplex (neurodermatitis circumscripta). ( 4802403 )
1973
42
Neurodermatitis: what is it? ( 20468757 )
1972
43
Peptic ulcer alternating with neurodermatitis circumscripta. ( 5018267 )
1972
44
Multiple keratoacanthoma-like neurodermatitis nodularis. ( 4664554 )
1972
45
Glyceraldehydephosphate dehydrogenase and glucose-6-phosphate dehydrogenase activities in psoriasis and neurodermatitis and the effect of dithranol. ( 5412727 )
1970
46
Neurodermatitis. A case report. ( 5495837 )
1970
47
Therapy in a case of neurodermatitis. ( 5293522 )
1970
48
Treatment of neurodermatitis by behavior therapy: a case study. ( 5734560 )
1968
49
Studies in the transaminase, cholinesterase, and alkaline phosphatase activity in the serum of patients with disseminated neurodermatitis. ( 4229781 )
1967
50
Aetiology of neurodermatitis. ( 5915648 )
1966
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Variations for Neurodermatitis

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Expression for Neurodermatitis

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Search GEO for disease gene expression data for Neurodermatitis.
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Pathways for Neurodermatitis

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Pathways related to Neurodermatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.77 BTK CABIN1 IKBKB TNFSF11
2
Osteoclast differentiation 37
11.44 BTK IKBKB TNFSF11
3
NF-kappa B signaling pathway 37
10.78 BTK IKBKB TNFSF11
Sources

GO Terms for Neurodermatitis

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Biological processes related to Neurodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.71 IKBKB KNG1 MS4A2 TAC1
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.54 BTK IKBKB TNFSF11
3 neuropeptide signaling pathway GO:0007218 9.5 NPS POMC TAC1
4 positive regulation of synaptic transmission, GABAergic GO:0032230 9.26 NPS TAC1
5 positive regulation of action potential GO:0045760 9.16 NPS TAC1
6 forebrain anterior/posterior pattern specification GO:0021797 8.96 FEZF1 FEZF2
7 cell dedifferentiation GO:0043697 8.62 FEZF1 FEZF2
Sources

Sources for Neurodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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