Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: NRD001
MIFTS: 37

Neurodermatitis

Categories: Neuronal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Neurodermatitis

About this section

MalaCards integrated aliases for Neurodermatitis:

Name: Neurodermatitis 12 44 15 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3309
MeSH 44 D009450
NCIt 50 C111963
UMLS 73 C0027822
Sources

Summaries for Neurodermatitis

About this section
MalaCards based summary : Neurodermatitis is related to asthma and dermatitis, atopic. An important gene associated with Neurodermatitis is MS4A2 (Membrane Spanning 4-Domains A2), and among its related pathways/superpathways are NF-kappaB Signaling and Osteoclast differentiation. The drugs Lidocaine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 76 Lichen simplex chronicus (LSC) (also known as neurodermatitis) is a skin disorder characterized by... more...

Sources

Related Diseases for Neurodermatitis

About this section

Diseases related to Neurodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 asthma 29.8 INS KNG1 MS4A2 POMC TAC1
2 dermatitis, atopic 11.5
3 prurigo nodularis 11.4
4 psoriasis 10.3
5 dermatitis 10.3
6 breast metaplastic carcinoma 10.2 FEZF1 FEZF2
7 myofascial pain syndrome 10.2 POMC TAC1
8 eyelid carcinoma 10.2 FEZF1 FEZF2
9 cataract 10.2
10 lymph node tuberculosis 10.2 FEZF1 FEZF2
11 acute laryngitis 10.2 FEZF1 FEZF2
12 scleredema adultorum 10.2 INS POMC
13 uterine inversion 10.2 FEZF1 FEZF2
14 hirata disease 10.2 INS SLC26A3
15 pituitary apoplexy 10.1 INS POMC
16 retinitis pigmentosa 68 10.1 NPS TAC1
17 pericardial tuberculosis 10.1 CABIN1 POMC
18 pancreatic endocrine carcinoma 10.1 INS POMC
19 dissociative amnesia 10.1 NPS TNFSF11
20 epicondylitis 10.1 NPS TAC1
21 mucinoses 10.1 INS POMC
22 sheehan syndrome 10.1 INS POMC
23 drug allergy 10.1 INS MS4A2
24 allergic urticaria 10.1 EHF KNG1
25 nasal cavity disease 10.1 MS4A2 NPS TAC1
26 nose disease 10.1 MS4A2 NPS TAC1
27 hyperpituitarism 10.1 INS POMC
28 urinary system disease 10.1 CABIN1 INS POMC
29 alopecia 10.0
30 autonomic nervous system disease 10.0 INS NPS TAC1
31 glomangiosarcoma 10.0 KANTR TAC1
32 sphenoid sinusitis 10.0 KANTR TCOF1
33 auditory agnosia 10.0 KANTR TNFSF11
34 anismus 9.9 KANTR TAC1
35 glossopharyngeal neuralgia 9.9 KANTR POMC
36 ichthyosis vulgaris 9.9
37 mycosis fungoides 9.9
38 reticulum cell sarcoma 9.9
39 arthritis 9.9
40 erythema multiforme 9.9
41 sarcoma 9.9
42 urticaria 9.9
43 lymphadenitis 9.9
44 ichthyosis 9.9
45 squamous cell carcinoma 9.9
46 keratoacanthoma 9.9
47 purpura 9.9
48 occupational dermatitis 9.9
49 peptic ulcer disease 9.9
50 lupus erythematosus 9.9

Graphical network of the top 20 diseases related to Neurodermatitis:



Diseases related to Neurodermatitis
Sources

Symptoms & Phenotypes for Neurodermatitis

About this section

MGI Mouse Phenotypes related to Neurodermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 BTK FEZF1 FEZF2 IKBKB INS KNG1
2 mortality/aging MP:0010768 9.36 BTK CABIN1 DDX21 FEZF1 FEZF2 IKBKB
Sources

Drugs & Therapeutics for Neurodermatitis

About this section

Drugs for Neurodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
3 Lipid Regulating Agents Phase 4
4 Efamol Phase 4
5 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
6 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
7 Olive Phase 4
8 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
9 Dermatologic Agents Phase 4,Phase 2,Phase 1
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
11 Antirheumatic Agents Phase 4,Phase 2,Phase 1
12 Antimetabolites Phase 4
13 Hypolipidemic Agents Phase 4
14 Evening Primrose Phase 4
15 Linoleate Phase 4
16 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
17 Anesthetics, Local Phase 4
18 Anesthetics Phase 4
19 Diuretics, Potassium Sparing Phase 4
20 Sodium Channel Blockers Phase 4
21 Anti-Arrhythmia Agents Phase 4
22
Nalbuphine Approved Phase 2, Phase 3,Phase 3 20594-83-6 5311304 5360630
23
Selegiline Approved, Investigational, Vet_approved Phase 3 14611-51-9 26757 5195
24 Serlopitant Investigational Phase 3,Phase 2 860642-69-9
25
Substance P Investigational Phase 3,Phase 2 33507-63-0 44359816
26 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
27 Analgesics, Opioid Phase 2, Phase 3,Phase 3
28 Antipruritics Phase 2, Phase 3,Phase 3,Phase 1
29 Narcotics Phase 2, Phase 3,Phase 3
30 Narcotic Antagonists Phase 2, Phase 3,Phase 3
31 Neurokinin-1 Receptor Antagonists Phase 3,Phase 2
32 neurokinin A Phase 3,Phase 2
33
Apremilast Approved, Investigational Phase 2,Phase 1 608141-41-9 11561674
34
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
35
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
36
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
37
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 6447131 17753757
38 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
39 Anti-Bacterial Agents Phase 2,Phase 1,Not Applicable
40 Angiogenesis Inhibitors Phase 2,Phase 1
41 Immunologic Factors Phase 2,Phase 1
42 Immunosuppressive Agents Phase 2,Phase 1
43 Angiogenesis Modulating Agents Phase 2,Phase 1
44 Hydrocortisone 17-butyrate 21-propionate Phase 2
45 Hydrocortisone-17-butyrate Phase 2
46 Calcineurin Inhibitors Phase 2
47 Cortisol succinate Phase 2
48 Antibodies, Monoclonal Phase 2
49 Immunoglobulins Phase 2
50 Pharmaceutical Solutions Phase 2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Investigation of Efficacy and Safety of EPOGAM Completed NCT00878670 Phase 4 EPOGAM 1000
2 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
3 Study About Effectiveness of Silver-Containing Textiles for Treatment of Acute Neurodermatitis Completed NCT00196430 Phase 3 corticosteroid
4 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Completed NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
5 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
6 Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
7 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03677401 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
8 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03546816 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
9 PRISM Study-Pruritus Relief Through Itch Scratch Modulation Recruiting NCT03497975 Phase 2, Phase 3 Nalbuphine ER Tablets
10 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
11 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
12 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
13 Investigation of Efficacy of Secukinumab in Patients With Moderate to Serve Atopic Dermatitis Recruiting NCT03568136 Phase 2 Secukinumab 300 mg;Placebo
14 Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis Recruiting NCT03576287 Phase 1, Phase 2 Apremilast Oral Product
15 A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Prurigo Nodularis Not yet recruiting NCT03816891 Phase 2 KPL-716;Placebo
16 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
17 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 Not Applicable citalopram (cipralex)
18 Prevalence of Food Allergies to Proteins From Different Legumes Completed NCT01728168
19 A Study to Evaluate Safety and Tolerability in Patients With Metastatic Breast Cancer Receiving Treatment With Caelyx (Study P04878)(COMPLETED) Completed NCT00736333 Pegylated Liposomal Doxorubicin
20 Dapsone Prurigo Study Not yet recruiting NCT01870050 Not Applicable Dapsone gel - verum

Search NIH Clinical Center for Neurodermatitis

Cochrane evidence based reviews: neurodermatitis

Sources

Genetic Tests for Neurodermatitis

About this section
Sources

Anatomical Context for Neurodermatitis

About this section

MalaCards organs/tissues related to Neurodermatitis:

41
Skin, Testes, Eye, Lymph Node, Pituitary, Thyroid
Sources

Publications for Neurodermatitis

About this section

Articles related to Neurodermatitis:

(show top 50) (show all 139)
# Title Authors Year
1
Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients. ( 26841932 )
2016
2
Quality of life of patients with neurodermatitis. ( 23533146 )
2013
3
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis. ( 23956968 )
2013
4
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia. ( 24403775 )
2013
5
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis: factitious purpura or psychophysiological entity? ( 23205328 )
2012
6
Sexual dysfunction in female patients with neurodermatitis. ( 20864649 )
2011
7
Sexual dysfunctions in patients with neurodermatitis and psoriasis. ( 18224550 )
2008
8
Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus. ( 17567313 )
2007
9
Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang--a clinical observation of 47 cases. ( 17078443 )
2006
10
Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. ( 14756886 )
2004
11
Professor Ouyang Heng's experience in treating neurodermatitis. ( 14535180 )
2003
12
The effect of topically applied aspirin on localized circumscribed neurodermatitis. ( 11712038 )
2001
13
Effects of Medical Resonance Therapy Music on patients with psoriasis and neurodermatitis--a pilot study. ( 11286371 )
2000
14
Acupuncture treatment of 139 cases of neurodermatitis. ( 10437249 )
1997
15
Psychiatric profile of patients with neurodermatitis. ( 9141851 )
1996
16
Acupuncture treatment of 139 cases of neurodermatitis. ( 8501956 )
1993
17
Treatment of prurigo nodularis, chronic prurigo and neurodermatitis circumscripta with topical capsaicin. ( 1362846 )
1992
18
Effectiveness of ketotifen in the treatment of neurodermatitis in childhood. ( 2128829 )
1990
19
[Clinical forms of atopic neurodermatitis]. ( 2202168 )
1990
20
Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. ( 2474315 )
1989
21
Cryosurgical treatment of nodular neurodermatitis with Refrigerant 12. ( 2619792 )
1989
22
Podiatric implications of neurodermatitis. ( 3385615 )
1988
23
Association of affective disorder with migraine headaches and neurodermatitis. ( 3360315 )
1988
24
Treatment of 86 cases of local neurodermatitis by electro-acupuncture (with needles inserted around diseased areas). ( 3497316 )
1987
25
Outgrowing a neurodermatitis. ( 3466887 )
1986
26
A controlled study of psychosocial factors in neurodermatitis. ( 21927162 )
1986
27
Quantitative and Qualitative Study of Bacterial Flora on Neurodermatitis Circumscripta. ( 28150616 )
1986
28
Squamous Cell Carcinoma on a Preexisting Plaque of Neurodermatitis. ( 28150665 )
1986
29
Vitiligo and neurodermatitis circumscripta. ( 3843332 )
1985
30
Neurodermatitis treated by plum-blossom needle. ( 6570497 )
1984
31
Psychological evaluation of patients with neurodermatitis circumscripta (lichen simplex chronicus). ( 6642567 )
1983
32
Study of Neurodermatitis Circumscripta Patients with Psychological Tests. ( 28193926 )
1982
33
The behavioral treatment of neurodermatitis through habit-reversal. ( 7271697 )
1981
34
Needs" in Patients of Neurodermatitis Circumscripta (Lichen Simplex Chronicus). ( 28218143 )
1980
35
Current dermatological therapy Neurodermatitis - the window to the soul. ( 28223604 )
1979
36
Brief hypnotherapy of neurodermatitis: a case with four-year followup. ( 696664 )
1978
37
A follow-up study on the chemotherapy of neurodermatitis with a monoamine oxidase inhibitor. ( 650199 )
1978
38
Neurodermatitis and intralesional steroids. ( 668973 )
1978
39
Neurodermatitis--a concept. ( 648168 )
1978
40
On the treatment of neurodermatitis with a monoamine oxidase inhibitor. The chemotherapy of psychosomatic illness through A-REM suppression. ( 203659 )
1978
41
Neurodermatitis: a skin condition that affects surgical wound healing. ( 893969 )
1977
42
[Socio-medical significance of alkalie resistance, alkalie neutralization and skin-surface lipid content in atopic neurodermatitis and ichthyosis vulgaris (author's transl)]. ( 907654 )
1977
43
Atopic neurodermatitis. Clinical aspects. ( 1186669 )
1975
44
Epidermal nicotinamide adenine dinucleotides in psoriasis and neurodermatitis (lichen simplex hypertrophicus). ( 239643 )
1975
45
Atopy in lichen simplex (neurodermatitis circumscripta). ( 4802403 )
1973
46
Neurodermatitis: what is it? ( 20468757 )
1972
47
Peptic ulcer alternating with neurodermatitis circumscripta. ( 5018267 )
1972
48
Multiple keratoacanthoma-like neurodermatitis nodularis. ( 4664554 )
1972
49
Glyceraldehydephosphate dehydrogenase and glucose-6-phosphate dehydrogenase activities in psoriasis and neurodermatitis and the effect of dithranol. ( 5412727 )
1970
50
Neurodermatitis. A case report. ( 5495837 )
1970
Sources

Variations for Neurodermatitis

About this section
Sources

Expression for Neurodermatitis

About this section
Search GEO for disease gene expression data for Neurodermatitis.
Sources

Pathways for Neurodermatitis

About this section

Pathways related to Neurodermatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.77 BTK CABIN1 IKBKB TNFSF11
2
Osteoclast differentiation 37
11.44 BTK IKBKB TNFSF11
3
NF-kappa B signaling pathway 37
10.78 BTK IKBKB TNFSF11
Sources

GO Terms for Neurodermatitis

About this section

Biological processes related to Neurodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 IKBKB KNG1 MS4A2 TAC1
2 Fc-epsilon receptor signaling pathway GO:0038095 9.58 BTK IKBKB MS4A2
3 neuropeptide signaling pathway GO:0007218 9.54 NPS POMC TAC1
4 negative regulation of proteolysis GO:0045861 9.46 INS KNG1
5 positive regulation of synaptic transmission, GABAergic GO:0032230 9.32 NPS TAC1
6 cell dedifferentiation GO:0043697 9.26 FEZF1 FEZF2
7 positive regulation of action potential GO:0045760 9.16 NPS TAC1
8 forebrain anterior/posterior pattern specification GO:0021797 8.96 FEZF1 FEZF2
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 BTK IKBKB INS TNFSF11
Sources

Sources for Neurodermatitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....