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MCID: NRD001
MIFTS: 39

Neurodermatitis

Categories: Neuronal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neurodermatitis

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MalaCards integrated aliases for Neurodermatitis:

Name: Neurodermatitis 12 45 15 17 74

Classifications:

MalaCards categories:
Anatomical: Skin diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3309
MeSH 45 D009450
NCIt 51 C111963
UMLS 74 C0027822
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Summaries for Neurodermatitis

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MalaCards based summary : Neurodermatitis is related to dermatitis, atopic and prurigo nodularis. An important gene associated with Neurodermatitis is MS4A2 (Membrane Spanning 4-Domains A2), and among its related pathways/superpathways are NF-kappaB Signaling and G alpha (s) signalling events. The drugs Lidocaine and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and bone.

Wikipedia : 77 Lichen simplex chronicus (LSC) (also known as neurodermatitis) is a skin disorder characterized by... more...

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Related Diseases for Neurodermatitis

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Diseases related to Neurodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 dermatitis, atopic 11.5
2 prurigo nodularis 11.5
3 breast metaplastic carcinoma 10.4 FEZF1 FEZF2
4 eyelid carcinoma 10.4 FEZF1 FEZF2
5 lymph node tuberculosis 10.4 FEZF1 FEZF2
6 acute laryngitis 10.4 FEZF1 FEZF2
7 uterine inversion 10.4 FEZF1 FEZF2
8 myofascial pain syndrome 10.4 POMC TAC1
9 psoriasis 10.3
10 scleredema adultorum 10.3 INS POMC
11 cataract 10.3
12 dermatitis 10.3
13 pituitary apoplexy 10.3 INS POMC
14 lung oat cell carcinoma 10.3 CALCA POMC
15 retinitis pigmentosa 68 10.3 NPS TAC1
16 dissociative amnesia 10.3 NPS TNFSF11
17 pancreatic endocrine carcinoma 10.3 INS POMC
18 epicondylitis 10.2 NPS TAC1
19 mucinoses 10.2 INS POMC
20 pericardial tuberculosis 10.2 CABIN1 POMC
21 acute thyroiditis 10.2 CALCA POMC
22 sheehan syndrome 10.2 INS POMC
23 burn scar 10.2 CALCA TAC1
24 drug allergy 10.2 INS MS4A2
25 paget disease of bone 5, juvenile-onset 10.2 CALCA TNFSF11
26 hypoadrenalism 10.2 CALCA POMC
27 nasal cavity disease 10.2 MS4A2 NPS TAC1
28 nose disease 10.2 MS4A2 NPS TAC1
29 reflex sympathetic dystrophy 10.2 CALCA NPS
30 hyperpituitarism 10.2 INS POMC
31 secondary hypertrophic osteoarthropathy 10.2 CALCA POMC
32 allergic urticaria 10.2 EHF KNG1
33 vasomotor rhinitis 10.2 CALCA TAC1
34 duodenal somatostatinoma 10.2 CALCA INS
35 somatostatinoma 10.2 CALCA INS
36 urinary system disease 10.2 CABIN1 INS POMC
37 cloacogenic carcinoma 10.1 CALCA NPS POMC
38 endocrine organ benign neoplasm 10.1 CALCA INS POMC
39 thyroid gland disease 10.1 CALCA INS POMC
40 asthma 10.1
41 allergic rhinitis 10.1
42 alopecia 10.1
43 pollen allergy 10.1
44 causalgia 10.1 CALCA NPS TAC1
45 glomangiosarcoma 10.0 KANTR TAC1
46 aneurysmal bone cysts 10.0 CALCA TNFSF11
47 auditory agnosia 10.0 KANTR TNFSF11
48 anismus 9.9 KANTR TAC1
49 ichthyosis vulgaris 9.9
50 ige responsiveness, atopic 9.9

Graphical network of the top 20 diseases related to Neurodermatitis:



Diseases related to Neurodermatitis
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Symptoms & Phenotypes for Neurodermatitis

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Drugs & Therapeutics for Neurodermatitis

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Drugs for Neurodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
3 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1
4 Dermatologic Agents Phase 4,Phase 2,Phase 1
5 Linoleate Phase 4
6 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1
7 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
8 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
9 Hypolipidemic Agents Phase 4
10 Lipid Regulating Agents Phase 4
11 Antimetabolites Phase 4
12 Olive Phase 4
13 Antirheumatic Agents Phase 4,Phase 2,Phase 1
14 Evening Primrose Phase 4
15 Central Nervous System Depressants Phase 4,Phase 2,Phase 3
16 Anesthetics Phase 4
17 Anti-Arrhythmia Agents Phase 4
18 Anesthetics, Local Phase 4
19 Sodium Channel Blockers Phase 4
20 Diuretics, Potassium Sparing Phase 4
21
Evening primrose oil Investigational, Nutraceutical Phase 4 308064-97-3
22
Nalbuphine Approved Phase 2, Phase 3,Phase 3 20594-83-6 5311304 5360630
23
Selegiline Approved, Investigational, Vet_approved Phase 3 14611-51-9 5195 26757
24 Serlopitant Investigational Phase 3,Phase 2 860642-69-9
25 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
26 Analgesics, Opioid Phase 2, Phase 3,Phase 3
27 Antipruritics Phase 2, Phase 3,Phase 3,Phase 1
28 Narcotics Phase 2, Phase 3,Phase 3
29 Neurokinin-1 Receptor Antagonists Phase 3,Phase 2
30
Substance P Phase 3,Phase 2 33507-63-0 44359816
31 neurokinin A Phase 3,Phase 2
32
Apremilast Approved, Investigational Phase 2,Phase 1 608141-41-9 11561674
33
Pimecrolimus Approved, Investigational Phase 2 137071-32-0 17753757 6447131
34
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
35
Tacrolimus Approved, Investigational Phase 2 104987-11-3 6473866 445643 439492
36
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
37 Immunologic Factors Phase 2,Phase 1
38 Immunosuppressive Agents Phase 2,Phase 1
39 Angiogenesis Modulating Agents Phase 2,Phase 1
40 Angiogenesis Inhibitors Phase 2,Phase 1
41 Anti-Infective Agents Phase 2,Phase 1,Not Applicable
42 Anti-Bacterial Agents Phase 2,Phase 1,Not Applicable
43 Calcineurin Inhibitors Phase 2
44 Hydrocortisone 17-butyrate 21-propionate Phase 2
45 Hydrocortisone hemisuccinate Phase 2
46 Hydrocortisone-17-butyrate Phase 2
47 Antibodies, Monoclonal Phase 2
48 Antibodies Phase 2
49 Pharmaceutical Solutions Phase 2
50 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Investigation of Efficacy and Safety of EPOGAM Completed NCT00878670 Phase 4 EPOGAM 1000
2 Pain Outcomes Following Intralesional Corticosteroid Injections Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
3 Study About Effectiveness of Silver-Containing Textiles for Treatment of Acute Neurodermatitis Completed NCT00196430 Phase 3 corticosteroid
4 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Completed NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
5 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
6 Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
7 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03677401 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
8 Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch) With Prurigo Nodularis Recruiting NCT03546816 Phase 3 5mg Serlopitant Tablets;Placebo Tablets
9 PRISM Study-Pruritus Relief Through Itch Scratch Modulation Recruiting NCT03497975 Phase 2, Phase 3 Nalbuphine ER Tablets
10 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
11 Safety and Efficacy of Nemolizumab in PN Completed NCT03181503 Phase 2 CD14152 Dose A;CD14152 placebo
12 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
13 Evaluation of the Antipruritic Effect of Elidel (Pimecrolimus) in Non-atopic Pruritic Disease Completed NCT00507832 Phase 2 Pimecrolimus;Hydrocortisone;Pimecrolimus
14 Investigation of Efficacy of Secukinumab in Patients With Moderate to Serve Atopic Dermatitis Recruiting NCT03568136 Phase 2 Secukinumab 300 mg;Placebo
15 Apremilast as Anti-pruritic Treatment in Patients With Prurigo Nodularis Recruiting NCT03576287 Phase 1, Phase 2 Apremilast Oral Product
16 A Study to Assess the Efficacy, Safety, and Tolerability of KPL-716 in Reducing Pruritus in Prurigo Nodularis Recruiting NCT03816891 Phase 2 KPL-716;Placebo
17 A Study to Assess the Efficacy, Safety and Tolerability of KPL-716 in Reducing Pruritus in Chronic Pruritic Diseases Not yet recruiting NCT03858634 Phase 2 KPL-716;Placebo
18 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
19 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 Not Applicable citalopram (cipralex)
20 Prevalence of Food Allergies to Proteins From Different Legumes Completed NCT01728168
21 A Study to Evaluate Safety and Tolerability in Patients With Metastatic Breast Cancer Receiving Treatment With Caelyx (Study P04878)(COMPLETED) Completed NCT00736333 Pegylated Liposomal Doxorubicin
22 Dapsone Prurigo Study Not yet recruiting NCT01870050 Not Applicable Dapsone gel - verum

Search NIH Clinical Center for Neurodermatitis

Cochrane evidence based reviews: neurodermatitis

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Genetic Tests for Neurodermatitis

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Anatomical Context for Neurodermatitis

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MalaCards organs/tissues related to Neurodermatitis:

42
Skin, Thyroid, Bone, Testes, Eye, Lymph Node, Pituitary
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Publications for Neurodermatitis

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Articles related to Neurodermatitis:

(show top 50) (show all 140)
# Title Authors Year
1
Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients. ( 26841932 )
2016
2
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia. ( 24403775 )
2013
3
Quality of life of patients with neurodermatitis. ( 23533146 )
2013
4
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis. ( 23956968 )
2013
5
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis: factitious purpura or psychophysiological entity? ( 23205328 )
2012
6
Sexual dysfunction in female patients with neurodermatitis. ( 20864649 )
2011
7
Sexual dysfunctions in patients with neurodermatitis and psoriasis. ( 18224550 )
2008
8
Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus. ( 17567313 )
2007
9
Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang--a clinical observation of 47 cases. ( 17078443 )
2006
10
Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. ( 14756886 )
2004
11
Professor Ouyang Heng's experience in treating neurodermatitis. ( 14535180 )
2003
12
The effect of topically applied aspirin on localized circumscribed neurodermatitis. ( 11712038 )
2001
13
Effects of Medical Resonance Therapy Music on patients with psoriasis and neurodermatitis--a pilot study. ( 11286371 )
2000
14
Acupuncture treatment of 139 cases of neurodermatitis. ( 10437249 )
1997
15
Psychiatric profile of patients with neurodermatitis. ( 9141851 )
1996
16
Acupuncture treatment of 139 cases of neurodermatitis. ( 8501956 )
1993
17
Treatment of prurigo nodularis, chronic prurigo and neurodermatitis circumscripta with topical capsaicin. ( 1362846 )
1992
18
Effectiveness of ketotifen in the treatment of neurodermatitis in childhood. ( 2128829 )
1990
19
[Clinical forms of atopic neurodermatitis]. ( 2202168 )
1990
20
Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. ( 2474315 )
1989
21
Cryosurgical treatment of nodular neurodermatitis with Refrigerant 12. ( 2619792 )
1989
22
Association of affective disorder with migraine headaches and neurodermatitis. ( 3360315 )
1988
23
Podiatric implications of neurodermatitis. ( 3385615 )
1988
24
Treatment of 86 cases of local neurodermatitis by electro-acupuncture (with needles inserted around diseased areas). ( 3497316 )
1987
25
Outgrowing a neurodermatitis. ( 3466887 )
1986
26
A controlled study of psychosocial factors in neurodermatitis. ( 21927162 )
1986
27
Quantitative and Qualitative Study of Bacterial Flora on Neurodermatitis Circumscripta. ( 28150616 )
1986
28
Squamous Cell Carcinoma on a Preexisting Plaque of Neurodermatitis. ( 28150665 )
1986
29
Vitiligo and neurodermatitis circumscripta. ( 3843332 )
1985
30
Neurodermatitis treated by plum-blossom needle. ( 6570497 )
1984
31
Psychological evaluation of patients with neurodermatitis circumscripta (lichen simplex chronicus). ( 6642567 )
1983
32
[Atopic neurodermatitis. Clinical course--pathophysiology--therapy]. ( 6873844 )
1983
33
Study of Neurodermatitis Circumscripta Patients with Psychological Tests. ( 28193926 )
1982
34
The behavioral treatment of neurodermatitis through habit-reversal. ( 7271697 )
1981
35
Needs" in Patients of Neurodermatitis Circumscripta (Lichen Simplex Chronicus). ( 28218143 )
1980
36
Current dermatological therapy Neurodermatitis - the window to the soul. ( 28223604 )
1979
37
On the treatment of neurodermatitis with a monoamine oxidase inhibitor. The chemotherapy of psychosomatic illness through A-REM suppression. ( 203659 )
1978
38
Neurodermatitis--a concept. ( 648168 )
1978
39
A follow-up study on the chemotherapy of neurodermatitis with a monoamine oxidase inhibitor. ( 650199 )
1978
40
Neurodermatitis and intralesional steroids. ( 668973 )
1978
41
Brief hypnotherapy of neurodermatitis: a case with four-year followup. ( 696664 )
1978
42
Neurodermatitis: a skin condition that affects surgical wound healing. ( 893969 )
1977
43
[Socio-medical significance of alkalie resistance, alkalie neutralization and skin-surface lipid content in atopic neurodermatitis and ichthyosis vulgaris (author's transl)]. ( 907654 )
1977
44
Epidermal nicotinamide adenine dinucleotides in psoriasis and neurodermatitis (lichen simplex hypertrophicus). ( 239643 )
1975
45
Atopic neurodermatitis. Clinical aspects. ( 1186669 )
1975
46
Atopy in lichen simplex (neurodermatitis circumscripta). ( 4802403 )
1973
47
Multiple keratoacanthoma-like neurodermatitis nodularis. ( 4664554 )
1972
48
Peptic ulcer alternating with neurodermatitis circumscripta. ( 5018267 )
1972
49
Neurodermatitis: what is it? ( 20468757 )
1972
50
Therapy in a case of neurodermatitis. ( 5293522 )
1970
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Variations for Neurodermatitis

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Expression for Neurodermatitis

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Search GEO for disease gene expression data for Neurodermatitis.
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Pathways for Neurodermatitis

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Pathways related to Neurodermatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.77 BTK CABIN1 IKBKB TNFSF11
2
G alpha (s) signalling events 67
11.6 CALCA NPS POMC
3
Osteoclast differentiation 38
11.44 BTK IKBKB TNFSF11
4
NF-kappa B signaling pathway 38
10.8 BTK IKBKB TNFSF11
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GO Terms for Neurodermatitis

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Biological processes related to Neurodermatitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.97 CALCA INS KNG1 NPS POMC TAC1
2 cell-cell signaling GO:0007267 9.73 CALCA INS POMC TAC1
3 Fc-epsilon receptor signaling pathway GO:0038095 9.65 BTK IKBKB MS4A2
4 regulation of blood pressure GO:0008217 9.58 CALCA POMC TAC1
5 inflammatory response GO:0006954 9.56 IKBKB KNG1 MS4A2 TAC1
6 negative regulation of proteolysis GO:0045861 9.55 INS KNG1
7 positive regulation of blood vessel diameter GO:0097755 9.54 CALCA INS
8 positive regulation of synaptic transmission, GABAergic GO:0032230 9.46 NPS TAC1
9 cell dedifferentiation GO:0043697 9.37 FEZF1 FEZF2
10 positive regulation of action potential GO:0045760 9.32 NPS TAC1
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.26 BTK IKBKB INS TNFSF11
12 response to pain GO:0048265 9.22 TAC1
13 vasodilation GO:0042311 9.21 KNG1
14 forebrain anterior/posterior pattern specification GO:0021797 9.16 FEZF1 FEZF2
15 neuropeptide signaling pathway GO:0007218 8.8 NPS POMC TAC1

Molecular functions related to Neurodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 CALCA KNG1 POMC
2 hormone activity GO:0005179 8.8 CALCA INS POMC
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Sources for Neurodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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