MCID: NRG003
MIFTS: 36

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 15 17 74
Arthropathy Associated with Neurological Disorder 12
Neuropathic Arthropathy 12
Arthropathy, Neurogenic 45
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD9CM 36 713.5
MeSH 45 D001177
ICD10 34 M14.6
UMLS 74 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as arthropathy associated with neurological disorder, is related to tabes dorsalis and sensory peripheral neuropathy, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is SPTLC1 (Serine Palmitoyltransferase Long Chain Base Subunit 1), and among its related pathways/superpathways are RAB GEFs exchange GTP for GDP on RABs and Salmonella infection (KEGG). The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 tabes dorsalis 29.7 NAA50 RAB7A SPTLC1
2 sensory peripheral neuropathy 29.6 NGF SPTLC1
3 neuropathy, hereditary sensory and autonomic, type v 29.3 NAA50 NGF NGFR
4 peripheral nervous system disease 29.0 MYOM2 NAA50 NGF SPTLC1
5 mitochondrial dna depletion syndrome 6 11.4
6 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.4
7 arthropathy 10.5
8 arthritis 10.3
9 charcot-marie-tooth disease, axonal, type 2b 10.2 RAB7A SPTLC1
10 osteomyelitis 10.1
11 syphilis 10.1
12 prurigo nodularis 10.1 NGF NGFR
13 diabetic foot ulcers 10.1
14 spinal cord injury 10.1
15 encephalitis 10.1
16 syphilitic myelopathy 10.1
17 rheumatoid arthritis 10.0
18 chiari malformation type ii 10.0
19 tertiary syphilis 10.0
20 chiari malformation 10.0
21 ocular dominance 10.0 NGF NGFR
22 diabetes mellitus 10.0
23 neuropathy 10.0
24 sciatic neuropathy 10.0 MYOM2 NGF
25 anhidrosis 10.0 NGF NGFR
26 hereditary sensory neuropathy 10.0 NGF SPTLC1
27 neurofibromatosis, type iv, of riccardi 10.0
28 osteoarthritis 10.0
29 autonomic neuropathy 10.0 NGF SPTLC1
30 neuropathy, hereditary sensory and autonomic, type ia 9.9 NAA50 SPTLC1
31 spondyloarthropathy 1 9.9
32 scleroderma, familial progressive 9.9
33 chondrosarcoma 9.9
34 hepatitis c virus 9.9
35 hepatitis 9.9
36 myelomeningocele 9.9
37 spinal disease 9.9
38 thrombosis 9.9
39 sarcoma 9.9
40 polyneuropathy 9.9
41 hepatitis c 9.9
42 polyradiculoneuropathy 9.9
43 ulnar neuropathy 9.9
44 pancreatitis 9.9
45 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
46 spondylitis 9.9
47 neurofibroma 9.9
48 gigantism 9.9
49 neurosyphilis 9.9
50 soft tissue sarcoma 9.9

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia, metatarsalgia

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
2
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
5
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
6
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
7 Bone Density Conservation Agents Phase 2, Phase 3
8 Hormones Phase 2, Phase 3
9 Hormone Antagonists Phase 2, Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
11 Prednisolone acetate Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3
14 Autonomic Agents Phase 2, Phase 3
15 Antineoplastic Agents, Hormonal Phase 2, Phase 3
16 Antiemetics Phase 2, Phase 3
17 Methylprednisolone Acetate Phase 2, Phase 3
18 Neuroprotective Agents Phase 2, Phase 3
19 Diphosphonates Phase 2, Phase 3
20 Gastrointestinal Agents Phase 2, Phase 3
21 glucocorticoids Phase 2, Phase 3
22 Protective Agents Phase 2, Phase 3
23
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
24
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
25
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
26 Calcium, Dietary Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Recruiting NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
2 Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot Unknown status NCT02023411 Phase 2 Teriparatide
3 Therapeutic Stockings to Prevent Foot Ulcers Unknown status NCT01221194 Not Applicable
4 Chongqing Diabetes Registry Study Recruiting NCT03692884
5 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Active, not recruiting NCT02316483
6 Offloading Interventions for Diabetic Foot Problems in Upper Egypt Not yet recruiting NCT03215953 Not Applicable

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

42
Bone

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show all 15)
# Title Authors Year
1
Knee Arthrodesis in Navajo Familial Neurogenic Arthropathy: A Case Report and Review of the Literature. ( 29252332 )
2013
2
Orthopaedic manifestations of Navajo familial neurogenic arthropathy. ( 20357597 )
2010
3
Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports. ( 15259559 )
2003
4
The management of neurogenic arthropathy: a tale of two charcots. ( 10398548 )
1999
5
Neurogenic arthropathy. Differential diagnosis. ( 1297565 )
1992
6
Radiographic and therapeutic aspects of neurogenic arthropathy. ( 1297567 )
1992
7
Pathologic features of neurogenic arthropathy. ( 1297566 )
1992
8
Neurogenic arthropathy of the hand and wrist. ( 2428861 )
1986
9
Idiopathic neurogenic arthropathy. ( 4044822 )
1985
10
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. ( 6681882 )
1983
11
Marked gallium accumulation in neurogenic arthropathy. ( 6271936 )
1981
12
Neurogenic arthropathy due to diabetes mellitus. ( 5567123 )
1971
13
Neurogenic arthropathy. A critical review. ( 14405308 )
1960
14
Neurogenic arthropathy associated with diabetes mellitus; review of the literature and report of one case in a juvenile diabetic. ( 13263342 )
1955
15
Neurogenic arthropathy (Charcot joint) associated with diabetic neuropathy; report of two cases. ( 20287629 )
1947

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

GO Terms for Neurogenic Arthropathy

Cellular components related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle membrane GO:0030670 9.26 RAB7A RAB7B
2 phagocytic vesicle GO:0045335 9.16 RAB7A RAB7B
3 vacuolar membrane GO:0005774 8.96 RAB7A RAB7B
4 endosome GO:0005768 8.8 NGFR RAB7A RAB7B

Biological processes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular protein transport GO:0006886 9.54 NGFR RAB7A RAB7B
2 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.48 NGF NGFR
3 Rho protein signal transduction GO:0007266 9.46 NGFR PECAM1
4 Rab protein signal transduction GO:0032482 9.43 RAB7A RAB7B
5 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.4 NGF NGFR
6 endosome to lysosome transport GO:0008333 9.32 RAB7A RAB7B
7 positive regulation of axonogenesis GO:0050772 9.26 NGF NGFR
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 NGF NGFR
9 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.96 NGF NGFR
10 phagosome-lysosome fusion GO:0090385 8.62 RAB7A RAB7B

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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