MCID: NRG003
MIFTS: 42

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 15 17 70
Neuropathic Arthropathy 12 32
Arthropathy Associated with Neurological Disorder 12
Arthropathy, Neurogenic 44
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD9CM 34 713.5
MeSH 44 D001177
SNOMED-CT 67 156514009
ICD10 32 M14.6
UMLS 70 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as neuropathic arthropathy, is related to polyneuropathy and osteomyelitis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is NGF (Nerve Growth Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Neuroscience. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 30.3 NGF INS CRP
2 osteomyelitis 30.1 SPTLC1 CRP CALCA
3 exostosis 29.9 COL2A1 CALCA
4 bone resorption disease 29.9 INS CRP CALCA
5 spondylolisthesis 29.8 TAC1 CRP
6 anhidrosis 29.7 NTRK1 NGF
7 neuropathy, hereditary sensory and autonomic, type iia 29.4 SPTLC1 SCN9A NTRK1 NGF
8 hereditary sensory neuropathy 29.4 SPTLC1 SCN9A NTRK1 NGF
9 sensory peripheral neuropathy 29.4 SPTLC1 SCN9A NTRK1 NGF
10 nerve compression syndrome 29.3 TAC1 NGF INS CRP
11 autonomic neuropathy 29.3 SPTLC1 SCN9A NTRK1 NGF INS
12 diabetic neuropathy 29.1 SCN9A NTRK1 NGF INS CALCA
13 neuropathy 28.9 SPTLC1 SCN9A PRDM12 NTRK1 NGF INS
14 peripheral nervous system disease 28.3 TAC1 SPTLC1 SCN9A NTRK1 NGF INS
15 mitochondrial dna depletion syndrome 6 11.4
16 arthropathy 10.6
17 syphilis 10.3
18 sepsis in premature infants 10.3 CRP CALCA
19 external ear carcinoma 10.3 CRP CALCA
20 discitis 10.2 CRP CALCA
21 malignant otitis externa 10.2 INS CRP
22 otitis externa 10.2 INS CRP
23 uvulitis 10.2 INS CRP
24 acute cholangitis 10.2 CRP CALCA
25 neurotic disorder 10.2 NGF INS
26 diabetic encephalopathy 10.2 NGF INS
27 cavernous sinus thrombosis 10.2 INS CRP
28 silent myocardial infarction 10.2 INS CRP
29 critical illness polyneuropathy 10.2 INS CRP
30 mediastinitis 10.2 INS CRP
31 inflammatory and toxic neuropathy 10.2 INS CRP
32 external ear disease 10.2 INS CRP
33 generalized atherosclerosis 10.2 INS CRP
34 balanitis 10.2 INS CRP
35 benign essential hypertension 10.2 INS CRP
36 raynaud disease 10.2 CRP CALCA
37 acute insulin response 10.2 INS CRP
38 chronic pyelonephritis 10.2 CRP CALCA
39 kwashiorkor 10.2 INS CRP
40 duodenitis 10.2 INS CRP
41 erysipelas 10.2 CRP CALCA
42 diabetic autonomic neuropathy 10.2 NGF INS
43 asphyxia neonatorum 10.2 INS CRP
44 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.2 INS CRP
45 capillary lymphangioma 10.2 NTRK1 CRP
46 background diabetic retinopathy 10.2 INS CRP
47 septic arthritis 10.2
48 chiari malformation 10.2
49 ocular cicatricial pemphigoid 10.2 NTRK1 NGF
50 mucormycosis 10.2 INS CRP

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia; metatarsalgia

GenomeRNAi Phenotypes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.58 NTRK1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-141 9.58 SPTLC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.58 NGF
4 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.58 SPTLC1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 NTRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.58 NGF
7 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.58 NTRK1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.58 SPTLC1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 NGF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 NGF
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.58 NGF NTRK1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.58 NTRK1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.58 NTRK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 NTRK1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.58 SPTLC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.58 NTRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.58 SPTLC1

MGI Mouse Phenotypes related to Neurogenic Arthropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 COL2A1 INS NGF NTRK1 PRDM12 SCN9A
2 integument MP:0010771 9.43 INS NGF NTRK1 PRDM12 SCN9A TAC1
3 normal MP:0002873 9.1 COL2A1 INS NGF NTRK1 SCN9A TAC1

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
3
Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
4
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
5
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
6
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
7
Denosumab Approved Phase 3 615258-40-7
8
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
9 Gastrointestinal Agents Phase 2, Phase 3
10 Hormones Phase 2, Phase 3
11 Antiemetics Phase 2, Phase 3
12 Methylprednisolone Acetate Phase 2, Phase 3
13 Neuroprotective Agents Phase 2, Phase 3
14 Diphosphonates Phase 2, Phase 3
15 Protective Agents Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17 glucocorticoids Phase 2, Phase 3
18 Antineoplastic Agents, Hormonal Phase 2, Phase 3
19 Anti-Inflammatory Agents Phase 2, Phase 3
20
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
21
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
22 Calcium, Dietary Phase 2
23 Antirheumatic Agents Phase 1, Phase 2
24 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
25
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
2 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Completed NCT03174366 Phase 3 Denosumab
3 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Completed NCT02023411 Phase 2 Teriparatide
4 A Long-Term Outcome Study With the IL-1 Receptor Antagonist Anakinra/Kineret in Patients With Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) A Therapeutic Approach to Study the Pathogenesis of This Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
5 Characterizing and Diagnosis's of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients Unknown status NCT00157222
6 Follow-up on Cross-sectional Study of Known Population With Charcot Osteoarthropathy - Metabolic, Physiologic and Pathologic Changes Completed NCT02335931
7 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Completed NCT02316483
8 Neurogenic Inflammation in Diabetic Polyneuropathy and Charcot Neuro-osteoarthropathy: Response to Intracutaneous Candida Albicans Completed NCT01370837
9 Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy Completed NCT02386579
10 Assessment of Surgical Correction of Deformity in Diabetic Charcot Arthropathy of the Foot and Ankle Not yet recruiting NCT04039308
11 Effect Of Charcot Restraint Orthotic Walker Three-Dimensional Printed Sole On Charcot Foot Ulcer Not yet recruiting NCT04668755

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

40
Bone, Spinal Cord, Thyroid, Pancreas, Dorsal Root Ganglion, Heart, Skin

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show top 50) (show all 270)
# Title Authors PMID Year
1
Syringomyelia presenting as neuropathic arthropathy of basal and shoulder joints. 61
33196420 2020
2
Chronic axonal idiopathic polyneuropathy: is it really benign. 61
32773448 2020
3
Neuropathic Arthropathy of a Knee Joint: A Case Report. 61
33070492 2020
4
Bone Mineral Density in Diabetes Mellitus Foot Patients for Prediction of Diabetic Neuropathic Osteoarthropathic Fracture. 61
32911585 2020
5
Novel FEMASK-score, a histopathologic assessment for destructive Charcot neuropathic arthropathy, reveals intraneural vasculopathy and correlates with progression and best treatment. 61
32619921 2020
6
Clinical insights into Charcot foot. 61
32641254 2020
7
Surgical treatment of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes: a systematic review. 61
32530758 2020
8
History of etidronate. 61
31911206 2020
9
Charcot Reconstruction: Understanding and Treating the Deformed Charcot Neuropathic Arthropathic Foot. 61
32146981 2020
10
Non-infectious thoracic discitis: A diagnostic and management dilemma. A report of two cases with review of the literature. 61
31931336 2020
11
[From cellulitis to arthrodesis]. 61
32022495 2020
12
Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics. 61
30772132 2020
13
ACR Appropriateness Criteria® Suspected Osteomyelitis of the Foot in Patients With Diabetes Mellitus. 61
31685111 2019
14
Neuropathic Arthropathy of the Shoulder: A Systematic Review of Classifications and Treatments. 61
31663919 2019
15
[Neurogenic arthropathy of the lumbosacral spine:one case report and literature review]. 61
32512970 2019
16
Brachioradialis muscle flap for posterior elbow defects: a simple and effective solution for the upper limb surgeon. 61
31227467 2019
17
Neuropathic arthropathy of the shoulder joint caused by syringomyelia: report of a rare case. 61
30850574 2019
18
Imaging of Progressive Neuropathic Arthropathy of the Shoulder. 61
29979203 2019
19
The many facets of neuropathic arthropathy. 61
33178926 2019
20
Neuropathic arthropathy of the shoulder joint secondary to a syringomyelia. 61
30567186 2018
21
The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection. 61
29684943 2018
22
Rapidly Destructive Arthrosis of Bilateral Humeral Heads Caused by Subchondral Insufficiency Fracture. 61
30369611 2018
23
Dynamic contrast-enhanced magnetic resonance imaging for differentiating osteomyelitis from acute neuropathic arthropathy in the complicated diabetic foot. 61
29654348 2018
24
Charcot arthropathy of the shoulder joint as a presenting feature of basilar impression with syringomyelia: A case report and literature review. 61
29995782 2018
25
Neuropathic Arthropathy of the Glenohumeral Joint A Review of the Literature. 61
29799367 2018
26
[Charcot foot masked by erysipelas and peripheral arterial disease]. 61
29184984 2018
27
Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. 61
29058098 2018
28
Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography. 61
29844940 2018
29
Diabetic Neuropathic Arthropathy of the Knee: Two Case Reports and a Review of the Literature. 61
29610694 2018
30
Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot. 61
28696850 2017
31
Multifocal neuropathic arthropathy in patient with undiagnosed neurosyphilis: A case report. 61
27810982 2017
32
Effectiveness of Hindfoot Arthrodesis by Stable Internal Fixation in Various Eichenholtz Stages of Neuropathic Ankle Arthropathy. 61
28110796 2017
33
Charcot arthropathy of the knee after unsuccessful spinal stenosis surgery: A case report. 61
28511074 2017
34
Outcome after protected full weightbearing treatment in an orthopedic device in diabetic neuropathic arthropathy (Charcot arthropathy): a comparison of unilaterally and bilaterally affected patients. 61
28031030 2016
35
A rare case of idiopathic thumb CMC joint neuropathic arthropathy complicated by blunt trauma. 61
28018094 2016
36
Syringomyelic Neuropathic Arthropathy of the Elbow. 61
27736857 2016
37
The Charcot foot: pathophysiology, diagnosis and classification. 61
27587513 2016
38
Rheumatoid arthritis and tabetic arthropathy: physiopathological link or simple association? 61
27708969 2016
39
Neuropathic arthropathy of the elbow treated with double-plate arthrodesis and resection site bone graft. 61
27583001 2016
40
[Charcot arthropathy and diabetic foot]. 61
27627777 2016
41
Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience. 61
27656656 2016
42
Unilateral neuropathic arthropathy of the shoulder secondary to syringomyelia: Diagnostic challenges. 61
26677453 2015
43
Factors Affecting the Outcomes of Uncomplicated Primary Open Ankle Arthrodesis. 61
25994833 2015
44
Sensory manifestations of diabetic neuropathies: anatomical and clinical correlations. 61
25614497 2015
45
Pediatric neuropathic arthropathy initially masquerading as inflammatory arthritis. 61
25275767 2014
46
A rare case of ipsilateral shoulder and thumb CMC joint neuropathic arthropathy. 61
24914106 2014
47
Neuropathic arthropathy and syringomyelia complicating a case of ankylosing spondylitis with peripheral arthritis. 61
24957593 2014
48
A case report of Charcot arthropathy caused by syringomyelia and Chiari malformation complicated with scoliosis. 61
24886292 2014
49
Charcot's Elbow Following Syringomyelia: Revisited. 61
26905711 2014
50
Outpatient assessment and management of the diabetic foot. 61
24559880 2014

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

Pathways related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 NTRK1 NGF INS COL2A1
2 11.46 SCN9A NTRK1 NGF CALCA
3
Show member pathways
10 NTRK1 NGF

GO Terms for Neurogenic Arthropathy

Cellular components related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 TAC1 NGF INS CRP COL2A1 CALCA
2 axon GO:0030424 9.02 TAC1 SCN9A NTRK1 NGF CALCA
3 endosome lumen GO:0031904 8.96 NGF INS

Biological processes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.65 TAC1 INS CALCA
2 inflammatory response GO:0006954 9.62 TAC1 SCN9A CRP CALCA
3 acute-phase response GO:0006953 9.49 INS CRP
4 positive regulation of Ras protein signal transduction GO:0046579 9.46 NTRK1 NGF
5 neurotrophin TRK receptor signaling pathway GO:0048011 9.43 NTRK1 NGF
6 positive regulation of blood vessel diameter GO:0097755 9.4 INS CALCA
7 response to pain GO:0048265 9.37 TAC1 CALCA
8 cellular response to nerve growth factor stimulus GO:1990090 9.33 TAC1 NTRK1 CALCA
9 nerve growth factor signaling pathway GO:0038180 9.26 NTRK1 NGF
10 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.13 PRDM12 NTRK1 CALCA
11 sensory perception of pain GO:0019233 8.92 TAC1 SCN9A PRDM12 NTRK1

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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