MCID: NRG003
MIFTS: 34

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 15 73
Arthropathy Associated with Neurological Disorder 12
Neuropathic Arthropathy 12
Arthropathy, Neurogenic 44
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD10 33 M14.6
ICD9CM 35 713.5
MeSH 44 D001177
UMLS 73 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as arthropathy associated with neurological disorder, is related to sensory peripheral neuropathy and neuropathy, hereditary sensory and autonomic, type v, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is SPTLC1 (Serine Palmitoyltransferase Long Chain Base Subunit 1), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and p75(NTR)-mediated signaling. The drugs Hyaluronic acid and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include bone and heart.

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 sensory peripheral neuropathy 29.7 NGF SPTLC1
2 neuropathy, hereditary sensory and autonomic, type v 29.5 NAA50 NGF NGFR
3 peripheral nervous system disease 29.3 MYOM2 NAA50 NGF SPTLC1
4 mitochondrial dna depletion syndrome 6 11.4
5 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.4
6 arthropathy 10.5
7 joint disorders 10.4
8 syringomyelia 10.4
9 charcot-marie-tooth disease, axonal, type 2b 10.1 RAB7A SPTLC1
10 arthritis 10.1
11 osteomyelitis 10.1
12 prurigo nodularis 10.1 NGF NGFR
13 syphilis 10.1
14 tertiary syphilis 10.1
15 chiari malformation 10.1
16 ocular dominance 10.0 NGF NGFR
17 hereditary sensory neuropathy 10.0 NGF SPTLC1
18 sciatic neuropathy 10.0 MYOM2 NGF
19 diabetes mellitus 10.0
20 neuropathy 10.0
21 anhidrosis 10.0 NGF NGFR
22 autonomic neuropathy 10.0 NGF SPTLC1
23 neuropathy, hereditary sensory and autonomic, type ia 10.0 NAA50 SPTLC1
24 congenital epulis 10.0 HBA1 NGFR
25 glomeruloid hemangioma 10.0 HBA1 MYOM2
26 hemangiopericytoma, malignant 10.0 HBA1 NGFR
27 sweat gland disease 9.9 NAA50 NGF
28 heart valve disease 9.9 MYOM2 PDLIM1
29 spondyloarthropathy 1 9.9
30 rheumatoid arthritis 9.9
31 chondrosarcoma 9.9
32 hepatitis c virus 9.9
33 hepatitis 9.9
34 myelomeningocele 9.9
35 spinal disease 9.9
36 thrombosis 9.9
37 hepatitis c 9.9
38 polyradiculoneuropathy 9.9
39 ulnar neuropathy 9.9
40 pancreatitis 9.9
41 chronic inflammatory demyelinating polyradiculoneuropathy 9.9
42 spondylitis 9.9
43 neurofibroma 9.9
44 gigantism 9.9
45 neurosyphilis 9.9
46 syringohydromyelia 9.9
47 charcot-marie-tooth disease, axonal, type 2k 9.9 NAA50 RAB7A
48 diabetic neuropathy 9.9
49 tabes dorsalis 9.9 NAA50 RAB7A SPTLC1
50 tertiary neurosyphilis 9.9 NAA50 RAB7A SPTLC1

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia, metatarsalgia

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2 Adjuvants, Immunologic Phase 4
3 Protective Agents Phase 4,Phase 2,Phase 3
4 Viscosupplements Phase 4
5 Immunologic Factors Phase 4
6
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
7
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
8
Zoledronic acid Approved Phase 2, Phase 3 118072-93-8 68740
9
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
11
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
12 Methylprednisolone acetate Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3
14 Antineoplastic Agents, Hormonal Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Autonomic Agents Phase 2, Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3
19 Prednisolone acetate Phase 2, Phase 3
20 Hormones Phase 2, Phase 3
21 Neuroprotective Agents Phase 2, Phase 3
22 Antiemetics Phase 2, Phase 3
23 Bone Density Conservation Agents Phase 2, Phase 3
24 Hormone Antagonists Phase 2, Phase 3
25 Diphosphonates Phase 2, Phase 3
26 Gastrointestinal Agents Phase 2, Phase 3
27
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
28 Calcium, Dietary Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis Recruiting NCT02984228 Phase 4 Hyaluronic Acid
2 Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Recruiting NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
3 Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot Active, not recruiting NCT02023411 Phase 2 Teriparatide
4 Therapeutic Stockings to Prevent Foot Ulcers Unknown status NCT01221194 Not Applicable
5 Chongqing Diabetes Registry Study Recruiting NCT03692884
6 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Active, not recruiting NCT02316483
7 Offloading Interventions for Diabetic Foot Problems in Upper Egypt Not yet recruiting NCT03215953 Not Applicable

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

41
Bone, Heart

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show all 15)
# Title Authors Year
1
Knee Arthrodesis in Navajo Familial Neurogenic Arthropathy: A Case Report and Review of the Literature. ( 29252332 )
2013
2
Orthopaedic manifestations of Navajo familial neurogenic arthropathy. ( 20357597 )
2010
3
Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports. ( 15259559 )
2003
4
The management of neurogenic arthropathy: a tale of two charcots. ( 10398548 )
1999
5
Neurogenic arthropathy. Differential diagnosis. ( 1297565 )
1992
6
Radiographic and therapeutic aspects of neurogenic arthropathy. ( 1297567 )
1992
7
Pathologic features of neurogenic arthropathy. ( 1297566 )
1992
8
Neurogenic arthropathy of the hand and wrist. ( 2428861 )
1986
9
Idiopathic neurogenic arthropathy. ( 4044822 )
1985
10
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. ( 6681882 )
1983
11
Marked gallium accumulation in neurogenic arthropathy. ( 6271936 )
1981
12
Neurogenic arthropathy due to diabetes mellitus. ( 5567123 )
1971
13
Neurogenic arthropathy. A critical review. ( 14405308 )
1960
14
Neurogenic arthropathy associated with diabetes mellitus; review of the literature and report of one case in a juvenile diabetic. ( 13263342 )
1955
15
Neurogenic arthropathy (Charcot joint) associated with diabetic neuropathy; report of two cases. ( 20287629 )
1947

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

Pathways related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 NGF NGFR
2
Show member pathways
10.98 NGF NGFR
3
Show member pathways
10.74 NGF NGFR
4 10.13 NGF NGFR

GO Terms for Neurogenic Arthropathy

Biological processes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.32 NGF NGFR
2 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.26 NGF NGFR
3 positive regulation of axonogenesis GO:0050772 9.16 NGF NGFR
4 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 NGF NGFR
5 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 8.62 NGF NGFR

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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