MCID: NRG003
MIFTS: 29

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 15 73
Arthropathy Associated with Neurological Disorder 12
Neuropathic Arthropathy 12
Arthropathy, Neurogenic 44
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD10 33 M14.6
ICD9CM 35 713.5
MeSH 44 D001177
UMLS 73 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as arthropathy associated with neurological disorder, is related to mitochondrial dna depletion syndrome 6 and mpv17-related hepatocerebral mitochondrial dna depletion syndrome, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1). The drugs Hyaluronic acid and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 mitochondrial dna depletion syndrome 6 11.2
2 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.2
3 arthropathy 10.4
4 ovary sarcoma 10.1 CD34 HBA1
5 ovarian angiosarcoma 10.1 CD34 HBA1
6 intravascular fasciitis 10.1 CD34 HBA1
7 pediatric angiosarcoma 10.1 CD34 HBA1
8 thyroid angiosarcoma 10.1 CD34 HBA1
9 spleen angiosarcoma 10.1 CD34 HBA1
10 bone epithelioid hemangioma 10.1 CD34 HBA1
11 thyroid sarcoma 10.1 CD34 HBA1
12 hobnail hemangioma 10.1 CD34 HBA1
13 hemangioma of liver 10.1 CD34 HBA1
14 extraosseous osteosarcoma 10.1 CD34 HBA1
15 spleen cancer 10.0 CD34 HBA1
16 breast angiosarcoma 10.0 CD34 HBA1
17 conventional angiosarcoma 10.0 CD34 HBA1
18 venous hemangioma 10.0 CD34 HBA1
19 mixed liposarcoma 10.0 CD34 HBA1
20 senile angioma 10.0 CD34 HBA1
21 interstitial emphysema 10.0 CD34 HBA1
22 angiomyoma 10.0 CD34 HBA1
23 chorioangioma 10.0 CD34 HBA1
24 spindle cell liposarcoma 10.0 CD34 HBA1
25 mesenchymal cell neoplasm 10.0 CD34 HBA1
26 infiltrating lipoma 10.0 CD34 HBA1
27 lymphangiosarcoma 10.0 CD34 HBA1
28 hemangioma of intra-abdominal structure 9.9 CD34 HBA1
29 congenital epulis 9.9 CD34 HBA1
30 liver angiosarcoma 9.9 CD34 HBA1
31 diabetes mellitus 9.9
32 neuropathy 9.9
33 cardiovascular organ benign neoplasm 9.9 CD34 HBA1
34 benign perivascular tumor 9.9 CD34 HBA1
35 nephrogenic adenofibroma 9.9 CD34 HBA1
36 glomangioma 9.8 CD34 HBA1
37 connective tissue cancer 9.8 CD34 HBA1
38 diabetic neuropathy 9.8
39 tethered spinal cord syndrome 9.8
40 hypoglycemic coma 9.7 HBA1 INS
41 type 1 diabetes mellitus 7 9.7 HBA1 INS
42 type 1 diabetes mellitus 11 9.7 HBA1 INS
43 cell type cancer 9.6 CD34 HBA1
44 bone marrow cancer 9.6 CD34 MYOM2
45 cell type benign neoplasm 9.5 CD34 INS
46 glomeruloid hemangioma 9.5 CD34 HBA1 MYOM2
47 peripheral nervous system disease 9.5 INS MYOM2
48 retinal vascular disease 9.4 HBA1 INS
49 myeloma, multiple 9.3 CD34 MYOM2
50 glucose metabolism disease 9.3 HBA1 INS

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia, metatarsalgia

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2 Adjuvants, Immunologic Phase 4
3 Protective Agents Phase 4,Phase 2,Phase 3
4 Viscosupplements Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
7
Zoledronic acid Approved Phase 2, Phase 3 118072-93-8 68740
8 Antiemetics Phase 2, Phase 3
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Autonomic Agents Phase 2, Phase 3
12 Bone Density Conservation Agents Phase 2, Phase 3
13 Diphosphonates Phase 2, Phase 3
14 Gastrointestinal Agents Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Methylprednisolone acetate Phase 2, Phase 3
20 Methylprednisolone Hemisuccinate Phase 2, Phase 3
21 Neuroprotective Agents Phase 2, Phase 3
22 Peripheral Nervous System Agents Phase 2, Phase 3
23 Prednisolone acetate Phase 2, Phase 3
24 Prednisolone hemisuccinate Phase 2, Phase 3
25 Prednisolone phosphate Phase 2, Phase 3
26
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
27 Calcium, Dietary Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis Recruiting NCT02984228 Phase 4 Hyaluronic Acid
2 Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Recruiting NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
3 Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot Active, not recruiting NCT02023411 Phase 2 Teriparatide
4 Therapeutic Stockings to Prevent Foot Ulcers Unknown status NCT01221194 Not Applicable
5 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Recruiting NCT02316483
6 Offloading Interventions for Diabetic Foot Problems in Upper Egypt Not yet recruiting NCT03215953 Not Applicable

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

41
Bone

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show all 16)
# Title Authors Year
1
Knee Arthrodesis in Navajo Familial Neurogenic Arthropathy: A Case Report and Review of the Literature. ( 29252332 )
2013
2
Orthopaedic manifestations of Navajo familial neurogenic arthropathy. ( 20357597 )
2010
3
Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports. ( 15259559 )
2003
4
The management of neurogenic arthropathy: a tale of two charcots. ( 10398548 )
1999
5
Neurogenic arthropathy. Differential diagnosis. ( 1297565 )
1992
6
Radiographic and therapeutic aspects of neurogenic arthropathy. ( 1297567 )
1992
7
Pathologic features of neurogenic arthropathy. ( 1297566 )
1992
8
Neurogenic arthropathy of the hand and wrist. ( 2428861 )
1986
9
Idiopathic neurogenic arthropathy. ( 4044822 )
1985
10
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. ( 6681882 )
1983
11
Marked gallium accumulation in neurogenic arthropathy. ( 6271936 )
1981
12
Neurogenic arthropathies (Charcot's joints) in children. Description of a case traced or occult spinal dysraphism. ( 1095279 )
1975
13
Neurogenic arthropathy due to diabetes mellitus. ( 5567123 )
1971
14
Neurogenic arthropathy. A critical review. ( 14405308 )
1960
15
Neurogenic arthropathy associated with diabetes mellitus; review of the literature and report of one case in a juvenile diabetic. ( 13263342 )
1955
16
Neurogenic arthropathy (Charcot joint) associated with diabetic neuropathy; report of two cases. ( 20287629 )
1947

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

GO Terms for Neurogenic Arthropathy

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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