MCID: NRG003
MIFTS: 39

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 15 17 71
Neuropathic Arthropathy 12 32
Arthropathy Associated with Neurological Disorder 12
Arthropathy, Neurogenic 43
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD9CM 34 713.5
MeSH 43 D001177
SNOMED-CT 67 67536000
ICD10 32 M14.6
UMLS 71 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as neuropathic arthropathy, is related to spondylolisthesis and exostosis, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is NAA30 (N-Alpha-Acetyltransferase 30, NatC Catalytic Subunit), and among its related pathways/superpathways is Activation of TRKA receptors. The drugs Hyaluronic acid and Viscosupplements have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and dorsal root ganglion, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 spondylolisthesis 30.2 HECTD4 CRP
2 exostosis 29.8 HECTD4 CALCA
3 neuropathy, hereditary sensory and autonomic, type iia 29.4 SPTLC1 NTRK1 NGF NAA50
4 anhidrosis 29.3 SPTLC1 NTRK1 NGF NAA50
5 hereditary sensory neuropathy 29.3 SPTLC1 NTRK1 NGF NAA50
6 polyneuropathy 29.2 NGF INS CRP CALCA
7 autonomic neuropathy 29.0 SPTLC1 NTRK1 NGF INS
8 nerve compression syndrome 28.9 NGF INS HECTD4 CRP
9 bone resorption disease 28.7 INS HECTD4 CRP CALCA
10 diabetic neuropathy 28.6 NTRK1 NGF INS CALCA
11 sensory peripheral neuropathy 28.3 SPTLC1 NTRK1 NGF NAA50 HECTD4 CALCA
12 peripheral nervous system disease 27.4 SPTLC1 NTRK1 NGF NAA50 INS HECTD4
13 mitochondrial dna depletion syndrome 6 11.7
14 arthropathy 10.7
15 ochronosis 10.4 NAA50 NAA30
16 syphilis 10.3
17 mononeuritis of lower limb 10.3 NGF HECTD4
18 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 10.3 SPTLC1 NAA50
19 neuropathy, hereditary sensory and autonomic, type ic 10.3 SPTLC1 NAA50
20 neuropathy, hereditary sensory and autonomic, type ia 10.3 SPTLC1 NAA50
21 ogden syndrome 10.3 NAA50 NAA30
22 acute dacryoadenitis 10.3 HECTD4 CRP
23 calcific tendinitis 10.2 HECTD4 CRP
24 tendinitis 10.2 HECTD4 CRP
25 spinal cord injury 10.2
26 lymphangitis 10.2 HECTD4 CRP
27 charcot-marie-tooth disease, axonal, type 2b 10.2 SPTLC1 NAA50
28 cauda equina syndrome 10.2 HECTD4 CRP
29 tenosynovitis 10.2 HECTD4 CRP
30 subungual glomus tumor 10.2 HECTD4 CRP
31 septic arthritis 10.2
32 chiari malformation 10.2
33 insensitivity to pain, congenital, with anhidrosis 10.2 NTRK1 NAA50
34 bursitis 10.2 HECTD4 CRP
35 enthesopathy 10.2 HECTD4 CRP
36 periostitis 10.2 HECTD4 CRP
37 syringomyelia, noncommunicating isolated 10.2
38 syringomyelia 10.2
39 myofascial pain syndrome 10.2 HECTD4 CALCA
40 barre-lieou syndrome 10.2 HECTD4 CALCA
41 epicondylitis 10.2 HECTD4 CALCA
42 reflex sympathetic dystrophy 10.2 HECTD4 CALCA
43 detrusor sphincter dyssynergia 10.2 NGF CALCA
44 osteonecrosis 10.2
45 chiari malformation type ii 10.2
46 asymptomatic neurosyphilis 10.2
47 neurosyphilis 10.2
48 compartment syndrome 10.2 HECTD4 CRP
49 encephalomalacia 10.2 HECTD4 CRP
50 chronic recurrent multifocal osteomyelitis 10.1 HECTD4 CRP

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia, metatarsalgia

GenomeRNAi Phenotypes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.58 NTRK1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-141 9.58 SPTLC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.58 NGF
4 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.58 SPTLC1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.58 NTRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.58 NGF
7 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.58 NTRK1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.58 SPTLC1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.58 NGF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.58 NGF
11 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.58 NGF NTRK1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.58 NTRK1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.58 NTRK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 NTRK1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.58 SPTLC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.58 NTRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.58 SPTLC1

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2 Viscosupplements Phase 4
3 Adjuvants, Immunologic Phase 4
4 Protective Agents Phase 4
5 Immunologic Factors Phase 4
6
Denosumab Approved Phase 3 615258-40-7
7
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
8
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
9
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
10
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
11
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
12 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
13
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
14 Hormones Phase 2, Phase 3
15 Antineoplastic Agents, Hormonal Phase 2, Phase 3
16 Methylprednisolone Acetate Phase 2, Phase 3
17 Hormone Antagonists Phase 2, Phase 3
18 glucocorticoids Phase 2, Phase 3
19 Antiemetics Phase 2, Phase 3
20 Neuroprotective Agents Phase 2, Phase 3
21 Gastrointestinal Agents Phase 2, Phase 3
22 Diphosphonates Phase 2, Phase 3
23 Anti-Inflammatory Agents Phase 2, Phase 3
24
Parathyroid hormone Approved, Investigational Phase 2 9002-64-6
25
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
26 Calcium, Dietary Phase 2
27 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
28 Antirheumatic Agents Phase 1, Phase 2
29
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Ultrasound Guided Glenohumeral Joint Injections of Platelet Rich Plasma (PRP) Versus Hyaluronic Acid (HA) in the Treatment of Glenohumeral Osteoarthritis: a Randomized, Double-blind Control Trial Active, not recruiting NCT02984228 Phase 4 Hyaluronic Acid
2 Investigating the Use of Prolia (Denosumab) in the Treatment of Acute Charcot Neuroarthropathy Completed NCT03174366 Phase 3 Denosumab
3 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
4 To Study the Efficacy of Teriparatide in Improving Remodeling of Foot Bones in Chronic Charcot Neuroarthropathy in Patients With Diabetes Mellitus. Unknown status NCT02023411 Phase 2 Teriparatide
5 A Long-Term Outcome Study With the IL-1 Receptor Antagonist Anakinra/Kineret in Patients With Neonatal Onset Multisystem Inflammatory Disease (NOMID/CINCA Syndrome) A Therapeutic Approach to Study the Pathogenesis of This Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
6 Characterizing and Diagnosis’s of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients Unknown status NCT00157222
7 Follow-up on Cross-sectional Study of Known Population With Charcot Osteoarthropathy - Metabolic, Physiologic and Pathologic Changes Completed NCT02335931
8 Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy Completed NCT02386579
9 Neurogenic Inflammation in Diabetic Polyneuropathy and Charcot Neuro-osteoarthropathy: Response to Intracutaneous Candida Albicans Completed NCT01370837
10 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Completed NCT02316483
11 Assessment of Surgical Correction of Deformity in Diabetic Charcot Arthropathy of the Foot and Ankle Not yet recruiting NCT04039308

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

40
Bone, Spinal Cord, Dorsal Root Ganglion, Kidney, Pancreas

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show top 50) (show all 264)
# Title Authors PMID Year
1
Surgical treatment of midfoot Charcot neuroarthropathy with osteomyelitis in patients with diabetes: a systematic review. 61
32530758 2020
2
History of etidronate. 61
31911206 2020
3
Charcot Reconstruction: Understanding and Treating the Deformed Charcot Neuropathic Arthropathic Foot. 61
32146981 2020
4
Non-infectious thoracic discitis: A diagnostic and management dilemma. A report of two cases with review of the literature. 61
31931336 2020
5
[From cellulitis to arthrodesis]. 61
32022495 2020
6
Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics. 61
30772132 2020
7
ACR Appropriateness Criteria® Suspected Osteomyelitis of the Foot in Patients With Diabetes Mellitus. 61
31685111 2019
8
Neuropathic Arthropathy of the Shoulder: A Systematic Review of Classifications and Treatments. 61
31663919 2019
9
Neuropathic Arthropathy of the Shoulder: A Systematic Review of Classifications and Treatments. 61
31574077 2019
10
[Neurogenic arthropathy of the lumbosacral spine:one case report and literature review]. 61
32512970 2019
11
Brachioradialis muscle flap for posterior elbow defects: a simple and effective solution for the upper limb surgeon. 61
31227467 2019
12
Neuropathic arthropathy of the shoulder joint caused by syringomyelia: report of a rare case. 61
30850574 2019
13
Imaging of Progressive Neuropathic Arthropathy of the Shoulder. 61
29979203 2019
14
Neuropathic arthropathy of the shoulder joint secondary to a syringomyelia. 61
30567186 2018
15
The Diagnostic Implications of Two Cases of Known Rheumatoid Arthritis from the CAL Milano Cemetery Skeletal Collection. 61
29684943 2018
16
Dynamic contrast-enhanced magnetic resonance imaging for differentiating osteomyelitis from acute neuropathic arthropathy in the complicated diabetic foot. 61
29654348 2018
17
Rapidly Destructive Arthrosis of Bilateral Humeral Heads Caused by Subchondral Insufficiency Fracture. 61
30369611 2018
18
Charcot arthropathy of the shoulder joint as a presenting feature of basilar impression with syringomyelia: A case report and literature review. 61
29995782 2018
19
Neuropathic Arthropathy of the Glenohumeral Joint A Review of the Literature. 61
29799367 2018
20
[Charcot foot masked by erysipelas and peripheral arterial disease]. 61
29184984 2018
21
Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. 61
29058098 2018
22
Diabetic foot syndrome: Charcot arthropathy or osteomyelitis? Part I: Clinical picture and radiography. 61
29844940 2018
23
Diabetic Neuropathic Arthropathy of the Knee: Two Case Reports and a Review of the Literature. 61
29610694 2018
24
Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot. 61
28696850 2017
25
Multifocal neuropathic arthropathy in patient with undiagnosed neurosyphilis: A case report. 61
27810982 2017
26
Effectiveness of Hindfoot Arthrodesis by Stable Internal Fixation in Various Eichenholtz Stages of Neuropathic Ankle Arthropathy. 61
28110796 2017
27
Charcot arthropathy of the knee after unsuccessful spinal stenosis surgery: A case report. 61
28511074 2017
28
Outcome after protected full weightbearing treatment in an orthopedic device in diabetic neuropathic arthropathy (Charcot arthropathy): a comparison of unilaterally and bilaterally affected patients. 61
28031030 2016
29
A rare case of idiopathic thumb CMC joint neuropathic arthropathy complicated by blunt trauma. 61
28018094 2016
30
Syringomyelic Neuropathic Arthropathy of the Elbow. 61
27736857 2016
31
The Charcot foot: pathophysiology, diagnosis and classification. 61
27587513 2016
32
Rheumatoid arthritis and tabetic arthropathy: physiopathological link or simple association? 61
27708969 2016
33
Neuropathic arthropathy of the elbow treated with double-plate arthrodesis and resection site bone graft. 61
27583001 2016
34
Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience. 61
27656656 2016
35
[Charcot arthropathy and diabetic foot]. 61
27627777 2016
36
Unilateral neuropathic arthropathy of the shoulder secondary to syringomyelia: Diagnostic challenges. 61
26677453 2015
37
Factors Affecting the Outcomes of Uncomplicated Primary Open Ankle Arthrodesis. 61
25994833 2015
38
Sensory manifestations of diabetic neuropathies: anatomical and clinical correlations. 61
25614497 2015
39
Pediatric neuropathic arthropathy initially masquerading as inflammatory arthritis. 61
25275767 2014
40
A rare case of ipsilateral shoulder and thumb CMC joint neuropathic arthropathy. 61
24914106 2014
41
Neuropathic arthropathy and syringomyelia complicating a case of ankylosing spondylitis with peripheral arthritis. 61
24957593 2014
42
A case report of Charcot arthropathy caused by syringomyelia and Chiari malformation complicated with scoliosis. 61
24886292 2014
43
Charcot's Elbow Following Syringomyelia: Revisited. 61
26905711 2014
44
Outpatient assessment and management of the diabetic foot. 61
24559880 2014
45
An unusual presentation of charcot arthropathy caused by syringomyelia mimicking a soft tissue tumor. 61
25126434 2014
46
Charcot arthropathy of the shoulder associated with typical and atypical findings. 61
22696209 2013
47
Assessing decreased sensation and increased sensory phenomena in diabetic polyneuropathies. 61
24158999 2013
48
Who was first to diagnose and report neuropathic arthropathy of the foot and ankle: Jean-Martin Charcot or Herbert William Page? 61
23765185 2013
49
Bilateral ulnar neuropathy at the elbow secondary to neuropathic arthropathy associated with syringomyelia. 61
23790822 2013
50
Neuropathic arthropathy caused by syringomyelia. 61
23289508 2013

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

Pathways related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
9.66 NTRK1 NGF

GO Terms for Neurogenic Arthropathy

Cellular components related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 NGF INS

Biological processes related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.56 SCX NGF INS CRP
2 cellular response to nerve growth factor stimulus GO:1990090 9.46 NTRK1 CALCA
3 acute-phase response GO:0006953 9.43 INS CRP
4 positive regulation of Ras protein signal transduction GO:0046579 9.4 NTRK1 NGF
5 positive regulation of blood vessel diameter GO:0097755 9.37 INS CALCA
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.32 NTRK1 NGF
7 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.16 NTRK1 CALCA
8 nerve growth factor signaling pathway GO:0038180 8.96 NTRK1 NGF
9 negative regulation of blood vessel diameter GO:0097756 8.62 INS CRP

Molecular functions related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 N-acetyltransferase activity GO:0008080 9.16 NAA50 NAA30
2 transferase activity, transferring acyl groups GO:0016746 9.13 SPTLC1 NAA50 NAA30
3 peptide alpha-N-acetyltransferase activity GO:0004596 8.62 NAA50 NAA30

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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