MCID: NRG001
MIFTS: 33

Neurogenic Bowel

Categories: Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Bowel

MalaCards integrated aliases for Neurogenic Bowel:

Name: Neurogenic Bowel 12 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13419
ICD9CM 36 564.81
MeSH 45 D055496
ICD10 34 K59.2
UMLS 74 C0695242

Summaries for Neurogenic Bowel

MalaCards based summary : Neurogenic Bowel is related to spinal cord injury and dental abscess. An important gene associated with Neurogenic Bowel is LMNB1 (Lamin B1). The drugs Glycerol and Cola have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, colon and testis.

Wikipedia : 77 Neurogenic bowel dysfunction (NBD) is the inability to control defecation due to a nervous system... more...

Related Diseases for Neurogenic Bowel

Graphical network of the top 20 diseases related to Neurogenic Bowel:



Diseases related to Neurogenic Bowel

Symptoms & Phenotypes for Neurogenic Bowel

Drugs & Therapeutics for Neurogenic Bowel

Drugs for Neurogenic Bowel (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2 Cola Phase 4,Not Applicable
3 Protective Agents Phase 4
4 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
5
Oxycodone Approved, Illicit, Investigational Phase 3 76-42-6 5284603
6
Naloxone Approved, Vet_approved Phase 3 465-65-6 5284596
7 Peripheral Nervous System Agents Phase 3,Phase 1,Early Phase 1
8 Gentamicins Phase 2, Phase 3
9 Anti-Infective Agents Phase 2, Phase 3
10 Anti-Bacterial Agents Phase 2, Phase 3
11 Analgesics Phase 3
12 Analgesics, Opioid Phase 3
13 Central Nervous System Depressants Phase 3
14 Narcotic Antagonists Phase 3
15 Narcotics Phase 3
16
Neostigmine Approved, Vet_approved Phase 1,Early Phase 1 59-99-4 4456
17 Anesthetics Phase 1,Early Phase 1
18 Cholinesterase Inhibitors Phase 1,Early Phase 1
19 Neurotransmitter Agents Phase 1,Early Phase 1
20 Adjuvants, Anesthesia Phase 1,Early Phase 1
21 Muscarinic Antagonists Phase 1,Early Phase 1
22
Glycopyrrolate Phase 1,Early Phase 1 596-51-0 3494
23 Cholinergic Agents Phase 1,Early Phase 1
24 Cholinergic Antagonists Phase 1,Early Phase 1
25 Autonomic Agents Phase 1,Early Phase 1
26
Norepinephrine Approved Not Applicable 51-41-2 439260
27
Racepinephrine Approved Not Applicable 329-65-7 838
28
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
29
Mirabegron Approved Early Phase 1 223673-61-8 9865528
30 Epinephryl borate Not Applicable
31 Cathartics Not Applicable
32 Laxatives Not Applicable
33 Adrenergic Agonists Early Phase 1
34 Adrenergic beta-3 Receptor Agonists Early Phase 1
35 Adrenergic Agents Early Phase 1
36 Adrenergic beta-Agonists Early Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury Completed NCT00286520 Phase 4
2 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Recruiting NCT02435069 Phase 4 NS and USP Glycerin - Dose Response;NS and USP Glycerin - Effectiveness
3 Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury Active, not recruiting NCT03503513 Phase 2, Phase 3 Gentamicin Sulfate;Saline
4 Targin® for Chronic Pain Management in Patients With Spinal Cord Injury Not yet recruiting NCT03179475 Phase 3 Oxycodone Naloxone Combination
5 Use of Prokinetics During Inpatient Bowel Care for SCI Patients Recruiting NCT02370433 Phase 1 Intravenous Neostigmine and Glycopyrrolate;Transdermal Neostigmine and Glycopyrrolate
6 Abdominal Massage for Bowel Dysfunction Completed NCT03166007 Not Applicable
7 Evaluation of a Novel Electronic Transanal Irrigation System - Navina™ Smart Completed NCT02709395 Not Applicable
8 Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI Completed NCT02370862 Early Phase 1 Neostigmine and Glycopyrrolate
9 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
10 Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation Completed NCT03458871 Not Applicable
11 Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI) Completed NCT01920243 Not Applicable
12 Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI Completed NCT02406859 Not Applicable
13 Autonomic Dysreflexia in Spinal Cord Injury Completed NCT01059370 Not Applicable
14 Retrograde Colonic Irrigation to Manage Spina Bifida Functional Digestive Sequelae: a Multicenter, Prospective, Randomized Controlled Trial Recruiting NCT02361450 Not Applicable
15 Contribution of Percutaneous Endoscopic Caecostomie in the Management of Severe Constipation Refractory to Medical Treatment Recruiting NCT02566746 Not Applicable continuation of optimal medical therapy
16 An Open, Qualitative, Prospective, Multicenter Trial of a Novel Transanal Irrigation System in Spinal Cord Injured Patients. Active, not recruiting NCT02979808 Not Applicable
17 Spinal Cord Injury Epidural Stimulation Active, not recruiting NCT02592668 Not Applicable
18 BLB Study Back or Leg Pain and Bladder Symptoms Study Active, not recruiting NCT03325374
19 Stimulation for Colonic Motility Enrolling by invitation NCT02641483 Not Applicable
20 Treatment of Spinal Cord Injury Patients for Neurogenic Bladder: Anticholinergic Agent vs. Mirabegron Enrolling by invitation NCT03612401 Early Phase 1 Mirabegron
21 Transcutaneous and Epidural Spinal Stimulation for Enabling Motor Function in Humans With Motor Complete Paraplegia Enrolling by invitation NCT03945331 Not Applicable
22 Improving Bowel Function and Quality of Life After Spinal Cord Injury Not yet recruiting NCT03949660 Not Applicable
23 Spinal Cord Stimulation and Autonomic Response in People With SCI. Not yet recruiting NCT03924388 Not Applicable

Search NIH Clinical Center for Neurogenic Bowel

Cochrane evidence based reviews: neurogenic bowel

Genetic Tests for Neurogenic Bowel

Anatomical Context for Neurogenic Bowel

MalaCards organs/tissues related to Neurogenic Bowel:

42
Spinal Cord, Colon, Testis, Ovary

Publications for Neurogenic Bowel

Articles related to Neurogenic Bowel:

(show top 50) (show all 103)
# Title Authors Year
1
Anti-muscarinic drugs increase rectal compliance and exacerbate constipation in chronic spinal cord injury : Anti-muscarinic drug effect on neurogenic bowel. ( 30804425 )
2019
2
Investigating neurogenic bowel in experimental spinal cord injury: where to begin? ( 30531001 )
2019
3
Identifying and Classifying Quality of Life Tools for Assessing Neurogenic Bowel Dysfunction After Spinal Cord Injury. ( 30774286 )
2019
4
Neurogenic bowel dysfunction in patients with multiple sclerosis: prevalence, impact, and management strategies. ( 30584387 )
2018
5
Neurogenic bowel dysfunction: Clinical management recommendations of the Neurologic Incontinence Committee of the Fifth International Consultation on Incontinence 2013. ( 28640977 )
2018
6
Effect of quantitative assessment-based nursing intervention on the bowel function and life quality of patients with neurogenic bowel dysfunction after spinal cord injury. ( 29193471 )
2018
7
Response to "The neurogenic bowel dysfunction score in patients with spinal cord injury: methodological issues in reliability and validity". ( 29348689 )
2018
8
The neurogenic bowel dysfunction score in patients with spinal cord injury: methodological issues in reliability and validity. ( 29348690 )
2018
9
International standards to document remaining autonomic Function in persons with SCI and neurogenic bowel dysfunction: Illustrative cases. ( 29423306 )
2018
10
Experience of Nurses Caring for Patients With Neurogenic Bowel Dysfunction: A Qualitative Study. ( 29521927 )
2018
11
Assessment of neurogenic bowel dysfunction impact after spinal cord injury using the International Classification of Functioning, Disability and Health. ( 29745625 )
2018
12
Neurogenic bowel management for the adult spinal cord injury patient. ( 29951791 )
2018
13
A systematic review of clinical studies on electrical stimulation therapy for patients with neurogenic bowel dysfunction after spinal cord injury. ( 30313096 )
2018
14
Abdominal massage plus advice, compared with advice only, for neurogenic bowel dysfunction in MS: a RCT. ( 30375324 )
2018
15
Objective demonstration of improvement of neurogenic bowel dysfunction in a case of spinal cord injury following stem cell therapy. ( 30443317 )
2018
16
Chronic refractory constipation due to neurogenic bowel dysfunction can be successfully treated by sacral neurostimulation. ( 28467281 )
2018
17
Long-Term Outcomes and Longitudinal Changes of Neurogenic Bowel Management in Adults With Pediatric-Onset Spinal Cord Injury. ( 27473299 )
2017
18
Ageing with neurogenic bowel dysfunction. ( 28290468 )
2017
19
Abdominal massage for neurogenic bowel dysfunction in people with multiple sclerosis (AMBER - Abdominal Massage for Bowel Dysfunction Effectiveness Research): study protocol for a randomised controlled trial. ( 28356133 )
2017
20
3T MR-defecography-A feasibility study in sensorimotor complete spinal cord injured patients with neurogenic bowel dysfunction. ( 28629562 )
2017
21
Reliability, validity and sensitivity to change of neurogenic bowel dysfunction score in patients with spinal cord injury. ( 28695900 )
2017
22
Variation in surgical management of neurogenic bowel among centers participating in National Spina Bifida Patient Registry. ( 29125521 )
2017
23
Prospective evaluation of Peristeen® transanal irrigation system with the validated neurogenic bowel dysfunction score sheet in the pediatric population. ( 26879474 )
2017
24
Neurogenic Bowel Dysfunction in Patients with Neurogenic Bladder. ( 28717406 )
2016
25
Evidence base for managing neurogenic bowel dysfunction. ( 27491188 )
2016
26
Long-Term Cost-Effectiveness of Transanal Irrigation in Patients with Neurogenic Bowel Dysfunction. ( 27557052 )
2016
27
Effects and Safety of Aqueous Extract of Poncirus fructus in Spinal Cord Injury with Neurogenic Bowel. ( 27738444 )
2016
28
What is the best way to manage neurogenic bowel dysfunction? ( 27815246 )
2016
29
Palliation of Neurogenic Bowel #317. ( 27841955 )
2016
30
Self-Report of Behaviors to Manage Neurogenic Bowel and Bladder by Individuals with Chronic Spinal Cord Injury: Frequency and Associated Outcomes. ( 29339851 )
2016
31
Neurogenic bowel dysfunction (NBD) translation and linguistic validation to classical Arabic. ( 27449575 )
2016
32
Electroacupuncture at Zusanli (ST36) ameliorates colonic neuronal nitric oxide synthase upregulation in rats with neurogenic bowel dysfunction following spinal cord injury. ( 27377302 )
2016
33
Anorectal biofeedback for neurogenic bowel dysfunction in incomplete spinal cord injury. ( 27184916 )
2016
34
Medical and surgical management of neurogenic bowel. ( 27152922 )
2016
35
Risk Factors Associated With Neurogenic Bowel Complications and Dysfunction in Spinal Cord Injury. ( 27109330 )
2016
36
Managing neurogenic bowel dysfunction: what do patients prefer? A discrete choice experiment of patient preferences for transanal irrigation and standard bowel management. ( 26937179 )
2016
37
Ultrasonic measurement of rectal diameter and area in neurogenic bowel with spinal cord injury. ( 25432419 )
2016
38
Development, reliability and validation of a neurogenic bowel dysfunction score in pediatric patients with spina bifida. ( 25400229 )
2016
39
Long-Term Cost-Effectiveness of Transanal Irrigation In Patients With Neurogenic Bowel Dysfunction Who Have Failed Standard Bowel Care. ( 26532036 )
2015
40
Outcomes of bowel program in spinal cord injury patients with neurogenic bowel dysfunction. ( 26330842 )
2015
41
Outcomes of neurogenic bowel management in individuals living with a spinal cord injury for at least 10 years. ( 25620716 )
2015
42
Neurogenic bowel after spinal cord injury from the perspective of support providers: a phenomenological study. ( 25305370 )
2015
43
Phenomenological study of neurogenic bowel from the perspective of individuals living with spinal cord injury. ( 25172370 )
2015
44
Development of hydronephrosis secondary to poorly managed neurogenic bowel requiring surgical disimpaction in a patient with spinal cord injury: a case report. ( 24617444 )
2014
45
Hydronephrosis: an unusual complication of neurogenic bowel in a patient with spinal cord injury: a case report. ( 24902647 )
2014
46
Comparison of efficacies of vegetable oil based and polyethylene glycol based bisacodyl suppositories in treating patients with neurogenic bowel dysfunction after spinal cord injury: a meta-analysis. ( 25417608 )
2014
47
Parents of children with neurogenic bowel dysfunction: their experiences of using transanal irrigation with their child. ( 24261461 )
2014
48
Pudendal nerve stimulation: a potential tool for neurogenic bowel dysfunction! ( 23804532 )
2014
49
Independence does not come with the method--treatment of neurogenic bowel dysfunction in children with myelomeningocele. ( 25048689 )
2014
50
Abdominal Pain: A Comparison between Neurogenic Bowel Dysfunction and Chronic Idiopathic Constipation. ( 24159329 )
2013

Variations for Neurogenic Bowel

Expression for Neurogenic Bowel

Search GEO for disease gene expression data for Neurogenic Bowel.

Pathways for Neurogenic Bowel

GO Terms for Neurogenic Bowel

Cellular components related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CA2 HAMP KIT LY86 LY96 PTGIS

Biological processes related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to zinc ion GO:0010043 9.16 CA2 HAMP
2 cellular response to interleukin-6 GO:0071354 8.96 HAMP PTGIS
3 positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 8.62 LY86 LY96

Sources for Neurogenic Bowel

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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