MCID: NRG001
MIFTS: 31

Neurogenic Bowel

Categories: Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Bowel

MalaCards integrated aliases for Neurogenic Bowel:

Name: Neurogenic Bowel 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13419
ICD9CM 34 564.81
MeSH 44 D055496
SNOMED-CT 67 425671009
ICD10 32 K59.2
UMLS 70 C0695242

Summaries for Neurogenic Bowel

MalaCards based summary : Neurogenic Bowel is related to constipation and irritable bowel syndrome. An important gene associated with Neurogenic Bowel is MLN (Motilin), and among its related pathways/superpathways is Gastric acid production. The drugs Glycerol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, colon and appendix.

Wikipedia : 73 Neurogenic bowel dysfunction (NBD) is the inability to control defecation due to a nervous system... more...

Related Diseases for Neurogenic Bowel

Diseases related to Neurogenic Bowel via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 constipation 30.4 VIP TAC1 MLN GAST
2 irritable bowel syndrome 29.7 VIP TAC1 MLN
3 diarrhea 29.4 TAC1 MLN GAST
4 spinal cord injury 10.8
5 neural tube defects 10.4
6 myelomeningocele 10.4
7 ileus 10.2 VIP MLN
8 colonic pseudo-obstruction 10.2 MLN ACHE
9 persian gulf syndrome 10.2 VIP ACHE
10 neurogenic bladder 10.2
11 binswanger's disease 10.2 VIP ACHE
12 anismus 10.1 VIP TAC1
13 intracranial vasospasm 10.1 VIP TAC1
14 facial dermatosis 10.1 VIP TAC1
15 vasomotor rhinitis 10.1 VIP TAC1
16 multiple sclerosis 10.1
17 paraplegia 10.1
18 intestinal obstruction 10.1 MLN ACHE
19 postcholecystectomy syndrome 10.1 MLN GAST
20 postgastrectomy syndrome 10.1 MLN GAST
21 cryptosporidiosis 10.1 VIP TAC1
22 rectum neuroendocrine neoplasm 10.1 VIP GAST
23 endocrine pancreas disease 10.1 VIP GAST
24 glucagonoma 10.1 VIP GAST
25 hernia, hiatus 10.1 MLN GAST
26 peptic esophagitis 10.1 MLN GAST
27 urinary tract infection 10.0
28 acute cystitis 10.0
29 pancreatic cholera 10.0 VIP GAST
30 colon neuroendocrine neoplasm 10.0 VIP GAST
31 bile reflux 10.0 MLN GAST
32 duodenogastric reflux 10.0 MLN GAST
33 diabetic autonomic neuropathy 10.0 MLN GAST
34 autonomic neuropathy 10.0 MLN GAST
35 dumping syndrome 10.0 MLN GAST
36 megacolon 10.0 VIP ACHE
37 hypertrophic pyloric stenosis 10.0 MLN GAST
38 appendix lymphoma 10.0 TAC1 GAST
39 pyloric stenosis 10.0 MLN GAST
40 vipoma 10.0 VIP GAST
41 zollinger-ellison syndrome 10.0 MLN GAST
42 somatostatinoma 10.0 VIP GAST
43 intestinal pseudo-obstruction 10.0 VIP MLN ACHE
44 serotonin syndrome 10.0 TAC1 GAST
45 paralytic ileus 10.0 VIP TAC1 MLN
46 pancreatic cystadenoma 10.0 VIP GAST
47 hydronephrosis 10.0
48 quadriplegia 10.0
49 gastrinoma 10.0 VIP GAST
50 gastroparesis 9.9 MLN GAST

Graphical network of the top 20 diseases related to Neurogenic Bowel:



Diseases related to Neurogenic Bowel

Symptoms & Phenotypes for Neurogenic Bowel

Drugs & Therapeutics for Neurogenic Bowel

Drugs for Neurogenic Bowel (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2 Pharmaceutical Solutions Phase 4
3 Protective Agents Phase 4
4 Cola Phase 3
5 Bifidobacterium Phase 3
6
Neostigmine Approved, Vet_approved Phase 1 59-99-4 4456
7 Cholinesterase Inhibitors Phase 1
8 Cholinergic Agents Phase 1
9 Cholinergic Antagonists Phase 1
10 Anesthetics Phase 1
11 Muscarinic Antagonists Phase 1
12 Neurotransmitter Agents Phase 1
13
Glycopyrrolate Phase 1 596-51-0 3494
14 Cathartics
15 Laxatives

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Completed NCT02435069 Phase 4 Dose Response - NS and USP Glycerin - First Intervention;Effectiveness - NS and USP Glycerin - Second Intervention
2 Use of Novel Human Milk Prebiotics to Improve the Quality of Life for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction Recruiting NCT03987126 Phase 3
3 Use of Prokinetics During Inpatient Bowel Care for SCI Patients Unknown status NCT02370433 Phase 1 Intravenous Neostigmine and Glycopyrrolate;Transdermal Neostigmine and Glycopyrrolate
4 Evaluation of a Novel Electronic Transanal Irrigation System - Navina™ Smart Completed NCT02709395
5 An Open, Qualitative, Prospective, Multicenter Trial of a Novel Transanal Irrigation System in Spinal Cord Injured Patients. Completed NCT02979808
6 Abdominal Massage for Neurogenic Bowel Dysfunction in People With Multiple Sclerosis (AMBER Abdominal Massage for Bowel Dysfunction Effectiveness Research). Completed NCT03166007
7 Applying Health Mechanics to Enhance Bowel and Bladder Health for Persons With SCI Completed NCT01920243
8 Bowel Biofeedback Training to Improve Bowel Function in Individuals With SCI Completed NCT02406859
9 Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation Completed NCT03458871
10 A Novel Application of Iontophoresis in the Transcutaneous Delivery of a Prokinetic Agent for the Promotion of Bowel Evacuation Completed NCT02370862 Early Phase 1 Neostigmine and Glycopyrrolate
11 Targeting Improvements in Bowel Function and Quality of Life Using Epidural Stimulation and Training After Severe Spinal Cord Injury Recruiting NCT03949660
12 Neurogenic Bowel Dysfunction: Evaluation of the Effects of Osteopathic Manipulative Treatment in People With Central Nervous System Injury Recruiting NCT04127617
13 The Effects of Osteopathic Manipulative Treatments on Neurogenic Bowel Dysfunction in Patients With Spinal Cord Injuries: a Randomized Manual Placebo Controlled Trial Recruiting NCT04367571
14 A Randomized Controlled Trial Comparing the Efficacy of Transanal Irrigation With Navina Smart Versus Standard Bowel Care in Patients With Multiple Sclerosis Active, not recruiting NCT04707976
15 Afferent Stimulation to Evoke Recto-colonic Reflex for Colonic Motility Enrolling by invitation NCT02641483
16 A Randomised Sham-controlled, Proof of Principle Study of Abdominal Functional Electrical Stimulation (ABFES) for Bowel Management in Spinal Cord Injury (SCI) Not yet recruiting NCT04307303
17 The Role of Active Administration of Peristeen Bowel Evacuation for the Management of Urinary Tract Infection in Patients With Neurogenic Bladder: a Prospective, Explorative Pilot Study Not yet recruiting NCT04815226
18 Motor and Autonomic Concomitant Health Improvements With Neuromodulation and Exoskeleton (MACHINE) Training: A Randomized Controlled Trial in Individuals With SCI Not yet recruiting NCT04726059
19 Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury Not yet recruiting NCT04604951

Search NIH Clinical Center for Neurogenic Bowel

Cochrane evidence based reviews: neurogenic bowel

Genetic Tests for Neurogenic Bowel

Anatomical Context for Neurogenic Bowel

MalaCards organs/tissues related to Neurogenic Bowel:

40
Spinal Cord, Colon, Appendix, Skin, Lung, Pancreas, Kidney

Publications for Neurogenic Bowel

Articles related to Neurogenic Bowel:

(show top 50) (show all 320)
# Title Authors PMID Year
1
Bowel Emptying Methods Used by German Residents Living With Spina Bifida. 61
33605711 2021
2
Validation of the Monitoring Efficacy of Neurogenic Bowel Treatment on Response (MENTOR) Tool in a Japanese Rehabilitation Setting. 61
33804312 2021
3
Context for Practice: Medical Device-Related Pressure Injuries, Neurogenic Bowel Management, Risk Factors for Lower Extremity Amputation, and Innovative Approach to Ostomy Accessory Product. 61
33690242 2021
4
The Addition of Transdermal Delivery of Neostigmine and Glycopyrrolate by Iontophoresis to Thrice Weekly Bowel Care in Persons with Spinal Cord Injury: A Pilot Study. 61
33800503 2021
5
Factors Associated with Recovery in Motor Strength, Walking Ability, and Bowel and Bladder Function after Traumatic Cauda Equina Injury. 61
32907483 2021
6
Transanal Irrigation for Neurogenic Bowel Disease, Low Anterior Resection Syndrome, Faecal Incontinence and Chronic Constipation: A Systematic Review. 61
33668658 2021
7
Troubleshooting problems with antegrade continent enema flushes: The Indiana university algorithm. 61
33707132 2021
8
Small intestinal bacterial overgrowth in spinal cord injury patients. 61
33640466 2021
9
Civilian Gun Shot Wounds Associated With Spinal Injuries. 61
33567932 2021
10
Spinal cord injuries and bowel stomas: timing and satisfaction with stoma formation and alterations in quality of life. 61
33536415 2021
11
[The paraplegic patient-Characteristics of diagnostics and treatment in visceral surgery]. 61
33630122 2021
12
The Effect of Sacral Neuromodulation in Ambulatory Spina Bifida Patients with Neurogenic Bladder and Bowel Dysfunction. 61
33556449 2021
13
The effect of the therapy of "combination 3 methods progression" in patients with neurogenic bowel dysfunction (constipated type): Study protocol for a randomized controlled trial. 61
33607803 2021
14
Lower urinary tract and bowel dysfunction in spinocerebellar ataxias. 61
33338328 2021
15
Dietary Intakes and Food Habits of Wheelchair Basketball Athletes compared to Gym Attendees and Individuals who do not Practice Sport Activity. 61
33563163 2021
16
Pharmacological Management of Neurogenic Bowel Dysfunction after Spinal Cord Injury and Multiple Sclerosis: A Systematic Review and Clinical Implications. 61
33671492 2021
17
Enterococcus faecalis infective endocarditis arising from chronic rectal prolapse in the setting of spinal cord injury. 61
33558386 2021
18
Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida. 61
33435163 2021
19
Utility estimation for neurogenic bowel dysfunction in the general population. 61
33612400 2021
20
An open prospective study on the efficacy of Navina Smart, an electronic system for transanal irrigation, in neurogenic bowel dysfunction. 61
33513187 2021
21
Efficacy and safety of alvimopan use in benign urinary tract reconstruction. 61
32869174 2021
22
The Monitoring Efficacy of Neurogenic Bowel Dysfunction Treatment on Response (MENTOR) in a Non-Hospital Setting. 61
33445668 2021
23
Safety and Efficacy of Intermittent Colonic Exoperistalsis Device to Treat Chronic Constipation: A Prospective Multicentric Clinical Trial. 61
33512794 2020
24
Electrical Colon Stimulation Reflexively Increases Colonic Activity. 61
31418508 2020
25
Use of Malone antegrade continence enemas in neurologic bowel dysfunction. 61
32247623 2020
26
Treatments in neurogenic bowel dysfunctions: evidence reviews and clinical recommendations in adults. 61
32935955 2020
27
Quantitative assessment-based nursing intervention improves bowel function in patients with neurogenic bowel dysfunction after spinal cord injury: Study protocol for a randomized controlled study. 61
33371066 2020
28
Electro-Neuromodulation for Colonic Disorders-Review of Meta-Analyses, Systematic Reviews, and RCTs. 61
32017319 2020
29
Treatment options and long-term outcomes in pediatric spinal cord vascular malformations: a case report and review of the literature. 61
32377828 2020
30
Effectiveness of percutaneous posterior tibial nerve stimulation for the management of bowel dysfunction in multiple sclerosis patients. 61
33179574 2020
31
Factors associated with ultrasound diagnosed neurogenic bladder complications following spinal cord injury. 61
33219171 2020
32
Development of a novel neurogenic bowel patient reported outcome measure: the Spinal Cord Injury Patient Reported Outcome Measure of Bowel Function & Evacuation (SCI-PROBE). 61
32393796 2020
33
Prenatal diagnosis of Fetal notochord syndrome: A case report and review of the literature. 61
33163368 2020
34
Spanish validation of the Neurogenic Bowel Dysfunction score -NBD score- in patients with central neurological injury. 61
33039135 2020
35
Diminished enteric neuromuscular transmission in the distal colon following experimental spinal cord injury. 61
32526238 2020
36
[Guidelines: neurogenic bowel dysfunction in spinal cord injury (long version)]. 61
32934429 2020
37
Pediatric Neurogenic Bladder and Bowel Dysfunction: Will My Child Ever Be out of Diapers? 61
31982364 2020
38
Impact of Transanal Irrigation Device in the Management of Children With Fecal Incontinence and Constipation. 61
32404764 2020
39
Neurogenic Bowel Management Using Transanal Irrigation by Persons with Spinal Cord Injury. 61
32624096 2020
40
Management Strategies for Spinal Cord Injury Pain Updated for the Twenty-First Century. 61
32624100 2020
41
"Imola-Montecatone" subtotal colectomy to improve bowel management in spinal cord injury patients. Retrospective analysis in 19 cases. 61
32636361 2020
42
Creation and validation of a new tool for the monitoring efficacy of neurogenic bowel dysfunction treatment on response: the MENTOR tool. 61
31988365 2020
43
Effect of sacral neuromodulation on bowel dysfunction in patients with neurogenic bladder. 61
32681678 2020
44
Assessment of neurogenic bowel symptoms with the bowel dysfunction score in children with spina bifida: a prospective case-control study. 61
32405766 2020
45
Continuation of Neurogenic Bowel and Bladder Programs in a Pancytopenic Cancer Patient: A Case Report. 61
32602590 2020
46
Diet in neurogenic bowel management: A viewpoint on spinal cord injury. 61
32523306 2020
47
A therapeutic effect for males with spinal cord injury using abdominal functional electrical stimulation for sexual functioning. 61
32317626 2020
48
Neurogenic bowel and bladder evaluation strategies in spinal cord injury: New directions. 61
32105585 2020
49
Cancer Rehabilitation:: Acute and Chronic Issues, Nerve Injury, Radiation Sequelae, Surgical and Chemo-Related, Part 2. 61
32035567 2020
50
Recommendations for evaluation of neurogenic bladder and bowel dysfunction after spinal cord injury and/or disease. 61
32105586 2020

Variations for Neurogenic Bowel

Expression for Neurogenic Bowel

Search GEO for disease gene expression data for Neurogenic Bowel.

Pathways for Neurogenic Bowel

Pathways related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 VIP GAST

GO Terms for Neurogenic Bowel

Cellular components related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 VIP TAC1 MLN GAST ACHE

Biological processes related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 8.92 VIP TAC1 MLN GAST

Molecular functions related to Neurogenic Bowel according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 VIP MLN GAST

Sources for Neurogenic Bowel

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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