MCID: NRG005
MIFTS: 28

Neurogenic Hypertension

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Hypertension

MalaCards integrated aliases for Neurogenic Hypertension:

Name: Neurogenic Hypertension 53 73

Classifications:



External Ids:

UMLS 73 C0597048

Summaries for Neurogenic Hypertension

MalaCards based summary : Neurogenic Hypertension is related to neuronitis and cervicitis. An important gene associated with Neurogenic Hypertension is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways are Peptide hormone metabolism and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Minocycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and kidney.

Related Diseases for Neurogenic Hypertension

Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 neuronitis 10.0
2 cervicitis 9.9
3 cerebritis 9.8
4 thyroiditis 9.6
5 depression 9.6
6 hypoxia 9.6
7 syncope 9.6
8 apnea, obstructive sleep 9.6
9 diabetes mellitus, noninsulin-dependent 9.6
10 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.6
11 sleep apnea 9.6
12 renal hypertension 9.6
13 cerebral atherosclerosis 9.6
14 porphyria 9.6
15 posterior urethral valves 9.2 ACE2 AGTR1
16 hypertension, essential 9.1 ACE2 AGTR1
17 pre-eclampsia 9.0 AGTR1 ENPEP

Graphical network of the top 20 diseases related to Neurogenic Hypertension:



Diseases related to Neurogenic Hypertension

Symptoms & Phenotypes for Neurogenic Hypertension

Drugs & Therapeutics for Neurogenic Hypertension

Drugs for Neurogenic Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 1, Phase 2 10118-90-8 5281021
2 Anti-Bacterial Agents Phase 1, Phase 2
3 Anti-Infective Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Recruiting NCT02133885 Phase 1, Phase 2 Minocycline Group
2 Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Recruiting NCT02133872 Phase 1 Minocycline 100mg Group;Minocycline 200mg Group

Search NIH Clinical Center for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

Anatomical Context for Neurogenic Hypertension

MalaCards organs/tissues related to Neurogenic Hypertension:

41
Brain, Medulla Oblongata, Kidney, Heart, Hypothalamus, Pons, Thyroid

Publications for Neurogenic Hypertension

Articles related to Neurogenic Hypertension:

(show top 50) (show all 148)
# Title Authors Year
1
Neurogenic hypertension: pathophysiology, diagnosis and management. ( 29974290 )
2018
2
Exaggerated Sympathetic Neurovascular Transduction as a Mechanism of Neurogenic Hypertension: It Is Not All About Activity. ( 29203626 )
2018
3
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension. ( 28512108 )
2017
4
Mitochondria and Reactive Oxygen Species Contribute to Neurogenic Hypertension. ( 28615314 )
2017
5
Kinin B1 Receptor Promotes Neurogenic Hypertension Through Activation of Centrally Mediated Mechanisms. ( 29038201 )
2017
6
Recent Advances in Neurogenic Hypertension: Dietary Salt, Obesity, and Inflammation. ( 28739972 )
2017
7
Neurogenic hypertension and the secrets of respiration. ( 28438764 )
2017
8
Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance. ( 28754499 )
2017
9
Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia. ( 27895191 )
2017
10
Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats. ( 28720883 )
2017
11
Transcriptional networks in rodent models support a role for gut-brain communication in neurogenic hypertension: a review of the evidence. ( 28550087 )
2017
12
Contribution of Orexin to the Neurogenic Hypertension in BPH/2J Mice. ( 26975709 )
2016
13
Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. ( 27754863 )
2016
14
OS 25-02 ORIGIN OF NEUROGENIC HYPERTENSION AND THE SYMPATHO-EXCITATION IN DIET INDUCED OBESITY. ( 27643054 )
2016
15
Furosemide modifies heart hypertrophy and glycosaminoglycan myocardium content in a rat model of neurogenic hypertension. ( 27221775 )
2016
16
OS 25-02 ORIGIN OF NEUROGENIC HYPERTENSION AND THE SYMPATHO-EXCITATION IN DIET INDUCED OBESITY. ( 27754127 )
2016
17
I+-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. ( 26254330 )
2015
18
Carotid body over activity induces respiratory neurone channelopathy contributing to neurogenic hypertension. ( 25900825 )
2015
19
Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. ( 25489058 )
2015
20
In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. ( 26834545 )
2015
21
Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension. ( 24987020 )
2014
22
Different impacts of I+- and I^-blockers in neurogenic hypertension produced by brainstem lesions in rat. ( 24614323 )
2014
23
Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. ( 24688126 )
2014
24
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. ( 24014829 )
2013
25
Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. ( 24275840 )
2013
26
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. ( 23747290 )
2013
27
The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. ( 24002774 )
2013
28
Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats. ( 22746319 )
2013
29
Stabilization of hypoxia inducible factor-1I+ ameliorates acute renal neurogenic hypertension. ( 24309492 )
2013
30
Neurogenic hypertension: revelations from genome-wide gene expression profiling. ( 22639016 )
2012
31
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? ( 22562144 )
2012
32
Chiari I malformation with neurogenic hypertension: case report. ( 22890471 )
2012
33
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. ( 22958438 )
2012
34
Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension. ( 21755262 )
2011
35
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. ( 21487032 )
2011
36
Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension. ( 21536990 )
2011
37
Contributions of vascular inflammation in the brainstem for neurogenic hypertension. ( 21601658 )
2011
38
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. ( 21445721 )
2011
39
Brain microglial cytokines in neurogenic hypertension. ( 20547972 )
2010
40
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The kidney is not always the target in neurogenic hypertension. ( 21188820 )
2010
41
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. ( 19923158 )
2010
42
Inflammation and neurogenic hypertension: a new role for the circumventricular organs? ( 20651292 )
2010
43
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. ( 19926873 )
2010
44
Neurogenic hypertension. ( 20407134 )
2010
45
Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. ( 19762685 )
2009
46
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? ( 19413588 )
2009
47
Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. ( 19047792 )
2009
48
Is neurogenic hypertension related to vascular inflammation of the brainstem? ( 18585782 )
2009
49
Mitochondrial dysfunction and mitochondrial-produced reactive oxygen species: new targets for neurogenic hypertension? ( 19114641 )
2009
50
Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension. ( 19114648 )
2009

Variations for Neurogenic Hypertension

Expression for Neurogenic Hypertension

Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for Neurogenic Hypertension

GO Terms for Neurogenic Hypertension

Biological processes related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.4 ACE2 AGTR1
2 regulation of inflammatory response GO:0050727 9.37 ACE2 AGTR1
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.32 ACE2 AGTR1
4 regulation of vasoconstriction GO:0019229 9.26 ACE2 AGTR1
5 regulation of blood vessel diameter GO:0097746 9.16 ACE2 AGTR1
6 angiotensin maturation GO:0002003 8.96 ACE2 ENPEP
7 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE2 AGTR1 ENPEP

Molecular functions related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 8.62 ACE2 ENPEP

Sources for Neurogenic Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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