MCID: NRG005
MIFTS: 27

Neurogenic Hypertension

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neurogenic Hypertension

MalaCards integrated aliases for Neurogenic Hypertension:

Name: Neurogenic Hypertension 54 74

Classifications:



External Ids:

UMLS 74 C0597048

Summaries for Neurogenic Hypertension

MalaCards based summary : Neurogenic Hypertension is related to hypertension, essential and hypoxia. An important gene associated with Neurogenic Hypertension is ACE2 (Angiotensin I Converting Enzyme 2), and among its related pathways/superpathways is Peptide hormone metabolism. The drugs Minocycline and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and kidney.

Related Diseases for Neurogenic Hypertension

Diseases related to Neurogenic Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 28.8 ACE2 AGTR1
2 hypoxia 9.9
3 diabetes mellitus, noninsulin-dependent 9.8
4 neutrophil actin dysfunction 9.8
5 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.8
6 muscle hypertrophy 9.8
7 sleep apnea 9.8
8 renal hypertension 9.8
9 cerebral atherosclerosis 9.8
10 porphyria 9.8
11 depression 9.8
12 syncope 9.8
13 posterior urethral valves 9.6 ACE2 AGTR1
14 pre-eclampsia 9.6 AGTR1 ENPEP

Graphical network of the top 20 diseases related to Neurogenic Hypertension:



Diseases related to Neurogenic Hypertension

Symptoms & Phenotypes for Neurogenic Hypertension

Drugs & Therapeutics for Neurogenic Hypertension

Drugs for Neurogenic Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Minocycline Approved, Investigational Phase 1, Phase 2 10118-90-8 5281021
2 Anti-Infective Agents Phase 1, Phase 2
3 Anti-Bacterial Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Recruiting NCT02133885 Phase 1, Phase 2 Minocycline Group
2 Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Recruiting NCT02133872 Phase 1 Minocycline 100mg Group;Minocycline 200mg Group

Search NIH Clinical Center for Neurogenic Hypertension

Genetic Tests for Neurogenic Hypertension

Anatomical Context for Neurogenic Hypertension

MalaCards organs/tissues related to Neurogenic Hypertension:

42
Brain, Medulla Oblongata, Kidney, Hypothalamus, Bone, Spinal Cord, Neutrophil

Publications for Neurogenic Hypertension

Articles related to Neurogenic Hypertension:

(show top 50) (show all 153)
# Title Authors Year
1
Does increased 24-h ambulatory heart rate identify de facto neurogenic hypertension, and facilitate selection of hypertensive patients for renal denervation? ( 30753399 )
2019
2
Contribution of Oxidative Stress and Inflammation to the Neurogenic Hypertension Induced by Intermittent Hypoxia. ( 30050461 )
2018
3
Exaggerated Sympathetic Neurovascular Transduction as a Mechanism of Neurogenic Hypertension: It Is Not All About Activity. ( 29203626 )
2018
4
Neurogenic hypertension: pathophysiology, diagnosis and management. ( 29974290 )
2018
5
Neurogenic hypertension: introduction to the series. ( 30019293 )
2018
6
Intracerebroventricular administration of bone marrow-derived cells attenuates angiotensin II-initiated neurogenic hypertension in rats. ( 30120396 )
2018
7
Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension. ( 30151830 )
2018
8
Kinin B1 Receptor Promotes Neurogenic Hypertension Through Activation of Centrally Mediated Mechanisms. ( 29038201 )
2017
9
Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia. ( 27895191 )
2017
10
Neurogenic hypertension and the secrets of respiration. ( 28438764 )
2017
11
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension. ( 28512108 )
2017
12
Transcriptional networks in rodent models support a role for gut-brain communication in neurogenic hypertension: a review of the evidence. ( 28550087 )
2017
13
Mitochondria and Reactive Oxygen Species Contribute to Neurogenic Hypertension. ( 28615314 )
2017
14
Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats. ( 28720883 )
2017
15
Recent Advances in Neurogenic Hypertension: Dietary Salt, Obesity, and Inflammation. ( 28739972 )
2017
16
Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance. ( 28754499 )
2017
17
Contribution of Orexin to the Neurogenic Hypertension in BPH/2J Mice. ( 26975709 )
2016
18
Furosemide modifies heart hypertrophy and glycosaminoglycan myocardium content in a rat model of neurogenic hypertension. ( 27221775 )
2016
19
Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. ( 27754863 )
2016
20
Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. ( 25489058 )
2015
21
Carotid body overactivity induces respiratory neurone channelopathy contributing to neurogenic hypertension. ( 25900825 )
2015
22
α-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. ( 26254330 )
2015
23
In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. ( 26834545 )
2015
24
Stabilization of hypoxia inducible factor-1α ameliorates acute renal neurogenic hypertension. ( 24309492 )
2014
25
Different impacts of α- and β-blockers in neurogenic hypertension produced by brainstem lesions in rat. ( 24614323 )
2014
26
Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. ( 24688126 )
2014
27
Presympathetic neuron dysfunction--time to reconsider increased intrinsic activity as the cause of neurogenic hypertension. ( 24987020 )
2014
28
Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice. ( 24275840 )
2014
29
Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. ( 24014829 )
2013
30
The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. ( 24002774 )
2013
31
Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. ( 23747290 )
2013
32
Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla and neurogenic hypertension in spontaneously hypertensive rats. ( 22746319 )
2013
33
Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. ( 22958438 )
2012
34
Chiari I malformation with neurogenic hypertension: case report. ( 22890471 )
2012
35
Neurogenic hypertension: revelations from genome-wide gene expression profiling. ( 22639016 )
2012
36
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? ( 22562144 )
2012
37
Coupling between respiratory and sympathetic activities as a novel mechanism underpinning neurogenic hypertension. ( 21445721 )
2011
38
Global identification of the genes and pathways differentially expressed in hypothalamus in early and established neurogenic hypertension. ( 21487032 )
2011
39
Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension. ( 21536990 )
2011
40
Contributions of vascular inflammation in the brainstem for neurogenic hypertension. ( 21601658 )
2011
41
Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension. ( 21755262 )
2011
42
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension. ( 19923158 )
2010
43
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. ( 19926873 )
2010
44
Neurogenic hypertension. ( 20407134 )
2010
45
Brain microglial cytokines in neurogenic hypertension. ( 20547972 )
2010
46
Inflammation and neurogenic hypertension: a new role for the circumventricular organs? ( 20651292 )
2010
47
Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The kidney is not always the target in neurogenic hypertension. ( 21188820 )
2010
48
Is neurogenic hypertension related to vascular inflammation of the brainstem? ( 18585782 )
2009
49
Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. ( 19047792 )
2009
50
Mitochondrial dysfunction and mitochondrial-produced reactive oxygen species: new targets for neurogenic hypertension? ( 19114641 )
2009

Variations for Neurogenic Hypertension

Expression for Neurogenic Hypertension

Search GEO for disease gene expression data for Neurogenic Hypertension.

Pathways for Neurogenic Hypertension

Pathways related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 ACE2 ENPEP

GO Terms for Neurogenic Hypertension

Biological processes related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.4 ACE2 AGTR1
2 regulation of inflammatory response GO:0050727 9.37 ACE2 AGTR1
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.32 ACE2 AGTR1
4 regulation of vasoconstriction GO:0019229 9.26 ACE2 AGTR1
5 regulation of blood vessel diameter GO:0097746 9.16 ACE2 AGTR1
6 angiotensin maturation GO:0002003 8.96 ACE2 ENPEP
7 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.8 ACE2 AGTR1 ENPEP

Molecular functions related to Neurogenic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 8.62 ACE2 ENPEP

Sources for Neurogenic Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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