MCID: NRL004
MIFTS: 44

Neuroleptic Malignant Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Neuroleptic Malignant Syndrome

MalaCards integrated aliases for Neuroleptic Malignant Syndrome:

Name: Neuroleptic Malignant Syndrome 12 76 53 54 59 37 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
neuroleptic malignant syndrome
Prevalence: 1-5/10000 (Europe);

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:14464
ICD10 33 G21.0
ICD9CM 35 333.92
MeSH 44 D009459
NCIt 50 C94829
Orphanet 59 ORPHA94093
MESH via Orphanet 45 D009459
UMLS via Orphanet 74 C0027849
ICD10 via Orphanet 34 G21.0
KEGG 37 H01528
UMLS 73 C0027849

Summaries for Neuroleptic Malignant Syndrome

NIH Rare Diseases : 53 Neuroleptic malignant syndrome is a rare neurological condition that is caused by an adverse reaction to neuroleptic (tranquilizer) or antipsychotic drugs. These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Affected people may experience high fever, muscle stiffness, sweating, unstable blood pressure, altered mental status, and autonomic dysfunction. In most cases, the condition develops within the first 2 weeks of treatment with the drug; however, it may develop any time during the therapy period. The exact underlying cause of neuroleptic malignant syndrome is unknown. In some cases, more than one family member can be affected which suggests there may be a genetic component. Upon diagnosis of the condition, the neuroleptic or antipsychotic drug is generally discontinued under a physician's supervision. Medications and/or other interventions may also be recommended to manage symptoms.

MalaCards based summary : Neuroleptic Malignant Syndrome is related to serotonin syndrome and malignant hyperthermia. An important gene associated with Neuroleptic Malignant Syndrome is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha). The drugs Artemether and Lumefantrine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

NINDS : 54 Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Symptoms include high fever, sweating, unstable blood pressure, stupor, muscular rigidity, and autonomic dysfunction. In most cases, the disorder develops within the first 2 weeks of treatment with the drug; however, the disorder may develop any time during the therapy period. The syndrome can also occur in people taking anti-Parkinsonism drugs known as dopaminergics if those drugs are discontinued abruptly.

Disease Ontology : 12 A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers.

Wikipedia : 76 Neuroleptic malignant syndrome (NMS) is a life-threatening reaction that occasionally occurs in response... more...

Related Diseases for Neuroleptic Malignant Syndrome

Diseases related to Neuroleptic Malignant Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 serotonin syndrome 30.6 CYP2D6 HTR1A
2 malignant hyperthermia 30.2 MB PIK3C2A RYR1
3 myoglobinuria 30.0 MB PIK3C2A
4 disseminated intravascular coagulation 29.8 MB PIK3C2A
5 generalized anxiety disorder 29.3 DRD2 HTR1A
6 acute myocardial infarction 28.9 CHKB MB PIK3C2A
7 parkinson disease, late-onset 28.5 CYP2D6 DRD2 HTR1A
8 virus associated hemophagocytic syndrome 10.5 MB PIK3C2A
9 interstitial myocarditis 10.5 MB PIK3C2A
10 posterior myocardial infarction 10.5 MB PIK3C2A
11 myositis fibrosa 10.5 MB PIK3C2A
12 gas gangrene 10.5 MB PIK3C2A
13 anuria 10.5 MB PIK3C2A
14 galactorrhea 10.5 CYP2D6 DRD2
15 plexopathy 10.4 MB PIK3C2A
16 intermediate coronary syndrome 10.4 MB PIK3C2A
17 tardive dyskinesia 10.4 CYP2D6 DRD2
18 acute mountain sickness 10.4 MB PIK3C2A
19 pseudohyperkalemia, familial, 2, due to red cell leak 10.4 MB PIK3C2A
20 muscle disorders 10.4 PIK3C2A RYR1
21 gastroparesis 10.3 CYP2D6 DRD2
22 acute kidney failure 10.3 MB PIK3C2A
23 encephalitis 10.2
24 social phobia 10.1 DRD2 HTR1A
25 periodic limb movement disorder 10.1 DRD2 HTR1A
26 dementia 10.1
27 cerebritis 10.1
28 drug-induced mental disorder 10.1 DRD2 HTR1A
29 drug psychosis 10.1 DRD2 HTR1A
30 alexithymia 10.1 DRD2 HTR1A
31 schizophrenia 10.1
32 encephalopathy 10.1
33 brain injury 10.0
34 mental depression 10.0 CYP2D6 HTR1A
35 migraine without aura 10.0 DRD2 HTR1A
36 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.0 MB PIK3C2A RYR1
37 bipolar disorder 9.9
38 burns 9.9
39 cerebral palsy 9.9
40 traumatic brain injury 9.9
41 status epilepticus 9.9
42 dystonia 9.9
43 cerebellar degeneration 9.9
44 muscle tissue disease 9.9 MB PIK3C2A RYR1
45 systemic lupus erythematosus 9.9
46 myocardial infarction 9.9
47 diabetes mellitus, ketosis-prone 9.9
48 rigidity and multifocal seizure syndrome, lethal neonatal 9.9
49 infantile liver failure syndrome 1 9.9
50 alacrima, achalasia, and mental retardation syndrome 9.9

Graphical network of the top 20 diseases related to Neuroleptic Malignant Syndrome:



Diseases related to Neuroleptic Malignant Syndrome

Symptoms & Phenotypes for Neuroleptic Malignant Syndrome

MGI Mouse Phenotypes related to Neuroleptic Malignant Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CHKB DRD2 HTR1A NHLRC1 PIK3C2A RYR1
2 homeostasis/metabolism MP:0005376 9.5 CHKB DRD2 HTR1A MB NHLRC1 PIK3C2A
3 muscle MP:0005369 9.02 CHKB DRD2 MB NHLRC1 RYR1

Drugs & Therapeutics for Neuroleptic Malignant Syndrome

Drugs for Neuroleptic Malignant Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Artemether Approved Phase 4 71963-77-4 119380 68911
2
Lumefantrine Approved Phase 4 82186-77-4 6437380
3
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
4
Haloperidol Approved Phase 4,Phase 3,Phase 2 52-86-8 3559
5
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
6 Antipsychotic Agents Phase 4,Phase 3,Phase 2
7 Anti-Infective Agents Phase 4
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Artemether-lumefantrine combination Phase 4
12 Antiemetics Phase 4,Phase 3,Phase 2
13 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
15 decanoic acid Phase 4,Phase 3,Phase 2
16 Dopamine Agents Phase 4,Phase 3,Phase 2
17 Dopamine Antagonists Phase 4,Phase 3,Phase 2
18 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
19 Haloperidol decanoate Phase 4,Phase 3,Phase 2
20 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Psychotropic Drugs Phase 4,Phase 3,Phase 2
23 Tranquilizing Agents Phase 4,Phase 3,Phase 2
24 Central Nervous System Stimulants Phase 4,Not Applicable
25 Dopamine Uptake Inhibitors Phase 4
26 Neurotransmitter Uptake Inhibitors Phase 4
27
Carbidopa Approved Phase 3 28860-95-9 34359 38101
28
Levodopa Approved Phase 3 59-92-7 6047
29
Ziprasidone Approved Phase 3 146939-27-7 60854
30 Quetiapine Fumarate Phase 3 111974-72-2
31 Dopamine agonists Phase 3
32 Adjuvants, Immunologic Phase 3
33 Antiparkinson Agents Phase 3
34 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
35 Carbidopa, levodopa drug combination Phase 3
36 Serotonin Agents Phase 3
37 Serotonin Antagonists Phase 3
38
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
39
Exenatide Approved, Investigational Phase 2 141758-74-9 15991534
40
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
41
Lenvatinib Approved, Investigational Phase 2 417716-92-8
42
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
43
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
44 Hormone Antagonists Phase 2
45 Hormones Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
47 Hypoglycemic Agents Phase 2
48 Incretins Phase 2
49 Anesthetics Phase 2,Not Applicable
50 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Impact of Enhanced Health Facility Care in Uganda Completed NCT01024426 Phase 4
2 Agents Intervening Against Delirium in Intensive Care Unit Recruiting NCT03392376 Phase 4 Haloperidol Injection
3 Peripheral Transcutaneous Neuromodulation of the Post-tibial Nerve for Solifenacin 10 mg. Hyperactive Bladder Syndrome Not yet recruiting NCT03468465 Phase 4 Solifenacin Succinate
4 The Effect of Methylphenidate on Non-motor Symptoms and Postural Control in Parkinson's Disease. Terminated NCT01244269 Phase 4 Methylphenidate;Methylphenidate;Placebo 10;Placebo 20
5 Trial Comparing Haloperidol, Quetiapine and Placebo in the Pharmacological Treatment of Delirium Completed NCT01811459 Phase 3 Quetiapine;Haloperidol;Placebo
6 A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD) Recruiting NCT02549092 Phase 3 ABT-SLV187
7 The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study Recruiting NCT01211522 Phase 3 Haloperidol;Ziprasidone;Placebo
8 Exendin-4 as a Treatment for Parkinson's Disease - Pilot Study Unknown status NCT01174810 Phase 2 Exenatide
9 Mindfulness Based Intervention (MBI) on the Quality of Life and Non-Motor Symptoms (NMS) of Persons With PD Completed NCT01607697 Phase 2
10 Transcutaneous Non-invasive Vagus Nerve Stimulation (t-VNS) in the Treatment of Schizophrenia Completed NCT01176721 Phase 2
11 Nucleus Basalis Deep Brain Stimulation for Thinking & Memory Problems in Parkinson's. Completed NCT01701544 Phase 1, Phase 2
12 Discontinuation of Dasatinib in Patients With Chronic Myeloid Leukemia-CP Who Have Maintained Complete Molecular Remission for Two Years; Dasatinib Stop Trial Recruiting NCT01627132 Phase 2 Dasatinib
13 Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact. Recruiting NCT03513432 Phase 2
14 Phase II Study Assessing the Efficacy and Safety of Lenvatinib for Anaplastic Thyroid Cancer Recruiting NCT02726503 Phase 2 Lenvatinib
15 Identification of a Biomarker Predictive of Evolution of Parkinson Disease Recruiting NCT03230526 Phase 2 [18F]DPA-714 PET scan
16 Physiotherapy, Nutritional Supplement and Anabolic Steroids in Rehabilitation of Patients With Hip Fracture. Recruiting NCT03545347 Phase 2 Nandrolone Decanoate;Sodium Chloride 9mg/ml Injection
17 Rapid Agitation Control With Ketamine in the Emergency Department Not yet recruiting NCT03375671 Phase 2 Ketalar;Midazolam injection;Haloperidol
18 A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease Not yet recruiting NCT03582137 Phase 2 Cannabidiol
19 Study of NMS-1286937 in Adult Patients With Advanced/Metastatic Solid Tumors Completed NCT01014429 Phase 1 NMS-1286937
20 Safety of RG2077 in Patients With Multiple Sclerosis Completed NCT00076934 Phase 1 RG2077 (CTLA4-IgG4m)
21 Follow-up Study to Assess One Boost Immunization With AFFITOPE® PD01A With Regard to Safety and Clinical Activity Completed NCT02216188 Phase 1
22 Follow-up Study to Assess a Second Boost Immunization With AFFITOPE® PD01A With Regard to Safety and Clinical Activity (AFF008AA) Completed NCT02618941 Phase 1
23 Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Active, not recruiting NCT02854683 Phase 1 Normal Saline
24 Recovery of Physical Functioning After Hip Fracture Not yet recruiting NCT02780076 Phase 1
25 Study of NMS-1116354 in Solid Tumors Terminated NCT01016327 Phase 1 NMS-1116354
26 Study of NMS-1116354 in Advanced/Metastatic Solid Tumors Terminated NCT01092052 Phase 1 NMS-1116354
27 Occipital Nerve Stimulation in the Treatment of Migraine Terminated NCT01855672 Phase 1
28 The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study Unknown status NCT02388087 Not Applicable
29 Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients Unknown status NCT01022450
30 Understanding and Appraising the New Medicine Service in England Completed NCT01635361 Not Applicable
31 Non-interventional, Retrospective, Multi-center Study to Evaluate Non-motor Symptoms in Advanced Parkinson Disease (PD) Patients Already Treated With Rotigotine Completed NCT01504529
32 Post-Authorization Safety Surveillance Study of Asenapine in Participants With Bipolar Disorder (P08307) Completed NCT01495741
33 Help-seeking for Health Problems in People With Parkinson's Completed NCT03275649
34 A Feasibility Study of the Impact on Blood Pressure Control of Supplementing Community Pharmacist Services With Structured Information on Blood Pressure and Its Treatment Completed NCT01939860 Not Applicable
35 Distribution of Non-Motor Symptoms in Idiopathic Parkinson's Disease and Secondary Parkinsonism Completed NCT03432338
36 Incidence of Postoperative Neuromuscular Blockade in Post-Anesthesia Care Unit at Parkland Hospital: Does Size Matter? Completed NCT03111082
37 Long Time Follow up After HJ Following Iatrogenic Bile Duct Injuries Completed NCT01447030
38 Study of the Effect of Low Level Laser Light Therapy on Reducing the Appearance of Cellulite in the Thighs and Buttocks. Completed NCT01702259 Not Applicable
39 Postoperative Blood Transfusion for Frail Elderly With Hip Fracture Completed NCT01102010 Early Phase 1
40 rTMS Effects on Smoking Cessation and Cognition in Schizophrenia Completed NCT00736710 Not Applicable
41 Functional Performance Following Emergency High-risk Abdominal Surgery Completed NCT02124356
42 Deep TMS for the Treatment of Patients With Parkinson's Disease and Progressive Supranuclear Palsy Completed NCT02734485 Not Applicable
43 Neuromuscular Electrostimulation in Radiocephalic Fistula Recruiting NCT02925845 Not Applicable
44 Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients Recruiting NCT03004573 Not Applicable
45 Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes Recruiting NCT02309983 Not Applicable
46 Studying Non-motor Symptoms in SPG4 Recruiting NCT03204773
47 Intestinal Colonization in Newborn Infants With Enterostomy Recruiting NCT03340259
48 Effects of TENS and IES on the Autonomous Balance of Normotens Volunteers and Hypertensive Patients Recruiting NCT03258489 Not Applicable
49 Alpha-synuclein Level in Saliva to Differentiate Between Idiopathic Parkinson Disease and Iatrogenic Parkinsonian Syndrome Recruiting NCT03156647
50 Determining Clinical Profile of Parkinson's Disease Among Egyptian Population Recruiting NCT02785510

Search NIH Clinical Center for Neuroleptic Malignant Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: neuroleptic malignant syndrome

Genetic Tests for Neuroleptic Malignant Syndrome

Anatomical Context for Neuroleptic Malignant Syndrome

MalaCards organs/tissues related to Neuroleptic Malignant Syndrome:

41
Kidney, Heart, Brain, Liver, Thyroid, Myeloid, Bone

Publications for Neuroleptic Malignant Syndrome

Articles related to Neuroleptic Malignant Syndrome:

(show top 50) (show all 688)
# Title Authors Year
1
Reversible splenial lesion in neuroleptic malignant syndrome. ( 29696960 )
2018
2
Neuroleptic Malignant Syndrome ( 29489248 )
2018
3
Neuroleptic malignant syndrome: a case responding to electroconvulsive therapy plus bupropion. ( 29441189 )
2018
4
Neuroleptic Malignant Syndrome: Diagnosis and Management. ( 29325237 )
2018
5
Neuroleptic malignant syndrome in pregnancy: case report and literature review. ( 29363376 )
2018
6
Olanzapine as a cause of neuroleptic malignant syndrome, bibliographic review following a clinical case. ( 29892970 )
2018
7
Serotonin syndrome versus neuroleptic malignant syndrome: a case report. ( 29616715 )
2018
8
A Mixed Presentation of Serotonin Syndrome vs Neuroleptic Malignant Syndrome in a 12-Year-Old Boy. ( 29698346 )
2018
9
Neuroleptic malignant syndrome as a presenting feature of subacute sclerosing panencephalitis. ( 29243130 )
2018
10
Dantrolene for Treatment of Suspected Neuroleptic Malignant Syndrome. ( 29548378 )
2018
11
Case report of neuroleptic malignant syndrome with prolonged mental changes and severe dyskinesia. ( 29464897 )
2018
12
A Neuroleptic Malignant Syndrome Without Rigidity. ( 29475219 )
2018
13
Neuroleptic malignant syndrome with thyroid disorder: An unusual case report. ( 28953679 )
2017
14
Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. ( 28144147 )
2017
15
Lurasidone-Associated Neuroleptic Malignant Syndrome. ( 28806387 )
2017
16
Early introduction of clozapine after neuroleptic malignant syndrome may prevent malignant catatonia: A case report. ( 27939254 )
2017
17
Drug information update. Atypical antipsychotics and neuroleptic malignant syndrome: nuances and pragmatics of the association. ( 28811916 )
2017
18
Risperidone-Associated Rhabdomyolysis Without Neuroleptic Malignant Syndrome: A Case Report. ( 27861195 )
2017
19
Neuroleptic malignant syndrome in the trauma intensive care unit: Diagnosis and management of a rare disease in a challenging population. ( 28660166 )
2017
20
Confusing Terminology-Neuroleptic Malignant Syndrome vs Malignant Hyperthermia. ( 28558090 )
2017
21
Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription. ( 28491312 )
2017
22
A Case of "Brief" Aripiprazole-induced Neuroleptic Malignant Syndrome with Symptoms that Only Lasted a Few Hours. ( 28943586 )
2017
23
Neuroleptic Malignant Syndrome/Malignant Catatonia in Child Psychiatry: Literature Review and a Case Series. ( 28398818 )
2017
24
A Validation Study of the International Consensus Diagnostic Criteria for Neuroleptic Malignant Syndrome. ( 28027111 )
2017
25
Neuroleptic malignant syndrome associated with only one dose of metoclopramide in an older adult. ( 28849625 )
2017
26
Pharmacist intervention to detect drug adverse events on admission to the emergency department: Two case reports of neuroleptic malignant syndrome. ( 28488314 )
2017
27
A retrospective analysis of cases with neuroleptic malignant syndrome and an evaluation of risk factors for mortality. ( 29464217 )
2017
28
Early detection of an atypical presentation of neuroleptic malignant syndrome: A case report. ( 29955512 )
2017
29
Anti-N-Methyl-D-Aspartate Receptor Encephalitis and Risk of Neuroleptic Malignant Syndrome. ( 27836566 )
2017
30
Neuroleptic Malignant Syndrome After Early Administration of Risperidone Long-Acting Injection. ( 29195036 )
2017
31
Neuroleptic malignant syndrome in a patient with stable dose of olanzapine. ( 29026773 )
2017
32
Olanzapine-Induced Neuroleptic Malignant Syndrome. ( 28533580 )
2017
33
Managing Manic Delirium in Bipolar Disorder With Features of Mania, Catatonia, and Neuroleptic Malignant Syndrome. ( 29272572 )
2017
34
Neuroleptic malignant syndrome: A neuro-psychiatric emergency: Recognition, prevention, and management. ( 29061403 )
2017
35
Neuroleptic malignant syndrome following quetiapine treatment in a patient with dementia with Lewy bodies. ( 29080512 )
2017
36
Olanzapine-induced Neuroleptic Malignant Syndrome. ( 28615778 )
2017
37
Neuroleptic malignant syndrome (NMS) associated with amisulpride and sertraline use: A case report and discussion. ( 29174670 )
2017
38
Clozapine withdrawal catatonia, psychosis and associated neuroleptic malignant syndrome. ( 28846884 )
2017
39
Olanzapine induced neuroleptic malignant syndrome, treated with electroconvulsive therapy (ECT)-A case report. ( 28736031 )
2017
40
Acute Dystonia Versus Neuroleptic Malignant Syndrome Without Fever in an Eight-Year-Old Child. ( 28045840 )
2017
41
Atypical Neuroleptic Malignant Syndrome: Diagnosis and Proposal for an Expanded Treatment Algorithm: A Case Report. ( 28767476 )
2017
42
Confusing Terminology-Neuroleptic Malignant Syndrome vs Malignant Hyperthermia-Reply. ( 28558105 )
2017
43
Bitemporal ultra-brief pulse electroconvulsive therapy for the treatment of neuroleptic malignant syndrome in a first psychotic episode: a case report. ( 28403325 )
2017
44
Progressive Encephalomyelitis with Rigidity and Myoclonus in an Intellectually Disabled Patient Mimicking Neuroleptic Malignant Syndrome. ( 28352055 )
2017
45
Aripiprazole-induced neuroleptic malignant syndrome. ( 28558896 )
2017
46
Atypical neuroleptic malignant syndrome (NMS). ( 28892745 )
2017
47
Oral Asenapine overdose leading to Neuroleptic Malignant Syndrome (NMS). ( 28711682 )
2017
48
Neuroleptic Malignant Syndrome Following Bilateral Cemented Total Hip Replacements. ( 29151017 )
2017
49
Neuroleptic Malignant Syndrome Associated with Refractory Acute Disseminated Encephalomyelitis. ( 27239186 )
2016
50
Rocuronium-sugammadex for electroconvulsive therapy management in neuroleptic malignant syndrome: A case report. ( 27424873 )
2016

Variations for Neuroleptic Malignant Syndrome

Expression for Neuroleptic Malignant Syndrome

Search GEO for disease gene expression data for Neuroleptic Malignant Syndrome.

Pathways for Neuroleptic Malignant Syndrome

GO Terms for Neuroleptic Malignant Syndrome

Biological processes related to Neuroleptic Malignant Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 release of sequestered calcium ion into cytosol GO:0051209 8.96 DRD2 RYR1
2 response to hypoxia GO:0001666 8.8 DRD2 MB RYR1

Molecular functions related to Neuroleptic Malignant Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 8.96 CYP2D6 DRD2
2 oxygen binding GO:0019825 8.62 CYP2D6 MB

Sources for Neuroleptic Malignant Syndrome

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