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MCID: NRM004
MIFTS: 51

Neuroma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neuroma

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MalaCards integrated aliases for Neuroma:

Name: Neuroma 12 54 43 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2001
MeSH 43 D009463
NCIt 49 C3275
SNOMED-CT 67 443892003
UMLS 71 C0027858
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Summaries for Neuroma

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Disease Ontology : 12 A nervous system benign neoplasm that is characterized as a nerve tissue tumor.

MalaCards based summary : Neuroma is related to acoustic neuroma and multiple mucosal neuroma. An important gene associated with Neuroma is ANK3 (Ankyrin 3), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Developmental Biology. The drugs Mepivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 A neuroma (/njʊəˈroʊmə/; plural: neuromata or neuromas) is a growth or tumor of nerve tissue. Neuromas... more...

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Related Diseases for Neuroma

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Diseases related to Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 557)
# Related Disease Score Top Affiliating Genes
1 acoustic neuroma 35.1 TGFB1 NF2 MGMT
2 multiple mucosal neuroma 33.9 RET GDNF ENO2 CALCA
3 multiple endocrine neoplasia, type iib 33.7 RET GDNF CALCA
4 neurofibromatosis, type i 33.1 S100B RET NF2
5 multiple endocrine neoplasia 32.7 RET GDNF CALCA
6 neurilemmoma 32.0 S100B NF2 GFAP ENO2
7 meningioma, radiation-induced 31.6 S100B NF2 GFAP
8 trigeminal neuralgia 31.1 SCN10A NGF CALCA
9 obstructive hydrocephalus 31.1 NF2 GFAP ENO2
10 neuritis 31.1 IL6 GFAP GDNF
11 plexiform neurofibroma 31.1 S100B NF2 ANK3
12 hydrocephalus 31.1 TGFB1 S100B NGF GFAP GDNF FGFR1
13 carpal tunnel syndrome 31.1 TGFB1 IL6 FGF2
14 thyroid gland medullary carcinoma 31.1 RET GDNF CALCA
15 thyroid carcinoma, familial medullary 31.0 RET GDNF CALCA
16 exophthalmos 31.0 TGFB1 ENO2 CD68
17 meningioma, familial 30.9 RET NF2 MGMT GFAP ENO2 CD68
18 myoblastoma 30.8 ENO2 CD68
19 meningitis 30.7 S100B IL6 GDNF CALCA
20 hemangioma 30.7 RET FGF2 ENO2 CD68
21 benign ependymoma 30.6 S100B NF2 MGMT GFAP ENO2
22 head injury 30.5 S100B ENO2
23 pheochromocytoma 30.5 RET NGF IL6 GDNF FGF2 ENO2
24 prurigo nodularis 30.5 SEMA3A NGF
25 encephalomalacia 30.5 S100B IL6 GFAP
26 subependymoma 30.5 GFAP ENO2
27 spinal cord injury 30.4 IL6 GFAP GDNF
28 granular cell tumor 30.4 S100B GFAP ENO2 CD68
29 intestinal obstruction 30.4 RET IL6 GDNF
30 tuberous sclerosis 30.4 S100B NF2 GFAP ENO2
31 migraine with or without aura 1 30.3 SCN10A S100B NGF IL6 CALCA
32 rare tumor 30.2 RET NF2
33 diabetic neuropathy 30.2 NGF GDNF FGF2 CALCA
34 polyneuropathy 30.2 NGF IL6 GDNF CALCA
35 megacolon 30.1 SEMA3F RET GDNF
36 somatoform disorder 30.1 SCN10A NGF IL6 CALCA
37 hemiplegia 30.0 S100B ENO2 CALCA ACTA2
38 fibromyalgia 30.0 NGF IL6 CALCA
39 paraganglioma 29.9 S100B RET GFAP ENO2 CALCA
40 multiple endocrine neoplasia, type iia 29.9 RET GDNF CALCA
41 parathyroid adenoma 29.8 TGFB1 RET FGF2 CALCA
42 constipation 29.7 S100B RET IL6 GDNF CALCA
43 sarcoma 29.6 S100B RET NF2 IL6 FGFR1 FGF2
44 peripheral nervous system disease 29.6 SCN10A NGF IL6 GFAP GDNF FGF2
45 medulloblastoma 29.3 S100B RET NGF MGMT IL6 GFAP
46 neuroma biliary tract 12.2
47 neurofibromatosis, type ii 12.2
48 neurofibromatosis 11.7
49 neurofibromatosis, type iv, of riccardi 11.2
50 klumpke paralysis 11.2

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to Neuroma
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Symptoms & Phenotypes for Neuroma

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MGI Mouse Phenotypes related to Neuroma:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 ANK3 ENO2 FGF2 FGFR1 GDNF GFAP
2 cardiovascular system MP:0005385 10.3 ACTA2 FGF2 FGFR1 GDNF GFAP IL6
3 homeostasis/metabolism MP:0005376 10.29 FGF2 FGFR1 GFAP IL6 MGMT NF2
4 growth/size/body region MP:0005378 10.27 ENO2 FGFR1 GDNF GFAP IL6 NF2
5 cellular MP:0005384 10.25 ENO2 FGF2 FGFR1 GDNF GFAP IL6
6 mortality/aging MP:0010768 10.25 ANK3 FGF2 FGFR1 GDNF GFAP IL6
7 nervous system MP:0003631 10.22 ANK3 ENO2 FGF2 FGFR1 GDNF GFAP
8 immune system MP:0005387 10.2 CD68 FGFR1 GDNF GFAP IL6 NF2
9 integument MP:0010771 10.09 FGFR1 IL6 NF2 NGF S100B SCN10A
10 muscle MP:0005369 10.07 ACTA2 FGF2 FGFR1 GDNF GFAP IL6
11 no phenotypic analysis MP:0003012 9.86 ANK3 CD68 FGFR1 MGMT NGF RET
12 renal/urinary system MP:0005367 9.76 ANK3 FGFR1 GDNF IL6 NF2 RET
13 respiratory system MP:0005388 9.61 ANK3 ENO2 IL6 MGMT NF2 RET
14 vision/eye MP:0005391 9.32 ACTA2 FGF2 FGFR1 GFAP IL6 NF2
Sources

Drugs & Therapeutics for Neuroma

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Drugs for Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
6 Anti-Inflammatory Agents Phase 4
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 glucocorticoids Phase 4
10 Triamcinolone diacetate Phase 4
11 triamcinolone acetonide Phase 4
12 Triamcinolone hexacetonide Phase 4
13 Antiemetics Phase 4
14 Anti-Bacterial Agents Phase 4
15 Gentamicins Phase 4
16 Anti-Infective Agents Phase 4
17
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
18
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
19 Trace Elements Phase 3
20 Micronutrients Phase 3
21 Vitamins Phase 3
22 Nutrients Phase 3
23 Calciferol Phase 3
24 Calcium, Dietary Phase 3
25
Calcium Nutraceutical Phase 3 7440-70-2 271
26
Capsaicin Approved Phase 2 404-86-4 1548943
27
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
28
Morphine Approved, Investigational Phase 2 57-27-2 5288826
29
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
30
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
31
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
32
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
33
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
34
Bevacizumab Approved, Investigational Phase 2 216974-75-3
35
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
36 Sodium Channel Blockers Phase 2
37 Anti-Arrhythmia Agents Phase 2
38 Diuretics, Potassium Sparing Phase 2
39 Endostatins Phase 2 71581480
40 Analgesics, Opioid Phase 2
41 Narcotics Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Fibrinolytic Agents Phase 2
44 Analgesics Phase 2
45 Antipyretics Phase 2
46 Platelet Aggregation Inhibitors Phase 2
47 Cyclooxygenase Inhibitors Phase 2
48 Antirheumatic Agents Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Immunologic Factors Phase 2

Interventional clinical trials:

(show top 50) (show all 116)
# Name Status NCT ID Phase Drugs
1 Comparison Between Blind and Ultrasound Guided Injection in Morton Neuroma Unknown status NCT03046108 Phase 4 blind injection of Mepivacaine;blind injection of Triamcinolone;guided injection of mepivacaine;guided injection of Triamcinolone
2 Comparison of the Two Different Doses of Dexamethasone on Persistent Mastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
3 A Multicenter, Prospective, Randomized, Comparative Study of Hollow Nerve Conduit and Avance Nerve Graft Evaluating Recovery Outcomes of Nerve Repair in the Hand. (CHANGE) Completed NCT00948025 Phase 4
4 Pathophysiology of Post Amputation Pain Completed NCT01632709 Phase 4 Bupivacaine;Placebo
5 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Suspended NCT02415257 Phase 4 Gentamicin
6 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Suspended NCT02379754 Phase 4 Gentamicins
7 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
8 Vitamin D3 in Sensory Recovery After Digital NERVe Suture: a Randomized Controlled Trial. Recruiting NCT04115982 Phase 3 Cholecalciferol;Placebos
9 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
10 An Open-Label, Multiple-Dose Extension Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02678793 Phase 2 CNTX-4975
11 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02283957 Phase 2 CNTX-4975
12 A Randomized, Double-Blind, Placebo-Controlled Trial of ALGRX 4975 in Subjects With Painful Intermetatarsal Neuroma Completed NCT00130962 Phase 2 ALGRX 4975
13 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
14 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
15 Randomized, Placebo-Controlled, Double-Blind Cross-Over Trial of Opioids Versus Mexiletine in the Treatment of Postamputation Pain Completed NCT00383682 Phase 2 morphine and mexiletine
16 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
17 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
18 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
19 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
20 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
21 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
22 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
23 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
24 Open-label, Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT04283669 Phase 2 Crizotinib
25 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
26 ARM: Axillary Reverse Mapping Active, not recruiting NCT00572481 Phase 2
27 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Active, not recruiting NCT01767792 Phase 2 Bevacizumab
28 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
29 Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Not yet recruiting NCT04351373 Phase 2 intravenous fluorescein sodium
30 Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) Not yet recruiting NCT04374305 Phase 2 Brigatinib
31 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
32 A Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial of Botulinum Toxin Type A for Neuroma Pain Withdrawn NCT01374191 Phase 2 onabotulinum toxin type-A;2nd phase - onabotulinum toxin type-A
33 An Open Label, Ascending Dose Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02550756 Phase 1 CTNX-4975
34 A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma Completed NCT02838758 Phase 1 Lidocaine;Saline
35 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
36 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
37 Comparison of Corticosteroid and Ethanol Injection Therapy in the Treatment of Morton's Neuroma Unknown status NCT00284583 Injection of Steroid into Foot;Injection of Alcohol into Foot;Injection of Lidocaine into Foot
38 NF2 Natural History Consortium Unknown status NCT00004483
39 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
40 Randomized, Placebo-Controlled Trial of Bilateral 3rd/4th Common Digital Foot Nerve Injections to Treat Restless Legs Syndrome Unknown status NCT00656110 equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;Normal saline - 1ml
41 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
42 A Randomised Controlled Trial to Compare the Clinical Effectiveness of Lower Extremity Manipulation to That of Steroid Injection in the Treatment of Morton's Neuroma Unknown status NCT02304094 methylprednisolone
43 Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI Unknown status NCT03593577
44 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
45 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Unknown status NCT03520829
46 Consequence of Unilateral Vestibular Loss on Visual Abilities Unknown status NCT03581331
47 A Randomised, Double-blind, Placebo-controlled, Three-way Cross-over Single Center Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) Completed NCT01298310 Early Phase 1 Xylocaine;Xylocaine;Placebo
48 Open Non-randomized Clinical Investigation to Evaluate the Safety and Effectiveness of the Nerve Capping Device to Prevent Neuroma Formation After Traumatic Nerve Section Completed NCT02528266
49 Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap Completed NCT01684839
50 Effectiveness of Insole on Morton's Neuroma Completed NCT03511677

Search NIH Clinical Center for Neuroma

Cochrane evidence based reviews: neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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MalaCards organs/tissues related to Neuroma:

40
Brain, Bone, Testes, Skin, Spinal Cord, Thyroid, Breast
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Publications for Neuroma

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Articles related to Neuroma:

(show top 50) (show all 5263)
# Title Authors PMID Year
1
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. 61 54
19150372 2009
2
Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. 54 61
17109831 2007
3
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. 54 61
15519868 2004
4
Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. 61 54
12507143 2002
5
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. 61 54
11932982 2002
6
Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. 61 54
11950515 2002
7
Calcitonin gene-related peptide modifies the ectopic discharge from damaged nerve fibres in the ferret. 61 54
11207377 2001
8
Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. 54 61
9179160 1997
9
Evidence for CGRP accumulation and activity in experimental neuromas. 61 54
7864183 1995
10
Case-control study on occupational exposure to extremely low-frequency electromagnetic fields and the association with acoustic neuroma. 61
32422481 2020
11
Soft Tissue Contouring at the Time of Osseointegrated Implant Reconstruction for Lower Extremity Amputation. 61
32187066 2020
12
Operative findings and surgical outcomes in patients undergoing Chiari 1 malformation decompression: relationship to the extent of tonsillar ectopia. 61
31873790 2020
13
Agminated Pacinian neuroma - immunohistochemical studies and literature review. 61
32569416 2020
14
Revision of Recurrent Neuromas. 61
32471616 2020
15
Functional and patient reported outcomes following lateral hallucal sesamoidectomy. 61
32078908 2020
16
Anterocentral Portal in Ankle Arthroscopy. 61
32546005 2020
17
Injection Techniques for Common Chronic Pain Conditions of the Foot: A Comprehensive Review. 61
32107725 2020
18
Hearing Preservation Outcomes and Prognostic Factors in Acoustic Neuroma Surgery: Predicting Cutoffs. 61
32118808 2020
19
Morton's neuroma as a surgical example of entrapment syndrome. 61
32178989 2020
20
Nerve decompression according to A.L. Dellon in Morton's neuroma - A retrospective analysis. 61
32171681 2020
21
Open repair of a plantar artery pseudoaneurysm after Morton's neurectomy. 61
32490299 2020
22
Stereotactic radiosurgery and radiotherapy for acoustic neuromas. 61
30982152 2020
23
The effectiveness of shoe modifications and orthotics in the conservative treatment of Civinini-Morton syndrome: state of art. 61
32555077 2020
24
Success of surgical interventions for direct dental implant-related injuries to the mandibular nerve: a review. 61
32409132 2020
25
Targeted Muscle Reinnervation Improves Residual Limb Pain, Phantom Limb Pain, and Limb Function: A Prospective Study of 33 Major Limb Amputees. 61
32452928 2020
26
Orofacial pain secondary to acoustic neuroma-A case report. 61
32384226 2020
27
Epithelial sheath neuroma: A case report and literature review. 61
32383640 2020
28
Improved Injection Technique of Ethanol for Morton's Neuroma. 61
32013586 2020
29
Radiofrequency Ablation for the Treatment of Painful Neuroma. 61
32354501 2020
30
Neuroma formation following fascicular turnover flap nerve repair. 61
32007428 2020
31
Morton's neuroma - Current concepts review. 61
32405199 2020
32
Targeted Muscle Reinnervation: Outcomes in Treating Chronic Pain Secondary to Extremity Amputation and Phantom Limb Syndrome. 61
31689720 2020
33
Pediatric vestibular schwannomas: case series and a systematic review with meta-analysis. 61
32470932 2020
34
Description and classification of postpartum chronic pain: A multicentric prospective study. 61
32461069 2020
35
Covering the proximal nerve stump with chondroitin sulfate proteoglycans prevents traumatic painful neuroma formation by blocking axon regeneration after neurotomy in Sprague Dawley rats. 61
32470939 2020
36
Cooled Radiofrequency Ablation of a Large Sciatic Neuroma at the Infrapiriformis Foramen for Recalcitrant Phantom Limb Pain in a Below-Knee Amputee. 61
32451532 2020
37
Application of a Porcine Small Intestine Submucosa Nerve Cap for Prevention of Neuromas and Associated Pain. 61
31884890 2020
38
With or without? A retrospective analysis of intravenous contrast utility in magnetic resonance neurography. 61
31691835 2020
39
Impact of Underlying Diagnosis on Speech and Quality of Life Outcomes After Cochlear Implantation for Single-Sided Deafness. 61
32176127 2020
40
Retroperitoneal Approach for Ilioinguinal, Iliohypogastric, and Genitofemoral Neurectomies in the Treatment of Refractory Groin Pain After Inguinal Hernia Repair. 61
32000253 2020
41
Association Between Body Mass Index and Complications in Acoustic Neuroma Surgery. 61
32122225 2020
42
Long term phonatory function following acoustic neuroma surgery: a cohort study. 61
32347145 2020
43
Predictive Value of Preoperative and Intraoperative Neurophysiology in Evaluating Long-term Facial Function Outcome in Acoustic Neuroma Surgery. 61
32176144 2020
44
[The role of facial nerve motor evoked potentials in predicting facial nerve function in vestibular schwannoma surgery]. 61
32344497 2020
45
Neuroma. 61
32115053 2020
46
Traumatic Neuroma and Liver Retransplant. 61
32281531 2020
47
Ultrasound based macroarchitecture delineation and injection of complex stump neuroma. 61
32330834 2020
48
Ultrasound Imaging and Guided Hydrodissection in the Management of a Postamputation Deep Peroneal Neuroma. 61
32237040 2020
49
Targeted Muscle Reinnervation for Treatment of Neuropathic Pain. 61
32115054 2020
50
Surgery for Symptomatic Neuroma: Anatomic Distribution and Predictors of Secondary Surgery. 61
32221257 2020
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Variations for Neuroma

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Expression for Neuroma

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Search GEO for disease gene expression data for Neuroma.
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Pathways for Neuroma

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Pathways related to Neuroma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.5 TGFB1 SOS1 SEMA3A SCN10A NGF IL6
2
Developmental Biology 65
Show member pathways
 13.41 TGFB1 SOS1 SEMA3A SCN10A RET GDNF
3
Akt Signaling 63
Show member pathways
 13.34 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.3 TGFB1 SOS1 RET IL6 GDNF FGFR1
5
CREB Pathway 63
Show member pathways
 13.26 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
6
PAK Pathway 63
Show member pathways
 13.23 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
7
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.16 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
8
p70S6K Signaling 63
Show member pathways
 12.95 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
9
Phospholipase-C Pathway 63
Show member pathways
 12.82 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
10
Pathways in cancer 36
12.77 TGFB1 SOS1 RET IL6 FGFR1 FGF2
11
MAPK signaling pathway 36 1
12.7 TGFB1 SOS1 NGF FGFR1 FGF2
12
NF-KappaB Family Pathway 63
Show member pathways
 12.57 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
13
Toll Comparative Pathway 63
Show member pathways
 12.25 SOS1 IL6 FGFR1 FGF2
14
Proteoglycans in cancer 36
12.17 TGFB1 SOS1 FGFR1 FGF2 ANK3
15
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.12 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
16
Neuroscience 4
12.09 SCN10A S100B RET NGF NF2 GFAP
17
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.05 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
18
Spinal Cord Injury 1
11.94 TGFB1 IL6 GFAP GDNF
19
FGFR1 mutant receptor activation 65
Show member pathways
 11.79 SOS1 FGFR1 FGF2
20
Angiogenesis (CST) 4
11.78 TGFB1 FGFR1 FGF2
21
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.77 TGFB1 IL6 FGF2 ACTA2
22
Endochondral Ossification 1
11.62 TGFB1 FGFR1 FGF2
23
Hepatitis C and Hepatocellular Carcinoma 1
11.5 TGFB1 SOS1 IL6
24
Lung fibrosis 1
11.5 TGFB1 IL6 FGF2 CALCA
25
G-protein signaling_RhoA regulation pathway 22
11.49 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
26
Cell adhesion_Plasmin signaling 22
11.48 TGFB1 FGFR1 FGF2
27
Differentiation Pathway 1
11.46 TGFB1 IL6 FGF2
28
Vemurafenib Pathway, Pharmacodynamics 60
11.41 SOS1 FGFR1 FGF2
29
Signaling events regulated by Ret tyrosine kinase 1
11.33 SOS1 RET GDNF
30
Glypican 1 network 1
11.13 TGFB1 FGFR1 FGF2
31
Neural Stem Cells and Lineage-specific Markers 64
11 S100B NGF GFAP GDNF FGFR1 FGF2
32
G-protein signaling_Rap2B regulation pathway 22
10.82 TGFB1 SEMA3A NGF IL6 GFAP FGFR1
33
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.73 TGFB1 IL6
34
RNAi Pathway 63
10.24 SOS1 RET GDNF
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GO Terms for Neuroma

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Cellular components related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 TGFB1 SEMA3F SEMA3A S100B NGF IL6
2 extracellular space GO:0005615 9.7 TGFB1 SEMA3F SEMA3A S100B NGF IL6
3 neuronal cell body GO:0043025 9.63 TGFB1 SOS1 S100B RET ENO2 CALCA
4 cell body GO:0044297 9.5 NF2 GFAP ACTA2
5 axon GO:0030424 9.17 TGFB1 SEMA3A SCN10A RET NGF CALCA

Biological processes related to Neuroma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.97 TGFB1 SOS1 S100B NGF IL6
2 positive regulation of cell migration GO:0030335 9.94 TGFB1 SEMA3F SEMA3A RET
3 positive regulation of cell proliferation GO:0008284 9.91 TGFB1 S100B IL6 GDNF FGFR1 FGF2
4 positive regulation of protein kinase B signaling GO:0051897 9.88 TGFB1 RET FGFR1 FGF2
5 positive regulation of gene expression GO:0010628 9.85 TGFB1 RET NGF IL6 ANK3 ACTA2
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 TGFB1 NGF IL6
7 positive regulation of MAP kinase activity GO:0043406 9.77 TGFB1 FGFR1 FGF2
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.73 TGFB1 FGFR1 FGF2
9 axon guidance GO:0007411 9.72 SOS1 SEMA3F SEMA3A RET GDNF
10 positive regulation of cell differentiation GO:0045597 9.71 NF2 GDNF FGFR1
11 positive regulation of MAPK cascade GO:0043410 9.71 RET IL6 FGFR1 FGF2
12 lens fiber cell differentiation GO:0070306 9.66 TGFB1 NF2
13 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.65 NGF MGMT
14 positive regulation of phospholipase C activity GO:0010863 9.65 FGFR1 FGF2
15 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.64 SEMA3F SEMA3A
16 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.63 TGFB1 IL6
17 organ induction GO:0001759 9.63 GDNF FGFR1
18 salivary gland morphogenesis GO:0007435 9.62 TGFB1 FGFR1
19 sympathetic ganglion development GO:0061549 9.62 SEMA3F SEMA3A
20 facial nerve structural organization GO:0021612 9.61 SEMA3F SEMA3A
21 axon extension involved in axon guidance GO:0048846 9.61 SEMA3F SEMA3A
22 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.59 SEMA3F SEMA3A
23 branchiomotor neuron axon guidance GO:0021785 9.58 SEMA3F SEMA3A
24 trigeminal nerve structural organization GO:0021637 9.55 SEMA3F SEMA3A
25 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.52 FGFR1 FGF2
26 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.51 SEMA3F SEMA3A
27 sympathetic neuron projection guidance GO:0097491 9.49 SEMA3F SEMA3A
28 sympathetic neuron projection extension GO:0097490 9.48 SEMA3F SEMA3A
29 ventral trunk neural crest cell migration GO:0036486 9.46 SEMA3F SEMA3A
30 neural crest cell migration GO:0001755 9.46 SEMA3F SEMA3A RET GDNF
31 nerve development GO:0021675 9.43 SEMA3F SEMA3A NGF
32 MAPK cascade GO:0000165 9.43 TGFB1 SOS1 RET GDNF FGFR1 FGF2
33 ureteric bud development GO:0001657 8.92 TGFB1 RET GDNF FGFR1

Molecular functions related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 TGFB1 NGF IL6 GDNF FGF2
2 receptor-receptor interaction GO:0090722 8.96 FGFR1 FGF2
Sources

Sources for Neuroma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
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57 OMIM via Orphanet
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63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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