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MCID: NRM004
MIFTS: 51

Neuroma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neuroma

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MalaCards integrated aliases for Neuroma:

Name: Neuroma 12 54 43 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2001
MeSH 43 D009463
NCIt 49 C3275
SNOMED-CT 67 25169009
UMLS 71 C0027858
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Summaries for Neuroma

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Disease Ontology : 12 A nervous system benign neoplasm that is characterized as a nerve tissue tumor.

MalaCards based summary : Neuroma is related to acoustic neuroma and multiple mucosal neuroma. An important gene associated with Neuroma is ANK3 (Ankyrin 3), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Developmental Biology. The drugs Mepivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and skin, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 A neuroma (/nj??'ro?m?/; plural: neuromata or neuromas) is a growth or tumor of nerve tissue. Neuromas... more...

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Related Diseases for Neuroma

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Diseases related to Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 543)
# Related Disease Score Top Affiliating Genes
1 acoustic neuroma 35.1 TGFB1 NF2 MGMT
2 multiple mucosal neuroma 33.9 RET GDNF CALCA
3 multiple endocrine neoplasia, type iib 33.6 RET GDNF CALCA
4 multiple endocrine neoplasia 32.7 RET GDNF CALCA
5 neurilemmoma 32.0 S100B NF2 GFAP ENO2
6 meningioma, radiation-induced 31.6 S100B NF2 GFAP
7 obstructive hydrocephalus 31.1 NF2 GFAP ENO2
8 neuritis 31.1 IL6 GFAP GDNF
9 carpal tunnel syndrome 31.1 TGFB1 IL6 FGF2
10 hydrocephalus 31.1 TGFB1 S100B NGF GFAP GDNF FGFR1
11 thyroid carcinoma, familial medullary 30.9 RET GDNF CALCA
12 thyroid gland medullary carcinoma 30.9 RET GDNF ENO2 CALCA
13 exophthalmos 30.9 TGFB1 FGFR1 CD68
14 meningioma, familial 30.9 RET NF2 MGMT GFAP ENO2 CD68
15 myoblastoma 30.7 ENO2 CD68
16 meningitis 30.7 S100B IL6 GDNF CALCA
17 hemangioma 30.7 RET FGF2 ENO2 CD68
18 benign ependymoma 30.6 S100B NF2 MGMT GFAP ENO2
19 keratitis, hereditary 30.6 NGF IL6 FGF2
20 head injury 30.5 S100B ENO2
21 prurigo nodularis 30.5 SEMA3A NGF
22 subependymoma 30.5 GFAP ENO2
23 spinal cord injury 30.5 IL6 GFAP GDNF
24 pheochromocytoma 30.4 RET NGF IL6 GDNF FGF2 ENO2
25 granular cell tumor 30.4 S100B GFAP ENO2 CD68
26 tuberous sclerosis 30.4 S100B NF2 GFAP ENO2
27 encephalomalacia 30.4 S100B IL6 GFAP CD68
28 complex regional pain syndrome 30.4 IL6 GFAP CALCA
29 intestinal obstruction 30.3 RET IL6 GDNF
30 migraine with or without aura 1 30.2 SCN10A NGF IL6 CALCA
31 diabetic neuropathy 30.2 NGF GDNF FGF2 CALCA
32 somatoform disorder 30.1 SCN10A NGF CALCA
33 polyneuropathy 30.1 NGF NF2 IL6 GDNF CALCA
34 megacolon 30.1 SEMA3F RET GDNF
35 giant cell tumor 30.0 S100B CD68 CALCA
36 hemiplegia 30.0 S100B ENO2 CALCA ACTA2
37 rare tumor 29.9 RET NF2
38 paraganglioma 29.9 S100B RET GFAP ENO2 CALCA
39 multiple endocrine neoplasia, type iia 29.8 RET GDNF CALCA
40 peripheral nervous system disease 29.7 SCN10A NGF IL6 GFAP GDNF CALCA
41 parathyroid adenoma 29.7 TGFB1 RET CALCA
42 constipation 29.7 S100B RET GDNF CALCA
43 sarcoma 29.6 S100B RET NF2 IL6 FGFR1 FGF2
44 medulloblastoma 29.2 S100B RET NGF MGMT IL6 GFAP
45 neuroma biliary tract 12.2
46 neurofibromatosis, type ii 12.1
47 neurofibromatosis, type iv, of riccardi 12.1
48 neurofibromatosis, type i 11.7
49 klumpke paralysis 11.2
50 erb-duchenne and dejerine-klumpke palsies 11.2

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to Neuroma
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Symptoms & Phenotypes for Neuroma

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MGI Mouse Phenotypes related to Neuroma:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 ANK3 ENO2 FGF2 FGFR1 GDNF GFAP
2 cardiovascular system MP:0005385 10.3 ACTA2 FGF2 FGFR1 GDNF GFAP IL6
3 homeostasis/metabolism MP:0005376 10.29 FGF2 FGFR1 GFAP IL6 MGMT NF2
4 growth/size/body region MP:0005378 10.27 ENO2 FGFR1 GDNF GFAP IL6 NF2
5 cellular MP:0005384 10.25 ENO2 FGF2 FGFR1 GDNF GFAP IL6
6 mortality/aging MP:0010768 10.25 ANK3 FGF2 FGFR1 GDNF GFAP IL6
7 nervous system MP:0003631 10.22 ANK3 ENO2 FGF2 FGFR1 GDNF GFAP
8 immune system MP:0005387 10.2 CD68 FGFR1 GDNF GFAP IL6 NF2
9 integument MP:0010771 10.09 FGFR1 IL6 NF2 NGF S100B SCN10A
10 muscle MP:0005369 10.07 ACTA2 FGF2 FGFR1 GDNF GFAP IL6
11 no phenotypic analysis MP:0003012 9.86 ANK3 CD68 FGFR1 MGMT NGF RET
12 renal/urinary system MP:0005367 9.76 ANK3 FGFR1 GDNF IL6 NF2 RET
13 respiratory system MP:0005388 9.61 ANK3 ENO2 IL6 MGMT NF2 RET
14 vision/eye MP:0005391 9.32 ACTA2 FGF2 FGFR1 GFAP IL6 NF2
Sources

Drugs & Therapeutics for Neuroma

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Drugs for Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
6 Anti-Inflammatory Agents Phase 4
7 Hormone Antagonists Phase 4
8 triamcinolone acetonide Phase 4
9 Triamcinolone hexacetonide Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Triamcinolone diacetate Phase 4
13 Antiemetics Phase 4
14 Gastrointestinal Agents Phase 4
15 Autonomic Agents Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 HIV Protease Inhibitors Phase 4
18
protease inhibitors Phase 4
19 BB 1101 Phase 4
20 Central Nervous System Depressants Phase 4
21 Anti-Infective Agents Phase 4
22 Anti-Bacterial Agents Phase 4
23 Gentamicins Phase 4
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
25
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
26
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 6221 5280795
27
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
28 Trace Elements Phase 3
29 Vitamins Phase 3
30 Nutrients Phase 3
31 Ergocalciferols Phase 3
32 Vitamin D2 Phase 3
33 Calcium, Dietary Phase 3
34 Micronutrients Phase 3
35 Calciferol Phase 3
36
Capsaicin Approved Phase 2 404-86-4 1548943
37
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
38
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
39
Morphine Approved, Investigational Phase 2 57-27-2 5288826
40
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
41
Histamine Approved, Investigational Phase 2 51-45-6 774
42
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
43
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
44
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
45
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
46
Bevacizumab Approved, Investigational Phase 2 216974-75-3
47
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
48 Antipruritics Phase 2
49 Dermatologic Agents Phase 2
50 Anti-Arrhythmia Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 Comparison Between Blind and Ultrasound Guided Injection in Morton Neuroma Unknown status NCT03046108 Phase 4 blind injection of Mepivacaine;blind injection of Triamcinolone;guided injection of mepivacaine;guided injection of Triamcinolone
2 Comparison of the Two Different Doses of Dexamethasone on Persistent Mastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
3 A Multicenter, Prospective, Randomized, Comparative Study of Hollow Nerve Conduit and Avance Nerve Graft Evaluating Recovery Outcomes of Nerve Repair in the Hand. (CHANGE) Completed NCT00948025 Phase 4
4 Pathophysiology of Post Amputation Pain Completed NCT01632709 Phase 4 Bupivacaine;Placebo
5 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Suspended NCT02415257 Phase 4 Gentamicin
6 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Suspended NCT02379754 Phase 4 Gentamicins
7 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
8 Vitamin D3 in Sensory Recovery After Digital NERVe Suture: a Randomized Controlled Trial. Not yet recruiting NCT04115982 Phase 3 Cholecalciferol;Placebos
9 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
10 An Open-Label, Multiple-Dose Extension Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02678793 Phase 2 CNTX-4975
11 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02283957 Phase 2 CNTX-4975
12 A Randomized, Double-Blind, Placebo-Controlled Trial of ALGRX 4975 in Subjects With Painful Intermetatarsal Neuroma Completed NCT00130962 Phase 2 ALGRX 4975
13 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
14 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
15 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
16 Randomized, Placebo-Controlled, Double-Blind Cross-Over Trial of Opioids Versus Mexiletine in the Treatment of Postamputation Pain Completed NCT00383682 Phase 2 morphine and mexiletine
17 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
18 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
19 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
20 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
21 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
22 Multicenter Randomized Controlled Phase 2 Trial to Evaluate AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection (TRAVERS) Recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
23 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
24 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
25 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
26 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
27 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Active, not recruiting NCT01767792 Phase 2 Bevacizumab
28 ARM: Axillary Reverse Mapping Active, not recruiting NCT00572481 Phase 2
29 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
30 A Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial of Botulinum Toxin Type A for Neuroma Pain Withdrawn NCT01374191 Phase 2 onabotulinum toxin type-A;2nd phase - onabotulinum toxin type-A
31 An Open Label, Ascending Dose Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02550756 Phase 1 CTNX-4975
32 A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma Completed NCT02838758 Phase 1 Lidocaine;Saline
33 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
34 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
35 Comparison of Corticosteroid and Ethanol Injection Therapy in the Treatment of Morton's Neuroma Unknown status NCT00284583 Injection of Steroid into Foot;Injection of Alcohol into Foot;Injection of Lidocaine into Foot
36 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
37 NF2 Natural History Consortium Unknown status NCT00004483
38 Randomized, Placebo-Controlled Trial of Bilateral 3rd/4th Common Digital Foot Nerve Injections to Treat Restless Legs Syndrome Unknown status NCT00656110 equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;Normal saline - 1ml
39 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
40 A Randomised Controlled Trial to Compare the Clinical Effectiveness of Lower Extremity Manipulation to That of Steroid Injection in the Treatment of Morton's Neuroma Unknown status NCT02304094 methylprednisolone
41 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
42 A Randomised, Double-blind, Placebo-controlled, Three-way Cross-over Single Center Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) Completed NCT01298310 Early Phase 1 Xylocaine;Xylocaine;Placebo
43 Open Non-randomized Clinical Investigation to Evaluate the Safety and Effectiveness of the Nerve Capping Device to Prevent Neuroma Formation After Traumatic Nerve Section Completed NCT02528266
44 Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap Completed NCT01684839
45 Effectiveness of Insole on Morton's Neuroma Completed NCT03511677
46 Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above Knee Amputees Completed NCT00686764
47 Targeted Reinnervation as a Means to Treat Neuromas Associated With Major Limb Amputation Completed NCT02205385
48 Targeted Reinnervation for Neuromas as a Means to Improve Prosthesis Control in Major Limb Amputation Completed NCT02316262
49 Differential Analgesic Effects of Subanesthetic Concentrations of Lidocaine on Spontaneous and Evoked Pain in Human Painful Neuroma Completed NCT02300038 Lidocaine (Xylocaine)
50 Infiltration of Neuromas With Local Anesthetics to Eliminate Pain: A Double-blinded Crossover Study Completed NCT02930551 Lidocaine;Isotonic Saline

Search NIH Clinical Center for Neuroma

Cochrane evidence based reviews: neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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MalaCards organs/tissues related to Neuroma:

40
Brain, Bone, Skin, Thyroid, Testes, Spinal Cord, Breast
Sources

Publications for Neuroma

About this section

Articles related to Neuroma:

(show top 50) (show all 5198)
# Title Authors PMID Year
1
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. 54 61
19150372 2009
2
Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. 54 61
17109831 2007
3
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. 54 61
15519868 2004
4
Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. 54 61
12507143 2002
5
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. 54 61
11932982 2002
6
Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. 54 61
11950515 2002
7
Calcitonin gene-related peptide modifies the ectopic discharge from damaged nerve fibres in the ferret. 54 61
11207377 2001
8
Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. 54 61
9179160 1997
9
Evidence for CGRP accumulation and activity in experimental neuromas. 54 61
7864183 1995
10
A Systematic Review of Interventions for Balance Dysfunction in Patients With Vestibular Schwannoma. 61
31834215 2020
11
Associations of Vestibular Tests With Penn Acoustic Neuroma Quality of Life Scores After Resection of Vestibular Schwannoma. 61
31821250 2020
12
Quality of Life in Vestibular Schwannoma Patients: A Longitudinal Study. 61
31644476 2020
13
The changing landscape of vestibular schwannoma diagnosis and management: A cross-sectional study. 61
30953401 2020
14
Improved Injection Technique of Ethanol for Morton's Neuroma. 61
32013586 2020
15
Mechanical diagnosis and therapy and Morton's neuroma: a case-series. 61
31177965 2020
16
Methodology for creating a chronic osseointegrated neural interface for prosthetic control in rabbits. 61
31711884 2020
17
Impact of Underlying Diagnosis on Speech and Quality of Life Outcomes After Cochlear Implantation for Single-Sided Deafness. 61
32032297 2020
18
68Ga-Prostate-Specific Membrane Antigen PET/CT Findings in Extra-axial Metastasis From Prostate Carcinoma. 61
31833925 2020
19
Predictive Value of Preoperative and Intraoperative Neurophysiology in Evaluating Long-term Facial Function Outcome in Acoustic Neuroma Surgery. 61
31917771 2020
20
Analysis of Preoperative Factors Influencing Hypoglossal-facial 'Side'-to-side Neurorrhaphy for Facial Paralysis after Excision of Acoustic Neuroma. 61
32029056 2020
21
Validation and multidimensional analysis of the japanese penn acoustic neuroma quality-of-life scale. 61
31922264 2020
22
Neuroma formation following fascicular turnover flap nerve repair. 61
32007428 2020
23
Surgery for Symptomatic Neuroma: Anatomic Distribution and Predictors of Secondary Surgery. 61
31977988 2020
24
"'Reply: "Surgery for symptomatic neuroma: Anatomic distribution and predictors of secondary surgery"'. 61
31977989 2020
25
Neuromas and postamputation pain. 61
31568042 2020
26
Long-Term Outcomes of Digital Nerve Repair Accompanied by Digital Artery Injury in Flexor Zone 2. 61
31799405 2020
27
Application of a Porcine Small Intestine Submucosa Nerve Cap for Prevention of Neuromas and Associated Pain. 61
31884890 2020
28
Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates. 61
31969488 2020
29
Cystic-solid hemangioblastoma at the cerebellopontine angle: A case report. 61
32011511 2020
30
Retroperitoneal Approach for Ilioinguinal, Iliohypogastric, and Genitofemoral Neurectomies in the Treatment of Refractory Groin Pain After Inguinal Hernia Repair. 61
32000253 2020
31
Defining the Minimal Clinically Important Difference for Patients With Vestibular Schwannoma: Are all Quality-of-Life Scores Significant? 61
30395303 2019
32
Reply: "Surgery for symptomatic neuroma: Anatomic distribution and predictors of secondary surgery". 61
31880595 2019
33
Comments on "Surgery for symptomatic neuroma: Anatomic distribution and predictors of secondary surgery". 61
31876856 2019
34
Effectiveness of customized insoles in patients with Morton's neuroma: a randomized, controlled, double-blind clinical trial. 61
31505943 2019
35
Dorsal suspension for Morton's neuroma: A comparison with neurectomy. 61
30342917 2019
36
Endoscopic images of amputation neuroma at the cystic duct stump. 61
31302090 2019
37
Arterialized Posterior Interosseous Nerve Graft for Digital Neuroma. 61
31157733 2019
38
"Patient Reported Outcomes Following Surgical Treatment of Symptomatic Digital Neuromas". 61
31876860 2019
39
Pathologic remodeling in human neuromas: insights from clinical specimens. 61
31612277 2019
40
A Surgical Approach to Treat Painful Neuromas of the Supraorbital and Supratrochlear Nerves with Implantation of the Proximal Stump into the Orbit. 61
31719956 2019
41
A Case Study of Combined Perception-Based and Perception-Free Spinal Cord Stimulator Therapy for the Management of Persistent Pain after a Total Knee Arthroplasty. 61
31432457 2019
42
Outcomes, Challenges, and Pitfalls after Targeted Muscle Reinnervation in High-Level Amputees: Is It Worth the Effort? 61
31764652 2019
43
Effect of duration from lingual nerve injury to undergoing microneurosurgery on improving sensory and taste functions: retrospective study. 61
31921714 2019
44
Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain. 61
31876957 2019
45
[Flawed initial treatment of dog bite injury]. 61
31858166 2019
46
Cryoneurolysis for cervicogenic headache - a double blinded randomized controlled study. 61
31675351 2019
47
[Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient in the Differential Diagnosis of Posterior Fossa Solid Hemangioblastoma]. 61
31907124 2019
48
Operative findings and surgical outcomes in patients undergoing Chiari 1 malformation decompression: relationship to the extent of tonsillar ectopia. 61
31873790 2019
49
Non-surgical treatments for Morton's neuroma: A systematic review. 61
31718949 2019
50
Neuroma of the Infrapatellar branch of the saphenous nerve following Total knee Arthroplasty: a case report. 61
31722713 2019
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Variations for Neuroma

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Expression for Neuroma

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Search GEO for disease gene expression data for Neuroma.
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Pathways for Neuroma

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Pathways related to Neuroma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.5 TGFB1 SOS1 SEMA3A SCN10A NGF IL6
2
Developmental Biology 65
Show member pathways
 13.4 TGFB1 SOS1 SEMA3A SCN10A RET GDNF
3
Akt Signaling 63
Show member pathways
 13.34 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.3 TGFB1 SOS1 RET IL6 GDNF FGFR1
5
CREB Pathway 63
Show member pathways
 13.26 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
6
PAK Pathway 63
Show member pathways
 13.23 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
7
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.15 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
8
p70S6K Signaling 63
Show member pathways
 12.94 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
9
Phospholipase-C Pathway 63
Show member pathways
 12.82 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
10
Pathways in cancer 36
12.76 TGFB1 SOS1 RET IL6 FGFR1 FGF2
11
MAPK signaling pathway 36 1
12.7 TGFB1 SOS1 NGF FGFR1 FGF2
12
NF-KappaB Family Pathway 63
Show member pathways
 12.57 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
13
Toll Comparative Pathway 63
Show member pathways
 12.25 SOS1 IL6 FGFR1 FGF2
14
Proteoglycans in cancer 36
12.16 TGFB1 SOS1 FGFR1 FGF2 ANK3
15
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.12 TGFB1 SEMA3A NGF IL6 FGFR1 FGF2
16
Neuroscience 4
12.09 SCN10A S100B RET NGF NF2 GFAP
17
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.05 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
18
Spinal Cord Injury 1
11.93 TGFB1 IL6 GFAP GDNF
19
FGFR1 mutant receptor activation 65
Show member pathways
 11.79 SOS1 FGFR1 FGF2
20
Angiogenesis (CST) 4
11.78 TGFB1 FGFR1 FGF2
21
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.66 TGFB1 IL6 CD68
22
Endochondral Ossification 1
11.61 TGFB1 FGFR1 FGF2
23
Lung fibrosis 1
11.5 TGFB1 IL6 FGF2 CALCA
24
Hepatitis C and Hepatocellular Carcinoma 1
11.49 TGFB1 SOS1 IL6
25
G-protein signaling_RhoA regulation pathway 22
11.49 TGFB1 SOS1 SEMA3A NGF IL6 FGFR1
26
Cell adhesion_Plasmin signaling 22
11.47 TGFB1 FGFR1 FGF2
27
Differentiation Pathway 1
11.46 TGFB1 IL6 FGF2
28
Vemurafenib Pathway, Pharmacodynamics 60
11.39 SOS1 FGFR1 FGF2
29
Signaling events regulated by Ret tyrosine kinase 1
11.32 SOS1 RET GDNF
30
Glypican 1 network 1
11.12 TGFB1 FGFR1 FGF2
31
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11 S100B NGF GFAP GDNF FGFR1 FGF2
32
G-protein signaling_Rap2B regulation pathway 22
10.82 TGFB1 SEMA3A NGF IL6 GFAP FGFR1
33
RNAi Pathway 63
10.23 SOS1 RET GDNF
Sources

GO Terms for Neuroma

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Cellular components related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TGFB1 SEMA3F SEMA3A S100B NGF IL6
2 axon GO:0030424 9.65 TGFB1 SEMA3A RET NGF ANK3
3 cell body GO:0044297 9.5 NF2 GFAP ACTA2
4 neuronal cell body GO:0043025 9.43 TGFB1 SOS1 S100B RET ENO2 CALCA
5 extracellular space GO:0005615 9.36 TGFB1 SEMA3F SEMA3A S100B NGF IL6

Biological processes related to Neuroma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.96 TGFB1 SOS1 S100B NGF IL6
2 positive regulation of cell migration GO:0030335 9.93 TGFB1 SEMA3F SEMA3A RET
3 positive regulation of cell proliferation GO:0008284 9.88 TGFB1 S100B IL6 GDNF FGFR1 FGF2
4 positive regulation of protein kinase B signaling GO:0051897 9.87 TGFB1 RET FGFR1 FGF2
5 positive regulation of gene expression GO:0010628 9.85 TGFB1 RET NGF IL6 ANK3 ACTA2
6 positive regulation of MAP kinase activity GO:0043406 9.77 TGFB1 FGFR1 FGF2
7 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 TGFB1 FGFR1 FGF2
8 axon guidance GO:0007411 9.72 SOS1 SEMA3F SEMA3A RET GDNF
9 positive regulation of cell differentiation GO:0045597 9.71 NF2 GDNF FGFR1
10 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.65 NGF MGMT
11 positive regulation of phospholipase C activity GO:0010863 9.65 FGFR1 FGF2
12 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.64 SEMA3F SEMA3A
13 lens fiber cell differentiation GO:0070306 9.64 TGFB1 NF2
14 enteric nervous system development GO:0048484 9.63 RET GDNF
15 organ induction GO:0001759 9.62 GDNF FGFR1
16 salivary gland morphogenesis GO:0007435 9.62 TGFB1 FGFR1
17 sympathetic ganglion development GO:0061549 9.61 SEMA3F SEMA3A
18 facial nerve structural organization GO:0021612 9.61 SEMA3F SEMA3A
19 axon extension involved in axon guidance GO:0048846 9.6 SEMA3F SEMA3A
20 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.58 SEMA3F SEMA3A
21 branchiomotor neuron axon guidance GO:0021785 9.58 SEMA3F SEMA3A
22 trigeminal nerve structural organization GO:0021637 9.52 SEMA3F SEMA3A
23 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.51 FGFR1 FGF2
24 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.49 SEMA3F SEMA3A
25 sympathetic neuron projection guidance GO:0097491 9.48 SEMA3F SEMA3A
26 sympathetic neuron projection extension GO:0097490 9.46 SEMA3F SEMA3A
27 neural crest cell migration GO:0001755 9.46 SEMA3F SEMA3A RET GDNF
28 ventral trunk neural crest cell migration GO:0036486 9.43 SEMA3F SEMA3A
29 nerve development GO:0021675 9.43 SEMA3F SEMA3A NGF
30 MAPK cascade GO:0000165 9.43 TGFB1 SOS1 RET GDNF FGFR1 FGF2
31 ureteric bud development GO:0001657 8.92 TGFB1 RET GDNF FGFR1

Molecular functions related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 TGFB1 NGF IL6 GDNF FGF2
2 receptor-receptor interaction GO:0090722 8.96 FGFR1 FGF2
Sources

Sources for Neuroma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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