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MCID: NRM004
MIFTS: 50

Neuroma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neuroma

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MalaCards integrated aliases for Neuroma:

Name: Neuroma 12 55 44 15 17 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2001
MeSH 44 D009463
NCIt 50 C3275
SNOMED-CT 68 25169009
UMLS 72 C0027858
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Summaries for Neuroma

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Disease Ontology : 12 A nervous system benign neoplasm that is characterized as a nerve tissue tumor.

MalaCards based summary : Neuroma is related to acoustic neuroma and multiple mucosal neuroma. An important gene associated with Neuroma is ANK3 (Ankyrin 3), and among its related pathways/superpathways are Developmental Biology and Phospholipase-C Pathway. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 75 A neuroma (/njESETE^roESmET/; plural: neuromata or neuromas) is a growth or tumor of nerve tissue.... more...

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Related Diseases for Neuroma

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Diseases related to Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 493)
# Related Disease Score Top Affiliating Genes
1 acoustic neuroma 35.0 TGFB1 NF2 BICRA
2 multiple mucosal neuroma 34.2 RET ENO2
3 multiple endocrine neoplasia, type iib 32.7 RET GDNF CALCA
4 neurilemmoma 31.8 S100B NF2 GFAP ENO2
5 multiple endocrine neoplasia 31.8 RET GDNF CALCA
6 meningioma, radiation-induced 31.5 S100B NF2 GFAP
7 hydrocephalus 31.2 TGFB1 NGF GFAP ENO2
8 meningioma, familial 30.9 NF2 GFAP ENO2 CD68
9 benign ependymoma 30.9 NF2 GFAP ENO2
10 ependymoma 30.5 S100B NF2 GFAP ENO2
11 head injury 30.3 S100B ENO2
12 spinal cord injury 30.3 TGFB1 GFAP GDNF
13 hemangioma 30.3 RET FGF2 ENO2
14 prurigo nodularis 30.2 SEMA3A NGF
15 neurilemmoma of the fifth cranial nerve 30.1 NF2 GFAP CD68
16 diabetic neuropathy 30.0 TRPV1 NGF GDNF
17 thyroid carcinoma, familial medullary 29.8 RET GDNF ENO2 CALCA
18 granular cell tumor 29.7 S100B GFAP ENO2 CD68
19 lichen nitidus 29.5 RET CD68
20 pheochromocytoma 29.4 RET NGF GDNF ENO2 CALCA
21 nervous system disease 29.0 TRPV1 S100B NGF GFAP GDNF ENO2
22 multiple endocrine neoplasia, type iia 28.9 RET GDNF CALCA
23 constipation 28.9 RET GDNF CALCA
24 causalgia 28.8 SCN10A NGF GDNF ENO2 CALCA
25 brachial plexus lesion 28.4 SEMA3F SEMA3A NRP1 GDNF CALCA
26 neuroma biliary tract 12.2
27 neurofibromatosis, type ii 12.1
28 neurofibromatosis, type iv, of riccardi 12.1
29 neurofibromatosis, type i 11.7
30 klumpke paralysis 11.2
31 erb-duchenne and dejerine-klumpke palsies 11.2
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.8
33 cerebral convexity meningioma 10.8 NF2 GFAP
34 primitive neuroectodermal tumor of the cervix uteri 10.8 GFAP ENO2
35 meningothelial meningioma 10.8 NF2 ENO2
36 bednar tumor 10.7 S100B ENO2
37 intraventricular meningioma 10.7 NF2 GFAP
38 melanotic medulloblastoma 10.7 GFAP ENO2
39 rhabdoid meningioma 10.7 NF2 GFAP
40 facial paralysis 10.7
41 gemistocytic astrocytoma 10.7 S100B GFAP
42 epithelioid malignant peripheral nerve sheath tumor 10.7 S100B ENO2
43 fibrous meningioma 10.7 S100B NF2
44 syringocystadenoma papilliferum 10.7 S100B GFAP
45 chordoid meningioma 10.7 S100B GFAP
46 cerebellar medulloblastoma 10.7 GFAP ENO2
47 ossifying fibromyxoid tumor 10.7 S100B ENO2
48 clear cell ependymoma 10.6 GFAP ENO2
49 central nervous system primitive neuroectodermal neoplasm 10.6 GFAP ENO2
50 spinal cancer 10.6 NF2 GFAP

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to Neuroma
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Symptoms & Phenotypes for Neuroma

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MGI Mouse Phenotypes related to Neuroma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 ANK3 ENO2 FGF2 GDNF GFAP NF2
2 cardiovascular system MP:0005385 10.22 ACTA2 FGF2 GDNF GFAP NGF NRP1
3 growth/size/body region MP:0005378 10.2 ENO2 GDNF GFAP NF2 NGF NRP1
4 nervous system MP:0003631 10.17 ANK3 ENO2 FGF2 GDNF GFAP NF2
5 immune system MP:0005387 10.13 CD68 GDNF GFAP NF2 NRP1 RET
6 muscle MP:0005369 10.01 ACTA2 FGF2 GDNF GFAP NGF NRP1
7 neoplasm MP:0002006 9.85 FGF2 NF2 NRP1 RET TGFB1 TRPV1
8 no phenotypic analysis MP:0003012 9.8 ANK3 CD68 NGF RET SCN10A SEMA3A
9 renal/urinary system MP:0005367 9.7 ANK3 GDNF NF2 RET SEMA3A TGFB1
10 respiratory system MP:0005388 9.5 ANK3 ENO2 NF2 RET SCN10A SEMA3A
11 vision/eye MP:0005391 9.23 ACTA2 FGF2 GFAP NF2 NGF NRP1
Sources

Drugs & Therapeutics for Neuroma

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Drugs for Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 91)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
6 Antiemetics Phase 4
7 Gastrointestinal Agents Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Autonomic Agents Phase 4
10 HIV Protease Inhibitors Phase 4
11
protease inhibitors Phase 4
12 BB 1101 Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Anesthetics, Local Phase 4
15 Central Nervous System Depressants Phase 4
16 Anesthetics Phase 4
17 Anti-Inflammatory Agents Phase 4
18 triamcinolone acetonide Phase 4
19 Triamcinolone hexacetonide Phase 4
20 glucocorticoids Phase 4
21 Triamcinolone diacetate Phase 4
22 Hormones Phase 4
23 Hormone Antagonists Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 Anti-Infective Agents Phase 4
26 Gentamicins Phase 4
27 Anti-Bacterial Agents Phase 4
28
Capsaicin Approved Phase 2 404-86-4 1548943
29
Lapatinib Approved, Investigational Phase 2 388082-78-8, 231277-92-2 208908 9941095
30
Morphine Approved, Investigational Phase 2 57-27-2 5288826
31
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
32
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
33
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616 46835353
34
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
35
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
36
Bevacizumab Approved, Investigational Phase 2 216974-75-3
37
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
38
Histamine Approved, Investigational Phase 2 51-45-6 774
39
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
40 Sodium Channel Blockers Phase 2
41 Diuretics, Potassium Sparing Phase 2
42 Anti-Arrhythmia Agents Phase 2
43 Endostatins Phase 2 71581480
44 Narcotics Phase 2
45 Analgesics, Opioid Phase 2
46 Cyclooxygenase Inhibitors Phase 2
47 Analgesics, Non-Narcotic Phase 2
48 Fibrinolytic Agents Phase 2
49 Analgesics Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:

(show top 50) (show all 102)
# Name Status NCT ID Phase Drugs
1 Comparison of the Two Different Doses of Dexamethasone on Persistent Mastectomy Pain Unknown status NCT02551133 Phase 4 dexamethasone
2 A Multicenter, Prospective, Randomized, Comparative Study of Hollow Nerve Conduit and Avance Nerve Graft Evaluating Recovery Outcomes of Nerve Repair in the Hand. (CHANGE) Completed NCT00948025 Phase 4
3 Pathophysiology of Post Amputation Pain Completed NCT01632709 Phase 4 Bupivacaine;Placebo
4 Comparison Between Blind and Ultrasound Guided Injection in Morton Neuroma Recruiting NCT03046108 Phase 4 blind injection of Mepivacaine;blind injection of Triamcinolone;guided injection of mepivacaine;guided injection of Triamcinolone
5 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Suspended NCT02415257 Phase 4 Gentamicin
6 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Suspended NCT02379754 Phase 4 Gentamicins
7 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
8 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
9 An Open-Label, Multiple-Dose Extension Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02678793 Phase 2 CNTX-4975
10 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02283957 Phase 2 CNTX-4975
11 A Randomized, Double-Blind, Placebo-Controlled Trial of ALGRX 4975 in Subjects With Painful Intermetatarsal Neuroma Completed NCT00130962 Phase 2 ALGRX 4975
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
14 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
15 Randomized, Placebo-Controlled, Double-Blind Cross-Over Trial of Opioids Versus Mexiletine in the Treatment of Postamputation Pain Completed NCT00383682 Phase 2 morphine and mexiletine
16 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
17 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
18 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
19 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
20 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
21 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
22 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
23 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
24 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
25 ARM: Axillary Reverse Mapping Active, not recruiting NCT00572481 Phase 2
26 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Active, not recruiting NCT01767792 Phase 2 Bevacizumab
27 Multicenter Randomized Controlled Phase 2 Trial to Evaluate AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection (TRAVERS) Not yet recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
28 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
29 A Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial of Botulinum Toxin Type A for Neuroma Pain Withdrawn NCT01374191 Phase 2 onabotulinum toxin type-A;2nd phase - onabotulinum toxin type-A
30 An Open Label, Ascending Dose Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02550756 Phase 1 CTNX-4975
31 A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma Completed NCT02838758 Phase 1 Lidocaine;Saline
32 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
33 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
34 Comparison of Corticosteroid and Ethanol Injection Therapy in the Treatment of Morton's Neuroma Unknown status NCT00284583 Injection of Steroid into Foot;Injection of Alcohol into Foot;Injection of Lidocaine into Foot
35 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
36 NF2 Natural History Consortium Unknown status NCT00004483
37 Randomized, Placebo-Controlled Trial of Bilateral 3rd/4th Common Digital Foot Nerve Injections to Treat Restless Legs Syndrome Unknown status NCT00656110 equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;Normal saline - 1ml
38 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
39 A Randomised Controlled Trial to Compare the Clinical Effectiveness of Lower Extremity Manipulation to That of Steroid Injection in the Treatment of Morton's Neuroma Unknown status NCT02304094 methylprednisolone
40 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
41 A Randomised, Double-blind, Placebo-controlled, Three-way Cross-over Single Center Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) Completed NCT01298310 Early Phase 1 Xylocaine;Xylocaine;Placebo
42 Open Non-randomized Clinical Investigation to Evaluate the Safety and Effectiveness of the Nerve Capping Device to Prevent Neuroma Formation After Traumatic Nerve Section Completed NCT02528266
43 Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap Completed NCT01684839
44 Effectiveness of Insole on Morton's Neuroma Completed NCT03511677
45 Evaluation of Ultrasonic Neuroma Size With Residual Limb Pain in Above Knee Amputees Completed NCT00686764
46 Targeted Reinnervation as a Means to Treat Neuromas Associated With Major Limb Amputation Completed NCT02205385
47 Targeted Reinnervation for Neuromas as a Means to Improve Prosthesis Control in Major Limb Amputation Completed NCT02316262
48 Differential Analgesic Effects of Subanesthetic Concentrations of Lidocaine on Spontaneous and Evoked Pain in Human Painful Neuroma Completed NCT02300038 Lidocaine (Xylocaine)
49 Infiltration of Neuromas With Local Anesthetics to Eliminate Pain: A Double-blinded Crossover Study Completed NCT02930551 Lidocaine;Isotonic Saline
50 Assessment of Visual Sensitivity, Psychiatric Profile and Quality of Life Following Vestibular Schwannoma Surgery in Patients Prehabituated by Chemical Vestibular Ablation Completed NCT03638310

Search NIH Clinical Center for Neuroma

Cochrane evidence based reviews: neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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MalaCards organs/tissues related to Neuroma:

41
Brain, Bone, Testes, Skin, Spinal Cord, Thyroid, Breast
Sources

Publications for Neuroma

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Articles related to Neuroma:

(show top 50) (show all 5140)
# Title Authors PMID Year
1
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. 9 38
19150372 2009
2
Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. 9 38
17109831 2007
3
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. 9 38
15519868 2004
4
Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. 9 38
12507143 2002
5
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. 9 38
11932982 2002
6
Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. 9 38
11950515 2002
7
Calcitonin gene-related peptide modifies the ectopic discharge from damaged nerve fibres in the ferret. 9 38
11207377 2001
8
Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. 9 38
9179160 1997
9
Evidence for CGRP accumulation and activity in experimental neuromas. 9 38
7864183 1995
10
Fatigue in patients with vestibular schwannoma. 38
31321539 2019
11
Hearing and Quality of Life Over Time in Vestibular Schwannoma Patients: Observation Compared to Stereotactic Radiosurgery. 38
31335799 2019
12
Painful Traumatic Neuromas in Subcutaneous Fat: Visibility and Morphologic Features With Ultrasound. 38
30690764 2019
13
Suppression of neuropathic pain by selective silencing of dorsal root ganglion ectopia using nonblocking concentrations of lidocaine. 38
31095098 2019
14
Targeted muscle reinnervation in oncologic amputees: Early experience of a novel institutional protocol. 38
31197851 2019
15
Intra- and Interobserver Reliability of Size Measurement of Morton Neuromas on Sonography. 38
30618089 2019
16
Characteristics and Outcomes of Pediatric Vestibular Schwannomas. 38
31290804 2019
17
Noise exposure as a risk factor for acoustic neuroma: a systematic review and meta-analysis. 38
31012775 2019
18
Effect of Institutional Volume on Acoustic Neuroma Surgical Outcomes: State Inpatient Database 2009-2013. 38
31203081 2019
19
Palisaded Encapsulated (Solitary Circumscribed) Neuroma: A Review of 30 Cases. 38
30834800 2019
20
Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial. 38
30371518 2019
21
Ultrasound-guided radiofrequency ablation for treatment of Morton's neuroma: initial experience. 38
31409448 2019
22
A Case Study of Combined Perception-Based and Perception-Free Spinal Cord Stimulator Therapy for the Management of Persistent Pain after a Total Knee Arthroplasty. 38
31432457 2019
23
Ulcerated bleeding palisaded encapsulated neuroma of the tongue. 38
31427561 2019
24
Risk Recall of Complications Associated with Vestibular Schwannoma Treatment. 38
30885097 2019
25
Is endoscopic inspection necessary to detect residual disease in acoustic neuroma surgery? 38
31028535 2019
26
Are Acoustic Neuroma Association Patients Characteristically Different Than the General Population Patients? The Benefits and Drawbacks of Survey-Based Studies. 38
31295209 2019
27
Differentiating the General Vestibular Schwannoma Patient Population, Tertiary Referral Center Cohorts, and the Acoustic Neuroma Association Survey Respondents: A Response to the Benefits and Drawbacks of Survey-Based Studies. 38
31295210 2019
28
Diagnostic Criteria for Symptomatic Neuroma: Erratum. 38
31192882 2019
29
Endoscopic images of amputation neuroma at the cystic duct stump. 38
31302090 2019
30
Extended Retro/Infralabyrinthine Approach to Cerebellopontine Angle and Internal Auditory Canal, a Radio-Anatomic Study. 38
31135679 2019
31
Collagen Nerve Conduits and Processed Nerve Allografts for the Reconstruction of Digital Nerve Gaps: A Single-Institution Case Series and Review of the Literature. 38
31003028 2019
32
Brief Electrical Stimulation Promotes Nerve Regeneration Following Experimental In-Continuity Nerve Injury. 38
29893910 2019
33
COâ‚‚ Laser for the Treatment of Auricle Schwannoma: A Case Report and Review of the Literature. 38
31287809 2019
34
Outcomes of surgical repair of a single digital nerve in adults. 38
31079523 2019
35
Management of hydrocephalus after resection of posterior fossa lesions in pediatric and adult patients-predictors for development of hydrocephalus. 38
31286305 2019
36
Malignant Hyperthermia During Translabyrinthine Acoustic Neuroma Surgery After Previous Uneventful Surgery. 38
31157728 2019
37
An investigation of life quality of patients after two different acoustic neuroma resections. 38
31050576 2019
38
Functional results after facial reanimation in iatrogenic facial palsy. 38
31206851 2019
39
[Update on diagnostics and microsurgical treatment of vestibular schwannoma]. 38
31076802 2019
40
Mechanical diagnosis and therapy and Morton's neuroma: a case-series. 38
31177965 2019
41
Surgery for Symptomatic Neuroma: Anatomic Distribution and Predictors of Secondary Surgery. 38
30907815 2019
42
Ultra-high-frequency Ultrasound to Assess Nerve Fascicles in Median Nerve Traumatic Neuroma. 38
31417816 2019
43
Morton's Neuroma Excision: What Are We Really Doing? Which Retractor Is Superior? 38
30111167 2019
44
Targeted Muscle Reinnervation for Prosthesis Optimization and Neuroma Management in the Setting of Transradial Amputation. 38
30733097 2019
45
Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review. 38
31156019 2019
46
Can the amniotic membrane be used to treat peripheral nerve defects? A review of literature. 38
31185315 2019
47
Immunostaining in whole-mount lipid-cleared peripheral nerves and dorsal root ganglia after neuropathy in mice. 38
31182787 2019
48
Inner ear and retrocochlear pathology on magnetic resonance imaging for sudden and progressive asymmetrical sensorineural hearing loss. 38
30497101 2019
49
Main Symptom that Led to Medical Evaluation and Diagnosis of Vestibular Schwannoma and Patient-Reported Tumor Size: Cross-sectional Study in 1,304 Patients. 38
31143577 2019
50
Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study. 38
29931661 2019
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Variations for Neuroma

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Expression for Neuroma

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Search GEO for disease gene expression data for Neuroma.
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Pathways for Neuroma

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Pathways related to Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 66
Show member pathways
 13.07 TGFB1 SEMA3A SCN10A RET NRP1 GDNF
2
Phospholipase-C Pathway 64
Show member pathways
 12.74 TGFB1 SEMA3A NRP1 NGF FGF2 ACTA2
3
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.1 TGFB1 SEMA3A NGF FGF2 ACTA2
4
Neuroscience 4
11.81 SCN10A S100B RET NRP1 NGF NF2
5
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.76 TGFB1 SEMA3A NRP1 NGF FGF2
6
G-protein signaling_RhoA regulation pathway 22
11.45 TGFB1 SEMA3A NGF FGF2
7
Lung fibrosis 1
11.3 TGFB1 FGF2 CALCA
8
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.25 S100B NGF GFAP GDNF FGF2
9
G-protein signaling_Rap2B regulation pathway 22
10.73 TGFB1 SEMA3A NGF GFAP FGF2
Sources

GO Terms for Neuroma

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Cellular components related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 TGFB1 SEMA3F SEMA3A S100B NRP1 NGF
2 dendrite GO:0030425 9.72 TRPV1 SEMA3A RET NGF ANK3
3 cell body GO:0044297 9.61 NF2 GFAP ACTA2
4 neuron projection GO:0043005 9.56 TRPV1 NRP1 NF2 ANK3
5 neuronal cell body GO:0043025 9.43 TRPV1 TGFB1 S100B RET NRP1 ENO2
6 axon GO:0030424 9.17 TGFB1 SEMA3A SCN10A RET NRP1 NGF
7 neurofilament GO:0005883 9.1 NRP1
8 extracellular region GO:0005576 10.02 TGFB1 SEMA3F SEMA3A S100B NRP1 NGF

Biological processes related to Neuroma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 axon guidance GO:0007411 9.95 SEMA3F SEMA3A RET NRP1 GDNF
2 positive regulation of cell migration GO:0030335 9.94 TGFB1 SEMA3F SEMA3A RET
3 MAPK cascade GO:0000165 9.94 TGFB1 RET GDNF FGF2
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 TGFB1 NRP1 FGF2
5 response to wounding GO:0009611 9.82 TGFB1 NRP1 GFAP
6 neural crest cell migration GO:0001755 9.81 SEMA3F SEMA3A RET GDNF
7 ureteric bud development GO:0001657 9.79 TGFB1 RET GDNF
8 semaphorin-plexin signaling pathway GO:0071526 9.78 SEMA3F SEMA3A NRP1
9 negative regulation of axon extension involved in axon guidance GO:0048843 9.74 SEMA3F SEMA3A NRP1
10 sympathetic nervous system development GO:0048485 9.71 SEMA3A NRP1 GDNF
11 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.7 SEMA3F SEMA3A NRP1
12 hyaluronan catabolic process GO:0030214 9.68 TGFB1 FGF2
13 negative regulation of cell-cell adhesion GO:0022408 9.67 TGFB1 NF2
14 lens fiber cell differentiation GO:0070306 9.67 TGFB1 NF2
15 sympathetic ganglion development GO:0061549 9.67 SEMA3F SEMA3A NRP1
16 enteric nervous system development GO:0048484 9.66 RET GDNF
17 commissural neuron axon guidance GO:0071679 9.66 NRP1 GDNF
18 facial nerve structural organization GO:0021612 9.65 SEMA3F SEMA3A NRP1
19 axonogenesis involved in innervation GO:0060385 9.63 SEMA3A NRP1
20 axon extension involved in axon guidance GO:0048846 9.63 SEMA3F SEMA3A NRP1
21 trigeminal ganglion development GO:0061551 9.62 SEMA3A NRP1
22 dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 9.62 SEMA3A NRP1
23 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.61 SEMA3F SEMA3A NRP1
24 regulation of axon extension involved in axon guidance GO:0048841 9.6 SEMA3A NRP1
25 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.59 SEMA3A NRP1
26 facioacoustic ganglion development GO:1903375 9.58 SEMA3A NRP1
27 basal dendrite arborization GO:0150020 9.58 SEMA3A NRP1
28 branchiomotor neuron axon guidance GO:0021785 9.58 SEMA3F SEMA3A NRP1
29 response to pain GO:0048265 9.56 TRPV1 RET
30 trigeminal nerve structural organization GO:0021637 9.54 SEMA3F SEMA3A NRP1
31 ventral trunk neural crest cell migration GO:0036486 9.5 SEMA3F SEMA3A NRP1
32 sympathetic neuron projection guidance GO:0097491 9.43 SEMA3F SEMA3A NRP1
33 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.37 TRPV1
34 sympathetic neuron projection extension GO:0097490 9.33 SEMA3F SEMA3A NRP1
35 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.13 SEMA3F SEMA3A NRP1
36 nerve development GO:0021675 8.92 SEMA3F SEMA3A NRP1 NGF
37 positive regulation of transcription, DNA-templated GO:0045893 10.08 TGFB1 RET FGF2 BICRA ACTA2
38 nervous system development GO:0007399 10.05 SEMA3A RET NRP1 GDNF FGF2
39 positive regulation of gene expression GO:0010628 10.03 TGFB1 RET NGF ANK3 ACTA2

Molecular functions related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.92 TGFB1 NGF GDNF FGF2
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3 CDC
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