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MCID: NRM004
MIFTS: 49

Neuroma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Neuroma

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MalaCards integrated aliases for Neuroma:

Name: Neuroma 12 54 44 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2001
MeSH 44 D009463
NCIt 50 C3275
SNOMED-CT 67 25169009
UMLS 71 C0027858
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Summaries for Neuroma

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Disease Ontology : 12 A nervous system benign neoplasm that is characterized as a nerve tissue tumor.

MalaCards based summary : Neuroma is related to acoustic neuroma and multiple endocrine neoplasia, type iib. An important gene associated with Neuroma is ANK3 (Ankyrin 3), and among its related pathways/superpathways are Developmental Biology and Cytokine Signaling in Immune system. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and thyroid, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 74 A neuroma (/njʊəˈroʊmə/; plural: neuromata or neuromas) is a growth or tumor of nerve tissue. Neuromas... more...

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Related Diseases for Neuroma

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Diseases related to Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 528)
# Related Disease Score Top Affiliating Genes
1 acoustic neuroma 33.3 TGFB1 NF2 MGMT
2 multiple endocrine neoplasia, type iib 31.9 RET GDNF CALCA
3 multiple mucosal neuroma 31.9 RET GDNF ENO2 CALCA
4 neurilemmoma 31.6 S100B NF2 MUC1 GFAP ENO2
5 neurofibromatosis, type i 31.4 SOS1 S100B RET NF2 MGMT GFAP
6 neurofibroma 31.2 S100B NF2 MUC1
7 hydrocephalus 30.8 TGFB1 S100B NGF GFAP GDNF ENO2
8 glomus tumor 30.7 S100B MUC1 ENO2
9 trigeminal neuralgia 30.7 SCN10A NGF CALCA
10 meningioma, familial 30.7 S100B RET NF2 MUC1 GFAP CD68
11 obstructive hydrocephalus 30.7 NF2 GFAP ENO2
12 thyroid gland medullary carcinoma 30.7 RET GDNF CALCA
13 plexiform neurofibroma 30.6 S100B NF2 ANK3
14 thyroid carcinoma, familial medullary 30.6 RET GDNF CALCA
15 neuritis 30.5 TGFB1 IL6 GFAP GDNF
16 myoblastoma 30.4 ENO2 CD68
17 otosclerosis 30.4 TGFB1 NF2 IL6 CALCA
18 spindle cell sarcoma 30.4 S100B NF2 MUC1 IL6
19 brachial plexus lesion 30.3 SEMA3F GDNF
20 sarcoma 30.2 S100B NF2 MUC1 IL6 FGF2
21 cellular ependymoma 30.2 S100B NF2 MUC1 MGMT GFAP
22 prurigo nodularis 30.2 SEMA3A NGF
23 head injury 30.2 S100B ENO2
24 subependymoma 30.1 GFAP ENO2
25 acute cholangitis 30.1 MUC1 IL6 CALCA
26 spinal cord injury 30.1 IL6 GFAP GDNF
27 pheochromocytoma 30.1 RET NGF IL6 GDNF FGF2 ENO2
28 encephalomalacia 30.1 S100B IL6 GFAP
29 nerve compression syndrome 30.0 NGF IL6 CALCA
30 granular cell tumor 30.0 S100B GFAP ENO2 CD68
31 rare tumor 30.0 RET NF2
32 tuberous sclerosis 30.0 S100B NF2 GFAP ENO2
33 basal cell carcinoma 30.0 MUC1 IL6 FGF2 ENO2 CD68
34 malignant astrocytoma 29.9 S100B MGMT GFAP FGF2
35 causalgia 29.9 SCN10A NGF CALCA
36 back pain 29.9 IL6 CALCA
37 nervous system disease 29.8 NGF IL6 GFAP GDNF FGF2
38 intestinal obstruction 29.8 RET IL6 GDNF
39 migraine with or without aura 1 29.8 SCN10A S100B NGF IL6 CALCA
40 keratitis, hereditary 29.8 NGF IL6 FGF2
41 paraganglioma 29.8 S100B RET GFAP ENO2 CALCA
42 fibromyalgia 29.7 NGF IL6 CALCA
43 diabetic neuropathy 29.7 NGF GDNF FGF2 CALCA
44 somatoform disorder 29.7 SCN10A NGF IL6 CALCA
45 hemiplegia 29.7 S100B ENO2 CALCA ACTA2
46 multiple endocrine neoplasia, type iia 29.7 RET GDNF CALCA
47 medulloblastoma 29.6 S100B NGF MGMT IL6 GFAP FGF2
48 rhabdomyosarcoma 29.5 SOS1 S100B MGMT GFAP FGF2 ENO2
49 parathyroid adenoma 29.5 TGFB1 RET FGF2 CALCA
50 peripheral nervous system disease 28.9 SCN10A S100B NGF NF2 IL6 GFAP

Graphical network of the top 20 diseases related to Neuroma:



Diseases related to Neuroma
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Symptoms & Phenotypes for Neuroma

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MGI Mouse Phenotypes related to Neuroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ANK3 ENO2 FGF2 GDNF GFAP IL6
2 nervous system MP:0003631 10.13 ANK3 ENO2 FGF2 GDNF GFAP IL6
3 cardiovascular system MP:0005385 10.11 ACTA2 FGF2 GDNF GFAP IL6 NGF
4 muscle MP:0005369 9.97 ACTA2 FGF2 GDNF GFAP IL6 NGF
5 no phenotypic analysis MP:0003012 9.7 ANK3 CD68 MGMT NGF RET SCN10A
6 respiratory system MP:0005388 9.61 ANK3 ENO2 IL6 MGMT NF2 RET
7 vision/eye MP:0005391 9.28 ACTA2 FGF2 GFAP IL6 NF2 NGF
Sources

Drugs & Therapeutics for Neuroma

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Drugs for Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 6221 5280795
6
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
7 Nutrients Phase 3
8 Micronutrients Phase 3
9 Trace Elements Phase 3
10 Vitamins Phase 3
11 Calcium, Dietary Phase 3
12 Calciferol Phase 3
13
Calcium Nutraceutical Phase 3 7440-70-2 271
14
Capsaicin Approved Phase 2 404-86-4 1548943
15
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
16
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
17
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
18
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
19
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
20
Bevacizumab Approved, Investigational Phase 2 216974-75-3
21
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
22 Immunosuppressive Agents Phase 2
23 Immunologic Factors Phase 2
24 Endostatins Phase 2 71581480
25 Immunoglobulins Phase 2
26 Antibodies Phase 2
27 Immunoglobulins, Intravenous Phase 2
28 Antibodies, Monoclonal Phase 2
29 Anti-Inflammatory Agents Phase 2
30 Analgesics, Non-Narcotic Phase 2
31 Platelet Aggregation Inhibitors Phase 2
32 Cyclooxygenase Inhibitors Phase 2
33 Fibrinolytic Agents Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Antirheumatic Agents Phase 2
36 Analgesics Phase 2
37 Antipyretics Phase 2
38 Protein Kinase Inhibitors Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Antineoplastic Agents, Immunological Phase 2
41 Mitogens Phase 2
42 Endothelial Growth Factors Phase 2
43
Lidocaine Approved, Vet_approved Phase 1 137-58-6 3676
44
Nitrous oxide Approved, Vet_approved Phase 1 10024-97-2 948
45
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
46
Triamcinolone Approved, Vet_approved Phase 1 124-94-7 31307
47 Sodium Channel Blockers Phase 1
48 Diuretics, Potassium Sparing Phase 1
49 Anti-Arrhythmia Agents Phase 1
50 Dermatologic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Comparison Between Blind and Ultrasound Guided Injection in Morton Neuroma Unknown status NCT03046108 Phase 4 blind injection of Mepivacaine;blind injection of Triamcinolone;guided injection of mepivacaine;guided injection of Triamcinolone
2 Pathophysiology of Post Amputation Pain Completed NCT01632709 Phase 4 Bupivacaine;Placebo
3 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Withdrawn NCT02415257 Phase 4 Gentamicin
4 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Withdrawn NCT02379754 Phase 4 Gentamicins
5 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
6 Vitamin D3 in Sensory Recovery After Digital NERVe Suture: a Randomized Controlled Trial. Recruiting NCT04115982 Phase 3 Cholecalciferol;Placebos
7 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Unknown status NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
8 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
9 An Open-Label, Multiple-Dose Extension Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02678793 Phase 2 CNTX-4975
10 A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02283957 Phase 2 CNTX-4975
11 A Randomized, Double-Blind, Placebo-Controlled Trial of ALGRX 4975 in Subjects With Painful Intermetatarsal Neuroma Completed NCT00130962 Phase 2 ALGRX 4975
12 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
13 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Completed NCT01125046 Phase 2
14 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
15 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
16 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
17 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
18 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
19 Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) Recruiting NCT04374305 Phase 2 Brigatinib
20 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
21 Open-label, Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT04283669 Phase 2 Crizotinib
22 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
23 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
24 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Active, not recruiting NCT01767792 Phase 2 Bevacizumab
25 Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Not yet recruiting NCT04351373 Phase 2 intravenous fluorescein sodium
26 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
27 A Prospective, Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Trial of Botulinum Toxin Type A for Neuroma Pain Withdrawn NCT01374191 Phase 2 onabotulinum toxin type-A;2nd phase - onabotulinum toxin type-A
28 A 3-arm Randomized Controlled Study Comparing Ultrasound-guided Cryoablation, Ultrasound-guided Perineural Lidocaine and Ultrasound-guided Perineural Saline to Treat Intermetatarsal Neuroma Completed NCT02838758 Phase 1 Lidocaine;Saline
29 An Open Label, Ascending Dose Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma) Completed NCT02550756 Phase 1 CTNX-4975
30 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
31 Triamcinolone Acetonide Levels in Cochlear Perilymph, Lateral Canal and CSF in Patients With Vestibular Schwannomas Recruiting NCT04658836 Phase 1 Triamcinolone Acetonide 40mg/mL
32 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
33 Comparison of Corticosteroid and Ethanol Injection Therapy in the Treatment of Morton's Neuroma Unknown status NCT00284583 Injection of Steroid into Foot;Injection of Alcohol into Foot;Injection of Lidocaine into Foot
34 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma : Feasibility Study Unknown status NCT02948790
35 A Randomised Controlled Trial to Compare the Clinical Effectiveness of Lower Extremity Manipulation to That of Steroid Injection in the Treatment of Morton's Neuroma Unknown status NCT02304094 methylprednisolone
36 Randomized, Placebo-Controlled Trial of Bilateral 3rd/4th Common Digital Foot Nerve Injections to Treat Restless Legs Syndrome Unknown status NCT00656110 equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;Normal saline - 1ml
37 Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI Unknown status NCT03593577
38 Consequence of Unilateral Vestibular Loss on Visual Abilities Unknown status NCT03581331
39 NF2 Natural History Consortium Unknown status NCT00004483
40 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Unknown status NCT03520829
41 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
42 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
43 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
44 Vegetative Monitoring During Brainstem-associated Surgery Unknown status NCT03666507
45 Vertigo Symptoms, Balance and Vestibular Function in Patients With Vestibular Schwannoma Unknown status NCT03346889
46 Specific Block of the Plantar Branches of the Tibial Nerve Under Ultrasound for Foot Surgery : A Monocentric Pilot Study Completed NCT03504462
47 A Randomised, Double-blind, Placebo-controlled, Three-way Cross-over Single Center Study to Characterize the Phenotype in Patients With Morton's Neuroma and to Explore the Effect of Local Administration of Xylocaine (Lidocaine) Completed NCT01298310 Early Phase 1 Xylocaine;Xylocaine;Placebo
48 Effectiveness of Insole on Morton's Neuroma Completed NCT03511677
49 Exploration and Estimation of Intratumoral Concentration and Activity of Lapatinib in Vivo in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
50 Whole Exome Sequencing (WES) of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285

Search NIH Clinical Center for Neuroma

Cochrane evidence based reviews: neuroma

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Genetic Tests for Neuroma

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Anatomical Context for Neuroma

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MalaCards organs/tissues related to Neuroma:

40
Skin, Spinal Cord, Thyroid, Tongue, Appendix, Breast, Endothelial
Sources

Publications for Neuroma

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Articles related to Neuroma:

(show top 50) (show all 5372)
# Title Authors PMID Year
1
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks. 61 54
19150372 2009
2
Vanilloid receptor 1 (TRPV1) expression in lingual nerve neuromas from patients with or without symptoms of burning pain. 54 61
17109831 2007
3
Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. 61 54
15519868 2004
4
Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G. 61 54
12507143 2002
5
Ankyrin G and voltage gated sodium channels colocalize in human neuroma--key proteins of membrane remodeling after axonal injury. 61 54
11950515 2002
6
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma. 61 54
11932982 2002
7
Calcitonin gene-related peptide modifies the ectopic discharge from damaged nerve fibres in the ferret. 61 54
11207377 2001
8
Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. 61 54
9179160 1997
9
Evidence for CGRP accumulation and activity in experimental neuromas. 54 61
7864183 1995
10
Morton's neuroma: review of anatomy, pathomechanism, and imaging. 61
33168237 2021
11
Predicting Functional Outcomes and Length of Stay Following Acoustic Neuroma Resection. 61
32757415 2021
12
Amputation Revision Surgery - Refining the surgical approach. Ten years of experience and 250 cases, impressions, outcomes, and thoughts for the future. 61
33602538 2021
13
Ultrasound features of traumatic digital nerve injuries of the hand with surgical confirmation. 61
33538864 2021
14
Application of Spare Parts in Combination with Targeted Muscle Reinnervation Surgery. 61
33565835 2021
15
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review. 61
33568390 2021
16
Ulnar neuropathy at the elbow. 61
33321238 2021
17
A Comprehensive Review and Update of Post-surgical Cutaneous Nerve Entrapment. 61
33547511 2021
18
A comprehensive analysis of medium-term outcomes of open first dorsal compartment release for de Quervain's syndrome. 61
33099034 2021
19
Prospective Study of Disease-Specific Quality-of-Life in Sporadic Vestibular Schwannoma Comparing Observation, Radiosurgery, and Microsurgery. 61
33177408 2021
20
Superficial peroneal nerve neuroma after syndesmotic stabilisation surgery. 61
33542001 2021
21
Treating Morton's neuroma by injection, neurolysis, or neurectomy: a systematic review and meta-analysis of pain and satisfaction outcomes. 61
32056015 2021
22
Patient-Related Outcome Measures (PROMs) With Nonoperative and Operative Management of Morton's Neuroma. 61
33019802 2021
23
Evolution in Management Trends of Sporadic Vestibular Schwannoma in the United States Over the Last Half-century. 61
33229882 2021
24
Future in regional anesthesia and pain medicine: neuropathic pain and robotic limbs. 61
33432796 2021
25
What Factors Are Associated with Reoperation After Operative Treatment of Terrible Triad Injuries? 61
32667748 2021
26
Nerve Grafting for Chronic PIN Palsy Due to Radiocapitellar Joint Entrapment 2 Years Following Closed Reduction of a Pediatric Monteggia Fracture-Dislocation: A Case Report With 1-Year Follow-up. 61
33491470 2021
27
Management of acute lesser toe pain. 61
33406375 2021
28
Long-Term Outcomes after Surgical Treatment of Radial Sensory Nerve Neuromas: Patient-Reported Outcomes and Rate of Secondary Surgery. 61
33002982 2021
29
[Surgical management of peripheral nerves after extremity loss]. 61
33231741 2021
30
Prevalence of residual limb pain and symptomatic neuromas after lower extremity amputation: a systematic review and meta-analysis. 61
33470746 2021
31
Peripheral Inflammatory Blood Markers in Diagnosis of Glioma and IDH Status. 61
33551616 2021
32
Common Complaints of the Hands and Feet. 61
33246518 2021
33
An ultrasonographic and electromyographic evaluation of jumping stump possibly due to a neuroma in a patient with transradial amputation: A case report. 61
32986653 2021
34
The characteristics of vHIT gain and PR score in peripheral vestibular disorders. 61
32930021 2021
35
Neuropathic Pain: From Mechanisms to Treatment. 61
32584191 2021
36
Bony implantation of neuroma as a possible cause for secondary fractures: a case report. 61
32659133 2021
37
Targeted Muscle Reinnervation: A Paradigm Shift for Neuroma Management and Improved Prosthesis Control in Major Limb Amputees. 61
33405489 2021
38
Impact of Reconstruction With Hydroxyapatite Bone Cement on CSF Leak Rate in Retrosigmoid Approach to Vestibular Schwannoma Resection: A Review of 196 Cases. 61
33481543 2021
39
Ultrasound findings of plantar plate tears of the lesser metatarsophalangeal joints. 61
33423073 2021
40
The surgical management of extra-cranial trigeminal nerve palsies: A retrospective case series. 61
33422495 2020
41
Osseointegration of Extremity Prostheses: A Primer for the Plastic Surgeon. 61
33234978 2020
42
Nerve Ultrasound in Traumatic and Iatrogenic Peripheral Nerve Injury. 61
33375348 2020
43
ESTRO ACROP guideline for target volume delineation of skull base tumors. 61
33309848 2020
44
Efficacy and Comparison of Vestibular Rehabilitation Exercises on Quality of Life in Patients with Vestibular Disorders. 61
33088777 2020
45
Hearing Status and Aural Rehabilitative Profile of 878 Patients With Sporadic Vestibular Schwannoma. 61
33296080 2020
46
Dorsal Coaptation for the Treatment of Digital Neuroma. 61
33375993 2020
47
Prevention of symptomatic neuroma in traumatic digital amputation: A RAND/UCLA appropriateness method consensus study. 61
32178845 2020
48
Solitary circumscribed neuroma of the glans penis. An unusual finding. 61
33423423 2020
49
Relationship Between Sensory Symptoms, Mulder's Sign, and Dynamic Ultrasonographic Findings in Morton's Neuroma. 61
32856473 2020
50
Endobronchial neurogenic tumor consisting of the features of a solitary circumscribed neuroma. 61
33447438 2020
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Variations for Neuroma

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Expression for Neuroma

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Search GEO for disease gene expression data for Neuroma.
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Pathways for Neuroma

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Pathways related to Neuroma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.39 TGFB1 SOS1 SEMA3A SCN10A RET GDNF
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.25 TGFB1 SOS1 RET MUC1 IL6 GDNF
3
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.15 TGFB1 SOS1 SEMA3A NGF IL6 FGF2
4
p70S6K Signaling 63
Show member pathways
 12.94 TGFB1 SOS1 SEMA3A NGF IL6 FGF2
5
Phospholipase-C Pathway 63
Show member pathways
 12.84 TGFB1 SOS1 SEMA3A NGF IL6 FGF2
6
Pathways in cancer 36
12.73 TGFB1 SOS1 RET IL6 FGF2
7
NF-KappaB Family Pathway 63
Show member pathways
 12.59 TGFB1 SEMA3A NGF IL6 FGF2
8
Calcium signaling pathway 36
12.29 RET NGF GDNF FGF2
9
Proteoglycans in cancer 36
12.2 TGFB1 SOS1 FGF2 ANK3
10
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.13 TGFB1 SEMA3A NGF IL6 FGF2
11
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12 TGFB1 SOS1 SEMA3A NGF IL6 FGF2
12
Spinal Cord Injury 1
11.84 TGFB1 IL6 GFAP GDNF
13
Interleukin-4 and 13 signaling 65
11.79 TGFB1 MUC1 IL6 FGF2
14
Neuroscience 4
11.76 SCN10A S100B RET NGF NF2 GFAP
15
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.65 TGFB1 IL6 FGF2 ACTA2
16
Hepatitis C and Hepatocellular Carcinoma 1
11.43 TGFB1 SOS1 IL6
17
Lung fibrosis 1
11.42 TGFB1 IL6 FGF2 CALCA
18
G-protein signaling_RhoA regulation pathway 23
11.42 TGFB1 SOS1 SEMA3A NGF IL6 FGF2
19
Differentiation Pathway 1
11.39 TGFB1 IL6 FGF2
20
Signaling events regulated by Ret tyrosine kinase 1
11.25 SOS1 RET GDNF
21
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.25 S100B NGF GFAP GDNF FGF2
22
G-protein signaling_Rap2B regulation pathway 23
10.86 TGFB1 SEMA3A NGF IL6 GFAP FGF2
23
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.7 TGFB1 IL6
24
RNAi Pathway 63
10.16 SOS1 RET GDNF
Sources

GO Terms for Neuroma

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Cellular components related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TGFB1 SEMA3F SEMA3A S100B NGF MUC1
2 neuronal cell body GO:0043025 9.65 TGFB1 SOS1 RET ENO2 CALCA
3 cell body GO:0044297 9.5 NF2 GFAP ACTA2
4 axon GO:0030424 9.5 TGFB1 SEMA3A SCN10A RET NGF CALCA
5 extracellular space GO:0005615 9.4 TGFB1 SEMA3F SEMA3A S100B NGF MUC1

Biological processes related to Neuroma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.89 TGFB1 SEMA3F SEMA3A RET
2 cytokine-mediated signaling pathway GO:0019221 9.8 TGFB1 SOS1 MUC1 IL6 FGF2
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 TGFB1 NGF IL6
4 odontogenesis of dentin-containing tooth GO:0042475 9.72 TGFB1 SCN10A NF2
5 MAPK cascade GO:0000165 9.72 TGFB1 SOS1 RET GDNF FGF2
6 axon guidance GO:0007411 9.65 SOS1 SEMA3F SEMA3A RET GDNF
7 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.61 TGFB1 IL6
8 lens fiber cell differentiation GO:0070306 9.61 TGFB1 NF2
9 ureteric bud development GO:0001657 9.61 TGFB1 RET GDNF
10 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.6 NGF MGMT
11 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.58 SEMA3F SEMA3A
12 sympathetic ganglion development GO:0061549 9.58 SEMA3F SEMA3A
13 axon extension involved in axon guidance GO:0048846 9.57 SEMA3F SEMA3A
14 facial nerve structural organization GO:0021612 9.56 SEMA3F SEMA3A
15 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.54 SEMA3F SEMA3A
16 branchiomotor neuron axon guidance GO:0021785 9.52 SEMA3F SEMA3A
17 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.51 SEMA3F SEMA3A
18 positive regulation of gene expression GO:0010628 9.5 TGFB1 RET NGF IL6 FGF2 ANK3
19 sympathetic neuron projection guidance GO:0097491 9.49 SEMA3F SEMA3A
20 sympathetic neuron projection extension GO:0097490 9.48 SEMA3F SEMA3A
21 trigeminal nerve structural organization GO:0021637 9.46 SEMA3F SEMA3A
22 ventral trunk neural crest cell migration GO:0036486 9.37 SEMA3F SEMA3A
23 nerve development GO:0021675 9.33 SEMA3F SEMA3A NGF
24 neural crest cell migration GO:0001755 8.92 SEMA3F SEMA3A RET GDNF

Molecular functions related to Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.02 TGFB1 NGF IL6 GDNF FGF2
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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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