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NMO
MCID: NRM001
MIFTS: 66

Neuromyelitis Optica (NMO)

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Neuromyelitis Optica

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MalaCards integrated aliases for Neuromyelitis Optica:

Name: Neuromyelitis Optica 39 12 54 26 55 60 38 56 45 15 17 74
Devic Syndrome 77 54 26
Devic Disease 54 26 60
Devic's Syndrome 12 55
Devic's Disease 12 26
Opticospinal Multiple Sclerosis 74
Devic's Neuromyelitis Optica 54
Devic Neuromyelitis Optica 26
Nmo Spectrum Disorder 54
Optic-Spinal Ms 26
Opticospinal Ms 26
Nmo 54

Characteristics:

Orphanet epidemiological data:

60
neuromyelitis optica
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare neurological diseases
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:8869
KEGG 38 H01491
ICD9CM 36 341.0
MeSH 45 D009471
NCIt 51 C84934
SNOMED-CT 69 25044007
ICD10 34 G36.0
MESH via Orphanet 46 D009471
ICD10 via Orphanet 35 G36.0
UMLS via Orphanet 75 C0027873
Orphanet 60 ORPHA71211
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Summaries for Neuromyelitis Optica

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NINDS : 55 Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system (CNS) that predominantly affects the optic nerves and spinal cord. It is sometimes also referred to as NMO spectrum disorder. In NMO, the body's immune system mistakenly attacks healthy cells and proteins in the body, most often those in the spinal cord and eyes. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss. Individuals also develop transverse myelitis, which causes weakness or paralysis of arms and legs,and numbness, along with loss of bladder and bowel control. Magnetic resonance imaging of the spine often shows an abnormality that extends over long segments of the spinal cord. Individuals may also develop episodes of severe nausea and vomiting, with hiccups from involvement of a part of the brain that controls vomiting. The disease is caused by abnormal autoantibodies that bind to a protein called aquaporin-4. Binding of the aquaporin-4 antibody activates other components of the immune system, causing inflammation and damage to these cells. This also results in the brain and spinal cord the loss of myelin, the fatty substance that acts as insulation around nerve fibers and helps nerve signals move from cell to cell.  NMO is different from multiple sclerosis (MS). Attacks are usually more severe in NMO than in MS, and NMO is treated differently than MS. Most individuals with NMO experience clusters of attacks days to months or years apart, followed by partial recovery during periods of remission. Women are more often affected by NMO than men. African Americans are at greater risk of the disease than are Caucasians. The onset of NMO varies from childhood to adulthood, with two peaks, one in childhood and the other in adults in their 40s.

MalaCards based summary : Neuromyelitis Optica, also known as devic syndrome, is related to neuritis and optic neuritis. An important gene associated with Neuromyelitis Optica is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Mitoxantrone and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, brain and spinal cord, and related phenotypes are visual loss and peripheral demyelination

Disease Ontology : 12 A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).

Genetics Home Reference : 26 Neuromyelitis optica is an autoimmune disorder that affects the nerves of the eyes and the central nervous system, which includes the brain and spinal cord. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In neuromyelitis optica, the autoimmune attack causes inflammation of the nerves, and the resulting damage leads to the signs and symptoms of the condition.

NIH Rare Diseases : 54 Neuromyelitis optica is an autoimmune disease that affects the spinal cord and optic nerves (nerves that carry visual messages to and from the brain). In neuromyelitis optica, the body's immune system mistakenly attacks healthy cells and a substance called myelin in the spinal cord and eyes. Symptoms may begin in childhood or adulthood. Spinal cord involvement results in transverse myelitis, which may cause pain, paralysis and abnormal sensations in the spine and limbs. Bladder and bowel problems may also develop. Symptoms from optic nerve involvement include eye pain and vision loss from optic neuritis. Other symptoms of neuromyelitis optica may include episodes of nausea, vomiting, and hiccups. Some people have episodes of symptoms months or years apart (the relapsing form), while others have a single episode lasting several months (the monophasic form). In either form, people with neuromyelitis optica often develop permanent muscle weakness and vision loss. The cause of the immune system dysfunction leading to neuromyelitis optica is not known. It usually occurs in only one person in a family. There is no cure, but there are therapies to reduce symptoms during episodes and prevent relapses.

Wikipedia : 77 Neuromyelitis optica (NMO), also known as Devic''s disease or Devic''s syndrome, is a heterogeneous... more...

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Related Diseases for Neuromyelitis Optica

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Diseases in the Neuromyelitis Optica family:

Neuromyelitis Optica Spectrum Disorder

Diseases related to Neuromyelitis Optica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 neuritis 31.7 AQP4 MBP MOG
2 optic neuritis 31.5 AQP4 HLA-DRB1 MBP MOG
3 encephalitis 31.1 AQP4 GFAP MOG
4 transverse myelitis 31.1 AQP4 IL17A IL6 MBP
5 optic nerve disease 31.0 AQP4 MBP MOG
6 allergic encephalomyelitis 30.8 MBP MOG
7 acute transverse myelitis 30.7 AQP4 IL6
8 multiple sclerosis 30.7 AQP4 GFAP HLA-DRB1 IL17A IL6 MBP
9 demyelinating disease 30.7 AQP4 IL17A MBP MOG
10 myelitis 30.6 AQP4 HLA-DPB1 IL17A IL6 MBP MOG
11 hypersomnia 30.5 HCRT HLA-DRB1
12 narcolepsy 30.4 HCRT HLA-DRB1 MOG
13 peripheral nervous system disease 30.4 AQP4 IL6 MBP MOG
14 panencephalitis, subacute sclerosing 30.4 MBP MOG
15 wernicke encephalopathy 30.4 GFAP SLC1A2
16 radiculopathy 30.3 IL17A IL6
17 relapsing-remitting multiple sclerosis 30.3 AQP4 IL17A MBP MOG
18 acute disseminated encephalomyelitis 30.3 AQP4 HCRT HLA-DRB1 MBP MOG
19 internuclear ophthalmoplegia 30.2 AQP4 HCRT MBP MOG
20 systemic lupus erythematosus 30.2 HLA-DPB1 HLA-DRB1 IL17A IL6 TNFSF13B
21 connective tissue disease 30.1 HLA-DPB1 HLA-DRB1 IL6 TNFSF13B
22 autoimmune disease 30.1 HLA-DRB1 IL17A IL6 MBP MOG TNFSF13B
23 takayasu arteritis 30.0 HLA-DPB1 HLA-DRB1 IL6
24 brain injury 29.8 GFAP IL6 MBP S100B
25 primary progressive multiple sclerosis 29.8 HLA-DRB1 MBP MOG S100B
26 neuromyelitis optica spectrum disorder 12.7
27 marburg acute multiple sclerosis 11.4
28 lupus erythematosus 10.6
29 sjogren syndrome 10.6
30 myasthenia gravis 10.5
31 myasthenia gravis congenital 10.5
32 neuropathy 10.5
33 distal trisomy 3p 10.4
34 alexia 10.4 AQP4 MBP
35 chiari malformation 10.4 GFAP MBP
36 autoimmune disease 1 10.4
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
38 depression 10.4
39 encephalopathy 10.4
40 obstructive hydrocephalus 10.4 AQP4 GFAP
41 anca-associated vasculitis 10.3 HLA-DRB1 IL6
42 pediatric multiple sclerosis 10.3 HLA-DRB1 MOG
43 celiac disease 1 10.3
44 hematopoietic stem cell transplantation 10.3
45 hepatitis 10.3
46 adenocarcinoma 10.3
47 rheumatoid arthritis, systemic juvenile 10.3 HLA-DRB1 IL6
48 ascaris lumbricoides infection 10.3 IL6 TNFSF13B
49 neuroretinitis 10.3 AQP4 MOG
50 narcolepsy 2 10.3 HCRT HLA-DRB1

Graphical network of the top 20 diseases related to Neuromyelitis Optica:



Diseases related to Neuromyelitis Optica
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Symptoms & Phenotypes for Neuromyelitis Optica

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Human phenotypes related to Neuromyelitis Optica:

60 33 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 visual loss 60 33 hallmark (90%) Very frequent (99-80%) HP:0000572
2 peripheral demyelination 60 33 hallmark (90%) Very frequent (99-80%) HP:0011096
3 sensory impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0003474
4 optic neuritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100653
5 ocular pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0200026
6 autoimmune antibody positivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0030057
7 neuronal loss in central nervous system 60 33 hallmark (90%) Very frequent (99-80%) HP:0002529
8 paraplegia 60 33 hallmark (90%) Very frequent (99-80%) HP:0010550
9 functional abnormality of the bladder 60 33 hallmark (90%) Very frequent (99-80%) HP:0000009
10 myelitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0012486
11 abnormality of brain morphology 60 33 frequent (33%) Frequent (79-30%) HP:0012443
12 recurrent singultus 60 33 occasional (7.5%) Occasional (29-5%) HP:0100247
13 respiratory failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0002878
14 nausea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002018
15 csf pleocytosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012229

MGI Mouse Phenotypes related to Neuromyelitis Optica:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 AQP1 AQP4 GFAP HCRT IL6 MBP
2 growth/size/body region MP:0005378 9.81 AQP1 AQP4 GFAP HCRT IL17A IL6
3 hematopoietic system MP:0005397 9.56 AQP1 AQP4 CD59 IL17A IL6 MBP
4 homeostasis/metabolism MP:0005376 9.32 AQP1 AQP4 CD59 GFAP HCRT IL17A
Sources

Drugs & Therapeutics for Neuromyelitis Optica

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Drugs for Neuromyelitis Optica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2
Mycophenolic acid Approved Phase 4 24280-93-1 446541
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Analgesics Phase 4
6 Topoisomerase Inhibitors Phase 4
7 Antitubercular Agents Phase 4
8 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
9 Antibiotics, Antitubercular Phase 4
10 Hormones Phase 4,Phase 3,Phase 2,Phase 1
11 Anti-Infective Agents Phase 4
12 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
13 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
14 Anti-Bacterial Agents Phase 4
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
17
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Phase 1 2921-57-5
18
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 83-43-2 6741
19
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Phase 1 50-24-8 5755
20
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Phase 1 302-25-0
21
rituximab Approved Phase 2, Phase 3,Phase 3,Phase 1 174722-31-7 10201696
22
Azathioprine Approved Phase 2, Phase 3,Phase 3 446-86-6 2265
23
Mesna Approved, Investigational Phase 2, Phase 3,Phase 1 3375-50-6 598
24
Ifosfamide Approved Phase 2, Phase 3,Phase 1 3778-73-2 3690
25
Sargramostim Approved, Investigational Phase 2, Phase 3 123774-72-1, 83869-56-1
26
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 1 135968-09-1
27
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 6055-19-2, 50-18-0 2907
28
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Phase 1 2920-86-7
29 Methylprednisolone Acetate Phase 3,Phase 2,Phase 1
30 Neuroprotective Agents Phase 3,Phase 2,Phase 1
31 Protective Agents Phase 3,Phase 2,Phase 1
32 Antiemetics Phase 3,Phase 2,Phase 1
33 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
34 Prednisolone acetate Phase 3,Phase 2,Phase 1
35 Autonomic Agents Phase 3,Phase 2,Phase 1
36 Immunologic Factors Phase 2, Phase 3,Phase 3,Phase 1
37 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
38 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
39 Antineoplastic Agents, Immunological Phase 2, Phase 3,Phase 3,Phase 1
40 Antimetabolites Phase 2, Phase 3,Phase 3
41 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1
42 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
43 Antirheumatic Agents Phase 2, Phase 3,Phase 3,Phase 1
44 Rho(D) Immune Globulin Phase 2, Phase 3,Phase 3
45 Immunoglobulins, Intravenous Phase 2, Phase 3,Phase 3
46 gamma-Globulins Phase 2, Phase 3,Phase 3
47 Immunoglobulin G Phase 3,Phase 2
48 Antibodies, Monoclonal Phase 2, Phase 3,Phase 3,Phase 1
49 Alkylating Agents Phase 2, Phase 3,Phase 1
50
Isophosphamide mustard Phase 2, Phase 3,Phase 1 0

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
2 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
3 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
4 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
5 Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
6 A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study) Completed NCT01892345 Phase 3 Eculizumab
7 A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders Recruiting NCT03330418 Phase 3
8 Autologous Transplant To End NMO Spectrum Disorder Recruiting NCT03829566 Phase 2, Phase 3 Rituximab;Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
9 Tocilizumab vs Azathioprine in Neuromyelitis Optica Spectrum Disorders Active, not recruiting NCT03350633 Phase 2, Phase 3 Tocilizumab Injection;Azathioprine
10 A Double-masked, Placebo-controlled Study With Open Label Period to Evaluate MEDI-551 in Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders Active, not recruiting NCT02200770 Phase 2, Phase 3
11 An Open Label Extension Trial of Eculizumab in Relapsing NMO Patients Active, not recruiting NCT02003144 Phase 3
12 Efficacy and Safety Study as Monotherapy of Satralizumab (SA237) to Treat NMO and NMOSD Active, not recruiting NCT02073279 Phase 3 satralizumab (SA237);Placebo
13 Efficacy and Safety Study as Add-on Therapy of Satralizumab (SA237) to Treat NMO and NMOSD Active, not recruiting NCT02028884 Phase 3 satralizumab (SA237);Placebo
14 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
15 Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica Unknown status NCT01364246 Phase 1, Phase 2
16 Neuromyelitis Optica (NMO) & Cetirizine Completed NCT02865018 Phase 1, Phase 2 cetirizine
17 An Open Label Study of the Effects of Eculizumab in Neuromyelitis Optica Completed NCT00904826 Phase 1, Phase 2 Eculizumab
18 Phase II Clinical Trial of NPB-01 in Patients With Anti-aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorder Not Provided Adequate Effect of Therapy to Steroids Plus Therapy. Completed NCT01845584 Phase 2 NPB-01
19 Efficacy and Safety of Bortezomib as add-on Treatment in Relapsing Neuromyelitis Optica Spectrum Disorder Completed NCT02893111 Phase 2 Bortezomib
20 Autologous Mesenchymal Stem Cells for the Treatment of Neuromyelitis Optica Spectrum Disorders Completed NCT02249676 Phase 2
21 A Longitudinal Study of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active NMOSD Completed NCT03062579 Phase 1, Phase 2 Tocilizumab
22 Safety and Efficacy of Sustained Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
23 Hematopoietic Stem Cell Transplant in Devic's Disease Active, not recruiting NCT00787722 Phase 1, Phase 2 Cyclophosphamide;G-CSF;rATG;Mesna;Rituximab;Methylprednisolone
24 Autologous Hematopoietic Stem Cell Transplant in Neuromyelitis Optica Terminated NCT01339455 Phase 1, Phase 2
25 Pilot Study of alpha1-antitrypsin to Treat Neuromyelitis Optica Relapses Unknown status NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
26 C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
27 Safety and Tolerability of Rituximab in Neuromyelitis Optica Completed NCT00501748 Phase 1 Rituximab
28 Efficacy of Bevacizumab (Avastin) in Treatment of Acute NMO Exacerbations Completed NCT01777412 Phase 1 Bevacizumab
29 Central Pain Study for ABX-1431 Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
30 Treatment of Multiple Sclerosis and Neuromyelitis Optica With Regulatory Dendritic Cell: Clinical Trial Phase 1 B Recruiting NCT02283671 Phase 1
31 Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses Active, not recruiting NCT02276963 Phase 1 Ublituximab
32 Treatment of Relapsed and/or Refractory AQP4-IgG Seropositive NMOSD by Tandem CAR T Cells Targeting CD19 and CD20 Not yet recruiting NCT03605238 Phase 1
33 Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct Unknown status NCT01024985
34 Maintenance Plasma Exchange for Neuromyelitis Optica Unknown status NCT01500681
35 The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset Unknown status NCT02886377
36 Quantitation of McArdle's Sign and Evaluation of Specificity for Multiple Sclerosis Completed NCT03122873
37 Pathologic-MRI Findings in Atypical IIDD Completed NCT03121105
38 Multimodel Magnetic Resonance Imaging (MRI)of Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders Recruiting NCT02836327
39 The French Cohort and Biobank of Devic's Neuromyelitis Optica and Related Neurological Disorders (NMOSD) (NOMADMUS) Recruiting NCT02850705
40 Pediatric NMOSD Observational Study Recruiting NCT03766347
41 The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
42 The French Multiple Sclerosis Registry Recruiting NCT02889965
43 Analysis of the Distribution of Regulatory B Cells in Blood of Multiple Sclerosis Patients Recruiting NCT02789670
44 Stem Cell Ophthalmology Treatment Study II Recruiting NCT03011541 Not Applicable
45 Scrambler Trial for Pain in NMOSD Active, not recruiting NCT03452176 Not Applicable
46 Biobank For MS And Other Demyelinating Diseases Active, not recruiting NCT00445367
47 Optical Coherence Tomography and Optic Neuritis (OCTON) Active, not recruiting NCT02573792
48 Clinic Registry Study of Optic Neuromyelitis Spectrum Disease in China Enrolling by invitation NCT03514030
49 Stem Cell Ophthalmology Treatment Study Enrolling by invitation NCT01920867 Not Applicable
50 Clinical Patterns of Neuromyelitis Optica Spectrum Disorders in Assiut University Hospital Not yet recruiting NCT03819413

Search NIH Clinical Center for Neuromyelitis Optica

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neuromyelitis Optica cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neuromyelitis Optica:
Allogeneic hematopoietic stem cells for the treatment of neuromyelitis optica
Hematopoetic stem cells for treatment of neuromyelitis optica
NU211-01/NU215-02, umbilical cord mesenchymal stem cells for multiple sclerosis and neuromyelitis optica
Embryonic/Adult Cultured Cells Related to Neuromyelitis Optica:
Peripheral blood-derived hematopoietic stem cells
Peripheral blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells PMIDs: 20682053

Cochrane evidence based reviews: neuromyelitis optica

Sources

Genetic Tests for Neuromyelitis Optica

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Sources

Anatomical Context for Neuromyelitis Optica

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MalaCards organs/tissues related to Neuromyelitis Optica:

42
Brain, Spinal Cord, Eye, T Cells, B Cells, Testes, Neutrophil
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neuromyelitis Optica:
# Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
Sources

Publications for Neuromyelitis Optica

About this section

Articles related to Neuromyelitis Optica:

(show top 50) (show all 2017)
# Title Authors Year
1
Brain MRI Findings in Pediatric-Onset Neuromyelitis Optica Spectrum Disorder: Challenges in Differentiation from Acute Disseminated Encephalomyelitis. ( 30846436 )
2019
2
Neuromyelitis optica: an elusive cause of dysphagia. ( 30642856 )
2019
3
Limbic encephalitis-like presentation in neuromyelitis optica spectrum disorder: a case report. ( 30835052 )
2019
4
Hypertrophic olivary degeneration mimics relapse in neuromyelitis optica spectrum disorder. ( 30745445 )
2019
5
A case of neuromyelitis optica spectrum disorder following seasonal influenza vaccination. ( 30769255 )
2019
6
Coexistence of Neuromyelitis Optica and Amyotrophic Lateral Sclerosis: A Case Report. ( 30671163 )
2019
7
A Little-Known Brain Imaging Feature in Neuromyelitis Optica Spectrum Disorder: A Leukodystrophy-Like Pattern. ( 30877700 )
2019
8
Can Visual Testing Be Used to Distinguish Neuromyelitis Optica and Multiple Sclerosis? ( 30803517 )
2019
9
Comparison of Ocular Motor Findings Between Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis Involving the Brainstem and Cerebellum. ( 30827013 )
2019
10
Association of Optic Neuritis with Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis in Korea. ( 30746915 )
2019
11
Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder. ( 30770971 )
2019
12
The Role of B Cells and Antibodies in Multiple Sclerosis, Neuromyelitis Optica, and Related Disorders. ( 30800132 )
2019
13
Immunoadsorption or plasma exchange in steroid-refractory multiple sclerosis and neuromyelitis optica. ( 30698295 )
2019
14
Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. ( 30663608 )
2019
15
Peripheral CD19+ B-cell counts and infusion intervals as a surrogate for long-term B-cell depleting therapy in multiple sclerosis and neuromyelitis optica/neuromyelitis optica spectrum disorders. ( 30377816 )
2019
16
Plasma exchange: an effective add-on treatment of optic neuritis in neuromyelitis optica spectrum disorders. ( 30825049 )
2019
17
Neuromyelitis optica spectrum disorder coincident with renal clear cell carcinoma: A case report. ( 30732138 )
2019
18
Suspected bacterial meningoencephalomyelitis as the trigger or presentation of neuromyelitis optica spectrum disorder flare. ( 30738276 )
2019
19
Intra-family phenotype variations in familial neuromyelitis optica spectrum disorders. ( 30738281 )
2019
20
The expansion of circulating IL-6 and IL-17-secreting follicular helper T cells is associated with neurological disabilities in neuromyelitis optica spectrum disorders. ( 30769212 )
2019
21
Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder. ( 30769213 )
2019
22
Foxp3+ regulatory T cells expression in neuromyelitis optica spectrum disorders. ( 30771576 )
2019
23
Clinical course of neuromyelitis optica spectrum disorder in a moroccan cohort. ( 30772672 )
2019
24
Rituximab during pregnancy in neuromyelitis optica: A case report. ( 30800724 )
2019
25
Clinical characteristics of myelin oligodendrocyte glycoprotein antibody neuromyelitis optica spectrum disorder. ( 30825703 )
2019
26
Effectiveness of rituximab in neuromyelitis optica: a meta-analysis. ( 30841862 )
2019
27
Predictive value of conventional MRI parameters in first spinal attacks of neuromyelitis optica spectrum disorder. ( 30843448 )
2019
28
CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica. ( 30851734 )
2019
29
Interleukin-36 alpha levels are elevated in the serum and cerebrospinal fluid of patients with neuromyelitis optica spectrum disorder and correlate with disease activity. ( 30852049 )
2019
30
Neuromyelitis optica spectrum disorder associated with Zika virus infection. ( 30859012 )
2019
31
Neuromyelitis optica spectrum disorders. ( 30872305 )
2019
32
Seronegative neuromyelitis optica spectrum disorder: severe polysymptomatic presentation with successful treatment response. ( 30878968 )
2019
33
Bilateral extensive lesions of the brain in a patient with neuromyelitis optica manifested with seizure and cognitive impairments. ( 30879604 )
2019
34
Quantitative 7T MRI does not detect occult brain damage in neuromyelitis optica. ( 30882018 )
2019
35
Neuromyelitis optica after splenectomy: A secondary autoimmune phenomenon. ( 30884276 )
2019
36
The neuromyelitis optica presentation in HIV seropositive patients. ( 30885372 )
2019
37
Commentary on the manuscript "the neuromyelitis optica presentation in HIV seropositive patients". ( 30885373 )
2019
38
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations. ( 30887238 )
2019
39
Autonomic dysfunction in people with neuromyelitis optica spectrum disorders. ( 30887872 )
2019
40
Non-target metabolomics profiling of neuromyelitis optica spectrum disorder. ( 30891765 )
2019
41
Neuromyelitis optica spectrum disorders: still evolving and broadening. ( 30893099 )
2019
42
Neuromyelitis Optica with Lesions Involving the Optic Nerves, the Optic Chiasm, and the Optic Tracts. ( 30897583 )
2019
43
So Dramatic They Could Never Be Overlooked: History of Pediatric Neuromyelitis Optica. ( 30898412 )
2019
44
Two Cases of Pediatric AQP4-Antibody Positive Neuromyelitis Optica Spectrum Disorder Successfully Treated with Tocilizumab. ( 30913570 )
2019
45
Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound. ( 30500945 )
2019
46
Association of GTF2IRD1-GTF2I polymorphisms with neuromyelitis optica spectrum disorders in Han Chinese patients. ( 30531019 )
2019
47
Myelin oligodendrocyte glycoprotein antibodies in neuromyelitis optica spectrum disorder. ( 30562266 )
2019
48
Erratum: Plasmapheresis for acute attacks in neuromyelitis optica spectrum disorders. ( 30568996 )
2019
49
Pharmacotherapy for Neuromyelitis Optica Spectrum Disorders: Current Management and Future Options. ( 30623348 )
2019
50
Clinical course, treatment responses and outcomes in Chinese paediatric neuromyelitis optica spectrum disorder. ( 30623860 )
2019
Sources

Variations for Neuromyelitis Optica

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Expression for Neuromyelitis Optica

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Search GEO for disease gene expression data for Neuromyelitis Optica.
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Pathways for Neuromyelitis Optica

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Pathways related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 38
Show member pathways
 12.51 HLA-DPB1 HLA-DRB1 IL17A IL6 TNFSF13B
2
Th17 cell differentiation 38
Show member pathways
 12.24 HLA-DPB1 HLA-DRB1 IL17A IL6
3
Neuroscience 4
12.19 GFAP HCRT MBP S100B SLC1A2
4
Tuberculosis 38
11.89 HLA-DPB1 HLA-DRB1 IL6
5
Hematopoietic cell lineage 38
11.44 CD59 HLA-DPB1 HLA-DRB1 IL6
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.4 GFAP MOG S100B
7
Rheumatoid arthritis 38
11.31 HLA-DPB1 HLA-DRB1 IL17A IL6 TNFSF13B
8
Spinal Cord Injury 1
11.18 AQP1 AQP4 GFAP IL6 MBP TNFSF13B
9
Cytokines and Inflammatory Response 1
10.9 HLA-DRB1 IL6
10
G-protein signaling_RhoB regulation pathway 23
10.88 IL17A IL6 TNFSF13B
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GO Terms for Neuromyelitis Optica

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Cellular components related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 AQP4 HLA-DRB1 IL17A MOG
2 cell surface GO:0009986 9.35 CD59 HLA-DPB1 HLA-DRB1 MBP SLC1A2
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.32 HLA-DPB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 9.26 HLA-DPB1 HLA-DRB1
5 ER to Golgi transport vesicle membrane GO:0012507 8.8 CD59 HLA-DPB1 HLA-DRB1

Biological processes related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.76 HCRT IL17A IL6 TNFSF13B
2 T cell receptor signaling pathway GO:0050852 9.58 HLA-DPB1 HLA-DRB1 MOG
3 central nervous system development GO:0007417 9.5 MBP MOG S100B
4 positive regulation of interleukin-6 secretion GO:2000778 9.48 IL17A MBP
5 water transport GO:0006833 9.43 AQP1 AQP4
6 positive regulation of glial cell proliferation GO:0060252 9.37 GFAP IL6
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DPB1 HLA-DRB1
8 multicellular organismal water homeostasis GO:0050891 9.16 AQP1 AQP4
9 positive regulation of T cell proliferation GO:0042102 9.13 HLA-DPB1 IL6 TNFSF13B
10 immune response GO:0006955 9.1 HLA-DPB1 HLA-DRB1 IL17A IL6 MBP TNFSF13B

Molecular functions related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 AQP1 AQP4
2 water channel activity GO:0015250 8.96 AQP1 AQP4
3 water transmembrane transporter activity GO:0005372 8.62 AQP1 AQP4
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Sources for Neuromyelitis Optica

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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