NMO
MCID: NRM001
MIFTS: 60

Neuromyelitis Optica (NMO)

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Neuromyelitis Optica

MalaCards integrated aliases for Neuromyelitis Optica:

Name: Neuromyelitis Optica 12 52 25 53 58 36 54 43 15 37 17 71
Devic Syndrome 74 52 25
Devic Disease 52 25 58
Devic's Syndrome 12 53
Devic's Disease 12 25
Opticospinal Multiple Sclerosis 71
Devic's Neuromyelitis Optica 52
Devic Neuromyelitis Optica 25
Nmo Spectrum Disorder 52
Optic-Spinal Ms 25
Opticospinal Ms 25
Nmo 52

Characteristics:

Orphanet epidemiological data:

58
neuromyelitis optica
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:8869
KEGG 36 H01491
ICD9CM 34 341.0
MeSH 43 D009471
NCIt 49 C84934
SNOMED-CT 67 25044007
ICD10 32 G36.0
MESH via Orphanet 44 D009471
ICD10 via Orphanet 33 G36.0
UMLS via Orphanet 72 C0027873
Orphanet 58 ORPHA71211
UMLS 71 C0027873 C3711850

Summaries for Neuromyelitis Optica

Genetics Home Reference : 25 Neuromyelitis optica is an autoimmune disorder that affects the nerves of the eyes and the central nervous system, which includes the brain and spinal cord. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In neuromyelitis optica, the autoimmune attack causes inflammation of the nerves, and the resulting damage leads to the signs and symptoms of the condition. Neuromyelitis optica is characterized by optic neuritis, which is inflammation of the nerve that carries information from the eye to the brain (optic nerve). Optic neuritis causes eye pain and vision loss, which can occur in one or both eyes. Neuromyelitis optica is also characterized by transverse myelitis, which is inflammation of the spinal cord. The inflammation associated with transverse myelitis damages the spinal cord, causing a lesion that often extends the length of three or more bones of the spine (vertebrae). In addition, myelin, which is the covering that protects nerves and promotes the efficient transmission of nerve impulses, can be damaged. Transverse myelitis causes weakness, numbness, and paralysis of the arms and legs. Other effects of spinal cord damage can include disturbances in sensations, loss of bladder and bowel control, uncontrollable hiccupping, and nausea. In addition, muscle weakness may make breathing difficult and can cause life-threatening respiratory failure in people with neuromyelitis optica. There are two forms of neuromyelitis optica, the relapsing form and the monophasic form. The relapsing form is most common. This form is characterized by recurrent episodes of optic neuritis and transverse myelitis. These episodes can be months or years apart, and there is usually partial recovery between episodes. However, most affected individuals eventually develop permanent muscle weakness and vision impairment that persist even between episodes. For unknown reasons, approximately nine times more women than men have the relapsing form. The monophasic form, which is less common, causes a single episode of neuromyelitis optica that can last several months. People with this form of the condition can also have lasting muscle weakness or paralysis and vision loss. This form affects men and women equally. The onset of either form of neuromyelitis optica can occur anytime from childhood to adulthood, although the condition most frequently begins in a person's forties. Approximately one-quarter of individuals with neuromyelitis optica have signs or symptoms of another autoimmune disorder such as myasthenia gravis, systemic lupus erythematosus, or Sjögren syndrome. Some scientists believe that a condition described in Japanese patients as optic-spinal multiple sclerosis (or opticospinal multiple sclerosis) that affects the nerves of the eyes and central nervous system is the same as neuromyelitis optica.

MalaCards based summary : Neuromyelitis Optica, also known as devic syndrome, is related to neuromyelitis optica spectrum disorder and optic neuritis. An important gene associated with Neuromyelitis Optica is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Mycophenolic acid and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, brain and spinal cord, and related phenotypes are visual loss and peripheral demyelination

Disease Ontology : 12 A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis).

NIH Rare Diseases : 52 Neuromyelitis optica is an autoimmune disease that affects the spinal cord and optic nerves (nerves that carry visual messages to and from the brain). In neuromyelitis optica, the body's immune system mistakenly attacks healthy cells and a substance called myelin in the spinal cord and eyes. Symptoms may begin in childhood or adulthood. Spinal cord involvement results in transverse myelitis , which may cause pain, paralysis and abnormal sensations in the spine and limbs. Bladder and bowel problems may also develop. Symptoms from optic nerve involvement include eye pain and vision loss from optic neuritis . Other symptoms of neuromyelitis optica may include episodes of nausea, vomiting, and hiccups. Some people have episodes of symptoms months or years apart (the relapsing form), while others have a single episode lasting several months (the monophasic form). In either form, people with neuromyelitis optica often develop permanent muscle weakness and vision loss. The cause of the immune system dysfunction leading to neuromyelitis optica is not known. It usually occurs in only one person in a family. There is no cure, but there are therapies to reduce symptoms during episodes and prevent relapses.

NINDS : 53 Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system (CNS) that predominantly affects the optic nerves and spinal cord. It is sometimes also referred to as NMO spectrum disorder. In NMO, the body's immune system mistakenly attacks healthy cells and proteins in the body, most often those in the spinal cord and eyes. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss. Individuals also develop transverse myelitis, which causes weakness or paralysis of arms and legs,and numbness, along with loss of bladder and bowel control. Magnetic resonance imaging of the spine often shows an abnormality that extends over long segments of the spinal cord. Individuals may also develop episodes of severe nausea and vomiting, with hiccups from involvement of a part of the brain that controls vomiting. The disease is caused by abnormal autoantibodies that bind to a protein called aquaporin-4. Binding of the aquaporin-4 antibody activates other components of the immune system, causing inflammation and damage to these cells. This also results in the brain and spinal cord the loss of myelin, the fatty substance that acts as insulation around nerve fibers and helps nerve signals move from cell to cell.  NMO is different from multiple sclerosis (MS). Attacks are usually more severe in NMO than in MS, and NMO is treated differently than MS. Most individuals with NMO experience clusters of attacks days to months or years apart, followed by partial recovery during periods of remission. Women are more often affected by NMO than men. African Americans are at greater risk of the disease than are Caucasians. The onset of NMO varies from childhood to adulthood, with two peaks, one in childhood and the other in adults in their 40s.

KEGG : 36 Neuromyelitis optica (NMO), also known as Devic's disease is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. The etiology of NMO is unknown but it is believed to be an autoimmune disorder triggered by an environmental factor, possibly an infection, in genetically susceptible individuals. The principal effector in NMO is the self-reactive, complement-activating anti-AQP4 antibody. AQP4 water channel is a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. Anti-AQP4 antibody is sensitive and highly specific serum markers of autoimmune NMO. For many decades, NMO was considered to be a subtype of multiple sclerosis (MS), but prognosis and optimal treatments differ. Corticosteroids and plasma exchange (PLEX) are the most commonly used therapeutic modalities in acute settings. Corticosteroids exert global immunosuppressive and anti-inflammatory effects, whereas PLEX removes antibodies, complement, and cytokines from the blood. Besides, immunosuppressant agents interfering with the function of T and B cells have been shown to prevent disease relapses and reduce neurological disability in NMO.

Wikipedia : 74 Neuromyelitis optica (NMO) is a heterogeneous condition consisting of the inflammation and demyelination... more...

Related Diseases for Neuromyelitis Optica

Diseases in the Neuromyelitis Optica family:

Neuromyelitis Optica Spectrum Disorder

Diseases related to Neuromyelitis Optica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 633)
# Related Disease Score Top Affiliating Genes
1 neuromyelitis optica spectrum disorder 35.0 CD27 AQP4
2 optic neuritis 33.1 MOG MBP HLA-DRB1 GFAP CXCL10 AQP4
3 transverse myelitis 32.1 MBP IL6 IL17A CD27 AQP4
4 acute transverse myelitis 31.9 IL6 AQP4
5 allergic encephalomyelitis 31.7 MOG MBP
6 neuritis 31.6 MOG MBP IL6 IL4 GFAP CXCL10
7 acute disseminated encephalomyelitis 31.5 MOG MBP HLA-DRB1 CD40LG AQP4
8 spinal cord injury 31.3 IL6 GFAP AQP4
9 myelitis 31.3 MOG MBP IL6 IL17A HLA-DPB1 CD40LG
10 systemic autoimmune disease 31.2 IL6 IL17A
11 lupus erythematosus 31.2 HLA-DRB1 HLA-DPB1 FCRL3 CD40LG
12 sjogren syndrome 31.1 TNFSF13B CXCL13 CD40LG AQP5
13 myasthenia gravis 31.1 TNFSF13B MBP IL4 HLA-DPB1
14 internuclear ophthalmoplegia 31.1 MOG AQP4
15 central nervous system disease 31.1 MOG MBP IL6 IL17A GFAP
16 pediatric multiple sclerosis 31.1 MOG HLA-DRB1
17 acute retrobulbar neuritis 31.0 MBP AQP4
18 vasculitis 31.0 TNFSF13B IL6 IL17A CD40LG
19 hydrocephalus 31.0 S100B MBP GFAP AQP4
20 chickenpox 31.0 IL6 IL4 CD40LG CD27
21 meningoencephalitis 31.0 MBP IL6 CD40LG
22 pulmonary tuberculosis 30.9 IL6 IL4 IL17A HLA-DRB1
23 optic papillitis 30.9 MOG CD40LG AQP4
24 neuroretinitis 30.9 CD40LG AQP4
25 guillain-barre syndrome 30.8 MOG MBP HLA-DRB1 CD40LG
26 syphilis 30.8 IL17A HLA-DRB1 CD40LG
27 autoimmune disease 30.8 TNFSF13B MOG MBP IL6 IL4 IL17A
28 balo concentric sclerosis 30.8 MOG MBP AQP4
29 encephalitis 30.8 MOG IL6 GFAP CXCL10 CD40LG AQP4
30 demyelinating disease 30.8 MOG MBP IL6 IL4 IL17A HLA-DRB1
31 aspiration pneumonia 30.7 IL6 IL17A CD40LG
32 asymptomatic neurosyphilis 30.7 CXCL13 CD40LG
33 optic nerve disease 30.7 MOG MBP IL6 IL17A GFAP CD40LG
34 narcolepsy 30.7 MOG IL6 HLA-DRB1 HLA-DPB1 GFAP AQP4
35 measles 30.6 IL6 HLA-DRB1 HLA-DPB1 CD40LG
36 hashimoto thyroiditis 30.6 IL6 IL4 IL17A HLA-DRB1
37 relapsing-remitting multiple sclerosis 30.6 TNFSF13B MOG MBP IL6 IL4 IL17A
38 bacterial meningitis 30.5 S100B IL6 IL17A AQP4
39 sarcoidosis 1 30.5 HLA-DRB1 CXCL10 CD40LG CD27
40 dermatitis herpetiformis 30.5 IL4 IL17A CD40LG
41 intracranial hypertension 30.5 CXCL10 AQP4 AQP1
42 sclerosing cholangitis 30.5 IL6 HLA-DRB1 CD40LG
43 purpura 30.5 TNFSF13B IL6 IL4 CD40LG
44 primary progressive multiple sclerosis 30.5 S100B MOG MBP IL4 HLA-DRB1
45 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 MBP IL17A HLA-DRB1 CD59
46 mixed connective tissue disease 30.5 TNFSF13B IL6 HLA-DRB1 CD40LG
47 opsoclonus-myoclonus syndrome 30.5 TNFSF13B CXCL10
48 proteasome-associated autoinflammatory syndrome 1 30.5 IL6 IL4 IL17A CXCL10
49 immunoglobulin alpha deficiency 30.4 TNFSF13B CD40LG CD27
50 polyneuropathy 30.4 MBP IL6 CD59 CD40LG

Graphical network of the top 20 diseases related to Neuromyelitis Optica:



Diseases related to Neuromyelitis Optica

Symptoms & Phenotypes for Neuromyelitis Optica

Human phenotypes related to Neuromyelitis Optica:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 visual loss 58 31 hallmark (90%) Very frequent (99-80%) HP:0000572
2 peripheral demyelination 58 31 hallmark (90%) Very frequent (99-80%) HP:0011096
3 sensory impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0003474
4 optic neuritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100653
5 neuronal loss in central nervous system 58 31 hallmark (90%) Very frequent (99-80%) HP:0002529
6 paraplegia 58 31 hallmark (90%) Very frequent (99-80%) HP:0010550
7 ocular pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0200026
8 autoimmune antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0030057
9 functional abnormality of the bladder 58 31 hallmark (90%) Very frequent (99-80%) HP:0000009
10 myelitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0012486
11 abnormality of brain morphology 58 31 frequent (33%) Frequent (79-30%) HP:0012443
12 recurrent singultus 58 31 occasional (7.5%) Occasional (29-5%) HP:0100247
13 respiratory failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0002878
14 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
15 csf pleocytosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012229

MGI Mouse Phenotypes related to Neuromyelitis Optica:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 CD27 CD40LG CD59 CXCL10 CXCL13 GFAP
2 hematopoietic system MP:0005397 9.97 AQP1 AQP4 CD27 CD40LG CD59 CXCL10
3 homeostasis/metabolism MP:0005376 9.77 AQP1 AQP4 AQP5 CD40LG CD59 CXCL10
4 immune system MP:0005387 9.4 AQP4 CD27 CD40LG CXCL10 CXCL13 GFAP

Drugs & Therapeutics for Neuromyelitis Optica

Drugs for Neuromyelitis Optica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4 24280-93-1 446541
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
4 Antitubercular Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Bacterial Agents Phase 4
8 Analgesics Phase 4
9 Topoisomerase Inhibitors Phase 4
10
Ravulizumab Approved, Investigational Phase 3 1803171-55-2
11
Azathioprine Approved Phase 3 446-86-6 2265
12 Antimetabolites Phase 2, Phase 3
13 Complement System Proteins Phase 3
14 Complement Inactivating Agents Phase 3
15 Vaccines Phase 3
16
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
17
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
18
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
19
Chlorpheniramine Approved Phase 2 113-92-8, 132-22-9 2725
20
Cetirizine Approved Phase 1, Phase 2 83881-51-0 2678
21
Histamine Approved, Investigational Phase 1, Phase 2 51-45-6 774
22
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
23
4-Aminopyridine Approved Phase 2 504-24-5 1727
24
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
25
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
26 Hydrocortisone hemisuccinate Phase 2
27 Hydrocortisone 17-butyrate 21-propionate Phase 2
28
protease inhibitors Phase 2
29 HIV Protease Inhibitors Phase 2
30 Neurotransmitter Agents Phase 1, Phase 2
31
Histamine Phosphate Phase 1, Phase 2 51-74-1 65513
32 Histamine Antagonists Phase 1, Phase 2
33 Histamine H1 Antagonists Phase 1, Phase 2
34 Histamine H1 Antagonists, Non-Sedating Phase 1, Phase 2
35 Anti-Allergic Agents Phase 1, Phase 2
36 Proteasome Inhibitors Phase 2
37 Potassium Channel Blockers Phase 2
38 Pharmaceutical Solutions Phase 2
39 BB 1101 Phase 1, Phase 2
40
Bevacizumab Approved, Investigational Phase 1 216974-75-3
41 Complement C1s Phase 1
42 Complement C1 Inhibitor Protein Phase 1
43 Complement C1 Inactivator Proteins Phase 1
44 Angiogenesis Inhibitors Phase 1
45
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
46 interferons
47 Adjuvants, Immunologic
48 Antiviral Agents
49 Radiation-Protective Agents
50 Interferon Inducers

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
2 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
3 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
4 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
5 Safety and Efficacy of Tocilizumab Versus Azathioprine in Neuromyelitis Optica Spectrum Disorders: a Randomized, Controlled, Open-label, Phase 2 Trial Completed NCT03350633 Phase 2, Phase 3 Tocilizumab Injection;Azathioprine
6 Comparison of Annual Relapse Rate, Expanded Disability Status Scale, and Side Effects Between Azathioprine and Rituximab in Patients With Neuromyelitis Optica Spectrum Disorders Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
7 Randomized Clinical Trial of Plasma Exchanges Versus Sham Plasma Exchanges in Disabling Multiple Sclerosis Acute Relapses Refractory to Steroid Treatment Completed NCT01442233 Phase 3
8 A Phase 3, External Placebo-Controlled, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Patients With Neuromyelitis Optica Spectrum Disorder (NMOSD) Recruiting NCT04201262 Phase 3
9 A Phase III Study of RC18, a Recombinant Human B Lymphocyte Stimulator Receptor:Immunoglobulin G( IgG ) Fc Fusion Protein for Injection for the Treatment of Subjects With Neuromyelitis Optica Spectrum Disorders. Recruiting NCT03330418 Phase 3
10 A Phase III, Open-label, Extension Trial of ECU-NMO-301 to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Active, not recruiting NCT02003144 Phase 3
11 A Multicenter, Randomized, Addition to Baseline Treatment, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Satralizumab (SA237) in Patients With Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD) Active, not recruiting NCT02028884 Phase 3 Satralizumab;Placebo;Baseline Treatment
12 A Double-masked, Placebo-controlled Study With Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects With Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders Active, not recruiting NCT02200770 Phase 2, Phase 3
13 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Satralizumab (SA237) as Monotherapy in Patients With Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Active, not recruiting NCT02073279 Phase 3 Satralizumab;Placebo
14 A Phase 2/3 Open-Label, Single-Arm Trial to Evaluate the Safety and Activity of Eculizumab in Pediatric Patients With Relapsing Neuromyelitis Optica Spectrum Disorder Not yet recruiting NCT04155424 Phase 2, Phase 3 Eculizumab
15 A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO) Terminated NCT01892345 Phase 3 Eculizumab;Placebo
16 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin (IVIg) Versus Standard Therapy for the Treatment of Transverse Myelitis in Adults and Children Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
17 Autologous Hematopoietic Stem Cell Transplant for Neuromyelitis Optica Spectrum Disorder (NMOSD) Withdrawn NCT03829566 Phase 2, Phase 3 Rituximab;Cyclophosphamide;Mesna;rATG;Methylprednisolone;G-CSF
18 Phase I/II Study of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Progressive Multiple Sclerosis and Neuromyelitis Optica Unknown status NCT01364246 Phase 1, Phase 2
19 Autologous Mesenchymal Stem Cells for the Treatment of Progressive and Refractory Neuromyelitis Optica Spectrum Disorders: an Open-label Phase 2a Proof-of-concept Study Completed NCT02249676 Phase 2
20 An Open Label Study of the Effects of Eculizumab in Neuromyelitis Optica Completed NCT00904826 Phase 1, Phase 2 Eculizumab
21 NPB-01(Intravenous Immunoglobulin) Therapy for Patients With Anti-aquaporin 4 Antibody Positive Neuromyelitis Optica Spectrum Disorder Not Provided Adequate Effect of Therapy to Steroids Plus Therapy. Completed NCT01845584 Phase 2 NPB-01
22 An Open Label, add-on Trial of Cetirizine for Patients With Neuromyelitis Optica Completed NCT02865018 Phase 1, Phase 2 cetirizine
23 Single-center, Open Label Trial of Bortezomib as add-on Treatment in Relapsing Neuromyelitis Optica Spectrum Disorder Completed NCT02893111 Phase 2 Bortezomib
24 Single-center, Open Label Trial of ACTEMRA® (Tocilizumab) as Monotherapy in Highly Active Neuromyelitis Optica Spectrum Disorders (NMOSD) Completed NCT03062579 Phase 1, Phase 2 Tocilizumab
25 Double-Blind, Placebo-Controlled Crossover Trial on the Safety and Efficacy of Sustained-Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
26 Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response After Out-of-Hospital Cardiac Arrest - a Randomized Clinical Trial Recruiting NCT03863015 Phase 2 Tocilizumab 20 Mg/mL Intravenous Solution;isotonic saline
27 Trial of High Dose Immunosuppressive Therapy With Hematopoietic Stem Cell Support in Devic's Disease Active, not recruiting NCT00787722 Phase 1, Phase 2 Cyclophosphamide;G-CSF;rATG;Mesna;Rituximab;Methylprednisolone
28 Non-myeloablative Autologous Hematopoietic Stem Cell Transplantation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy: A Phase II Trial Active, not recruiting NCT00278629 Phase 2
29 THOR - Tübingen Choroideremia Gene Therapy Trial Open Label Phase 2 Clinical Trial Using an Adeno-associated Viral Vector (AAV2) Encoding Rab-escort Protein 1 (REP1) Active, not recruiting NCT02671539 Phase 2
30 Comparison of the Efficacy and Safety of Immunoadsorption and Plasma Exchange for Acute Attack of Refractory Neuromyelitis Optica Spectrum Disorders: a Prospective, Multicenter, Single-blind, Randomized Controlled Clinical Trial Not yet recruiting NCT04064944 Phase 2
31 Autologous Hematopoietic Stem Cell Transplant in Patients With Neuromyelitis Optica Terminated NCT01339455 Phase 1, Phase 2
32 Phase 1b Study of C1-esterase Inhibitor (Cinryze) With Standard of Care for Acute Treatment of Neuromyelitis Optica Exacerbations Completed NCT01759602 Phase 1 C1-esterase inhibitor (Cinryze)
33 An Open-label Phase 1b Study of Avastin® (Bevacizumab) for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD). Completed NCT01777412 Phase 1 Bevacizumab
34 Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Completed NCT02276963 Phase 1 Ublituximab
35 A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
36 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab
37 Treatment of Multiple Sclerosis and Neuromyelitis Optica With Regulatory Dendritic Cell: Clinical Trial Phase 1 B Recruiting NCT02283671 Phase 1
38 A Phase I Clinical Trial of BAT4406F Injection on the Safety, Tolerability, and Pharmacokinetics in Patients With Neuromyelitis Optica Spectrum Disorders Not yet recruiting NCT04146285 Phase 1 BAT4406F
39 A Single Center Open Label Pilot Study of Alpha1-Antitrypsin: A Novel Treatment to Mitigate Neuromyelitis Optica Attacks Withdrawn NCT02087813 Phase 1 Alpha1-antitrypsin;methylprednisolone
40 Clinical Study of CD19/CD20 tanCAR T Cells in Relapsed and/or Refractory AQP4-IgG Seropositive Neuromyelitis Optica Spectrum Disorders (NMOSD) Withdrawn NCT03605238 Phase 1
41 The French Multiple Sclerosis Registry Unknown status NCT02889965
42 Evaluation of Macular and Retinal Nerve Fiber Layer Thickness Measurements for Detection of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Optical Coherence Tomography. Unknown status NCT01024985
43 The Correlation Between AQP-4 Ab and the Visual Function of Patients With Demyelinating ON at Onset Unknown status NCT02886377
44 Observational Prospective Multicentered Study Evaluating Initial Clinical Presentation of Inflammatory Optic Neuritis (ON) Associated or Not With Autoantibodies Anti- Myelin-oligodendrocyte-glycoprotein (MOG-Ab) Unknown status NCT03345537
45 Optical Coherence Tomography for the Etiological Diagnosis of Inflammatory Optic Neuritis Completed NCT02573792
46 A Prospective, Observational Study On The Progression Of Clinically Isolated Syndrome (CIS) To Multiple Sclerosis Over A 2-year Period Completed NCT01112657
47 Immunologic Biomarker Profile of Cerebrospinal Fluid Completed NCT04202055
48 Phase II, Randomized, Single Blind Sham Controlled Trial Investigating Scrambler Therapy for Neuropathic Pain Caused by Neuromyelitis Optica Spectrum Disorder Completed NCT03452176
49 A Pathologic-MRI Reappraisal of Patients With Atypical Idiopathic Inflammatory Demyelinating Disorders Completed NCT03121105
50 A Non-randomized, Exploratory, Study to Assess Clinical Response to Gilenya® (Fingolimod) in a Cohort of Relapsing Remitting Hispanic MS Forms Completed NCT01592097

Search NIH Clinical Center for Neuromyelitis Optica

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neuromyelitis Optica cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: neuromyelitis optica

Genetic Tests for Neuromyelitis Optica

Anatomical Context for Neuromyelitis Optica

MalaCards organs/tissues related to Neuromyelitis Optica:

40
Brain, Spinal Cord, B Cells, Eye, T Cells, Bone, Lung
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neuromyelitis Optica:
# Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Neuromyelitis Optica

Articles related to Neuromyelitis Optica:

(show top 50) (show all 3609)
# Title Authors PMID Year
1
Neuromyelitis optica: current concepts and prospects for future management. 61 52
19696670 2009
2
Marked hypotonia in an infant of a mother with Devic disease. 54 61
20028941 2010
3
Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica. 54 61
20463974 2010
4
Immunoglobulin M antibodies to aquaporin-4 in neuromyelitis optica and related disorders. 54 61
20184532 2010
5
Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity. 54 61
20227773 2010
6
Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status. 54 61
20122699 2010
7
Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. 54 61
20117794 2010
8
Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. 54 61
20047900 2010
9
Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: implication in orthogonal array formation and neuromyelitis optica antibody interaction. 54 61
20007705 2010
10
Syringomyelia in neuromyelitis optica seropositive for aquaporin-4 antibody. 54 61
20154446 2010
11
[Construction and clinical application of lentivirus-AQP4 expressing vector]. 54 61
20356560 2010
12
Enhanced IL-6 production in aquaporin-4 antibody positive neuromyelitis optica patients. 54 61
20128675 2010
13
Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. 54 61
19965522 2009
14
Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells. 54 61
19843522 2009
15
Western blot analysis for the detection of serum antibodies recognizing linear Aquaporin-4 epitopes in patients with Neuromyelitis Optica. 54 61
19850359 2009
16
Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica. 54 61
19389490 2009
17
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. 54 61
19917985 2009
18
Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. 54 61
19938104 2009
19
[Regulation, structure and function of brain aquaporin]. 54 61
20030210 2009
20
[Experimental models of neuromyelitis optica]. 54 61
20030243 2009
21
Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study. 54 61
19695715 2009
22
Antiacquaporin 4 antibodies detection by different techniques in neuromyelitis optica patients. 54 61
19667009 2009
23
Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies. 54 61
19229993 2009
24
Extensive vasogenic edema of anti-aquaporin-4 antibody-related brain lesions. 54 61
19625334 2009
25
"Cloud-like enhancement" is a magnetic resonance imaging abnormality specific to neuromyelitis optica. 54 61
19798642 2009
26
Aquaporins: translating bench research to human disease. 54 61
19448080 2009
27
Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. 54 61
19448094 2009
28
Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker. 54 61
19372295 2009
29
Neuromyelitis optica with HTLV-1 infection: different from acute progressive HAM? 54 61
19571450 2009
30
Autoantibodies in inflammatory demyelinating diseases of the central nervous system. 54 61
18951202 2008
31
Disseminated encephalomyelitis in adults. 54 61
18703274 2008
32
Antibody to aquaporin-4 in the long-term course of neuromyelitis optica. 54 61
18945724 2008
33
Neuromyelitis optica in patients with gluten sensitivity associated with antibodies to aquaporin-4. 54 61
18708571 2008
34
CNS aquaporin-4 autoimmunity in children. 54 61
18509092 2008
35
Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. 54 61
18625857 2008
36
Neuromyelitis optica (NMO) antibody positivity in patients with transverse myelitis and no visual manifestations. 54 61
18432545 2008
37
Neuromyelitis optica pathogenesis and aquaporin 4. 54 61
18510734 2008
38
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. 54 61
18509235 2008
39
Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. 54 61
18462810 2008
40
Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica. 54 61
18334978 2008
41
Water movements in the brain: role of aquaporins. 54 61
18054802 2008
42
Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. 54 61
17702782 2007
43
The spectrum of neuromyelitis optica. 54 61
17706564 2007
44
Neuromyelitis optica. 54 61
17495617 2007
45
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. 54 61
17405762 2007
46
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre. 54 61
17449477 2007
47
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. 54 61
17282996 2007
48
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. 54 61
17439296 2007
49
Absence of aquaporin-4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter. 54 61
17143632 2007
50
Loss of aquaporin-4 in active perivascular lesions in neuromyelitis optica: a case report. 54 61
16778375 2006

Variations for Neuromyelitis Optica

Expression for Neuromyelitis Optica

Search GEO for disease gene expression data for Neuromyelitis Optica.

Pathways for Neuromyelitis Optica

Pathways related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TNFSF13B S100B IL6 IL4 IL17A HLA-DRB1
2
Show member pathways
13.26 TNFSF13B IL6 IL4 IL17A CXCL13 CXCL10
3
Show member pathways
13.17 TNFSF13B IL6 IL4 IL17A HLA-DRB1 HLA-DPB1
4
Show member pathways
13.1 TNFSF13B IL6 IL4 IL17A CXCL13 CXCL10
5
Show member pathways
12.5 TNFSF13B IL6 IL4 IL17A HLA-DRB1 HLA-DPB1
6
Show member pathways
12.46 IL6 IL4 IL17A HLA-DRB1 HLA-DPB1
7 12.41 TNFSF13B IL4 IL17A CXCL10 CD40LG
8
Show member pathways
12.2 IL6 IL4 IL17A CXCL10
9
Show member pathways
12.14 IL4 HLA-DRB1 HLA-DPB1 CD40LG
10 11.76 IL6 IL4 HLA-DRB1 HLA-DPB1 CD59
11 11.69 TNFSF13B IL6 IL17A HLA-DRB1 HLA-DPB1
12 11.65 S100B MOG GFAP
13 11.45 FCRL3 CD40LG CD27
14 11.4 IL6 IL4 CXCL10
15 11.3 TNFSF13B MBP IL6 IL4 GFAP CXCL10
16 11.2 IL6 IL4 IL17A CXCL13 CXCL10
17 11.16 IL6 IL4 IL17A
18 11.1 IL6 IL4 HLA-DRB1
19 10.76 TNFSF13B IL6 IL4 IL17A GFAP CXCL13

GO Terms for Neuromyelitis Optica

Cellular components related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.22 TNFSF13B SLC1A2 MOG MBP HLA-DRB1 HLA-DPB1
2 extracellular space GO:0005615 9.97 TNFSF13B S100B IL6 IL4 IL17A CXCL13
3 extracellular region GO:0005576 9.9 TNFSF13B S100B IL6 IL4 IL17A CXCL13
4 cell surface GO:0009986 9.56 SLC1A2 MBP HLA-DRB1 HLA-DPB1 FCRL3 CD59
5 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-DRB1 HLA-DPB1 CD59
6 astrocyte end-foot GO:0097450 9.26 GFAP AQP4
7 external side of plasma membrane GO:0009897 9.17 MOG IL17A HLA-DRB1 CXCL10 CD40LG CD27

Biological processes related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 IL6 IL4 CD40LG CD27 AQP1
2 cell surface receptor signaling pathway GO:0007166 9.8 CXCL13 CXCL10 CD59 CD27
3 inflammatory response GO:0006954 9.8 IL6 IL17A CXCL13 CXCL10 CD40LG
4 regulation of immune response GO:0050776 9.78 TNFSF13B MOG IL4 CD40LG
5 multicellular organismal water homeostasis GO:0050891 9.46 AQP4 AQP1
6 pancreatic juice secretion GO:0030157 9.43 AQP5 AQP1
7 positive regulation of B cell proliferation GO:0030890 9.43 TNFSF13B IL4 FCRL3
8 immunoglobulin secretion GO:0048305 9.37 TNFSF13B CD40LG
9 positive regulation of T cell proliferation GO:0042102 9.35 TNFSF13B IL6 IL4 HLA-DPB1 CD40LG
10 water transport GO:0006833 9.33 AQP5 AQP4 AQP1
11 carbon dioxide transport GO:0015670 9.32 AQP5 AQP1
12 immune response GO:0006955 9.32 TNFSF13B MBP IL6 IL4 IL17A HLA-DRB1

Molecular functions related to Neuromyelitis Optica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.33 AQP5 AQP4 AQP1
2 CXCR3 chemokine receptor binding GO:0048248 9.26 CXCL13 CXCL10
3 cytokine activity GO:0005125 9.17 TNFSF13B IL6 IL4 IL17A CXCL13 CXCL10
4 water channel activity GO:0015250 9.13 AQP5 AQP4 AQP1

Sources for Neuromyelitis Optica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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